PRELID1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the late embryogenesis abundant motif-containing protein family. The encoded protein is localized to mitochondria and may function as a cytoprotectant by regulating cell death and differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. Several related pseudogenes have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.86135617
2viral transcription (GO:0019083)4.56563851
3formation of translation preinitiation complex (GO:0001731)4.51797167
4translational termination (GO:0006415)4.45479840
5GDP-mannose metabolic process (GO:0019673)4.28812777
6protein maturation by protein folding (GO:0022417)4.18532747
7translational elongation (GO:0006414)4.13643465
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.90553773
9DNA strand elongation involved in DNA replication (GO:0006271)3.90334792
10maturation of SSU-rRNA (GO:0030490)3.86782023
11translational initiation (GO:0006413)3.86310295
12proline biosynthetic process (GO:0006561)3.85669675
13folic acid-containing compound biosynthetic process (GO:0009396)3.80725452
14protein targeting to ER (GO:0045047)3.77879211
15cotranslational protein targeting to membrane (GO:0006613)3.76054502
16DNA deamination (GO:0045006)3.75549573
17DNA strand elongation (GO:0022616)3.68194900
18DNA unwinding involved in DNA replication (GO:0006268)3.67780128
19peptidyl-arginine omega-N-methylation (GO:0035247)3.62540065
20viral life cycle (GO:0019058)3.59563626
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.59520916
22establishment of protein localization to endoplasmic reticulum (GO:0072599)3.55142188
23protein localization to endoplasmic reticulum (GO:0070972)3.55131448
24negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.53641972
25ribosomal small subunit biogenesis (GO:0042274)3.53379469
26cellular protein complex disassembly (GO:0043624)3.49051343
27telomere maintenance via semi-conservative replication (GO:0032201)3.48902645
28establishment of integrated proviral latency (GO:0075713)3.47565420
29regulation of mitochondrial translation (GO:0070129)3.45327525
30regulation of protein heterodimerization activity (GO:0043497)3.41053587
31nucleobase biosynthetic process (GO:0046112)3.38281535
32establishment of viral latency (GO:0019043)3.35749086
33DNA replication initiation (GO:0006270)3.28552199
34protein localization to kinetochore (GO:0034501)3.25678737
35ribosomal large subunit biogenesis (GO:0042273)3.24025213
36pentose-phosphate shunt (GO:0006098)3.22250817
37Arp2/3 complex-mediated actin nucleation (GO:0034314)3.21401997
38purine nucleobase biosynthetic process (GO:0009113)3.16057230
39protein complex disassembly (GO:0043241)3.15356663
40histone arginine methylation (GO:0034969)3.12091750
41regulation of mammary gland epithelial cell proliferation (GO:0033599)3.07857275
42folic acid metabolic process (GO:0046655)3.04989836
43mitotic nuclear envelope reassembly (GO:0007084)3.04023694
44nuclear envelope reassembly (GO:0031468)3.04023694
45guanosine-containing compound biosynthetic process (GO:1901070)3.02158970
46pentose metabolic process (GO:0019321)3.01990663
47nucleoside salvage (GO:0043174)3.01970205
48negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.00391423
49translation (GO:0006412)2.98678518
50telomere maintenance via recombination (GO:0000722)2.97687290
51macromolecular complex disassembly (GO:0032984)2.96088432
52mitotic nuclear envelope disassembly (GO:0007077)2.95842119
53T cell apoptotic process (GO:0070231)2.92975165
54ribonucleoprotein complex biogenesis (GO:0022613)2.92776356
552-deoxyribonucleotide biosynthetic process (GO:0009265)2.90504743
56deoxyribose phosphate biosynthetic process (GO:0046385)2.90504743
57viral mRNA export from host cell nucleus (GO:0046784)2.89399006
58NADPH regeneration (GO:0006740)2.89235957
59nucleobase-containing small molecule interconversion (GO:0015949)2.85709996
60IMP biosynthetic process (GO:0006188)2.84078866
61anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.82008627
62positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.81590452
63peptidyl-arginine methylation (GO:0018216)2.80379383
64peptidyl-arginine N-methylation (GO:0035246)2.80379383
65regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.80346596
66antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.78553329
67DNA replication checkpoint (GO:0000076)2.78403949
68protein targeting to mitochondrion (GO:0006626)2.77600818
69pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.76012770
70protein localization to chromosome, centromeric region (GO:0071459)2.75410394
71negative regulation of ligase activity (GO:0051352)2.74181386
72negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.74181386
73negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.73718900
74heterochromatin organization (GO:0070828)2.73532629
75antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.73186168
76deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.72853334
77regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.72697669
78membrane disassembly (GO:0030397)2.71934388
