PRDX4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.13249673
2intestinal cholesterol absorption (GO:0030299)5.04245235
3serine family amino acid biosynthetic process (GO:0009070)4.65382484
4L-phenylalanine catabolic process (GO:0006559)4.54599378
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.54599378
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.51942881
7L-phenylalanine metabolic process (GO:0006558)4.51942881
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.33350809
9glycine metabolic process (GO:0006544)4.31325763
10L-serine metabolic process (GO:0006563)4.17622429
11regulation of mitochondrial translation (GO:0070129)4.16793019
12exocrine pancreas development (GO:0031017)4.15470928
13cysteine metabolic process (GO:0006534)4.12259453
14homocysteine metabolic process (GO:0050667)4.01232235
15protein retention in ER lumen (GO:0006621)3.87075447
16serine family amino acid metabolic process (GO:0009069)3.80484845
17chaperone-mediated protein transport (GO:0072321)3.78172742
18establishment of protein localization to mitochondrial membrane (GO:0090151)3.76785635
19maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.72724872
20energy coupled proton transport, down electrochemical gradient (GO:0015985)3.71535465
21ATP synthesis coupled proton transport (GO:0015986)3.71535465
22aldehyde catabolic process (GO:0046185)3.69099001
23negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.67786279
24proline biosynthetic process (GO:0006561)3.67616165
25aromatic amino acid family catabolic process (GO:0009074)3.60323615
26glyoxylate metabolic process (GO:0046487)3.58340326
27folic acid metabolic process (GO:0046655)3.51648937
28regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.50170405
29tetrahydrofolate metabolic process (GO:0046653)3.49527350
30establishment of integrated proviral latency (GO:0075713)3.45917860
31serine family amino acid catabolic process (GO:0009071)3.45117430
32positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.44787652
33ribosomal small subunit assembly (GO:0000028)3.44494967
34negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.44106117
35negative regulation of ligase activity (GO:0051352)3.44106117
36triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.40280474
37anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.39656479
38negative regulation of fibrinolysis (GO:0051918)3.38830612
39peptidyl-glutamic acid carboxylation (GO:0017187)3.33943348
40protein carboxylation (GO:0018214)3.33943348
41protein targeting to mitochondrion (GO:0006626)3.33753353
42SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.32598502
43sulfur amino acid catabolic process (GO:0000098)3.29778539
44CENP-A containing nucleosome assembly (GO:0034080)3.29497744
45chromatin remodeling at centromere (GO:0031055)3.28457385
46cullin deneddylation (GO:0010388)3.26616760
47mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.26399033
48cotranslational protein targeting to membrane (GO:0006613)3.25750556
49one-carbon metabolic process (GO:0006730)3.25488564
50protein targeting to ER (GO:0045047)3.24466479
51bile acid biosynthetic process (GO:0006699)3.21342383
52viral transcription (GO:0019083)3.18796365
53regulation of fibrinolysis (GO:0051917)3.16031517
54regulation of cellular amino acid metabolic process (GO:0006521)3.15726595
55translational termination (GO:0006415)3.15291340
56respiratory electron transport chain (GO:0022904)3.13927638
57folic acid-containing compound biosynthetic process (GO:0009396)3.11148336
58protein localization to endoplasmic reticulum (GO:0070972)3.09614981
59protein deneddylation (GO:0000338)3.06813362
60folic acid-containing compound metabolic process (GO:0006760)3.05401261
61electron transport chain (GO:0022900)3.04837472
62establishment of protein localization to endoplasmic reticulum (GO:0072599)3.04414580
63sulfur amino acid biosynthetic process (GO:0000097)3.04071389
64establishment of protein localization to mitochondrion (GO:0072655)3.03862916
65nucleobase-containing small molecule interconversion (GO:0015949)3.03744406
66formation of translation preinitiation complex (GO:0001731)3.02443202
67ribosome assembly (GO:0042255)3.00925592
68positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.99880942
69proline metabolic process (GO:0006560)2.99460018
70protein complex biogenesis (GO:0070271)2.98449225
71protein localization to mitochondrion (GO:0070585)2.97920357
72mitochondrial respiratory chain complex assembly (GO:0033108)2.97116172
73regulation of protein activation cascade (GO:2000257)2.95746248
74Golgi transport vesicle coating (GO:0048200)2.94863568
75COPI coating of Golgi vesicle (GO:0048205)2.94863568
76establishment of viral latency (GO:0019043)2.94703049
77ribonucleoprotein complex biogenesis (GO:0022613)2.93705867
78mitotic metaphase plate congression (GO:0007080)2.92150824
79oxidative phosphorylation (GO:0006119)2.91758571
80cellular modified amino acid catabolic process (GO:0042219)2.91343029
81ribosomal small subunit biogenesis (GO:0042274)2.90357975
82pteridine-containing compound biosynthetic process (GO:0042559)2.89129975
83transcription elongation from RNA polymerase III promoter (GO:0006385)2.88589001
84termination of RNA polymerase III transcription (GO:0006386)2.88589001
85high-density lipoprotein particle remodeling (GO:0034375)2.86465585
86DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.86409519
87positive regulation of ligase activity (GO:0051351)2.86260302
88tryptophan catabolic process (GO:0006569)2.85299469
89indole-containing compound catabolic process (GO:0042436)2.85299469
90indolalkylamine catabolic process (GO:0046218)2.85299469
91cholesterol catabolic process (GO:0006707)2.85204687
92sterol catabolic process (GO:0016127)2.85204687
93pteridine-containing compound metabolic process (GO:0042558)2.85136572
94intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.84147864
95signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.84147864
96tryptophan metabolic process (GO:0006568)2.84104796
97signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.83755859
98signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.83755859
99signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.83755859
100translational elongation (GO:0006414)2.82448183
101mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.81467553
102mitochondrial respiratory chain complex I assembly (GO:0032981)2.81467553
103NADH dehydrogenase complex assembly (GO:0010257)2.81467553
104* protein maturation by protein folding (GO:0022417)2.81391479
105cellular component biogenesis (GO:0044085)2.81199185
106DNA replication checkpoint (GO:0000076)2.81140813
107signal peptide processing (GO:0006465)2.80904532
108regulation of ubiquitin-protein transferase activity (GO:0051438)2.80001874
109signal transduction involved in DNA damage checkpoint (GO:0072422)2.79832373
110signal transduction involved in DNA integrity checkpoint (GO:0072401)2.79832373
111spliceosomal snRNP assembly (GO:0000387)2.79329104
112alpha-linolenic acid metabolic process (GO:0036109)2.79251457
113peptidyl-histidine modification (GO:0018202)2.77918543
114respiratory chain complex IV assembly (GO:0008535)2.77758966
115alpha-amino acid catabolic process (GO:1901606)2.77722186
116kynurenine metabolic process (GO:0070189)2.77716193
117pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.77617477
118regulation of complement activation (GO:0030449)2.77461807
119purine nucleobase biosynthetic process (GO:0009113)2.76276368
120pseudouridine synthesis (GO:0001522)2.74644954
121signal transduction involved in cell cycle checkpoint (GO:0072395)2.74383777
122alpha-amino acid biosynthetic process (GO:1901607)2.73722335
123digestion (GO:0007586)2.73547300
124cofactor catabolic process (GO:0051187)2.73086440
125rRNA modification (GO:0000154)2.72487056
126aromatic amino acid family metabolic process (GO:0009072)2.72233864
127protein neddylation (GO:0045116)2.71609551
128tRNA aminoacylation for protein translation (GO:0006418)2.69871680
129branched-chain amino acid catabolic process (GO:0009083)2.69794981
130maturation of SSU-rRNA (GO:0030490)2.69722518
131regulation of ligase activity (GO:0051340)2.69346894
132deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.69136888
133pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.68376466
134coenzyme catabolic process (GO:0009109)2.68226098
135guanosine-containing compound biosynthetic process (GO:1901070)2.66552409
136tRNA aminoacylation (GO:0043039)2.65852750
137amino acid activation (GO:0043038)2.65852750
138nucleobase biosynthetic process (GO:0046112)2.65734379
139complement activation, alternative pathway (GO:0006957)2.65462391
140DNA deamination (GO:0045006)2.62379998
141histone exchange (GO:0043486)2.62001639
142telomere maintenance via recombination (GO:0000722)2.61933539
143DNA strand elongation involved in DNA replication (GO:0006271)2.61862582
144rRNA processing (GO:0006364)2.61379704
145cellular amino acid catabolic process (GO:0009063)2.60948337
146translation (GO:0006412)2.60265369
147metaphase plate congression (GO:0051310)2.60155890
148ribosome biogenesis (GO:0042254)2.59673039
149dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.59070044
150lysine metabolic process (GO:0006553)2.58856388
151lysine catabolic process (GO:0006554)2.58856388
152DNA unwinding involved in DNA replication (GO:0006268)2.58555399
153DNA damage response, detection of DNA damage (GO:0042769)2.57975869
154bile acid metabolic process (GO:0008206)2.57764546
155ventricular cardiac muscle cell development (GO:0055015)2.56560194
156translational initiation (GO:0006413)2.56303929
157complement activation, classical pathway (GO:0006958)2.55292946
158urea metabolic process (GO:0019627)2.55053334
159urea cycle (GO:0000050)2.55053334
160intestinal absorption (GO:0050892)2.54020745
161aspartate family amino acid metabolic process (GO:0009066)2.53641141
162reverse cholesterol transport (GO:0043691)2.53609867
163telomere maintenance via semi-conservative replication (GO:0032201)2.52026685
164S-adenosylmethionine metabolic process (GO:0046500)2.51468694
165plasma lipoprotein particle clearance (GO:0034381)2.48722859
166DNA strand elongation (GO:0022616)2.47403679
167response to nitrosative stress (GO:0051409)2.46700481
168transcytosis (GO:0045056)2.46122001
169peptidyl-proline hydroxylation (GO:0019511)2.45602538
170nucleoside salvage (GO:0043174)2.45071613
171regulation of cholesterol esterification (GO:0010872)2.44794920
172glutamine family amino acid biosynthetic process (GO:0009084)2.43827387
173ribosomal large subunit biogenesis (GO:0042273)2.43423485
174regulation of plasminogen activation (GO:0010755)2.42639804
175plasma lipoprotein particle remodeling (GO:0034369)2.42343368
