PRDX3P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1monoubiquitinated protein deubiquitination (GO:0035520)5.19224727
2phenol-containing compound catabolic process (GO:0019336)5.07348964
3hormone catabolic process (GO:0042447)4.84057795
4regulation of B cell receptor signaling pathway (GO:0050855)4.15544273
5positive regulation of gamma-delta T cell activation (GO:0046645)4.08182528
6tolerance induction (GO:0002507)3.92442839
7protein K63-linked deubiquitination (GO:0070536)3.83599751
8positive regulation of granulocyte differentiation (GO:0030854)3.75306592
9energy homeostasis (GO:0097009)3.74047380
10cellular extravasation (GO:0045123)3.68393135
11regulation of RIG-I signaling pathway (GO:0039535)3.63158340
12regulation of B cell apoptotic process (GO:0002902)3.56033921
13protein K11-linked deubiquitination (GO:0035871)3.51882713
14negative regulation of B cell proliferation (GO:0030889)3.49949280
15thyroid hormone generation (GO:0006590)3.47210674
16positive regulation of B cell differentiation (GO:0045579)3.43294048
17positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.41112305
18dosage compensation (GO:0007549)3.37461512
19positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.28251279
20detection of molecule of bacterial origin (GO:0032490)3.27734530
21regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.24950762
22protein K48-linked deubiquitination (GO:0071108)3.23308863
23thyroid hormone metabolic process (GO:0042403)3.22208639
24neutrophil activation involved in immune response (GO:0002283)3.19305965
25positive regulation of mRNA catabolic process (GO:0061014)3.19139083
26negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.10402790
27negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.08792063
28negative regulation of T-helper cell differentiation (GO:0045623)3.08792063
29regulation of interleukin-8 biosynthetic process (GO:0045414)3.08632450
30neutrophil mediated immunity (GO:0002446)3.07782037
31B cell receptor signaling pathway (GO:0050853)2.95687474
32positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.95120697
33positive regulation of natural killer cell differentiation (GO:0032825)2.93964700
34regulation of regulatory T cell differentiation (GO:0045589)2.93270448
35histone mRNA catabolic process (GO:0071044)2.93211526
36rRNA catabolic process (GO:0016075)2.90160374
37regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.89673342
38negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.87542169
39negative regulation of B cell activation (GO:0050869)2.87052156
40neutrophil activation (GO:0042119)2.85125104
41regulation of oxidative stress-induced neuron death (GO:1903203)2.83804226
42response to peptidoglycan (GO:0032494)2.82344845
43regulation of gamma-delta T cell activation (GO:0046643)2.80320037
44regulation of mRNA catabolic process (GO:0061013)2.79266545
45microglial cell activation (GO:0001774)2.77753609
46iron ion import (GO:0097286)2.76968721
47negative regulation of translation, ncRNA-mediated (GO:0040033)2.75302561
48regulation of translation, ncRNA-mediated (GO:0045974)2.75302561
49negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.75302561
50production of molecular mediator involved in inflammatory response (GO:0002532)2.72786251
51myeloid leukocyte mediated immunity (GO:0002444)2.71227959
52negative regulation of interleukin-12 production (GO:0032695)2.70157296
53cell wall macromolecule metabolic process (GO:0044036)2.69919867
54phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.69514597
55regulation of interleukin-6 biosynthetic process (GO:0045408)2.69079435
56macrophage activation (GO:0042116)2.68838686
57JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.65961198
58adenosine metabolic process (GO:0046085)2.65243378
59regulation of gamma-delta T cell differentiation (GO:0045586)2.64912591
60hepatocyte apoptotic process (GO:0097284)2.64796579
61RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.62535925
62regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.61445878
63rRNA methylation (GO:0031167)2.60697802
64nuclear pore complex assembly (GO:0051292)2.60169943
