

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proteasome assembly (GO:0043248) | 6.74642033 |
| 2 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.25257062 |
| 3 | DNA deamination (GO:0045006) | 4.74723144 |
| 4 | ATP synthesis coupled proton transport (GO:0015986) | 4.56828451 |
| 5 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.56828451 |
| 6 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.37741588 |
| 7 | protein neddylation (GO:0045116) | 4.18040058 |
| 8 | DNA replication checkpoint (GO:0000076) | 4.10191389 |
| 9 | regulation of mitochondrial translation (GO:0070129) | 4.08831959 |
| 10 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.08552142 |
| 11 | termination of RNA polymerase III transcription (GO:0006386) | 4.08552142 |
| 12 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.06606211 |
| 13 | CENP-A containing nucleosome assembly (GO:0034080) | 3.98860717 |
| 14 | platelet dense granule organization (GO:0060155) | 3.90675163 |
| 15 | chromatin remodeling at centromere (GO:0031055) | 3.90502337 |
| 16 | response to pheromone (GO:0019236) | 3.86839627 |
| 17 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.80299729 |
| 18 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.77172122 |
| 19 | organelle disassembly (GO:1903008) | 3.74783080 |
| 20 | protein complex biogenesis (GO:0070271) | 3.74578246 |
| 21 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.73842451 |
| 22 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.71699030 |
| 23 | rRNA modification (GO:0000154) | 3.70690698 |
| 24 | respiratory chain complex IV assembly (GO:0008535) | 3.70464550 |
| 25 | cytochrome complex assembly (GO:0017004) | 3.70239205 |
| 26 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.68814714 |
| 27 | negative regulation of ligase activity (GO:0051352) | 3.68814714 |
| 28 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.67978187 |
| 29 | rRNA methylation (GO:0031167) | 3.64845392 |
| 30 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.56861251 |
| 31 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.55736808 |
| 32 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.55615006 |
| 33 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.55615006 |
| 34 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.55615006 |
| 35 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.50216276 |
| 36 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.50192130 |
| 37 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.45687709 |
| 38 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.45687709 |
| 39 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.43846802 |
| 40 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.43846802 |
| 41 | NADH dehydrogenase complex assembly (GO:0010257) | 3.43846802 |
| 42 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.43263596 |
| 43 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.43263596 |
| 44 | regulation of relaxation of muscle (GO:1901077) | 3.42890836 |
| 45 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.41414455 |
| 46 | DNA double-strand break processing (GO:0000729) | 3.41114615 |
| 47 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.40780864 |
| 48 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.39049744 |
| 49 | respiratory electron transport chain (GO:0022904) | 3.36017841 |
| 50 | electron transport chain (GO:0022900) | 3.35834343 |
| 51 | ribonucleoprotein complex disassembly (GO:0032988) | 3.33823183 |
| 52 | neural tube formation (GO:0001841) | 3.32140181 |
| 53 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.30098216 |
| 54 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.30098216 |
| 55 | replication fork processing (GO:0031297) | 3.29469830 |
| 56 | regulation of cell communication by electrical coupling (GO:0010649) | 3.28218097 |
| 57 | DNA ligation (GO:0006266) | 3.22512908 |
| 58 | amino acid salvage (GO:0043102) | 3.17699726 |
| 59 | L-methionine salvage (GO:0071267) | 3.17699726 |
| 60 | L-methionine biosynthetic process (GO:0071265) | 3.17699726 |
| 61 | histone exchange (GO:0043486) | 3.17034787 |
| 62 | cytidine deamination (GO:0009972) | 3.16015947 |
| 63 | cytidine metabolic process (GO:0046087) | 3.16015947 |
| 64 | cytidine catabolic process (GO:0006216) | 3.16015947 |
| 65 | kinetochore organization (GO:0051383) | 3.15096441 |
