PRDX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tricarboxylic acid cycle (GO:0006099)5.71540874
2lysine metabolic process (GO:0006553)5.40746064
3lysine catabolic process (GO:0006554)5.40746064
4oxidative phosphorylation (GO:0006119)4.97056997
5NADH metabolic process (GO:0006734)4.94035078
6protoporphyrinogen IX metabolic process (GO:0046501)4.75939176
7protoporphyrinogen IX biosynthetic process (GO:0006782)4.75646638
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.67872964
9oxaloacetate metabolic process (GO:0006107)4.57767015
10establishment of integrated proviral latency (GO:0075713)4.45522130
11heme biosynthetic process (GO:0006783)4.39773674
12succinate metabolic process (GO:0006105)4.35578966
13negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.34859877
14cullin deneddylation (GO:0010388)4.33831327
152-oxoglutarate metabolic process (GO:0006103)4.28012110
16ribosome assembly (GO:0042255)4.22163905
17regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.21662930
18CENP-A containing nucleosome assembly (GO:0034080)4.18036399
19chromatin remodeling at centromere (GO:0031055)4.17549335
20valine metabolic process (GO:0006573)4.16597432
21energy coupled proton transport, down electrochemical gradient (GO:0015985)4.16341274
22ATP synthesis coupled proton transport (GO:0015986)4.16341274
23branched-chain amino acid catabolic process (GO:0009083)4.13338376
24positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.05151144
25aspartate family amino acid catabolic process (GO:0009068)4.03806383
26respiratory electron transport chain (GO:0022904)4.03764984
27porphyrin-containing compound biosynthetic process (GO:0006779)4.02509248
28protein deneddylation (GO:0000338)3.99505539
29negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.96913061
30negative regulation of ligase activity (GO:0051352)3.96913061
31heme metabolic process (GO:0042168)3.96004862
32anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.95055646
33regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.94511494
34tricarboxylic acid metabolic process (GO:0072350)3.94283544
35electron transport chain (GO:0022900)3.93098967
36branched-chain amino acid metabolic process (GO:0009081)3.92843698
37fatty acid beta-oxidation (GO:0006635)3.90310461
38establishment of protein localization to mitochondrial membrane (GO:0090151)3.90238335
39mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.85444985
40DNA double-strand break processing (GO:0000729)3.84764496
41purine nucleobase biosynthetic process (GO:0009113)3.82478486
42regulation of cellular amino acid metabolic process (GO:0006521)3.82090821
43glyoxylate metabolic process (GO:0046487)3.80277505
44IMP biosynthetic process (GO:0006188)3.77446631
45respiratory chain complex IV assembly (GO:0008535)3.68192639
46tetrapyrrole biosynthetic process (GO:0033014)3.67569031
47lactate metabolic process (GO:0006089)3.66963649
48DNA replication checkpoint (GO:0000076)3.63325551
49regulation of acyl-CoA biosynthetic process (GO:0050812)3.63070393
50erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.59048345
51L-phenylalanine metabolic process (GO:0006558)3.59048345
52cysteine metabolic process (GO:0006534)3.58776043
53porphyrin-containing compound metabolic process (GO:0006778)3.57329109
54acetyl-CoA metabolic process (GO:0006084)3.55509076
55L-phenylalanine catabolic process (GO:0006559)3.54784598
56erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.54784598
57histone exchange (GO:0043486)3.54038546
58fatty acid oxidation (GO:0019395)3.53040012
59ethanol oxidation (GO:0006069)3.52951305
60DNA strand elongation involved in DNA replication (GO:0006271)3.51099673
61mitotic metaphase plate congression (GO:0007080)3.50643197
62DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.50042483
63signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.49828072
64signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.49828072
65signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.49828072
66establishment of viral latency (GO:0019043)3.48052367
67positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.46240477
68intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.46152277
69signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.46152277
70aerobic respiration (GO:0009060)3.46092306
71lipid oxidation (GO:0034440)3.45845303
72telomere maintenance via semi-conservative replication (GO:0032201)3.44068120
73fatty acid catabolic process (GO:0009062)3.43417531
74pteridine-containing compound biosynthetic process (GO:0042559)3.42758597
75regulation of coenzyme metabolic process (GO:0051196)3.42681805
76regulation of cofactor metabolic process (GO:0051193)3.42681805
77chaperone-mediated protein transport (GO:0072321)3.41957625
78nucleobase biosynthetic process (GO:0046112)3.40573015
79DNA ligation (GO:0006266)3.40562165
80maturation of 5.8S rRNA (GO:0000460)3.40405923
81signal transduction involved in DNA damage checkpoint (GO:0072422)3.37544140
82signal transduction involved in DNA integrity checkpoint (GO:0072401)3.37544140
83cellular ketone body metabolic process (GO:0046950)3.34519730
84positive regulation of ligase activity (GO:0051351)3.33411906
85rRNA modification (GO:0000154)3.32767426
86signal transduction involved in cell cycle checkpoint (GO:0072395)3.32067803
87DNA strand elongation (GO:0022616)3.31521172
88IMP metabolic process (GO:0046040)3.31361181
89short-chain fatty acid metabolic process (GO:0046459)3.31249723
90aldehyde catabolic process (GO:0046185)3.29933207
91fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.27285342
92fatty acid transmembrane transport (GO:1902001)3.24971648
