PREB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that specifically binds to a Pit1-binding element of the prolactin (PRL) promoter. This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing 1 (ABHD1) gene on the opposite strand. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.33555736
2L-phenylalanine catabolic process (GO:0006559)6.33555736
3L-phenylalanine metabolic process (GO:0006558)6.21485353
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.21485353
5regulation of plasminogen activation (GO:0010755)5.93472771
6folic acid-containing compound biosynthetic process (GO:0009396)5.79353253
7purine nucleotide salvage (GO:0032261)5.29087402
8aromatic amino acid family catabolic process (GO:0009074)5.24320918
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.20046216
10sulfur amino acid catabolic process (GO:0000098)5.10052522
11cysteine metabolic process (GO:0006534)5.07766531
12glyoxylate metabolic process (GO:0046487)4.91256378
13alpha-linolenic acid metabolic process (GO:0036109)4.86712112
14lysine catabolic process (GO:0006554)4.79604925
15lysine metabolic process (GO:0006553)4.79604925
16kynurenine metabolic process (GO:0070189)4.63207757
17tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.62214094
18RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.62214094
19L-serine metabolic process (GO:0006563)4.56175680
20galactose catabolic process (GO:0019388)4.54960348
21fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.47321585
22negative regulation of fibrinolysis (GO:0051918)4.47022958
23bile acid biosynthetic process (GO:0006699)4.42381564
24tryptophan catabolic process (GO:0006569)4.42073860
25indole-containing compound catabolic process (GO:0042436)4.42073860
26indolalkylamine catabolic process (GO:0046218)4.42073860
27high-density lipoprotein particle remodeling (GO:0034375)4.35340635
28urea cycle (GO:0000050)4.28495443
29urea metabolic process (GO:0019627)4.28495443
30regulation of cholesterol homeostasis (GO:2000188)4.24183082
31serine family amino acid catabolic process (GO:0009071)4.20271778
32tryptophan metabolic process (GO:0006568)4.17898513
33peptidyl-glutamic acid carboxylation (GO:0017187)4.17451266
34protein carboxylation (GO:0018214)4.17451266
35homocysteine metabolic process (GO:0050667)4.14925862
36complement activation, alternative pathway (GO:0006957)4.12285767
37glycine metabolic process (GO:0006544)4.11944557
38regulation of triglyceride catabolic process (GO:0010896)4.11918519
39proline biosynthetic process (GO:0006561)4.10727341
40regulation of protein activation cascade (GO:2000257)4.10326317
41pteridine-containing compound biosynthetic process (GO:0042559)4.09488232
42peptidyl-arginine omega-N-methylation (GO:0035247)4.08535435
43nucleotide salvage (GO:0043173)4.08511912
44cellular modified amino acid catabolic process (GO:0042219)4.04873183
45intestinal cholesterol absorption (GO:0030299)4.04511183
46valine metabolic process (GO:0006573)4.02624575
47regulation of fibrinolysis (GO:0051917)3.99707731
48reverse cholesterol transport (GO:0043691)3.97963807
49serine family amino acid metabolic process (GO:0009069)3.91594847
50nitrogen cycle metabolic process (GO:0071941)3.91427123
51bile acid metabolic process (GO:0008206)3.90618173
52negative regulation of sterol transport (GO:0032372)3.87872579
53negative regulation of cholesterol transport (GO:0032375)3.87872579
54proline metabolic process (GO:0006560)3.87093726
55serine family amino acid biosynthetic process (GO:0009070)3.85085703
56amino-acid betaine metabolic process (GO:0006577)3.85024343
57regulation of complement activation (GO:0030449)3.84444891
58phospholipid efflux (GO:0033700)3.82774347
59alpha-amino acid catabolic process (GO:1901606)3.80007507
60GDP-mannose metabolic process (GO:0019673)3.78716173
61triglyceride homeostasis (GO:0070328)3.78056120
62acylglycerol homeostasis (GO:0055090)3.78056120
63aromatic amino acid family metabolic process (GO:0009072)3.77926463
64COPI coating of Golgi vesicle (GO:0048205)3.77261129
65Golgi transport vesicle coating (GO:0048200)3.77261129
662-oxoglutarate metabolic process (GO:0006103)3.76557718
67negative regulation of cell size (GO:0045792)3.75652404
68plasma lipoprotein particle remodeling (GO:0034369)3.75029938
69protein-lipid complex remodeling (GO:0034368)3.75029938
70macromolecular complex remodeling (GO:0034367)3.75029938
714-hydroxyproline metabolic process (GO:0019471)3.69084629
72IMP biosynthetic process (GO:0006188)3.66546352
73cellular amino acid catabolic process (GO:0009063)3.66472782
74mitochondrial RNA metabolic process (GO:0000959)3.64734397
75tricarboxylic acid metabolic process (GO:0072350)3.64626086
76regulation of cholesterol esterification (GO:0010872)3.64384362
77drug transmembrane transport (GO:0006855)3.64297284
78folic acid-containing compound metabolic process (GO:0006760)3.61996491
79ethanol oxidation (GO:0006069)3.60423728
80NADH metabolic process (GO:0006734)3.60361750
81negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.59257694
82glutamate metabolic process (GO:0006536)3.54395214
83bile acid and bile salt transport (GO:0015721)3.53699018
84aspartate family amino acid catabolic process (GO:0009068)3.53544351
85regulation of superoxide anion generation (GO:0032928)3.52136644
86plasma lipoprotein particle clearance (GO:0034381)3.50437058
87regulation of cholesterol storage (GO:0010885)3.50189403
88protein maturation by protein folding (GO:0022417)3.50044668
89folic acid metabolic process (GO:0046655)3.48385903
90plasma lipoprotein particle assembly (GO:0034377)3.46615328
91fatty acid beta-oxidation (GO:0006635)3.44243481
92coenzyme catabolic process (GO:0009109)3.43761669
93tetrahydrofolate metabolic process (GO:0046653)3.43446608
94positive regulation of lipoprotein lipase activity (GO:0051006)3.42107534
