ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	aggressive behavior (GO:0002118)	4.89153853
2	peptidyl-histidine modification (GO:0018202)	4.75551627
3	mitochondrion transport along microtubule (GO:0047497)	4.29754583
4	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	4.29754583
5	establishment of mitochondrion localization (GO:0051654)	3.99595508
6	behavioral response to nicotine (GO:0035095)	3.97123514
7	replication fork processing (GO:0031297)	3.93099139
8	DNA deamination (GO:0045006)	3.69517246
9	response to pheromone (GO:0019236)	3.67265135
10	respiratory chain complex IV assembly (GO:0008535)	3.59072694
11	cytochrome complex assembly (GO:0017004)	3.53330256
12	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.51131575
13	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.51131575
14	regulation of transmission of nerve impulse (GO:0051969)	3.49019598
15	parental behavior (GO:0060746)	3.42213123
16	platelet dense granule organization (GO:0060155)	3.40211094
17	pseudouridine synthesis (GO:0001522)	3.36445503
18	DNA double-strand break processing (GO:0000729)	3.35255488
19	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.34612460
20	maternal behavior (GO:0042711)	3.33458903
21	protein complex biogenesis (GO:0070271)	3.32600554
22	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.28813738
23	regulation of female receptivity (GO:0045924)	3.28121603
24	auditory receptor cell stereocilium organization (GO:0060088)	3.27516502
25	detection of light stimulus involved in sensory perception (GO:0050962)	3.22705522
26	detection of light stimulus involved in visual perception (GO:0050908)	3.22705522
27	positive regulation of amino acid transport (GO:0051957)	3.20474803
28	preassembly of GPI anchor in ER membrane (GO:0016254)	3.20367633
29	mitochondrial respiratory chain complex assembly (GO:0033108)	3.14957467
30	mannosylation (GO:0097502)	3.12705845
31	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.11161723
32	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.11161723
33	NADH dehydrogenase complex assembly (GO:0010257)	3.11161723
34	positive regulation of prostaglandin secretion (GO:0032308)	3.10094587
35	recombinational repair (GO:0000725)	3.09702374
36	mitochondrial RNA metabolic process (GO:0000959)	3.05903011
37	double-strand break repair via homologous recombination (GO:0000724)	3.04747414
38	anterograde synaptic vesicle transport (GO:0048490)	3.01822416
39	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.01160594
40	female mating behavior (GO:0060180)	2.99129417
41	piRNA metabolic process (GO:0034587)	2.94343538
42	zinc ion transmembrane transport (GO:0071577)	2.94260453
43	water-soluble vitamin biosynthetic process (GO:0042364)	2.94055988
44	negative regulation of neurological system process (GO:0031645)	2.93973003
45	C4-dicarboxylate transport (GO:0015740)	2.93937858
46	tRNA modification (GO:0006400)	2.93138968
47	transcription from mitochondrial promoter (GO:0006390)	2.92645848
48	meiotic chromosome segregation (GO:0045132)	2.91792007
49	seminiferous tubule development (GO:0072520)	2.91765703
50	protein-cofactor linkage (GO:0018065)	2.88138560
51	DNA methylation involved in gamete generation (GO:0043046)	2.87999952
52	L-fucose catabolic process (GO:0042355)	2.82193718
53	fucose catabolic process (GO:0019317)	2.82193718
54	L-fucose metabolic process (GO:0042354)	2.82193718
55	maturation of 5.8S rRNA (GO:0000460)	2.80818239
56	reciprocal meiotic recombination (GO:0007131)	2.80521417
57	reciprocal DNA recombination (GO:0035825)	2.80521417
58	tRNA processing (GO:0008033)	2.80110993
59	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.79696011
60	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.79696011
61	iron-sulfur cluster assembly (GO:0016226)	2.78581643
62	metallo-sulfur cluster assembly (GO:0031163)	2.78581643
