ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cytidine metabolic process (GO:0046087)	6.81663350
2	cytidine catabolic process (GO:0006216)	6.81663350
3	cytidine deamination (GO:0009972)	6.81663350
4	DNA deamination (GO:0045006)	6.37652266
5	pyrimidine ribonucleoside catabolic process (GO:0046133)	6.03870520
6	proteasome assembly (GO:0043248)	5.50729819
7	protein neddylation (GO:0045116)	5.49356586
8	positive regulation of T cell apoptotic process (GO:0070234)	5.40987708
9	eosinophil chemotaxis (GO:0048245)	5.38700334
10	macrophage chemotaxis (GO:0048246)	5.35301674
11	negative regulation by host of viral transcription (GO:0043922)	5.28383613
12	sequestering of actin monomers (GO:0042989)	5.21390992
13	eosinophil migration (GO:0072677)	4.85021045
14	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.52885982
15	positive regulation of lymphocyte apoptotic process (GO:0070230)	4.51665052
16	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	4.51611741
17	piRNA metabolic process (GO:0034587)	4.36090735
18	negative regulation of T cell differentiation in thymus (GO:0033085)	4.28164129
19	tryptophan catabolic process (GO:0006569)	4.11174849
20	indole-containing compound catabolic process (GO:0042436)	4.11174849
21	indolalkylamine catabolic process (GO:0046218)	4.11174849
22	male meiosis (GO:0007140)	4.10468308
23	regulation of lymphocyte chemotaxis (GO:1901623)	4.01018358
24	positive regulation of action potential (GO:0045760)	3.95035078
25	monocyte chemotaxis (GO:0002548)	3.88538887
26	kynurenine metabolic process (GO:0070189)	3.80285593
27	synapsis (GO:0007129)	3.72973115
28	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.72884919
29	positive regulation of tolerance induction (GO:0002645)	3.72666769
30	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.72647246
31	regulation of mitochondrial translation (GO:0070129)	3.66694567
32	positive regulation of cellular response to oxidative stress (GO:1900409)	3.62208202
33	positive regulation of response to oxidative stress (GO:1902884)	3.62208202
34	chaperone-mediated protein transport (GO:0072321)	3.48881380
35	regulation of T cell tolerance induction (GO:0002664)	3.46523809
36	tryptophan metabolic process (GO:0006568)	3.46222582
37	negative regulation of organelle assembly (GO:1902116)	3.38151128
38	protein complex biogenesis (GO:0070271)	3.36632930
39	ATP synthesis coupled proton transport (GO:0015986)	3.35472867
40	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.35472867
41	DNA methylation involved in gamete generation (GO:0043046)	3.30458789
42	male meiosis I (GO:0007141)	3.24726290
43	regulation of transcription from RNA polymerase I promoter (GO:0006356)	3.24161600
44	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.24038583
45	positive regulation of calcium-mediated signaling (GO:0050850)	3.22346220
46	regulation of chemokine-mediated signaling pathway (GO:0070099)	3.16760954
47	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.13669772
48	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.13669772
49	NADH dehydrogenase complex assembly (GO:0010257)	3.13669772
50	respiratory electron transport chain (GO:0022904)	3.13450805
51	positive regulation of lymphocyte migration (GO:2000403)	3.10535257
52	electron transport chain (GO:0022900)	3.10366053
53	central nervous system myelination (GO:0022010)	3.09926931
54	axon ensheathment in central nervous system (GO:0032291)	3.09926931
55	opioid receptor signaling pathway (GO:0038003)	3.09424425
56	base-excision repair, AP site formation (GO:0006285)	3.07965138
57	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.07597591
58	negative regulation of ligase activity (GO:0051352)	3.07597591
59	mitochondrial respiratory chain complex assembly (GO:0033108)	3.07444086
60	positive regulation of prostaglandin secretion (GO:0032308)	3.02192922
