PRDX3P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)6.74642033
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.25257062
3DNA deamination (GO:0045006)4.74723144
4ATP synthesis coupled proton transport (GO:0015986)4.56828451
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.56828451
6establishment of protein localization to mitochondrial membrane (GO:0090151)4.37741588
7protein neddylation (GO:0045116)4.18040058
8DNA replication checkpoint (GO:0000076)4.10191389
9regulation of mitochondrial translation (GO:0070129)4.08831959
10transcription elongation from RNA polymerase III promoter (GO:0006385)4.08552142
11termination of RNA polymerase III transcription (GO:0006386)4.08552142
12negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.06606211
13CENP-A containing nucleosome assembly (GO:0034080)3.98860717
14platelet dense granule organization (GO:0060155)3.90675163
15chromatin remodeling at centromere (GO:0031055)3.90502337
16response to pheromone (GO:0019236)3.86839627
17positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.80299729
18mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.77172122
19organelle disassembly (GO:1903008)3.74783080
20protein complex biogenesis (GO:0070271)3.74578246
21regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.73842451
22L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.71699030
23rRNA modification (GO:0000154)3.70690698
24respiratory chain complex IV assembly (GO:0008535)3.70464550
25cytochrome complex assembly (GO:0017004)3.70239205
26negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.68814714
27negative regulation of ligase activity (GO:0051352)3.68814714
28regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.67978187
29rRNA methylation (GO:0031167)3.64845392
30regulation of cellular amino acid metabolic process (GO:0006521)3.56861251
31mitochondrial respiratory chain complex assembly (GO:0033108)3.55736808
32signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.55615006
33signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.55615006
34signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.55615006
35anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.50216276
36DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.50192130
37signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.45687709
38intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.45687709
39mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.43846802
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.43846802
41NADH dehydrogenase complex assembly (GO:0010257)3.43846802
42signal transduction involved in DNA integrity checkpoint (GO:0072401)3.43263596
43signal transduction involved in DNA damage checkpoint (GO:0072422)3.43263596
44regulation of relaxation of muscle (GO:1901077)3.42890836
45nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.41414455
46DNA double-strand break processing (GO:0000729)3.41114615
47water-soluble vitamin biosynthetic process (GO:0042364)3.40780864
48signal transduction involved in cell cycle checkpoint (GO:0072395)3.39049744
49respiratory electron transport chain (GO:0022904)3.36017841
50electron transport chain (GO:0022900)3.35834343
51ribonucleoprotein complex disassembly (GO:0032988)3.33823183
52neural tube formation (GO:0001841)3.32140181
53regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.30098216
54regulation of mitotic spindle checkpoint (GO:1903504)3.30098216
55replication fork processing (GO:0031297)3.29469830
56regulation of cell communication by electrical coupling (GO:0010649)3.28218097
57DNA ligation (GO:0006266)3.22512908
58amino acid salvage (GO:0043102)3.17699726
59L-methionine salvage (GO:0071267)3.17699726
60L-methionine biosynthetic process (GO:0071265)3.17699726
61histone exchange (GO:0043486)3.17034787
62cytidine deamination (GO:0009972)3.16015947
63cytidine metabolic process (GO:0046087)3.16015947
64cytidine catabolic process (GO:0006216)3.16015947
65kinetochore organization (GO:0051383)3.15096441
66positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.12080512
67exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.10491867
68regulation of action potential (GO:0098900)3.10243125
69RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.09398212
70tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.09398212
71negative regulation of sodium ion transport (GO:0010766)3.05452349
72histone mRNA metabolic process (GO:0008334)3.02364623
73lactate metabolic process (GO:0006089)3.02318169
74mannosylation (GO:0097502)3.02169972
75DNA replication-dependent nucleosome organization (GO:0034723)3.01789437
76DNA replication-dependent nucleosome assembly (GO:0006335)3.01789437
77negative regulation of DNA-dependent DNA replication (GO:2000104)3.00744494
78viral mRNA export from host cell nucleus (GO:0046784)3.00154753
79kinetochore assembly (GO:0051382)2.96327481
80positive regulation of ligase activity (GO:0051351)2.95071413
81preassembly of GPI anchor in ER membrane (GO:0016254)2.92081774
82inner mitochondrial membrane organization (GO:0007007)2.90235462
83GPI anchor biosynthetic process (GO:0006506)2.89413444
84GPI anchor metabolic process (GO:0006505)2.89248601
85DNA replication-independent nucleosome organization (GO:0034724)2.88595583
86DNA replication-independent nucleosome assembly (GO:0006336)2.88595583
87IMP biosynthetic process (GO:0006188)2.87425214
88pyrimidine ribonucleoside catabolic process (GO:0046133)2.86674918
89transcription from RNA polymerase III promoter (GO:0006383)2.83000094
90ribosome biogenesis (GO:0042254)2.81122736
91signal peptide processing (GO:0006465)2.80421022
92hepatocyte apoptotic process (GO:0097284)2.78663079
93ATP biosynthetic process (GO:0006754)2.78168937
94DNA catabolic process, exonucleolytic (GO:0000738)2.75173915
95pseudouridine synthesis (GO:0001522)2.75086835
96ribosome assembly (GO:0042255)2.73844789
97chaperone-mediated protein transport (GO:0072321)2.73666535
98DNA-templated transcription, termination (GO:0006353)2.72856813
99artery smooth muscle contraction (GO:0014824)2.71644051
100C-terminal protein lipidation (GO:0006501)2.70983492

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.20486183
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.70746601
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.53443142
4E2F7_22180533_ChIP-Seq_HELA_Human4.24168623
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.77931404
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.51283232
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.09304485
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.92225480
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.91228653
10ELK1_19687146_ChIP-ChIP_HELA_Human2.84367852
11VDR_23849224_ChIP-Seq_CD4+_Human2.71603872
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.66899137
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.61277462
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.55565572
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.55405196
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.52608816
17VDR_22108803_ChIP-Seq_LS180_Human2.51102879
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.34269184
19FOXP3_21729870_ChIP-Seq_TREG_Human2.32542935
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.30448865
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.27799862
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.20724963
23ZNF274_21170338_ChIP-Seq_K562_Hela2.18585711
24PADI4_21655091_ChIP-ChIP_MCF-7_Human2.03848990
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92731312
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.85652095
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.79800426
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.77656140
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.74642533
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74389470
31MYC_19030024_ChIP-ChIP_MESCs_Mouse1.73301101
32DCP1A_22483619_ChIP-Seq_HELA_Human1.71746386
33MYC_18940864_ChIP-ChIP_HL60_Human1.65653081
34MYC_18358816_ChIP-ChIP_MESCs_Mouse1.65614204
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.60477302
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55772524
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53707471
38EWS_26573619_Chip-Seq_HEK293_Human1.53009614
39TTF2_22483619_ChIP-Seq_HELA_Human1.50334136