176protein-lipid complex remodeling (GO:0034368)2.42343368
177macromolecular complex remodeling (GO:0034367)2.42343368
178L-methionine biosynthetic process (GO:0071265)2.42308467

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.03198898
2E2F7_22180533_ChIP-Seq_HELA_Human4.97783334
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.79645099
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.41276822
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.34800045
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.22620373
7RXR_22158963_ChIP-Seq_LIVER_Mouse3.14956773
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.08318151
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.98866634
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.92799389
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.89156454
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.72639679
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.72583165
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.58072681
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.56778773
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.51698756
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.48676725
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.39427846
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.35612925
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.33619950
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.32930707
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.30610078
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.29280222
24LXR_22158963_ChIP-Seq_LIVER_Mouse2.20122968
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.09973794
26E2F4_17652178_ChIP-ChIP_JURKAT_Human2.09892889
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.07026914
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.05123217
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.01909777
30AR_21909140_ChIP-Seq_LNCAP_Human2.01303965
31DCP1A_22483619_ChIP-Seq_HELA_Human1.95109324
32XRN2_22483619_ChIP-Seq_HELA_Human1.90489410
33HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.86857418
34* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.73269659
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.70422961
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.69398986
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.66612399
38GABP_19822575_ChIP-Seq_HepG2_Human1.61551775
39VDR_23849224_ChIP-Seq_CD4+_Human1.61153209
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59274226
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.56860493
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54939195
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54260795
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.51013062
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47285804
46* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47112509
47FOXP3_21729870_ChIP-Seq_TREG_Human1.46451834
48ELK1_19687146_ChIP-ChIP_HELA_Human1.43612597
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.41899752
50TTF2_22483619_ChIP-Seq_HELA_Human1.41459318
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.40810904
52ZNF263_19887448_ChIP-Seq_K562_Human1.39019063
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38983229
54STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37748693
55TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36172924
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34562490
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32354171
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.28716112
59TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27474079
60DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27277694
61CLOCK_20551151_ChIP-Seq_293T_Human1.25131247
62DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25077467
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24058347
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20965100
65ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.20150171
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18559420
67KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.18382727
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17716993
69PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17565082
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17522618
71HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16190390
72CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15621587
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15269984
74RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15062586
75CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.14290988
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14202707
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13663475
78ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13113375
79HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13070229
80STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11876012
81HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11687642
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08911049
83ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07850859
84NANOG_16153702_ChIP-ChIP_HESCs_Human1.07716168
85* TFEB_21752829_ChIP-Seq_HELA_Human1.06129678
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04601200