61	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.95282118
62	regulation of cellular amino acid metabolic process (GO:0006521)	2.94813649
63	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.91477280
64	transcription from mitochondrial promoter (GO:0006390)	2.90001828
65	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.89690668
66	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.89149159
67	positive regulation of steroid hormone secretion (GO:2000833)	2.88065852
68	DNA demethylation (GO:0080111)	2.87514943
69	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.87295460
70	regulation of glucocorticoid secretion (GO:2000849)	2.86381336
71	positive regulation of leukocyte apoptotic process (GO:2000108)	2.84996308
72	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.84803081
73	positive regulation of ligase activity (GO:0051351)	2.83801247
74	DNA double-strand break processing (GO:0000729)	2.81525180
75	inner mitochondrial membrane organization (GO:0007007)	2.80144733
76	regulation of lymphocyte migration (GO:2000401)	2.79986586
77	regulation of chronic inflammatory response (GO:0002676)	2.78988207
78	meiosis I (GO:0007127)	2.78423370
79	macroautophagy (GO:0016236)	2.78019035
80	regulation of mononuclear cell migration (GO:0071675)	2.77898339
81	retinal ganglion cell axon guidance (GO:0031290)	2.74551364
82	negative regulation of T cell receptor signaling pathway (GO:0050860)	2.71421281
83	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.71387410
84	cellular response to interleukin-15 (GO:0071350)	2.69539005
85	positive regulation of DNA repair (GO:0045739)	2.67799631
86	negative regulation of astrocyte differentiation (GO:0048712)	2.67373153
87	regulation of tolerance induction (GO:0002643)	2.66005637
88	positive regulation of cell cycle arrest (GO:0071158)	2.63753840
89	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.62743971
90	regulation of T cell apoptotic process (GO:0070232)	2.62643075
91	pyrimidine nucleoside catabolic process (GO:0046135)	2.62557884
92	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.60459568
93	aromatic amino acid family catabolic process (GO:0009074)	2.59695834
94	protein homotrimerization (GO:0070207)	2.57970660
95	regulation of activation of Janus kinase activity (GO:0010533)	2.57915026
96	regulation of ubiquitin-protein transferase activity (GO:0051438)	2.57499685
97	regulation of double-strand break repair via homologous recombination (GO:0010569)	2.56131055
98	cellular biogenic amine catabolic process (GO:0042402)	2.56020553
99	amine catabolic process (GO:0009310)	2.56020553
100	negative regulation of interleukin-1 beta production (GO:0032691)	2.55973564

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	7.15865844
2	EZH2_22144423_ChIP-Seq_EOC_Human	5.48749160
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.85809367
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.65446232
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.57689585
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.25848891
7	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.09944778
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.97120341
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.93129610
10	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.90298535
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.70797638
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.40494617
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.20735713
14	HTT_18923047_ChIP-ChIP_STHdh_Human	2.18590278
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.15524201
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.07041214
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.88967705
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.84282743
19	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.72525942
20	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.70724743
