ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	epithelial cilium movement (GO:0003351)	9.91908719
2	ventricular system development (GO:0021591)	7.69010898
3	regulation of cilium movement (GO:0003352)	6.65968112
4	photoreceptor cell maintenance (GO:0045494)	6.12811529
5	microtubule bundle formation (GO:0001578)	5.72100803
6	left/right pattern formation (GO:0060972)	5.62497096
7	eye photoreceptor cell development (GO:0042462)	5.14640866
8	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)	4.95641415
9	photoreceptor cell development (GO:0042461)	4.93642717
10	left/right axis specification (GO:0070986)	4.67949093
11	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	4.43123509
12	cilium organization (GO:0044782)	4.19995919
13	regulation of DNA endoreduplication (GO:0032875)	4.04461395
14	lateral ventricle development (GO:0021670)	4.01475364
15	regulation of microtubule-based movement (GO:0060632)	3.97849643
16	hepatocyte differentiation (GO:0070365)	3.94894481
17	microtubule-based movement (GO:0007018)	3.83561552
18	interkinetic nuclear migration (GO:0022027)	3.77189881
19	peristalsis (GO:0030432)	3.72356907
20	oxidative demethylation (GO:0070989)	3.64464690
21	metanephric mesenchyme development (GO:0072075)	3.61786853
22	iron ion import (GO:0097286)	3.61671645
23	brain morphogenesis (GO:0048854)	3.56698400
24	cilium morphogenesis (GO:0060271)	3.55433677
25	cellular component assembly involved in morphogenesis (GO:0010927)	3.53656658
26	pericardium development (GO:0060039)	3.53173714
27	intraciliary transport (GO:0042073)	3.39427381
28	axis elongation (GO:0003401)	3.39127981
29	cilium assembly (GO:0042384)	3.34605978
30	negative regulation of complement activation (GO:0045916)	3.16216860
31	multicellular organismal aging (GO:0010259)	3.13252127
32	microtubule depolymerization (GO:0007019)	3.09886995
33	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.05178212
34	regulation of translation, ncRNA-mediated (GO:0045974)	3.05178212
35	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.05178212
36	kidney mesenchyme development (GO:0072074)	3.04096652
37	kidney morphogenesis (GO:0060993)	3.03425413
38	urinary tract smooth muscle contraction (GO:0014848)	3.02720752
39	fat-soluble vitamin biosynthetic process (GO:0042362)	3.01192891
40	regulation of interleukin-5 production (GO:0032674)	2.98054452
41	regulation of pigment cell differentiation (GO:0050932)	2.88877809
42	nucleus localization (GO:0051647)	2.88731773
43	negative regulation of protein activation cascade (GO:2000258)	2.88669449
44	protein localization to cilium (GO:0061512)	2.80721262
45	protein localization to microtubule cytoskeleton (GO:0072698)	2.78400593
46	determination of left/right symmetry (GO:0007368)	2.73461284
47	determination of bilateral symmetry (GO:0009855)	2.72687051
48	drug catabolic process (GO:0042737)	2.71401829
49	cell projection assembly (GO:0030031)	2.70606752
50	snRNA transcription (GO:0009301)	2.70318447
51	specification of symmetry (GO:0009799)	2.67745214
52	positive regulation of urine volume (GO:0035810)	2.61979991
53	regulation of transforming growth factor beta1 production (GO:0032908)	2.61845297
54	indole-containing compound catabolic process (GO:0042436)	2.59925688
55	indolalkylamine catabolic process (GO:0046218)	2.59925688
56	tryptophan catabolic process (GO:0006569)	2.59925688
57	maintenance of gastrointestinal epithelium (GO:0030277)	2.57638737
58	O-glycan processing (GO:0016266)	2.55743822
59	lung lobe morphogenesis (GO:0060463)	2.55610469
60	smooth muscle tissue development (GO:0048745)	2.54537450
61	lateral sprouting from an epithelium (GO:0060601)	2.52444457
62	protein localization to cytoskeleton (GO:0044380)	2.48204004
63	exogenous drug catabolic process (GO:0042738)	2.46216900
64	ubiquinone biosynthetic process (GO:0006744)	2.45402107
