PRDX2P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of attachment of spindle microtubules to kinetochore (GO:0051988)6.71937728
2negative regulation of cytosolic calcium ion concentration (GO:0051481)5.79013779
3piRNA metabolic process (GO:0034587)5.04218756
4cellular ketone body metabolic process (GO:0046950)4.83884854
5regulation of acrosome reaction (GO:0060046)4.56080610
6regulation of translational termination (GO:0006449)4.52359935
7ether lipid metabolic process (GO:0046485)4.49455076
8opioid receptor signaling pathway (GO:0038003)4.44461422
9cullin deneddylation (GO:0010388)4.42315566
10branched-chain amino acid catabolic process (GO:0009083)4.32417629
11negative regulation of neurological system process (GO:0031645)4.30999019
12adult feeding behavior (GO:0008343)4.30129241
13ketone body metabolic process (GO:1902224)4.25162380
14behavioral response to ethanol (GO:0048149)4.18128640
15RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)4.14235636
16heparin biosynthetic process (GO:0030210)4.02062909
17heparin metabolic process (GO:0030202)4.02062909
18rRNA modification (GO:0000154)4.00854663
19rRNA methylation (GO:0031167)3.97389004
20mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.95472470
21proteasome assembly (GO:0043248)3.94698631
22ATP synthesis coupled proton transport (GO:0015986)3.94341033
23energy coupled proton transport, down electrochemical gradient (GO:0015985)3.94341033
24DNA deamination (GO:0045006)3.90467477
25establishment of protein localization to mitochondrial membrane (GO:0090151)3.87165390
26negative regulation of cAMP-mediated signaling (GO:0043951)3.85077558
27tyrosine phosphorylation of STAT protein (GO:0007260)3.82279127
28protein deneddylation (GO:0000338)3.76224890
29adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.70467686
30DNA double-strand break processing (GO:0000729)3.62975868
31behavioral response to nicotine (GO:0035095)3.61244012
32respiratory chain complex IV assembly (GO:0008535)3.60551097
33ncRNA catabolic process (GO:0034661)3.55025674
34dopamine transport (GO:0015872)3.54350331
35pseudouridine synthesis (GO:0001522)3.49738825
36phospholipid homeostasis (GO:0055091)3.46893668
37phosphatidylserine acyl-chain remodeling (GO:0036150)3.45896573
38branched-chain amino acid metabolic process (GO:0009081)3.42352843
39cytochrome complex assembly (GO:0017004)3.38984503
40positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.33294373
41nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.33214606
42regulation of protein glycosylation (GO:0060049)3.23888154
43spindle assembly involved in mitosis (GO:0090307)3.23466821
44negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.22085083
45indolalkylamine metabolic process (GO:0006586)3.21260895
46signal peptide processing (GO:0006465)3.18614977
47retinal cone cell development (GO:0046549)3.17806664
48regulation of centrosome cycle (GO:0046605)3.15235568
49sphingoid metabolic process (GO:0046519)3.12733714
50regulation of glucokinase activity (GO:0033131)3.12631575
51regulation of hexokinase activity (GO:1903299)3.12631575
52glycerophospholipid catabolic process (GO:0046475)3.11946391
53positive regulation of cAMP-mediated signaling (GO:0043950)3.09609101
54N-terminal protein amino acid acetylation (GO:0006474)3.08151639
55keratinocyte development (GO:0003334)3.03339062
56negative regulation of thymocyte apoptotic process (GO:0070244)3.00355208
57preassembly of GPI anchor in ER membrane (GO:0016254)3.00106369
58positive regulation of Rho protein signal transduction (GO:0035025)2.99649887
59DNA damage response, detection of DNA damage (GO:0042769)2.99440337
60regulation of cellular amino acid metabolic process (GO:0006521)2.97623644
61negative regulation of DNA-dependent DNA replication (GO:2000104)2.96884422
62response to pheromone (GO:0019236)2.95323894
63protein complex biogenesis (GO:0070271)2.92625041
64sphingosine metabolic process (GO:0006670)2.90601374
65regulation of bile acid biosynthetic process (GO:0070857)2.89748897
66mRNA cleavage (GO:0006379)2.88409556
67regulation of female gonad development (GO:2000194)2.88039214
68ovulation cycle (GO:0042698)2.88036057
69mitochondrial respiratory chain complex assembly (GO:0033108)2.87816519