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49816418
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.46694314
42PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.44941990
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42858188
44HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.42062796
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35515645
46FUS_26573619_Chip-Seq_HEK293_Human1.31428134
47EGR1_23403033_ChIP-Seq_LIVER_Mouse1.31035813
48GABP_19822575_ChIP-Seq_HepG2_Human1.30952275
49TP53_22573176_ChIP-Seq_HFKS_Human1.28693128
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27582457
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26645927
52NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24941876
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23041816
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.22085555
55P300_19829295_ChIP-Seq_ESCs_Human1.21942713
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.21815550
57AR_21909140_ChIP-Seq_LNCAP_Human1.21792253
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.20361959
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19030909
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.17843969
61NANOG_16153702_ChIP-ChIP_HESCs_Human1.12991086
62FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12967734
63IGF1R_20145208_ChIP-Seq_DFB_Human1.12900921
64IRF1_19129219_ChIP-ChIP_H3396_Human1.12726110
65ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12410323
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.11827965
67FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11827965
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11769232
69EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.10981765
70MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09030197
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05528482
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05083733
73IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.04391844
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03921407
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03134126
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01152064
77XRN2_22483619_ChIP-Seq_HELA_Human1.00496818
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99921540
79ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99635615
80NFE2_27457419_Chip-Seq_LIVER_Mouse0.97368975
81KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.96990233
82AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96323939
83ELK1_22589737_ChIP-Seq_MCF10A_Human0.94396445
84PHF8_20622853_ChIP-Seq_HELA_Human0.93969189
85CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93287076
86SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93271462
87TAF15_26573619_Chip-Seq_HEK293_Human0.93042036
88AR_20517297_ChIP-Seq_VCAP_Human0.92711491
89ER_23166858_ChIP-Seq_MCF-7_Human0.91106812
90RBPJ_21746931_ChIP-Seq_IB4_Human0.90888489
91PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.89519775
92CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89260598
93NANOG_19829295_ChIP-Seq_ESCs_Human0.88847966
94SOX2_19829295_ChIP-Seq_ESCs_Human0.88847966
95GATA6_21074721_ChIP-Seq_CACO-2_Human0.88462442
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88068502
97SOX2_16153702_ChIP-ChIP_HESCs_Human0.87326185
98EZH2_27294783_Chip-Seq_NPCs_Mouse0.86646085
99CDX2_22108803_ChIP-Seq_LS180_Human0.86298061
100CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.83017389

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis5.08571515
2MP0006054_spinal_hemorrhage4.46395625
3MP0009697_abnormal_copulation4.01766374
4MP0002254_reproductive_system_inflammat3.77256896
5MP0010094_abnormal_chromosome_stability3.22395740
6MP0002102_abnormal_ear_morphology2.91933093
7MP0000372_irregular_coat_pigmentation2.77650673
8MP0008058_abnormal_DNA_repair2.74984892
9MP0003786_premature_aging2.39696137
10MP0003195_calcinosis2.34984994
11MP0006072_abnormal_retinal_apoptosis2.29781990
12MP0002396_abnormal_hematopoietic_system2.28385645
13MP0003136_yellow_coat_color2.20044136
14MP0003111_abnormal_nucleus_morphology2.17748992
15MP0002928_abnormal_bile_duct2.02319638