93regulation of ubiquitin-protein transferase activity (GO:0051438)3.24005641
94carnitine shuttle (GO:0006853)3.22297904
95DNA catabolic process, exonucleolytic (GO:0000738)3.21587077
96protein neddylation (GO:0045116)3.20716397
97amino-acid betaine metabolic process (GO:0006577)3.20375987
98NAD metabolic process (GO:0019674)3.18589811
99quinone biosynthetic process (GO:1901663)3.18476058
100ubiquinone biosynthetic process (GO:0006744)3.18476058
101water-soluble vitamin biosynthetic process (GO:0042364)3.16606495
102DNA replication-independent nucleosome assembly (GO:0006336)3.16562302
103DNA replication-independent nucleosome organization (GO:0034724)3.16562302
104metaphase plate congression (GO:0051310)3.16400046
105aromatic amino acid family catabolic process (GO:0009074)3.15708527
106non-recombinational repair (GO:0000726)3.14907054
107double-strand break repair via nonhomologous end joining (GO:0006303)3.14907054
108cytochrome complex assembly (GO:0017004)3.14573323
109regulation of ligase activity (GO:0051340)3.14134372
110protein localization to kinetochore (GO:0034501)3.14054436
111carnitine metabolic process (GO:0009437)3.12997904
112termination of RNA polymerase III transcription (GO:0006386)3.12619689
113transcription elongation from RNA polymerase III promoter (GO:0006385)3.12619689
114regulation of mitotic spindle checkpoint (GO:1903504)3.12501041
115regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.12501041
116alpha-linolenic acid metabolic process (GO:0036109)3.11254599
117folic acid-containing compound biosynthetic process (GO:0009396)3.10921575
118kynurenine metabolic process (GO:0070189)3.09287646
119monocarboxylic acid catabolic process (GO:0072329)3.08005622
120mitochondrial respiratory chain complex assembly (GO:0033108)3.06559204
121DNA damage response, detection of DNA damage (GO:0042769)3.05363532
122regulation of sequestering of triglyceride (GO:0010889)3.05231604
123negative regulation of DNA-dependent DNA replication (GO:2000104)2.99465785
124regulation of helicase activity (GO:0051095)2.99135167
125rRNA methylation (GO:0031167)2.97977116
126heart process (GO:0003015)2.97865631
127heart contraction (GO:0060047)2.97865631
128spindle checkpoint (GO:0031577)2.97563806
129sulfur amino acid catabolic process (GO:0000098)2.96617156
130exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.96127953
131biotin metabolic process (GO:0006768)2.95860624
132telomere maintenance via recombination (GO:0000722)2.94585564
133cellular respiration (GO:0045333)2.93150418
134DNA replication-dependent nucleosome organization (GO:0034723)2.93012082
135DNA replication-dependent nucleosome assembly (GO:0006335)2.93012082
136nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.92358720
137protein targeting to mitochondrion (GO:0006626)2.91196737
138cell cycle G1/S phase transition (GO:0044843)2.90925401
139G1/S transition of mitotic cell cycle (GO:0000082)2.90925401
140serine family amino acid biosynthetic process (GO:0009070)2.90375328
141aspartate family amino acid metabolic process (GO:0009066)2.89981133
142mitotic recombination (GO:0006312)2.89895342
143mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.89718907
144mitochondrial respiratory chain complex I assembly (GO:0032981)2.89718907
145NADH dehydrogenase complex assembly (GO:0010257)2.89718907
146dicarboxylic acid metabolic process (GO:0043648)2.89240431
147amino acid activation (GO:0043038)2.89065054
148tRNA aminoacylation (GO:0043039)2.89065054
149alpha-amino acid catabolic process (GO:1901606)2.88694199
150glycine metabolic process (GO:0006544)2.88684290
151mitotic spindle checkpoint (GO:0071174)2.88556703
152somatic hypermutation of immunoglobulin genes (GO:0016446)2.88252594
153somatic diversification of immune receptors via somatic mutation (GO:0002566)2.88252594
154tRNA aminoacylation for protein translation (GO:0006418)2.87755393
155ketone body metabolic process (GO:1902224)2.87657776
156serine family amino acid metabolic process (GO:0009069)2.87127841
157replication fork processing (GO:0031297)2.86929914
158pseudouridine synthesis (GO:0001522)2.86684319
159proteasome assembly (GO:0043248)2.86201980
160tryptophan catabolic process (GO:0006569)2.85708395
161indole-containing compound catabolic process (GO:0042436)2.85708395
162indolalkylamine catabolic process (GO:0046218)2.85708395
163regulation of cellular amine metabolic process (GO:0033238)2.82861210
164response to mercury ion (GO:0046689)2.82632139
165mitochondrial RNA metabolic process (GO:0000959)2.82318477
166carboxylic acid catabolic process (GO:0046395)2.81032771
167organic acid catabolic process (GO:0016054)2.81032771
168cofactor biosynthetic process (GO:0051188)2.78756854
169regulation of triglyceride catabolic process (GO:0010896)2.78262706
170ATP biosynthetic process (GO:0006754)2.78242232
171cellular amino acid catabolic process (GO:0009063)2.77843721
172regulation of sulfur metabolic process (GO:0042762)2.77503908
173ubiquinone metabolic process (GO:0006743)2.77304000
174bile acid biosynthetic process (GO:0006699)2.73650638
175triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.73228455
176protein complex biogenesis (GO:0070271)2.71813067
177amino acid salvage (GO:0043102)2.71510030
178L-methionine salvage (GO:0071267)2.71510030
179L-methionine biosynthetic process (GO:0071265)2.71510030
180oxidoreduction coenzyme metabolic process (GO:0006733)2.71065524
181AMP metabolic process (GO:0046033)2.70407216
182nicotinamide nucleotide metabolic process (GO:0046496)2.69505905
183pyridine nucleotide metabolic process (GO:0019362)2.69505905
184cofactor catabolic process (GO:0051187)2.68925964