79nuclear envelope disassembly (GO:0051081)2.71934388
80NIK/NF-kappaB signaling (GO:0038061)2.71425084
81mitotic recombination (GO:0006312)2.71211980
82pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.70607820
83pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.69973658
84rRNA transcription (GO:0009303)2.69716832
85ribosome biogenesis (GO:0042254)2.69420363
86ribosome assembly (GO:0042255)2.69394837
87protein retention in ER lumen (GO:0006621)2.68934680
88pteridine-containing compound biosynthetic process (GO:0042559)2.68571889
89pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.66427102
90proteasome assembly (GO:0043248)2.66198522
91pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.65310997
92nuclear-transcribed mRNA catabolic process (GO:0000956)2.65044796
93positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.63697539
94cellular component biogenesis (GO:0044085)2.63430552
95mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.61633142
96tetrahydrofolate metabolic process (GO:0046653)2.61504948
97telomere maintenance via telomere lengthening (GO:0010833)2.60895764
98deoxyribonucleotide biosynthetic process (GO:0009263)2.60148488
99DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.59424495
100maternal placenta development (GO:0001893)2.59214407
101UTP biosynthetic process (GO:0006228)2.58913822
102spliceosomal tri-snRNP complex assembly (GO:0000244)2.58318546
103maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.57975180
104pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.57360189
105establishment of protein localization to mitochondrion (GO:0072655)2.56801252
106pseudouridine synthesis (GO:0001522)2.55685231
107NADH metabolic process (GO:0006734)2.54321854
108signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.54176906
109intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.54176906
110glucose catabolic process (GO:0006007)2.53478018
111protein targeting to membrane (GO:0006612)2.53470333
112COPI coating of Golgi vesicle (GO:0048205)2.52018031
113Golgi transport vesicle coating (GO:0048200)2.52018031
114oxidative phosphorylation (GO:0006119)2.51489404
115spliceosomal snRNP assembly (GO:0000387)2.51409156
116mitochondrial fusion (GO:0008053)2.50812493
117chaperone-mediated protein transport (GO:0072321)2.50024893
118mRNA catabolic process (GO:0006402)2.49808147
119regulation of superoxide anion generation (GO:0032928)2.49489942
120signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.49451330
121signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.49451330
122signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.49451330
123retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.49065568
124lymphocyte apoptotic process (GO:0070227)2.49005078
125regulation of cellular amino acid metabolic process (GO:0006521)2.48930510
126RNA catabolic process (GO:0006401)2.47497120
127positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.46640084
128IMP metabolic process (GO:0046040)2.46373401
129signal transduction involved in DNA damage checkpoint (GO:0072422)2.45648602
130signal transduction involved in DNA integrity checkpoint (GO:0072401)2.45648602
131pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.45467030
132mitotic metaphase plate congression (GO:0007080)2.44103062
133nucleotide-excision repair, DNA gap filling (GO:0006297)2.44029539
134rRNA processing (GO:0006364)2.43868525
135cell cycle G1/S phase transition (GO:0044843)2.42796959
136G1/S transition of mitotic cell cycle (GO:0000082)2.42796959
137regulation of translational fidelity (GO:0006450)2.42744247
138galactose catabolic process (GO:0019388)2.42289049
139regulation of translational termination (GO:0006449)2.41779904
140signal transduction involved in cell cycle checkpoint (GO:0072395)2.39679515
141DNA replication-dependent nucleosome assembly (GO:0006335)2.39173644
142DNA replication-dependent nucleosome organization (GO:0034723)2.39173644
143positive regulation of ligase activity (GO:0051351)2.35389320
144glycine metabolic process (GO:0006544)2.34856239
145folic acid-containing compound metabolic process (GO:0006760)2.34467317
146activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.33990191

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.50519334
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.12201494
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.58704747
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.85816366
5MYC_18358816_ChIP-ChIP_MESCs_Mouse2.46808213
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.46029265
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.34812013
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.27088123
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.25060560
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.21842546
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.20726718
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.20119284
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.18926788
14* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.17926039
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.16479954