21	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.70360478
22	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.64467484
23	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.63789443
24	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.63429157
25	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.63253448
26	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.60192412
27	AR_21572438_ChIP-Seq_LNCaP_Human	1.59561180
28	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.59524044
29	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.56520459
30	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.54709756
31	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.51676241
32	VDR_23849224_ChIP-Seq_CD4+_Human	1.48617438
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.46157924
34	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.43653696
35	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.42655553
36	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.41549867
37	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.41366629
38	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.38010355
39	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.35221998
40	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.34321982
41	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.32704847
42	P300_19829295_ChIP-Seq_ESCs_Human	1.31821616
43	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.30452698
44	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.28259279
45	TP53_22573176_ChIP-Seq_HFKS_Human	1.26543954
46	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.26296510
47	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.25948482
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.22912261
49	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.22315229
50	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.20878025
51	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.17728659
52	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.17515321
53	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.16483632
54	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.09172543
55	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.09172543
56	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.06604294
57	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.05519913
58	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.04886252
59	TAF15_26573619_Chip-Seq_HEK293_Human	1.04424842
60	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02399486
61	FUS_26573619_Chip-Seq_HEK293_Human	1.02009020
62	AR_20517297_ChIP-Seq_VCAP_Human	1.00976808
63	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99280258
64	GABP_19822575_ChIP-Seq_HepG2_Human	0.97673819
65	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.97392011
66	NANOG_19829295_ChIP-Seq_ESCs_Human	0.97045556
67	SOX2_19829295_ChIP-Seq_ESCs_Human	0.97045556
68	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.94948104
69	AR_25329375_ChIP-Seq_VCAP_Human	0.93155816
70	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.92997273
71	ELK1_19687146_ChIP-ChIP_HELA_Human	0.92409707
72	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.92310180
73	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.92230550
74	GATA3_27048872_Chip-Seq_THYMUS_Human	0.91278368
75	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.90821684
76	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.88167738
77	GATA3_26560356_Chip-Seq_TH2_Human	0.86656834
78	VDR_22108803_ChIP-Seq_LS180_Human	0.86209702
79	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.85690122
80	FLI1_21867929_ChIP-Seq_CD8_Mouse	0.84908030
81	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.84146304
82	RNF2_27304074_Chip-Seq_NSC_Mouse	0.83839505
83	BCAT_22108803_ChIP-Seq_LS180_Human	0.83423923