65regulation of B cell differentiation (GO:0045577)2.57589514
66detection of other organism (GO:0098543)2.57058592
67defense response to protozoan (GO:0042832)2.57050040
68positive regulation of toll-like receptor signaling pathway (GO:0034123)2.55943716
69mast cell activation (GO:0045576)2.55465924
70positive T cell selection (GO:0043368)2.55448135
71positive regulation by symbiont of host defense response (GO:0052509)2.54931544
72modulation by symbiont of host defense response (GO:0052031)2.54931544
73modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.54931544
74modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.54931544
75positive regulation by organism of defense response of other organism involved in symbiotic interact2.54931544
76modulation by symbiont of host immune response (GO:0052553)2.54931544
77regulation of alpha-beta T cell proliferation (GO:0046640)2.54871426
78granulocyte activation (GO:0036230)2.54222051
79regulation of interferon-alpha production (GO:0032647)2.54178603
80maturation of 5.8S rRNA (GO:0000460)2.51916047
81positive regulation of interferon-alpha production (GO:0032727)2.51014368
82regulation of memory T cell differentiation (GO:0043380)2.50152754
83regulation of interleukin-12 biosynthetic process (GO:0045075)2.49859659
84positive regulation of interleukin-1 beta secretion (GO:0050718)2.48519214
85interferon-gamma production (GO:0032609)2.48159794
86cell wall macromolecule catabolic process (GO:0016998)2.47465308
87detection of external biotic stimulus (GO:0098581)2.47048283
88detection of biotic stimulus (GO:0009595)2.45681996
89regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.45617299
90positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.45252003
91regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.45252003
92positive regulation of interferon-beta production (GO:0032728)2.44860313
93definitive hemopoiesis (GO:0060216)2.44397019
94activated T cell proliferation (GO:0050798)2.44378563
95I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.41734010
96positive regulation of mRNA metabolic process (GO:1903313)2.40562968
97B cell homeostasis (GO:0001782)2.39348434
98response to protozoan (GO:0001562)2.39180404
99leukocyte degranulation (GO:0043299)2.38526440
100myeloid cell activation involved in immune response (GO:0002275)2.38179469

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.65050202
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.71265169
3STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.39583202
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.20291347
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.06318628
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.98387577
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.63666287
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.40240956
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.34411751
10VDR_22108803_ChIP-Seq_LS180_Human2.31959409
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.25145632
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.24657259
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.22659963
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.19683645
15MYB_26560356_Chip-Seq_TH2_Human2.04992841
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.03892751
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.01701830
18SMAD_19615063_ChIP-ChIP_OVARY_Human1.96300975
19VDR_23849224_ChIP-Seq_CD4+_Human1.94487551
20ELF1_17652178_ChIP-ChIP_JURKAT_Human1.87220716
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.84843721
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84706415
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.81523209
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.76064007
25IRF8_27001747_Chip-Seq_BMDM_Mouse1.75477224
26EWS_26573619_Chip-Seq_HEK293_Human1.74065049
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.72435833
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.69999576
29ER_23166858_ChIP-Seq_MCF-7_Human1.67259746
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66873064
31ZNF274_21170338_ChIP-Seq_K562_Hela1.66466489
32SPI1_23547873_ChIP-Seq_NB4_Human1.65850133
