

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 6.71937728 |
| 2 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 5.79013779 |
| 3 | piRNA metabolic process (GO:0034587) | 5.04218756 |
| 4 | cellular ketone body metabolic process (GO:0046950) | 4.83884854 |
| 5 | regulation of acrosome reaction (GO:0060046) | 4.56080610 |
| 6 | regulation of translational termination (GO:0006449) | 4.52359935 |
| 7 | ether lipid metabolic process (GO:0046485) | 4.49455076 |
| 8 | opioid receptor signaling pathway (GO:0038003) | 4.44461422 |
| 9 | cullin deneddylation (GO:0010388) | 4.42315566 |
| 10 | branched-chain amino acid catabolic process (GO:0009083) | 4.32417629 |
| 11 | negative regulation of neurological system process (GO:0031645) | 4.30999019 |
| 12 | adult feeding behavior (GO:0008343) | 4.30129241 |
| 13 | ketone body metabolic process (GO:1902224) | 4.25162380 |
| 14 | behavioral response to ethanol (GO:0048149) | 4.18128640 |
| 15 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 4.14235636 |
| 16 | heparin biosynthetic process (GO:0030210) | 4.02062909 |
| 17 | heparin metabolic process (GO:0030202) | 4.02062909 |
| 18 | rRNA modification (GO:0000154) | 4.00854663 |
| 19 | rRNA methylation (GO:0031167) | 3.97389004 |
| 20 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.95472470 |
| 21 | proteasome assembly (GO:0043248) | 3.94698631 |
| 22 | ATP synthesis coupled proton transport (GO:0015986) | 3.94341033 |
| 23 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.94341033 |
| 24 | DNA deamination (GO:0045006) | 3.90467477 |
| 25 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.87165390 |
| 26 | negative regulation of cAMP-mediated signaling (GO:0043951) | 3.85077558 |
| 27 | tyrosine phosphorylation of STAT protein (GO:0007260) | 3.82279127 |
| 28 | protein deneddylation (GO:0000338) | 3.76224890 |
| 29 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 3.70467686 |
| 30 | DNA double-strand break processing (GO:0000729) | 3.62975868 |
| 31 | behavioral response to nicotine (GO:0035095) | 3.61244012 |
| 32 | respiratory chain complex IV assembly (GO:0008535) | 3.60551097 |
| 33 | ncRNA catabolic process (GO:0034661) | 3.55025674 |
| 34 | dopamine transport (GO:0015872) | 3.54350331 |
| 35 | pseudouridine synthesis (GO:0001522) | 3.49738825 |
| 36 | phospholipid homeostasis (GO:0055091) | 3.46893668 |
| 37 | phosphatidylserine acyl-chain remodeling (GO:0036150) | 3.45896573 |
| 38 | branched-chain amino acid metabolic process (GO:0009081) | 3.42352843 |
| 39 | cytochrome complex assembly (GO:0017004) | 3.38984503 |
| 40 | positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968) | 3.33294373 |
| 41 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.33214606 |
| 42 | regulation of protein glycosylation (GO:0060049) | 3.23888154 |
| 43 | spindle assembly involved in mitosis (GO:0090307) | 3.23466821 |
| 44 | negative regulation of calcium ion-dependent exocytosis (GO:0045955) | 3.22085083 |
| 45 | indolalkylamine metabolic process (GO:0006586) | 3.21260895 |
| 46 | signal peptide processing (GO:0006465) | 3.18614977 |
| 47 | retinal cone cell development (GO:0046549) | 3.17806664 |
| 48 | regulation of centrosome cycle (GO:0046605) | 3.15235568 |
| 49 | sphingoid metabolic process (GO:0046519) | 3.12733714 |
| 50 | regulation of glucokinase activity (GO:0033131) | 3.12631575 |
| 51 | regulation of hexokinase activity (GO:1903299) | 3.12631575 |
| 52 | glycerophospholipid catabolic process (GO:0046475) | 3.11946391 |
| 53 | positive regulation of cAMP-mediated signaling (GO:0043950) | 3.09609101 |
| 54 | N-terminal protein amino acid acetylation (GO:0006474) | 3.08151639 |
| 55 | keratinocyte development (GO:0003334) | 3.03339062 |
| 56 | negative regulation of thymocyte apoptotic process (GO:0070244) | 3.00355208 |
| 57 | preassembly of GPI anchor in ER membrane (GO:0016254) | 3.00106369 |
| 58 | positive regulation of Rho protein signal transduction (GO:0035025) | 2.99649887 |
| 59 | DNA damage response, detection of DNA damage (GO:0042769) | 2.99440337 |
| 60 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.97623644 |
| 61 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 2.96884422 |
| 62 | response to pheromone (GO:0019236) | 2.95323894 |
| 63 | protein complex biogenesis (GO:0070271) | 2.92625041 |
| 64 | sphingosine metabolic process (GO:0006670) | 2.90601374 |