84	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.82774759
85	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.82066560
86	SMAD1_18555785_Chip-Seq_ESCs_Mouse	0.81986611
87	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.81867440
88	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.81500055
89	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.81203803
90	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.80983147
91	ERG_20517297_ChIP-Seq_VCAP_Human	0.80850111
92	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.80599155
93	ZFX_18555785_Chip-Seq_ESCs_Mouse	0.80151163
94	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.80102960
95	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.79733211
96	REST_19997604_ChIP-ChIP_NEURONS_Mouse	0.78722562
97	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.77716342
98	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.77715375
99	CTCF_18555785_Chip-Seq_ESCs_Mouse	0.77629536
100	FOXP3_21729870_ChIP-Seq_TREG_Human	0.77216722

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.60564480
2	MP0008875_abnormal_xenobiotic_pharmacok	2.97952574
3	MP0004145_abnormal_muscle_electrophysio	2.73301088
4	MP0003786_premature_aging	2.41025933
5	MP0005310_abnormal_salivary_gland	2.35155355
6	MP0000538_abnormal_urinary_bladder	2.29371410
7	MP0009333_abnormal_splenocyte_physiolog	2.27667864
8	MP0000372_irregular_coat_pigmentation	2.14342565
9	MP0001905_abnormal_dopamine_level	2.12283987
10	MP0003763_abnormal_thymus_physiology	2.10639163
11	MP0006072_abnormal_retinal_apoptosis	2.09193190
12	MP0006082_CNS_inflammation	2.08373178
13	MP0001188_hyperpigmentation	2.06415477
14	MP0002751_abnormal_autonomic_nervous	2.05477878
15	MP0005389_reproductive_system_phenotype	2.01479194
16	MP0008995_early_reproductive_senescence	1.92776676
17	MP0000566_synostosis	1.90390369
18	MP0002160_abnormal_reproductive_system	1.89970666
19	MP0009046_muscle_twitch	1.88041734
20	MP0001984_abnormal_olfaction	1.82054693
21	MP0003252_abnormal_bile_duct	1.78489659
22	MP0009745_abnormal_behavioral_response	1.72489703
23	MP0003186_abnormal_redox_activity	1.71087719
24	MP0009780_abnormal_chondrocyte_physiolo	1.66389528
25	MP0008007_abnormal_cellular_replicative	1.65951176
26	MP0001501_abnormal_sleep_pattern	1.63060761
27	MP0004147_increased_porphyrin_level	1.62140740
28	MP0004215_abnormal_myocardial_fiber	1.61708655
29	MP0005085_abnormal_gallbladder_physiolo	1.59573068
30	MP0001919_abnormal_reproductive_system	1.58585709
31	MP0010307_abnormal_tumor_latency	1.49196569
32	MP0002277_abnormal_respiratory_mucosa	1.48332557
33	MP0002837_dystrophic_cardiac_calcinosis	1.48147113
34	MP0008877_abnormal_DNA_methylation	1.41264849
35	MP0004742_abnormal_vestibular_system	1.38333438
36	MP0003283_abnormal_digestive_organ	1.37158753
37	MP0002638_abnormal_pupillary_reflex	1.36762409
38	MP0002210_abnormal_sex_determination	1.35167839
39	MP0008961_abnormal_basal_metabolism	1.31887074
40	MP0000749_muscle_degeneration	1.29482555
41	MP0003646_muscle_fatigue	1.27486986
42	MP0005386_behavior/neurological_phenoty	1.25085202
43	MP0004924_abnormal_behavior	1.25085202
44	MP0001502_abnormal_circadian_rhythm	1.19853403
45	MP0004142_abnormal_muscle_tone	1.13432890
46	MP0008058_abnormal_DNA_repair	1.13251486
47	MP0001929_abnormal_gametogenesis	1.09869586
48	MP0010386_abnormal_urinary_bladder	1.08570667
49	MP0003137_abnormal_impulse_conducting	1.07991605
50	MP0002928_abnormal_bile_duct	1.04579041
51	MP0001800_abnormal_humoral_immune	1.04516872
52	MP0005253_abnormal_eye_physiology	1.03713456
53	MP0000653_abnormal_sex_gland	1.02810417
54	MP0001970_abnormal_pain_threshold	1.02759524
55	MP0005387_immune_system_phenotype	1.01731987
56	MP0001790_abnormal_immune_system	1.01731987
57	MP0005623_abnormal_meninges_morphology	1.00534989
58	MP0001486_abnormal_startle_reflex	1.00356884
59	MP0002148_abnormal_hypersensitivity_rea	0.98530917