63	cornea development in camera-type eye (GO:0061303)	2.76285568
64	kynurenine metabolic process (GO:0070189)	2.75088678
65	photoreceptor cell maintenance (GO:0045494)	2.73977813
66	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.73931503
67	amino acid salvage (GO:0043102)	2.73776641
68	L-methionine salvage (GO:0071267)	2.73776641
69	L-methionine biosynthetic process (GO:0071265)	2.73776641
70	behavioral response to ethanol (GO:0048149)	2.69389937
71	protein neddylation (GO:0045116)	2.68260694
72	inner ear receptor stereocilium organization (GO:0060122)	2.66251259
73	ubiquinone metabolic process (GO:0006743)	2.66144150
74	indole-containing compound catabolic process (GO:0042436)	2.65104505
75	indolalkylamine catabolic process (GO:0046218)	2.65104505
76	tryptophan catabolic process (GO:0006569)	2.65104505
77	zinc ion transport (GO:0006829)	2.64240665
78	positive regulation of organic acid transport (GO:0032892)	2.61054548
79	indolalkylamine metabolic process (GO:0006586)	2.60106610
80	male meiosis (GO:0007140)	2.57381493
81	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.54182916
82	cellular biogenic amine catabolic process (GO:0042402)	2.53965270
83	amine catabolic process (GO:0009310)	2.53965270
84	negative regulation of telomere maintenance (GO:0032205)	2.52036262
85	regulation of glutamate secretion (GO:0014048)	2.48944356
86	methionine biosynthetic process (GO:0009086)	2.47374987
87	regulation of cilium movement (GO:0003352)	2.47315219
88	tRNA methylation (GO:0030488)	2.47086621
89	nonmotile primary cilium assembly (GO:0035058)	2.46450382
90	autophagic vacuole fusion (GO:0000046)	2.46092084
91	cellular ketone body metabolic process (GO:0046950)	2.45687534
92	GMP metabolic process (GO:0046037)	2.44776828
93	gamma-aminobutyric acid transport (GO:0015812)	2.43165441
94	branched-chain amino acid catabolic process (GO:0009083)	2.42922747
95	viral mRNA export from host cell nucleus (GO:0046784)	2.41702763
96	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.41542266
97	protein K6-linked ubiquitination (GO:0085020)	2.39497892
98	intraciliary transport (GO:0042073)	2.38930983
99	ketone body metabolic process (GO:1902224)	2.38056871
100	dopamine transport (GO:0015872)	2.35501151

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.30344438
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.89875477
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.45310235
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.28250208
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.93037460
6	VDR_22108803_ChIP-Seq_LS180_Human	2.70590618
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.57128228
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.51296740
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.51237312
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.40604095
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.30529868
12	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.25412494
13	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.23056395
14	GBX2_23144817_ChIP-Seq_PC3_Human	2.21640630
15	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.21529124
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.18736404
17	MYC_18940864_ChIP-ChIP_HL60_Human	2.05960744
18	VDR_23849224_ChIP-Seq_CD4+_Human	2.03474462
19	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.01019897
20	EWS_26573619_Chip-Seq_HEK293_Human	1.92594944
21	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.88551511
22	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.88359067
23	EZH2_22144423_ChIP-Seq_EOC_Human	1.81071987
24	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.79602022
25	TP53_22573176_ChIP-Seq_HFKS_Human	1.76577023
26	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.73720221