87SOX17_20123909_ChIP-Seq_XEN_Mouse1.04356282
88YY1_21170310_ChIP-Seq_MESCs_Mouse1.03038278
89ELK1_22589737_ChIP-Seq_MCF10A_Human1.00916437
90SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00877103
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00576632
92CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99508697
93NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99168118
94KDM5A_27292631_Chip-Seq_BREAST_Human0.98456687
95MYC_18940864_ChIP-ChIP_HL60_Human0.97789784
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96927654
97RBPJ_22232070_ChIP-Seq_NCS_Mouse0.96531982
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96012277
99TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.95805229
100FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95752555
101NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95549845
102ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95273200
103SOX2_18692474_ChIP-Seq_MEFs_Mouse0.94868163
104POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91836496
105KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91143193
106CTCF_18555785_ChIP-Seq_MESCs_Mouse0.90807758
107SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.89784276
108CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.89390263
109IRF8_22096565_ChIP-ChIP_GC-B_Human0.89233644
110HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.88574786
111TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84004976
112E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.83975184
113EOMES_21245162_ChIP-Seq_HESCs_Human0.83001275
114SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82541149
115* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82243541
116PADI4_21655091_ChIP-ChIP_MCF-7_Human0.81908566
117TBX5_21415370_ChIP-Seq_HL-1_Mouse0.80068798
118* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.79378991
119KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.78262544

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract4.73881175
2MP0005365_abnormal_bile_salt4.58599573
3MP0002139_abnormal_hepatobiliary_system4.57395991
4MP0005085_abnormal_gallbladder_physiolo4.10962396
5MP0003806_abnormal_nucleotide_metabolis3.96218091
6MP0005360_urolithiasis3.95225677
7MP0001666_abnormal_nutrient_absorption3.59160609
8MP0008438_abnormal_cutaneous_collagen2.51706389
9MP0005220_abnormal_exocrine_pancreas2.45909035
10MP0003705_abnormal_hypodermis_morpholog2.30963591
11MP0003693_abnormal_embryo_hatching2.16387458
12MP0003941_abnormal_skin_development2.13151265
13MP0009840_abnormal_foam_cell2.12080623
14MP0008875_abnormal_xenobiotic_pharmacok2.08369523
15MP0005084_abnormal_gallbladder_morpholo2.05244538
16MP0003786_premature_aging2.04298650
17MP0005332_abnormal_amino_acid1.92333747
18MP0003252_abnormal_bile_duct1.85306275
19* MP0003186_abnormal_redox_activity1.73621226
20MP0010329_abnormal_lipoprotein_level1.72801571
21MP0004957_abnormal_blastocyst_morpholog1.71520474
22MP0006054_spinal_hemorrhage1.69766242
23MP0003195_calcinosis1.66653072
24MP0003868_abnormal_feces_composition1.64631488
25MP0009697_abnormal_copulation1.63011903
26MP0003123_paternal_imprinting1.62325475
27MP0005503_abnormal_tendon_morphology1.53713740
28MP0006035_abnormal_mitochondrial_morpho1.45909434
29MP0005257_abnormal_intraocular_pressure1.43963331
30MP0005451_abnormal_body_composition1.40310130
31MP0000358_abnormal_cell_content/1.39802386
32MP0003937_abnormal_limbs/digits/tail_de1.39559078
33MP0002163_abnormal_gland_morphology1.38744648
34MP0003011_delayed_dark_adaptation1.37572342
35MP0005408_hypopigmentation1.37333410
36MP0001764_abnormal_homeostasis1.35688040
37MP0000372_irregular_coat_pigmentation1.33874766
38MP0010030_abnormal_orbit_morphology1.29649107
39MP0009053_abnormal_anal_canal1.28919147
40MP0002282_abnormal_trachea_morphology1.28048754
41MP0009379_abnormal_foot_pigmentation1.26726716
42MP0003077_abnormal_cell_cycle1.26163019
43MP0008877_abnormal_DNA_methylation1.25997665
44MP0001293_anophthalmia1.24498143
45MP0006292_abnormal_olfactory_placode1.23523504
46MP0000537_abnormal_urethra_morphology1.22751677
47MP0005623_abnormal_meninges_morphology1.22026015
48MP0002697_abnormal_eye_size1.21214033
49MP0001661_extended_life_span1.21204631
50MP0000609_abnormal_liver_physiology1.18830712
51MP0002233_abnormal_nose_morphology1.18820465
52MP0005319_abnormal_enzyme/_coenzyme1.17267970
53* MP0002210_abnormal_sex_determination1.16318180
54MP0010368_abnormal_lymphatic_system1.16222660
55MP0002160_abnormal_reproductive_system1.15114046
56MP0009384_cardiac_valve_regurgitation1.14673980
57MP0008932_abnormal_embryonic_tissue1.13053057
58MP0000598_abnormal_liver_morphology1.13047070
59MP0002084_abnormal_developmental_patter1.12491253
60MP0010094_abnormal_chromosome_stability1.10769249
61MP0003718_maternal_effect1.09173845
62MP0004272_abnormal_basement_membrane1.07807771
63MP0005379_endocrine/exocrine_gland_phen1.07214220
64MP0002085_abnormal_embryonic_tissue1.07122566
65MP0003111_abnormal_nucleus_morphology1.05181391
66MP0002118_abnormal_lipid_homeostasis1.03481477
67MP0008789_abnormal_olfactory_epithelium1.03031155
68MP0000049_abnormal_middle_ear1.02300039
69MP0001299_abnormal_eye_distance/1.01783758
70MP0003136_yellow_coat_color1.00326172
71MP0005023_abnormal_wound_healing0.99801548
72MP0003385_abnormal_body_wall0.98405858
73MP0002090_abnormal_vision0.98107338