60	MP0003936_abnormal_reproductive_system	0.96351247
61	MP0001542_abnormal_bone_strength	0.95133755
62	MP0001958_emphysema	0.94820592
63	MP0002067_abnormal_sensory_capabilities	0.94629305
64	MP0002184_abnormal_innervation	0.93762659
65	MP0002420_abnormal_adaptive_immunity	0.93562865
66	MP0003718_maternal_effect	0.92013774
67	MP0001819_abnormal_immune_cell	0.91480084
68	MP0002249_abnormal_larynx_morphology	0.91344554
69	MP0010094_abnormal_chromosome_stability	0.90937138
70	MP0002723_abnormal_immune_serum	0.90661064
71	MP0000703_abnormal_thymus_morphology	0.89633307
72	MP0002272_abnormal_nervous_system	0.89264338
73	MP0004885_abnormal_endolymph	0.88663123
74	MP0002733_abnormal_thermal_nociception	0.88559357
75	MP0001764_abnormal_homeostasis	0.88239451
76	MP0004484_altered_response_of	0.87299458
77	MP0001145_abnormal_male_reproductive	0.87026004
78	MP0003698_abnormal_male_reproductive	0.86303591
79	MP0003136_yellow_coat_color	0.85028823
80	MP0001119_abnormal_female_reproductive	0.84780408
81	MP0006036_abnormal_mitochondrial_physio	0.81954916
82	MP0004036_abnormal_muscle_relaxation	0.80948213
83	MP0005646_abnormal_pituitary_gland	0.80846712
84	MP0001529_abnormal_vocalization	0.80704042
85	MP0003959_abnormal_lean_body	0.77749926
86	MP0002398_abnormal_bone_marrow	0.76980662
87	MP0005174_abnormal_tail_pigmentation	0.76507973
88	MP0003195_calcinosis	0.74168604
89	MP0002822_catalepsy	0.73522902
90	MP0002909_abnormal_adrenal_gland	0.73010090
91	MP0000631_abnormal_neuroendocrine_gland	0.72927676
92	MP0003693_abnormal_embryo_hatching	0.71343410
93	MP0006035_abnormal_mitochondrial_morpho	0.70974452
94	MP0001727_abnormal_embryo_implantation	0.70181170
95	MP0000716_abnormal_immune_system	0.70082267
96	MP0000689_abnormal_spleen_morphology	0.69347716
97	MP0009785_altered_susceptibility_to	0.68634659
98	MP0002405_respiratory_system_inflammati	0.68206831
99	MP0005000_abnormal_immune_tolerance	0.68191113
100	MP0002064_seizures	0.67695672

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type I transferrin isoform profile (HP:0003642)	4.88498672
2	Gastrointestinal infarctions (HP:0005244)	4.74099619
3	Acute hepatic failure (HP:0006554)	4.47502829
4	Elevated erythrocyte sedimentation rate (HP:0003565)	4.19104915
5	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	4.01885473
6	Abnormal protein N-linked glycosylation (HP:0012347)	4.01885473
7	Abnormal protein glycosylation (HP:0012346)	4.01885473
8	Abnormal glycosylation (HP:0012345)	4.01885473
9	Optic neuritis (HP:0100653)	3.42916099
10	Retrobulbar optic neuritis (HP:0100654)	3.42916099
11	Arthropathy (HP:0003040)	3.41228575
12	Acute necrotizing encephalopathy (HP:0006965)	3.37258252
13	Amniotic constriction ring (HP:0009775)	3.25683412
14	Abnormality of placental membranes (HP:0011409)	3.25683412
15	Mitochondrial inheritance (HP:0001427)	3.20066102
16	Type 2 muscle fiber atrophy (HP:0003554)	3.14382500
17	Hemiplegia (HP:0002301)	3.09559286
18	Abnormality of T cell number (HP:0011839)	3.08126836
19	Hypoproteinemia (HP:0003075)	2.97468578
20	Increased CSF lactate (HP:0002490)	2.95855964
21	Abnormal mitochondria in muscle tissue (HP:0008316)	2.88492040
22	T lymphocytopenia (HP:0005403)	2.86860691
23	Acute encephalopathy (HP:0006846)	2.80201275
24	Orchitis (HP:0100796)	2.79638406
25	Abnormality of the prostate (HP:0008775)	2.77759583
26	Progressive macrocephaly (HP:0004481)	2.73521678
27	Hyperalaninemia (HP:0003348)	2.71873878
28	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.71873878
29	Abnormality of alanine metabolism (HP:0010916)	2.71873878
30	Abnormality of lateral ventricle (HP:0030047)	2.63448310
31	Myositis (HP:0100614)	2.62406459
32	Short tibia (HP:0005736)	2.62350075
33	Carpal bone hypoplasia (HP:0001498)	2.61082246
34	Renal Fanconi syndrome (HP:0001994)	2.60882638
35	Muscle fiber atrophy (HP:0100295)	2.60263596
