PRDX5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. This protein interacts with peroxisome receptor 1. The crystal structure of this protein in its reduced form has been resolved to 1.5 angstrom resolution. This gene uses alternate in-frame translation initiation sites to generate mitochondrial or peroxisomal/cytoplasmic forms. Three transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.21905608
2cilium movement (GO:0003341)8.78633283
3motile cilium assembly (GO:0044458)8.49261275
4epithelial cilium movement (GO:0003351)7.66594727
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.35534773
6axoneme assembly (GO:0035082)5.87825092
7left/right pattern formation (GO:0060972)5.82905257
8primary alcohol catabolic process (GO:0034310)5.54978881
9regulation of cilium movement (GO:0003352)5.20455262
10hydrogen peroxide biosynthetic process (GO:0050665)4.74631624
11ethanol metabolic process (GO:0006067)4.47927731
12reactive oxygen species biosynthetic process (GO:1903409)4.27286198
13protein maturation by protein folding (GO:0022417)4.19662400
14diterpenoid biosynthetic process (GO:0016102)4.16816373
15vitamin transmembrane transport (GO:0035461)4.14736709
16neutrophil activation involved in immune response (GO:0002283)4.09703626
17respiratory burst (GO:0045730)4.09344932
18COPI coating of Golgi vesicle (GO:0048205)3.99399235
19Golgi transport vesicle coating (GO:0048200)3.99399235
20response to peptidoglycan (GO:0032494)3.98690705
21superoxide anion generation (GO:0042554)3.95973612
22urate metabolic process (GO:0046415)3.78850403
23microtubule bundle formation (GO:0001578)3.69286861
24nucleoside diphosphate phosphorylation (GO:0006165)3.66934244
25intraciliary transport (GO:0042073)3.66800972
26aldehyde catabolic process (GO:0046185)3.65922309
27terpenoid biosynthetic process (GO:0016114)3.65279577
28lysine metabolic process (GO:0006553)3.61247515
29lysine catabolic process (GO:0006554)3.61247515
30negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.59769856
31phagosome maturation (GO:0090382)3.58675543
32GDP-mannose metabolic process (GO:0019673)3.58586930
33modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.56666398
34positive regulation by organism of defense response of other organism involved in symbiotic interact3.56666398
35modulation by symbiont of host immune response (GO:0052553)3.56666398
36positive regulation by symbiont of host defense response (GO:0052509)3.56666398
37modulation by symbiont of host defense response (GO:0052031)3.56666398
38modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.56666398
39glutathione derivative biosynthetic process (GO:1901687)3.53112311
40glutathione derivative metabolic process (GO:1901685)3.53112311
41left/right axis specification (GO:0070986)3.49571184
42lung epithelium development (GO:0060428)3.49380364
43mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.48260092
44ethanol oxidation (GO:0006069)3.47041069
45electron transport chain (GO:0022900)3.45353858
46regulation of autophagic vacuole assembly (GO:2000785)3.44784984
47respiratory electron transport chain (GO:0022904)3.40925922
48regulation of microtubule-based movement (GO:0060632)3.40829664
49mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.40084515
50response to xenobiotic stimulus (GO:0009410)3.34907877
51sperm capacitation (GO:0048240)3.30519875
52ventricular system development (GO:0021591)3.30027265
53drug transmembrane transport (GO:0006855)3.28870625
54one-carbon compound transport (GO:0019755)3.26762936
55pyrimidine-containing compound transmembrane transport (GO:0072531)3.25417583
56positive regulation of chemokine biosynthetic process (GO:0045080)3.20686571
57establishment of apical/basal cell polarity (GO:0035089)3.18026603
58lipopolysaccharide-mediated signaling pathway (GO:0031663)3.10733564
59positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.08847214
60antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.08175098
61negative regulation of T cell differentiation in thymus (GO:0033085)3.04338404
62cilium organization (GO:0044782)3.03847833
63GTP biosynthetic process (GO:0006183)3.03544550
64glyoxylate metabolic process (GO:0046487)3.01303382
65macrophage activation involved in immune response (GO:0002281)3.00304499
66drug transport (GO:0015893)2.99722647
67glutathione metabolic process (GO:0006749)2.99271864
68cilium assembly (GO:0042384)2.98568902
69fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.97570463
70protein localization to cilium (GO:0061512)2.95791675
71energy coupled proton transport, down electrochemical gradient (GO:0015985)2.94520864
72ATP synthesis coupled proton transport (GO:0015986)2.94520864
73regulation of vacuole organization (GO:0044088)2.94260014
74* hydrogen peroxide catabolic process (GO:0042744)2.89983590
75primary alcohol metabolic process (GO:0034308)2.86089120
76organic cation transport (GO:0015695)2.84837345
77protein retention in ER lumen (GO:0006621)2.83964173
78indole-containing compound catabolic process (GO:0042436)2.83232980
79indolalkylamine catabolic process (GO:0046218)2.83232980
80tryptophan catabolic process (GO:0006569)2.83232980
81retinoic acid metabolic process (GO:0042573)2.82325998
82protein insertion into membrane (GO:0051205)2.81642349
83granulocyte activation (GO:0036230)2.81261560
84production of molecular mediator involved in inflammatory response (GO:0002532)2.79419593
85retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.78856955
86nucleoside diphosphate metabolic process (GO:0009132)2.78556374
87positive regulation of cellular amide metabolic process (GO:0034250)2.78313838
88disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.77672003
89killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.77672003
90positive regulation of heat generation (GO:0031652)2.77377845
91cysteine metabolic process (GO:0006534)2.77058232
92regulation of chemokine biosynthetic process (GO:0045073)2.75724994
93aminoglycoside antibiotic metabolic process (GO:0030647)2.74178605
94low-density lipoprotein particle clearance (GO:0034383)2.73370391
95positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.73340555
96response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.72397240
97response to host immune response (GO:0052572)2.72397240
982-oxoglutarate metabolic process (GO:0006103)2.70903789