74* MP0001145_abnormal_male_reproductive0.95783392
75MP0004019_abnormal_vitamin_homeostasis0.94272904
76* MP0000653_abnormal_sex_gland0.92770586
77MP0002132_abnormal_respiratory_system0.89926689
78MP0003656_abnormal_erythrocyte_physiolo0.89806410
79* MP0001929_abnormal_gametogenesis0.88835255
80MP0005330_cardiomyopathy0.88020592
81MP0008007_abnormal_cellular_replicative0.87669590
82MP0002938_white_spotting0.86534715
83MP0003191_abnormal_cellular_cholesterol0.84061399
84MP0003942_abnormal_urinary_system0.83610711
85MP0001243_abnormal_dermal_layer0.82419899
86MP0009643_abnormal_urine_homeostasis0.81497835
87MP0000762_abnormal_tongue_morphology0.80703186
88MP0003567_abnormal_fetal_cardiomyocyte0.80678955
89MP0005197_abnormal_uvea_morphology0.80204298
90MP0003279_aneurysm0.78281158
91MP0006072_abnormal_retinal_apoptosis0.77633363
92MP0001529_abnormal_vocalization0.77335664
93MP0006036_abnormal_mitochondrial_physio0.77219977
94MP0002092_abnormal_eye_morphology0.77117795
95MP0000313_abnormal_cell_death0.76994889
96MP0000647_abnormal_sebaceous_gland0.76862824
97MP0009672_abnormal_birth_weight0.76735338
98MP0001542_abnormal_bone_strength0.76577014
99MP0001286_abnormal_eye_development0.75408419
100MP0003755_abnormal_palate_morphology0.75321869
101MP0000490_abnormal_crypts_of0.74508534
102MP0005275_abnormal_skin_tensile0.74468471
103MP0002837_dystrophic_cardiac_calcinosis0.74205455
104MP0003119_abnormal_digestive_system0.72831293
105MP0003890_abnormal_embryonic-extraembry0.71529349
106MP0009763_increased_sensitivity_to0.70930062
107MP0003283_abnormal_digestive_organ0.70544933
108MP0002138_abnormal_hepatobiliary_system0.70383134
109MP0001730_embryonic_growth_arrest0.70136796
110MP0005187_abnormal_penis_morphology0.69467161
111MP0001915_intracranial_hemorrhage0.69115504
112MP0002111_abnormal_tail_morphology0.68944170
113MP0008058_abnormal_DNA_repair0.68725130
114MP0002877_abnormal_melanocyte_morpholog0.68664307
115MP0000639_abnormal_adrenal_gland0.68284093
116MP0004197_abnormal_fetal_growth/weight/0.68244558
117MP0005376_homeostasis/metabolism_phenot0.67841467
118MP0005508_abnormal_skeleton_morphology0.66273170
119MP0000163_abnormal_cartilage_morphology0.65414116
120MP0008469_abnormal_protein_level0.64537286
121MP0004264_abnormal_extraembryonic_tissu0.64231586
122MP0001881_abnormal_mammary_gland0.63228126
123MP0004133_heterotaxia0.63064108
124MP0002249_abnormal_larynx_morphology0.62728123
125MP0002932_abnormal_joint_morphology0.62445640
126MP0003638_abnormal_response/metabolism_0.61118886
127MP0001697_abnormal_embryo_size0.61038104
128MP0003315_abnormal_perineum_morphology0.60818900
129MP0001672_abnormal_embryogenesis/_devel0.59657339
130MP0005380_embryogenesis_phenotype0.59657339
131MP0002295_abnormal_pulmonary_circulatio0.59442116
132MP0002088_abnormal_embryonic_growth/wei0.58644814
133MP0003984_embryonic_growth_retardation0.58148673
134MP0001879_abnormal_lymphatic_vessel0.58119387
135MP0003115_abnormal_respiratory_system0.56449879
136MP0009250_abnormal_appendicular_skeleto0.56393274
137MP0009333_abnormal_splenocyte_physiolog0.55344127
138MP0002080_prenatal_lethality0.53434662
139MP0005584_abnormal_enzyme/coenzyme_acti0.53002249
140MP0002060_abnormal_skin_morphology0.52873320
141MP0000350_abnormal_cell_proliferation0.52527931
142MP0005395_other_phenotype0.52426784
143MP0008057_abnormal_DNA_replication0.52298426
144MP0002086_abnormal_extraembryonic_tissu0.51935460
145MP0000750_abnormal_muscle_regeneration0.50777470
146MP0001119_abnormal_female_reproductive0.50607173
147MP0005058_abnormal_lysosome_morphology0.50285087
148MP0002115_abnormal_skeleton_extremities0.50139441

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.06165986
2Deep venous thrombosis (HP:0002625)4.35530581
3Hypobetalipoproteinemia (HP:0003563)4.20987574
4Intrahepatic cholestasis (HP:0001406)4.18922391
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.01195262
6Abnormal mitochondria in muscle tissue (HP:0008316)3.94769889
7Steatorrhea (HP:0002570)3.81530648
8Fat malabsorption (HP:0002630)3.79978862
9Prolonged partial thromboplastin time (HP:0003645)3.67021887
10Increased CSF lactate (HP:0002490)3.65802900
11Abnormality of the intrinsic pathway (HP:0010989)3.64981408
12Mitochondrial inheritance (HP:0001427)3.58350294
13Xanthomatosis (HP:0000991)3.36534039
14Type I transferrin isoform profile (HP:0003642)3.32337257
15Abnormality of the common coagulation pathway (HP:0010990)3.30085961
16Hyperglycinemia (HP:0002154)3.21074803
17Abnormality of sulfur amino acid metabolism (HP:0004339)3.20059481
18Progressive macrocephaly (HP:0004481)3.15102917
19Abnormality of pyrimidine metabolism (HP:0004353)3.13124858
20Hypolipoproteinemia (HP:0010981)3.09733288
21Abnormality of methionine metabolism (HP:0010901)3.05834761
22Microvesicular hepatic steatosis (HP:0001414)3.00390482
23Increased hepatocellular lipid droplets (HP:0006565)2.90963587
24Hyperammonemia (HP:0001987)2.90115147
25Increased serum lactate (HP:0002151)2.88330444
26Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.75607642
27Abnormal protein N-linked glycosylation (HP:0012347)2.75607642
28Abnormal protein glycosylation (HP:0012346)2.75607642
29Abnormal glycosylation (HP:0012345)2.75607642
30Multiple enchondromatosis (HP:0005701)2.74502377
31Biconcave vertebral bodies (HP:0004586)2.73264661
32Protrusio acetabuli (HP:0003179)2.72083902