16XRN2_22483619_ChIP-Seq_HELA_Human2.13492403
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.12824557
18MYC_22102868_ChIP-Seq_BL_Human2.06848944
19NELFA_20434984_ChIP-Seq_ESCs_Mouse1.97411623
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.90294017
21E2F1_18555785_ChIP-Seq_MESCs_Mouse1.82526735
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.82156918
23ZNF263_19887448_ChIP-Seq_K562_Human1.80869038
24ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79210636
25DCP1A_22483619_ChIP-Seq_HELA_Human1.74330016
26VDR_21846776_ChIP-Seq_THP-1_Human1.73203165
27* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.69065072
28AR_21909140_ChIP-Seq_LNCAP_Human1.66123474
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.65714463
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.64832446
31TP63_17297297_ChIP-ChIP_HaCaT_Human1.64145199
32LXR_22292898_ChIP-Seq_THP-1_Human1.64118863
33VDR_23849224_ChIP-Seq_CD4+_Human1.63211967
34GABP_19822575_ChIP-Seq_HepG2_Human1.61554506
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.59014963
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50721860
37STAT3_1855785_ChIP-Seq_MESCs_Mouse1.50577596
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.48717642
39ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48659690
40ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.48348722
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47704624
42FOXP3_21729870_ChIP-Seq_TREG_Human1.47207901
43TTF2_22483619_ChIP-Seq_HELA_Human1.44392738
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43701727
45* TET1_21451524_ChIP-Seq_MESCs_Mouse1.43178783
46RACK7_27058665_Chip-Seq_MCF-7_Human1.42081336
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.40874026
48NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.39958677
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39408506
50BP1_19119308_ChIP-ChIP_Hs578T_Human1.35751240
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34643785
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.34111903
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33893265
54CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33056278
55KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30674384
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30360175
57* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29784071
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.29775506
59TFEB_21752829_ChIP-Seq_HELA_Human1.28694201
60CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28618206
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.28149572
62CIITA_25753668_ChIP-Seq_RAJI_Human1.27962085
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25488865
64RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24342061
65THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23908921
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.23181216
67KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22860768
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22671495
69* SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.22451728
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21224022
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19782128
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19195536
73SPI1_23547873_ChIP-Seq_NB4_Human1.18761146
74IRF8_22096565_ChIP-ChIP_GC-B_Human1.17499444
75YY1_21170310_ChIP-Seq_MESCs_Mouse1.17170998
76MYB_21317192_ChIP-Seq_ERMYB_Mouse1.15827045
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15331435
78P68_20966046_ChIP-Seq_HELA_Human1.15322857
79KDM5A_27292631_Chip-Seq_BREAST_Human1.15202096
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14437421
81ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14035918
82HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13555029
83CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13271460
84MAF_26560356_Chip-Seq_TH2_Human1.13234819
85MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.11838548
86CTCF_18555785_ChIP-Seq_MESCs_Mouse1.11696720
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11132423
88SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10533287
89CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09736559
90CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09573453
91SRF_21415370_ChIP-Seq_HL-1_Mouse1.09194517
92ATF3_27146783_Chip-Seq_COLON_Human1.08917989
93ELK1_19687146_ChIP-ChIP_HELA_Human1.08654740
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08095634
95MAF_26560356_Chip-Seq_TH1_Human1.07695549
96* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07691919
97HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07151263
98SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06844996
99MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06298262
100* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05909568
101ELF1_20517297_ChIP-Seq_JURKAT_Human1.05768521
102HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05156932
103RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04747903
104STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04390790
105SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03287576
106PPARA_22158963_ChIP-Seq_LIVER_Mouse1.02976184
107OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02898224
108PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02671861
109SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02045591
110TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00354719
111ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00252395
112BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99787136
113SA1_27219007_Chip-Seq_ERYTHROID_Human0.99698281
114IRF8_21731497_ChIP-ChIP_J774_Mouse0.99296302
115CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99060671
116UTX_26944678_Chip-Seq_JUKART_Human0.98652030
117HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96450551
118TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95587663
119TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94811534
120E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94007412
121VDR_24763502_ChIP-Seq_THP-1_Human0.93785169
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93780500
123IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.93353395
124NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92975184
125GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92299793

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.70654924
2MP0005451_abnormal_body_composition3.16680112
3MP0004957_abnormal_blastocyst_morpholog2.88588326
4MP0002877_abnormal_melanocyte_morpholog2.81830170
5MP0003705_abnormal_hypodermis_morpholog2.77741921
6MP0010352_gastrointestinal_tract_polyps2.69759725
7MP0003111_abnormal_nucleus_morphology2.43104395
8MP0003806_abnormal_nucleotide_metabolis2.41924120
9MP0003077_abnormal_cell_cycle2.32976472
10MP0008260_abnormal_autophagy2.25637126
11MP0009840_abnormal_foam_cell2.06192114
12MP0003436_decreased_susceptibility_to1.97878147
13MP0010094_abnormal_chromosome_stability1.95327978
14MP0009333_abnormal_splenocyte_physiolog1.95270508
15MP0000490_abnormal_crypts_of1.94714449
16MP0006054_spinal_hemorrhage1.92155863
17MP0005501_abnormal_skin_physiology1.89890822
18MP0004185_abnormal_adipocyte_glucose1.80983368
19MP0002796_impaired_skin_barrier1.77432436
20MP0005360_urolithiasis1.76750808
21MP0003186_abnormal_redox_activity1.72413686
22MP0008007_abnormal_cellular_replicative1.71300851
23MP0008438_abnormal_cutaneous_collagen1.71052243
24MP0004858_abnormal_nervous_system1.69013354
25MP0002396_abnormal_hematopoietic_system1.67458553
26MP0001730_embryonic_growth_arrest1.63881118
27MP0005023_abnormal_wound_healing1.63085069
28MP0000678_abnormal_parathyroid_gland1.61815352
29MP0000858_altered_metastatic_potential1.61443300
30MP0008932_abnormal_embryonic_tissue1.56314246
31MP0010307_abnormal_tumor_latency1.53543539
32MP0003566_abnormal_cell_adhesion1.48904219
33MP0005397_hematopoietic_system_phenotyp1.43691972
34MP0001545_abnormal_hematopoietic_system1.43691972
35MP0001835_abnormal_antigen_presentation1.43527540
36MP0009379_abnormal_foot_pigmentation1.42396027
37MP0003786_premature_aging1.39648168
38MP0009785_altered_susceptibility_to1.37827009
39MP0004233_abnormal_muscle_weight1.37477270
40MP0000685_abnormal_immune_system1.37346069
41MP0000350_abnormal_cell_proliferation1.36245798
42MP0010030_abnormal_orbit_morphology1.35651177
43MP0004808_abnormal_hematopoietic_stem1.32114575
44MP0003123_paternal_imprinting1.31329233
45MP0003453_abnormal_keratinocyte_physiol1.28251536
46MP0006035_abnormal_mitochondrial_morpho1.25024930
47MP0002019_abnormal_tumor_incidence1.24727988
48MP0010155_abnormal_intestine_physiology1.20773174
49MP0002722_abnormal_immune_system1.18709107
50MP0005025_abnormal_response_to1.18155313
51MP0005076_abnormal_cell_differentiation1.17711883
52MP0001853_heart_inflammation1.17505459
53MP0006036_abnormal_mitochondrial_physio1.17368216
54MP0001849_ear_inflammation1.16907309
55MP0002405_respiratory_system_inflammati1.16286149
56MP0002398_abnormal_bone_marrow1.15925931
57MP0001697_abnormal_embryo_size1.15695221
58MP0003303_peritoneal_inflammation1.15002169
59MP0002080_prenatal_lethality1.12976388
60MP0000689_abnormal_spleen_morphology1.11923987
61MP0009053_abnormal_anal_canal1.11289293
62MP0001881_abnormal_mammary_gland1.09428732
63MP0004782_abnormal_surfactant_physiolog1.09089340
64MP0003763_abnormal_thymus_physiology1.08746529
65MP0002452_abnormal_antigen_presenting1.07644632
66MP0001727_abnormal_embryo_implantation1.05626072
67MP0000313_abnormal_cell_death1.05177514
68MP0003315_abnormal_perineum_morphology1.04906677
69MP0005464_abnormal_platelet_physiology1.04369535
70MP0002429_abnormal_blood_cell1.04170876
71MP0002086_abnormal_extraembryonic_tissu1.03621819
72MP0005000_abnormal_immune_tolerance1.02727796
73MP0008058_abnormal_DNA_repair1.02677631
74MP0001800_abnormal_humoral_immune1.02098119
75MP0001672_abnormal_embryogenesis/_devel1.01372843
76MP0005380_embryogenesis_phenotype1.01372843
77MP0003984_embryonic_growth_retardation1.00869104
78MP0002148_abnormal_hypersensitivity_rea1.00743321
79MP0001216_abnormal_epidermal_layer0.99128480
80MP0002088_abnormal_embryonic_growth/wei0.99078395
81MP0001845_abnormal_inflammatory_respons0.98796627