65	establishment of protein localization to Golgi (GO:0072600)	2.45383364
66	lung vasculature development (GO:0060426)	2.44453507
67	multicellular organismal reproductive behavior (GO:0033057)	2.44230171
68	synaptic vesicle docking involved in exocytosis (GO:0016081)	2.42589755
69	trophoblast giant cell differentiation (GO:0060707)	2.39859011
70	positive regulation of developmental pigmentation (GO:0048087)	2.39526367
71	kynurenine metabolic process (GO:0070189)	2.39101006
72	early endosome to late endosome transport (GO:0045022)	2.39017158
73	regulation of establishment of planar polarity (GO:0090175)	2.37019744
74	negative regulation of humoral immune response (GO:0002921)	2.36730624
75	microtubule severing (GO:0051013)	2.35913345
76	blastocyst development (GO:0001824)	2.34823480
77	regulation of p38MAPK cascade (GO:1900744)	2.33763149
78	tryptophan metabolic process (GO:0006568)	2.32094556
79	regulation of phospholipase A2 activity (GO:0032429)	2.30668011
80	microtubule-based process (GO:0007017)	2.29287199
81	phasic smooth muscle contraction (GO:0014821)	2.27880444
82	regulation of smooth muscle cell differentiation (GO:0051150)	2.24459730
83	protein O-linked glycosylation (GO:0006493)	2.20946601
84	lung development (GO:0030324)	2.20420111
85	Wnt signaling pathway, planar cell polarity pathway (GO:0060071)	2.20140428
86	parturition (GO:0007567)	2.19505263
87	genitalia morphogenesis (GO:0035112)	2.18369601
88	microtubule polymerization or depolymerization (GO:0031109)	2.17350378
89	regulation of integrin-mediated signaling pathway (GO:2001044)	2.15961477
90	embryonic retina morphogenesis in camera-type eye (GO:0060059)	2.13362674
91	ovulation from ovarian follicle (GO:0001542)	2.13337509
92	embryonic cranial skeleton morphogenesis (GO:0048701)	2.12061142
93	cilium or flagellum-dependent cell motility (GO:0001539)	18.2406219
94	retinal rod cell development (GO:0046548)	15.6924966
95	retinal cone cell development (GO:0046549)	15.1761198
96	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	14.5455507
97	cilium movement (GO:0003341)	12.7635192
98	axoneme assembly (GO:0035082)	12.6005909
99	motile cilium assembly (GO:0044458)	11.8558909
100	axonemal dynein complex assembly (GO:0070286)	11.3325423

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	7.42569083
2	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	4.50772309
3	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.87924404
4	AR_21572438_ChIP-Seq_LNCaP_Human	3.79094235
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.92587783
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.86445682
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.77145342
8	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.74026964
9	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.51737575
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.46964800
11	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.18341910
12	ZNF217_24962896_ChIP-Seq_MCF-7_Human	2.13459849
13	SMAD4_21799915_ChIP-Seq_A2780_Human	2.09329592
14	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.04717999
15	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.93896513
16	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.93039703
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.91704041
18	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.86823984
19	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.85932911
20	GATA1_22025678_ChIP-Seq_K562_Human	1.85920487
21	TP53_16413492_ChIP-PET_HCT116_Human	1.83635204
22	STAT3_23295773_ChIP-Seq_U87_Human	1.76692115
23	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.76463769
24	AHR_22903824_ChIP-Seq_MCF-7_Human	1.75165867
25	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.71327148
26	TAF15_26573619_Chip-Seq_HEK293_Human	1.68069321