33Lipid accumulation in hepatocytes (HP:0006561)2.71025180
34Lactic acidosis (HP:0003128)2.70920708
35Abnormality of aspartate family amino acid metabolism (HP:0010899)2.70055342
36Hyperlipoproteinemia (HP:0010980)2.66941859
37Abnormal cartilage morphology (HP:0002763)2.65941830
38Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.65110472
39Abnormality of alanine metabolism (HP:0010916)2.65110472
40Hyperalaninemia (HP:0003348)2.65110472
41Abnormality of glycine metabolism (HP:0010895)2.65086333
42Abnormality of serine family amino acid metabolism (HP:0010894)2.65086333
43Abnormality of the anterior horn cell (HP:0006802)2.62761844
44Degeneration of anterior horn cells (HP:0002398)2.62761844
45Complement deficiency (HP:0004431)2.62269809
46Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.61806580
47Renal Fanconi syndrome (HP:0001994)2.60137272
48Hyperglycinuria (HP:0003108)2.54152617
49Hypoglycemic coma (HP:0001325)2.53761793
50Joint hemorrhage (HP:0005261)2.52221511
51Hypoalphalipoproteinemia (HP:0003233)2.50937922
52Cerebral edema (HP:0002181)2.50684680
53Irregular epiphyses (HP:0010582)2.49844580
54Opisthotonus (HP:0002179)2.44856226
55Abnormal tarsal ossification (HP:0008369)2.42013741
56Respiratory failure (HP:0002878)2.41422269
57Exercise intolerance (HP:0003546)2.38878335
58Carpal bone hypoplasia (HP:0001498)2.37541498
59Nausea (HP:0002018)2.37028572
60Reticulocytopenia (HP:0001896)2.35790472
61Abnormality of the fetal cardiovascular system (HP:0010948)2.34749618
62Abnormal umbilical cord blood vessels (HP:0011403)2.34749618
63Single umbilical artery (HP:0001195)2.34749618
64Abnormality of serum amino acid levels (HP:0003112)2.33592444
65Abnormality of cells of the erythroid lineage (HP:0012130)2.32198160
66Ketosis (HP:0001946)2.31107354
67Abnormality of the umbilical cord (HP:0010881)2.23377433
68Lethargy (HP:0001254)2.23216158
69Beaking of vertebral bodies (HP:0004568)2.22697548
70Hepatocellular carcinoma (HP:0001402)2.21585193
71Increased intramyocellular lipid droplets (HP:0012240)2.18663895
72Reduced antithrombin III activity (HP:0001976)2.18249259
73Oral leukoplakia (HP:0002745)2.16439064
74Abnormality of dicarboxylic acid metabolism (HP:0010995)2.14255149
75Dicarboxylic aciduria (HP:0003215)2.14255149
76Abnormality of complement system (HP:0005339)2.13814311
77Abnormality of nucleobase metabolism (HP:0010932)2.11602126
78Abnormality of glutamine family amino acid metabolism (HP:0010902)2.11523511
79Macrocytic anemia (HP:0001972)2.10749923
80Abnormality of fatty-acid metabolism (HP:0004359)2.09189225
81Myocardial infarction (HP:0001658)2.09039365
82Acute encephalopathy (HP:0006846)2.08586746
83Secondary amenorrhea (HP:0000869)2.06734521
84Respiratory difficulties (HP:0002880)2.06399216
85CNS demyelination (HP:0007305)2.06355702
86Abnormal number of erythroid precursors (HP:0012131)2.04587987
87Epiphyseal dysplasia (HP:0002656)2.03695989
88Glossoptosis (HP:0000162)2.01761852
89Vitreoretinal degeneration (HP:0000655)2.00620549
90Nonimmune hydrops fetalis (HP:0001790)1.99430877
91Spastic diplegia (HP:0001264)1.97592847
92Abnormalities of placenta or umbilical cord (HP:0001194)1.97044314
93Hepatic necrosis (HP:0002605)1.95010897
94Testicular atrophy (HP:0000029)1.91909180
95Small epiphyses (HP:0010585)1.91455101
96X-linked dominant inheritance (HP:0001423)1.91343157
97Hypoplastic pelvis (HP:0008839)1.91054636
98Redundant skin (HP:0001582)1.90802304
99Premature rupture of membranes (HP:0001788)1.90632008
100Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.89000223
101Vascular calcification (HP:0004934)1.88753078
102Delayed CNS myelination (HP:0002188)1.88746933
103Bifid tongue (HP:0010297)1.87749575
104Epidermoid cyst (HP:0200040)1.87362329
105Aplasia/Hypoplasia of the sacrum (HP:0008517)1.86676026
106Glycosuria (HP:0003076)1.86428795
107Abnormality of urine glucose concentration (HP:0011016)1.86428795
108Hyperbilirubinemia (HP:0002904)1.86035269
109Sparse eyelashes (HP:0000653)1.85889692
110Abnormality of glycolysis (HP:0004366)1.85709159
111Increased serum pyruvate (HP:0003542)1.85709159
112Cardiovascular calcification (HP:0011915)1.85211194
113Congenital malformation of the right heart (HP:0011723)1.84522834
114Double outlet right ventricle (HP:0001719)1.84522834
115Chromsome breakage (HP:0040012)1.83186036
116Generalized aminoaciduria (HP:0002909)1.82808266
117Facial cleft (HP:0002006)1.82296521
118Cupped ribs (HP:0000887)1.82104783
119Trismus (HP:0000211)1.82077348
120Abnormal foot bone ossification (HP:0010675)1.81500562
121Megaloblastic anemia (HP:0001889)1.81255988
122Methylmalonic aciduria (HP:0012120)1.79306387
123Abnormal delivery (HP:0001787)1.78017676
124Leukodystrophy (HP:0002415)1.77848996
125Abnormality of dentin (HP:0010299)1.77556211
126Diastasis recti (HP:0001540)1.77518763
127Progressive muscle weakness (HP:0003323)1.77426177
128Blue sclerae (HP:0000592)1.77419114
129Vertebral compression fractures (HP:0002953)1.76306226
130Increased muscle lipid content (HP:0009058)1.76145615
131Chromosomal breakage induced by crosslinking agents (HP:0003221)1.75859184
132Poor head control (HP:0002421)1.75624838
133Hypercholesterolemia (HP:0003124)1.75007544
134Meckel diverticulum (HP:0002245)1.72941560
135Decreased activity of mitochondrial respiratory chain (HP:0008972)1.72547937
136Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.72547937