| 65 | regulation of bile acid biosynthetic process (GO:0070857) | 2.89748897 |
| 66 | mRNA cleavage (GO:0006379) | 2.88409556 |
| 67 | regulation of female gonad development (GO:2000194) | 2.88039214 |
| 68 | ovulation cycle (GO:0042698) | 2.88036057 |
| 69 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.87816519 |
| 70 | valine metabolic process (GO:0006573) | 2.86173914 |
| 71 | regulation of transmission of nerve impulse (GO:0051969) | 2.86157020 |
| 72 | diol metabolic process (GO:0034311) | 2.85174559 |
| 73 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.83344923 |
| 74 | detection of chemical stimulus involved in sensory perception of smell (GO:0050911) | 2.82975749 |
| 75 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.81812834 |
| 76 | negative regulation of interleukin-1 beta production (GO:0032691) | 2.80163140 |
| 77 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.79858854 |
| 78 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.79704530 |
| 79 | glycerol ether metabolic process (GO:0006662) | 2.79318161 |
| 80 | DNA replication-dependent nucleosome organization (GO:0034723) | 2.79164202 |
| 81 | DNA replication-dependent nucleosome assembly (GO:0006335) | 2.79164202 |
| 82 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 2.77140592 |
| 83 | replication fork processing (GO:0031297) | 2.76942327 |
| 84 | lactate metabolic process (GO:0006089) | 2.74133563 |
| 85 | tryptophan metabolic process (GO:0006568) | 2.71900856 |
| 86 | otic vesicle formation (GO:0030916) | 2.70919888 |
| 87 | termination of RNA polymerase III transcription (GO:0006386) | 2.67757631 |
| 88 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.67757631 |
| 89 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.64796156 |
| 90 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 2.64613629 |
| 91 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 2.64613629 |
| 92 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 2.64613629 |
| 93 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.63760524 |
| 94 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.63015828 |
| 95 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.63015828 |
| 96 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.63015828 |
| 97 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.62681140 |
| 98 | mitotic sister chromatid segregation (GO:0000070) | 2.62283023 |
| 99 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.61289518 |
| 100 | protein neddylation (GO:0045116) | 2.60865340 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VDR_22108803_ChIP-Seq_LS180_Human | 4.22761159 |
| 2 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.54923145 |
| 3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.42358428 |
| 4 | ZNF274_21170338_ChIP-Seq_K562_Hela | 3.26489865 |
| 5 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.24444410 |
| 6 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.89677010 |
| 7 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 2.78426087 |
| 8 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.54635075 |
| 9 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.52529420 |
| 10 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.47159034 |
| 11 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.25351056 |
| 12 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 2.04697025 |
| 13 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.01490179 |
| 14 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.99785493 |
| 15 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.96822367 |
| 16 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.93827488 |
| 17 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.88332701 |
| 18 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.87717278 |
| 19 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.87086410 |
| 20 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.83386304 |
| 21 | FUS_26573619_Chip-Seq_HEK293_Human | 1.83330961 |
| 22 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.80199604 |
| 23 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.78932650 |
| 24 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.75264688 |
| 25 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.74577538 |
| 26 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.72380818 |
| 27 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.69803566 |