70valine metabolic process (GO:0006573)2.86173914
71regulation of transmission of nerve impulse (GO:0051969)2.86157020
72diol metabolic process (GO:0034311)2.85174559
73exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.83344923
74detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.82975749
75water-soluble vitamin biosynthetic process (GO:0042364)2.81812834
76negative regulation of interleukin-1 beta production (GO:0032691)2.80163140
77mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.79858854
78positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.79704530
79glycerol ether metabolic process (GO:0006662)2.79318161
80DNA replication-dependent nucleosome organization (GO:0034723)2.79164202
81DNA replication-dependent nucleosome assembly (GO:0006335)2.79164202
82regulation of nuclear cell cycle DNA replication (GO:0033262)2.77140592
83replication fork processing (GO:0031297)2.76942327
84lactate metabolic process (GO:0006089)2.74133563
85tryptophan metabolic process (GO:0006568)2.71900856
86otic vesicle formation (GO:0030916)2.70919888
87termination of RNA polymerase III transcription (GO:0006386)2.67757631
88transcription elongation from RNA polymerase III promoter (GO:0006385)2.67757631
89DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.64796156
90positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.64613629
91positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.64613629
92positive regulation of mitotic sister chromatid separation (GO:1901970)2.64613629
93DNA catabolic process, exonucleolytic (GO:0000738)2.63760524
94signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.63015828
95signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.63015828
96signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.63015828
97regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.62681140
98mitotic sister chromatid segregation (GO:0000070)2.62283023
99negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.61289518
100protein neddylation (GO:0045116)2.60865340

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human4.22761159
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.54923145
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.42358428
4ZNF274_21170338_ChIP-Seq_K562_Hela3.26489865
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.24444410
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.89677010
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.78426087
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.54635075
9TAF15_26573619_Chip-Seq_HEK293_Human2.52529420
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.47159034
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.25351056
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.04697025
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01490179
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99785493
15NOTCH1_21737748_ChIP-Seq_TLL_Human1.96822367
16IGF1R_20145208_ChIP-Seq_DFB_Human1.93827488
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88332701
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87717278
19FOXM1_23109430_ChIP-Seq_U2OS_Human1.87086410
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.83386304
21FUS_26573619_Chip-Seq_HEK293_Human1.83330961
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.80199604
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.78932650
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.75264688
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.74577538
26VDR_23849224_ChIP-Seq_CD4+_Human1.72380818
27NANOG_19829295_ChIP-Seq_ESCs_Human1.69803566
28SOX2_19829295_ChIP-Seq_ESCs_Human1.69803566
29EWS_26573619_Chip-Seq_HEK293_Human1.69193826
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.63149090
31TP53_22573176_ChIP-Seq_HFKS_Human1.62975946
32P300_19829295_ChIP-Seq_ESCs_Human1.60376695
33NFE2_27457419_Chip-Seq_LIVER_Mouse1.56183407
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51192789
35ER_23166858_ChIP-Seq_MCF-7_Human1.50152936
36PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47467942
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47201018
38EZH2_27294783_Chip-Seq_NPCs_Mouse1.47115700