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65377560
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.63882156
35RUNX_20019798_ChIP-Seq_JUKART_Human1.62045633
36ELK1_19687146_ChIP-ChIP_HELA_Human1.58043794
37GATA3_26560356_Chip-Seq_TH2_Human1.54911919
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.54213153
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54178290
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53038624
41IGF1R_20145208_ChIP-Seq_DFB_Human1.52822916
42EST1_17652178_ChIP-ChIP_JURKAT_Human1.51544829
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49699983
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48664499
45GATA3_27048872_Chip-Seq_THYMUS_Human1.48565219
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48508200
47FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.47571497
48MYB_26560356_Chip-Seq_TH1_Human1.46920000
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.42488695
50STAT4_19710469_ChIP-ChIP_TH1__Mouse1.41319492
51FOXP3_21729870_ChIP-Seq_TREG_Human1.40762577
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.39644674
53E2F7_22180533_ChIP-Seq_HELA_Human1.39445150
54CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.38597750
55GABP_17652178_ChIP-ChIP_JURKAT_Human1.37690463
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35516079
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33753561
58VDR_24787735_ChIP-Seq_THP-1_Human1.32473587
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31625789
60EGR1_23403033_ChIP-Seq_LIVER_Mouse1.31043793
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24403058
62RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.24112432
63PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19937629
64SALL4_22934838_ChIP-ChIP_CD34+_Human1.18671427
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18130151
66KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.15735472
67GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15702557
68GATA1_22025678_ChIP-Seq_K562_Human1.13759239
69TAF15_26573619_Chip-Seq_HEK293_Human1.10652220
70OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09939261
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.09484434
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.09309819
73CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09242842
74SCL_19346495_ChIP-Seq_HPC-7_Human1.06786027
75VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02292483
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02208245
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99911095
78FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99140611
79CDX2_22108803_ChIP-Seq_LS180_Human0.99006312
80ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96966571
81GATA3_26560356_Chip-Seq_TH1_Human0.96392280
82SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.96301456
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94753102
84P300_19829295_ChIP-Seq_ESCs_Human0.93278367
85CMYC_18555785_Chip-Seq_ESCs_Mouse0.92041232
86PU_27001747_Chip-Seq_BMDM_Mouse0.91893756
87SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91307989
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90660450
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90654462
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88730021
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88730021
92EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87813738
93CIITA_25753668_ChIP-Seq_RAJI_Human0.86114409
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85936080
95NANOG_18555785_Chip-Seq_ESCs_Mouse0.85599934
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85307270
97CBP_20019798_ChIP-Seq_JUKART_Human0.85307270
98FLI1_21867929_ChIP-Seq_TH2_Mouse0.84854826
99IRF1_19129219_ChIP-ChIP_H3396_Human0.84595817
100AR_20517297_ChIP-Seq_VCAP_Human0.84120959

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.50573831
2MP0003303_peritoneal_inflammation3.01543673
3MP0001835_abnormal_antigen_presentation2.97185632
4MP0002166_altered_tumor_susceptibility2.90498137
5MP0000569_abnormal_digit_pigmentation2.57357993
6MP0008057_abnormal_DNA_replication2.45837915