| 28 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.69803566 |
| 29 | EWS_26573619_Chip-Seq_HEK293_Human | 1.69193826 |
| 30 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.63149090 |
| 31 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.62975946 |
| 32 | P300_19829295_ChIP-Seq_ESCs_Human | 1.60376695 |
| 33 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.56183407 |
| 34 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.51192789 |
| 35 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.50152936 |
| 36 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.47467942 |
| 37 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.47201018 |
| 38 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.47115700 |
| 39 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.46972164 |
| 40 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.46972164 |
| 41 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.46725506 |
| 42 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.44488088 |
| 43 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.44488088 |
| 44 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.42729610 |
| 45 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.41735644 |
| 46 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.40922017 |
| 47 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.40589309 |
| 48 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.39816891 |
| 49 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.37428378 |
| 50 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.35830900 |
| 51 | TCF4_23295773_ChIP-Seq_U87_Human | 1.34470006 |
| 52 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.33362114 |
| 53 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.32077281 |
| 54 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.30641868 |
| 55 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.30547007 |
| 56 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.27682611 |
| 57 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.26066244 |
| 58 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.24705545 |
| 59 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.22753052 |
| 60 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.22013887 |
| 61 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.21579677 |
| 62 | AR_25329375_ChIP-Seq_VCAP_Human | 1.21197233 |
| 63 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.21083131 |
| 64 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.19285840 |
| 65 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.18711964 |
| 66 | CDX2_22108803_ChIP-Seq_LS180_Human | 1.14725068 |
| 67 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.12747301 |
| 68 | HOXB7_26014856_ChIP-Seq_BT474_Human | 1.12038507 |
| 69 | NCOR_22424771_ChIP-Seq_293T_Human | 1.11943836 |
| 70 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.11933475 |
| 71 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.09083884 |
| 72 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.08697266 |
| 73 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.08696482 |
| 74 | P300_18555785_Chip-Seq_ESCs_Mouse | 1.07986438 |
| 75 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.07777968 |
| 76 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.07777968 |
| 77 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.07657778 |
| 78 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.07178825 |
| 79 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.07150229 |
| 80 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 1.07099698 |
| 81 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.05911448 |
| 82 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.03945745 |
| 83 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 1.02773069 |
| 84 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.00994331 |
| 85 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.00649834 |
| 86 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 0.99984958 |
| 87 | STAT3_23295773_ChIP-Seq_U87_Human | 0.99697009 |
| 88 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.99126420 |
| 89 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.98352370 |
| 90 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 0.98308147 |
| 91 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.97382935 |