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46972164
40CBP_20019798_ChIP-Seq_JUKART_Human1.46972164
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46725506
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44488088
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44488088
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.42729610
45GBX2_23144817_ChIP-Seq_PC3_Human1.41735644
46ELK1_19687146_ChIP-ChIP_HELA_Human1.40922017
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40589309
48FOXP3_21729870_ChIP-Seq_TREG_Human1.39816891
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37428378
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.35830900
51TCF4_23295773_ChIP-Seq_U87_Human1.34470006
52FOXA1_21572438_ChIP-Seq_LNCaP_Human1.33362114
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.32077281
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30641868
55CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30547007
56CRX_20693478_ChIP-Seq_RETINA_Mouse1.27682611
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26066244
58AR_21572438_ChIP-Seq_LNCaP_Human1.24705545
59TCF4_22108803_ChIP-Seq_LS180_Human1.22753052
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22013887
61BCAT_22108803_ChIP-Seq_LS180_Human1.21579677
62AR_25329375_ChIP-Seq_VCAP_Human1.21197233
63KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21083131
64RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19285840
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18711964
66CDX2_22108803_ChIP-Seq_LS180_Human1.14725068
67HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12747301
68HOXB7_26014856_ChIP-Seq_BT474_Human1.12038507
69NCOR_22424771_ChIP-Seq_293T_Human1.11943836
70GATA3_21878914_ChIP-Seq_MCF-7_Human1.11933475
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09083884
72HTT_18923047_ChIP-ChIP_STHdh_Human1.08697266
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08696482
74P300_18555785_Chip-Seq_ESCs_Mouse1.07986438
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.07777968
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07777968
77FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07657778
78SMAD4_21799915_ChIP-Seq_A2780_Human1.07178825
79AUTS2_25519132_ChIP-Seq_293T-REX_Human1.07150229
80SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07099698
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05911448
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.03945745
83STAT3_18555785_Chip-Seq_ESCs_Mouse1.02773069
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00994331
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.00649834
86OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99984958
87STAT3_23295773_ChIP-Seq_U87_Human0.99697009
88LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99126420
89CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98352370
90SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98308147
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97382935
92CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96645373
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.96299480
94DCP1A_22483619_ChIP-Seq_HELA_Human0.95944831
95EGR1_23403033_ChIP-Seq_LIVER_Mouse0.95943577
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95792087
97TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95669365
98GABP_19822575_ChIP-Seq_HepG2_Human0.95130045
99P53_22387025_ChIP-Seq_ESCs_Mouse0.94190241
100CREB1_15753290_ChIP-ChIP_HEK293T_Human0.93890288

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001968_abnormal_touch/_nociception4.00389646
2MP0009046_muscle_twitch3.41967913
3MP0005645_abnormal_hypothalamus_physiol3.40369089
4MP0002876_abnormal_thyroid_physiology3.24390248
5MP0006035_abnormal_mitochondrial_morpho3.23867301
6MP0008877_abnormal_DNA_methylation3.08678353
7MP0005646_abnormal_pituitary_gland3.01885963
8MP0003195_calcinosis2.70607722
9MP0009780_abnormal_chondrocyte_physiolo2.68336651
10MP0002254_reproductive_system_inflammat2.43085116
11MP0008872_abnormal_physiological_respon2.29116641
12MP0003880_abnormal_central_pattern2.28622159
13MP0003315_abnormal_perineum_morphology2.23708185
14MP0004147_increased_porphyrin_level2.22287347