| 66 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.12080512 |
| 67 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.10491867 |
| 68 | regulation of action potential (GO:0098900) | 3.10243125 |
| 69 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.09398212 |
| 70 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.09398212 |
| 71 | negative regulation of sodium ion transport (GO:0010766) | 3.05452349 |
| 72 | histone mRNA metabolic process (GO:0008334) | 3.02364623 |
| 73 | lactate metabolic process (GO:0006089) | 3.02318169 |
| 74 | mannosylation (GO:0097502) | 3.02169972 |
| 75 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.01789437 |
| 76 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.01789437 |
| 77 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.00744494 |
| 78 | viral mRNA export from host cell nucleus (GO:0046784) | 3.00154753 |
| 79 | kinetochore assembly (GO:0051382) | 2.96327481 |
| 80 | positive regulation of ligase activity (GO:0051351) | 2.95071413 |
| 81 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.92081774 |
| 82 | inner mitochondrial membrane organization (GO:0007007) | 2.90235462 |
| 83 | GPI anchor biosynthetic process (GO:0006506) | 2.89413444 |
| 84 | GPI anchor metabolic process (GO:0006505) | 2.89248601 |
| 85 | DNA replication-independent nucleosome organization (GO:0034724) | 2.88595583 |
| 86 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.88595583 |
| 87 | IMP biosynthetic process (GO:0006188) | 2.87425214 |
| 88 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 2.86674918 |
| 89 | transcription from RNA polymerase III promoter (GO:0006383) | 2.83000094 |
| 90 | ribosome biogenesis (GO:0042254) | 2.81122736 |
| 91 | signal peptide processing (GO:0006465) | 2.80421022 |
| 92 | hepatocyte apoptotic process (GO:0097284) | 2.78663079 |
| 93 | ATP biosynthetic process (GO:0006754) | 2.78168937 |
| 94 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.75173915 |
| 95 | pseudouridine synthesis (GO:0001522) | 2.75086835 |
| 96 | ribosome assembly (GO:0042255) | 2.73844789 |
| 97 | chaperone-mediated protein transport (GO:0072321) | 2.73666535 |
| 98 | DNA-templated transcription, termination (GO:0006353) | 2.72856813 |
| 99 | artery smooth muscle contraction (GO:0014824) | 2.71644051 |
| 100 | C-terminal protein lipidation (GO:0006501) | 2.70983492 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.20486183 |
| 2 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 4.70746601 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.53443142 |
| 4 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.24168623 |
| 5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.77931404 |
| 6 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.51283232 |
| 7 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.09304485 |
| 8 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.92225480 |
| 9 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.91228653 |
| 10 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.84367852 |
| 11 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.71603872 |
| 12 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.66899137 |
| 13 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.61277462 |
| 14 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.55565572 |
| 15 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.55405196 |
| 16 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.52608816 |
| 17 | VDR_22108803_ChIP-Seq_LS180_Human | 2.51102879 |
| 18 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.34269184 |
| 19 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.32542935 |
| 20 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.30448865 |
| 21 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.27799862 |
| 22 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.20724963 |
| 23 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.18585711 |
| 24 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 2.03848990 |
| 25 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.92731312 |
| 26 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.85652095 |
| 27 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.79800426 |
| 28 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.77656140 |
| 29 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.74642533 |