36	Increased hepatocellular lipid droplets (HP:0006565)	2.57544324
37	Gangrene (HP:0100758)	2.55440371
38	Amyotrophic lateral sclerosis (HP:0007354)	2.52255071
39	Absent/shortened dynein arms (HP:0200106)	2.48951453
40	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.48951453
41	Severe visual impairment (HP:0001141)	2.47196293
42	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.46425441
43	IgG deficiency (HP:0004315)	2.45462022
44	Horizontal nystagmus (HP:0000666)	2.36764196
45	Lipid accumulation in hepatocytes (HP:0006561)	2.35098191
46	Diastasis recti (HP:0001540)	2.34408803
47	Optic disc pallor (HP:0000543)	2.32007508
48	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.24847175
49	Ulnar claw (HP:0001178)	2.24802589
50	Keratoconjunctivitis sicca (HP:0001097)	2.20713417
51	Beaking of vertebral bodies (HP:0004568)	2.20547601
52	Fibular aplasia (HP:0002990)	2.17743628
53	Gonadotropin excess (HP:0000837)	2.17659714
54	Aplasia/hypoplasia of the uterus (HP:0008684)	2.17217052
55	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.17137284
56	Encephalitis (HP:0002383)	2.13343296
57	Cerebral edema (HP:0002181)	2.09699900
58	Abnormal number of incisors (HP:0011064)	2.08865937
59	Distal arthrogryposis (HP:0005684)	2.08137222
60	Peritonitis (HP:0002586)	2.08115786
61	Molar tooth sign on MRI (HP:0002419)	2.07931454
62	Abnormality of midbrain morphology (HP:0002418)	2.07931454
63	Posterior subcapsular cataract (HP:0007787)	2.06977323
64	Abnormality of abdominal situs (HP:0011620)	2.05155570
65	Abdominal situs inversus (HP:0003363)	2.05155570
66	Abnormal ciliary motility (HP:0012262)	2.03819548
67	Abolished electroretinogram (ERG) (HP:0000550)	2.01533950
68	Increased intramyocellular lipid droplets (HP:0012240)	1.99596530
69	Increased serum lactate (HP:0002151)	1.97667479
70	Episodic fever (HP:0001954)	1.95975224
71	Aplasia involving bones of the extremities (HP:0009825)	1.95408802
72	Aplasia involving bones of the upper limbs (HP:0009823)	1.95408802
73	Aplasia of the phalanges of the hand (HP:0009802)	1.95408802
74	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.94769782
75	Hepatocellular necrosis (HP:0001404)	1.94763775
76	Keratoconjunctivitis (HP:0001096)	1.92305375
77	Popliteal pterygium (HP:0009756)	1.91807456
78	Hypoplasia of the uterus (HP:0000013)	1.91776020
79	Chest pain (HP:0100749)	1.91510581
80	Fetal akinesia sequence (HP:0001989)	1.91070324
81	Abnormality of male internal genitalia (HP:0000022)	1.91042581
82	True hermaphroditism (HP:0010459)	1.90929197
83	Nephronophthisis (HP:0000090)	1.89644464
84	Abnormal respiratory motile cilium morphology (HP:0005938)	1.89566636
85	Abnormal respiratory epithelium morphology (HP:0012253)	1.89566636
86	Abnormality of the middle phalanges of the toes (HP:0010183)	1.88353556
87	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.87385541
88	Pancreatic cysts (HP:0001737)	1.87040636
89	Abnormality of T cells (HP:0002843)	1.84646717
90	Malignant hyperthermia (HP:0002047)	1.83746089
91	Attenuation of retinal blood vessels (HP:0007843)	1.82944896
92	Pendular nystagmus (HP:0012043)	1.82290911
93	Hemoptysis (HP:0002105)	1.81304789
94	Febrile seizures (HP:0002373)	1.81291195
95	Thyroiditis (HP:0100646)	1.79596642
96	X-linked dominant inheritance (HP:0001423)	1.79095932
97	Increased IgM level (HP:0003496)	1.78859946
98	Increased serum pyruvate (HP:0003542)	1.77273327
99	Lactic acidosis (HP:0003128)	1.77259370
100	Leukocytosis (HP:0001974)	1.77020996

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.30917372
2	PNCK	4.24345330
3	ADRBK2	3.82667344
4	GRK7	3.16394649
5	KDR	2.95698650
6	BUB1	2.90888842
7	EIF2AK3	2.85696832
8	MET	2.80265825
9	CASK	2.78684187
10	ITK	2.15147667
11	BCKDK	2.04095881
12	NTRK1	2.02083186
13	PLK2	1.66955596
14	WNK3	1.66229069
15	EPHB2	1.64530401
16	TLK1	1.60443279
17	CSF1R	1.57876701
18	PTK2B	1.56849477
19	SRPK1	1.55750533