| 92 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 0.96645373 |
| 93 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 0.96299480 |
| 94 | DCP1A_22483619_ChIP-Seq_HELA_Human | 0.95944831 |
| 95 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.95943577 |
| 96 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.95792087 |
| 97 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.95669365 |
| 98 | GABP_19822575_ChIP-Seq_HepG2_Human | 0.95130045 |
| 99 | P53_22387025_ChIP-Seq_ESCs_Mouse | 0.94190241 |
| 100 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 0.93890288 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001968_abnormal_touch/_nociception | 4.00389646 |
| 2 | MP0009046_muscle_twitch | 3.41967913 |
| 3 | MP0005645_abnormal_hypothalamus_physiol | 3.40369089 |
| 4 | MP0002876_abnormal_thyroid_physiology | 3.24390248 |
| 5 | MP0006035_abnormal_mitochondrial_morpho | 3.23867301 |
| 6 | MP0008877_abnormal_DNA_methylation | 3.08678353 |
| 7 | MP0005646_abnormal_pituitary_gland | 3.01885963 |
| 8 | MP0003195_calcinosis | 2.70607722 |
| 9 | MP0009780_abnormal_chondrocyte_physiolo | 2.68336651 |
| 10 | MP0002254_reproductive_system_inflammat | 2.43085116 |
| 11 | MP0008872_abnormal_physiological_respon | 2.29116641 |
| 12 | MP0003880_abnormal_central_pattern | 2.28622159 |
| 13 | MP0003315_abnormal_perineum_morphology | 2.23708185 |
| 14 | MP0004147_increased_porphyrin_level | 2.22287347 |
| 15 | MP0001348_abnormal_lacrimal_gland | 2.19542407 |
| 16 | MP0002272_abnormal_nervous_system | 2.13143957 |
| 17 | MP0006036_abnormal_mitochondrial_physio | 2.11398500 |
| 18 | MP0005084_abnormal_gallbladder_morpholo | 2.00444768 |
| 19 | MP0006292_abnormal_olfactory_placode | 1.99907641 |
| 20 | MP0010386_abnormal_urinary_bladder | 1.95884489 |
| 21 | MP0005551_abnormal_eye_electrophysiolog | 1.88841779 |
| 22 | MP0003718_maternal_effect | 1.81583780 |
| 23 | MP0001984_abnormal_olfaction | 1.79004452 |
| 24 | MP0009745_abnormal_behavioral_response | 1.71149597 |
| 25 | MP0002736_abnormal_nociception_after | 1.70626994 |
| 26 | MP0005167_abnormal_blood-brain_barrier | 1.65673314 |
| 27 | MP0004215_abnormal_myocardial_fiber | 1.53935107 |
| 28 | MP0000013_abnormal_adipose_tissue | 1.53422675 |
| 29 | MP0005187_abnormal_penis_morphology | 1.49650361 |
| 30 | MP0002638_abnormal_pupillary_reflex | 1.47119693 |
| 31 | MP0003567_abnormal_fetal_cardiomyocyte | 1.44569673 |
| 32 | MP0004742_abnormal_vestibular_system | 1.43355588 |
| 33 | MP0002277_abnormal_respiratory_mucosa | 1.41754085 |
| 34 | MP0009697_abnormal_copulation | 1.40500322 |
| 35 | MP0009840_abnormal_foam_cell | 1.39979506 |
| 36 | MP0005083_abnormal_biliary_tract | 1.39851016 |
| 37 | MP0008875_abnormal_xenobiotic_pharmacok | 1.39681838 |
| 38 | MP0005253_abnormal_eye_physiology | 1.34399188 |
| 39 | MP0000427_abnormal_hair_cycle | 1.32222467 |
| 40 | MP0003191_abnormal_cellular_cholesterol | 1.30825911 |
| 41 | MP0003011_delayed_dark_adaptation | 1.27735089 |
| 42 | MP0006276_abnormal_autonomic_nervous | 1.27361882 |
| 43 | MP0008058_abnormal_DNA_repair | 1.26615957 |
| 44 | MP0002102_abnormal_ear_morphology | 1.26152373 |
| 45 | MP0002733_abnormal_thermal_nociception | 1.25630685 |
| 46 | MP0005379_endocrine/exocrine_gland_phen | 1.24689115 |
| 47 | MP0002067_abnormal_sensory_capabilities | 1.17081364 |
| 48 | MP0001970_abnormal_pain_threshold | 1.16853062 |
| 49 | MP0001486_abnormal_startle_reflex | 1.16268638 |
| 50 | MP0010234_abnormal_vibrissa_follicle | 1.14620210 |
| 51 | MP0006072_abnormal_retinal_apoptosis | 1.14397807 |
| 52 | MP0004145_abnormal_muscle_electrophysio | 1.12549070 |
| 53 | MP0004957_abnormal_blastocyst_morpholog | 1.11643056 |
| 54 | MP0003786_premature_aging | 1.09189860 |
| 55 | MP0010094_abnormal_chromosome_stability | 1.08771843 |
| 56 | MP0002837_dystrophic_cardiac_calcinosis | 1.07952049 |
| 57 | MP0003633_abnormal_nervous_system | 1.06439171 |
| 58 | MP0003868_abnormal_feces_composition | 1.06430660 |
| 59 | MP0005360_urolithiasis | 1.05984747 |
| 60 | MP0001664_abnormal_digestion | 1.05327318 |
| 61 | MP0001986_abnormal_taste_sensitivity | 1.02327873 |
| 62 | MP0003693_abnormal_embryo_hatching | 1.00885115 |
| 63 | MP0004085_abnormal_heartbeat | 0.99336697 |
| 64 | MP0001501_abnormal_sleep_pattern | 0.98812735 |
| 65 | MP0003638_abnormal_response/metabolism_ | 0.97746877 |
| 66 | MP0000358_abnormal_cell_content/ | 0.95431905 |