15MP0001348_abnormal_lacrimal_gland2.19542407
16MP0002272_abnormal_nervous_system2.13143957
17MP0006036_abnormal_mitochondrial_physio2.11398500
18MP0005084_abnormal_gallbladder_morpholo2.00444768
19MP0006292_abnormal_olfactory_placode1.99907641
20MP0010386_abnormal_urinary_bladder1.95884489
21MP0005551_abnormal_eye_electrophysiolog1.88841779
22MP0003718_maternal_effect1.81583780
23MP0001984_abnormal_olfaction1.79004452
24MP0009745_abnormal_behavioral_response1.71149597
25MP0002736_abnormal_nociception_after1.70626994
26MP0005167_abnormal_blood-brain_barrier1.65673314
27MP0004215_abnormal_myocardial_fiber1.53935107
28MP0000013_abnormal_adipose_tissue1.53422675
29MP0005187_abnormal_penis_morphology1.49650361
30MP0002638_abnormal_pupillary_reflex1.47119693
31MP0003567_abnormal_fetal_cardiomyocyte1.44569673
32MP0004742_abnormal_vestibular_system1.43355588
33MP0002277_abnormal_respiratory_mucosa1.41754085
34MP0009697_abnormal_copulation1.40500322
35MP0009840_abnormal_foam_cell1.39979506
36MP0005083_abnormal_biliary_tract1.39851016
37MP0008875_abnormal_xenobiotic_pharmacok1.39681838
38MP0005253_abnormal_eye_physiology1.34399188
39MP0000427_abnormal_hair_cycle1.32222467
40MP0003191_abnormal_cellular_cholesterol1.30825911
41MP0003011_delayed_dark_adaptation1.27735089
42MP0006276_abnormal_autonomic_nervous1.27361882
43MP0008058_abnormal_DNA_repair1.26615957
44MP0002102_abnormal_ear_morphology1.26152373
45MP0002733_abnormal_thermal_nociception1.25630685
46MP0005379_endocrine/exocrine_gland_phen1.24689115
47MP0002067_abnormal_sensory_capabilities1.17081364
48MP0001970_abnormal_pain_threshold1.16853062
49MP0001486_abnormal_startle_reflex1.16268638
50MP0010234_abnormal_vibrissa_follicle1.14620210
51MP0006072_abnormal_retinal_apoptosis1.14397807
52MP0004145_abnormal_muscle_electrophysio1.12549070
53MP0004957_abnormal_blastocyst_morpholog1.11643056
54MP0003786_premature_aging1.09189860
55MP0010094_abnormal_chromosome_stability1.08771843
56MP0002837_dystrophic_cardiac_calcinosis1.07952049
57MP0003633_abnormal_nervous_system1.06439171
58MP0003868_abnormal_feces_composition1.06430660
59MP0005360_urolithiasis1.05984747
60MP0001664_abnormal_digestion1.05327318
61MP0001986_abnormal_taste_sensitivity1.02327873
62MP0003693_abnormal_embryo_hatching1.00885115
63MP0004085_abnormal_heartbeat0.99336697
64MP0001501_abnormal_sleep_pattern0.98812735
65MP0003638_abnormal_response/metabolism_0.97746877
66MP0000358_abnormal_cell_content/0.95431905
67MP0002229_neurodegeneration0.94060953
68MP0002064_seizures0.92742486
69MP0003635_abnormal_synaptic_transmissio0.89958916
70MP0001919_abnormal_reproductive_system0.88820768
71MP0005310_abnormal_salivary_gland0.86768895
72MP0003787_abnormal_imprinting0.86305496
73MP0000230_abnormal_systemic_arterial0.84931792
74MP0005332_abnormal_amino_acid0.84453050
75MP0002160_abnormal_reproductive_system0.80024542
76MP0000613_abnormal_salivary_gland0.79089955
77MP0009764_decreased_sensitivity_to0.78090313
78MP0003186_abnormal_redox_activity0.77734428
79MP0000538_abnormal_urinary_bladder0.77076683
80MP0005636_abnormal_mineral_homeostasis0.73825273
81MP0004036_abnormal_muscle_relaxation0.73249119
82MP0005410_abnormal_fertilization0.70662381
83MP0001944_abnormal_pancreas_morphology0.70432660
84MP0001929_abnormal_gametogenesis0.67707632
85MP0001440_abnormal_grooming_behavior0.67622080
86MP0009333_abnormal_splenocyte_physiolog0.66762866
87MP0002572_abnormal_emotion/affect_behav0.66174795
88MP0004043_abnormal_pH_regulation0.65928827
89MP0002557_abnormal_social/conspecific_i0.65200249
90MP0008775_abnormal_heart_ventricle0.65180984
91MP0004782_abnormal_surfactant_physiolog0.65128680
92MP0002751_abnormal_autonomic_nervous0.65023358
93MP0005389_reproductive_system_phenotype0.64780046
94MP0001485_abnormal_pinna_reflex0.63803014
95MP0002938_white_spotting0.63267103
96MP0003941_abnormal_skin_development0.60673961
97MP0002210_abnormal_sex_determination0.60647208
98MP0002735_abnormal_chemical_nociception0.59424135
99MP0001529_abnormal_vocalization0.58910627
100MP0001905_abnormal_dopamine_level0.58431302

Predicted human phenotypes

RankGene SetZ-score
1Thyroid-stimulating hormone excess (HP:0002925)5.64144487
23-Methylglutaconic aciduria (HP:0003535)4.34916074