99aromatic amino acid family catabolic process (GO:0009074)2.70442456
100positive regulation of mast cell degranulation (GO:0043306)2.70422575
101positive regulation of mast cell activation involved in immune response (GO:0033008)2.70422575
102maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.70110391
103leukocyte aggregation (GO:0070486)2.70025711
104establishment of monopolar cell polarity (GO:0061162)2.69512490
105establishment or maintenance of monopolar cell polarity (GO:0061339)2.69512490
106desmosome organization (GO:0002934)2.67716111
107calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.67688336
108glomerular epithelial cell development (GO:0072310)2.66637129
109tryptophan metabolic process (GO:0006568)2.66310669
110microtubule-based movement (GO:0007018)2.66012390
111kynurenine metabolic process (GO:0070189)2.65131846
112endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.64899778
113oligosaccharide biosynthetic process (GO:0009312)2.64723229
114positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.63996822
115UTP biosynthetic process (GO:0006228)2.63370816
116retinol metabolic process (GO:0042572)2.62943624
117multicellular organismal water homeostasis (GO:0050891)2.62398628
118positive regulation of interferon-alpha production (GO:0032727)2.62149836
119regulation of fever generation (GO:0031620)2.59457670
120lipoxygenase pathway (GO:0019372)2.56962578
121erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.56551643
122L-phenylalanine metabolic process (GO:0006558)2.56551643
123regulation of metalloenzyme activity (GO:0048552)2.56461210
124positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.56255062
125nonribosomal peptide biosynthetic process (GO:0019184)2.55959112
126negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.55893476
127erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.54457841
128L-phenylalanine catabolic process (GO:0006559)2.54457841
129tricarboxylic acid metabolic process (GO:0072350)2.54412891
130response to manganese ion (GO:0010042)2.54176269
131neutrophil activation (GO:0042119)2.52732808
132L-ascorbic acid metabolic process (GO:0019852)2.51861874
133response to mercury ion (GO:0046689)2.51461036
134immunoglobulin mediated immune response (GO:0016064)2.51195733
135proline biosynthetic process (GO:0006561)2.50881873
136regulation of interleukin-5 production (GO:0032674)2.49893124
137NADH metabolic process (GO:0006734)2.49872623
138regulation of cellular amino acid metabolic process (GO:0006521)2.49300687
139calcium-mediated signaling using intracellular calcium source (GO:0035584)2.49202695
140regulation of interleukin-13 production (GO:0032656)2.48883870
141positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.48493409
142nucleotide phosphorylation (GO:0046939)2.48402499
143glutathione biosynthetic process (GO:0006750)2.48371276
144fatty acid beta-oxidation (GO:0006635)2.48312286
145amino-acid betaine metabolic process (GO:0006577)2.48254068
146extracellular fibril organization (GO:0043206)2.47922511
147leukotriene metabolic process (GO:0006691)2.47292769
148purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.46710698
149UTP metabolic process (GO:0046051)2.46197288
150nucleoside diphosphate biosynthetic process (GO:0009133)2.45432792
151drug catabolic process (GO:0042737)2.45018802
152aspartate family amino acid catabolic process (GO:0009068)2.44776941
153regulation of interferon-alpha production (GO:0032647)2.44704906
154detection of molecule of bacterial origin (GO:0032490)2.43400904
155positive regulation of mast cell activation (GO:0033005)2.43130676
156purine nucleoside triphosphate biosynthetic process (GO:0009145)2.42995934
157negative regulation of myeloid cell apoptotic process (GO:0033033)2.42899821
158guanosine-containing compound biosynthetic process (GO:1901070)2.42741250
159hydrogen ion transmembrane transport (GO:1902600)2.41996549
160regulation of cholesterol storage (GO:0010885)2.41573410
161regulation of heterotypic cell-cell adhesion (GO:0034114)2.41564861
162valine metabolic process (GO:0006573)2.39420177
163deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.39166702
164cellular aldehyde metabolic process (GO:0006081)2.39087087
165positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.38274279
166short-chain fatty acid metabolic process (GO:0046459)2.37733115
167oxidative phosphorylation (GO:0006119)2.37691325
168positive regulation of monocyte chemotaxis (GO:0090026)2.37502016
169detection of other organism (GO:0098543)2.37208775
170carnitine metabolic process (GO:0009437)2.37115338
171exogenous drug catabolic process (GO:0042738)2.36954926
172lipid oxidation (GO:0034440)2.36420120
173polyketide metabolic process (GO:0030638)2.35383830
174doxorubicin metabolic process (GO:0044598)2.35383830
175daunorubicin metabolic process (GO:0044597)2.35383830
176nucleoside triphosphate biosynthetic process (GO:0009142)2.35182530
177plasma lipoprotein particle clearance (GO:0034381)2.34843872
178response to host (GO:0075136)2.34662866
179response to host defenses (GO:0052200)2.34662866
180response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.34662866
181amyloid precursor protein catabolic process (GO:0042987)2.34643693
182cytoplasmic microtubule organization (GO:0031122)2.34406743
183cellular response to zinc ion (GO:0071294)2.33619972
184fatty acid oxidation (GO:0019395)2.33361535
185positive regulation of leukocyte degranulation (GO:0043302)2.33322742
186oxaloacetate metabolic process (GO:0006107)2.32812486
187energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.32081541
188ATP hydrolysis coupled proton transport (GO:0015991)2.32081541
189homocysteine metabolic process (GO:0050667)2.32069407
190quaternary ammonium group transport (GO:0015697)2.32068559
191* hydrogen peroxide metabolic process (GO:0042743)2.31420028
192tricarboxylic acid cycle (GO:0006099)2.28961455
193axonemal dynein complex assembly (GO:0070286)12.9528935

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.44231705
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.68456221
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.47272776
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.44772325
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.19014617
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.12136528