| 67 | MP0002229_neurodegeneration | 0.94060953 |
| 68 | MP0002064_seizures | 0.92742486 |
| 69 | MP0003635_abnormal_synaptic_transmissio | 0.89958916 |
| 70 | MP0001919_abnormal_reproductive_system | 0.88820768 |
| 71 | MP0005310_abnormal_salivary_gland | 0.86768895 |
| 72 | MP0003787_abnormal_imprinting | 0.86305496 |
| 73 | MP0000230_abnormal_systemic_arterial | 0.84931792 |
| 74 | MP0005332_abnormal_amino_acid | 0.84453050 |
| 75 | MP0002160_abnormal_reproductive_system | 0.80024542 |
| 76 | MP0000613_abnormal_salivary_gland | 0.79089955 |
| 77 | MP0009764_decreased_sensitivity_to | 0.78090313 |
| 78 | MP0003186_abnormal_redox_activity | 0.77734428 |
| 79 | MP0000538_abnormal_urinary_bladder | 0.77076683 |
| 80 | MP0005636_abnormal_mineral_homeostasis | 0.73825273 |
| 81 | MP0004036_abnormal_muscle_relaxation | 0.73249119 |
| 82 | MP0005410_abnormal_fertilization | 0.70662381 |
| 83 | MP0001944_abnormal_pancreas_morphology | 0.70432660 |
| 84 | MP0001929_abnormal_gametogenesis | 0.67707632 |
| 85 | MP0001440_abnormal_grooming_behavior | 0.67622080 |
| 86 | MP0009333_abnormal_splenocyte_physiolog | 0.66762866 |
| 87 | MP0002572_abnormal_emotion/affect_behav | 0.66174795 |
| 88 | MP0004043_abnormal_pH_regulation | 0.65928827 |
| 89 | MP0002557_abnormal_social/conspecific_i | 0.65200249 |
| 90 | MP0008775_abnormal_heart_ventricle | 0.65180984 |
| 91 | MP0004782_abnormal_surfactant_physiolog | 0.65128680 |
| 92 | MP0002751_abnormal_autonomic_nervous | 0.65023358 |
| 93 | MP0005389_reproductive_system_phenotype | 0.64780046 |
| 94 | MP0001485_abnormal_pinna_reflex | 0.63803014 |
| 95 | MP0002938_white_spotting | 0.63267103 |
| 96 | MP0003941_abnormal_skin_development | 0.60673961 |
| 97 | MP0002210_abnormal_sex_determination | 0.60647208 |
| 98 | MP0002735_abnormal_chemical_nociception | 0.59424135 |
| 99 | MP0001529_abnormal_vocalization | 0.58910627 |
| 100 | MP0001905_abnormal_dopamine_level | 0.58431302 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Thyroid-stimulating hormone excess (HP:0002925) | 5.64144487 |
| 2 | 3-Methylglutaconic aciduria (HP:0003535) | 4.34916074 |
| 3 | Progressive inability to walk (HP:0002505) | 3.96830871 |
| 4 | Pancreatic islet-cell hyperplasia (HP:0004510) | 3.44245217 |
| 5 | Abnormality of the pancreatic islet cells (HP:0006476) | 3.38863981 |
| 6 | Abnormality of endocrine pancreas physiology (HP:0012093) | 3.38863981 |
| 7 | Chronic hepatic failure (HP:0100626) | 3.38699716 |
| 8 | Intestinal atresia (HP:0011100) | 3.32242406 |
| 9 | Methylmalonic acidemia (HP:0002912) | 3.26179660 |
| 10 | Focal motor seizures (HP:0011153) | 3.13216110 |
| 11 | Increased CSF lactate (HP:0002490) | 3.12507478 |
| 12 | Acute necrotizing encephalopathy (HP:0006965) | 3.10884243 |
| 13 | Hypothermia (HP:0002045) | 3.05083348 |
| 14 | Inability to walk (HP:0002540) | 3.02654053 |
| 15 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.95670787 |
| 16 | Epileptic encephalopathy (HP:0200134) | 2.95075297 |
| 17 | Methylmalonic aciduria (HP:0012120) | 2.92951634 |
| 18 | Volvulus (HP:0002580) | 2.92945304 |
| 19 | Progressive macrocephaly (HP:0004481) | 2.89288954 |
| 20 | Broad alveolar ridges (HP:0000187) | 2.85050015 |
| 21 | Abnormality of the labia minora (HP:0012880) | 2.80043355 |
| 22 | Mesangial abnormality (HP:0001966) | 2.79455626 |
| 23 | Increased serum pyruvate (HP:0003542) | 2.77423786 |
| 24 | Large eyes (HP:0001090) | 2.72326108 |
| 25 | Acute encephalopathy (HP:0006846) | 2.71031113 |
| 26 | Agitation (HP:0000713) | 2.70930614 |
| 27 | Mitochondrial inheritance (HP:0001427) | 2.70797484 |
| 28 | Large for gestational age (HP:0001520) | 2.69157293 |
| 29 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.60614186 |
| 30 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.59223087 |
| 31 | Dicarboxylic aciduria (HP:0003215) | 2.59223087 |
| 32 | Sensory axonal neuropathy (HP:0003390) | 2.59039535 |
| 33 | Prominent metopic ridge (HP:0005487) | 2.58659801 |
| 34 | Abnormality of glycolysis (HP:0004366) | 2.57699284 |
| 35 | Abnormality of lateral ventricle (HP:0030047) | 2.56492440 |
| 36 | Gaze-evoked nystagmus (HP:0000640) | 2.56244454 |
| 37 | Atonic seizures (HP:0010819) | 2.50863802 |
| 38 | Abnormality of vitamin B metabolism (HP:0004340) | 2.48317539 |
| 39 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.47956908 |