16MP0005084_abnormal_gallbladder_morpholo2.00284015
17MP0003252_abnormal_bile_duct1.96893102
18MP0002837_dystrophic_cardiac_calcinosis1.90495997
19MP0005075_abnormal_melanosome_morpholog1.88960585
20MP0001984_abnormal_olfaction1.81765187
21MP0005671_abnormal_response_to1.80912736
22MP0003718_maternal_effect1.77285884
23MP0001529_abnormal_vocalization1.76018274
24MP0005253_abnormal_eye_physiology1.68983265
25MP0003693_abnormal_embryo_hatching1.68942365
26MP0003221_abnormal_cardiomyocyte_apopto1.61212294
27MP0008995_early_reproductive_senescence1.58523847
28MP0005551_abnormal_eye_electrophysiolog1.56344219
29MP0002166_altered_tumor_susceptibility1.54015373
30MP0008932_abnormal_embryonic_tissue1.53173402
31MP0003880_abnormal_central_pattern1.52632719
32MP0004957_abnormal_blastocyst_morpholog1.48369708
33MP0003077_abnormal_cell_cycle1.47842739
34MP0006036_abnormal_mitochondrial_physio1.47718201
35MP0005645_abnormal_hypothalamus_physiol1.44802540
36MP0005379_endocrine/exocrine_gland_phen1.44588613
37MP0008872_abnormal_physiological_respon1.43929923
38MP0008007_abnormal_cellular_replicative1.43076655
39MP0005360_urolithiasis1.33271679
40MP0010352_gastrointestinal_tract_polyps1.30735029
41MP0002938_white_spotting1.28077095
42MP0001764_abnormal_homeostasis1.21711405
43MP0005187_abnormal_penis_morphology1.20846614
44MP0004215_abnormal_myocardial_fiber1.19759471
45MP0006035_abnormal_mitochondrial_morpho1.18526805
46MP0002006_tumorigenesis1.16558583
47MP0002090_abnormal_vision1.14841522
48MP0001485_abnormal_pinna_reflex1.09109691
49MP0001919_abnormal_reproductive_system1.06814151
50MP0001929_abnormal_gametogenesis1.06239809
51MP0002736_abnormal_nociception_after1.05235906
52MP0002163_abnormal_gland_morphology1.05138783
53MP0003186_abnormal_redox_activity1.04834888
54MP0005389_reproductive_system_phenotype1.04675962
55MP0008877_abnormal_DNA_methylation1.01516538
56MP0003011_delayed_dark_adaptation1.01137815
57MP0005410_abnormal_fertilization0.97873969
58MP0008789_abnormal_olfactory_epithelium0.97109799
59MP0008057_abnormal_DNA_replication0.95752961
60MP0000653_abnormal_sex_gland0.95718724
61MP0002210_abnormal_sex_determination0.95330593
62MP0002160_abnormal_reproductive_system0.94723354
63MP0003119_abnormal_digestive_system0.94171140
64MP0005636_abnormal_mineral_homeostasis0.92315325
65MP0005395_other_phenotype0.91545327
66MP0005174_abnormal_tail_pigmentation0.87548711
67MP0004484_altered_response_of0.86974591
68MP0002751_abnormal_autonomic_nervous0.85997573
69MP0003937_abnormal_limbs/digits/tail_de0.85832928
70MP0005332_abnormal_amino_acid0.85305090
71MP0000569_abnormal_digit_pigmentation0.84945888
72MP0004019_abnormal_vitamin_homeostasis0.84711815
73MP0003698_abnormal_male_reproductive0.84513033
74MP0004147_increased_porphyrin_level0.84412917
75MP0001835_abnormal_antigen_presentation0.83632097
76MP0004084_abnormal_cardiac_muscle0.83250811
77MP0005310_abnormal_salivary_gland0.82398939
78MP0001119_abnormal_female_reproductive0.81179261
79MP0001661_extended_life_span0.81151619
80MP0001293_anophthalmia0.79545668
81MP0001145_abnormal_male_reproductive0.79269676
82MP0001968_abnormal_touch/_nociception0.78249663
83MP0005391_vision/eye_phenotype0.78001751
84MP0001756_abnormal_urination0.76873974
85MP0005319_abnormal_enzyme/_coenzyme0.74380509
86MP0005376_homeostasis/metabolism_phenot0.72415115
87MP0002095_abnormal_skin_pigmentation0.72158050
88MP0000383_abnormal_hair_follicle0.71731043
89MP0008875_abnormal_xenobiotic_pharmacok0.70477562
90MP0004381_abnormal_hair_follicle0.63771514
91MP0005195_abnormal_posterior_eye0.63723803
92MP0002138_abnormal_hepatobiliary_system0.63144590
93MP0001666_abnormal_nutrient_absorption0.61532662
94MP0005220_abnormal_exocrine_pancreas0.61498542
95MP0002909_abnormal_adrenal_gland0.60884340
96MP0005167_abnormal_blood-brain_barrier0.59638351
97MP0005365_abnormal_bile_salt0.59075497
98MP0005266_abnormal_metabolism0.58734471
99MP0010307_abnormal_tumor_latency0.58720970
100MP0000358_abnormal_cell_content/0.55431688

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.83732878
2Acute encephalopathy (HP:0006846)4.41796871
3Mitochondrial inheritance (HP:0001427)4.31666763