3Progressive inability to walk (HP:0002505)3.96830871
4Pancreatic islet-cell hyperplasia (HP:0004510)3.44245217
5Abnormality of the pancreatic islet cells (HP:0006476)3.38863981
6Abnormality of endocrine pancreas physiology (HP:0012093)3.38863981
7Chronic hepatic failure (HP:0100626)3.38699716
8Intestinal atresia (HP:0011100)3.32242406
9Methylmalonic acidemia (HP:0002912)3.26179660
10Focal motor seizures (HP:0011153)3.13216110
11Increased CSF lactate (HP:0002490)3.12507478
12Acute necrotizing encephalopathy (HP:0006965)3.10884243
13Hypothermia (HP:0002045)3.05083348
14Inability to walk (HP:0002540)3.02654053
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.95670787
16Epileptic encephalopathy (HP:0200134)2.95075297
17Methylmalonic aciduria (HP:0012120)2.92951634
18Volvulus (HP:0002580)2.92945304
19Progressive macrocephaly (HP:0004481)2.89288954
20Broad alveolar ridges (HP:0000187)2.85050015
21Abnormality of the labia minora (HP:0012880)2.80043355
22Mesangial abnormality (HP:0001966)2.79455626
23Increased serum pyruvate (HP:0003542)2.77423786
24Large eyes (HP:0001090)2.72326108
25Acute encephalopathy (HP:0006846)2.71031113
26Agitation (HP:0000713)2.70930614
27Mitochondrial inheritance (HP:0001427)2.70797484
28Large for gestational age (HP:0001520)2.69157293
29Abnormal mitochondria in muscle tissue (HP:0008316)2.60614186
30Abnormality of dicarboxylic acid metabolism (HP:0010995)2.59223087
31Dicarboxylic aciduria (HP:0003215)2.59223087
32Sensory axonal neuropathy (HP:0003390)2.59039535
33Prominent metopic ridge (HP:0005487)2.58659801
34Abnormality of glycolysis (HP:0004366)2.57699284
35Abnormality of lateral ventricle (HP:0030047)2.56492440
36Gaze-evoked nystagmus (HP:0000640)2.56244454
37Atonic seizures (HP:0010819)2.50863802
38Abnormality of vitamin B metabolism (HP:0004340)2.48317539
39Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.47956908
40Abnormality of methionine metabolism (HP:0010901)2.47110334
41Tubular atrophy (HP:0000092)2.39921655
42Broad-based gait (HP:0002136)2.36062680
43Abnormality of the vitamin B12 metabolism (HP:0004341)2.33247265
44Abnormal pancreas size (HP:0012094)2.31746294
45Abnormality of the renal cortex (HP:0011035)2.30396249
46Increased serum lactate (HP:0002151)2.29993149
47Poor head control (HP:0002421)2.27951223
48Asplenia (HP:0001746)2.25104497
49Hypomagnesemia (HP:0002917)2.22912231
50Aplastic anemia (HP:0001915)2.21138649
51Aplasia/Hypoplasia of the spleen (HP:0010451)2.20001042
52Pendular nystagmus (HP:0012043)2.19574721
53Optic nerve hypoplasia (HP:0000609)2.19303282
54Dialeptic seizures (HP:0011146)2.19098252
55Hypoproteinemia (HP:0003075)2.17083098
56Hypoplasia of the uterus (HP:0000013)2.16513923
57Abnormality of aspartate family amino acid metabolism (HP:0010899)2.14121227
58Poor speech (HP:0002465)2.12245062
59Abnormality of midbrain morphology (HP:0002418)2.12096648
60Molar tooth sign on MRI (HP:0002419)2.12096648
61Abnormality of the ileum (HP:0001549)2.08049570
62Limb dystonia (HP:0002451)2.07218204
63Febrile seizures (HP:0002373)2.06793078
64Abnormality of the metopic suture (HP:0005556)2.06696393
65Abnormality of homocysteine metabolism (HP:0010919)2.06634669
66Homocystinuria (HP:0002156)2.06634669
67Hyperglycinuria (HP:0003108)2.03919651
68Ketoacidosis (HP:0001993)2.03609268
69Hepatic necrosis (HP:0002605)2.02926768
70Renal cortical cysts (HP:0000803)2.02650973
71Polydipsia (HP:0001959)2.01432497
72Abnormal drinking behavior (HP:0030082)2.01432497
73Status epilepticus (HP:0002133)2.00800138
74Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.00697079
75Degeneration of anterior horn cells (HP:0002398)2.00520195
76Abnormality of the anterior horn cell (HP:0006802)2.00520195
77Pancreatic cysts (HP:0001737)1.99938640
78Abnormality of macular pigmentation (HP:0008002)1.97657525
79Symptomatic seizures (HP:0011145)1.93899682
80Hepatocellular necrosis (HP:0001404)1.93807834
81Absence seizures (HP:0002121)1.93525446
82Increased hepatocellular lipid droplets (HP:0006565)1.92730100
83Aplasia/hypoplasia of the uterus (HP:0008684)1.91698472
84Cerebral edema (HP:0002181)1.90300734
85Metabolic alkalosis (HP:0200114)1.90208609
86Pancreatic fibrosis (HP:0100732)1.90082698