| 30 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.74389470 |
| 31 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.73301101 |
| 32 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.71746386 |
| 33 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.65653081 |
| 34 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.65614204 |
| 35 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.60477302 |
| 36 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.55772524 |
| 37 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.53707471 |
| 38 | EWS_26573619_Chip-Seq_HEK293_Human | 1.53009614 |
| 39 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.50334136 |
| 40 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.49816418 |
| 41 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.46694314 |
| 42 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.44941990 |
| 43 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.42858188 |
| 44 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.42062796 |
| 45 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.35515645 |
| 46 | FUS_26573619_Chip-Seq_HEK293_Human | 1.31428134 |
| 47 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.31035813 |
| 48 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.30952275 |
| 49 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.28693128 |
| 50 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.27582457 |
| 51 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.26645927 |
| 52 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.24941876 |
| 53 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.23041816 |
| 54 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.22085555 |
| 55 | P300_19829295_ChIP-Seq_ESCs_Human | 1.21942713 |
| 56 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.21815550 |
| 57 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.21792253 |
| 58 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.20361959 |
| 59 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.19030909 |
| 60 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.17843969 |
| 61 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.12991086 |
| 62 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.12967734 |
| 63 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.12900921 |
| 64 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.12726110 |
| 65 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.12410323 |
| 66 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.11827965 |
| 67 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.11827965 |
| 68 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.11769232 |
| 69 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.10981765 |
| 70 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.09030197 |
| 71 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.05528482 |
| 72 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.05083733 |
| 73 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.04391844 |
| 74 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.03921407 |
| 75 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.03134126 |
| 76 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.01152064 |
| 77 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.00496818 |
| 78 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.99921540 |
| 79 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.99635615 |
| 80 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.97368975 |
| 81 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.96990233 |
| 82 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.96323939 |
| 83 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.94396445 |
| 84 | PHF8_20622853_ChIP-Seq_HELA_Human | 0.93969189 |
| 85 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.93287076 |
| 86 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.93271462 |
| 87 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.93042036 |
| 88 | AR_20517297_ChIP-Seq_VCAP_Human | 0.92711491 |
| 89 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.91106812 |
| 90 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.90888489 |
| 91 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.89519775 |
| 92 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.89260598 |