185tryptophan metabolic process (GO:0006568)2.68559129
186regulation of mitochondrial translation (GO:0070129)2.67786487

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.58603085
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.36147075
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.45860195
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.52425163
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.24261770
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.05077158
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.94378036
8* MYC_18555785_ChIP-Seq_MESCs_Mouse2.92887449
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.90593730
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.87771956
11GATA1_22025678_ChIP-Seq_K562_Human2.87263793
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.82342371
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.72027710
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.71992412
15E2F7_22180533_ChIP-Seq_HELA_Human2.66431569
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.62047670
17EGR1_23403033_ChIP-Seq_LIVER_Mouse2.56198367
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.44995501
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.43583621
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.40981421
21* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.36178790
22CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.31567351
23LXR_22158963_ChIP-Seq_LIVER_Mouse2.20331601
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.19164024
25* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.17939117
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.12654888
27HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.02821878
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96052977
29FOXM1_23109430_ChIP-Seq_U2OS_Human1.91342020
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.90192793
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.88314160
32DCP1A_22483619_ChIP-Seq_HELA_Human1.86146340
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.85492979
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.85149810
35VDR_23849224_ChIP-Seq_CD4+_Human1.80959534
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79636993
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75987681
38* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75043643
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.65636986
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63602016
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62597402
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61934319
43GABP_19822575_ChIP-Seq_HepG2_Human1.61569691
44FOXP3_21729870_ChIP-Seq_TREG_Human1.61258237
45XRN2_22483619_ChIP-Seq_HELA_Human1.55868511
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55061308
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54911181
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51413487
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49459119
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.48886387
51MYC_18940864_ChIP-ChIP_HL60_Human1.47146148
52EWS_26573619_Chip-Seq_HEK293_Human1.46821060
53* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46093214
54BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.45933092
55FUS_26573619_Chip-Seq_HEK293_Human1.45679490
56CLOCK_20551151_ChIP-Seq_293T_Human1.45042367
57VDR_22108803_ChIP-Seq_LS180_Human1.40435279
58MYC_19079543_ChIP-ChIP_MESCs_Mouse1.40389438
59AR_21909140_ChIP-Seq_LNCAP_Human1.40085458
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39115240
61ZNF274_21170338_ChIP-Seq_K562_Hela1.37433008
62PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.36392407
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.33724704
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.32851861
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31793163
66* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.30739888
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29892136
68ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.27631414
69E2F4_17652178_ChIP-ChIP_JURKAT_Human1.26683871
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.25557202
71MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25199875
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24038797
73ELK1_19687146_ChIP-ChIP_HELA_Human1.23353840
74CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23302876
75NANOG_16153702_ChIP-ChIP_HESCs_Human1.22293128
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18326406
77GATA4_21415370_ChIP-Seq_HL-1_Mouse1.14872912
78* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14110648
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13060265
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12646837
81NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12200576
82SOX17_20123909_ChIP-Seq_XEN_Mouse1.07546490
83SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06476311
84E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.04612609
85MYCN_18555785_ChIP-Seq_MESCs_Mouse1.04158469
86FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.03959271
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03461746
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03223608
89IRF8_22096565_ChIP-ChIP_GC-B_Human1.02736936
90POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02280098
91* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02240339
92ZNF263_19887448_ChIP-Seq_K562_Human1.01908453
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01617370
94NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01138573