7RXR_22158963_ChIP-Seq_LIVER_Mouse3.33484195
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.07846585
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.95709066
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.92962137
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.79264883
12ZNF263_19887448_ChIP-Seq_K562_Human2.69783198
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.67185068
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.61726939
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.52160082
16* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.42648879
17FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.38666765
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.37564528
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.29570178
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.28577999
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.22341975
22CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.22077480
23EGR1_23403033_ChIP-Seq_LIVER_Mouse2.13956499
24SRY_22984422_ChIP-ChIP_TESTIS_Rat2.11546875
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.10818738
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.10495295
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.09569026
28MYB_21317192_ChIP-Seq_ERMYB_Mouse2.05635411
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02770136
30STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.00299013
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.94800270
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.85999594
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.83869055
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.76493146
35MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.75100134
36P68_20966046_ChIP-Seq_HELA_Human1.74543131
37ELF1_20517297_ChIP-Seq_JURKAT_Human1.72240916
38SMC4_20622854_ChIP-Seq_HELA_Human1.71295250
39SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.71016684
40CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.70226280
41TET1_21451524_ChIP-Seq_MESCs_Mouse1.63488981
42CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.56861263
43CTCF_27219007_Chip-Seq_Bcells_Human1.56587484
44ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.55180319
45NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.54321303
46ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.52667460
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42452852
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42115718
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41410327
50SA1_27219007_Chip-Seq_ERYTHROID_Human1.41390885
51CTCF_20526341_ChIP-Seq_ESCs_Human1.39127989
52PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38938165
53NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.38618850
54* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.38528110
55HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.37669475
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.37485696
57YY1_22570637_ChIP-Seq_MALME-3M_Human1.36403472
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36297963
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.34102140
60BRD4_27068464_Chip-Seq_AML-cells_Mouse1.33064780
61DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.32569814
62EGR1_19032775_ChIP-ChIP_M12_Human1.31957277
63CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.30902532
64NRF2_20460467_ChIP-Seq_MEFs_Mouse1.30280277
65NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.30280277
66MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30213386
67CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29646087
68PHF8_20622854_ChIP-Seq_HELA_Human1.29303074
69CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29265563
70STAT4_19710469_ChIP-ChIP_TH1__Mouse1.28941987
71* TP63_22573176_ChIP-Seq_HFKS_Human1.28804598
72PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.27837855
73SA1_27219007_Chip-Seq_Bcells_Human1.26784644
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25479989
75TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.24489714
76RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23026259
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22199944
78VDR_24787735_ChIP-Seq_THP-1_Human1.22037394
79SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21510061
80HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21126168
81* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20786010
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20741676
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20524621
84HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20449597
85YY1_21170310_ChIP-Seq_MESCs_Mouse1.19643318
86SOX2_20726797_ChIP-Seq_SW620_Human1.19601455
87CREB1_26743006_Chip-Seq_LNCaP_Human1.18928211
88STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.17748606
89UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17742485
90E2F1_20622854_ChIP-Seq_HELA_Human1.16920687
91ESR2_21235772_ChIP-Seq_MCF-7_Human1.16469228
92CTCF_18555785_ChIP-Seq_MESCs_Mouse1.16041673
93P63_26484246_Chip-Seq_KERATINOCYTES_Human1.15930317
94STAT1_20625510_ChIP-Seq_HELA_Human1.15879199
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15696513
96* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.14971433
97LXR_22292898_ChIP-Seq_THP-1_Human1.14531397
98STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14411402
99FOXP1_21924763_ChIP-Seq_HESCs_Human1.14218497
100* ELK3_25401928_ChIP-Seq_HUVEC_Human1.12354500
101CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11505348
102SRF_21415370_ChIP-Seq_HL-1_Mouse1.11065566
103CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11015944
104CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10875051
105SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.10252481
106CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09964017
107* RARB_24833708_ChIP-Seq_LIVER_Mouse1.09510519
108* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.08239935
109DROSHA_22980978_ChIP-Seq_HELA_Human1.07445415
110POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06848553
111PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06182006
112ATF3_27146783_Chip-Seq_COLON_Human1.05153783
113KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04976807
114PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04119886
115ESR1_21235772_ChIP-Seq_MCF-7_Human1.03397972
116PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02291003
117* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01779359
118CTCF_26484167_Chip-Seq_Bcells_Mouse1.01707112
119DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01561412
120TET1_21490601_ChIP-Seq_MESCs_Mouse1.01482090
121BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01428737
122GATA2_21666600_ChIP-Seq_HMVEC_Human1.00760619
123STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99702217
124ETS1_20019798_ChIP-Seq_JURKAT_Human0.98412753
125E2F1_18555785_ChIP-Seq_MESCs_Mouse0.97789281
126OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97772718
127SOX2_21211035_ChIP-Seq_LN229_Human0.97525319
128GABP_19822575_ChIP-Seq_HepG2_Human0.97330986
129P300_27268052_Chip-Seq_Bcells_Human0.96956347
130LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96454097
131SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96178932
132PU_27001747_Chip-Seq_BMDM_Mouse0.95449376
133CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95378150
134SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95339127
135GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93535744
136TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93499168
137GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92901266
138CLOCK_20551151_ChIP-Seq_293T_Human0.92861772
139SPI1_23547873_ChIP-Seq_NB4_Human0.91449380
140IKZF1_21737484_ChIP-ChIP_HCT116_Human0.91431156
141LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90345156
142TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.88388173
143CDX2_20551321_ChIP-Seq_CACO-2_Human0.87591031
144BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.86671524
145PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.84940618
146GATA3_26560356_Chip-Seq_TH2_Human0.83038343
147VDR_24763502_ChIP-Seq_THP-1_Human0.79803374
148SPI1_23127762_ChIP-Seq_K562_Human0.79338081
149BCL6_27268052_Chip-Seq_Bcells_Human0.78554915
150CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.78469814
151BCOR_27268052_Chip-Seq_Bcells_Human0.78210271
152JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77843913
153TAF2_19829295_ChIP-Seq_ESCs_Human0.76437845
154CJUN_26792858_Chip-Seq_BT549_Human0.75892119
155JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73266845
156SPI1_20517297_ChIP-Seq_HL60_Human0.71942208
157GATA2_19941826_ChIP-Seq_K562_Human0.71620101
158* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.71511423
159CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70509782
160RACK7_27058665_Chip-Seq_MCF-7_Human0.70251223
161MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.69392193
162GATA4_25053715_ChIP-Seq_YYC3_Human0.68392948
163SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.66922764
164RAD21_21589869_ChIP-Seq_MESCs_Mouse0.66675083
165SOX2_27498859_Chip-Seq_STOMACH_Mouse0.65926908
166NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.65248245
167GATA1_19941827_ChIP-Seq_MEL_Mouse0.64581210
168RUNX1_22412390_ChIP-Seq_EML_Mouse0.64463072
169TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.63492913

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology4.57979948
2MP0005360_urolithiasis4.13768943
3MP0003195_calcinosis3.43013781
4MP0009780_abnormal_chondrocyte_physiolo3.37105419
5MP0002132_abnormal_respiratory_system3.35155798
6MP0010234_abnormal_vibrissa_follicle3.28039609
7MP0002139_abnormal_hepatobiliary_system3.28037422
8MP0001984_abnormal_olfaction3.09573630
9MP0003436_decreased_susceptibility_to3.08403362
10MP0009785_altered_susceptibility_to2.86194912
11MP0003724_increased_susceptibility_to2.65199588
12MP0005058_abnormal_lysosome_morphology2.64710056
13MP0008789_abnormal_olfactory_epithelium2.55864866
14MP0002909_abnormal_adrenal_gland2.47872735
15MP0003191_abnormal_cellular_cholesterol2.41565986
16MP0003646_muscle_fatigue2.39899235
17MP0001835_abnormal_antigen_presentation2.39315974
18MP0005332_abnormal_amino_acid2.39250398
19MP0002148_abnormal_hypersensitivity_rea2.36879499
20MP0004043_abnormal_pH_regulation2.31441742
21MP0000566_synostosis2.25574864
22MP0004133_heterotaxia2.24116006
23MP0002419_abnormal_innate_immunity2.23514578
24MP0005623_abnormal_meninges_morphology2.23098645
25MP0006082_CNS_inflammation2.16212990
26MP0009764_decreased_sensitivity_to2.14721542
27MP0004019_abnormal_vitamin_homeostasis2.13112502
28MP0003186_abnormal_redox_activity2.08662099
29MP0003303_peritoneal_inflammation2.08361724
30MP0010030_abnormal_orbit_morphology2.03288127
31MP0005025_abnormal_response_to2.01814588
32MP0005499_abnormal_olfactory_system1.95762513
33MP0005394_taste/olfaction_phenotype1.95762513
34MP0003878_abnormal_ear_physiology1.93014553
35MP0005377_hearing/vestibular/ear_phenot1.93014553
36MP0008875_abnormal_xenobiotic_pharmacok1.92596286
37MP0005085_abnormal_gallbladder_physiolo1.91137669
38MP0003075_altered_response_to1.90172964
39MP0005451_abnormal_body_composition1.87598840
40MP0005000_abnormal_immune_tolerance1.86942307
41MP0009643_abnormal_urine_homeostasis1.86244762
42MP0002138_abnormal_hepatobiliary_system1.84634714
43MP0004510_myositis1.75744754
44MP0000343_altered_response_to1.74698952
45MP0002277_abnormal_respiratory_mucosa1.71732272
46MP0001533_abnormal_skeleton_physiology1.70146608
47MP0009840_abnormal_foam_cell1.69789322
48MP0004270_analgesia1.68585815
49MP0009379_abnormal_foot_pigmentation1.65281877
50MP0004859_abnormal_synaptic_plasticity1.64943274
51MP0005365_abnormal_bile_salt1.63912689
52MP0002837_dystrophic_cardiac_calcinosis1.63224307
53MP0008469_abnormal_protein_level1.63214628
54MP0005167_abnormal_blood-brain_barrier1.60372576
55MP0001905_abnormal_dopamine_level1.59674621
56MP0000678_abnormal_parathyroid_gland1.58698680
57MP0005584_abnormal_enzyme/coenzyme_acti1.53449357
58MP0002734_abnormal_mechanical_nocicepti1.52225523
59MP0001756_abnormal_urination1.49472804
60MP0001845_abnormal_inflammatory_respons1.48022876
61MP0002822_catalepsy1.46343914
62MP0005319_abnormal_enzyme/_coenzyme1.45929123
63MP0005166_decreased_susceptibility_to1.45806105
64MP0000604_amyloidosis1.45615868
65MP0002136_abnormal_kidney_physiology1.45263634
66MP0005636_abnormal_mineral_homeostasis1.44291134
67MP0004947_skin_inflammation1.43007388
68MP0000751_myopathy1.41643778