87Abnormality of the aortic arch (HP:0012303)1.89381528
88Progressive external ophthalmoplegia (HP:0000590)1.88543595
89Progressive muscle weakness (HP:0003323)1.88392555
90Congenital ichthyosiform erythroderma (HP:0007431)1.87487388
91Congenital stationary night blindness (HP:0007642)1.87127216
92Lipid accumulation in hepatocytes (HP:0006561)1.86879466
93Optic disc pallor (HP:0000543)1.85640964
94Decreased electroretinogram (ERG) amplitude (HP:0000654)1.85425546
95Amblyopia (HP:0000646)1.85144281
96Carpal bone hypoplasia (HP:0001498)1.82842166
97Abnormality of the pons (HP:0007361)1.77680965
98Fatigue (HP:0012378)1.77456523
99Hypoplasia of the pons (HP:0012110)1.77048693
100Polyuria (HP:0000103)1.75377013

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.72854449
2FRK4.56688032
3ADRBK24.39411575
4EIF2AK34.22235111
5MAP4K23.47916508
6TSSK63.40397037
7DYRK33.15579968
8MAP3K122.92002984
9BUB12.68235085
10CLK12.41824866
11NEK22.41109779
12ZAK2.17136857
13NEK11.97162307
14PINK11.91626831
15STK31.79517672
16VRK21.73606584
17PLK31.63399787
18STK161.59189018
19NUAK11.52306584
20PBK1.41961676
21TTK1.37445529
22STK391.32089505
23PLK21.26746001
24GRK11.26378854
25EIF2AK11.20430292
26TLK11.19354291
27OXSR11.18688455
28PRKCG1.16039648
29PDK21.12791949
30CASK1.10445545
31WNK30.99882616
32IRAK10.99661443
33ADRBK10.97265323
34WNK40.96834360
35GRK50.93523000
36FGFR20.92826823
37TRIM280.91286161
38TNIK0.90446718
39MAP3K20.90051215
40PTK60.86858299
41PRKCE0.83831539
42STK100.83508685
43CSNK1G20.81445491
44VRK10.77857383
45EIF2AK20.76432123
46MAPKAPK50.75347272
47CSNK1G30.72377856
48STK38L0.70175423
49TAF10.69558474
50MAP2K60.69130526
51MYLK0.67911533
52RPS6KA40.67016833
53PNCK0.66662104
54NEK90.66648277
55PHKG20.66163440
56PHKG10.66163440
57PRKCI0.65060573
58MKNK20.64611452
59WEE10.60252916
60MAP3K90.60161147
61PAK30.57305069
62PLK10.56863191
63INSRR0.55434806
64TAOK10.55137690
65MKNK10.54690823
66ATR0.54531472
67CSNK1G10.54308571
68PLK40.54219264
69MAPK110.53478562
70BMPR1B0.52989959
71TXK0.52802354
72DMPK0.49003902
73PASK0.45041977
74MAP3K30.43632794
75MAP3K80.42718698
76MINK10.42052122
77AKT20.40786473
78CSNK1A1L0.40624689
79BCR0.39572602
80AURKB0.39114167
81SRPK10.38320704
82MAPK130.37694570
83CDK190.36934270
84LIMK10.35063117
85TGFBR10.34962404
86CAMK2A0.31895347
87CSNK1A10.30928571
88CCNB10.28532210
89ATM0.27140724
90PRKCA0.27094507
91PRKG10.24742299
92CSNK2A20.23736907
93PRKCB0.23082807
94RPS6KA50.22554466
95CSNK2A10.22027057
96ALK0.21350212
97CSNK1E0.19110780
98CHEK10.17972010
99TIE10.17318894
100MAPKAPK30.16877236

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.74895890
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.23905541
3Protein export_Homo sapiens_hsa030602.79124748
4Oxidative phosphorylation_Homo sapiens_hsa001902.51438582
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.50533795
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.34022790
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.32820800
8Propanoate metabolism_Homo sapiens_hsa006402.29128102
9Butanoate metabolism_Homo sapiens_hsa006502.21362790
10Parkinsons disease_Homo sapiens_hsa050122.20989725
11Olfactory transduction_Homo sapiens_hsa047402.17827798
12Basal transcription factors_Homo sapiens_hsa030222.16675517
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.96543919
14Homologous recombination_Homo sapiens_hsa034401.92514967
15Tryptophan metabolism_Homo sapiens_hsa003801.86600727
16Phototransduction_Homo sapiens_hsa047441.84200794
17RNA polymerase_Homo sapiens_hsa030201.73930352
18RNA degradation_Homo sapiens_hsa030181.65847649
19Non-homologous end-joining_Homo sapiens_hsa034501.61383380
20Huntingtons disease_Homo sapiens_hsa050161.60229731
21Nitrogen metabolism_Homo sapiens_hsa009101.59792493
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.56735812
23Fatty acid elongation_Homo sapiens_hsa000621.56594292
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.53583577
25Fatty acid degradation_Homo sapiens_hsa000711.52357828
26Alzheimers disease_Homo sapiens_hsa050101.49515306
27Fanconi anemia pathway_Homo sapiens_hsa034601.48971076
28beta-Alanine metabolism_Homo sapiens_hsa004101.43663191