4Progressive macrocephaly (HP:0004481)4.12460693
5Abnormal mitochondria in muscle tissue (HP:0008316)4.06609546
6Increased CSF lactate (HP:0002490)4.01016796
7Congenital, generalized hypertrichosis (HP:0004540)3.86475068
8Hepatocellular necrosis (HP:0001404)3.76558163
9Hepatic necrosis (HP:0002605)3.34704289
10Increased hepatocellular lipid droplets (HP:0006565)3.27608273
11Meckel diverticulum (HP:0002245)3.20895669
12Lipid accumulation in hepatocytes (HP:0006561)3.19782942
13Cerebral edema (HP:0002181)3.16772533
143-Methylglutaconic aciduria (HP:0003535)3.10701815
15Methylmalonic aciduria (HP:0012120)3.07517713
16Abnormality of the ileum (HP:0001549)3.06938294
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.06798470
18Aplasia/Hypoplasia of the uvula (HP:0010293)3.03878631
19Abnormality of chromosome stability (HP:0003220)2.94757211
20Pancreatic cysts (HP:0001737)2.91772898
21Cerebral hypomyelination (HP:0006808)2.82406264
22Increased serum lactate (HP:0002151)2.73971888
23Chromsome breakage (HP:0040012)2.67555613
24Abnormal number of erythroid precursors (HP:0012131)2.63432025
25Abnormality of the preputium (HP:0100587)2.63288889
26Increased serum pyruvate (HP:0003542)2.60524072
27Lactic acidosis (HP:0003128)2.60436554
28Optic disc pallor (HP:0000543)2.59955472
29Methylmalonic acidemia (HP:0002912)2.59105504
30Abnormality of methionine metabolism (HP:0010901)2.50713928
31Hyperinsulinemic hypoglycemia (HP:0000825)2.46541524
32Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.46424148
33Type I transferrin isoform profile (HP:0003642)2.46081903
34Pancreatic fibrosis (HP:0100732)2.44374686
35Chronic diarrhea (HP:0002028)2.42673750
36Clubbing of toes (HP:0100760)2.40976866
37Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.40648589
38Respiratory failure (HP:0002878)2.39987145
39Lethargy (HP:0001254)2.38294028
40Hyperglycinemia (HP:0002154)2.34802502
41Congenital stationary night blindness (HP:0007642)2.34471858
42Absent thumb (HP:0009777)2.34372339
43Leukodystrophy (HP:0002415)2.33009940
44Posterior subcapsular cataract (HP:0007787)2.29997898
45True hermaphroditism (HP:0010459)2.29537297
46Molar tooth sign on MRI (HP:0002419)2.27628234
47Abnormality of midbrain morphology (HP:0002418)2.27628234
48Respiratory difficulties (HP:0002880)2.25504265
49Hypoglycemic coma (HP:0001325)2.25289844
50Duodenal stenosis (HP:0100867)2.24314957
51Small intestinal stenosis (HP:0012848)2.24314957
52Renal Fanconi syndrome (HP:0001994)2.24238046
53Hypoplasia of the pons (HP:0012110)2.22701861
54Triphalangeal thumb (HP:0001199)2.21931982
55Abnormality of glycolysis (HP:0004366)2.18917356
56Abnormality of T cell physiology (HP:0011840)2.18206258
57Renal cortical cysts (HP:0000803)2.18127598
58Abnormality of aspartate family amino acid metabolism (HP:0010899)2.15954557
59Hypoproteinemia (HP:0003075)2.15804992
60Amelogenesis imperfecta (HP:0000705)2.14850609
61Type 2 muscle fiber atrophy (HP:0003554)2.13908720
62Aplasia/Hypoplasia of the fovea (HP:0008060)2.11478546
63Hypoplasia of the fovea (HP:0007750)2.11478546
64Constricted visual fields (HP:0001133)2.07447580
65Abnormality of cells of the erythroid lineage (HP:0012130)2.06883572
66Abnormality of alanine metabolism (HP:0010916)2.06098562
67Hyperalaninemia (HP:0003348)2.06098562
68Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.06098562
69Abnormality of serum amino acid levels (HP:0003112)2.04820718
70Hypoglycemic seizures (HP:0002173)2.04251304
71Abnormality of the duodenum (HP:0002246)2.03801427
72Abnormality of the pons (HP:0007361)2.03432828
73Exertional dyspnea (HP:0002875)2.01459321
74Colon cancer (HP:0003003)1.97745059
75Microvesicular hepatic steatosis (HP:0001414)1.97743952
76Nephronophthisis (HP:0000090)1.96933281
77Amniotic constriction ring (HP:0009775)1.96778612
78Abnormality of placental membranes (HP:0011409)1.96778612
79Symptomatic seizures (HP:0011145)1.94917768
80CNS demyelination (HP:0007305)1.92564193
81Sloping forehead (HP:0000340)1.90687633
82Abnormal protein N-linked glycosylation (HP:0012347)1.88106326
83Abnormal protein glycosylation (HP:0012346)1.88106326
84Abnormal glycosylation (HP:0012345)1.88106326
85Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.88106326