27	CBP_20019798_ChIP-Seq_JUKART_Human	1.67912514
28	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.67912514
29	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.67695585
30	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.65890686
31	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.65462574
32	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.62012798
33	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.59577039
34	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.58196615
35	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.57522729
36	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.53472567
37	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.52559412
38	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.52246295
39	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.51754147
40	P300_19829295_ChIP-Seq_ESCs_Human	1.47372102
41	CJUN_26792858_Chip-Seq_BT549_Human	1.46836807
42	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.45253304
43	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.43883232
44	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.42964156
45	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.42795854
46	TP53_18474530_ChIP-ChIP_U2OS_Human	1.39836025
47	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.38738963
48	FUS_26573619_Chip-Seq_HEK293_Human	1.38738406
49	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.36234861
50	TCF4_23295773_ChIP-Seq_U87_Human	1.34249173
51	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.32866245
52	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.31334235
53	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.31193437
54	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.30417368
55	EWS_26573619_Chip-Seq_HEK293_Human	1.29753965
56	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.29744708
57	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.29744708
58	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.29143913
59	BCAT_22108803_ChIP-Seq_LS180_Human	1.27477121
60	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.26676529
61	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.25435105
62	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24689533
63	P53_22387025_ChIP-Seq_ESCs_Mouse	1.22522517
64	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.22414186
65	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.20671539
66	KDM2B_26808549_Chip-Seq_REH_Human	1.19918398
67	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.19825228
68	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.19439817
69	ER_23166858_ChIP-Seq_MCF-7_Human	1.19050146
70	VDR_22108803_ChIP-Seq_LS180_Human	1.18162195
71	AR_25329375_ChIP-Seq_VCAP_Human	1.17708974
72	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.13833043
73	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.13567647
74	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.12332731
75	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.12248474
76	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.11573659
77	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.11053605
78	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.09950967
79	CDX2_22108803_ChIP-Seq_LS180_Human	1.09449470
80	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.08123709
81	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.07560818
82	RUNX2_22187159_ChIP-Seq_PCA_Human	1.06023927
83	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.03314707
84	TP63_23658742_ChIP-Seq_EP156T_Human	1.02193505
85	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.00857499
86	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.99790230
87	TCF4_22108803_ChIP-Seq_LS180_Human	0.99628270
88	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.99391329