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.00946775
96NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.00539965
97TTF2_22483619_ChIP-Seq_HELA_Human0.99819984
98ELK1_22589737_ChIP-Seq_MCF10A_Human0.99793934
99PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99589326
100CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97884325
101TBX5_21415370_ChIP-Seq_HL-1_Mouse0.97241952
102RARG_19884340_ChIP-ChIP_MEFs_Mouse0.96040423
103KDM5A_27292631_Chip-Seq_BREAST_Human0.94696446
104POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94043311
105SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92865346
106HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92236903
107NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91906227
108* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91270837
109TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.90853235
110P300_19829295_ChIP-Seq_ESCs_Human0.89403326
111TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88719575
112PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88629526
113TFEB_21752829_ChIP-Seq_HELA_Human0.87995412
114TAF15_26573619_Chip-Seq_HEK293_Human0.87061518
115RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.86557605
116SOX2_16153702_ChIP-ChIP_HESCs_Human0.85798052
117ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.84141974
118DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84061446
119IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.83743623
120IGF1R_20145208_ChIP-Seq_DFB_Human0.82780717
121NANOG_18555785_ChIP-Seq_MESCs_Mouse0.82460123
122HTT_18923047_ChIP-ChIP_STHdh_Human0.82188392
123* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.81691056
124TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80841546
125NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.80663707
126CIITA_25753668_ChIP-Seq_RAJI_Human0.79924729
127E2F1_21310950_ChIP-Seq_MCF-7_Human0.79603022
128SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.79251132
129* GATA1_19941827_ChIP-Seq_MEL_Mouse0.79046943
130SOX2_18555785_ChIP-Seq_MESCs_Mouse0.77607453
131NOTCH1_21737748_ChIP-Seq_TLL_Human0.77071729
132RBPJ_22232070_ChIP-Seq_NCS_Mouse0.76572723
133GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76535393
134ZFP57_27257070_Chip-Seq_ESCs_Mouse0.75661169
135POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.75235033
136EOMES_21245162_ChIP-Seq_HESCs_Human0.74621131
137EZH2_27294783_Chip-Seq_NPCs_Mouse0.73048955
138E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.73003932
139HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.71930849

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.31499586
2MP0002139_abnormal_hepatobiliary_system4.27402254
3MP0003806_abnormal_nucleotide_metabolis4.25243018
4MP0008058_abnormal_DNA_repair4.04101097
5MP0005360_urolithiasis4.02679974
6MP0004147_increased_porphyrin_level3.83189664
7MP0003656_abnormal_erythrocyte_physiolo3.47498216
8MP0005085_abnormal_gallbladder_physiolo3.40300139
9MP0006036_abnormal_mitochondrial_physio3.35955445
10MP0002837_dystrophic_cardiac_calcinosis3.26502454
11MP0003111_abnormal_nucleus_morphology3.17512317
12MP0005365_abnormal_bile_salt3.11363177
13MP0003646_muscle_fatigue3.06727221
14MP0008875_abnormal_xenobiotic_pharmacok2.79362948
15MP0008057_abnormal_DNA_replication2.76542765
16MP0003941_abnormal_skin_development2.68121975
17MP0003718_maternal_effect2.67790968
18MP0003186_abnormal_redox_activity2.65229302
19MP0003077_abnormal_cell_cycle2.63467068
20MP0008007_abnormal_cellular_replicative2.52699934
21MP0004084_abnormal_cardiac_muscle2.49944657
22MP0008932_abnormal_embryonic_tissue2.48358608
23MP0003195_calcinosis2.46342080
24MP0005332_abnormal_amino_acid2.37997025
25MP0003786_premature_aging2.34466399
26MP0004215_abnormal_myocardial_fiber2.33443306
27MP0000749_muscle_degeneration2.32927166
28MP0010329_abnormal_lipoprotein_level2.12243649
29MP0005330_cardiomyopathy2.11815384
30MP0004036_abnormal_muscle_relaxation2.05830010
31MP0004130_abnormal_muscle_cell2.01247922
32MP0008877_abnormal_DNA_methylation1.98588049
33MP0006035_abnormal_mitochondrial_morpho1.97498450
34MP0001764_abnormal_homeostasis1.96509810
35MP0005319_abnormal_enzyme/_coenzyme1.96243013
36MP0002938_white_spotting1.83193462
37MP0005584_abnormal_enzyme/coenzyme_acti1.81445279
38MP0009840_abnormal_foam_cell1.78285990
39MP0005636_abnormal_mineral_homeostasis1.77387738
40MP0000751_myopathy1.76832895
41MP0000372_irregular_coat_pigmentation1.74138000
42MP0005083_abnormal_biliary_tract1.73390019
43MP0008775_abnormal_heart_ventricle1.72297331
44MP0002102_abnormal_ear_morphology1.70399234
45MP0006072_abnormal_retinal_apoptosis1.67138892
46MP0005670_abnormal_white_adipose1.66116227
47MP0003890_abnormal_embryonic-extraembry1.63233815
48MP0009643_abnormal_urine_homeostasis1.62285188
49MP0000609_abnormal_liver_physiology1.58127914
50MP0003221_abnormal_cardiomyocyte_apopto1.55710987
51MP0004043_abnormal_pH_regulation1.54942006
52MP0001529_abnormal_vocalization1.54922397
53MP0002269_muscular_atrophy1.54070801
54MP0006054_spinal_hemorrhage1.50173442
55MP0003252_abnormal_bile_duct1.49274468
56MP0003191_abnormal_cellular_cholesterol1.46264025
57MP0002118_abnormal_lipid_homeostasis1.45780133
58MP0001293_anophthalmia1.42199031
59MP0001730_embryonic_growth_arrest1.39647743
60MP0005266_abnormal_metabolism1.39184411
61MP0002090_abnormal_vision1.38532142
62MP0001544_abnormal_cardiovascular_syste1.35782161
63MP0005385_cardiovascular_system_phenoty1.35782161
64MP0002972_abnormal_cardiac_muscle1.35200419
65MP0004087_abnormal_muscle_fiber1.34151203
66MP0000750_abnormal_muscle_regeneration1.29550198
67MP0009697_abnormal_copulation1.26216770