| 93 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.88847966 |
| 94 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.88847966 |
| 95 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 0.88462442 |
| 96 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.88068502 |
| 97 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.87326185 |
| 98 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.86646085 |
| 99 | CDX2_22108803_ChIP-Seq_LS180_Human | 0.86298061 |
| 100 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.83017389 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003806_abnormal_nucleotide_metabolis | 5.08571515 |
| 2 | MP0006054_spinal_hemorrhage | 4.46395625 |
| 3 | MP0009697_abnormal_copulation | 4.01766374 |
| 4 | MP0002254_reproductive_system_inflammat | 3.77256896 |
| 5 | MP0010094_abnormal_chromosome_stability | 3.22395740 |
| 6 | MP0002102_abnormal_ear_morphology | 2.91933093 |
| 7 | MP0000372_irregular_coat_pigmentation | 2.77650673 |
| 8 | MP0008058_abnormal_DNA_repair | 2.74984892 |
| 9 | MP0003786_premature_aging | 2.39696137 |
| 10 | MP0003195_calcinosis | 2.34984994 |
| 11 | MP0006072_abnormal_retinal_apoptosis | 2.29781990 |
| 12 | MP0002396_abnormal_hematopoietic_system | 2.28385645 |
| 13 | MP0003136_yellow_coat_color | 2.20044136 |
| 14 | MP0003111_abnormal_nucleus_morphology | 2.17748992 |
| 15 | MP0002928_abnormal_bile_duct | 2.02319638 |
| 16 | MP0005084_abnormal_gallbladder_morpholo | 2.00284015 |
| 17 | MP0003252_abnormal_bile_duct | 1.96893102 |
| 18 | MP0002837_dystrophic_cardiac_calcinosis | 1.90495997 |
| 19 | MP0005075_abnormal_melanosome_morpholog | 1.88960585 |
| 20 | MP0001984_abnormal_olfaction | 1.81765187 |
| 21 | MP0005671_abnormal_response_to | 1.80912736 |
| 22 | MP0003718_maternal_effect | 1.77285884 |
| 23 | MP0001529_abnormal_vocalization | 1.76018274 |
| 24 | MP0005253_abnormal_eye_physiology | 1.68983265 |
| 25 | MP0003693_abnormal_embryo_hatching | 1.68942365 |
| 26 | MP0003221_abnormal_cardiomyocyte_apopto | 1.61212294 |
| 27 | MP0008995_early_reproductive_senescence | 1.58523847 |
| 28 | MP0005551_abnormal_eye_electrophysiolog | 1.56344219 |
| 29 | MP0002166_altered_tumor_susceptibility | 1.54015373 |
| 30 | MP0008932_abnormal_embryonic_tissue | 1.53173402 |
| 31 | MP0003880_abnormal_central_pattern | 1.52632719 |
| 32 | MP0004957_abnormal_blastocyst_morpholog | 1.48369708 |
| 33 | MP0003077_abnormal_cell_cycle | 1.47842739 |
| 34 | MP0006036_abnormal_mitochondrial_physio | 1.47718201 |
| 35 | MP0005645_abnormal_hypothalamus_physiol | 1.44802540 |
| 36 | MP0005379_endocrine/exocrine_gland_phen | 1.44588613 |
| 37 | MP0008872_abnormal_physiological_respon | 1.43929923 |
| 38 | MP0008007_abnormal_cellular_replicative | 1.43076655 |
| 39 | MP0005360_urolithiasis | 1.33271679 |
| 40 | MP0010352_gastrointestinal_tract_polyps | 1.30735029 |
| 41 | MP0002938_white_spotting | 1.28077095 |
| 42 | MP0001764_abnormal_homeostasis | 1.21711405 |
| 43 | MP0005187_abnormal_penis_morphology | 1.20846614 |
| 44 | MP0004215_abnormal_myocardial_fiber | 1.19759471 |
| 45 | MP0006035_abnormal_mitochondrial_morpho | 1.18526805 |
| 46 | MP0002006_tumorigenesis | 1.16558583 |
| 47 | MP0002090_abnormal_vision | 1.14841522 |
| 48 | MP0001485_abnormal_pinna_reflex | 1.09109691 |
| 49 | MP0001919_abnormal_reproductive_system | 1.06814151 |
| 50 | MP0001929_abnormal_gametogenesis | 1.06239809 |
| 51 | MP0002736_abnormal_nociception_after | 1.05235906 |
| 52 | MP0002163_abnormal_gland_morphology | 1.05138783 |
| 53 | MP0003186_abnormal_redox_activity | 1.04834888 |
| 54 | MP0005389_reproductive_system_phenotype | 1.04675962 |
| 55 | MP0008877_abnormal_DNA_methylation | 1.01516538 |
| 56 | MP0003011_delayed_dark_adaptation | 1.01137815 |
| 57 | MP0005410_abnormal_fertilization | 0.97873969 |
| 58 | MP0008789_abnormal_olfactory_epithelium | 0.97109799 |
| 59 | MP0008057_abnormal_DNA_replication | 0.95752961 |
| 60 | MP0000653_abnormal_sex_gland | 0.95718724 |
| 61 | MP0002210_abnormal_sex_determination | 0.95330593 |
| 62 | MP0002160_abnormal_reproductive_system | 0.94723354 |
| 63 | MP0003119_abnormal_digestive_system | 0.94171140 |
| 64 | MP0005636_abnormal_mineral_homeostasis | 0.92315325 |
| 65 | MP0005395_other_phenotype | 0.91545327 |
| 66 | MP0005174_abnormal_tail_pigmentation | 0.87548711 |
| 67 | MP0004484_altered_response_of | 0.86974591 |