20	CDK19	1.54983033
21	MAP3K9	1.52135558
22	FRK	1.51110245
23	MAP4K2	1.49659689
24	NUAK1	1.49510678
25	MAPK13	1.48403056
26	DYRK3	1.48331526
27	BMX	1.44289588
28	PINK1	1.38453619
29	EPHA4	1.33324455
30	LIMK1	1.25726492
31	OXSR1	1.15763320
32	ERBB3	1.14430583
33	ZAK	1.10984579
34	CAMK1G	1.08424245
35	NEK1	1.07786051
36	EIF2AK1	1.04662311
37	FGR	1.04591166
38	ROCK1	1.02927157
39	PRKCQ	0.99871404
40	TSSK6	0.97967125
41	PDGFRB	0.93632440
42	FGFR1	0.92536911
43	STK39	0.86707400
44	SYK	0.84962332
45	MAP2K2	0.83200023
46	MAP4K1	0.82418733
47	VRK2	0.80692109
48	OBSCN	0.80001508
49	ERBB2	0.79923290
50	AURKA	0.77349026
51	NTRK2	0.76909816
52	PIK3CA	0.76399367
53	MATK	0.75386034
54	FGFR3	0.74826346
55	STK16	0.69198228
56	PASK	0.68639830
57	GRK1	0.68595990
58	VRK1	0.68553479
59	PDK2	0.61324412
60	LCK	0.60763209
61	MAP2K7	0.59780792
62	ATR	0.59484402
63	DYRK2	0.59250348
64	TYRO3	0.58460636
65	CAMK2A	0.57395033
66	IGF1R	0.53089728
67	MARK1	0.52504448
68	MKNK2	0.52210440
69	PRKCE	0.51339661
70	EGFR	0.50626134
71	WNK4	0.46863370
72	TESK2	0.45408632
73	INSR	0.43373087
74	BRSK2	0.43358841
75	ADRBK1	0.42293132
76	PHKG1	0.41203002
77	PHKG2	0.41203002
78	CDK3	0.40360280
79	RPS6KA5	0.37990951
80	RET	0.37684504
81	RPS6KA4	0.37204626
82	GRK6	0.37026059
83	CSNK2A1	0.36560669
84	CSNK1G3	0.35844933
85	INSRR	0.35841977
86	NTRK3	0.34456333
87	PRKACA	0.34163806
88	KSR1	0.33401476
89	PRKCA	0.32452405
90	ZAP70	0.32296760
91	BRSK1	0.32274631
92	PKN1	0.32089897
93	CSK	0.31393820
94	IKBKE	0.29923323
95	DYRK1A	0.28952152
96	RPS6KA1	0.27272150
97	STK38L	0.26225839
98	IKBKB	0.26069588
99	CSNK1E	0.25889009
100	WEE1	0.25563516

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	6.42201934
2	Proteasome_Homo sapiens_hsa03050	4.47070121
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.59861377
4	Parkinsons disease_Homo sapiens_hsa05012	3.50215428
5	Protein export_Homo sapiens_hsa03060	2.78967659
6	Cardiac muscle contraction_Homo sapiens_hsa04260	2.74555546
7	Primary immunodeficiency_Homo sapiens_hsa05340	2.60981706
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.42362035
9	Huntingtons disease_Homo sapiens_hsa05016	2.24949904
10	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.22869720
11	Alzheimers disease_Homo sapiens_hsa05010	2.20552462
12	Graft-versus-host disease_Homo sapiens_hsa05332	2.10278410
13	Allograft rejection_Homo sapiens_hsa05330	2.06772395
14	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.05936295
15	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.02287986
16	RNA polymerase_Homo sapiens_hsa03020	1.90886282
17	Antigen processing and presentation_Homo sapiens_hsa04612	1.77471674
18	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.47658062
19	Rheumatoid arthritis_Homo sapiens_hsa05323	1.44020434
20	Ribosome_Homo sapiens_hsa03010	1.43693416
21	Basal transcription factors_Homo sapiens_hsa03022	1.40320837
22	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.37615531
23	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.36159837
24	Mismatch repair_Homo sapiens_hsa03430	1.30486049
25	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.27998665
26	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.25357489
27	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.23464335
28	Type I diabetes mellitus_Homo sapiens_hsa04940	1.23247406
29	Phototransduction_Homo sapiens_hsa04744	1.19119708
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.12264768
31	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.07154723
32	Nucleotide excision repair_Homo sapiens_hsa03420	1.06513614
33	RNA degradation_Homo sapiens_hsa03018	1.06107408
34	Sulfur metabolism_Homo sapiens_hsa00920	1.04952810
35	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.02959775
36	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.01608955
37	Steroid biosynthesis_Homo sapiens_hsa00100	0.98428488