95positive regulation of triglyceride lipase activity (GO:0061365)3.42107534
96short-chain fatty acid metabolic process (GO:0046459)3.41888481
97galactose metabolic process (GO:0006012)3.41809028
98fatty acid oxidation (GO:0019395)3.40434893
99positive regulation of triglyceride metabolic process (GO:0090208)3.39716716
100tyrosine metabolic process (GO:0006570)3.36113099
101ribosome biogenesis (GO:0042254)3.35735320
102positive regulation of fatty acid biosynthetic process (GO:0045723)3.35379617
103IMP metabolic process (GO:0046040)3.35186344
104desmosome organization (GO:0002934)3.34356179
105fatty acid catabolic process (GO:0009062)3.34287273
106lipid oxidation (GO:0034440)3.33837686
107phospholipid homeostasis (GO:0055091)3.32729958
108monocarboxylic acid catabolic process (GO:0072329)3.32722220
109carboxylic acid catabolic process (GO:0046395)3.31882019
110organic acid catabolic process (GO:0016054)3.31882019
111regulation of vitamin D biosynthetic process (GO:0060556)3.28168132
112glycosphingolipid catabolic process (GO:0046479)3.27928664
113cholesterol homeostasis (GO:0042632)3.27419726
114maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.26465275
115cellular glucuronidation (GO:0052695)3.25759728
116flavonoid metabolic process (GO:0009812)3.25237882
117protein-lipid complex assembly (GO:0065005)3.24504765
118benzene-containing compound metabolic process (GO:0042537)3.24293330
119acetyl-CoA metabolic process (GO:0006084)3.22434023
120sterol homeostasis (GO:0055092)3.22192418
121response to vitamin A (GO:0033189)3.21317151
122cellular ketone body metabolic process (GO:0046950)3.19426937
123protein retention in ER lumen (GO:0006621)3.19381776
124urate metabolic process (GO:0046415)3.18819952
125imidazole-containing compound metabolic process (GO:0052803)3.17821878
126intestinal absorption (GO:0050892)3.17452650
127cholesterol efflux (GO:0033344)3.17246120
128peptidyl-arginine methylation (GO:0018216)3.16285927
129peptidyl-arginine N-methylation (GO:0035246)3.16285927
130drug transport (GO:0015893)3.16252921
131pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.14355136
132regulation of cholesterol metabolic process (GO:0090181)3.14191651
133drug catabolic process (GO:0042737)3.13615285
134peptidyl-proline hydroxylation (GO:0019511)3.13595087
135oxaloacetate metabolic process (GO:0006107)3.13589435
136histone arginine methylation (GO:0034969)3.11741996
137phosphatidylglycerol biosynthetic process (GO:0006655)3.11255795
138aminoglycoside antibiotic metabolic process (GO:0030647)3.09149799
139glycoside metabolic process (GO:0016137)3.05531142
140regulation of mammary gland epithelial cell proliferation (GO:0033599)3.04741851
141microtubule nucleation (GO:0007020)3.04307450
142regulation of vitamin metabolic process (GO:0030656)3.02578137
143glycolipid catabolic process (GO:0019377)3.01137081
144deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.01099742
145white fat cell differentiation (GO:0050872)3.00571977
146pteridine-containing compound metabolic process (GO:0042558)2.99392390
147guanosine-containing compound biosynthetic process (GO:1901070)2.99172250
148negative regulation of necroptotic process (GO:0060546)2.98518481
149monosaccharide biosynthetic process (GO:0046364)2.97192707
150alpha-amino acid biosynthetic process (GO:1901607)2.95095608
151polyamine biosynthetic process (GO:0006596)2.94799091
152negative regulation of DNA biosynthetic process (GO:2000279)2.91680109
153gluconeogenesis (GO:0006094)2.88672297
154pentose-phosphate shunt (GO:0006098)2.88515317
155hexose biosynthetic process (GO:0019319)2.79648658
156retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.79083984
157cellular protein complex localization (GO:0034629)2.71912742
158nucleoside transmembrane transport (GO:1901642)2.71016232
159pentose metabolic process (GO:0019321)2.69443483
160mitochondrial fusion (GO:0008053)2.68834107
161pinocytosis (GO:0006907)2.66555353
162pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.65780413
163tRNA modification (GO:0006400)2.65569478
164transcription from mitochondrial promoter (GO:0006390)2.64040591
165response to thyroid hormone (GO:0097066)2.60817492
166regulation of tight junction assembly (GO:2000810)2.60186249
167glutamine family amino acid biosynthetic process (GO:0009084)2.58831831
168NADPH regeneration (GO:0006740)2.58303680
169cellular modified amino acid biosynthetic process (GO:0042398)2.56902983
170adenosine metabolic process (GO:0046085)2.55097111
171pyrimidine nucleotide catabolic process (GO:0006244)2.54769772
172glucose catabolic process (GO:0006007)2.52873623
173protein hydroxylation (GO:0018126)2.52242782
174sulfur amino acid biosynthetic process (GO:0000097)2.51256762
175ceramide catabolic process (GO:0046514)2.49939131
176negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.49500925
177negative regulation of catenin import into nucleus (GO:0035414)2.48722216
178cell migration involved in heart development (GO:0060973)2.47112176
179pseudouridine synthesis (GO:0001522)2.45963051

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.41736902
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.85584508
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.39763695
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.76280047
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.42417379
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.59890319
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.56160672
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.53656446
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.42628698
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.21469198
11E2F7_22180533_ChIP-Seq_HELA_Human2.92588071
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.75484004
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.71278702