82MP0000477_abnormal_intestine_morphology0.98582693
83MP0002139_abnormal_hepatobiliary_system0.98537764
84MP0010234_abnormal_vibrissa_follicle0.98340595
85MP0009278_abnormal_bone_marrow0.98095973
86MP0000598_abnormal_liver_morphology0.97951139
87MP0001819_abnormal_immune_cell0.97327663
88MP0002420_abnormal_adaptive_immunity0.96630099
89MP0003300_gastrointestinal_ulcer0.95687338
90MP0008057_abnormal_DNA_replication0.95592828
91MP0005623_abnormal_meninges_morphology0.95446729
92MP0004264_abnormal_extraembryonic_tissu0.95162435
93MP0002163_abnormal_gland_morphology0.94586794
94MP0001533_abnormal_skeleton_physiology0.94506661
95MP0000716_abnormal_immune_system0.94107206
96MP0002419_abnormal_innate_immunity0.93927071
97MP0000537_abnormal_urethra_morphology0.93528233
98MP0003866_abnormal_defecation0.93311679
99MP0004197_abnormal_fetal_growth/weight/0.93203130
100MP0004947_skin_inflammation0.93063752
101MP0003448_altered_tumor_morphology0.92984506
102MP0000358_abnormal_cell_content/0.91636658
103MP0001661_extended_life_span0.90968809
104MP0002723_abnormal_immune_serum0.90882157
105MP0003567_abnormal_fetal_cardiomyocyte0.90807550
106MP0003075_altered_response_to0.90755625
107MP0003279_aneurysm0.90247782
108MP0000703_abnormal_thymus_morphology0.90016250
109MP0003191_abnormal_cellular_cholesterol0.86475101
110MP0005275_abnormal_skin_tensile0.86169061
111MP0008469_abnormal_protein_level0.85874644
112MP0003221_abnormal_cardiomyocyte_apopto0.85523222
113MP0005666_abnormal_adipose_tissue0.85117077
114MP0005058_abnormal_lysosome_morphology0.84553997
115MP0009643_abnormal_urine_homeostasis0.83987540
116MP0005319_abnormal_enzyme/_coenzyme0.83131225
117MP0005083_abnormal_biliary_tract0.82750977
118MP0006082_CNS_inflammation0.82677678
119MP0000465_gastrointestinal_hemorrhage0.81562986
120MP0001346_abnormal_lacrimal_gland0.81133975
121MP0000343_altered_response_to0.80857738
122MP0001666_abnormal_nutrient_absorption0.80347709
123MP0001790_abnormal_immune_system0.80320481
124MP0005671_abnormal_response_to0.80260162
125MP0002132_abnormal_respiratory_system0.80057228
126MP0001915_intracranial_hemorrhage0.79924753
127MP0002085_abnormal_embryonic_tissue0.78388044
128MP0003656_abnormal_erythrocyte_physiolo0.78386581
129MP0002089_abnormal_postnatal_growth/wei0.77456827
130MP0001873_stomach_inflammation0.76289579

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)3.84639293
2Reticulocytopenia (HP:0001896)3.78469380
3Abnormal number of erythroid precursors (HP:0012131)3.57346632
4Ragged-red muscle fibers (HP:0003200)3.42389043
5Protrusio acetabuli (HP:0003179)3.28454121
6Multiple enchondromatosis (HP:0005701)3.21753706
7Microvesicular hepatic steatosis (HP:0001414)3.21454600
8Progressive muscle weakness (HP:0003323)3.08803688
9Thrombocytosis (HP:0001894)2.99120827
10Trismus (HP:0000211)2.95420047
11Abnormality of the anterior horn cell (HP:0006802)2.82550047
12Degeneration of anterior horn cells (HP:0002398)2.82550047
13Elevated erythrocyte sedimentation rate (HP:0003565)2.78682113
14Oral leukoplakia (HP:0002745)2.72485242
15Macrocytic anemia (HP:0001972)2.69853084
16Microretrognathia (HP:0000308)2.66710067
17Increased intramyocellular lipid droplets (HP:0012240)2.64174987
18Hypertensive crisis (HP:0100735)2.62089082
19Selective tooth agenesis (HP:0001592)2.58682148
20Increased muscle lipid content (HP:0009058)2.57843073
21Abnormality of the umbilical cord (HP:0010881)2.56489753
22Pallor (HP:0000980)2.52318169
23Petechiae (HP:0000967)2.49739028
24Testicular atrophy (HP:0000029)2.48883816
25Vertebral compression fractures (HP:0002953)2.48095913
26Achilles tendon contracture (HP:0001771)2.40688378
27Obstructive lung disease (HP:0006536)2.37370346
28Chronic obstructive pulmonary disease (HP:0006510)2.37370346
29Eczematoid dermatitis (HP:0000976)2.37019242
30Abnormality of pyrimidine metabolism (HP:0004353)2.35400966
31Spastic diplegia (HP:0001264)2.35174091
32Cervical subluxation (HP:0003308)2.34838751
33Abnormal umbilical cord blood vessels (HP:0011403)2.31653038
34Single umbilical artery (HP:0001195)2.31653038
35Abnormality of the fetal cardiovascular system (HP:0010948)2.31653038
36Abnormal mitochondria in muscle tissue (HP:0008316)2.28743561
37Abnormality of the distal phalanges of the toes (HP:0010182)2.26544358
38Poor head control (HP:0002421)2.25821902
39Abnormal gallbladder physiology (HP:0012438)2.25409763
40Cholecystitis (HP:0001082)2.25409763
41Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.24348381
42Abnormality of reticulocytes (HP:0004312)2.24294193
43Rough bone trabeculation (HP:0100670)2.23238702
44Aplastic anemia (HP:0001915)2.22702965
45Abnormality of glycolysis (HP:0004366)2.22382065
46Hepatosplenomegaly (HP:0001433)2.20938871
47Broad distal phalanx of finger (HP:0009836)2.17871175
48Hypokinesia (HP:0002375)2.13864672
49Hepatocellular necrosis (HP:0001404)2.13139162
50Birth length less than 3rd percentile (HP:0003561)2.12664033
51Abnormality of the Achilles tendon (HP:0005109)2.11888969
52Peritonitis (HP:0002586)2.11654164
53Increased serum pyruvate (HP:0003542)2.10628513
54Breast hypoplasia (HP:0003187)2.09916212