7MP0003656_abnormal_erythrocyte_physiolo2.24292102
8MP0001800_abnormal_humoral_immune2.23847116
9MP0003436_decreased_susceptibility_to2.23070488
10MP0002006_tumorigenesis2.20689280
11MP0001853_heart_inflammation2.17285519
12MP0003868_abnormal_feces_composition2.13089634
13MP0005671_abnormal_response_to2.09371392
14MP0003763_abnormal_thymus_physiology2.08182229
15MP0005000_abnormal_immune_tolerance2.07868724
16MP0008260_abnormal_autophagy2.05069996
17MP0004147_increased_porphyrin_level2.04475829
18MP0002132_abnormal_respiratory_system1.99842841
19MP0009785_altered_susceptibility_to1.99199817
20MP0002419_abnormal_innate_immunity1.97741833
21MP0002723_abnormal_immune_serum1.87700093
22MP0002452_abnormal_antigen_presenting1.86450629
23MP0000372_irregular_coat_pigmentation1.85523955
24MP0001790_abnormal_immune_system1.84124864
25MP0005387_immune_system_phenotype1.84124864
26MP0008058_abnormal_DNA_repair1.80450917
27MP0001545_abnormal_hematopoietic_system1.78409267
28MP0005397_hematopoietic_system_phenotyp1.78409267
29MP0002420_abnormal_adaptive_immunity1.76784841
30MP0002396_abnormal_hematopoietic_system1.75475657
31MP0001819_abnormal_immune_cell1.74204246
32MP0004808_abnormal_hematopoietic_stem1.72069480
33MP0005075_abnormal_melanosome_morpholog1.67001946
34MP0000685_abnormal_immune_system1.65827635
35MP0002009_preneoplasia1.65704129
36MP0006054_spinal_hemorrhage1.65440845
37MP0010307_abnormal_tumor_latency1.60196750
38MP0002398_abnormal_bone_marrow1.60097233
39MP0000689_abnormal_spleen_morphology1.57573093
40MP0005025_abnormal_response_to1.55576563
41MP0003786_premature_aging1.52120472
42MP0002405_respiratory_system_inflammati1.52030096
43MP0010352_gastrointestinal_tract_polyps1.50380481
44MP0003195_calcinosis1.48428482
45MP0009764_decreased_sensitivity_to1.47614607
46MP0002736_abnormal_nociception_after1.44780543
47MP0000716_abnormal_immune_system1.44514200
48MP0002722_abnormal_immune_system1.38426229
49MP0000703_abnormal_thymus_morphology1.35988021
50MP0004381_abnormal_hair_follicle1.35655256
51MP0002138_abnormal_hepatobiliary_system1.35520947
52MP0002148_abnormal_hypersensitivity_rea1.34268891
53MP0003828_pulmonary_edema1.30559618
54MP0001845_abnormal_inflammatory_respons1.28294251
55MP0006082_CNS_inflammation1.24979454
56MP0002429_abnormal_blood_cell1.21162183
57MP0010155_abnormal_intestine_physiology1.20035564
58MP0010094_abnormal_chromosome_stability1.17194243
59MP0002928_abnormal_bile_duct1.13725807
60MP0003252_abnormal_bile_duct1.05342847
61MP0000015_abnormal_ear_pigmentation1.02686780
62MP0003866_abnormal_defecation1.01711200
63MP0001533_abnormal_skeleton_physiology1.01326707
64MP0008469_abnormal_protein_level1.00722454
65MP0001919_abnormal_reproductive_system0.98394494
66MP0008007_abnormal_cellular_replicative0.97132855
67MP0003045_fibrosis0.96962042
68MP0003221_abnormal_cardiomyocyte_apopto0.96884113
69MP0002332_abnormal_exercise_endurance0.95694886
70MP0004883_abnormal_blood_vessel0.95528665
71MP0008995_early_reproductive_senescence0.94953853
72MP0004484_altered_response_of0.94910010
73MP0000465_gastrointestinal_hemorrhage0.94624371
74MP0006036_abnormal_mitochondrial_physio0.94212055
75MP0009278_abnormal_bone_marrow0.94173470
76MP0003075_altered_response_to0.93735291
77MP0008877_abnormal_DNA_methylation0.89696512
78MP0002277_abnormal_respiratory_mucosa0.89232257
79MP0003646_muscle_fatigue0.87668968
80MP0002019_abnormal_tumor_incidence0.86797664
81MP0005084_abnormal_gallbladder_morpholo0.86700529
82MP0008004_abnormal_stomach_pH0.85455143
83MP0003300_gastrointestinal_ulcer0.84088644
84MP0005164_abnormal_response_to0.83773209
85MP0003172_abnormal_lysosome_physiology0.80118956
86MP0000371_diluted_coat_color0.79866814
87MP0005266_abnormal_metabolism0.78662975
88MP0005166_decreased_susceptibility_to0.78050809
89MP0005464_abnormal_platelet_physiology0.76713455
90MP0008873_increased_physiological_sensi0.76126655
91MP0003077_abnormal_cell_cycle0.75967589
92MP0001764_abnormal_homeostasis0.75682880
93MP0004947_skin_inflammation0.75392525
94MP0005535_abnormal_body_temperature0.74420473
95MP0008961_abnormal_basal_metabolism0.73785149
96MP0005451_abnormal_body_composition0.72492759