89	DROSHA_22980978_ChIP-Seq_HELA_Human	0.99257334
90	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.98839811
91	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.98807436
92	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.94922864
93	TBL1_22424771_ChIP-Seq_293T_Human	0.93953448
94	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.92299954
95	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.91373992
96	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.91319228
97	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.91311121
98	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.89955783
99	SOX2_19829295_ChIP-Seq_ESCs_Human	0.89314325
100	NANOG_19829295_ChIP-Seq_ESCs_Human	0.89314325

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002653_abnormal_ependyma_morphology	4.48090538
2	MP0005623_abnormal_meninges_morphology	4.09097388
3	MP0005253_abnormal_eye_physiology	3.51503672
4	MP0001346_abnormal_lacrimal_gland	3.46768512
5	MP0003950_abnormal_plasma_membrane	3.21411704
6	MP0010368_abnormal_lymphatic_system	3.01526717
7	MP0005551_abnormal_eye_electrophysiolog	2.96917074
8	MP0008057_abnormal_DNA_replication	2.69567281
9	MP0000383_abnormal_hair_follicle	2.51698024
10	MP0004272_abnormal_basement_membrane	2.47260458
11	MP0001661_extended_life_span	2.46264254
12	MP0001958_emphysema	2.29603873
13	MP0010386_abnormal_urinary_bladder	2.29592901
14	MP0005083_abnormal_biliary_tract	2.27244372
15	MP0008438_abnormal_cutaneous_collagen	2.22238021
16	MP0005248_abnormal_Harderian_gland	2.19301309
17	MP0005503_abnormal_tendon_morphology	2.18914458
18	MP0004043_abnormal_pH_regulation	2.15856356
19	MP0005275_abnormal_skin_tensile	2.14981198
20	MP0005360_urolithiasis	2.09498847
21	MP0003045_fibrosis	2.01867864
22	MP0005085_abnormal_gallbladder_physiolo	2.01863244
23	MP0006054_spinal_hemorrhage	1.94243219
24	MP0010030_abnormal_orbit_morphology	1.92528948
25	MP0002168_other_aberrant_phenotype	1.88131163
26	MP0004145_abnormal_muscle_electrophysio	1.87358253
27	MP0003195_calcinosis	1.82143014
28	MP0005195_abnormal_posterior_eye	1.78487106
29	MP0000569_abnormal_digit_pigmentation	1.73430218
30	MP0010678_abnormal_skin_adnexa	1.72263829
31	MP0003868_abnormal_feces_composition	1.68601681
32	MP0010352_gastrointestinal_tract_polyps	1.66802179
33	MP0005377_hearing/vestibular/ear_phenot	1.63849813
34	MP0003878_abnormal_ear_physiology	1.63849813
35	MP0008875_abnormal_xenobiotic_pharmacok	1.62280237
36	MP0009780_abnormal_chondrocyte_physiolo	1.61837547
37	MP0001851_eye_inflammation	1.59552777
38	MP0002282_abnormal_trachea_morphology	1.55689486
39	MP0002160_abnormal_reproductive_system	1.53074906
40	MP0005391_vision/eye_phenotype	1.51035234
41	MP0003941_abnormal_skin_development	1.46578996
42	MP0002139_abnormal_hepatobiliary_system	1.46531440
43	MP0001879_abnormal_lymphatic_vessel	1.46313530
44	MP0000767_abnormal_smooth_muscle	1.45872436
45	MP0002108_abnormal_muscle_morphology	1.43564294
46	MP0002822_catalepsy	1.42060287
47	MP0005395_other_phenotype	1.38177886
48	MP0004036_abnormal_muscle_relaxation	1.37285211
49	MP0009046_muscle_twitch	1.33263727
50	MP0006138_congestive_heart_failure	1.27533757
51	MP0001299_abnormal_eye_distance/	1.17363216
52	MP0002060_abnormal_skin_morphology	1.13224884
53	MP0001666_abnormal_nutrient_absorption	1.06756233
54	MP0004147_increased_porphyrin_level	0.98371443
55	MP0009384_cardiac_valve_regurgitation	0.97877814
56	MP0009115_abnormal_fat_cell	0.94518900
57	MP0008961_abnormal_basal_metabolism	0.94043346
58	MP0003935_abnormal_craniofacial_develop	0.93901592
59	MP0002135_abnormal_kidney_morphology	0.92933299
60	MP0010329_abnormal_lipoprotein_level	0.92790354
61	MP0000631_abnormal_neuroendocrine_gland	0.91841403
62	MP0002229_neurodegeneration	0.91316716
63	MP0003646_muscle_fatigue	0.90054869