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.41200527
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.37205009
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.29452934
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.21911588
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.20937139
19GATA1_22025678_ChIP-Seq_K562_Human2.08321210
20CLOCK_20551151_ChIP-Seq_293T_Human2.06926540
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.00148224
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.93766976
23DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.87578542
24MYC_22102868_ChIP-Seq_BL_Human1.80557212
25LXR_22292898_ChIP-Seq_THP-1_Human1.77825645
26* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.76585248
27XRN2_22483619_ChIP-Seq_HELA_Human1.75118713
28CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.72837184
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.70882922
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.68993239
31MYC_19079543_ChIP-ChIP_MESCs_Mouse1.67592461
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.65319352
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.65047062
34VDR_21846776_ChIP-Seq_THP-1_Human1.63905381
35* GABP_19822575_ChIP-Seq_HepG2_Human1.60202655
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57743521
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57285284
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.54547435
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54538932
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.53626125
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.47774126
42KLF4_18555785_ChIP-Seq_MESCs_Mouse1.46427214
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40391580
44* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.40001548
45* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39126593
46TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.38702628
47SOX2_27498859_Chip-Seq_STOMACH_Mouse1.38644437
48ZNF263_19887448_ChIP-Seq_K562_Human1.38329715
49* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.36708466
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34141820
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33038273
52E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32490245
53RACK7_27058665_Chip-Seq_MCF-7_Human1.31838876
54SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26444134
55STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25446250
56DCP1A_22483619_ChIP-Seq_HELA_Human1.25157622
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24651400
58SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24454453
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.24185348
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21774635
61BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21103116
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20733735
63* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.20691579
64* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.20318871
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20218335
66CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.20052042
67FOXA2_19822575_ChIP-Seq_HepG2_Human1.19602374
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17407263
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16818737
70SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15321110
71PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14867323
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.14827581
73* ETS1_21867929_ChIP-Seq_TH2_Mouse1.13978245
74KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.13961425
75SCL_19346495_ChIP-Seq_HPC-7_Human1.13816549
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13643910
77ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12740342
78TCF7_22412390_ChIP-Seq_EML_Mouse1.11470520
79CREB1_15753290_ChIP-ChIP_HEK293T_Human1.11434223
80ESR1_21235772_ChIP-Seq_MCF-7_Human1.09796326
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09530018
82SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09443271
83* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09079761
84KDM5A_27292631_Chip-Seq_BREAST_Human1.08712372
85ATF3_27146783_Chip-Seq_COLON_Human1.08497691
86YY1_22570637_ChIP-Seq_MALME-3M_Human1.08455720
87MAF_26560356_Chip-Seq_TH1_Human1.08112677
88TP63_17297297_ChIP-ChIP_HaCaT_Human1.07850917
89CTCF_26484167_Chip-Seq_Bcells_Mouse1.07330474
90CIITA_25753668_ChIP-Seq_RAJI_Human1.06757130
91FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.04719046
92SMC4_20622854_ChIP-Seq_HELA_Human1.04309835
93GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04268129
94SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.04153810
95CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04051794
96HNF4A_19822575_ChIP-Seq_HepG2_Human1.03434722
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03307449
98ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02778287
99* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.02717291
100CTCF_18555785_ChIP-Seq_MESCs_Mouse1.02637770
101ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02419071
102* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01857210
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01786051
104UTX_26944678_Chip-Seq_JUKART_Human1.01755582
105GATA1_19941827_ChIP-Seq_MEL_Mouse1.01100457
106STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01100062
107FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.00087955
108STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99428825
109KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99040163
110P68_20966046_ChIP-Seq_HELA_Human0.98809498
111GATA4_25053715_ChIP-Seq_YYC3_Human0.98223451
112BCOR_27268052_Chip-Seq_Bcells_Human0.97755274
113TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95753481