69MP0001790_abnormal_immune_system1.41588845
70MP0005387_immune_system_phenotype1.41588845
71MP0005535_abnormal_body_temperature1.39100266
72MP0005464_abnormal_platelet_physiology1.38568235
73MP0001765_abnormal_ion_homeostasis1.37300869
74MP0001853_heart_inflammation1.35606982
75MP0003123_paternal_imprinting1.33786241
76MP0003252_abnormal_bile_duct1.31510284
77MP0002452_abnormal_antigen_presenting1.29267711
78MP0005083_abnormal_biliary_tract1.25739528
79MP0003806_abnormal_nucleotide_metabolis1.25635738
80MP0010329_abnormal_lipoprotein_level1.24646556
81MP0002723_abnormal_immune_serum1.23699966
82MP0002998_abnormal_bone_remodeling1.22263066
83MP0004858_abnormal_nervous_system1.19535377
84MP0001958_emphysema1.17348031
85MP0004130_abnormal_muscle_cell1.15797359
86MP0003172_abnormal_lysosome_physiology1.15238678
87MP0003879_abnormal_hair_cell1.14552353
88MP0004147_increased_porphyrin_level1.14397282
89MP0000685_abnormal_immune_system1.12713340
90MP0006036_abnormal_mitochondrial_physio1.10159106
91MP0005330_cardiomyopathy1.09245660
92MP0000681_abnormal_thyroid_gland1.08184111
93MP0004782_abnormal_surfactant_physiolog1.05973144
94MP0001529_abnormal_vocalization1.05929781
95MP0005501_abnormal_skin_physiology1.05468313
96MP0002118_abnormal_lipid_homeostasis1.05147661
97MP0001849_ear_inflammation1.04525091
98MP0001819_abnormal_immune_cell1.02786281
99MP0005164_abnormal_response_to1.01799164
100MP0000579_abnormal_nail_morphology1.01671240
101MP0001800_abnormal_humoral_immune1.01346466
102MP0002876_abnormal_thyroid_physiology1.01083351
103MP0000467_abnormal_esophagus_morphology1.00218782
104MP0002796_impaired_skin_barrier1.00065985
105MP0002420_abnormal_adaptive_immunity0.99370497
106MP0000609_abnormal_liver_physiology0.98288371
107MP0002282_abnormal_trachea_morphology0.97911940
108MP0000013_abnormal_adipose_tissue0.96324169
109MP0002332_abnormal_exercise_endurance0.95927508
110MP0010678_abnormal_skin_adnexa0.94947206
111MP0003329_amyloid_beta_deposits0.94332154
112MP0000358_abnormal_cell_content/0.94108887
113MP0000858_altered_metastatic_potential0.93788449
114MP0001346_abnormal_lacrimal_gland0.90988365
115MP0005671_abnormal_response_to0.90734320
116MP0002006_tumorigenesis0.90044479
117MP0001970_abnormal_pain_threshold0.89529228
118MP0009763_increased_sensitivity_to0.88039270
119MP0005165_increased_susceptibility_to0.87680868
120MP0001727_abnormal_embryo_implantation0.87635987
121MP0004264_abnormal_extraembryonic_tissu0.87483500
122MP0000538_abnormal_urinary_bladder0.87228123
123MP0002735_abnormal_chemical_nociception0.86684211
124MP0002405_respiratory_system_inflammati0.86459549
125MP0005670_abnormal_white_adipose0.86326208
126MP0001764_abnormal_homeostasis0.84543126
127MP0003448_altered_tumor_morphology0.84382688
128MP0010155_abnormal_intestine_physiology0.84037173
129MP0003183_abnormal_peptide_metabolism0.82943911
130MP0010771_integument_phenotype0.82672963
131MP0003122_maternal_imprinting0.82236314
132MP0003011_delayed_dark_adaptation0.81540738
133MP0001666_abnormal_nutrient_absorption0.81223993
134MP0010386_abnormal_urinary_bladder0.80948695
135MP0004272_abnormal_basement_membrane0.80520242
136MP0008260_abnormal_autophagy0.78057866
137MP0003690_abnormal_glial_cell0.77920151
138MP0003283_abnormal_digestive_organ0.77207324
139MP0000762_abnormal_tongue_morphology0.77100927
140MP0009642_abnormal_blood_homeostasis0.76471242
141MP0003828_pulmonary_edema0.75321198
142MP0003137_abnormal_impulse_conducting0.74253521
143MP0006035_abnormal_mitochondrial_morpho0.73699040
144MP0002098_abnormal_vibrissa_morphology0.72688911
145MP0002160_abnormal_reproductive_system0.72517201
146MP0000230_abnormal_systemic_arterial0.72110999
147MP0002972_abnormal_cardiac_muscle0.72044123
148MP0005084_abnormal_gallbladder_morpholo0.71514145
149MP0009046_muscle_twitch0.71333147
150MP0005310_abnormal_salivary_gland0.70154195
151MP0008004_abnormal_stomach_pH0.69866057
152MP0001502_abnormal_circadian_rhythm0.69207726
153MP0005248_abnormal_Harderian_gland0.68567437
154MP0002060_abnormal_skin_morphology0.68555986
155MP0003705_abnormal_hypodermis_morpholog0.67450721
156MP0003566_abnormal_cell_adhesion0.67021892
157MP0000749_muscle_degeneration0.66808536
158MP0009278_abnormal_bone_marrow0.66678269
159MP0008872_abnormal_physiological_respon0.66392991
160MP0002736_abnormal_nociception_after0.65742502
161MP0002249_abnormal_larynx_morphology0.64251687
162MP0005257_abnormal_intraocular_pressure0.64101450
163MP0001944_abnormal_pancreas_morphology0.63848799
164MP0008775_abnormal_heart_ventricle0.63808945
165MP0005408_hypopigmentation0.63479823
166MP0002557_abnormal_social/conspecific_i0.61875199
167MP0001299_abnormal_eye_distance/0.60918478
168MP0000747_muscle_weakness0.59081465
169MP0000026_abnormal_inner_ear0.59079723
170MP0003634_abnormal_glial_cell0.58853839
171MP0002295_abnormal_pulmonary_circulatio0.58652550

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.37018395
2Abnormal respiratory epithelium morphology (HP:0012253)9.37018395
3Abnormal respiratory motile cilium physiology (HP:0012261)9.19238382
4Abnormal ciliary motility (HP:0012262)8.82813896
5Absent/shortened dynein arms (HP:0200106)8.63108922
6Dynein arm defect of respiratory motile cilia (HP:0012255)8.63108922
7Rhinitis (HP:0012384)8.55742904
8Chronic bronchitis (HP:0004469)6.94836276
9Bronchiectasis (HP:0002110)5.96951346
10Nasal polyposis (HP:0100582)5.81092912
11Eczematoid dermatitis (HP:0000976)5.36853497
12Recurrent gram-negative bacterial infections (HP:0005420)5.25655718
13Abnormality of the nasal mucosa (HP:0000433)4.88328949
14Recurrent abscess formation (HP:0002722)4.84697991
15Recurrent bacterial skin infections (HP:0005406)4.67267515
16Abnormality of macrophages (HP:0004311)3.95779001
17Male infertility (HP:0003251)3.69160532
18Infertility (HP:0000789)3.63983655
19Hypokalemic alkalosis (HP:0001949)3.61795151
20Vacuolated lymphocytes (HP:0001922)3.59891098
21Axonal loss (HP:0003447)3.58007866
22Metabolic alkalosis (HP:0200114)3.56598235
23Gout (HP:0001997)3.55516059
24Abnormality of glutamine family amino acid metabolism (HP:0010902)3.55316602
25Hyperactive renin-angiotensin system (HP:0000841)3.52357915
26Systemic lupus erythematosus (HP:0002725)3.37258428
27Recurrent sinusitis (HP:0011108)3.32581830
28Bronchitis (HP:0012387)3.23795570