97MP0005367_renal/urinary_system_phenotyp0.72472340
98MP0000516_abnormal_urinary_system0.72472340
99MP0003111_abnormal_nucleus_morphology0.70010449
100MP0009765_abnormal_xenobiotic_induced0.67935762

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.67187866
2Abnormal delayed hypersensitivity skin test (HP:0002963)4.32217028
3Recurrent bacterial skin infections (HP:0005406)4.04843294
4Stomatitis (HP:0010280)3.94336988
5Retrobulbar optic neuritis (HP:0100654)3.72049029
6Optic neuritis (HP:0100653)3.72049029
7Myositis (HP:0100614)3.65455764
8Cutaneous melanoma (HP:0012056)3.61949992
9Recurrent abscess formation (HP:0002722)3.61249535
10Panhypogammaglobulinemia (HP:0003139)3.37756675
11Recurrent cutaneous fungal infections (HP:0011370)3.37286718
12Chronic mucocutaneous candidiasis (HP:0002728)3.37286718
13Abnormality of T cell physiology (HP:0011840)3.29237001
14Recurrent skin infections (HP:0001581)3.22149112
15Orchitis (HP:0100796)3.19390887
16Recurrent fungal infections (HP:0002841)3.11817949
17Meningioma (HP:0002858)3.09658881
18T lymphocytopenia (HP:0005403)2.96638780
19Abnormality of T cell number (HP:0011839)2.91003356
20Abnormality of T cells (HP:0002843)2.83600942
21Thyroiditis (HP:0100646)2.82327386
22Abnormal hair whorl (HP:0010721)2.73671861
23Arterial thrombosis (HP:0004420)2.72539739
24Keratoconjunctivitis sicca (HP:0001097)2.72268757
25Recurrent viral infections (HP:0004429)2.68033436
26Abnormality of B cell number (HP:0010975)2.67783988
27IgG deficiency (HP:0004315)2.62944105
28IgM deficiency (HP:0002850)2.59259609
29Abnormality of the fingertips (HP:0001211)2.58361279
30Keratoconjunctivitis (HP:0001096)2.49658106
31Autoimmune hemolytic anemia (HP:0001890)2.45396516
32B lymphocytopenia (HP:0010976)2.43627605
33Meningitis (HP:0001287)2.41355283
34Acute myeloid leukemia (HP:0004808)2.33483718
35Pustule (HP:0200039)2.30591723
36Mediastinal lymphadenopathy (HP:0100721)2.26276359
37Gastrointestinal infarctions (HP:0005244)2.24388794
38Vasculitis (HP:0002633)2.22727618
39Encephalitis (HP:0002383)2.22721368
40Aqueductal stenosis (HP:0002410)2.21259564
41Eczematoid dermatitis (HP:0000976)2.21021120
42Abnormality of the prostate (HP:0008775)2.19063385
43Pulmonary infiltrates (HP:0002113)2.13012032
44Narrow palate (HP:0000189)2.11291080
45Viral hepatitis (HP:0006562)2.10494998
46Intestinal fistula (HP:0100819)2.07636630
47Myelodysplasia (HP:0002863)2.05441219
48Abnormality of incisor morphology (HP:0011063)2.04382910
49Abnormality of the pleura (HP:0002103)2.04079455
50Supernumerary spleens (HP:0009799)2.03411092
51Hemoptysis (HP:0002105)2.02827059
52Anorexia (HP:0002039)2.00924272
53Gangrene (HP:0100758)1.97074712
54Severe combined immunodeficiency (HP:0004430)1.96028367
55Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.94205325
56Clubbing of toes (HP:0100760)1.94056101
57Abnormality of chromosome stability (HP:0003220)1.93378906
58Hematochezia (HP:0002573)1.93364573
59Papilledema (HP:0001085)1.90493469
60Agammaglobulinemia (HP:0004432)1.90413928
61Curly hair (HP:0002212)1.89929091
62Rectovaginal fistula (HP:0000143)1.89135008
63Rectal fistula (HP:0100590)1.89135008
64Lower limb hyperreflexia (HP:0002395)1.88489474
65Progressive inability to walk (HP:0002505)1.88073007
66Stomach cancer (HP:0012126)1.88026915
67Albinism (HP:0001022)1.87532828
68Basal cell carcinoma (HP:0002671)1.86181842
69Chest pain (HP:0100749)1.83505056
70Prominent nose (HP:0000448)1.83071682
71Autoimmune thrombocytopenia (HP:0001973)1.82809907
72Facial diplegia (HP:0001349)1.82045230
73Leukocytosis (HP:0001974)1.80937377
74Abnormality of the labia minora (HP:0012880)1.80141636
75Poikilocytosis (HP:0004447)1.80128016
76Degeneration of the lateral corticospinal tracts (HP:0002314)1.80044629
77Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.80044629
78Methylmalonic acidemia (HP:0002912)1.79818826
79Alveolar cell carcinoma (HP:0006519)1.78847748
80Thyroid carcinoma (HP:0002890)1.77791589
81Neoplasm of the tracheobronchial system (HP:0100552)1.76623465
82Eosinophilia (HP:0001880)1.74954715
83Osteomyelitis (HP:0002754)1.74582256
84Episodic fever (HP:0001954)1.72360484
85Amaurosis fugax (HP:0100576)1.70985872