| 68 | MP0002751_abnormal_autonomic_nervous | 0.85997573 |
| 69 | MP0003937_abnormal_limbs/digits/tail_de | 0.85832928 |
| 70 | MP0005332_abnormal_amino_acid | 0.85305090 |
| 71 | MP0000569_abnormal_digit_pigmentation | 0.84945888 |
| 72 | MP0004019_abnormal_vitamin_homeostasis | 0.84711815 |
| 73 | MP0003698_abnormal_male_reproductive | 0.84513033 |
| 74 | MP0004147_increased_porphyrin_level | 0.84412917 |
| 75 | MP0001835_abnormal_antigen_presentation | 0.83632097 |
| 76 | MP0004084_abnormal_cardiac_muscle | 0.83250811 |
| 77 | MP0005310_abnormal_salivary_gland | 0.82398939 |
| 78 | MP0001119_abnormal_female_reproductive | 0.81179261 |
| 79 | MP0001661_extended_life_span | 0.81151619 |
| 80 | MP0001293_anophthalmia | 0.79545668 |
| 81 | MP0001145_abnormal_male_reproductive | 0.79269676 |
| 82 | MP0001968_abnormal_touch/_nociception | 0.78249663 |
| 83 | MP0005391_vision/eye_phenotype | 0.78001751 |
| 84 | MP0001756_abnormal_urination | 0.76873974 |
| 85 | MP0005319_abnormal_enzyme/_coenzyme | 0.74380509 |
| 86 | MP0005376_homeostasis/metabolism_phenot | 0.72415115 |
| 87 | MP0002095_abnormal_skin_pigmentation | 0.72158050 |
| 88 | MP0000383_abnormal_hair_follicle | 0.71731043 |
| 89 | MP0008875_abnormal_xenobiotic_pharmacok | 0.70477562 |
| 90 | MP0004381_abnormal_hair_follicle | 0.63771514 |
| 91 | MP0005195_abnormal_posterior_eye | 0.63723803 |
| 92 | MP0002138_abnormal_hepatobiliary_system | 0.63144590 |
| 93 | MP0001666_abnormal_nutrient_absorption | 0.61532662 |
| 94 | MP0005220_abnormal_exocrine_pancreas | 0.61498542 |
| 95 | MP0002909_abnormal_adrenal_gland | 0.60884340 |
| 96 | MP0005167_abnormal_blood-brain_barrier | 0.59638351 |
| 97 | MP0005365_abnormal_bile_salt | 0.59075497 |
| 98 | MP0005266_abnormal_metabolism | 0.58734471 |
| 99 | MP0010307_abnormal_tumor_latency | 0.58720970 |
| 100 | MP0000358_abnormal_cell_content/ | 0.55431688 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.83732878 |
| 2 | Acute encephalopathy (HP:0006846) | 4.41796871 |
| 3 | Mitochondrial inheritance (HP:0001427) | 4.31666763 |
| 4 | Progressive macrocephaly (HP:0004481) | 4.12460693 |
| 5 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.06609546 |
| 6 | Increased CSF lactate (HP:0002490) | 4.01016796 |
| 7 | Congenital, generalized hypertrichosis (HP:0004540) | 3.86475068 |
| 8 | Hepatocellular necrosis (HP:0001404) | 3.76558163 |
| 9 | Hepatic necrosis (HP:0002605) | 3.34704289 |
| 10 | Increased hepatocellular lipid droplets (HP:0006565) | 3.27608273 |
| 11 | Meckel diverticulum (HP:0002245) | 3.20895669 |
| 12 | Lipid accumulation in hepatocytes (HP:0006561) | 3.19782942 |
| 13 | Cerebral edema (HP:0002181) | 3.16772533 |
| 14 | 3-Methylglutaconic aciduria (HP:0003535) | 3.10701815 |
| 15 | Methylmalonic aciduria (HP:0012120) | 3.07517713 |
| 16 | Abnormality of the ileum (HP:0001549) | 3.06938294 |
| 17 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.06798470 |
| 18 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 3.03878631 |
| 19 | Abnormality of chromosome stability (HP:0003220) | 2.94757211 |
| 20 | Pancreatic cysts (HP:0001737) | 2.91772898 |
| 21 | Cerebral hypomyelination (HP:0006808) | 2.82406264 |
| 22 | Increased serum lactate (HP:0002151) | 2.73971888 |
| 23 | Chromsome breakage (HP:0040012) | 2.67555613 |
| 24 | Abnormal number of erythroid precursors (HP:0012131) | 2.63432025 |
| 25 | Abnormality of the preputium (HP:0100587) | 2.63288889 |
| 26 | Increased serum pyruvate (HP:0003542) | 2.60524072 |
| 27 | Lactic acidosis (HP:0003128) | 2.60436554 |
| 28 | Optic disc pallor (HP:0000543) | 2.59955472 |
| 29 | Methylmalonic acidemia (HP:0002912) | 2.59105504 |
| 30 | Abnormality of methionine metabolism (HP:0010901) | 2.50713928 |
| 31 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.46541524 |
| 32 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.46424148 |
| 33 | Type I transferrin isoform profile (HP:0003642) | 2.46081903 |
| 34 | Pancreatic fibrosis (HP:0100732) | 2.44374686 |
| 35 | Chronic diarrhea (HP:0002028) | 2.42673750 |
| 36 | Clubbing of toes (HP:0100760) | 2.40976866 |
| 37 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.40648589 |
| 38 | Respiratory failure (HP:0002878) | 2.39987145 |
| 39 | Lethargy (HP:0001254) | 2.38294028 |
| 40 | Hyperglycinemia (HP:0002154) | 2.34802502 |
| 41 | Congenital stationary night blindness (HP:0007642) | 2.34471858 |