29Recurrent otitis media (HP:0000403)3.20194403
30Increased circulating renin level (HP:0000848)3.18143823
31Abnormality of purine metabolism (HP:0004352)3.15767338
32Occipital encephalocele (HP:0002085)3.15487408
33Autoimmune thrombocytopenia (HP:0001973)3.14795550
34Abnormality of chloride homeostasis (HP:0011422)3.13721731
35Atelectasis (HP:0100750)3.10295689
36Mediastinal lymphadenopathy (HP:0100721)3.09878638
37Gingivitis (HP:0000230)3.06311413
38Polyuria (HP:0000103)3.03025918
39Abnormality of fatty-acid metabolism (HP:0004359)2.97384825
40Chronic sinusitis (HP:0011109)2.96122092
41Hypomagnesemia (HP:0002917)2.93516215
42Proximal tubulopathy (HP:0000114)2.93136273
43Abnormal urine output (HP:0012590)2.92304057
44Generalized aminoaciduria (HP:0002909)2.87309327
45Hyperglycinuria (HP:0003108)2.85910152
46Alkalosis (HP:0001948)2.85665062
47Nausea (HP:0002018)2.78711106
48Abnormality of renal excretion (HP:0011036)2.77292371
49Abnormality of magnesium homeostasis (HP:0004921)2.76323025
50Hand muscle atrophy (HP:0009130)2.66143112
51Xanthomatosis (HP:0000991)2.64010139
52Abnormality of proline metabolism (HP:0010907)2.62675629
53Hydroxyprolinuria (HP:0003080)2.62675629
54Urticaria (HP:0001025)2.62205003
55Increased purine levels (HP:0004368)2.61164753
56Hyperuricemia (HP:0002149)2.61164753
57Tetany (HP:0001281)2.59238209
58Recurrent skin infections (HP:0001581)2.58547100
59Ketoacidosis (HP:0001993)2.57280088
60Stomatitis (HP:0010280)2.54800511
61Joint hemorrhage (HP:0005261)2.47836024
62Ketosis (HP:0001946)2.46018424
63Abnormality of aromatic amino acid family metabolism (HP:0004338)2.46001418
64Obstructive lung disease (HP:0006536)2.45377183
65Chronic obstructive pulmonary disease (HP:0006510)2.45377183
66Neoplasm of head and neck (HP:0012288)2.44974884
67Esophageal neoplasm (HP:0100751)2.44974884
68Abnormality of nucleobase metabolism (HP:0010932)2.43966717
69Abnormality of urine glucose concentration (HP:0011016)2.42540746
70Glycosuria (HP:0003076)2.42540746
71Hyperaldosteronism (HP:0000859)2.42041056
72Tetraparesis (HP:0002273)2.31897724
73Polydipsia (HP:0001959)2.30527177
74Abnormal drinking behavior (HP:0030082)2.30527177
75Pancreatic fibrosis (HP:0100732)2.30356138
76Elevated erythrocyte sedimentation rate (HP:0003565)2.28088958
77Increased cerebral lipofuscin (HP:0011813)2.26815172
78True hermaphroditism (HP:0010459)2.25627755
79Distal upper limb amyotrophy (HP:0007149)2.25176904
80Upper limb amyotrophy (HP:0009129)2.25176904
81Abnormality of serine family amino acid metabolism (HP:0010894)2.24436877
82Abnormality of glycine metabolism (HP:0010895)2.24436877
83Renal salt wasting (HP:0000127)2.22768052
84Hyperammonemia (HP:0001987)2.20282280
85Dysostosis multiplex (HP:0000943)2.18781340
86Abnormality of dicarboxylic acid metabolism (HP:0010995)2.14398125
87Dicarboxylic aciduria (HP:0003215)2.14398125
88Abnormality of renin-angiotensin system (HP:0000847)2.13764627
89Distal lower limb muscle weakness (HP:0009053)2.13226360
90Vomiting (HP:0002013)2.12946761
91Acute encephalopathy (HP:0006846)2.09455757
92Conjunctival hamartoma (HP:0100780)2.08993208
93Hepatocellular necrosis (HP:0001404)2.08853861
94Glomerulonephritis (HP:0000099)2.08812320
95Vascular calcification (HP:0004934)2.07501174
96Cerebral edema (HP:0002181)2.07279377
97Increased neuronal autofluorescent lipopigment (HP:0002074)2.06476632
98Interstitial pulmonary disease (HP:0006530)2.03627705
99Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.03340708
100Decreased activity of mitochondrial respiratory chain (HP:0008972)2.03340708
101Hypophosphatemia (HP:0002148)2.02428600
102Orchitis (HP:0100796)2.00252660
103Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.8046106
104Cystic liver disease (HP:0006706)1.99236293
105Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.97868524
106Mitochondrial inheritance (HP:0001427)1.96629922
107Hyperphosphaturia (HP:0003109)1.95274464
108Myositis (HP:0100614)1.95062328
109Nephritis (HP:0000123)1.94692734
110Metabolic acidosis (HP:0001942)1.94511538
111Renal tubular acidosis (HP:0001947)1.94415506
112Urinary glycosaminoglycan excretion (HP:0003541)1.89978317
113Mucopolysacchariduria (HP:0008155)1.89978317
114Bell-shaped thorax (HP:0001591)1.87249182
115Lethargy (HP:0001254)1.87240460
116Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.86549251
117Pustule (HP:0200039)1.86150796
118Sensorimotor neuropathy (HP:0007141)1.85925382
119Cardiovascular calcification (HP:0011915)1.84936488
120Recurrent fungal infections (HP:0002841)1.84918882
121Chronic otitis media (HP:0000389)1.84590396
122Hepatic necrosis (HP:0002605)1.82916039
123Complement deficiency (HP:0004431)1.82433098
124Abnormal mitochondria in muscle tissue (HP:0008316)1.80343437
125Limb-girdle muscle atrophy (HP:0003797)1.80299677
126Myokymia (HP:0002411)1.79837230
127Abnormal urine phosphate concentration (HP:0012599)1.78136137
128Abnormality of aspartate family amino acid metabolism (HP:0010899)1.77725469
129Molar tooth sign on MRI (HP:0002419)1.76907312
130Abnormality of midbrain morphology (HP:0002418)1.76907312
131Myocardial infarction (HP:0001658)1.76035525
132Abnormality of monocarboxylic acid metabolism (HP:0010996)1.75278782
133Postaxial foot polydactyly (HP:0001830)1.74901604
134Acute necrotizing encephalopathy (HP:0006965)1.73583065
135Amyloidosis (HP:0011034)1.73318856
136Thick nail (HP:0001805)1.72674891
137Bone cyst (HP:0012062)1.72363305
138Abnormality of glycosaminoglycan metabolism (HP:0004371)1.71858061
139Growth hormone excess (HP:0000845)1.70583376
140Abnormal gallbladder physiology (HP:0012438)1.70569271
141Cholecystitis (HP:0001082)1.70569271
142Progressive macrocephaly (HP:0004481)1.70333111
143Stridor (HP:0010307)1.65444314
144Abnormality of the distal phalanges of the toes (HP:0010182)1.65196849
145Hyponatremia (HP:0002902)1.64958681
146Abnormality of dentin (HP:0010299)1.64926257
147Exercise intolerance (HP:0003546)1.63199532
148Nephronophthisis (HP:0000090)1.56945182
149Increased CSF lactate (HP:0002490)1.55533521
150Pancreatic cysts (HP:0001737)1.53973037
151Medial flaring of the eyebrow (HP:0010747)1.53430572
152Gait imbalance (HP:0002141)1.51763946
153Increased intramyocellular lipid droplets (HP:0012240)1.49779920
154Decreased circulating renin level (HP:0003351)1.47725655
155Nephropathy (HP:0000112)1.47472103