86Abnormality of eosinophils (HP:0001879)1.70695501
87Hyperventilation (HP:0002883)1.69598006
88Granulocytopenia (HP:0001913)1.68468948
89Ocular albinism (HP:0001107)1.68113847
90Pulmonary embolism (HP:0002204)1.67470509
91Abnormality of male internal genitalia (HP:0000022)1.67374219
92Parakeratosis (HP:0001036)1.64628034
93Methylmalonic aciduria (HP:0012120)1.62827050
94Spastic paraparesis (HP:0002313)1.60724577
95Abnormality of methionine metabolism (HP:0010901)1.60110872
96Neutropenia (HP:0001875)1.59983721
97Colitis (HP:0002583)1.59886904
98Muscle fibrillation (HP:0010546)1.57489214
99Medial flaring of the eyebrow (HP:0010747)1.55203298
100Abnormality of the heme biosynthetic pathway (HP:0010472)1.55110812

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.46413420
2NUAK13.06475511
3TAOK33.02732176
4EIF2AK32.95016977
5TXK2.69509872
6TLK12.55913645
7BMPR22.45926067
8MST42.39988601
9ZAK2.16133370
10MKNK22.13456206
11MKNK12.02689096
12TEC1.97330737
13IRAK11.90547985
14BRD41.77513827
15BLK1.72929196
16NLK1.61216833
17MAP4K11.53100646
18MARK31.52925994
19PIK3CG1.52201146
20TYK21.50301218
21MAP3K141.46157793
22RAF11.45696188
23GRK61.45235196
24ACVR1B1.45159974
25MAP2K31.34719416
26PLK41.29550533
27PLK31.26691755
28BTK1.26563325
29IKBKE1.23893870
30TNIK1.22890202
31FGFR31.17143016
32BRSK21.16433274
33RIPK41.15279787
34SRPK11.12839957
35ITK1.12349760
36IRAK41.10637974
37EIF2AK21.08534972
38ERBB31.08276328
39JAK11.07967875
40MAP3K21.07248847
41SYK1.06112646
42EIF2AK11.05735271
43JAK21.04003418
44IKBKB0.99894145
45HCK0.98183426
46WEE10.97958204
47MAP2K60.97097529
48SGK20.96572084
49PLK20.96152209
50FGFR20.93856951
51STK160.93455059
52VRK10.90345736
53TRPM70.86702885
54CSK0.84901190
55MAP4K20.79441100
56DYRK30.77480016
57TSSK60.77357978
58RPS6KA50.74621674
59PDK20.73505542
60LYN0.71354423
61MATK0.70191826
62WNK10.68914840
63JAK30.67967046
64CHUK0.67066816
65DMPK0.66511764
66LCK0.63964208
67PIM10.62898994
68AKT30.62873405
69RPS6KA40.61409204
70MAP3K120.61034646
71MAPK150.60320267
72STK40.59845526
73YES10.59316633
74FES0.58202783
75SIK30.56833310
76PTK2B0.55211689
77PRPF4B0.53177237
78OXSR10.52221356
79MAP3K50.49515961
80CAMK1D0.48698521
81KIT0.48163147
82STK38L0.47955203
83KSR20.47513454
84PRKCQ0.47037815
85BMPR1B0.46321008
86ZAP700.46285174
87ERBB20.45860509
88DAPK20.42860331
89EPHB10.41763544
90ATM0.40515378
91CAMK40.38985102
92EPHA30.38750970
93STK30.37875713
94SGK30.37604151
95TBK10.37063056
96PRKAA20.35710392
97RPS6KB20.33333185
98MAPK130.32731585
99PKN10.31795730
100SGK10.29856414

Predicted pathways (KEGG)

RankGene SetZ-score
1NOD-like receptor signaling pathway_Homo sapiens_hsa046212.60848120
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.53367808
3Leishmaniasis_Homo sapiens_hsa051402.39205587
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.30840612
5Protein export_Homo sapiens_hsa030602.30197644
6Graft-versus-host disease_Homo sapiens_hsa053322.29295688
7Allograft rejection_Homo sapiens_hsa053302.20872740
8Asthma_Homo sapiens_hsa053102.17812657
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.17705808
10Legionellosis_Homo sapiens_hsa051342.14759273
11Autoimmune thyroid disease_Homo sapiens_hsa053202.02783388
12Type I diabetes mellitus_Homo sapiens_hsa049401.98669514
13Propanoate metabolism_Homo sapiens_hsa006401.97363801
14Osteoclast differentiation_Homo sapiens_hsa043801.94022581
15Systemic lupus erythematosus_Homo sapiens_hsa053221.85955695
16Measles_Homo sapiens_hsa051621.79149286
17TNF signaling pathway_Homo sapiens_hsa046681.74853168
18Proteasome_Homo sapiens_hsa030501.69535663
19Influenza A_Homo sapiens_hsa051641.69366557
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.64099665
21Non-homologous end-joining_Homo sapiens_hsa034501.63942097
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.60444309
23RNA degradation_Homo sapiens_hsa030181.59531216
24Herpes simplex infection_Homo sapiens_hsa051681.58982979
25B cell receptor signaling pathway_Homo sapiens_hsa046621.55515964
26Staphylococcus aureus infection_Homo sapiens_hsa051501.49003794
27Antigen processing and presentation_Homo sapiens_hsa046121.43793152
28Tuberculosis_Homo sapiens_hsa051521.43170499