29Morphine addiction_Homo sapiens_hsa050321.42369380
30Linoleic acid metabolism_Homo sapiens_hsa005911.41361637
31One carbon pool by folate_Homo sapiens_hsa006701.39562630
32Selenocompound metabolism_Homo sapiens_hsa004501.34785552
33Ether lipid metabolism_Homo sapiens_hsa005651.30593923
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.24059691
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.23212241
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22424861
37Long-term depression_Homo sapiens_hsa047301.20504799
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16128107
39Pyruvate metabolism_Homo sapiens_hsa006201.13203943
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10794604
41Regulation of autophagy_Homo sapiens_hsa041401.09367253
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.04395521
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03106981
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02549067
45Sulfur metabolism_Homo sapiens_hsa009201.02216126
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01434375
47Collecting duct acid secretion_Homo sapiens_hsa049660.99423674
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.92633482
49Nicotine addiction_Homo sapiens_hsa050330.89052535
50RNA transport_Homo sapiens_hsa030130.88530947
51Peroxisome_Homo sapiens_hsa041460.85415461
52Glutathione metabolism_Homo sapiens_hsa004800.82230902
53Fatty acid metabolism_Homo sapiens_hsa012120.80993592
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.79427003
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78471889
56Caffeine metabolism_Homo sapiens_hsa002320.77711024
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76513953
58Cardiac muscle contraction_Homo sapiens_hsa042600.76283180
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75449963
60Circadian entrainment_Homo sapiens_hsa047130.75375170
61Purine metabolism_Homo sapiens_hsa002300.73591539
62Mineral absorption_Homo sapiens_hsa049780.71599776
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70581854
64Glutamatergic synapse_Homo sapiens_hsa047240.70577554
65Mismatch repair_Homo sapiens_hsa034300.69663236
66Sphingolipid metabolism_Homo sapiens_hsa006000.69432661
67Metabolic pathways_Homo sapiens_hsa011000.68505317
68Fat digestion and absorption_Homo sapiens_hsa049750.68078502
69Serotonergic synapse_Homo sapiens_hsa047260.68077425
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67641959
71ABC transporters_Homo sapiens_hsa020100.65026766
72Insulin secretion_Homo sapiens_hsa049110.62871096
73Glycerolipid metabolism_Homo sapiens_hsa005610.60950440
74Dorso-ventral axis formation_Homo sapiens_hsa043200.59132786
75GABAergic synapse_Homo sapiens_hsa047270.58343195
76Circadian rhythm_Homo sapiens_hsa047100.57883706
77Retinol metabolism_Homo sapiens_hsa008300.56893161
78Pyrimidine metabolism_Homo sapiens_hsa002400.56261582
79Vitamin digestion and absorption_Homo sapiens_hsa049770.52307685
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.52030295
81Arachidonic acid metabolism_Homo sapiens_hsa005900.51059731
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50994762
83Taste transduction_Homo sapiens_hsa047420.49695937
84Salivary secretion_Homo sapiens_hsa049700.47236404
85Ovarian steroidogenesis_Homo sapiens_hsa049130.45344916
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44673723
87African trypanosomiasis_Homo sapiens_hsa051430.44345980
88Pancreatic secretion_Homo sapiens_hsa049720.44103558
89Dopaminergic synapse_Homo sapiens_hsa047280.43965007
90Nucleotide excision repair_Homo sapiens_hsa034200.43611534
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.41996217
92Arginine and proline metabolism_Homo sapiens_hsa003300.41405692
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38287210
94Calcium signaling pathway_Homo sapiens_hsa040200.38040677
95Oocyte meiosis_Homo sapiens_hsa041140.37863941
96Chemical carcinogenesis_Homo sapiens_hsa052040.37412150
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37318152
98Carbon metabolism_Homo sapiens_hsa012000.37088347
99DNA replication_Homo sapiens_hsa030300.36151865
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.34088400

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