114GATA6_25053715_ChIP-Seq_YYC3_Human0.95357413
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95205344
116VDR_24763502_ChIP-Seq_THP-1_Human0.94187286
117NCOR1_26117541_ChIP-Seq_K562_Human0.94144637
118ELF1_20517297_ChIP-Seq_JURKAT_Human0.93779303
119NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93146106
120TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92525230
121MYB_21317192_ChIP-Seq_ERMYB_Mouse0.91715202
122ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91399831
123TET1_21451524_ChIP-Seq_MESCs_Mouse0.90433912
124RXRA_24833708_ChIP-Seq_LIVER_Mouse0.90169049
125KDM2B_26808549_Chip-Seq_DND41_Human0.89778808
126GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89714125
127ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88764046
128CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87797815
129NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.87610035
130BCL6_27268052_Chip-Seq_Bcells_Human0.87359164
131GATA1_19941826_ChIP-Seq_K562_Human0.86860909
132CREB1_26743006_Chip-Seq_LNCaP_Human0.86160645
133ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84725552
134* CTCF_21964334_Chip-Seq_Bcells_Human0.84109722
135* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.83682074
136PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.83347648
137KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83243613
138RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.83236061
139SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.82944842
140FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.82886429
141KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.82435503
142RARA_24833708_ChIP-Seq_LIVER_Mouse0.81923745
143TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.81717880
144MAF_26560356_Chip-Seq_TH2_Human0.80405365
145CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.80348014
146SA1_27219007_Chip-Seq_ERYTHROID_Human0.79528578
147SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.79375329
148RARB_24833708_ChIP-Seq_LIVER_Mouse0.79092856
149* RUNX1_22412390_ChIP-Seq_EML_Mouse0.78809406
150FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.76773473
151* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.76400937
152TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.76355194
153MYB_26560356_Chip-Seq_TH1_Human0.76016293
154CTCF_27219007_Chip-Seq_ERYTHROID_Human0.75611391
155ZFX_18555785_ChIP-Seq_MESCs_Mouse0.74122702
156PHF8_20622854_ChIP-Seq_HELA_Human0.74034970

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.52078998
2MP0005360_urolithiasis6.05551745
3MP0005365_abnormal_bile_salt5.31232875
4MP0005085_abnormal_gallbladder_physiolo4.79989899
5MP0008875_abnormal_xenobiotic_pharmacok3.59035144
6MP0009840_abnormal_foam_cell3.54533727
7MP0003806_abnormal_nucleotide_metabolis3.48207063
8MP0003252_abnormal_bile_duct3.39932968
9MP0005083_abnormal_biliary_tract3.16742726
10MP0001666_abnormal_nutrient_absorption3.08075091
11MP0010329_abnormal_lipoprotein_level2.97528283
12MP0004233_abnormal_muscle_weight2.58187284
13MP0005332_abnormal_amino_acid2.55676772
14MP0003191_abnormal_cellular_cholesterol2.49887384
15MP0003195_calcinosis2.36957442
16MP0000609_abnormal_liver_physiology2.13203346
17MP0008260_abnormal_autophagy2.10448148
18MP0002396_abnormal_hematopoietic_system2.05324809
19MP0002118_abnormal_lipid_homeostasis1.98138175
20MP0003868_abnormal_feces_composition1.92133576
21MP0000678_abnormal_parathyroid_gland1.87607789
22MP0002138_abnormal_hepatobiliary_system1.87224420
23MP0005319_abnormal_enzyme/_coenzyme1.83273336
24MP0009643_abnormal_urine_homeostasis1.82397249
25MP0004019_abnormal_vitamin_homeostasis1.81144785
26MP0003693_abnormal_embryo_hatching1.75228254
27MP0009333_abnormal_splenocyte_physiolog1.75194928
28MP0003705_abnormal_hypodermis_morpholog1.75038061
29MP0005220_abnormal_exocrine_pancreas1.72453326
30MP0000858_altered_metastatic_potential1.71494956
31MP0003300_gastrointestinal_ulcer1.61169061
32MP0003111_abnormal_nucleus_morphology1.61068303
33MP0005076_abnormal_cell_differentiation1.55859910
34MP0005058_abnormal_lysosome_morphology1.51210908
35MP0000751_myopathy1.48896716
36MP0008438_abnormal_cutaneous_collagen1.48208491
37MP0005584_abnormal_enzyme/coenzyme_acti1.40518818
38MP0001764_abnormal_homeostasis1.38829132
39MP0004858_abnormal_nervous_system1.38384306
40MP0002837_dystrophic_cardiac_calcinosis1.35916235
41MP0002132_abnormal_respiratory_system1.35158589
42MP0000750_abnormal_muscle_regeneration1.33265405
43MP0000598_abnormal_liver_morphology1.31203169
44MP0000759_abnormal_skeletal_muscle1.24014687
45MP0004264_abnormal_extraembryonic_tissu1.23686478
46MP0002078_abnormal_glucose_homeostasis1.21455866
47MP0006036_abnormal_mitochondrial_physio1.19641534
48MP0003656_abnormal_erythrocyte_physiolo1.19566212
49MP0003786_premature_aging1.18178598
50MP0005636_abnormal_mineral_homeostasis1.17248648
51MP0005670_abnormal_white_adipose1.17168211
52MP0004043_abnormal_pH_regulation1.14546422
53MP0001849_ear_inflammation1.11197557
54MP0001944_abnormal_pancreas_morphology1.10656247
55MP0001730_embryonic_growth_arrest1.10361674
56MP0005330_cardiomyopathy1.09393320
57MP0003436_decreased_susceptibility_to1.07305041
58MP0002693_abnormal_pancreas_physiology1.03228163
59MP0008469_abnormal_protein_level1.02784523
60MP0005084_abnormal_gallbladder_morpholo1.01844057
61MP0003186_abnormal_redox_activity1.00976329
62MP0000749_muscle_degeneration1.00675510
63MP0005646_abnormal_pituitary_gland1.00103759
64MP0009642_abnormal_blood_homeostasis0.98387018
65MP0005666_abnormal_adipose_tissue0.97812352
66MP0001756_abnormal_urination0.92381869
67MP0009763_increased_sensitivity_to0.92164363
68MP0000604_amyloidosis0.92124001
69MP0002928_abnormal_bile_duct0.91700961
70MP0003077_abnormal_cell_cycle0.90800354
71MP0005464_abnormal_platelet_physiology0.90427183
72MP0009115_abnormal_fat_cell0.89500366