68MP0001666_abnormal_nutrient_absorption1.24455547
69MP0005620_abnormal_muscle_contractility1.22634393
70MP0005379_endocrine/exocrine_gland_phen1.20220265
71MP0001697_abnormal_embryo_size1.20206217
72MP0000747_muscle_weakness1.20139843
73MP0002876_abnormal_thyroid_physiology1.20079738
74MP0001756_abnormal_urination1.17948981
75MP0000516_abnormal_urinary_system1.17700142
76MP0005367_renal/urinary_system_phenotyp1.17700142
77MP0003011_delayed_dark_adaptation1.15994749
78MP0003121_genomic_imprinting1.15181246
79MP0002332_abnormal_exercise_endurance1.14645396
80MP0005408_hypopigmentation1.13578563
81MP0001853_heart_inflammation1.11929182
82MP0002138_abnormal_hepatobiliary_system1.11601855
83MP0000343_altered_response_to1.11396377
84MP0005376_homeostasis/metabolism_phenot1.11177508
85MP0000350_abnormal_cell_proliferation1.10057093
86MP0010352_gastrointestinal_tract_polyps1.08955490
87MP0005666_abnormal_adipose_tissue1.08693774
88MP0010307_abnormal_tumor_latency1.07574639
89MP0000598_abnormal_liver_morphology1.06729162
90MP0002106_abnormal_muscle_physiology1.05961672
91MP0009672_abnormal_birth_weight1.05688638
92MP0001984_abnormal_olfaction1.05273172
93MP0006138_congestive_heart_failure1.04405008
94MP0002163_abnormal_gland_morphology1.04149378
95MP0001672_abnormal_embryogenesis/_devel1.03158812
96MP0005380_embryogenesis_phenotype1.03158812
97MP0002971_abnormal_brown_adipose1.02842240
98MP0003937_abnormal_limbs/digits/tail_de1.01433432
99MP0002084_abnormal_developmental_patter0.99270606
100MP0008469_abnormal_protein_level0.98982822
101MP0000230_abnormal_systemic_arterial0.98610561
102MP0003123_paternal_imprinting0.98391490
103MP0005535_abnormal_body_temperature0.97811807
104MP0002160_abnormal_reproductive_system0.97268202
105MP0005395_other_phenotype0.97000062
106MP0001929_abnormal_gametogenesis0.96831847
107MP0004019_abnormal_vitamin_homeostasis0.96619665
108MP0002078_abnormal_glucose_homeostasis0.96571967
109MP0002254_reproductive_system_inflammat0.96115470
110MP0010630_abnormal_cardiac_muscle0.96077651
111MP0005253_abnormal_eye_physiology0.95357633
112MP0005075_abnormal_melanosome_morpholog0.95144876
113MP0006292_abnormal_olfactory_placode0.93623833
114MP0010234_abnormal_vibrissa_follicle0.92302865
115MP0002080_prenatal_lethality0.90404597
116MP0000759_abnormal_skeletal_muscle0.89434100
117MP0002085_abnormal_embryonic_tissue0.87911506
118MP0008995_early_reproductive_senescence0.87311066
119MP0003122_maternal_imprinting0.86925068
120MP0008789_abnormal_olfactory_epithelium0.86705091
121MP0002210_abnormal_sex_determination0.86053152
122MP0005220_abnormal_exocrine_pancreas0.85688953
123MP0003693_abnormal_embryo_hatching0.85450378
124MP0000653_abnormal_sex_gland0.85260134
125MP0003984_embryonic_growth_retardation0.83067390
126MP0004957_abnormal_blastocyst_morpholog0.82990930
127MP0002088_abnormal_embryonic_growth/wei0.82148840
128MP0002233_abnormal_nose_morphology0.81894482
129MP0005334_abnormal_fat_pad0.81447278
130MP0001145_abnormal_male_reproductive0.81294745
131MP0009763_increased_sensitivity_to0.80924093
132MP0000358_abnormal_cell_content/0.79540894
133MP0009642_abnormal_blood_homeostasis0.78593894
134MP0002396_abnormal_hematopoietic_system0.78588525
135MP0009764_decreased_sensitivity_to0.78502563
136MP0000313_abnormal_cell_death0.77820581
137MP0000647_abnormal_sebaceous_gland0.76650423
138MP0004233_abnormal_muscle_weight0.76491058
139MP0005369_muscle_phenotype0.76334946
140MP0004484_altered_response_of0.74522990
141MP0004133_heterotaxia0.73602871
142MP0003315_abnormal_perineum_morphology0.73442347
143MP0003137_abnormal_impulse_conducting0.73324431
144MP0002970_abnormal_white_adipose0.73302802
145MP0003119_abnormal_digestive_system0.73260740
146MP0005084_abnormal_gallbladder_morpholo0.72827141
147MP0005165_increased_susceptibility_to0.71894466
148MP0003724_increased_susceptibility_to0.71342581
149MP0005551_abnormal_eye_electrophysiolog0.70647405
150MP0001286_abnormal_eye_development0.70615803
151MP0005058_abnormal_lysosome_morphology0.70509043
152MP0001119_abnormal_female_reproductive0.70487325
153MP0002736_abnormal_nociception_after0.69960205
154MP0009780_abnormal_chondrocyte_physiolo0.69590530
155MP0002751_abnormal_autonomic_nervous0.69362355
156MP0005397_hematopoietic_system_phenotyp0.66194153
157MP0001545_abnormal_hematopoietic_system0.66194153
158MP0002136_abnormal_kidney_physiology0.65572928
159MP0001765_abnormal_ion_homeostasis0.65423769
160MP0001661_extended_life_span0.64863225
161MP0008872_abnormal_physiological_respon0.64689208
162MP0003567_abnormal_fetal_cardiomyocyte0.62882260
163MP0002132_abnormal_respiratory_system0.61943872
164MP0009115_abnormal_fat_cell0.61288241
165MP0009785_altered_susceptibility_to0.59743622
166MP0005647_abnormal_sex_gland0.58245998
167MP0004085_abnormal_heartbeat0.57525992
168MP0009333_abnormal_splenocyte_physiolog0.56682090
169MP0005451_abnormal_body_composition0.55643514

Predicted human phenotypes

RankGene SetZ-score
1Hepatic necrosis (HP:0002605)4.67968599
2Abnormality of the heme biosynthetic pathway (HP:0010472)4.47116568
3Abnormal mitochondria in muscle tissue (HP:0008316)4.19461537
4Hepatocellular necrosis (HP:0001404)4.14897048
5Abnormality of fatty-acid metabolism (HP:0004359)4.12524632
6Hypoglycemic coma (HP:0001325)4.11012391
7Acute necrotizing encephalopathy (HP:0006965)4.06921402
8Acute encephalopathy (HP:0006846)4.05453019
9Myoglobinuria (HP:0002913)3.95987033
10Cerebral edema (HP:0002181)3.86380943
11Increased CSF lactate (HP:0002490)3.77436080
12Mitochondrial inheritance (HP:0001427)3.76127410
13Abnormality of glycolysis (HP:0004366)3.72074842
14Increased serum pyruvate (HP:0003542)3.72074842