64	MP0005388_respiratory_system_phenotype	0.89862293
65	MP0002133_abnormal_respiratory_system	0.89862293
66	MP0000534_abnormal_ureter_morphology	0.89344162
67	MP0005595_abnormal_vascular_smooth	0.89225243
68	MP0005164_abnormal_response_to	0.88954653
69	MP0000751_myopathy	0.88702227
70	MP0005646_abnormal_pituitary_gland	0.86763633
71	MP0002876_abnormal_thyroid_physiology	0.85840484
72	MP0009697_abnormal_copulation	0.83333996
73	MP0000462_abnormal_digestive_system	0.83295735
74	MP0005220_abnormal_exocrine_pancreas	0.82233482
75	MP0000427_abnormal_hair_cycle	0.82228018
76	MP0001177_atelectasis	0.81637858
77	MP0009643_abnormal_urine_homeostasis	0.80610260
78	MP0002254_reproductive_system_inflammat	0.78288404
79	MP0002277_abnormal_respiratory_mucosa	0.77534230
80	MP0001324_abnormal_eye_pigmentation	0.75548116
81	MP0001963_abnormal_hearing_physiology	0.75203936
82	MP0000639_abnormal_adrenal_gland	0.74998202
83	MP0002128_abnormal_blood_circulation	0.73348952
84	MP0005332_abnormal_amino_acid	0.72806714
85	MP0003942_abnormal_urinary_system	0.72037403
86	MP0005620_abnormal_muscle_contractility	0.70888483
87	MP0005187_abnormal_penis_morphology	0.70143431
88	MP0000465_gastrointestinal_hemorrhage	0.70129443
89	MP0001502_abnormal_circadian_rhythm	0.69027215
90	MP0005023_abnormal_wound_healing	0.64908656
91	MP0005389_reproductive_system_phenotype	0.64264342
92	MP0003656_abnormal_erythrocyte_physiolo	0.62150661
93	MP0002925_abnormal_cardiovascular_devel	0.61766196
94	MP0000627_abnormal_mammary_gland	0.61229607
95	MP0003943_abnormal_hepatobiliary_system	0.60515071
96	MP0004084_abnormal_cardiac_muscle	0.59908590
97	MP0001873_stomach_inflammation	0.59613820
98	MP0003718_maternal_effect	0.59562742
99	MP0005645_abnormal_hypothalamus_physiol	0.58701092
100	MP0004133_heterotaxia	0.57348741

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	8.76086179
2	Abnormal ciliary motility (HP:0012262)	8.56472975
3	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	8.15576980
4	Abnormal respiratory epithelium morphology (HP:0012253)	7.73098997
5	Abnormal respiratory motile cilium morphology (HP:0005938)	7.73098997
6	Abnormal respiratory motile cilium physiology (HP:0012261)	7.39878989
7	Chronic hepatic failure (HP:0100626)	6.20368686
8	Tubulointerstitial nephritis (HP:0001970)	5.94029369
9	Abnormal rod and cone electroretinograms (HP:0008323)	5.41119167
10	Rhinitis (HP:0012384)	5.34610489
11	Chronic bronchitis (HP:0004469)	5.32976246
12	Bony spicule pigmentary retinopathy (HP:0007737)	4.59937718
13	Constricted visual fields (HP:0001133)	4.43515959
14	Bronchiectasis (HP:0002110)	4.38373164
15	Aortic aneurysm (HP:0004942)	4.28561104
16	Bronchitis (HP:0012387)	4.01741060
17	Nasal polyposis (HP:0100582)	3.93615999
18	Subcapsular cataract (HP:0000523)	3.87263022
19	Cone-rod dystrophy (HP:0000548)	3.45041165
20	Hypoalphalipoproteinemia (HP:0003233)	3.36230247
21	Abnormality of the nasal mucosa (HP:0000433)	3.25717986
22	Abnormal hair whorl (HP:0010721)	3.20930494
23	Menstrual irregularities (HP:0000858)	3.13250542
24	Recurrent bronchitis (HP:0002837)	3.11516869
25	Renovascular hypertension (HP:0100817)	2.97719727
26	Recurrent sinusitis (HP:0011108)	2.86935589
27	Progressive sensorineural hearing impairment (HP:0000408)	2.85580636
28	Tubulointerstitial abnormality (HP:0001969)	2.74957435
29	Insulin-resistant diabetes mellitus (HP:0000831)	2.68412421
30	Supernumerary spleens (HP:0009799)	2.58078472
31	Recurrent otitis media (HP:0000403)	2.52464997
32	Posterior subcapsular cataract (HP:0007787)	2.39232537
33	Chronic sinusitis (HP:0011109)	2.37737702
34	Hyperactive renin-angiotensin system (HP:0000841)	2.29138344
35	Abnormality of the fingertips (HP:0001211)	2.19408577
36	Decreased circulating renin level (HP:0003351)	2.19163397
37	Premature skin wrinkling (HP:0100678)	2.16070804