73MP0001765_abnormal_ion_homeostasis0.89316084
74MP0008995_early_reproductive_senescence0.88078978
75MP0010094_abnormal_chromosome_stability0.87622877
76MP0005334_abnormal_fat_pad0.86368992
77MP0004087_abnormal_muscle_fiber0.85059897
78MP0002971_abnormal_brown_adipose0.84639159
79MP0000733_abnormal_muscle_development0.84512593
80MP0003646_muscle_fatigue0.84140639
81MP0006035_abnormal_mitochondrial_morpho0.84075631
82MP0010234_abnormal_vibrissa_follicle0.81821380
83MP0010368_abnormal_lymphatic_system0.81471743
84MP0000371_diluted_coat_color0.81176893
85MP0008932_abnormal_embryonic_tissue0.80923964
86MP0002909_abnormal_adrenal_gland0.79904112
87MP0002136_abnormal_kidney_physiology0.79002886
88MP0005375_adipose_tissue_phenotype0.77149934
89MP0004957_abnormal_blastocyst_morpholog0.76969814
90MP0004130_abnormal_muscle_cell0.76240320
91MP0000313_abnormal_cell_death0.75430067
92MP0001270_distended_abdomen0.74494398
93MP0003315_abnormal_perineum_morphology0.74349421
94MP0005501_abnormal_skin_physiology0.73856646
95MP0009764_decreased_sensitivity_to0.73834527
96MP0008058_abnormal_DNA_repair0.73676881
97MP0002269_muscular_atrophy0.72416601
98MP0000681_abnormal_thyroid_gland0.71144183
99MP0003763_abnormal_thymus_physiology0.71068396
100MP0005025_abnormal_response_to0.69634801
101MP0001845_abnormal_inflammatory_respons0.69559069
102MP0003638_abnormal_response/metabolism_0.69465772
103MP0005451_abnormal_body_composition0.69197853
104MP0002089_abnormal_postnatal_growth/wei0.69071677
105MP0004185_abnormal_adipocyte_glucose0.69066497
106MP0006054_spinal_hemorrhage0.68806567
107MP0010630_abnormal_cardiac_muscle0.68116412
108MP0005448_abnormal_energy_balance0.67959151
109MP0002722_abnormal_immune_system0.67716341
110MP0008961_abnormal_basal_metabolism0.67534501
111MP0000358_abnormal_cell_content/0.67388184
112MP0002970_abnormal_white_adipose0.67106315
113MP0003183_abnormal_peptide_metabolism0.66916094
114MP0003221_abnormal_cardiomyocyte_apopto0.66876378
115MP0000703_abnormal_thymus_morphology0.66687461
116MP0002419_abnormal_innate_immunity0.66354838
117MP0001853_heart_inflammation0.65996695
118MP0003953_abnormal_hormone_level0.64639408
119MP0000490_abnormal_crypts_of0.64335184
120MP0003011_delayed_dark_adaptation0.64297382
121MP0002429_abnormal_blood_cell0.64278193
122MP0009931_abnormal_skin_appearance0.63640385
123MP0003866_abnormal_defecation0.63314928
124MP0005023_abnormal_wound_healing0.63146850
125MP0009765_abnormal_xenobiotic_induced0.63068349
126MP0002877_abnormal_melanocyte_morpholog0.62830273
127MP0003566_abnormal_cell_adhesion0.62692381
128MP0004147_increased_porphyrin_level0.62615514
129MP0000343_altered_response_to0.61243767
130MP0005535_abnormal_body_temperature0.61221243
131MP0000013_abnormal_adipose_tissue0.60845131
132MP0002332_abnormal_exercise_endurance0.60736452
133MP0005376_homeostasis/metabolism_phenot0.60644232
134MP0003329_amyloid_beta_deposits0.59955239
135MP0002080_prenatal_lethality0.59516065
136MP0010155_abnormal_intestine_physiology0.58564008
137MP0000003_abnormal_adipose_tissue0.58543427
138MP0002019_abnormal_tumor_incidence0.58530363
139MP0005266_abnormal_metabolism0.55650081
140MP0009672_abnormal_birth_weight0.54986843
141MP0000747_muscle_weakness0.54150804
142MP0000639_abnormal_adrenal_gland0.53180958
143MP0003303_peritoneal_inflammation0.52918774
144MP0003075_altered_response_to0.52036445
145MP0001661_extended_life_span0.51937411
146MP0003172_abnormal_lysosome_physiology0.51597691
147MP0005647_abnormal_sex_gland0.50801349
148MP0004947_skin_inflammation0.50754731
149MP0001533_abnormal_skeleton_physiology0.49041169
150MP0009384_cardiac_valve_regurgitation0.48127027
151MP0002135_abnormal_kidney_morphology0.47452973
152MP0000230_abnormal_systemic_arterial0.46000301
153MP0003724_increased_susceptibility_to0.45974468
154MP0008873_increased_physiological_sensi0.44167280
155MP0000477_abnormal_intestine_morphology0.43774320

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.95369385
2Deep venous thrombosis (HP:0002625)5.35179950
3Intrahepatic cholestasis (HP:0001406)5.01107631
4Abnormality of monocarboxylic acid metabolism (HP:0010996)4.94040056
5Xanthomatosis (HP:0000991)4.91459236
6Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.91332953
7Abnormality of alanine metabolism (HP:0010916)4.91332953
8Hyperalaninemia (HP:0003348)4.91332953
9Hypoglycemic coma (HP:0001325)4.76177597
10Hypobetalipoproteinemia (HP:0003563)4.42961339
11Ketosis (HP:0001946)4.42463988
12Prolonged partial thromboplastin time (HP:0003645)4.10630715
13Myopathic facies (HP:0002058)3.94173527
14Hyperlipoproteinemia (HP:0010980)3.92040757
15Ketoacidosis (HP:0001993)3.90064565
16Abnormality of the common coagulation pathway (HP:0010990)3.87158473
17Hyperammonemia (HP:0001987)3.82809834
18Abnormality of the intrinsic pathway (HP:0010989)3.75319665
19Complement deficiency (HP:0004431)3.70563131
20Hyperglycinuria (HP:0003108)3.69139666
21Hyperglycinemia (HP:0002154)3.63172494
22Abnormality of glycine metabolism (HP:0010895)3.58937970
23Abnormality of serine family amino acid metabolism (HP:0010894)3.58937970
24Abnormality of glutamine family amino acid metabolism (HP:0010902)3.54347369
25Abnormality of glycolysis (HP:0004366)3.45294131
26Hypolipoproteinemia (HP:0010981)3.42613872
27Hyperinsulinemic hypoglycemia (HP:0000825)3.42203022
28Increased serum pyruvate (HP:0003542)3.42076141
29Abnormality of the fetal cardiovascular system (HP:0010948)3.41837775
30Abnormal umbilical cord blood vessels (HP:0011403)3.41837775
31Single umbilical artery (HP:0001195)3.41837775
32Abnormality of sulfur amino acid metabolism (HP:0004339)3.39864998
33Late onset (HP:0003584)3.33986267
34Abnormality of fatty-acid metabolism (HP:0004359)3.33388092
35Ragged-red muscle fibers (HP:0003200)3.29910508
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.28344309