55Type I transferrin isoform profile (HP:0003642)2.07028981
56Pustule (HP:0200039)2.04511723
57Nausea (HP:0002018)2.02979237
58Increased serum ferritin (HP:0003281)2.02685014
59Fasciculations (HP:0002380)2.01571483
60Nonimmune hydrops fetalis (HP:0001790)2.01459879
61Carpal bone hypoplasia (HP:0001498)2.01376914
62Mitochondrial inheritance (HP:0001427)1.99018888
63Abnormalities of placenta or umbilical cord (HP:0001194)1.97802601
64Vacuolated lymphocytes (HP:0001922)1.97515639
65Abnormality of monocarboxylic acid metabolism (HP:0010996)1.96567872
66Increased serum lactate (HP:0002151)1.96312957
67Colon cancer (HP:0003003)1.96122410
68Seborrheic dermatitis (HP:0001051)1.95215237
69Biconcave vertebral bodies (HP:0004586)1.94748995
70Premature ovarian failure (HP:0008209)1.94590755
71Abnormal cartilage morphology (HP:0002763)1.93080556
72Lactic acidosis (HP:0003128)1.91077309
73Hyperacusis (HP:0010780)1.90724003
74Pancytopenia (HP:0001876)1.89767903
75Adenoma sebaceum (HP:0009720)1.89627750
76Angiofibromas (HP:0010615)1.89627750
77Hepatic necrosis (HP:0002605)1.87995679
78IgM deficiency (HP:0002850)1.87727258
79Hand muscle atrophy (HP:0009130)1.86221875
80Increased IgM level (HP:0003496)1.85389281
81Acute necrotizing encephalopathy (HP:0006965)1.83996526
82Increased CSF lactate (HP:0002490)1.83124678
83Interstitial pulmonary disease (HP:0006530)1.83035314
84Autoimmune thrombocytopenia (HP:0001973)1.82966741
85Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.82324755
86Recurrent abscess formation (HP:0002722)1.81870365
87Abnormality of liposaccharide metabolism (HP:0010968)1.81719993
88Abnormality of glycosphingolipid metabolism (HP:0004343)1.81719993
89Abnormality of glycolipid metabolism (HP:0010969)1.81719993
90Acute encephalopathy (HP:0006846)1.80528349
91Squamous cell carcinoma (HP:0002860)1.80058038
92Hyperparathyroidism (HP:0000843)1.79907422
93Neoplasm of the pancreas (HP:0002894)1.79511199
94Recurrent gram-negative bacterial infections (HP:0005420)1.78940141
95Reduced subcutaneous adipose tissue (HP:0003758)1.78239776
96Exercise intolerance (HP:0003546)1.77538426
97Death in infancy (HP:0001522)1.77522312
98Orthostatic hypotension (HP:0001278)1.77511821
99Myositis (HP:0100614)1.77166096
100Progressive neurologic deterioration (HP:0002344)1.77092506
101Aplasia/Hypoplasia of the sacrum (HP:0008517)1.75185007
102Secondary amenorrhea (HP:0000869)1.74699516
103Abnormality of macrophages (HP:0004311)1.74528957
104Beaking of vertebral bodies (HP:0004568)1.74210158
105Agnosia (HP:0010524)1.73899446
106Mediastinal lymphadenopathy (HP:0100721)1.72673837
107Increased hepatocellular lipid droplets (HP:0006565)1.72317547
108Abnormal platelet function (HP:0011869)1.71150380
109Impaired platelet aggregation (HP:0003540)1.71150380
110Abnormality of iron homeostasis (HP:0011031)1.70914993
111Ankle contracture (HP:0006466)1.70756730
112Premature rupture of membranes (HP:0001788)1.70658269
113Increased density of long bones (HP:0006392)1.69141675
114Lipid accumulation in hepatocytes (HP:0006561)1.69034312
115Slender long bone (HP:0003100)1.68603535
116Sparse eyelashes (HP:0000653)1.67148538
117Urticaria (HP:0001025)1.67033549
118Respiratory difficulties (HP:0002880)1.66374384
119Prolonged neonatal jaundice (HP:0006579)1.66291274
120Septate vagina (HP:0001153)1.66086041
121Abnormality of transition element cation homeostasis (HP:0011030)1.65887864
122Neoplasm of head and neck (HP:0012288)1.65605502
123Esophageal neoplasm (HP:0100751)1.65605502
124Basal cell carcinoma (HP:0002671)1.65430480
125Abnormality of T cell physiology (HP:0011840)1.64845952
126Hypobetalipoproteinemia (HP:0003563)1.64702019
127Entropion (HP:0000621)1.64675219
128Hypergonadotropic hypogonadism (HP:0000815)1.64395970
129Polygenic inheritance (HP:0010982)1.64118967
130Abnormality of the acetabulum (HP:0003170)1.63923475
131Renal Fanconi syndrome (HP:0001994)1.63197353
132Acute hepatic failure (HP:0006554)1.62896930
133Cerebral edema (HP:0002181)1.62038986
134Abnormality of the tricuspid valve (HP:0001702)1.61867166
135Hyperammonemia (HP:0001987)1.60987424
136Cellulitis (HP:0100658)1.60824135
137Abnormality of aromatic amino acid family metabolism (HP:0004338)1.59879612
138Decreased activity of mitochondrial respiratory chain (HP:0008972)1.59413411
139Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.59413411
140Atrophy/Degeneration involving motor neurons (HP:0007373)1.58987183
141Spastic paraparesis (HP:0002313)1.58942999
142Gastrointestinal dysmotility (HP:0002579)1.58840533
143Recurrent bacterial skin infections (HP:0005406)1.58318041
144Personality changes (HP:0000751)1.56831537
145Megaloblastic anemia (HP:0001889)1.56342076
146Genu recurvatum (HP:0002816)1.56012063
147Glossoptosis (HP:0000162)1.55713544
148Abnormal trabecular bone morphology (HP:0100671)1.55149360
149Reduced antithrombin III activity (HP:0001976)1.55068436
150Micronodular cirrhosis (HP:0001413)1.54404666
151Abnormality of the calcaneus (HP:0008364)1.53480740
152Ileus (HP:0002595)1.53427431
153Patellar aplasia (HP:0006443)1.53068797
154Abnormality of glutamine family amino acid metabolism (HP:0010902)1.52632395