27	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.69054937
28	ELK1_19687146_ChIP-ChIP_HELA_Human	1.68294454
29	FUS_26573619_Chip-Seq_HEK293_Human	1.67344057
30	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.61672300
31	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.61061044
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.59934979
33	FOXP3_21729870_ChIP-Seq_TREG_Human	1.59427669
34	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.59275414
35	GABP_19822575_ChIP-Seq_HepG2_Human	1.57943457
36	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.53211987
37	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.52612009
38	P300_19829295_ChIP-Seq_ESCs_Human	1.47584296
39	ER_23166858_ChIP-Seq_MCF-7_Human	1.44930677
40	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.35857323
41	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35261936
42	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.31444953
43	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.30659637
44	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29609208
45	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29609208
46	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.28400216
47	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.26956391
48	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.26372748
49	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.26372748
50	BCAT_22108803_ChIP-Seq_LS180_Human	1.21257774
51	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.19283752
52	AR_20517297_ChIP-Seq_VCAP_Human	1.18433162
53	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.17977934
54	CBP_20019798_ChIP-Seq_JUKART_Human	1.16102104
55	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.16102104
56	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.15849672
57	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.15349196
58	KDM5A_27292631_Chip-Seq_BREAST_Human	1.15340687
59	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.13270126
60	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.11869234
61	TAF15_26573619_Chip-Seq_HEK293_Human	1.11691378
62	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.11085643
63	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.10020558
64	P53_21459846_ChIP-Seq_SAOS-2_Human	1.09950369
65	RNF2_27304074_Chip-Seq_NSC_Mouse	1.06882998
66	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.06298153
67	NCOR_22424771_ChIP-Seq_293T_Human	1.05904122
68	HOXB7_26014856_ChIP-Seq_BT474_Human	1.05694409
69	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.05044363
70	STAT3_23295773_ChIP-Seq_U87_Human	1.05039696
71	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.04160056
72	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.04074572
73	REST_21632747_ChIP-Seq_MESCs_Mouse	1.03446061
74	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.03256712
75	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.02881426
76	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.02824033
77	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.99730063
78	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.99218413
79	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.97892333
80	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.96432738
81	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96326989
82	ERA_21632823_ChIP-Seq_H3396_Human	0.96260402
83	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.96238903
84	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.96079198
85	TCF4_23295773_ChIP-Seq_U87_Human	0.95393625
86	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95126756
87	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.95126756
88	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.94950266
89	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.94242684