37Joint hemorrhage (HP:0005261)3.22149400
38Gout (HP:0001997)3.19774667
39Fat malabsorption (HP:0002630)3.17069684
40Generalized aminoaciduria (HP:0002909)3.09101491
41Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.07872311
42Hypoglycemic seizures (HP:0002173)3.06818904
43Biconcave vertebral bodies (HP:0004586)3.04777660
44Hypoalphalipoproteinemia (HP:0003233)3.04721514
45Abnormality of the umbilical cord (HP:0010881)3.01179984
46Progressive muscle weakness (HP:0003323)3.00891917
47Fatigue (HP:0012378)2.95441227
48Abnormality of aspartate family amino acid metabolism (HP:0010899)2.90149758
49Rhabdomyolysis (HP:0003201)2.86159223
50Abnormality of purine metabolism (HP:0004352)2.85986589
51Abnormality of complement system (HP:0005339)2.80855530
52Epidermoid cyst (HP:0200040)2.78383767
53Hyperbilirubinemia (HP:0002904)2.75506288
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.73360580
55Dicarboxylic aciduria (HP:0003215)2.73360580
56Hypertensive crisis (HP:0100735)2.73314794
57Abnormality of nucleobase metabolism (HP:0010932)2.72983417
58Conjugated hyperbilirubinemia (HP:0002908)2.71894632
59Abnormal gallbladder physiology (HP:0012438)2.69780295
60Cholecystitis (HP:0001082)2.69780295
61Hypercholesterolemia (HP:0003124)2.69014142
62Vertebral compression fractures (HP:0002953)2.64753965
63Abnormality of methionine metabolism (HP:0010901)2.61567494
64Myocardial infarction (HP:0001658)2.50267448
65Skin nodule (HP:0200036)2.50088124
66Vacuolated lymphocytes (HP:0001922)2.49234139
67Abnormality of pyrimidine metabolism (HP:0004353)2.46977073
68Constricted visual fields (HP:0001133)2.46432583
69Metabolic acidosis (HP:0001942)2.45100893
70Spontaneous hematomas (HP:0007420)2.43461089
71Abnormality of endocrine pancreas physiology (HP:0012093)2.43391665
72Abnormality of the pancreatic islet cells (HP:0006476)2.43391665
73Oligomenorrhea (HP:0000876)2.43006921
74Delayed CNS myelination (HP:0002188)2.42270281
75Hyperglycemia (HP:0003074)2.38763942
76Anorexia (HP:0002039)2.36347586
77Symptomatic seizures (HP:0011145)2.35073152
78Microvesicular hepatic steatosis (HP:0001414)2.34325703
79Exercise-induced myalgia (HP:0003738)2.34119948
80Malnutrition (HP:0004395)2.32350285
81Abnormality of the tricuspid valve (HP:0001702)2.28137403
82Reduced subcutaneous adipose tissue (HP:0003758)2.28112525
83Menorrhagia (HP:0000132)2.27453193
84Mucopolysacchariduria (HP:0008155)2.24285766
85Urinary glycosaminoglycan excretion (HP:0003541)2.24285766
86Spastic diplegia (HP:0001264)2.23687591
87Abnormality of serum amino acid levels (HP:0003112)2.22931033
88Centrally nucleated skeletal muscle fibers (HP:0003687)2.22833374
89Steatorrhea (HP:0002570)2.18912012
90Hepatocellular carcinoma (HP:0001402)2.17767070
91Dysostosis multiplex (HP:0000943)2.14944309
92Pancreatitis (HP:0001733)2.13309954
93Mitral stenosis (HP:0001718)2.12773748
94Abnormality of polysaccharide metabolism (HP:0011012)2.12187371
95Abnormality of glycosaminoglycan metabolism (HP:0004371)2.12187371
96Abnormality of mucopolysaccharide metabolism (HP:0011020)2.12187371
97Nausea (HP:0002018)2.10854707
98White forelock (HP:0002211)2.09432496
99Insulin resistance (HP:0000855)2.08351448
100Proximal tubulopathy (HP:0000114)2.08273328
101Myoglobinuria (HP:0002913)2.07534480
102Back pain (HP:0003418)2.06942435
103Lethargy (HP:0001254)2.04793653
104Decreased subcutaneous fat (HP:0001002)2.04025192
105Hydroxyprolinuria (HP:0003080)2.03760601
106Abnormality of proline metabolism (HP:0010907)2.03760601
107Abnormal enzyme/coenzyme activity (HP:0012379)2.03200429
108Purpura (HP:0000979)2.01520332
109Hemorrhage of the eye (HP:0011885)2.00812046
110Abnormalities of placenta or umbilical cord (HP:0001194)2.00368932
111Gingival bleeding (HP:0000225)1.99404886
112Systemic lupus erythematosus (HP:0002725)1.97663509
113Sensorimotor neuropathy (HP:0007141)1.97087016
114Abnormal gallbladder morphology (HP:0012437)1.96915663
115Esophageal varix (HP:0002040)1.96724520
116Irritability (HP:0000737)1.96519549
117Diaphragmatic weakness (HP:0009113)1.96029027
118Abnormality of transition element cation homeostasis (HP:0011030)1.95062240
119Abnormal tarsal ossification (HP:0008369)1.95013009
120Abnormal cartilage morphology (HP:0002763)1.93414164
121Progressive external ophthalmoplegia (HP:0000590)1.92198604
122Distal lower limb amyotrophy (HP:0008944)1.91678755
123Brushfield spots (HP:0001088)1.91446030
124Bulbar palsy (HP:0001283)1.91047301
125Ileus (HP:0002595)1.90942239
126Protuberant abdomen (HP:0001538)1.90545790
127Neonatal onset (HP:0003623)1.89624878
128Cholelithiasis (HP:0001081)1.89357483
129Abnormality of alkaline phosphatase activity (HP:0004379)1.89019677
130Thrombophlebitis (HP:0004418)1.88554483
131Abnormality of subcutaneous fat tissue (HP:0001001)1.88066446
132Polygenic inheritance (HP:0010982)1.87831080
133Pancreatic islet-cell hyperplasia (HP:0004510)1.87645019
134Elevated alkaline phosphatase (HP:0003155)1.87123235
135Cortical visual impairment (HP:0100704)1.86797732
136Reduced antithrombin III activity (HP:0001976)1.86622631
137Decreased electroretinogram (ERG) amplitude (HP:0000654)1.85642625
138Gastrointestinal dysmotility (HP:0002579)1.84589571
139Petechiae (HP:0000967)1.84561027
140Polycythemia (HP:0001901)1.83633560
141Abnormality of carpal bone ossification (HP:0006257)1.83301394
142Nephrolithiasis (HP:0000787)1.83040592
143Impaired platelet aggregation (HP:0003540)1.82554415
144Abnormal platelet function (HP:0011869)1.82554415
145Increased connective tissue (HP:0009025)1.82062111
146Vomiting (HP:0002013)1.81572588
147Abnormality of iron homeostasis (HP:0011031)1.81540707
148Increased purine levels (HP:0004368)1.81385541
149Hyperuricemia (HP:0002149)1.81385541
150Global brain atrophy (HP:0002283)1.81340963
151Flat acetabular roof (HP:0003180)1.79979109