156Congenital primary aphakia (HP:0007707)1.46334724
157Glucose intolerance (HP:0000833)1.44898193
158Respiratory failure (HP:0002878)1.43784818
159Diaphragmatic weakness (HP:0009113)1.42893421
160Fetal akinesia sequence (HP:0001989)1.41942447
161Spinal cord compression (HP:0002176)1.40686848
162Sclerocornea (HP:0000647)1.39988467
163Male pseudohermaphroditism (HP:0000037)1.39165657
164Rough bone trabeculation (HP:0100670)1.39147109
165Craniofacial dystonia (HP:0012179)1.38968737
166Short nail (HP:0001799)1.37964837
167Aplasia of the musculature (HP:0100854)1.36992055
168Popliteal pterygium (HP:0009756)1.36727788
169Focal dystonia (HP:0004373)1.35745927
170Increased muscle lipid content (HP:0009058)1.34830530
171Torticollis (HP:0000473)1.32890371
172Aplasia/Hypoplasia of the tongue (HP:0010295)1.32784934
173Nuclear cataract (HP:0100018)1.31921185
174Abnormality of glycolysis (HP:0004366)1.29532422
175Anencephaly (HP:0002323)1.28870378
176Nephrogenic diabetes insipidus (HP:0009806)1.27041765
177Abnormality of sodium homeostasis (HP:0010931)1.26070983
178Renal Fanconi syndrome (HP:0001994)1.25500694
179Congenital hepatic fibrosis (HP:0002612)1.25024436
180Aplasia/Hypoplasia of the spleen (HP:0010451)1.24347516
181Hypokinesia (HP:0002375)1.23164106
182Increased serum pyruvate (HP:0003542)1.21259668
183Testicular atrophy (HP:0000029)1.20120761
184Furrowed tongue (HP:0000221)1.19744610
185Asplenia (HP:0001746)1.19461463
186Myopathic facies (HP:0002058)1.18430408
187Oculomotor apraxia (HP:0000657)1.17125514
188Hypotension (HP:0002615)1.17050386

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.25624756
2MAPK154.99211133
3RIPK44.76976492
4BLK3.00402072
5ERN12.84791139
6MAP3K142.79625999
7WNK42.77716848
8WNK32.74695282
9NME12.72264891
10LIMK12.70796393
11VRK22.63928876
12TBK12.52101944
13IRAK32.45813438
14MAP3K122.35768525
15TESK22.35266090
16PBK2.26426762
17BCKDK2.19265780
18MST1R2.13186374
19IRAK42.08578668
20OXSR12.05900522
21STK161.84158179
22TYK21.80672971
23ARAF1.80539340
24PIM21.70893665
25TRIB31.62654206
26NME21.62140195
27IKBKE1.57619024
28PAK41.55030645
29SMG11.54092682
30ABL21.52901210
31MYLK1.51505537
32MAP3K111.30920547
33MAP2K71.29651299
34PDK21.28368204
35ILK1.27665362
36FGR1.22504113
37JAK11.22425596
38NTRK11.20391999
39PRKCI1.19913704
40MST41.19429279
41PDK31.18548431
42PDK41.18548431
43TTN1.17485814
44CSK1.16281728
45PHKG11.13784342
46PHKG21.13784342
47MAP3K131.12869696
48CAMK2G1.10349603
49FGFR41.09938355
50GRK51.08059193
51NEK91.05014879
52TESK11.04681045
53KDR1.04505248
54IKBKB1.04243608
55GRK71.03782934
56BCR1.01547441
57RIPK11.01398012
58EPHB20.96694718
59MAP3K50.95383427
60KIT0.94221646
61SYK0.93628138
62KSR20.93114216
63PDPK10.92996037
64BMX0.90449857
65JAK20.88207824
66MAP4K10.85092263
67EPHB10.83821636
68DAPK20.83752225
69MAP3K30.82562416
70MAP3K10.82313423
71MET0.80688119
72AURKA0.80086467
73BMPR20.79038332
74TXK0.78406250
75PTK20.78098792
76PRKCD0.78022889
77ZAP700.77332727
78LRRK20.76990713
79PINK10.75769794
80MUSK0.75535694
81GRK60.75490290
82CDK190.75142602
83JAK30.73145944
84PRKD30.72412101
85DAPK30.72286946
86MAP2K30.70573056
87HCK0.70067803
88CSNK1G30.69174539
89PTK2B0.69098690
90PDK10.68432112
91PAK10.67860710
92DYRK20.67720144
93ROCK20.65997888
94TRPM70.65057014
95LMTK20.64012635
96PIK3CG0.62382270
97BRAF0.61766589
98MATK0.61354940
99MAP3K20.60688398
100EPHA40.60629928
101FER0.60267424
102AKT20.59766988
103TTK0.59690803
104ERBB40.59550830
105FES0.59128868
106LYN0.58055826
107MAP2K40.57766683
108TAOK10.56802053
109CSNK1G20.55609928
110STK38L0.52876489
111MARK30.52745013
112EIF2AK10.51695954
113IRAK10.50236669
114PRKG20.49917974
115MINK10.49839953
116PKN20.49773125
117MAP2K20.49543975
118ROCK10.48763213
119TAOK20.48713227
120STK380.48405628
121CAMK2D0.47676714
122MAP3K90.46113482
123DYRK1B0.44498985
124NEK10.44038084
125MARK20.43614964
126MAP2K10.42979571
127LATS20.42587771
128SIK30.41944711
129EGFR0.41199452
130BTK0.41122109
131PIM10.40168202
132MAP2K60.39797351
133MAPKAPK30.39218324
134PTK60.38813454
135STK240.37997502
136CSNK1A1L0.37673314
137ADRBK10.37632562
138EEF2K0.37609289
139PRKCZ0.36811442
140MAPK40.36405646
141DAPK10.35996522
142CAMK2B0.35658475
143MAPK120.35539431
144MAPK110.35528123
145IRAK20.35461523
146STK390.34909640
147PAK60.34437733
148ABL10.33555794
149PRKACG0.33224349
150TGFBR20.32408018
151CAMK2A0.31876958
152TLK10.31848195
153PRKD20.31454700
154PRKD10.29065564
155ICK0.28205643
156PRKCA0.27906370
157CSNK1G10.27504524
158UHMK10.26529296
159STK100.25808831
160RPS6KB20.25288064
161SIK10.25261683
162MARK10.24866256
163CDK140.24461742

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030502.68353754
2Staphylococcus aureus infection_Homo sapiens_hsa051502.67590915
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.59746581
4Collecting duct acid secretion_Homo sapiens_hsa049662.33833328
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.04782633
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.98362162
7Oxidative phosphorylation_Homo sapiens_hsa001901.97972374
8Leishmaniasis_Homo sapiens_hsa051401.97818086
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.86324038
10Rheumatoid arthritis_Homo sapiens_hsa053231.83462337
11Pentose and glucuronate interconversions_Homo sapiens_hsa000401.82089504
12Fatty acid degradation_Homo sapiens_hsa000711.81578842
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.78204376
14Propanoate metabolism_Homo sapiens_hsa006401.77788086
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.76585241
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.71348246
17Graft-versus-host disease_Homo sapiens_hsa053321.69683009
18* Peroxisome_Homo sapiens_hsa041461.67980161
19Arginine biosynthesis_Homo sapiens_hsa002201.65580387
20Legionellosis_Homo sapiens_hsa051341.59801674
21Butanoate metabolism_Homo sapiens_hsa006501.56828291
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.52971027
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.52485015
24Phagosome_Homo sapiens_hsa041451.48228911
25Tryptophan metabolism_Homo sapiens_hsa003801.46399077
26Tuberculosis_Homo sapiens_hsa051521.46187395
27Lysosome_Homo sapiens_hsa041421.44740074
28Pertussis_Homo sapiens_hsa051331.43199077
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.41198652
30beta-Alanine metabolism_Homo sapiens_hsa004101.36746647