38	Polar cataract (HP:0010696)	2.15752091
39	Infertility (HP:0000789)	2.11433137
40	Portal hypertension (HP:0001409)	2.06653012
41	Macroorchidism (HP:0000053)	2.04656026
42	Long nose (HP:0003189)	2.00757268
43	Absent/shortened dynein arms (HP:0200106)	12.4501292
44	Dynein arm defect of respiratory motile cilia (HP:0012255)	12.4501292
45	Nephronophthisis (HP:0000090)	1.97967705
46	Hyperuricemia (HP:0002149)	1.96140914
47	Increased purine levels (HP:0004368)	1.96140914
48	Hypolipoproteinemia (HP:0010981)	1.92532351
49	Heterotopia (HP:0002282)	1.92426761
50	Abnormality of the renal medulla (HP:0100957)	1.86067009
51	Abnormality of the hepatic vasculature (HP:0006707)	1.84024163
52	Bell-shaped thorax (HP:0001591)	1.83360646
53	Anteriorly placed anus (HP:0001545)	1.77319949
54	Partial agenesis of the corpus callosum (HP:0001338)	1.73593356
55	Scanning speech (HP:0002168)	1.73549713
56	Narrow nasal bridge (HP:0000446)	1.72801489
57	Delayed closure of the anterior fontanelle (HP:0001476)	1.72650233
58	Deep philtrum (HP:0002002)	1.71084086
59	Occipital encephalocele (HP:0002085)	1.68578581
60	Hyperkalemia (HP:0002153)	1.67946049
61	Molar tooth sign on MRI (HP:0002419)	1.67051684
62	Abnormality of midbrain morphology (HP:0002418)	1.67051684
63	Growth hormone deficiency (HP:0000824)	1.64951171
64	Medial flaring of the eyebrow (HP:0010747)	1.59415903
65	Wide anterior fontanel (HP:0000260)	1.58511822
66	Hamartoma of the eye (HP:0010568)	1.54198128
67	Congenital primary aphakia (HP:0007707)	1.53151340
68	Large for gestational age (HP:0001520)	1.52969465
69	Central scotoma (HP:0000603)	1.50369357
70	Aortic dissection (HP:0002647)	1.50130008
71	Narrow palate (HP:0000189)	1.49066888
72	Papillary thyroid carcinoma (HP:0002895)	1.48350255
73	Type II diabetes mellitus (HP:0005978)	1.46523094
74	Gait imbalance (HP:0002141)	1.46018390
75	Recurrent pneumonia (HP:0006532)	1.44473195
76	Nephritis (HP:0000123)	1.43796017
77	Truncal obesity (HP:0001956)	1.41682580
78	Goiter (HP:0000853)	1.40845030
79	Cerebellar dysplasia (HP:0007033)	1.40398929
80	Astrocytoma (HP:0009592)	1.40382892
81	Abnormality of the astrocytes (HP:0100707)	1.40382892
82	Renal salt wasting (HP:0000127)	1.39207327
83	Neoplasm of the heart (HP:0100544)	1.36286401
84	Gingivitis (HP:0000230)	1.36031351
85	Nephrogenic diabetes insipidus (HP:0009806)	1.35940739
86	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.35847924
87	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.34692052
88	Scotoma (HP:0000575)	1.34503569
89	Broad hallux (HP:0010055)	1.34444911
90	Retinitis pigmentosa (HP:0000510)	1.34297344
91	Progressive hearing impairment (HP:0001730)	1.33627677
92	Abnormality of the nasal septum (HP:0000419)	1.32874432
93	Dilatation of the ascending aorta (HP:0005111)	1.31346010
94	Tubular atrophy (HP:0000092)	1.31084087
95	Nephrocalcinosis (HP:0000121)	1.30615195
96	Abnormality of the 2nd finger (HP:0004100)	1.29843888
97	Hypokalemic alkalosis (HP:0001949)	1.29483990
98	Dental crowding (HP:0000678)	1.28407771
99	Vaginal atresia (HP:0000148)	1.27973021
100	Intrahepatic cholestasis (HP:0001406)	1.27601622

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.02512392
2	BCR	3.69365809
3	MAP4K2	3.63204851
4	MST4	3.54449974
5	MAPK15	2.91977297
6	STK16	2.87237137
7	CDK12	2.76210267
8	PIK3CA	2.70176775
9	LATS1	2.34168920
10	TYK2	2.02903270
11	IRAK1	2.01918797
12	ERBB2	1.94230059
13	CDK8	1.91069412
14	SGK2	1.85648089
15	MST1R	1.81755666
16	AKT3	1.74574483
17	MYLK	1.66984900
18	STK39	1.60199570
19	MET	1.37039799
20	GRK1	1.36036450
21	FER	1.31429138
22	DMPK	1.30987582
23	CSNK1A1L	1.28002333
24	TLK1	1.24016248
25	SGK223	1.22855604
26	SGK494	1.22855604
27	BMPR1B	1.22511364
28	MUSK	1.19156174
29	EPHA3	1.16636184
30	MAP3K7	1.15137594
31	OXSR1	1.13945468
32	EIF2AK3	1.13358293