152Hypertriglyceridemia (HP:0002155)1.78103699
153Patchy hypopigmentation of hair (HP:0011365)1.77281733
154Hypokinesia (HP:0002375)1.76137474
155Pulmonary embolism (HP:0002204)1.74285864
156Aplasia/Hypoplasia of the sacrum (HP:0008517)1.72365510
157Conjunctival telangiectasia (HP:0000524)1.71518824
158Visceral angiomatosis (HP:0100761)1.71100969
159Hypoparathyroidism (HP:0000829)1.71017432
160Premature ovarian failure (HP:0008209)1.70658401
161Muscle stiffness (HP:0003552)1.70446212
162Reticulocytosis (HP:0001923)1.70203222
163Insomnia (HP:0100785)1.69546973
164Abnormality of reticulocytes (HP:0004312)1.68614719
165Increased cerebral lipofuscin (HP:0011813)1.67188648
166Heterochromia iridis (HP:0001100)1.66434637
167Reticulocytopenia (HP:0001896)1.65261212
168Muscle fiber inclusion bodies (HP:0100299)1.64820448
169Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.64256353
170Abnormality of glycosphingolipid metabolism (HP:0004343)1.63122279
171Abnormality of glycolipid metabolism (HP:0010969)1.63122279

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.74715136
2BCKDK5.03325914
3TRIB34.17351499
4PKN23.75492437
5TAOK33.17022967
6SMG13.14572657
7SIK13.02921499
8INSRR2.90012677
9FLT32.63170378
10FGFR42.45494984
11MAP3K102.29324844
12PIM22.14550593
13STK161.98178695
14PTK61.96083609
15RIPK11.91373174
16VRK21.89046460
17ICK1.88625925
18PIK3CG1.82235736
19IRAK31.74857989
20MAP2K31.69688555
21CDK91.69065855
22TESK11.61192986
23ARAF1.58549775
24MAP4K11.55318085
25PRPF4B1.50123129
26KDR1.43391496
27EPHB11.43082539
28ZAP701.38397192
29LRRK21.38251012
30TYK21.34277668
31EEF2K1.31188202
32TAOK21.29284661
33MAPK111.22721599
34GRK61.16304188
35FGR1.16189567
36SCYL21.12994600
37MAPK151.12144254
38MAP3K71.11510792
39BTK1.10316887
40TTN1.09401498
41TGFBR21.07704683
42CDK121.04779919
43MAP3K11.04099015
44MAP3K111.03144402
45TBK11.03048391
46PTK21.00798666
47BUB10.98954607
48AURKA0.96754522
49JAK20.95925708
50CDK70.95771772
51IRAK40.93512054
52MAP2K20.93141465
53PRKD30.92906443
54PASK0.91382277
55JAK10.91331441
56STK100.89670888
57MAPKAPK30.87841160
58HIPK20.86194566
59FRK0.84365176
60CSK0.82071232
61RPS6KA40.81806481
62NEK90.81448572
63NME20.81271405
64MST1R0.76199048
65PBK0.74859762
66CDK80.74471493
67CAMK1D0.74220517
68CCNB10.74008790
69JAK30.73974205
70MAP3K30.72937733
71PDGFRA0.72723733
72TAOK10.71665019
73LIMK10.71474297
74IRAK20.71166558
75MTOR0.68143919
76TESK20.67499373
77EIF2AK10.67212512
78LMTK20.67117969
79DYRK1B0.65492134
80PDPK10.65111024
81LATS10.63907233
82PDK20.63165532
83RAF10.62539736
84CAMK2G0.62130967
85PRKD10.61664947
86BLK0.61322990
87DAPK10.60811811
88PRKAA20.60160480
89MUSK0.59931474
90RET0.59448320
91KIT0.58545413
92AKT20.58402204
93MAP3K80.57942755
94ITK0.57657946
95KSR20.55615881
96PRKCH0.52259870
97EPHA30.51868744
98BRSK20.51434453
99ILK0.50878932
100WNK40.50825625
101CSF1R0.50574448
102PAK20.48229054
103MET0.47812447
104MAP2K60.46748436
105PIK3CA0.45967442
106NEK10.45415136
107BMX0.45019712
108MAP2K40.44834983
109BRAF0.44785954
110PAK10.44595126
111MYLK0.43316163
112CAMK1G0.42950429
113TEC0.42705450
114PAK40.42532665
115MAP3K20.41961889
116MAP2K10.40968544
117CDK60.40817799
118CDK40.40699620
119PRKD20.40626758
120PDK10.40212696
121RPS6KA10.39708740
122RPS6KB10.38594261
123MAPKAPK20.38225166
124MAP3K50.37506246
125MAPK40.37009123
126PRKG20.36877391
127RPS6KB20.34820322
128MAPK120.34787915
129ERBB40.34170137
130SIK30.33588393
131DAPK30.32589476
132ATR0.32308000
133MAP3K60.32198442
134RPS6KL10.31416568
135RPS6KC10.31416568
136BRSK10.31070509
137OBSCN0.30658122
138CAMK2D0.30550701
139MOS0.30271062
140PRKCI0.29619317
141MAP3K130.28450999
142EPHA20.28372075
143RPS6KA20.27687310
144IKBKE0.26868223
145SYK0.26336769
146PRKAA10.26012047
147MARK30.25674122
148NLK0.25632096
149ALK0.24297393
150GSK3A0.24154397
151ABL20.23699896

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.62464299
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33915848
3Nitrogen metabolism_Homo sapiens_hsa009103.08460554
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.81518495
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.78735286
6Fatty acid degradation_Homo sapiens_hsa000712.67171257
7Tryptophan metabolism_Homo sapiens_hsa003802.57271679
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.56432949
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.56269408
10Arginine biosynthesis_Homo sapiens_hsa002202.53376623
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.35105378
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.18431491
13Complement and coagulation cascades_Homo sapiens_hsa046102.18410413
14DNA replication_Homo sapiens_hsa030302.15949804
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.14660476
16Base excision repair_Homo sapiens_hsa034102.00845922
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.98570089
18Propanoate metabolism_Homo sapiens_hsa006401.97321622
19Selenocompound metabolism_Homo sapiens_hsa004501.96565622
20Peroxisome_Homo sapiens_hsa041461.88890199
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.86265723
22Butanoate metabolism_Homo sapiens_hsa006501.85418186
23Sulfur metabolism_Homo sapiens_hsa009201.83000078
24Folate biosynthesis_Homo sapiens_hsa007901.81236941
25Fat digestion and absorption_Homo sapiens_hsa049751.80199171
26Fatty acid metabolism_Homo sapiens_hsa012121.77622713
27PPAR signaling pathway_Homo sapiens_hsa033201.76908717
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.72562010
29Vibrio cholerae infection_Homo sapiens_hsa051101.66257904
30Histidine metabolism_Homo sapiens_hsa003401.64449944
31Caffeine metabolism_Homo sapiens_hsa002321.61248123
32beta-Alanine metabolism_Homo sapiens_hsa004101.58042461
33Proteasome_Homo sapiens_hsa030501.57183488
34Pyruvate metabolism_Homo sapiens_hsa006201.54563947
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.53318596