38	Chemical carcinogenesis_Homo sapiens_hsa05204	0.97859438
39	RNA transport_Homo sapiens_hsa03013	0.97739134
40	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.91640322
41	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.83994800
42	Tryptophan metabolism_Homo sapiens_hsa00380	0.81470404
43	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.79654320
44	Olfactory transduction_Homo sapiens_hsa04740	0.76685007
45	Measles_Homo sapiens_hsa05162	0.76115617
46	p53 signaling pathway_Homo sapiens_hsa04115	0.72913061
47	Linoleic acid metabolism_Homo sapiens_hsa00591	0.72557215
48	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.71034717
49	Peroxisome_Homo sapiens_hsa04146	0.69751966
50	Viral myocarditis_Homo sapiens_hsa05416	0.69011186
51	Salmonella infection_Homo sapiens_hsa05132	0.67825875
52	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.66089925
53	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.64631903
54	Spliceosome_Homo sapiens_hsa03040	0.64464760
55	Purine metabolism_Homo sapiens_hsa00230	0.61714904
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.60831846
57	Fanconi anemia pathway_Homo sapiens_hsa03460	0.60608258
58	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.60129035
59	Retinol metabolism_Homo sapiens_hsa00830	0.59647332
60	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.59484293
61	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.57230035
62	Ether lipid metabolism_Homo sapiens_hsa00565	0.53943864
63	Oocyte meiosis_Homo sapiens_hsa04114	0.51189968
64	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.50402306
65	Pyrimidine metabolism_Homo sapiens_hsa00240	0.50129075
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.49341629
67	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.47181721
68	Asthma_Homo sapiens_hsa05310	0.45426607
69	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.44628868
70	Metabolic pathways_Homo sapiens_hsa01100	0.43851181
71	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.43006912
72	Chemokine signaling pathway_Homo sapiens_hsa04062	0.42655240
73	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.37957018
74	Circadian rhythm_Homo sapiens_hsa04710	0.37392032
75	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.37327971
76	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.36633689
77	Prion diseases_Homo sapiens_hsa05020	0.36361093
78	Sphingolipid metabolism_Homo sapiens_hsa00600	0.33897860
79	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.33783579
80	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.31630799
81	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.30446801
82	Tyrosine metabolism_Homo sapiens_hsa00350	0.30043409
83	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.30022033
84	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.29551282
85	Taste transduction_Homo sapiens_hsa04742	0.29434178
86	Regulation of autophagy_Homo sapiens_hsa04140	0.29293087
87	DNA replication_Homo sapiens_hsa03030	0.28668365
88	Apoptosis_Homo sapiens_hsa04210	0.27553065
89	Nitrogen metabolism_Homo sapiens_hsa00910	0.27267710
90	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.25872098
91	Herpes simplex infection_Homo sapiens_hsa05168	0.25223898
92	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.21003383
93	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.20649828
94	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.20224126
95	Homologous recombination_Homo sapiens_hsa03440	0.19887777
96	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.17980617
97	Collecting duct acid secretion_Homo sapiens_hsa04966	0.17281925
98	Shigellosis_Homo sapiens_hsa05131	0.17276169
99	Base excision repair_Homo sapiens_hsa03410	0.17041160
100	Axon guidance_Homo sapiens_hsa04360	0.14455547

PRELID1P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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