| 40 | Abnormality of methionine metabolism (HP:0010901) | 2.47110334 |
| 41 | Tubular atrophy (HP:0000092) | 2.39921655 |
| 42 | Broad-based gait (HP:0002136) | 2.36062680 |
| 43 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 2.33247265 |
| 44 | Abnormal pancreas size (HP:0012094) | 2.31746294 |
| 45 | Abnormality of the renal cortex (HP:0011035) | 2.30396249 |
| 46 | Increased serum lactate (HP:0002151) | 2.29993149 |
| 47 | Poor head control (HP:0002421) | 2.27951223 |
| 48 | Asplenia (HP:0001746) | 2.25104497 |
| 49 | Hypomagnesemia (HP:0002917) | 2.22912231 |
| 50 | Aplastic anemia (HP:0001915) | 2.21138649 |
| 51 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 2.20001042 |
| 52 | Pendular nystagmus (HP:0012043) | 2.19574721 |
| 53 | Optic nerve hypoplasia (HP:0000609) | 2.19303282 |
| 54 | Dialeptic seizures (HP:0011146) | 2.19098252 |
| 55 | Hypoproteinemia (HP:0003075) | 2.17083098 |
| 56 | Hypoplasia of the uterus (HP:0000013) | 2.16513923 |
| 57 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.14121227 |
| 58 | Poor speech (HP:0002465) | 2.12245062 |
| 59 | Abnormality of midbrain morphology (HP:0002418) | 2.12096648 |
| 60 | Molar tooth sign on MRI (HP:0002419) | 2.12096648 |
| 61 | Abnormality of the ileum (HP:0001549) | 2.08049570 |
| 62 | Limb dystonia (HP:0002451) | 2.07218204 |
| 63 | Febrile seizures (HP:0002373) | 2.06793078 |
| 64 | Abnormality of the metopic suture (HP:0005556) | 2.06696393 |
| 65 | Abnormality of homocysteine metabolism (HP:0010919) | 2.06634669 |
| 66 | Homocystinuria (HP:0002156) | 2.06634669 |
| 67 | Hyperglycinuria (HP:0003108) | 2.03919651 |
| 68 | Ketoacidosis (HP:0001993) | 2.03609268 |
| 69 | Hepatic necrosis (HP:0002605) | 2.02926768 |
| 70 | Renal cortical cysts (HP:0000803) | 2.02650973 |
| 71 | Polydipsia (HP:0001959) | 2.01432497 |
| 72 | Abnormal drinking behavior (HP:0030082) | 2.01432497 |
| 73 | Status epilepticus (HP:0002133) | 2.00800138 |
| 74 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 2.00697079 |
| 75 | Degeneration of anterior horn cells (HP:0002398) | 2.00520195 |
| 76 | Abnormality of the anterior horn cell (HP:0006802) | 2.00520195 |
| 77 | Pancreatic cysts (HP:0001737) | 1.99938640 |
| 78 | Abnormality of macular pigmentation (HP:0008002) | 1.97657525 |
| 79 | Symptomatic seizures (HP:0011145) | 1.93899682 |
| 80 | Hepatocellular necrosis (HP:0001404) | 1.93807834 |
| 81 | Absence seizures (HP:0002121) | 1.93525446 |
| 82 | Increased hepatocellular lipid droplets (HP:0006565) | 1.92730100 |
| 83 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.91698472 |
| 84 | Cerebral edema (HP:0002181) | 1.90300734 |
| 85 | Metabolic alkalosis (HP:0200114) | 1.90208609 |
| 86 | Pancreatic fibrosis (HP:0100732) | 1.90082698 |
| 87 | Abnormality of the aortic arch (HP:0012303) | 1.89381528 |
| 88 | Progressive external ophthalmoplegia (HP:0000590) | 1.88543595 |
| 89 | Progressive muscle weakness (HP:0003323) | 1.88392555 |
| 90 | Congenital ichthyosiform erythroderma (HP:0007431) | 1.87487388 |
| 91 | Congenital stationary night blindness (HP:0007642) | 1.87127216 |
| 92 | Lipid accumulation in hepatocytes (HP:0006561) | 1.86879466 |
| 93 | Optic disc pallor (HP:0000543) | 1.85640964 |
| 94 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.85425546 |
| 95 | Amblyopia (HP:0000646) | 1.85144281 |
| 96 | Carpal bone hypoplasia (HP:0001498) | 1.82842166 |
| 97 | Abnormality of the pons (HP:0007361) | 1.77680965 |
| 98 | Fatigue (HP:0012378) | 1.77456523 |
| 99 | Hypoplasia of the pons (HP:0012110) | 1.77048693 |
| 100 | Polyuria (HP:0000103) | 1.75377013 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MST4 | 5.72854449 |
| 2 | FRK | 4.56688032 |
| 3 | ADRBK2 | 4.39411575 |
| 4 | EIF2AK3 | 4.22235111 |
| 5 | MAP4K2 | 3.47916508 |
| 6 | TSSK6 | 3.40397037 |
| 7 | DYRK3 | 3.15579968 |
| 8 | MAP3K12 | 2.92002984 |
| 9 | BUB1 | 2.68235085 |
| 10 | CLK1 | 2.41824866 |
| 11 | NEK2 | 2.41109779 |
| 12 | ZAK | 2.17136857 |
| 13 | NEK1 | 1.97162307 |
| 14 | PINK1 | 1.91626831 |
| 15 | STK3 | 1.79517672 |
| 16 | VRK2 | 1.73606584 |
| 17 | PLK3 | 1.63399787 |
| 18 | STK16 | 1.59189018 |
| 19 | NUAK1 | 1.52306584 |
| 20 | PBK | 1.41961676 |
| 21 | TTK | 1.37445529 |
| 22 | STK39 | 1.32089505 |
| 23 | PLK2 | 1.26746001 |
| 24 | GRK1 | 1.26378854 |
| 25 | EIF2AK1 | 1.20430292 |
| 26 | TLK1 | 1.19354291 |
| 27 | OXSR1 | 1.18688455 |
| 28 | PRKCG | 1.16039648 |