90	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.94093013
91	MYC_19829295_ChIP-Seq_ESCs_Human	0.92705039
92	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.92658041
93	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.92594982
94	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.92477563
95	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.91147799
96	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.89940950
97	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.88673234
98	DCP1A_22483619_ChIP-Seq_HELA_Human	0.88505047
99	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.87696099
100	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.87177832

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005645_abnormal_hypothalamus_physiol	3.37555310
2	MP0006292_abnormal_olfactory_placode	3.13343222
3	MP0000372_irregular_coat_pigmentation	2.69104571
4	MP0001968_abnormal_touch/_nociception	2.60999606
5	MP0008058_abnormal_DNA_repair	2.54117499
6	MP0002736_abnormal_nociception_after	2.52078857
7	MP0005646_abnormal_pituitary_gland	2.44738461
8	MP0003718_maternal_effect	2.38391260
9	MP0005551_abnormal_eye_electrophysiolog	2.27581954
10	MP0003880_abnormal_central_pattern	2.27094969
11	MP0008877_abnormal_DNA_methylation	2.21997624
12	MP0000569_abnormal_digit_pigmentation	2.10065248
13	MP0002938_white_spotting	2.06779156
14	MP0008875_abnormal_xenobiotic_pharmacok	2.01801771
15	MP0002102_abnormal_ear_morphology	2.01661884
16	MP0006276_abnormal_autonomic_nervous	1.99383450
17	MP0001529_abnormal_vocalization	1.94701655
18	MP0009046_muscle_twitch	1.92959260
19	MP0003195_calcinosis	1.88055155
20	MP0002653_abnormal_ependyma_morphology	1.86625590
21	MP0010386_abnormal_urinary_bladder	1.85008128
22	MP0002234_abnormal_pharynx_morphology	1.83430782
23	MP0005174_abnormal_tail_pigmentation	1.81675323
24	MP0002638_abnormal_pupillary_reflex	1.76672253
25	MP0009278_abnormal_bone_marrow	1.73751100
26	MP0008872_abnormal_physiological_respon	1.67644049
27	MP0000015_abnormal_ear_pigmentation	1.66950731
28	MP0004147_increased_porphyrin_level	1.63699765
29	MP0005397_hematopoietic_system_phenotyp	1.62011269
30	MP0001545_abnormal_hematopoietic_system	1.62011269
31	MP0009745_abnormal_behavioral_response	1.60210047
32	MP0008057_abnormal_DNA_replication	1.58245120
33	MP0004133_heterotaxia	1.54288702
34	MP0005084_abnormal_gallbladder_morpholo	1.53809644
35	MP0001501_abnormal_sleep_pattern	1.49945891
36	MP0001486_abnormal_startle_reflex	1.47489719
37	MP0002272_abnormal_nervous_system	1.46383363
38	MP0003787_abnormal_imprinting	1.44261693
39	MP0005410_abnormal_fertilization	1.40410985
40	MP0002557_abnormal_social/conspecific_i	1.35674031
41	MP0010094_abnormal_chromosome_stability	1.35002395
42	MP0002254_reproductive_system_inflammat	1.34562880
43	MP0001764_abnormal_homeostasis	1.34442996
44	MP0002735_abnormal_chemical_nociception	1.34143201
45	MP0003786_premature_aging	1.33609323
46	MP0000631_abnormal_neuroendocrine_gland	1.33381420
47	MP0005253_abnormal_eye_physiology	1.32279340
48	MP0003806_abnormal_nucleotide_metabolis	1.30979847
49	MP0006036_abnormal_mitochondrial_physio	1.28286068
50	MP0006072_abnormal_retinal_apoptosis	1.26090478
51	MP0004142_abnormal_muscle_tone	1.24788311
52	MP0002160_abnormal_reproductive_system	1.24447856
53	MP0008995_early_reproductive_senescence	1.23557214
54	MP0002733_abnormal_thermal_nociception	1.21316483
55	MP0008789_abnormal_olfactory_epithelium	1.20430329
56	MP0003186_abnormal_redox_activity	1.19829053
57	MP0002095_abnormal_skin_pigmentation	1.18793399
58	MP0001970_abnormal_pain_threshold	1.16637705
59	MP0001986_abnormal_taste_sensitivity	1.11976387
60	MP0004742_abnormal_vestibular_system	1.10123618
61	MP0005075_abnormal_melanosome_morpholog	1.09582268
62	MP0002572_abnormal_emotion/affect_behav	1.07896040