86Reticulocytopenia (HP:0001896)1.86636631
87Exercise intolerance (HP:0003546)1.86344620
88Pancreatic islet-cell hyperplasia (HP:0004510)1.84070572
89Abnormality of the fovea (HP:0000493)1.83754686
90Abnormality of the labia minora (HP:0012880)1.83344287
91Duplicated collecting system (HP:0000081)1.82832744
92Abolished electroretinogram (ERG) (HP:0000550)1.77781209
93Attenuation of retinal blood vessels (HP:0007843)1.75969013
94Prolonged partial thromboplastin time (HP:0003645)1.75867029
95CNS hypomyelination (HP:0003429)1.74860255
96Hyperglycinuria (HP:0003108)1.74783171
97Thyroiditis (HP:0100646)1.74687132
98Myelodysplasia (HP:0002863)1.74195231
99Aplastic anemia (HP:0001915)1.73924380
100Muscle fiber atrophy (HP:0100295)1.73192771

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.52568760
2ZAK4.25461131
3EIF2AK33.19350278
4VRK23.08704132
5FRK3.08508901
6TLK12.86652852
7MAP4K22.78610334
8PBK2.65565918
9NEK12.60734959
10VRK12.54410008
11TRIM282.53837295
12BUB12.49373858
13EIF2AK12.38177044
14TXK2.13254883
15NUAK12.06371258
16PLK32.03344347
17MST41.90929726
18TNIK1.86080757
19TSSK61.82961732
20CDC71.78535665
21BMPR1B1.68591259
22ADRBK21.67197969
23NLK1.61470956
24PLK41.59187124
25GRK11.40457504
26TTK1.35161257
27BRSK21.32562261
28MAPKAPK31.24365267
29MAP3K121.21296413
30NME11.19144691
31NEK21.17687242
32EIF2AK21.15613885
33TAF11.15341774
34PDK21.12950242
35TAOK31.11305444
36SRPK11.09842865
37WEE11.04614804
38FES1.02935762
39PASK1.00092433
40MKNK20.99300892
41KIT0.98966497
42OXSR10.97636162
43ERBB30.95675723
44CHEK20.88258638
45PLK10.87297889
46STK30.87230767
47INSRR0.85232782
48PLK20.81405612
49MKNK10.78411278
50SIK30.78147811
51TEC0.76210106
52AURKB0.74324586
53RPS6KA50.73077635
54CAMK2D0.71920460
55ACVR1B0.71892026
56ATR0.71331257
57MAP3K130.71199047
58ITK0.70592265
59STK40.68474419
60BCKDK0.64597482
61STK390.63550064
62CAMKK20.63283534
63PINK10.59365217
64PRKCE0.58425453
65KDR0.58155485
66DAPK10.53141228
67WNK30.51928019
68ATM0.48811588
69BRSK10.48124093
70CAMK1D0.47892056
71FGFR20.47663143
72CSNK1G10.47184509
73LYN0.43629457
74PRKCG0.42774895
75CSNK1G30.40217345
76BCR0.39097042
77CSNK2A10.38976546
78CLK10.37134126
79MYLK0.36521814
80IRAK10.33576071
81RPS6KB20.32616906
82WNK40.32540790
83ALK0.32533720
84PRKCB0.30622732
85CSNK1A1L0.30030626
86RPS6KB10.29342411
87ADRBK10.27554351
88CSNK2A20.27302791
89MAP4K10.26223686
90TIE10.26187642
91CSNK1A10.25579740
92FGFR10.25541905
93CSNK1G20.25408700
94PTK2B0.23147552
95CAMK2A0.22621892
96CCNB10.22565293
97MET0.22186186
98AURKA0.21989216
99RPS6KA40.21816373
100CDK70.21302161

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.83769537
2RNA polymerase_Homo sapiens_hsa030203.36080999
3Oxidative phosphorylation_Homo sapiens_hsa001903.05717951
4Parkinsons disease_Homo sapiens_hsa050122.77970717
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.67412971
6Protein export_Homo sapiens_hsa030602.55830071
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.44655477
8Ribosome_Homo sapiens_hsa030102.23401878
9Propanoate metabolism_Homo sapiens_hsa006402.22958737
10DNA replication_Homo sapiens_hsa030302.13495142
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.12986104
12Fanconi anemia pathway_Homo sapiens_hsa034602.08214253
13Homologous recombination_Homo sapiens_hsa034402.05388006
14Huntingtons disease_Homo sapiens_hsa050162.04043183
15Phototransduction_Homo sapiens_hsa047442.02924781
16Alzheimers disease_Homo sapiens_hsa050101.85191177
17Mismatch repair_Homo sapiens_hsa034301.80569889
18Non-homologous end-joining_Homo sapiens_hsa034501.74977874
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.70202900
20Nitrogen metabolism_Homo sapiens_hsa009101.65143984
21One carbon pool by folate_Homo sapiens_hsa006701.59638288
22Spliceosome_Homo sapiens_hsa030401.58785018
23RNA transport_Homo sapiens_hsa030131.58038673
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.57424418
25Pyrimidine metabolism_Homo sapiens_hsa002401.53851592
26RNA degradation_Homo sapiens_hsa030181.45201135
27Folate biosynthesis_Homo sapiens_hsa007901.42903264
28Systemic lupus erythematosus_Homo sapiens_hsa053221.41978599
29Sulfur relay system_Homo sapiens_hsa041221.40126907