15Dicarboxylic aciduria (HP:0003215)3.59745718
16Abnormality of dicarboxylic acid metabolism (HP:0010995)3.59745718
17Generalized aminoaciduria (HP:0002909)3.59520547
18Hyperammonemia (HP:0001987)3.59332572
19Rhabdomyolysis (HP:0003201)3.58519580
20Hyperglycinuria (HP:0003108)3.57298662
21Increased muscle lipid content (HP:0009058)3.53979859
22Nausea (HP:0002018)3.48817681
23Ketosis (HP:0001946)3.45164536
24Ketoacidosis (HP:0001993)3.43713406
25Lactic acidosis (HP:0003128)3.41272251
26Progressive macrocephaly (HP:0004481)3.32305493
27Methylmalonic acidemia (HP:0002912)3.31885146
28Decreased activity of mitochondrial respiratory chain (HP:0008972)3.29536476
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.29536476
30Abnormality of serine family amino acid metabolism (HP:0010894)3.25284663
31Abnormality of glycine metabolism (HP:0010895)3.25284663
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.23398032
33Exercise-induced muscle cramps (HP:0003710)3.19394636
34Increased intramyocellular lipid droplets (HP:0012240)3.18518329
35Lethargy (HP:0001254)3.12531084
36Increased serum lactate (HP:0002151)3.10831553
37Abnormality of the labia minora (HP:0012880)3.07431156
38Abnormality of alanine metabolism (HP:0010916)3.07331798
39Hyperalaninemia (HP:0003348)3.07331798
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.07331798
41Abnormality of aromatic amino acid family metabolism (HP:0004338)3.02611721
42Cholelithiasis (HP:0001081)3.01980226
43Palpitations (HP:0001962)3.01260689
44Metabolic acidosis (HP:0001942)2.94138658
45Hyperbilirubinemia (HP:0002904)2.91580340
46Hypobetalipoproteinemia (HP:0003563)2.90732524
47Hyperglycinemia (HP:0002154)2.88596955
48Lipid accumulation in hepatocytes (HP:0006561)2.86780511
49Abnormal gallbladder morphology (HP:0012437)2.83448373
50Ragged-red muscle fibers (HP:0003200)2.81730628
51Respiratory failure (HP:0002878)2.76064887
52Exercise intolerance (HP:0003546)2.75565647
53Hyperinsulinemic hypoglycemia (HP:0000825)2.72827595
54Meckel diverticulum (HP:0002245)2.72654149
55Pancreatic islet-cell hyperplasia (HP:0004510)2.67289338
56Vomiting (HP:0002013)2.66248234
57Proximal tubulopathy (HP:0000114)2.65940231
58Renal Fanconi syndrome (HP:0001994)2.65876894
59Abnormality of serum amino acid levels (HP:0003112)2.65715107
60Colon cancer (HP:0003003)2.62859427
61Chromosomal breakage induced by crosslinking agents (HP:0003221)2.62573507
62Exercise-induced myalgia (HP:0003738)2.62473065
63Abnormality of chromosome stability (HP:0003220)2.62413239
64CNS demyelination (HP:0007305)2.61306815
65Poikilocytosis (HP:0004447)2.61206375
66Abnormality of the ileum (HP:0001549)2.58408700
67Type I transferrin isoform profile (HP:0003642)2.54172966
68Conjunctival hamartoma (HP:0100780)2.54171740
69Abnormality of urine glucose concentration (HP:0011016)2.51192463
70Glycosuria (HP:0003076)2.51192463
71Intrahepatic cholestasis (HP:0001406)2.50424812
72Gout (HP:0001997)2.49812226
73Chromsome breakage (HP:0040012)2.49067413
74Xanthomatosis (HP:0000991)2.48769033
75Hypoglycemic seizures (HP:0002173)2.45669718
76Megaloblastic anemia (HP:0001889)2.44739201
77Abnormality of the anterior horn cell (HP:0006802)2.42542121
78Degeneration of anterior horn cells (HP:0002398)2.42542121
79Increased hepatocellular lipid droplets (HP:0006565)2.41082604
80Abnormality of vitamin B metabolism (HP:0004340)2.40730302
81Abnormality of the preputium (HP:0100587)2.38725103
82Abnormality of monocarboxylic acid metabolism (HP:0010996)2.37298086
83Aplasia/Hypoplasia of the uvula (HP:0010293)2.35964729
84Cholecystitis (HP:0001082)2.32319037
85Abnormal gallbladder physiology (HP:0012438)2.32319037
86Reticulocytosis (HP:0001923)2.31647214
87Hypolipoproteinemia (HP:0010981)2.30930875
88Abnormal lung lobation (HP:0002101)2.30393625
89Microvesicular hepatic steatosis (HP:0001414)2.29809842
90Esophageal neoplasm (HP:0100751)2.27594368
91Neoplasm of head and neck (HP:0012288)2.27594368
92Multiple enchondromatosis (HP:0005701)2.26035707
93Neuroendocrine neoplasm (HP:0100634)2.26027425
94Ependymoma (HP:0002888)2.25008210
95Abnormality of aspartate family amino acid metabolism (HP:0010899)2.23542468
963-Methylglutaconic aciduria (HP:0003535)2.23203523
97Abnormality of the vitamin B12 metabolism (HP:0004341)2.18439794
98Reduced antithrombin III activity (HP:0001976)2.17065157
99Abnormality of purine metabolism (HP:0004352)2.16615081
100Leukodystrophy (HP:0002415)2.16454127
101Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.16224664
102Abnormal number of erythroid precursors (HP:0012131)2.15746673
103Pheochromocytoma (HP:0002666)2.15671963
104Calf muscle hypertrophy (HP:0008981)2.14568479
105Methylmalonic aciduria (HP:0012120)2.13416004
106Acanthocytosis (HP:0001927)2.13017212
107Deep venous thrombosis (HP:0002625)2.12943207
108Sudden death (HP:0001699)2.12189497
109Lipoatrophy (HP:0100578)2.11799423
110Renal cortical cysts (HP:0000803)2.10562308
111Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.10315359
112Hyperlipoproteinemia (HP:0010980)2.09607058
113Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.06217187
114Abnormal protein N-linked glycosylation (HP:0012347)2.06217187
115Abnormal protein glycosylation (HP:0012346)2.06217187
116Abnormal glycosylation (HP:0012345)2.06217187
117Abnormality of glutamine family amino acid metabolism (HP:0010902)2.05145076
118Ventricular tachycardia (HP:0004756)2.04765277
119Prolonged partial thromboplastin time (HP:0003645)2.04601323
120Neoplasm of the adrenal gland (HP:0100631)2.04353926
121Hypothermia (HP:0002045)2.04132475
122Abnormality of the gallbladder (HP:0005264)2.04034150
123Birth length less than 3rd percentile (HP:0003561)2.03521543