63	MP0002837_dystrophic_cardiac_calcinosis	1.06973174
64	MP0003635_abnormal_synaptic_transmissio	1.05372221
65	MP0002064_seizures	1.04275963
66	MP0002876_abnormal_thyroid_physiology	1.03333370
67	MP0003698_abnormal_male_reproductive	1.01023822
68	MP0001984_abnormal_olfaction	0.97893920
69	MP0003136_yellow_coat_color	0.96735976
70	MP0004924_abnormal_behavior	0.95559406
71	MP0005386_behavior/neurological_phenoty	0.95559406
72	MP0000427_abnormal_hair_cycle	0.94311273
73	MP0002067_abnormal_sensory_capabilities	0.93226791
74	MP0003283_abnormal_digestive_organ	0.90551034
75	MP0001929_abnormal_gametogenesis	0.89650429
76	MP0001905_abnormal_dopamine_level	0.87178634
77	MP0002751_abnormal_autonomic_nervous	0.87099203
78	MP0002210_abnormal_sex_determination	0.86567984
79	MP0000653_abnormal_sex_gland	0.86250511
80	MP0004885_abnormal_endolymph	0.86173419
81	MP0002928_abnormal_bile_duct	0.85684687
82	MP0005394_taste/olfaction_phenotype	0.85568852
83	MP0005499_abnormal_olfactory_system	0.85568852
84	MP0006035_abnormal_mitochondrial_morpho	0.84969153
85	MP0008007_abnormal_cellular_replicative	0.84522326
86	MP0001293_anophthalmia	0.84406976
87	MP0000647_abnormal_sebaceous_gland	0.83342281
88	MP0005389_reproductive_system_phenotype	0.81168098
89	MP0002229_neurodegeneration	0.80468079
90	MP0000230_abnormal_systemic_arterial	0.79147800
91	MP0005670_abnormal_white_adipose	0.78399879
92	MP0005395_other_phenotype	0.77601005
93	MP0002752_abnormal_somatic_nervous	0.77103874
94	MP0003693_abnormal_embryo_hatching	0.76949484
95	MP0001963_abnormal_hearing_physiology	0.76709584
96	MP0003121_genomic_imprinting	0.76524791
97	MP0005195_abnormal_posterior_eye	0.75245246
98	MP0001145_abnormal_male_reproductive	0.75185693
99	MP0004145_abnormal_muscle_electrophysio	0.74759833
100	MP0003950_abnormal_plasma_membrane	0.72658507

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.82133826
2	Congenital stationary night blindness (HP:0007642)	3.52207397
3	Abnormality of midbrain morphology (HP:0002418)	3.49022396
4	Molar tooth sign on MRI (HP:0002419)	3.49022396
5	Pancreatic fibrosis (HP:0100732)	3.47754599
6	Nephronophthisis (HP:0000090)	3.26757157
7	Acute necrotizing encephalopathy (HP:0006965)	3.24007449
8	Abnormal rod and cone electroretinograms (HP:0008323)	3.17641748
9	True hermaphroditism (HP:0010459)	3.13101620
10	Microvesicular hepatic steatosis (HP:0001414)	3.12595365
11	Attenuation of retinal blood vessels (HP:0007843)	3.11737922
12	Decreased central vision (HP:0007663)	3.09590243
13	Mitochondrial inheritance (HP:0001427)	3.03411829
14	Acute encephalopathy (HP:0006846)	3.01936672
15	Abnormal mitochondria in muscle tissue (HP:0008316)	2.91189904
16	Increased CSF lactate (HP:0002490)	2.90646879
17	Abnormality of the renal medulla (HP:0100957)	2.89563373
18	Abnormal number of erythroid precursors (HP:0012131)	2.88603215
19	Progressive macrocephaly (HP:0004481)	2.81518852
20	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.81509813
21	Type II lissencephaly (HP:0007260)	2.67866088
22	Cerebral edema (HP:0002181)	2.67199785
23	Abnormality of the renal cortex (HP:0011035)	2.65731469
24	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.58980044
25	Abolished electroretinogram (ERG) (HP:0000550)	2.58483847
26	Hepatocellular necrosis (HP:0001404)	2.49247919
27	Medial flaring of the eyebrow (HP:0010747)	2.45397257
28	Ketoacidosis (HP:0001993)	2.39752228
29	Pendular nystagmus (HP:0012043)	2.33903931
30	Abnormality of the labia minora (HP:0012880)	2.33793497
31	Hepatic necrosis (HP:0002605)	2.32310646
32	Hyperglycinuria (HP:0003108)	2.29488125
33	Hemiparesis (HP:0001269)	2.28923574
34	Hyperthyroidism (HP:0000836)	2.28108503
35	Tubulointerstitial nephritis (HP:0001970)	2.27897896
36	Chronic hepatic failure (HP:0100626)	2.26134551
37	3-Methylglutaconic aciduria (HP:0003535)	2.24856641