36Starch and sucrose metabolism_Homo sapiens_hsa005001.48240318
37Bile secretion_Homo sapiens_hsa049761.47323618
38Staphylococcus aureus infection_Homo sapiens_hsa051501.43346681
39Carbon metabolism_Homo sapiens_hsa012001.42823089
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.41440691
41Biosynthesis of amino acids_Homo sapiens_hsa012301.40274314
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.38956353
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.38904107
44Chemical carcinogenesis_Homo sapiens_hsa052041.37466436
45ABC transporters_Homo sapiens_hsa020101.31309362
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.30669089
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.21496086
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19673558
49Lysine degradation_Homo sapiens_hsa003101.15251270
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11923724
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.11870890
52Sulfur relay system_Homo sapiens_hsa041221.11817771
53Phenylalanine metabolism_Homo sapiens_hsa003601.10628243
54Spliceosome_Homo sapiens_hsa030401.09508296
55One carbon pool by folate_Homo sapiens_hsa006701.07123168
56Retinol metabolism_Homo sapiens_hsa008301.05193051
57Arginine and proline metabolism_Homo sapiens_hsa003301.02211112
58Pyrimidine metabolism_Homo sapiens_hsa002401.01655616
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.01248374
60Glycerolipid metabolism_Homo sapiens_hsa005610.95222880
61Vitamin digestion and absorption_Homo sapiens_hsa049770.93661491
62* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93363874
63Tyrosine metabolism_Homo sapiens_hsa003500.92018929
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91312291
65Collecting duct acid secretion_Homo sapiens_hsa049660.90748346
66Galactose metabolism_Homo sapiens_hsa000520.88338472
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86952185
68Protein export_Homo sapiens_hsa030600.84160800
69Ribosome_Homo sapiens_hsa030100.83084956
70Pentose phosphate pathway_Homo sapiens_hsa000300.82551961
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81952103
72Fatty acid elongation_Homo sapiens_hsa000620.81212496
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77630741
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.77290867
75Glutathione metabolism_Homo sapiens_hsa004800.74425782
76Thyroid cancer_Homo sapiens_hsa052160.73103409
77Insulin resistance_Homo sapiens_hsa049310.72991617
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67955743
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66538666
80Other glycan degradation_Homo sapiens_hsa005110.64712372
81Mismatch repair_Homo sapiens_hsa034300.63903831
82Fructose and mannose metabolism_Homo sapiens_hsa000510.62189328
83mRNA surveillance pathway_Homo sapiens_hsa030150.56179939
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53445146
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.52673559
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51587183
87Non-small cell lung cancer_Homo sapiens_hsa052230.51526917
88Nucleotide excision repair_Homo sapiens_hsa034200.50600647
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49716639
90Chronic myeloid leukemia_Homo sapiens_hsa052200.49208631
91Vitamin B6 metabolism_Homo sapiens_hsa007500.48432256
92RNA transport_Homo sapiens_hsa030130.48387876
93Metabolic pathways_Homo sapiens_hsa011000.42617453
94Steroid biosynthesis_Homo sapiens_hsa001000.42085593
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.39292437
96Glucagon signaling pathway_Homo sapiens_hsa049220.38612578
97Synaptic vesicle cycle_Homo sapiens_hsa047210.38203432
98Apoptosis_Homo sapiens_hsa042100.36962440
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34777596
100Lysosome_Homo sapiens_hsa041420.34251329
101Protein digestion and absorption_Homo sapiens_hsa049740.34063192
102Epstein-Barr virus infection_Homo sapiens_hsa051690.33797157
103N-Glycan biosynthesis_Homo sapiens_hsa005100.33787000
104Oxidative phosphorylation_Homo sapiens_hsa001900.31606748
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31354468
106Purine metabolism_Homo sapiens_hsa002300.30015953
107Pertussis_Homo sapiens_hsa051330.29665050
108Shigellosis_Homo sapiens_hsa051310.28311522
109Viral carcinogenesis_Homo sapiens_hsa052030.28150046
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26393920
111Prion diseases_Homo sapiens_hsa050200.25093430
112Fatty acid biosynthesis_Homo sapiens_hsa000610.23777394
113Bladder cancer_Homo sapiens_hsa052190.23180336
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22572879
115Insulin signaling pathway_Homo sapiens_hsa049100.22402132
116B cell receptor signaling pathway_Homo sapiens_hsa046620.21701479
117AMPK signaling pathway_Homo sapiens_hsa041520.21445647
118Parkinsons disease_Homo sapiens_hsa050120.20954214
119HTLV-I infection_Homo sapiens_hsa051660.20669946
120Pancreatic secretion_Homo sapiens_hsa049720.20064337
121Renin-angiotensin system_Homo sapiens_hsa046140.18562289
122Legionellosis_Homo sapiens_hsa051340.18541767
123Herpes simplex infection_Homo sapiens_hsa051680.18471829
124Thyroid hormone synthesis_Homo sapiens_hsa049180.14243635
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.12517531
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.09590113
127Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.06810782
128Type II diabetes mellitus_Homo sapiens_hsa049300.06707944
129Acute myeloid leukemia_Homo sapiens_hsa052210.05223416
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.04051242
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.02755034
132Linoleic acid metabolism_Homo sapiens_hsa00591-0.0538190
133Hepatitis C_Homo sapiens_hsa05160-0.0322477
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0183792

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