124Increased serum ferritin (HP:0003281)2.03232739
125Exertional dyspnea (HP:0002875)2.03027906
126Small intestinal stenosis (HP:0012848)2.02607615
127Duodenal stenosis (HP:0100867)2.02607615
128Abnormality of nucleobase metabolism (HP:0010932)2.00341269
129Dilated cardiomyopathy (HP:0001644)2.00167634
130Hyperuricemia (HP:0002149)1.99822262
131Increased purine levels (HP:0004368)1.99822262
132Rhabdomyosarcoma (HP:0002859)1.97945849
133Abnormality of the duodenum (HP:0002246)1.97777752
134Symptomatic seizures (HP:0011145)1.97123150
135Abnormality of methionine metabolism (HP:0010901)1.96679052
136Abnormality of cells of the erythroid lineage (HP:0012130)1.95623024
137Muscle hypertrophy of the lower extremities (HP:0008968)1.95130245
138Hypoalphalipoproteinemia (HP:0003233)1.94888974
139Abnormality of the pancreatic islet cells (HP:0006476)1.87306793
140Abnormality of endocrine pancreas physiology (HP:0012093)1.87306793
141Abnormality of sulfur amino acid metabolism (HP:0004339)1.84911302
142Abnormality of vitamin metabolism (HP:0100508)1.84262049
143Optic disc pallor (HP:0000543)1.84135494
144Respiratory difficulties (HP:0002880)1.82524638
145Intestinal atresia (HP:0011100)1.81466577
146Bifid tongue (HP:0010297)1.76438566
147Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.75948803
148Ovarian neoplasm (HP:0100615)1.75907792
149Posterior subcapsular cataract (HP:0007787)1.74996550

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.35329283
2EIF2AK14.03330656
3PDK43.51278285
4PDK33.51278285
5NME23.32688076
6NEK13.29079673
7VRK23.00190768
8TRIM282.82234095
9OBSCN2.71572711
10MYLK2.57187787
11TTK2.55435437
12PLK32.42953270
13SRPK12.33448418
14MKNK22.23567198
15FLT32.21457526
16TTN2.12207341
17PINK12.10236202
18PDK22.08419357
19EIF2AK32.07760729
20STK162.07265140
21BUB12.00672884
22PKN21.97439065
23MKNK11.96500570
24PLK41.91868149
25NUAK11.88806811
26WNK31.84558371
27NEK91.77357550
28BMPR1B1.72449916
29KDR1.72038251
30TRIB31.68633641
31NME11.62837594
32WEE11.62055697
33MAP2K31.53485199
34ERBB31.50740753
35SCYL21.43460280
36PLK11.41485231
37TNIK1.39599956
38TAF11.38956050
39ACVR1B1.38617361
40MAP4K21.38416797
41BRSK21.37622038
42LMTK21.36323297
43PIM21.34180595
44PHKG21.28859556
45PHKG11.28859556
46FRK1.28130212
47PIK3CG1.27615772
48ERN11.24817183
49STK241.15839391
50CSNK1G11.14577938
51MUSK1.14559022
52TIE11.13403525
53MAP3K111.10156711
54BCR1.09588485
55PLK21.07152834
56TSSK61.06508061
57LRRK21.04028587
58MAPKAPK30.97783448
59CSNK1G30.96537030
60ZAK0.95404363
61VRK10.94599982
62ABL20.93737562
63TYK20.92440554
64PAK40.92121337
65PIK3CA0.91724372
66OXSR10.89133260
67MAPK110.87523827
68ILK0.87266320
69PASK0.86808794
70MAP3K30.83449424
71ATR0.83422229
72GRK10.82952754
73STK390.80171052
74TGFBR10.80042611
75BRSK10.79828368
76TBK10.79597954
77CSNK1G20.79481557
78MST40.71713414
79STK30.69213959
80STK40.69030906
81WNK40.68139553
82CHEK20.66364367
83PNCK0.66233797
84CSNK1A1L0.65361593
85MAPK120.65198556
86CCNB10.64911793
87JAK30.64610794
88CDC70.61655051
89ATM0.60310216
90ALK0.59363535
91MAP3K120.59242150
92SIK10.58981527
93TRPM70.57469700
94TGFBR20.56193136
95STK38L0.55060712
96ERBB40.53686440
97LIMK10.53242443
98TESK10.52888631
99INSRR0.51986183
100JAK20.51607521
101MAP3K50.51358502
102ARAF0.50962503
103FGFR10.50949370
104MAP2K60.49945509
105ZAP700.47546537
106MAP4K10.47090147
107AURKB0.46723310
108KIT0.45772063
109CDK70.44103241
110FGFR20.44092913
111FGFR40.44064067
112CHEK10.43778795
113TAOK20.43172094
114GRK70.42222582
115PIM10.42071022
116TEC0.41940549
117EIF2AK20.41917010
118NLK0.41890921
119PRKCI0.41852385
120CSNK2A10.40043662
121PRKAA10.39632855
122DAPK30.38569255
123SIK30.37166217
124PBK0.36982127
125MAP3K80.36278446
126MAP2K10.36087400
127PRKCE0.35694447
128PRKACG0.35227358
129FER0.35206666
130PRKAA20.35119606
131PRKCG0.35088662
132RPS6KL10.34970226
133RPS6KC10.34970226
134STK100.34890151
135RPS6KA40.34748618
136RPS6KA60.34652428
137DYRK30.34243601
138IRAK30.33761933
139NEK20.33327033
140TESK20.33102635
141SYK0.32798312
142AURKA0.32615126
143CSNK1E0.32397528
144DAPK10.30845763
145TLK10.30713545
146RPS6KB20.30703749
147CDK40.30121292
148CSNK2A20.28755034
149DYRK20.27939237
150CAMKK20.26716630
151MAPKAPK50.26457709
152CDK30.25958145
153PAK30.25418405
154CSNK1A10.25080601
155PRKDC0.23320181
156CAMK2D0.23188866
157CDK80.23149359
158CDK10.23070659

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.38683194
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.50802456
3Propanoate metabolism_Homo sapiens_hsa006403.05447380
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.86452098
5Fatty acid degradation_Homo sapiens_hsa000712.82321147
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.77232992
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.76996666
8Carbon metabolism_Homo sapiens_hsa012002.44341551
9Pyruvate metabolism_Homo sapiens_hsa006202.41981812
10Oxidative phosphorylation_Homo sapiens_hsa001902.36492896
11Non-homologous end-joining_Homo sapiens_hsa034502.36482939
12Parkinsons disease_Homo sapiens_hsa050122.32722156
13Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.16148127
14Fatty acid metabolism_Homo sapiens_hsa012122.13395798
15Proteasome_Homo sapiens_hsa030502.09867764
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.83210134
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.81156070
18Biosynthesis of amino acids_Homo sapiens_hsa012301.80890619
19Peroxisome_Homo sapiens_hsa041461.76676645
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.74815012
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.72652995
22Tryptophan metabolism_Homo sapiens_hsa003801.72628842