38	Severe visual impairment (HP:0001141)	2.23807512
39	Abnormal biliary tract physiology (HP:0012439)	2.20546523
40	Bile duct proliferation (HP:0001408)	2.20546523
41	Hyperventilation (HP:0002883)	2.15183551
42	Cystic liver disease (HP:0006706)	2.13988102
43	Focal seizures (HP:0007359)	2.13136130
44	Ketosis (HP:0001946)	2.12788743
45	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.12375340
46	Chromsome breakage (HP:0040012)	2.10560856
47	Neoplasm of the adrenal cortex (HP:0100641)	2.09795457
48	Lactic acidosis (HP:0003128)	2.09524221
49	Abnormality of cells of the erythroid lineage (HP:0012130)	2.09320220
50	Progressive microcephaly (HP:0000253)	2.09162921
51	Cerebellar dysplasia (HP:0007033)	2.09118723
52	Optic disc pallor (HP:0000543)	2.07725403
53	Methylmalonic aciduria (HP:0012120)	2.07021907
54	Abnormality of DNA repair (HP:0003254)	2.06354539
55	Lipid accumulation in hepatocytes (HP:0006561)	2.05479315
56	Increased serum lactate (HP:0002151)	2.05087765
57	Focal motor seizures (HP:0011153)	2.03822972
58	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.02198854
59	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.02101318
60	Sclerocornea (HP:0000647)	2.01875453
61	Dicarboxylic aciduria (HP:0003215)	2.01625805
62	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.01625805
63	Metaphyseal dysplasia (HP:0100255)	2.01525459
64	Colon cancer (HP:0003003)	1.99639942
65	Gait imbalance (HP:0002141)	1.98928628
66	Renal cortical cysts (HP:0000803)	1.97640892
67	Congenital primary aphakia (HP:0007707)	1.96601689
68	Meckel diverticulum (HP:0002245)	1.94302329
69	Type 2 muscle fiber atrophy (HP:0003554)	1.93615322
70	Congenital hepatic fibrosis (HP:0002612)	1.92339433
71	Increased corneal curvature (HP:0100692)	1.91708150
72	Keratoconus (HP:0000563)	1.91708150
73	Inability to walk (HP:0002540)	1.90018443
74	Hyperglycinemia (HP:0002154)	1.88908158
75	Abnormal glycosylation (HP:0012345)	1.88010103
76	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.88010103
77	Abnormal protein N-linked glycosylation (HP:0012347)	1.88010103
78	Abnormal protein glycosylation (HP:0012346)	1.88010103
79	Retinal dysplasia (HP:0007973)	1.87902075
80	Febrile seizures (HP:0002373)	1.87168565
81	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.87077038
82	Bony spicule pigmentary retinopathy (HP:0007737)	1.85735843
83	Abnormality of the ileum (HP:0001549)	1.85419903
84	Nephrogenic diabetes insipidus (HP:0009806)	1.83505758
85	Flat capital femoral epiphysis (HP:0003370)	1.83315080
86	Postaxial foot polydactyly (HP:0001830)	1.82913784
87	Type I transferrin isoform profile (HP:0003642)	1.80349790
88	Severe muscular hypotonia (HP:0006829)	1.80298300
89	Tubular atrophy (HP:0000092)	1.79763940
90	Increased hepatocellular lipid droplets (HP:0006565)	1.78975963
91	Albinism (HP:0001022)	1.78006919
92	Macular degeneration (HP:0000608)	1.74607916
93	Tubulointerstitial abnormality (HP:0001969)	1.73991790
94	Progressive inability to walk (HP:0002505)	1.73966978
95	Astigmatism (HP:0000483)	1.73807655
96	Lissencephaly (HP:0001339)	1.73474309
97	Renal Fanconi syndrome (HP:0001994)	1.71884428
98	Patellar aplasia (HP:0006443)	1.71608669
99	Chorioretinal atrophy (HP:0000533)	1.71507212
100	Abnormality of glycine metabolism (HP:0010895)	1.70689705

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.60217472
2	FRK	3.59373786
3	NUAK1	3.51182861
4	VRK2	2.83243345
5	PINK1	2.67318786
6	BMPR1B	2.65612625
7	ZAK	2.46479719
8	ACVR1B	2.30060529
9	TNIK	2.18855832
10	ADRBK2	2.12983590
11	STK16	1.65728734
12	CDC7	1.63704233
13	PTK2B	1.61327933
14	STK39	1.58838902
15	WNK3	1.52463130
16	BCKDK	1.51356304
17	MUSK	1.51031212
18	VRK1	1.49391650
19	WNK4	1.47993043
20	EIF2AK3	1.47972550
21	INSRR	1.43521136
22	CSNK1G3	1.35913058
23	IKBKB	1.32913325
24	GRK1	1.30832646
25	CSNK1G1	1.27392712