137Gout (HP:0001997)1.72142536
138Transposition of the great arteries (HP:0001669)1.72015091
139Abnormal connection of the cardiac segments (HP:0011545)1.72015091
140Abnormal ventriculo-arterial connection (HP:0011563)1.72015091
141Microretrognathia (HP:0000308)1.70774160
142Acute necrotizing encephalopathy (HP:0006965)1.70162877
143Hypoplasia of the capital femoral epiphysis (HP:0003090)1.69946751
144Hypoplastic left heart (HP:0004383)1.69139275
145Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.68155784
146Abnormal hemoglobin (HP:0011902)1.67854081
1473-Methylglutaconic aciduria (HP:0003535)1.67285169
148Short nail (HP:0001799)1.67189714
149Hypokinesia (HP:0002375)1.66739869
150Horseshoe kidney (HP:0000085)1.66697381
151Soft skin (HP:0000977)1.65810524
152Adrenal hypoplasia (HP:0000835)1.64156003
153Pallor (HP:0000980)1.64095682
154Pancreatitis (HP:0001733)1.61188192
155Spontaneous abortion (HP:0005268)1.61056943
156Abnormality of purine metabolism (HP:0004352)1.60840760
157Esophageal varix (HP:0002040)1.60512719
158Hyperinsulinemic hypoglycemia (HP:0000825)1.60443946
159Rough bone trabeculation (HP:0100670)1.59813020
160Vomiting (HP:0002013)1.59070061
161Abnormality of the ileum (HP:0001549)1.58546210
162Neonatal short-limb short stature (HP:0008921)1.58507954
163Abnormal lung lobation (HP:0002101)1.58021774
164Ectopia lentis (HP:0001083)1.57044292
165Hepatocellular necrosis (HP:0001404)1.55774380

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.99711086
2NME24.08759431
3VRK23.36465096
4BUB13.21949930
5ERN13.15398353
6WEE13.04669101
7EIF2AK12.51799559
8EIF2AK32.44398576
9PBK2.27922035
10BRSK22.20165981
11CDC72.13492984
12ACVR1B1.96435863
13PKN21.94740475
14STK38L1.90403671
15STK161.88202535
16KDR1.61934404
17RPS6KA41.59702394
18TRIM281.51851876
19MAP3K121.46970410
20NEK21.43442060
21MAP3K31.42999440
22ARAF1.42906382
23MST41.40922045
24NEK91.37659708
25TSSK61.36456979
26PLK11.33453612
27VRK11.31769022
28SRPK11.30577503
29AURKB1.26806083
30TRIB31.25479231
31FLT31.24168658
32PASK1.21128199
33SIK11.19760580
34MAP2K21.19447844
35PNCK1.17154926
36TAOK21.16738467
37TESK11.15997835
38PLK41.14732436
39TLK11.13763900
40TTK1.11383774
41CSNK1G31.10994969
42PIM21.07795352
43ABL21.06379117
44CSNK1G11.05430454
45MAP2K31.05112545
46DDR21.03525448
47CDK191.02754144
48TESK21.02055383
49CDK71.00581197
50MAP3K80.99582888
51BRSK10.98786797
52MKNK10.97915279
53PLK30.95899561
54CDK40.94684823
55LMTK20.94616590
56TAF10.92555036
57TGFBR10.92292054
58PAK20.92012658
59RPS6KB20.91762297
60LRRK20.88892839
61AURKA0.87395896
62NUAK10.87355018
63NEK10.84856522
64PIK3CG0.84725002
65ZAK0.84170825
66CSNK1G20.83765541
67SCYL20.82911029
68PAK40.81158450
69EPHB20.79778834
70MYLK0.79452641
71CSNK1A1L0.78739276
72BRAF0.77357086
73EIF2AK20.76710377
74STK30.72898421
75CHEK20.72610436
76CSNK2A10.69288903
77STK40.69094125
78DYRK30.68077230
79MET0.67328375
80LATS10.67006952
81MAP3K100.66165467
82MAP3K110.66145532
83ATR0.64800580
84DAPK10.62781882
85DAPK30.62006529
86PRKCI0.61448644
87LATS20.61178488
88NME10.60153939
89TYK20.59146810
90FGFR10.58730370
91ERBB40.58640971
92PTK20.58400699
93ILK0.57008617
94TBK10.55999623
95IRAK30.54373869
96AKT20.54137220
97CDK80.52845438
98CCNB10.52387059
99ATM0.52224606
100PLK20.51517665
101BCR0.51170227
102LIMK10.51090896
103PTK60.50672599
104FRK0.50652590
105PIM10.49546909
106MST1R0.49328269
107PAK10.49010710
108PDK20.47667717
109CSNK2A20.47424221
110RPS6KA50.46836327
111WNK30.46804651
112MAPK70.46470828
113PDK30.46165436
114PDK40.46165436
115DYRK20.45921521
116PINK10.45785451
117MAPK110.45688416
118ZAP700.45540400
119CDK60.45364929
120BMPR1B0.44157757
121EPHA20.44134730
122ERBB20.44016718
123RPS6KA60.42396045
124RPS6KC10.41499838
125RPS6KL10.41499838
126CHEK10.40630622
127MAPKAPK50.39953591
128MAP4K20.38938864
129MKNK20.38920033
130SMG10.38410925
131CSNK1E0.35989953
132STK390.33891884
133CDK11A0.31874580
134CDK180.30736997
135GRK10.30729392
136CDK10.30681468
137CDK140.30146530

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001202.80522815
2Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.67103657
3Folate biosynthesis_Homo sapiens_hsa007902.53567247
4Ribosome_Homo sapiens_hsa030102.46114281
5One carbon pool by folate_Homo sapiens_hsa006702.42453119
6Protein export_Homo sapiens_hsa030602.20419742
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.16405744
8DNA replication_Homo sapiens_hsa030302.15012930
9Proteasome_Homo sapiens_hsa030502.12099466
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.02101900
11Fat digestion and absorption_Homo sapiens_hsa049751.96425277
12Complement and coagulation cascades_Homo sapiens_hsa046101.85735258
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.78295363
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75176646
15Steroid biosynthesis_Homo sapiens_hsa001001.73998133
16Mismatch repair_Homo sapiens_hsa034301.66384760
17Drug metabolism - other enzymes_Homo sapiens_hsa009831.64604914
18Selenocompound metabolism_Homo sapiens_hsa004501.64589374
19Propanoate metabolism_Homo sapiens_hsa006401.58092673
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.52677306
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.52622007
22Arginine biosynthesis_Homo sapiens_hsa002201.51781830
23Biosynthesis of amino acids_Homo sapiens_hsa012301.49308863
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.48268668