| 42 | Absent thumb (HP:0009777) | 2.34372339 |
| 43 | Leukodystrophy (HP:0002415) | 2.33009940 |
| 44 | Posterior subcapsular cataract (HP:0007787) | 2.29997898 |
| 45 | True hermaphroditism (HP:0010459) | 2.29537297 |
| 46 | Molar tooth sign on MRI (HP:0002419) | 2.27628234 |
| 47 | Abnormality of midbrain morphology (HP:0002418) | 2.27628234 |
| 48 | Respiratory difficulties (HP:0002880) | 2.25504265 |
| 49 | Hypoglycemic coma (HP:0001325) | 2.25289844 |
| 50 | Duodenal stenosis (HP:0100867) | 2.24314957 |
| 51 | Small intestinal stenosis (HP:0012848) | 2.24314957 |
| 52 | Renal Fanconi syndrome (HP:0001994) | 2.24238046 |
| 53 | Hypoplasia of the pons (HP:0012110) | 2.22701861 |
| 54 | Triphalangeal thumb (HP:0001199) | 2.21931982 |
| 55 | Abnormality of glycolysis (HP:0004366) | 2.18917356 |
| 56 | Abnormality of T cell physiology (HP:0011840) | 2.18206258 |
| 57 | Renal cortical cysts (HP:0000803) | 2.18127598 |
| 58 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.15954557 |
| 59 | Hypoproteinemia (HP:0003075) | 2.15804992 |
| 60 | Amelogenesis imperfecta (HP:0000705) | 2.14850609 |
| 61 | Type 2 muscle fiber atrophy (HP:0003554) | 2.13908720 |
| 62 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 2.11478546 |
| 63 | Hypoplasia of the fovea (HP:0007750) | 2.11478546 |
| 64 | Constricted visual fields (HP:0001133) | 2.07447580 |
| 65 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.06883572 |
| 66 | Abnormality of alanine metabolism (HP:0010916) | 2.06098562 |
| 67 | Hyperalaninemia (HP:0003348) | 2.06098562 |
| 68 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.06098562 |
| 69 | Abnormality of serum amino acid levels (HP:0003112) | 2.04820718 |
| 70 | Hypoglycemic seizures (HP:0002173) | 2.04251304 |
| 71 | Abnormality of the duodenum (HP:0002246) | 2.03801427 |
| 72 | Abnormality of the pons (HP:0007361) | 2.03432828 |
| 73 | Exertional dyspnea (HP:0002875) | 2.01459321 |
| 74 | Colon cancer (HP:0003003) | 1.97745059 |
| 75 | Microvesicular hepatic steatosis (HP:0001414) | 1.97743952 |
| 76 | Nephronophthisis (HP:0000090) | 1.96933281 |
| 77 | Amniotic constriction ring (HP:0009775) | 1.96778612 |
| 78 | Abnormality of placental membranes (HP:0011409) | 1.96778612 |
| 79 | Symptomatic seizures (HP:0011145) | 1.94917768 |
| 80 | CNS demyelination (HP:0007305) | 1.92564193 |
| 81 | Sloping forehead (HP:0000340) | 1.90687633 |
| 82 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.88106326 |
| 83 | Abnormal protein glycosylation (HP:0012346) | 1.88106326 |
| 84 | Abnormal glycosylation (HP:0012345) | 1.88106326 |
| 85 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.88106326 |
| 86 | Reticulocytopenia (HP:0001896) | 1.86636631 |
| 87 | Exercise intolerance (HP:0003546) | 1.86344620 |
| 88 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.84070572 |
| 89 | Abnormality of the fovea (HP:0000493) | 1.83754686 |
| 90 | Abnormality of the labia minora (HP:0012880) | 1.83344287 |
| 91 | Duplicated collecting system (HP:0000081) | 1.82832744 |
| 92 | Abolished electroretinogram (ERG) (HP:0000550) | 1.77781209 |
| 93 | Attenuation of retinal blood vessels (HP:0007843) | 1.75969013 |
| 94 | Prolonged partial thromboplastin time (HP:0003645) | 1.75867029 |
| 95 | CNS hypomyelination (HP:0003429) | 1.74860255 |
| 96 | Hyperglycinuria (HP:0003108) | 1.74783171 |
| 97 | Thyroiditis (HP:0100646) | 1.74687132 |
| 98 | Myelodysplasia (HP:0002863) | 1.74195231 |
| 99 | Aplastic anemia (HP:0001915) | 1.73924380 |
| 100 | Muscle fiber atrophy (HP:0100295) | 1.73192771 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | STK16 | 4.52568760 |
| 2 | ZAK | 4.25461131 |
| 3 | EIF2AK3 | 3.19350278 |
| 4 | VRK2 | 3.08704132 |
| 5 | FRK | 3.08508901 |
| 6 | TLK1 | 2.86652852 |
| 7 | MAP4K2 | 2.78610334 |
| 8 | PBK | 2.65565918 |
| 9 | NEK1 | 2.60734959 |
| 10 | VRK1 | 2.54410008 |
| 11 | TRIM28 | 2.53837295 |
| 12 | BUB1 | 2.49373858 |
| 13 | EIF2AK1 | 2.38177044 |
| 14 | TXK | 2.13254883 |
| 15 | NUAK1 | 2.06371258 |
| 16 | PLK3 | 2.03344347 |
| 17 | MST4 | 1.90929726 |
| 18 | TNIK | 1.86080757 |
| 19 | TSSK6 | 1.82961732 |
| 20 | CDC7 | 1.78535665 |
| 21 | BMPR1B | 1.68591259 |
| 22 | ADRBK2 | 1.67197969 |
| 23 | NLK | 1.61470956 |
| 24 | PLK4 | 1.59187124 |
| 25 | GRK1 | 1.40457504 |
| 26 | TTK | 1.35161257 |
| 27 | BRSK2 | 1.32562261 |
| 28 | MAPKAPK3 | 1.24365267 |