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.70071293
24Butanoate metabolism_Homo sapiens_hsa006501.69577850
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.65378568
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.62350801
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.59354677
28Arginine biosynthesis_Homo sapiens_hsa002201.52440291
29Fanconi anemia pathway_Homo sapiens_hsa034601.51998668
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.51014656
31Fatty acid elongation_Homo sapiens_hsa000621.50822585
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.48528021
33beta-Alanine metabolism_Homo sapiens_hsa004101.47140646
34PPAR signaling pathway_Homo sapiens_hsa033201.46766659
35Basal transcription factors_Homo sapiens_hsa030221.42439161
36Alzheimers disease_Homo sapiens_hsa050101.39184330
37Huntingtons disease_Homo sapiens_hsa050161.36899918
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.31608727
39Steroid biosynthesis_Homo sapiens_hsa001001.28727565
40DNA replication_Homo sapiens_hsa030301.28371687
41Sulfur relay system_Homo sapiens_hsa041221.24877890
42Sulfur metabolism_Homo sapiens_hsa009201.24688412
43Ribosome_Homo sapiens_hsa030101.24483155
44Pentose phosphate pathway_Homo sapiens_hsa000301.23087219
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.22730262
46Folate biosynthesis_Homo sapiens_hsa007901.19741910
47Selenocompound metabolism_Homo sapiens_hsa004501.19601435
48Cell cycle_Homo sapiens_hsa041101.18951848
49Phenylalanine metabolism_Homo sapiens_hsa003601.12738643
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.12590586
51Caffeine metabolism_Homo sapiens_hsa002321.12499410
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07508945
53One carbon pool by folate_Homo sapiens_hsa006701.07459900
54Starch and sucrose metabolism_Homo sapiens_hsa005001.06849821
55Tyrosine metabolism_Homo sapiens_hsa003501.06395201
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01744161
57Glutathione metabolism_Homo sapiens_hsa004801.00175400
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98419592
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96460623
60Cardiac muscle contraction_Homo sapiens_hsa042600.96425556
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93957774
62Pyrimidine metabolism_Homo sapiens_hsa002400.93331919
63Vitamin B6 metabolism_Homo sapiens_hsa007500.92143552
64Arginine and proline metabolism_Homo sapiens_hsa003300.91510405
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.91483819
66Protein export_Homo sapiens_hsa030600.90911698
67Chemical carcinogenesis_Homo sapiens_hsa052040.88237446
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86454436
69Metabolic pathways_Homo sapiens_hsa011000.84488249
70Complement and coagulation cascades_Homo sapiens_hsa046100.82089072
71Histidine metabolism_Homo sapiens_hsa003400.81943084
72Galactose metabolism_Homo sapiens_hsa000520.81632676
73Fructose and mannose metabolism_Homo sapiens_hsa000510.79588669
74Nitrogen metabolism_Homo sapiens_hsa009100.77085094
75RNA polymerase_Homo sapiens_hsa030200.74651262
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.73149297
77Oocyte meiosis_Homo sapiens_hsa041140.68189217
78Mismatch repair_Homo sapiens_hsa034300.67616516
79Fat digestion and absorption_Homo sapiens_hsa049750.66765652
80Fatty acid biosynthesis_Homo sapiens_hsa000610.61992482
81Retinol metabolism_Homo sapiens_hsa008300.57397493
82Vitamin digestion and absorption_Homo sapiens_hsa049770.55390854
83N-Glycan biosynthesis_Homo sapiens_hsa005100.52466474
84Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.51993109
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51315724
86p53 signaling pathway_Homo sapiens_hsa041150.50838302
87Base excision repair_Homo sapiens_hsa034100.50670059
88Purine metabolism_Homo sapiens_hsa002300.47078662
89mRNA surveillance pathway_Homo sapiens_hsa030150.47030139
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46789155
91ABC transporters_Homo sapiens_hsa020100.43828490
92Nucleotide excision repair_Homo sapiens_hsa034200.42523498
93Glycerolipid metabolism_Homo sapiens_hsa005610.42208311
94Collecting duct acid secretion_Homo sapiens_hsa049660.42203860
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38752792
96Bile secretion_Homo sapiens_hsa049760.37453315
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.32739786
98RNA transport_Homo sapiens_hsa030130.28095809
99Phototransduction_Homo sapiens_hsa047440.26889228
100Staphylococcus aureus infection_Homo sapiens_hsa051500.26604905
101Legionellosis_Homo sapiens_hsa051340.25288915
102Regulation of autophagy_Homo sapiens_hsa041400.20036565
103Insulin resistance_Homo sapiens_hsa049310.17613971
104TGF-beta signaling pathway_Homo sapiens_hsa043500.17533579
105Homologous recombination_Homo sapiens_hsa034400.17077932
106RNA degradation_Homo sapiens_hsa030180.15830253
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.15165716
108Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.15156239
109Glucagon signaling pathway_Homo sapiens_hsa049220.14164793
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13161175
111Maturity onset diabetes of the young_Homo sapiens_hsa049500.13020666
112Spliceosome_Homo sapiens_hsa030400.13010386
113Vibrio cholerae infection_Homo sapiens_hsa051100.11938251
114Mineral absorption_Homo sapiens_hsa049780.11618398
115AMPK signaling pathway_Homo sapiens_hsa041520.11596147
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.11039238
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.10872629
118Systemic lupus erythematosus_Homo sapiens_hsa053220.09536911

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