33	NLK	1.09567013
34	TRPM7	1.07188686
35	TTN	1.06029467
36	CDC42BPA	1.05757830
37	TGFBR1	1.04718977
38	RPS6KA2	1.01493243
39	PDGFRB	0.95374293
40	NEK9	0.93720240
41	FGFR2	0.92194748
42	NUAK1	0.88072443
43	STK11	0.87347334
44	WNK1	0.86982983
45	SGK3	0.85581995
46	OBSCN	0.82378169
47	STK3	0.81468726
48	MAP3K2	0.81161735
49	ACVR1B	0.80302145
50	PAK3	0.77763345
51	PNCK	0.76060890
52	STK38L	0.75754530
53	PRKCE	0.74027795
54	PIK3CG	0.70644309
55	MKNK2	0.70561959
56	MARK2	0.69121394
57	CSNK1G1	0.68962439
58	CLK1	0.67891982
59	MELK	0.66836863
60	EIF2AK1	0.65176763
61	JAK1	0.63808294
62	GSK3A	0.63491877
63	IRAK2	0.63207125
64	CHUK	0.61020301
65	EGFR	0.60512153
66	BLK	0.60204322
67	PLK2	0.59791080
68	MAPKAPK2	0.59603512
69	PTK6	0.59593754
70	ZAK	0.58632185
71	MAP3K4	0.57897264
72	PDK2	0.57289503
73	RPS6KA6	0.55934495
74	PRKCI	0.55908990
75	CAMK1G	0.53257446
76	ADRBK1	0.52968866
77	PBK	0.52731714
78	TIE1	0.50617837
79	FGFR1	0.50225202
80	ERBB4	0.47960759
81	INSRR	0.47367771
82	PTK2B	0.45926618
83	BUB1	0.43260619
84	DAPK2	0.42802298
85	ADRBK2	0.42140327
86	BRD4	0.38305553
87	MTOR	0.37920217
88	PRKD1	0.37536308
89	AKT2	0.37475673
90	WNK3	0.36640525
91	RPS6KC1	0.36326969
92	RPS6KL1	0.36326969
93	STK4	0.35910567
94	IRAK4	0.35440581
95	ROCK1	0.35046409
96	WNK4	0.34172559
97	CAMK2A	0.33685811
98	VRK1	0.33296369
99	TRIM28	0.32482256
100	TGFBR2	0.31306885

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.11462213
2	ABC transporters_Homo sapiens_hsa02010	3.17435965
3	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.09811041
4	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.91807274
5	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.57080981
6	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.56980978
7	Retinol metabolism_Homo sapiens_hsa00830	2.37588656
8	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.36822886
9	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.06245680
10	Chemical carcinogenesis_Homo sapiens_hsa05204	2.05179614
11	Histidine metabolism_Homo sapiens_hsa00340	1.99713669
12	ECM-receptor interaction_Homo sapiens_hsa04512	1.98310435
13	Circadian rhythm_Homo sapiens_hsa04710	1.95454609
14	Adherens junction_Homo sapiens_hsa04520	1.93670131
15	Complement and coagulation cascades_Homo sapiens_hsa04610	1.93305448
16	Arginine biosynthesis_Homo sapiens_hsa00220	1.90424601
17	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.85642582
18	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.78652579
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.72663720
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.66551528
21	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.56801119
22	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.55071953
23	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.51219064
24	Sphingolipid metabolism_Homo sapiens_hsa00600	1.49952122
25	Huntingtons disease_Homo sapiens_hsa05016	1.48529512
26	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.47581367
27	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.40092284
28	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.36856802
29	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.26046791
30	Focal adhesion_Homo sapiens_hsa04510	1.20825690
31	Small cell lung cancer_Homo sapiens_hsa05222	1.16650489
32	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.11320038
33	Peroxisome_Homo sapiens_hsa04146	1.09495616
34	Lysine degradation_Homo sapiens_hsa00310	1.06962962
35	Protein digestion and absorption_Homo sapiens_hsa04974	1.06592868
36	Fatty acid degradation_Homo sapiens_hsa00071	1.05210536
37	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.02617702
38	Mineral absorption_Homo sapiens_hsa04978	1.01404557
39	beta-Alanine metabolism_Homo sapiens_hsa00410	0.98936361
40	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.98020323