| 29 | MAP3K12 | 1.21296413 |
| 30 | NME1 | 1.19144691 |
| 31 | NEK2 | 1.17687242 |
| 32 | EIF2AK2 | 1.15613885 |
| 33 | TAF1 | 1.15341774 |
| 34 | PDK2 | 1.12950242 |
| 35 | TAOK3 | 1.11305444 |
| 36 | SRPK1 | 1.09842865 |
| 37 | WEE1 | 1.04614804 |
| 38 | FES | 1.02935762 |
| 39 | PASK | 1.00092433 |
| 40 | MKNK2 | 0.99300892 |
| 41 | KIT | 0.98966497 |
| 42 | OXSR1 | 0.97636162 |
| 43 | ERBB3 | 0.95675723 |
| 44 | CHEK2 | 0.88258638 |
| 45 | PLK1 | 0.87297889 |
| 46 | STK3 | 0.87230767 |
| 47 | INSRR | 0.85232782 |
| 48 | PLK2 | 0.81405612 |
| 49 | MKNK1 | 0.78411278 |
| 50 | SIK3 | 0.78147811 |
| 51 | TEC | 0.76210106 |
| 52 | AURKB | 0.74324586 |
| 53 | RPS6KA5 | 0.73077635 |
| 54 | CAMK2D | 0.71920460 |
| 55 | ACVR1B | 0.71892026 |
| 56 | ATR | 0.71331257 |
| 57 | MAP3K13 | 0.71199047 |
| 58 | ITK | 0.70592265 |
| 59 | STK4 | 0.68474419 |
| 60 | BCKDK | 0.64597482 |
| 61 | STK39 | 0.63550064 |
| 62 | CAMKK2 | 0.63283534 |
| 63 | PINK1 | 0.59365217 |
| 64 | PRKCE | 0.58425453 |
| 65 | KDR | 0.58155485 |
| 66 | DAPK1 | 0.53141228 |
| 67 | WNK3 | 0.51928019 |
| 68 | ATM | 0.48811588 |
| 69 | BRSK1 | 0.48124093 |
| 70 | CAMK1D | 0.47892056 |
| 71 | FGFR2 | 0.47663143 |
| 72 | CSNK1G1 | 0.47184509 |
| 73 | LYN | 0.43629457 |
| 74 | PRKCG | 0.42774895 |
| 75 | CSNK1G3 | 0.40217345 |
| 76 | BCR | 0.39097042 |
| 77 | CSNK2A1 | 0.38976546 |
| 78 | CLK1 | 0.37134126 |
| 79 | MYLK | 0.36521814 |
| 80 | IRAK1 | 0.33576071 |
| 81 | RPS6KB2 | 0.32616906 |
| 82 | WNK4 | 0.32540790 |
| 83 | ALK | 0.32533720 |
| 84 | PRKCB | 0.30622732 |
| 85 | CSNK1A1L | 0.30030626 |
| 86 | RPS6KB1 | 0.29342411 |
| 87 | ADRBK1 | 0.27554351 |
| 88 | CSNK2A2 | 0.27302791 |
| 89 | MAP4K1 | 0.26223686 |
| 90 | TIE1 | 0.26187642 |
| 91 | CSNK1A1 | 0.25579740 |
| 92 | FGFR1 | 0.25541905 |
| 93 | CSNK1G2 | 0.25408700 |
| 94 | PTK2B | 0.23147552 |
| 95 | CAMK2A | 0.22621892 |
| 96 | CCNB1 | 0.22565293 |
| 97 | MET | 0.22186186 |
| 98 | AURKA | 0.21989216 |
| 99 | RPS6KA4 | 0.21816373 |
| 100 | CDK7 | 0.21302161 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.83769537 |
| 2 | RNA polymerase_Homo sapiens_hsa03020 | 3.36080999 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.05717951 |
| 4 | Parkinsons disease_Homo sapiens_hsa05012 | 2.77970717 |
| 5 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.67412971 |
| 6 | Protein export_Homo sapiens_hsa03060 | 2.55830071 |
| 7 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.44655477 |
| 8 | Ribosome_Homo sapiens_hsa03010 | 2.23401878 |
| 9 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.22958737 |
| 10 | DNA replication_Homo sapiens_hsa03030 | 2.13495142 |
| 11 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.12986104 |
| 12 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.08214253 |
| 13 | Homologous recombination_Homo sapiens_hsa03440 | 2.05388006 |
| 14 | Huntingtons disease_Homo sapiens_hsa05016 | 2.04043183 |
| 15 | Phototransduction_Homo sapiens_hsa04744 | 2.02924781 |
| 16 | Alzheimers disease_Homo sapiens_hsa05010 | 1.85191177 |
| 17 | Mismatch repair_Homo sapiens_hsa03430 | 1.80569889 |
| 18 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.74977874 |
| 19 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.70202900 |
| 20 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.65143984 |
| 21 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.59638288 |
| 22 | Spliceosome_Homo sapiens_hsa03040 | 1.58785018 |
| 23 | RNA transport_Homo sapiens_hsa03013 | 1.58038673 |
| 24 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.57424418 |
| 25 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.53851592 |
| 26 | RNA degradation_Homo sapiens_hsa03018 | 1.45201135 |
| 27 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.42903264 |
| 28 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.41978599 |
| 29 | Sulfur relay system_Homo sapiens_hsa04122 | 1.40126907 |
| 30 | Basal transcription factors_Homo sapiens_hsa03022 | 1.36635460 |
| 31 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.27705888 |
| 32 | Purine metabolism_Homo sapiens_hsa00230 | 1.26136949 |
| 33 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.21911022 |
| 34 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.21044705 |
| 35 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.19691677 |
| 36 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.16819553 |