| 29 | PDK2 | 1.12791949 |
| 30 | CASK | 1.10445545 |
| 31 | WNK3 | 0.99882616 |
| 32 | IRAK1 | 0.99661443 |
| 33 | ADRBK1 | 0.97265323 |
| 34 | WNK4 | 0.96834360 |
| 35 | GRK5 | 0.93523000 |
| 36 | FGFR2 | 0.92826823 |
| 37 | TRIM28 | 0.91286161 |
| 38 | TNIK | 0.90446718 |
| 39 | MAP3K2 | 0.90051215 |
| 40 | PTK6 | 0.86858299 |
| 41 | PRKCE | 0.83831539 |
| 42 | STK10 | 0.83508685 |
| 43 | CSNK1G2 | 0.81445491 |
| 44 | VRK1 | 0.77857383 |
| 45 | EIF2AK2 | 0.76432123 |
| 46 | MAPKAPK5 | 0.75347272 |
| 47 | CSNK1G3 | 0.72377856 |
| 48 | STK38L | 0.70175423 |
| 49 | TAF1 | 0.69558474 |
| 50 | MAP2K6 | 0.69130526 |
| 51 | MYLK | 0.67911533 |
| 52 | RPS6KA4 | 0.67016833 |
| 53 | PNCK | 0.66662104 |
| 54 | NEK9 | 0.66648277 |
| 55 | PHKG2 | 0.66163440 |
| 56 | PHKG1 | 0.66163440 |
| 57 | PRKCI | 0.65060573 |
| 58 | MKNK2 | 0.64611452 |
| 59 | WEE1 | 0.60252916 |
| 60 | MAP3K9 | 0.60161147 |
| 61 | PAK3 | 0.57305069 |
| 62 | PLK1 | 0.56863191 |
| 63 | INSRR | 0.55434806 |
| 64 | TAOK1 | 0.55137690 |
| 65 | MKNK1 | 0.54690823 |
| 66 | ATR | 0.54531472 |
| 67 | CSNK1G1 | 0.54308571 |
| 68 | PLK4 | 0.54219264 |
| 69 | MAPK11 | 0.53478562 |
| 70 | BMPR1B | 0.52989959 |
| 71 | TXK | 0.52802354 |
| 72 | DMPK | 0.49003902 |
| 73 | PASK | 0.45041977 |
| 74 | MAP3K3 | 0.43632794 |
| 75 | MAP3K8 | 0.42718698 |
| 76 | MINK1 | 0.42052122 |
| 77 | AKT2 | 0.40786473 |
| 78 | CSNK1A1L | 0.40624689 |
| 79 | BCR | 0.39572602 |
| 80 | AURKB | 0.39114167 |
| 81 | SRPK1 | 0.38320704 |
| 82 | MAPK13 | 0.37694570 |
| 83 | CDK19 | 0.36934270 |
| 84 | LIMK1 | 0.35063117 |
| 85 | TGFBR1 | 0.34962404 |
| 86 | CAMK2A | 0.31895347 |
| 87 | CSNK1A1 | 0.30928571 |
| 88 | CCNB1 | 0.28532210 |
| 89 | ATM | 0.27140724 |
| 90 | PRKCA | 0.27094507 |
| 91 | PRKG1 | 0.24742299 |
| 92 | CSNK2A2 | 0.23736907 |
| 93 | PRKCB | 0.23082807 |
| 94 | RPS6KA5 | 0.22554466 |
| 95 | CSNK2A1 | 0.22027057 |
| 96 | ALK | 0.21350212 |
| 97 | CSNK1E | 0.19110780 |
| 98 | CHEK1 | 0.17972010 |
| 99 | TIE1 | 0.17318894 |
| 100 | MAPKAPK3 | 0.16877236 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 3.74895890 |
| 2 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 3.23905541 |
| 3 | Protein export_Homo sapiens_hsa03060 | 2.79124748 |
| 4 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.51438582 |
| 5 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.50533795 |
| 6 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.34022790 |
| 7 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 2.32820800 |
| 8 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.29128102 |
| 9 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.21362790 |
| 10 | Parkinsons disease_Homo sapiens_hsa05012 | 2.20989725 |
| 11 | Olfactory transduction_Homo sapiens_hsa04740 | 2.17827798 |
| 12 | Basal transcription factors_Homo sapiens_hsa03022 | 2.16675517 |
| 13 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.96543919 |
| 14 | Homologous recombination_Homo sapiens_hsa03440 | 1.92514967 |
| 15 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.86600727 |
| 16 | Phototransduction_Homo sapiens_hsa04744 | 1.84200794 |
| 17 | RNA polymerase_Homo sapiens_hsa03020 | 1.73930352 |
| 18 | RNA degradation_Homo sapiens_hsa03018 | 1.65847649 |
| 19 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.61383380 |
| 20 | Huntingtons disease_Homo sapiens_hsa05016 | 1.60229731 |
| 21 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.59792493 |
| 22 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.56735812 |
| 23 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.56594292 |
| 24 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.53583577 |
| 25 | Fatty acid degradation_Homo sapiens_hsa00071 | 1.52357828 |
| 26 | Alzheimers disease_Homo sapiens_hsa05010 | 1.49515306 |
| 27 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.48971076 |
| 28 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.43663191 |
| 29 | Morphine addiction_Homo sapiens_hsa05032 | 1.42369380 |
| 30 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.41361637 |
| 31 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.39562630 |
| 32 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.34785552 |
| 33 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.30593923 |
| 34 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.24059691 |
| 35 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.23212241 |