155Deviation of the thumb (HP:0009603)1.52239111
156Mesangial abnormality (HP:0001966)1.51784283
157Aplasia/Hypoplasia of the patella (HP:0006498)1.48608040
158Chondrocalcinosis (HP:0000934)1.48542007
159Abnormality of T cells (HP:0002843)1.47580515
160Malnutrition (HP:0004395)1.47343346
161Cutaneous melanoma (HP:0012056)1.47233765
162Abnormal neuron morphology (HP:0012757)1.46960490
163Abnormality of the motor neurons (HP:0002450)1.46960490
164Tongue fasciculations (HP:0001308)1.44558521
165Premature graying of hair (HP:0002216)1.44476592
16611 pairs of ribs (HP:0000878)1.44235268
167Esophageal varix (HP:0002040)1.44135586
168Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.44100615
169Skin ulcer (HP:0200042)1.42569449
170Abnormality of the peritoneum (HP:0002585)1.42419543
171Osteolytic defects of the hand bones (HP:0009699)1.42247530
172Osteolytic defects of the phalanges of the hand (HP:0009771)1.42247530

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.41313557
2IRAK33.38350523
3VRK23.30543483
4BUB13.26818629
5SMG13.14944868
6PKN22.86725337
7TESK22.79480510
8TRIB32.68177121
9ERN12.59545157
10WEE12.36825413
11SCYL22.21906249
12TESK12.18492023
13PIM22.17409699
14RPS6KA42.15825641
15KDR2.12762832
16EIF2AK12.11258959
17NEK21.89466776
18LRRK21.85508858
19CDC71.84737711
20MAP3K101.83540875
21MAP3K111.82890131
22EEF2K1.80587348
23MAP4K11.79546101
24NEK11.78568155
25PRPF4B1.78140856
26PAK41.72461502
27STK101.59506712
28MAP2K31.54210811
29BCKDK1.53540729
30BLK1.52594645
31MAP3K81.47217804
32EPHA21.44863700
33RPS6KB21.42464435
34FLT31.40613416
35ZAP701.27380159
36ICK1.25720424
37BRSK21.21572739
38TGFBR11.19560173
39TBK11.18907629
40CDK71.15725936
41PASK1.14422637
42TYK21.13830537
43IRAK41.13458911
44MAP3K31.08809582
45AURKB1.06991782
46SIK11.06691947
47EIF2AK31.04919762
48MAPKAPK31.04042841
49TAOK21.03977928
50CDK41.00227276
51PLK10.98841991
52PTK60.98024468
53LIMK10.97530724
54GRK60.96553940
55STK160.96076344
56ILK0.94642241
57AURKA0.93453966
58TTK0.92814220
59TLK10.91703987
60DAPK10.89828264
61PIM10.89789411
62BTK0.87349399
63DYRK30.86486365
64ACVR1B0.85632701
65ARAF0.84954973
66PAK10.84840436
67CDK80.84237250
68JAK30.82035469
69BRSK10.75231382
70IRAK20.74948330
71ATR0.72316547
72BMX0.71062524
73NEK90.70357051
74CDK60.69861825
75CDK190.69482520
76MAP3K120.69104126
77ABL20.66150269
78PLK40.64433882
79NME10.63974779
80MAP3K10.63496315
81MAP2K20.61927213
82MST1R0.59342928
83TSSK60.58590788
84STK40.57163610
85MST40.57096736
86TAOK10.56347128
87VRK10.56340945
88BRAF0.54888241
89LMTK20.53599309
90FGFR40.51605458
91SRPK10.51409402
92PTK20.50194974
93MAP3K140.50154294
94RIPK40.50047370
95LATS20.48732289
96MAPKAPK20.46450189
97CSNK1G30.46128548
98PDPK10.46024091
99CDK120.45444964
100TTN0.44458164
101RIPK10.44001672
102KIT0.44001549
103IKBKB0.43684141
104RPS6KA50.43299478
105PBK0.42929480
106PRKCI0.41122582
107PRKG20.40933055
108MAPK110.40911028
109MOS0.40404597
110PAK20.40323914
111DAPK30.40157647
112CHUK0.38918410
113TAF10.38525815
114MARK30.38216422
115CSNK2A10.38076287
116CHEK20.37817592
117RAF10.35955140
118MAP2K60.35610787
119CHEK10.35560753
120SIK30.35478294
121KSR20.35289436
122CDK11A0.35230443
123FGFR10.34804212
124AKT20.33613010
125TEC0.33510909
126CSNK2A20.33015322
127CSF1R0.32838364
128MAP3K50.32535501

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.94111059
2Ribosome_Homo sapiens_hsa030103.76067485
3Proteasome_Homo sapiens_hsa030503.40591443
4Mismatch repair_Homo sapiens_hsa034302.78083793
5One carbon pool by folate_Homo sapiens_hsa006702.41305941
6Base excision repair_Homo sapiens_hsa034102.36822535
7Spliceosome_Homo sapiens_hsa030402.21279973
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.05336582
9RNA transport_Homo sapiens_hsa030131.99094539
10Pyrimidine metabolism_Homo sapiens_hsa002401.97995204
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.94304292
12RNA polymerase_Homo sapiens_hsa030201.79730707
13Nucleotide excision repair_Homo sapiens_hsa034201.75427396
14Cell cycle_Homo sapiens_hsa041101.67929064
15Pentose phosphate pathway_Homo sapiens_hsa000301.58350552
16Oxidative phosphorylation_Homo sapiens_hsa001901.53953749
17Homologous recombination_Homo sapiens_hsa034401.53438146
18Biosynthesis of amino acids_Homo sapiens_hsa012301.51792238
19Drug metabolism - other enzymes_Homo sapiens_hsa009831.47187224
20Sulfur relay system_Homo sapiens_hsa041221.47008464
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.46185364
22Folate biosynthesis_Homo sapiens_hsa007901.43341501
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.34619109
24p53 signaling pathway_Homo sapiens_hsa041151.32543170
25Legionellosis_Homo sapiens_hsa051341.31490332
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.30653560
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.27530479
28Carbon metabolism_Homo sapiens_hsa012001.22851550
29Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.21817876
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.21542136
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.19292895
32Antigen processing and presentation_Homo sapiens_hsa046121.15629243