29Homologous recombination_Homo sapiens_hsa034401.40720840
30Circadian rhythm_Homo sapiens_hsa047101.39330115
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37369392
32Hepatitis B_Homo sapiens_hsa051611.35458332
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.34452582
34Malaria_Homo sapiens_hsa051441.33450898
35T cell receptor signaling pathway_Homo sapiens_hsa046601.31738249
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.31460150
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31391832
38One carbon pool by folate_Homo sapiens_hsa006701.29152928
39Toxoplasmosis_Homo sapiens_hsa051451.21687589
40Primary immunodeficiency_Homo sapiens_hsa053401.20263820
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19498534
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16668888
43Regulation of autophagy_Homo sapiens_hsa041401.14074493
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.07585442
45Hematopoietic cell lineage_Homo sapiens_hsa046401.06942127
46African trypanosomiasis_Homo sapiens_hsa051431.06868888
47Epstein-Barr virus infection_Homo sapiens_hsa051691.06608785
48FoxO signaling pathway_Homo sapiens_hsa040680.96657705
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95114346
50Fanconi anemia pathway_Homo sapiens_hsa034600.94162857
51Viral carcinogenesis_Homo sapiens_hsa052030.91597256
52Prostate cancer_Homo sapiens_hsa052150.89427878
53HIF-1 signaling pathway_Homo sapiens_hsa040660.88984972
54Dorso-ventral axis formation_Homo sapiens_hsa043200.88824093
55Basal transcription factors_Homo sapiens_hsa030220.84553470
56Rheumatoid arthritis_Homo sapiens_hsa053230.84205406
57Non-small cell lung cancer_Homo sapiens_hsa052230.83606588
58Prolactin signaling pathway_Homo sapiens_hsa049170.82700812
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82662302
60Acute myeloid leukemia_Homo sapiens_hsa052210.82093103
61Type II diabetes mellitus_Homo sapiens_hsa049300.80494971
62Alcoholism_Homo sapiens_hsa050340.78220568
63Platelet activation_Homo sapiens_hsa046110.77233230
64Nucleotide excision repair_Homo sapiens_hsa034200.74485792
65mRNA surveillance pathway_Homo sapiens_hsa030150.72882382
66p53 signaling pathway_Homo sapiens_hsa041150.72792046
67Mismatch repair_Homo sapiens_hsa034300.67236150
68Pertussis_Homo sapiens_hsa051330.65533745
69Insulin resistance_Homo sapiens_hsa049310.60915067
70DNA replication_Homo sapiens_hsa030300.58973345
71RNA polymerase_Homo sapiens_hsa030200.58376584
72Hepatitis C_Homo sapiens_hsa051600.57631051
73mTOR signaling pathway_Homo sapiens_hsa041500.56765772
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56106208
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55120770
76Renal cell carcinoma_Homo sapiens_hsa052110.54734913
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52338702
78RNA transport_Homo sapiens_hsa030130.51876665
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51552006
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51510440
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.50142266
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49915435
83Pancreatic cancer_Homo sapiens_hsa052120.49803688
84Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48566576
85Tryptophan metabolism_Homo sapiens_hsa003800.47982681
86Chemokine signaling pathway_Homo sapiens_hsa040620.47159298
87Spliceosome_Homo sapiens_hsa030400.45036980
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44434063
89Colorectal cancer_Homo sapiens_hsa052100.44379778
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43785822
91HTLV-I infection_Homo sapiens_hsa051660.43164486
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42729120
93Linoleic acid metabolism_Homo sapiens_hsa005910.39090532
94Nitrogen metabolism_Homo sapiens_hsa009100.38711948
95Apoptosis_Homo sapiens_hsa042100.38497035
96Lysine degradation_Homo sapiens_hsa003100.38417498
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37901365
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35514687
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34286582
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.32084854

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