41	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.97604453
42	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.97509683
43	Nitrogen metabolism_Homo sapiens_hsa00910	0.96147614
44	Taste transduction_Homo sapiens_hsa04742	0.95030960
45	Tight junction_Homo sapiens_hsa04530	0.94148233
46	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.94043332
47	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.90862645
48	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.90559468
49	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.86005560
50	Amoebiasis_Homo sapiens_hsa05146	0.85469568
51	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.84897648
52	Tyrosine metabolism_Homo sapiens_hsa00350	0.83089940
53	One carbon pool by folate_Homo sapiens_hsa00670	0.81200287
54	Propanoate metabolism_Homo sapiens_hsa00640	0.79612827
55	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.79563467
56	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.78527006
57	Phototransduction_Homo sapiens_hsa04744	0.76212727
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.70687543
59	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.69489173
60	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.67575644
61	PPAR signaling pathway_Homo sapiens_hsa03320	0.64453653
62	Nicotine addiction_Homo sapiens_hsa05033	0.63288185
63	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.61073162
64	Phenylalanine metabolism_Homo sapiens_hsa00360	0.59469578
65	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.53874573
66	Proteoglycans in cancer_Homo sapiens_hsa05205	0.52342018
67	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.51137751
68	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.49862052
69	Regulation of autophagy_Homo sapiens_hsa04140	0.49302402
70	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.48411801
71	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.47085369
72	Basal transcription factors_Homo sapiens_hsa03022	0.47003738
73	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.46779863
74	Hippo signaling pathway_Homo sapiens_hsa04390	0.43557838
75	Prostate cancer_Homo sapiens_hsa05215	0.43374580
76	Salivary secretion_Homo sapiens_hsa04970	0.42367301
77	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.42288911
78	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.42271029
79	Caffeine metabolism_Homo sapiens_hsa00232	0.42157454
80	Arginine and proline metabolism_Homo sapiens_hsa00330	0.40612772
81	Glutamatergic synapse_Homo sapiens_hsa04724	0.39132415
82	Bile secretion_Homo sapiens_hsa04976	0.37551736
83	ErbB signaling pathway_Homo sapiens_hsa04012	0.37525144
84	Prolactin signaling pathway_Homo sapiens_hsa04917	0.36653682
85	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.36490090
86	Calcium signaling pathway_Homo sapiens_hsa04020	0.34844875
87	Serotonergic synapse_Homo sapiens_hsa04726	0.34104962
88	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.31613114
89	Thyroid cancer_Homo sapiens_hsa05216	0.30149814
90	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.29694418
91	MicroRNAs in cancer_Homo sapiens_hsa05206	0.27521510
92	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.27299246
93	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.26760875
94	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.26432558
95	Basal cell carcinoma_Homo sapiens_hsa05217	0.25786134
96	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.25353939
97	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.25332282
98	Melanoma_Homo sapiens_hsa05218	0.24844449
99	GABAergic synapse_Homo sapiens_hsa04727	0.24262632
100	Pathways in cancer_Homo sapiens_hsa05200	0.23136894

PRDX3P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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