33Glutathione metabolism_Homo sapiens_hsa004801.15582316
34Galactose metabolism_Homo sapiens_hsa000521.14441880
35Selenocompound metabolism_Homo sapiens_hsa004501.12832779
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12447909
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.11726021
38Huntingtons disease_Homo sapiens_hsa050161.07685644
39Shigellosis_Homo sapiens_hsa051311.05964066
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01585896
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00856631
42Vibrio cholerae infection_Homo sapiens_hsa051100.98325648
43Leishmaniasis_Homo sapiens_hsa051400.96596730
44Sulfur metabolism_Homo sapiens_hsa009200.95963392
45Epstein-Barr virus infection_Homo sapiens_hsa051690.95264928
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94705565
47Fructose and mannose metabolism_Homo sapiens_hsa000510.93712736
48Apoptosis_Homo sapiens_hsa042100.86397320
49Herpes simplex infection_Homo sapiens_hsa051680.84324405
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83616111
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83226612
52Bladder cancer_Homo sapiens_hsa052190.82038575
53Fatty acid elongation_Homo sapiens_hsa000620.81844493
54Alzheimers disease_Homo sapiens_hsa050100.77479052
55Viral carcinogenesis_Homo sapiens_hsa052030.77229670
56Thyroid cancer_Homo sapiens_hsa052160.75170848
57RNA degradation_Homo sapiens_hsa030180.73717614
58N-Glycan biosynthesis_Homo sapiens_hsa005100.71938813
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71481429
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69358793
61Allograft rejection_Homo sapiens_hsa053300.67264059
62Fat digestion and absorption_Homo sapiens_hsa049750.66772317
63Small cell lung cancer_Homo sapiens_hsa052220.66697180
64Graft-versus-host disease_Homo sapiens_hsa053320.65653921
65HTLV-I infection_Homo sapiens_hsa051660.65071582
66Vitamin B6 metabolism_Homo sapiens_hsa007500.63520096
67Pancreatic cancer_Homo sapiens_hsa052120.63314886
68Other glycan degradation_Homo sapiens_hsa005110.63210771
69Purine metabolism_Homo sapiens_hsa002300.62890554
70Systemic lupus erythematosus_Homo sapiens_hsa053220.62803898
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61738847
72Caffeine metabolism_Homo sapiens_hsa002320.61356529
73Renin-angiotensin system_Homo sapiens_hsa046140.60702431
74Measles_Homo sapiens_hsa051620.58065365
75Autoimmune thyroid disease_Homo sapiens_hsa053200.58050724
76Prion diseases_Homo sapiens_hsa050200.57871388
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55507112
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.54896920
79Chronic myeloid leukemia_Homo sapiens_hsa052200.53843252
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.53640183
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53102450
82Protein export_Homo sapiens_hsa030600.52617311
83mRNA surveillance pathway_Homo sapiens_hsa030150.52541411
84Primary immunodeficiency_Homo sapiens_hsa053400.50161130
85Non-small cell lung cancer_Homo sapiens_hsa052230.49729311
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.48918823
87HIF-1 signaling pathway_Homo sapiens_hsa040660.48754259
88Hepatitis B_Homo sapiens_hsa051610.48422753
89Pertussis_Homo sapiens_hsa051330.47476857
90Pyruvate metabolism_Homo sapiens_hsa006200.46511610
91Influenza A_Homo sapiens_hsa051640.46493405
92Non-homologous end-joining_Homo sapiens_hsa034500.46219896
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46047488
94Arginine and proline metabolism_Homo sapiens_hsa003300.45702777
95Acute myeloid leukemia_Homo sapiens_hsa052210.45475966
96Viral myocarditis_Homo sapiens_hsa054160.43696293
97B cell receptor signaling pathway_Homo sapiens_hsa046620.43043928
98Metabolic pathways_Homo sapiens_hsa011000.41873752
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.41051343
100Toxoplasmosis_Homo sapiens_hsa051450.40344609
101Intestinal immune network for IgA production_Homo sapiens_hsa046720.39851287
102Staphylococcus aureus infection_Homo sapiens_hsa051500.38833828
103Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37691746
104Toll-like receptor signaling pathway_Homo sapiens_hsa046200.37592820
105Arginine biosynthesis_Homo sapiens_hsa002200.36812155
106Hepatitis C_Homo sapiens_hsa051600.35986553
107Salmonella infection_Homo sapiens_hsa051320.35963872
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35286982
109Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35050420
110Lysosome_Homo sapiens_hsa041420.34011167
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34001120
112Phenylalanine metabolism_Homo sapiens_hsa003600.33703860
113Fanconi anemia pathway_Homo sapiens_hsa034600.33303721
114Rheumatoid arthritis_Homo sapiens_hsa053230.32960515
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32717870
116Tuberculosis_Homo sapiens_hsa051520.32536187
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31982319
118Parkinsons disease_Homo sapiens_hsa050120.31226218
119Malaria_Homo sapiens_hsa051440.31155124
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30578740

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