| 36 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.22424861 |
| 37 | Long-term depression_Homo sapiens_hsa04730 | 1.20504799 |
| 38 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.16128107 |
| 39 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.13203943 |
| 40 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.10794604 |
| 41 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.09367253 |
| 42 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.04395521 |
| 43 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.03106981 |
| 44 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.02549067 |
| 45 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.02216126 |
| 46 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.01434375 |
| 47 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.99423674 |
| 48 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.92633482 |
| 49 | Nicotine addiction_Homo sapiens_hsa05033 | 0.89052535 |
| 50 | RNA transport_Homo sapiens_hsa03013 | 0.88530947 |
| 51 | Peroxisome_Homo sapiens_hsa04146 | 0.85415461 |
| 52 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.82230902 |
| 53 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.80993592 |
| 54 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.79427003 |
| 55 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.78471889 |
| 56 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.77711024 |
| 57 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.76513953 |
| 58 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.76283180 |
| 59 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.75449963 |
| 60 | Circadian entrainment_Homo sapiens_hsa04713 | 0.75375170 |
| 61 | Purine metabolism_Homo sapiens_hsa00230 | 0.73591539 |
| 62 | Mineral absorption_Homo sapiens_hsa04978 | 0.71599776 |
| 63 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.70581854 |
| 64 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.70577554 |
| 65 | Mismatch repair_Homo sapiens_hsa03430 | 0.69663236 |
| 66 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.69432661 |
| 67 | Metabolic pathways_Homo sapiens_hsa01100 | 0.68505317 |
| 68 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.68078502 |
| 69 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.68077425 |
| 70 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.67641959 |
| 71 | ABC transporters_Homo sapiens_hsa02010 | 0.65026766 |
| 72 | Insulin secretion_Homo sapiens_hsa04911 | 0.62871096 |
| 73 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.60950440 |
| 74 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.59132786 |
| 75 | GABAergic synapse_Homo sapiens_hsa04727 | 0.58343195 |
| 76 | Circadian rhythm_Homo sapiens_hsa04710 | 0.57883706 |
| 77 | Retinol metabolism_Homo sapiens_hsa00830 | 0.56893161 |
| 78 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.56261582 |
| 79 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.52307685 |
| 80 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.52030295 |
| 81 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.51059731 |
| 82 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.50994762 |
| 83 | Taste transduction_Homo sapiens_hsa04742 | 0.49695937 |
| 84 | Salivary secretion_Homo sapiens_hsa04970 | 0.47236404 |
| 85 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.45344916 |
| 86 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.44673723 |
| 87 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.44345980 |
| 88 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.44103558 |
| 89 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.43965007 |
| 90 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.43611534 |
| 91 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.41996217 |
| 92 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.41405692 |
| 93 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.38287210 |
| 94 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.38040677 |
| 95 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.37863941 |
| 96 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.37412150 |
| 97 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.37318152 |
| 98 | Carbon metabolism_Homo sapiens_hsa01200 | 0.37088347 |
| 99 | DNA replication_Homo sapiens_hsa03030 | 0.36151865 |
| 100 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.34088400 |