30Basal transcription factors_Homo sapiens_hsa030221.36635460
31Nucleotide excision repair_Homo sapiens_hsa034201.27705888
32Purine metabolism_Homo sapiens_hsa002301.26136949
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21911022
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.21044705
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.19691677
36Linoleic acid metabolism_Homo sapiens_hsa005911.16819553
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16392395
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16063679
39Fatty acid elongation_Homo sapiens_hsa000621.15909160
40Butanoate metabolism_Homo sapiens_hsa006501.13755994
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10835651
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09388713
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.08785360
44Base excision repair_Homo sapiens_hsa034101.04371975
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04053664
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.03723750
47Pyruvate metabolism_Homo sapiens_hsa006201.02727239
48Cardiac muscle contraction_Homo sapiens_hsa042600.94679137
49Asthma_Homo sapiens_hsa053100.91420311
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90515282
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90063203
52Antigen processing and presentation_Homo sapiens_hsa046120.88550440
53Fat digestion and absorption_Homo sapiens_hsa049750.86958893
54Tryptophan metabolism_Homo sapiens_hsa003800.86439619
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84563379
56Graft-versus-host disease_Homo sapiens_hsa053320.80046401
57Vitamin B6 metabolism_Homo sapiens_hsa007500.78074256
58Glutathione metabolism_Homo sapiens_hsa004800.77317373
59Alcoholism_Homo sapiens_hsa050340.76037375
60Steroid biosynthesis_Homo sapiens_hsa001000.74766169
61Ether lipid metabolism_Homo sapiens_hsa005650.72263155
62Autoimmune thyroid disease_Homo sapiens_hsa053200.69712100
63Metabolic pathways_Homo sapiens_hsa011000.67623669
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.66147017
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65620052
66Peroxisome_Homo sapiens_hsa041460.64848241
67Cell cycle_Homo sapiens_hsa041100.60699432
68Oocyte meiosis_Homo sapiens_hsa041140.60127523
69Selenocompound metabolism_Homo sapiens_hsa004500.59979632
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58552189
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57207254
72Allograft rejection_Homo sapiens_hsa053300.56722141
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56255512
74mRNA surveillance pathway_Homo sapiens_hsa030150.55752940
75Chemical carcinogenesis_Homo sapiens_hsa052040.55653010
76Primary immunodeficiency_Homo sapiens_hsa053400.54348058
77p53 signaling pathway_Homo sapiens_hsa041150.51854544
78Carbon metabolism_Homo sapiens_hsa012000.51738656
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51559206
80TGF-beta signaling pathway_Homo sapiens_hsa043500.47038908
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.43107796
82Legionellosis_Homo sapiens_hsa051340.43100540
83Caffeine metabolism_Homo sapiens_hsa002320.43083761
84N-Glycan biosynthesis_Homo sapiens_hsa005100.40908688
85Type I diabetes mellitus_Homo sapiens_hsa049400.40598595
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40195878
87Vitamin digestion and absorption_Homo sapiens_hsa049770.37171234
88Fatty acid metabolism_Homo sapiens_hsa012120.36802359
89Fatty acid degradation_Homo sapiens_hsa000710.34659664
90Sulfur metabolism_Homo sapiens_hsa009200.34083531
91Serotonergic synapse_Homo sapiens_hsa047260.33378397
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33149590
93Retinol metabolism_Homo sapiens_hsa008300.32662947
94Regulation of autophagy_Homo sapiens_hsa041400.31293030
95Taste transduction_Homo sapiens_hsa047420.29393775
96Olfactory transduction_Homo sapiens_hsa047400.28530628
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28331537
98Biosynthesis of amino acids_Homo sapiens_hsa012300.27443051
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23492208
100Rheumatoid arthritis_Homo sapiens_hsa053230.23003169

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