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.35500499
32Carbon metabolism_Homo sapiens_hsa012001.33270340
33Parkinsons disease_Homo sapiens_hsa050121.32963280
34PPAR signaling pathway_Homo sapiens_hsa033201.32319839
35Sulfur relay system_Homo sapiens_hsa041221.30658970
36Galactose metabolism_Homo sapiens_hsa000521.29619777
37Pyruvate metabolism_Homo sapiens_hsa006201.29391480
38Complement and coagulation cascades_Homo sapiens_hsa046101.24193510
39Phenylalanine metabolism_Homo sapiens_hsa003601.24016115
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22879363
41Ribosome_Homo sapiens_hsa030101.16828115
42Fatty acid metabolism_Homo sapiens_hsa012121.16424203
43Salmonella infection_Homo sapiens_hsa051321.15762487
44Histidine metabolism_Homo sapiens_hsa003401.14078331
45Other glycan degradation_Homo sapiens_hsa005111.11668189
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.11600675
47Alzheimers disease_Homo sapiens_hsa050101.10011412
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.06643937
49Osteoclast differentiation_Homo sapiens_hsa043801.06014957
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.03805842
51Malaria_Homo sapiens_hsa051441.03640348
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02853962
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01687518
54Mineral absorption_Homo sapiens_hsa049780.99371421
55Starch and sucrose metabolism_Homo sapiens_hsa005000.99340869
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97320994
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.96152261
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95946690
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93221691
60Protein export_Homo sapiens_hsa030600.91849892
61Sulfur metabolism_Homo sapiens_hsa009200.91108187
62Metabolic pathways_Homo sapiens_hsa011000.90853024
63Type I diabetes mellitus_Homo sapiens_hsa049400.90621887
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89477830
65African trypanosomiasis_Homo sapiens_hsa051430.89178346
66Asthma_Homo sapiens_hsa053100.88897641
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86912231
68Vitamin digestion and absorption_Homo sapiens_hsa049770.86644641
69Steroid biosynthesis_Homo sapiens_hsa001000.85584494
70Caffeine metabolism_Homo sapiens_hsa002320.84651453
71Glutathione metabolism_Homo sapiens_hsa004800.84643794
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84462615
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84270464
74Tight junction_Homo sapiens_hsa045300.84244432
75Bile secretion_Homo sapiens_hsa049760.84155667
76Synaptic vesicle cycle_Homo sapiens_hsa047210.81299821
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81214591
78Chemical carcinogenesis_Homo sapiens_hsa052040.78543191
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76977475
80TNF signaling pathway_Homo sapiens_hsa046680.76556699
81N-Glycan biosynthesis_Homo sapiens_hsa005100.76390020
82Vibrio cholerae infection_Homo sapiens_hsa051100.75895911
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.75345252
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74392810
85Sphingolipid metabolism_Homo sapiens_hsa006000.72963309
86Allograft rejection_Homo sapiens_hsa053300.69983760
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69929351
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68866563
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67961428
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65899961
91Pentose phosphate pathway_Homo sapiens_hsa000300.65831670
92Fructose and mannose metabolism_Homo sapiens_hsa000510.65495598
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.64655457
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63238242
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62730210
96Amoebiasis_Homo sapiens_hsa051460.61046766
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.60467984
98Cardiac muscle contraction_Homo sapiens_hsa042600.60042665
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59868181
100Vitamin B6 metabolism_Homo sapiens_hsa007500.59261536
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57452990
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.56129283
103Influenza A_Homo sapiens_hsa051640.55551935
104Fatty acid elongation_Homo sapiens_hsa000620.53099861
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52702716
106Arachidonic acid metabolism_Homo sapiens_hsa005900.52697839
107Huntingtons disease_Homo sapiens_hsa050160.52414272
108Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51993458
109Tyrosine metabolism_Homo sapiens_hsa003500.51577272
110Folate biosynthesis_Homo sapiens_hsa007900.51307290
111Arginine and proline metabolism_Homo sapiens_hsa003300.51245199
112Pyrimidine metabolism_Homo sapiens_hsa002400.48716418
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48700938
114Prion diseases_Homo sapiens_hsa050200.48181527
115Nitrogen metabolism_Homo sapiens_hsa009100.47006080
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46913004
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.46140943
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45919705
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45895364
120Biosynthesis of amino acids_Homo sapiens_hsa012300.45261603
121Glycerolipid metabolism_Homo sapiens_hsa005610.44429096
122Toxoplasmosis_Homo sapiens_hsa051450.43038101
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42489965
124Purine metabolism_Homo sapiens_hsa002300.42089561
125Retinol metabolism_Homo sapiens_hsa008300.41443698
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40791913
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.40250631
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40124510
129Chemokine signaling pathway_Homo sapiens_hsa040620.40020626
130Measles_Homo sapiens_hsa051620.39492174
131Salivary secretion_Homo sapiens_hsa049700.37105732
132Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36392725
133RNA polymerase_Homo sapiens_hsa030200.35254832
134Cocaine addiction_Homo sapiens_hsa050300.34801213
135Base excision repair_Homo sapiens_hsa034100.29929740
136Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29006349
137Dilated cardiomyopathy_Homo sapiens_hsa054140.28642722
138Endocytosis_Homo sapiens_hsa041440.27483255

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