26	MAPK13	1.26963885
27	TAOK3	1.23790323
28	BRSK2	1.23540183
29	CASK	1.22228101
30	EIF2AK1	1.22106993
31	TRIM28	1.20340679
32	PIM2	1.17766583
33	CSNK1G2	1.15113377
34	WEE1	1.13724250
35	DAPK2	1.13091747
36	PBK	1.11682270
37	PLK3	1.11113149
38	PNCK	1.08656172
39	CSNK1A1L	1.07944004
40	DYRK2	1.07135807
41	MKNK2	1.06914575
42	MKNK1	0.99006757
43	TLK1	0.98994770
44	MARK1	0.98182069
45	TAF1	0.95083855
46	PAK3	0.93342480
47	CCNB1	0.92142067
48	ATR	0.90053479
49	NTRK3	0.90047116
50	OXSR1	0.84802546
51	BCR	0.84592046
52	MST4	0.83207977
53	MAPKAPK5	0.80043914
54	PLK1	0.77307900
55	PLK2	0.76749358
56	CHEK2	0.76125136
57	CAMKK2	0.75660704
58	NME2	0.75249123
59	BUB1	0.75117173
60	TNK2	0.74815603
61	DAPK1	0.74797088
62	MAPKAPK3	0.74506044
63	PRKCE	0.72677214
64	CSNK1A1	0.72311474
65	PRKCG	0.71770702
66	TEC	0.67188199
67	PRKCI	0.62891321
68	MAP3K4	0.61804743
69	MAP2K2	0.60180059
70	PRKD2	0.59457017
71	PKN1	0.58604935
72	AKT3	0.56633594
73	ATM	0.56334268
74	ADRBK1	0.55582744
75	NME1	0.55468285
76	RPS6KA5	0.53484555
77	FLT3	0.53191016
78	ICK	0.52134550
79	GRK5	0.51820763
80	MAP2K6	0.51039137
81	PHKG2	0.48505644
82	PHKG1	0.48505644
83	DYRK1A	0.47347177
84	CSNK1D	0.46258321
85	MAP3K11	0.43213461
86	MAPK11	0.42012258
87	TGFBR1	0.41735628
88	ABL1	0.40739144
89	PLK4	0.38941304
90	CAMK1G	0.38375258
91	ABL2	0.37266233
92	DYRK3	0.36526074
93	STK3	0.35996614
94	KDR	0.34872525
95	CSNK2A1	0.34526653
96	PRKCQ	0.34017725
97	MINK1	0.33723117
98	MAP2K1	0.33152729
99	DAPK3	0.31189353
100	PRKDC	0.30658843

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.77676830
2	Fanconi anemia pathway_Homo sapiens_hsa03460	2.72953897
3	Phototransduction_Homo sapiens_hsa04744	2.60082664
4	Homologous recombination_Homo sapiens_hsa03440	2.53125333
5	Protein export_Homo sapiens_hsa03060	2.41481430
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.33769092
7	Butanoate metabolism_Homo sapiens_hsa00650	2.28058356
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.27601590
9	RNA polymerase_Homo sapiens_hsa03020	2.07170245
10	Oxidative phosphorylation_Homo sapiens_hsa00190	1.99376782
11	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.96371955
12	Base excision repair_Homo sapiens_hsa03410	1.88268877
13	Proteasome_Homo sapiens_hsa03050	1.87340305
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.83415444
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.81156348
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.79605972
17	Fatty acid elongation_Homo sapiens_hsa00062	1.75595241
18	One carbon pool by folate_Homo sapiens_hsa00670	1.72277011
19	Propanoate metabolism_Homo sapiens_hsa00640	1.69616581
20	Basal transcription factors_Homo sapiens_hsa03022	1.68830957
21	Parkinsons disease_Homo sapiens_hsa05012	1.67497419
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.65594799
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.50426192
24	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.49686918
25	Mismatch repair_Homo sapiens_hsa03430	1.45177142
26	Olfactory transduction_Homo sapiens_hsa04740	1.45098923
27	Non-homologous end-joining_Homo sapiens_hsa03450	1.40056161
28	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.37893532
29	Pyrimidine metabolism_Homo sapiens_hsa00240	1.36686307
30	Linoleic acid metabolism_Homo sapiens_hsa00591	1.36607161
31	Peroxisome_Homo sapiens_hsa04146	1.36367952
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.33998419
33	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.32626499
34	Tryptophan metabolism_Homo sapiens_hsa00380	1.30247394
35	Nucleotide excision repair_Homo sapiens_hsa03420	1.30098412
36	RNA degradation_Homo sapiens_hsa03018	1.29925469
37	DNA replication_Homo sapiens_hsa03030	1.26795445
38	Ether lipid metabolism_Homo sapiens_hsa00565	1.26333608
39	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.20777083