| 37 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.16392395 |
| 38 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.16063679 |
| 39 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.15909160 |
| 40 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.13755994 |
| 41 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.10835651 |
| 42 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.09388713 |
| 43 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.08785360 |
| 44 | Base excision repair_Homo sapiens_hsa03410 | 1.04371975 |
| 45 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.04053664 |
| 46 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.03723750 |
| 47 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.02727239 |
| 48 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.94679137 |
| 49 | Asthma_Homo sapiens_hsa05310 | 0.91420311 |
| 50 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.90515282 |
| 51 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.90063203 |
| 52 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.88550440 |
| 53 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.86958893 |
| 54 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.86439619 |
| 55 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.84563379 |
| 56 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.80046401 |
| 57 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.78074256 |
| 58 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.77317373 |
| 59 | Alcoholism_Homo sapiens_hsa05034 | 0.76037375 |
| 60 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.74766169 |
| 61 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.72263155 |
| 62 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.69712100 |
| 63 | Metabolic pathways_Homo sapiens_hsa01100 | 0.67623669 |
| 64 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.66147017 |
| 65 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.65620052 |
| 66 | Peroxisome_Homo sapiens_hsa04146 | 0.64848241 |
| 67 | Cell cycle_Homo sapiens_hsa04110 | 0.60699432 |
| 68 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.60127523 |
| 69 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.59979632 |
| 70 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.58552189 |
| 71 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.57207254 |
| 72 | Allograft rejection_Homo sapiens_hsa05330 | 0.56722141 |
| 73 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.56255512 |
| 74 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.55752940 |
| 75 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.55653010 |
| 76 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.54348058 |
| 77 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.51854544 |
| 78 | Carbon metabolism_Homo sapiens_hsa01200 | 0.51738656 |
| 79 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.51559206 |
| 80 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.47038908 |
| 81 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.43107796 |
| 82 | Legionellosis_Homo sapiens_hsa05134 | 0.43100540 |
| 83 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.43083761 |
| 84 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.40908688 |
| 85 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.40598595 |
| 86 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.40195878 |
| 87 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.37171234 |
| 88 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.36802359 |
| 89 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.34659664 |
| 90 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.34083531 |
| 91 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.33378397 |
| 92 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.33149590 |
| 93 | Retinol metabolism_Homo sapiens_hsa00830 | 0.32662947 |
| 94 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.31293030 |
| 95 | Taste transduction_Homo sapiens_hsa04742 | 0.29393775 |
| 96 | Olfactory transduction_Homo sapiens_hsa04740 | 0.28530628 |
| 97 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.28331537 |
| 98 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.27443051 |
| 99 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.23492208 |
| 100 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.23003169 |