25Fatty acid degradation_Homo sapiens_hsa000711.47652026
26Pyrimidine metabolism_Homo sapiens_hsa002401.47026010
27Sulfur relay system_Homo sapiens_hsa041221.46957131
28Tryptophan metabolism_Homo sapiens_hsa003801.46624496
29Chemical carcinogenesis_Homo sapiens_hsa052041.46615926
30Alzheimers disease_Homo sapiens_hsa050101.46588553
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.44076167
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.41662056
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.40737754
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.39937443
35RNA polymerase_Homo sapiens_hsa030201.36358479
36Protein digestion and absorption_Homo sapiens_hsa049741.32460087
37Peroxisome_Homo sapiens_hsa041461.31773015
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.28309920
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.25727692
40Arginine and proline metabolism_Homo sapiens_hsa003301.25579785
41Glutathione metabolism_Homo sapiens_hsa004801.25547790
42Caffeine metabolism_Homo sapiens_hsa002321.24255135
43Pyruvate metabolism_Homo sapiens_hsa006201.22217949
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.21135113
45Carbon metabolism_Homo sapiens_hsa012001.19351876
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18280184
47Nitrogen metabolism_Homo sapiens_hsa009101.17607166
48Homologous recombination_Homo sapiens_hsa034401.15986720
49Nucleotide excision repair_Homo sapiens_hsa034201.11396469
50Base excision repair_Homo sapiens_hsa034101.10080112
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08870057
52Steroid hormone biosynthesis_Homo sapiens_hsa001401.08019972
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.07986430
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06771118
55Vitamin digestion and absorption_Homo sapiens_hsa049771.05142645
56Staphylococcus aureus infection_Homo sapiens_hsa051501.04848895
57Histidine metabolism_Homo sapiens_hsa003401.04512149
58Retinol metabolism_Homo sapiens_hsa008301.04283436
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.97713057
60RNA transport_Homo sapiens_hsa030130.97707470
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.96771010
62Spliceosome_Homo sapiens_hsa030400.96506052
63Basal transcription factors_Homo sapiens_hsa030220.96402631
64Fatty acid metabolism_Homo sapiens_hsa012120.95928402
65beta-Alanine metabolism_Homo sapiens_hsa004100.95647390
66Phenylalanine metabolism_Homo sapiens_hsa003600.93841019
67PPAR signaling pathway_Homo sapiens_hsa033200.90722281
68Tyrosine metabolism_Homo sapiens_hsa003500.89618121
69Pancreatic secretion_Homo sapiens_hsa049720.85998769
70Fatty acid elongation_Homo sapiens_hsa000620.84715777
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83761077
72Starch and sucrose metabolism_Homo sapiens_hsa005000.82934407
73Sulfur metabolism_Homo sapiens_hsa009200.82761721
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81073291
75Pentose phosphate pathway_Homo sapiens_hsa000300.80408954
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79963133
77Cell cycle_Homo sapiens_hsa041100.76127916
78Butanoate metabolism_Homo sapiens_hsa006500.75925265
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75801283
80Parkinsons disease_Homo sapiens_hsa050120.73119538
81Vitamin B6 metabolism_Homo sapiens_hsa007500.71197150
82Metabolic pathways_Homo sapiens_hsa011000.71030337
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65737012
84Vibrio cholerae infection_Homo sapiens_hsa051100.65338239
85Oxidative phosphorylation_Homo sapiens_hsa001900.65060042
86Glycerolipid metabolism_Homo sapiens_hsa005610.63171103
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62100779
88Systemic lupus erythematosus_Homo sapiens_hsa053220.62074757
89Galactose metabolism_Homo sapiens_hsa000520.61806048
90N-Glycan biosynthesis_Homo sapiens_hsa005100.61088921
91Cardiac muscle contraction_Homo sapiens_hsa042600.60054979
92Purine metabolism_Homo sapiens_hsa002300.55288679
93Huntingtons disease_Homo sapiens_hsa050160.51134439
94Legionellosis_Homo sapiens_hsa051340.50947463
95Linoleic acid metabolism_Homo sapiens_hsa005910.50655708
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47840806
97p53 signaling pathway_Homo sapiens_hsa041150.45504222
98Fanconi anemia pathway_Homo sapiens_hsa034600.44287379
99Fructose and mannose metabolism_Homo sapiens_hsa000510.43871574
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43220417
101mRNA surveillance pathway_Homo sapiens_hsa030150.43132733
102Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43042398
103Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42998638
104Non-homologous end-joining_Homo sapiens_hsa034500.42688805
105Arachidonic acid metabolism_Homo sapiens_hsa005900.41327992
106Oocyte meiosis_Homo sapiens_hsa041140.41172645
107RNA degradation_Homo sapiens_hsa030180.39727751
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38487327
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37961502
110TGF-beta signaling pathway_Homo sapiens_hsa043500.37568543
111Basal cell carcinoma_Homo sapiens_hsa052170.33052067
112Sphingolipid metabolism_Homo sapiens_hsa006000.28002584
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.25406924
114Other glycan degradation_Homo sapiens_hsa005110.20319082
115Hedgehog signaling pathway_Homo sapiens_hsa043400.20077444

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