40	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.18251088
41	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.17537946
42	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.17059139
43	Nicotine addiction_Homo sapiens_hsa05033	1.13673251
44	Purine metabolism_Homo sapiens_hsa00230	1.11040268
45	RNA transport_Homo sapiens_hsa03013	1.10253593
46	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.05912751
47	Asthma_Homo sapiens_hsa05310	1.05260742
48	Huntingtons disease_Homo sapiens_hsa05016	1.03803249
49	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.03401731
50	Collecting duct acid secretion_Homo sapiens_hsa04966	1.03220056
51	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.93696568
52	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.93436828
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.90488812
54	Taste transduction_Homo sapiens_hsa04742	0.89093915
55	Caffeine metabolism_Homo sapiens_hsa00232	0.88144970
56	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.87489389
57	Metabolic pathways_Homo sapiens_hsa01100	0.85661510
58	Glutathione metabolism_Homo sapiens_hsa00480	0.85190419
59	beta-Alanine metabolism_Homo sapiens_hsa00410	0.82209928
60	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.80116772
61	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.78950283
62	Regulation of autophagy_Homo sapiens_hsa04140	0.77724530
63	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.77668938
64	Chemical carcinogenesis_Homo sapiens_hsa05204	0.77459178
65	Fatty acid metabolism_Homo sapiens_hsa01212	0.77364800
66	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.76786546
67	Sulfur metabolism_Homo sapiens_hsa00920	0.76769060
68	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.76100477
69	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.75461141
70	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.75434557
71	Alzheimers disease_Homo sapiens_hsa05010	0.72532419
72	Sulfur relay system_Homo sapiens_hsa04122	0.71956106
73	Glycerolipid metabolism_Homo sapiens_hsa00561	0.69958014
74	Steroid biosynthesis_Homo sapiens_hsa00100	0.67426326
75	Other glycan degradation_Homo sapiens_hsa00511	0.66917293
76	Spliceosome_Homo sapiens_hsa03040	0.65855994
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.59008884
78	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.58669811
79	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.57568239
80	Rheumatoid arthritis_Homo sapiens_hsa05323	0.57475243
81	Morphine addiction_Homo sapiens_hsa05032	0.56512833
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.55728967
83	GABAergic synapse_Homo sapiens_hsa04727	0.55516883
84	ABC transporters_Homo sapiens_hsa02010	0.53722482
85	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.52177819
86	Sphingolipid metabolism_Homo sapiens_hsa00600	0.51466539
87	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.50582596
88	Salivary secretion_Homo sapiens_hsa04970	0.50260898
89	Circadian entrainment_Homo sapiens_hsa04713	0.50010277
90	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.49377184
91	p53 signaling pathway_Homo sapiens_hsa04115	0.49196722
92	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.47754913
93	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.47511292
94	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.43875628
95	Lysine degradation_Homo sapiens_hsa00310	0.43143773
96	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.42825224
97	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.42261388
98	Insulin secretion_Homo sapiens_hsa04911	0.41167116
99	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.40901995
100	Serotonergic synapse_Homo sapiens_hsa04726	0.40068928

PRELID3A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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