ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	lactate metabolic process (GO:0006089)	4.96927311
2	proteasome assembly (GO:0043248)	4.74167207
3	keratinocyte development (GO:0003334)	4.61192511
4	pteridine-containing compound biosynthetic process (GO:0042559)	4.14807046
5	ribosome assembly (GO:0042255)	3.88594766
6	positive regulation of protein autophosphorylation (GO:0031954)	3.79369062
7	folic acid-containing compound biosynthetic process (GO:0009396)	3.75153197
8	cellular ketone body metabolic process (GO:0046950)	3.69837610
9	signal peptide processing (GO:0006465)	3.69515954
10	regulation of glucokinase activity (GO:0033131)	3.63323923
11	regulation of hexokinase activity (GO:1903299)	3.63323923
12	respiratory chain complex IV assembly (GO:0008535)	3.61185663
13	ketone body metabolic process (GO:1902224)	3.56870952
14	water-soluble vitamin biosynthetic process (GO:0042364)	3.53304696
15	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.41430201
16	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.41430201
17	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.41430201
18	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.34892381
19	regulation of type B pancreatic cell apoptotic process (GO:2000674)	3.33234096
20	regulation of cellular amino acid metabolic process (GO:0006521)	3.32723566
21	positive regulation of glycolytic process (GO:0045821)	3.32269090
22	intestinal epithelial cell development (GO:0060576)	3.24195146
23	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.22061001
24	rRNA methylation (GO:0031167)	3.20135281
25	inositol phosphate catabolic process (GO:0071545)	3.17345711
26	protein K6-linked ubiquitination (GO:0085020)	3.14897823
27	rRNA modification (GO:0000154)	3.14331002
28	zinc ion transport (GO:0006829)	3.14098575
29	negative regulation of execution phase of apoptosis (GO:1900118)	3.08843478
30	cytochrome complex assembly (GO:0017004)	3.08812377
31	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.06265596
32	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.04961394
33	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.04961394
34	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.04878170
35	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.04878170
36	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.04878170
37	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.03277060
38	inositol phosphate dephosphorylation (GO:0046855)	3.01023174
39	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.01023174
40	desmosome organization (GO:0002934)	2.97915657
41	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.97315846
42	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.97315846
43	ER overload response (GO:0006983)	2.93021706
44	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.92404049
45	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.92095263
46	cullin deneddylation (GO:0010388)	2.91860113
47	polyol catabolic process (GO:0046174)	2.91683525
48	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.90611039
49	positive regulation of actin filament depolymerization (GO:0030836)	2.88634736
50	mitotic sister chromatid cohesion (GO:0007064)	2.87046641
51	positive regulation of ligase activity (GO:0051351)	2.83068692
52	regulation of centriole replication (GO:0046599)	2.81122587
53	negative regulation of neurological system process (GO:0031645)	2.79685964
54	negative regulation of acute inflammatory response (GO:0002674)	2.78934907
55	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.78541825
56	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.78541825
57	isotype switching (GO:0045190)	2.78541825
58	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.76324317
59	pteridine-containing compound metabolic process (GO:0042558)	2.75843633
60	endocrine pancreas development (GO:0031018)	2.74223158
61	negative regulation of ligase activity (GO:0051352)	2.74136869
62	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.74136869
63	regulation of mitochondrial translation (GO:0070129)	2.71474533
64	COPII vesicle coating (GO:0048208)	2.70364007
65	prenylation (GO:0097354)	2.70131152
66	protein prenylation (GO:0018342)	2.70131152
67	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.68479135
68	maturation of 5.8S rRNA (GO:0000460)	2.68155220
69	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.67249228
70	branched-chain amino acid catabolic process (GO:0009083)	2.63815924
71	protein deneddylation (GO:0000338)	2.63594920
72	positive regulation of histone H3-K4 methylation (GO:0051571)	2.63309750
73	magnesium ion transport (GO:0015693)	2.62230193
74	zinc ion transmembrane transport (GO:0071577)	2.61628266
75	positive regulation of glycoprotein biosynthetic process (GO:0010560)	2.57589952
76	tetrahydrofolate metabolic process (GO:0046653)	2.57212125
77	positive regulation of chromosome segregation (GO:0051984)	2.57128479
78	non-recombinational repair (GO:0000726)	2.55709687
79	double-strand break repair via nonhomologous end joining (GO:0006303)	2.55709687
80	regulation of ubiquitin-protein transferase activity (GO:0051438)	2.48379208
81	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.47255129
82	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	2.46695580
83	replication fork processing (GO:0031297)	2.45647847
84	synapsis (GO:0007129)	2.45191905
85	pseudouridine synthesis (GO:0001522)	2.44955267
86	regulation of B cell apoptotic process (GO:0002902)	2.44181474
87	regulation of ligase activity (GO:0051340)	2.43938139
88	mitochondrial RNA metabolic process (GO:0000959)	2.42644745
89	regulation of Rac protein signal transduction (GO:0035020)	2.42590259
90	fatty acid homeostasis (GO:0055089)	2.39911868
91	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.39805298
92	mitochondrial DNA replication (GO:0006264)	2.39223033
93	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.39102214
94	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.39102214
95	inositol phosphate-mediated signaling (GO:0048016)	2.38753794
96	positive regulation of cell cycle arrest (GO:0071158)	2.38030210
97	transcription from mitochondrial promoter (GO:0006390)	2.37501973
98	peptidyl-histidine modification (GO:0018202)	2.37081721
99	folic acid-containing compound metabolic process (GO:0006760)	2.35971802
100	DNA deamination (GO:0045006)	2.35141567

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.46074059
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.35029379
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.34038290
4	E2F7_22180533_ChIP-Seq_HELA_Human	3.27251942
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.86247982
6	ELK1_19687146_ChIP-ChIP_HELA_Human	2.79619275
7	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.59042996
8	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.47346172
9	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.33331135
10	PADI4_21655091_ChIP-ChIP_MCF-7_Human	2.27333436
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.18138570
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.16251810
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.09224221
14	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.04186485
15	AR_21909140_ChIP-Seq_LNCAP_Human	2.02714688
16	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.00951717
17	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.99677415
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.99492397
19	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.98265043
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.97846028
21	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.96932305
22	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.95633762
23	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.94713264
24	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.93269305
25	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.84376985
26	DCP1A_22483619_ChIP-Seq_HELA_Human	1.82731101
27	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.75325419
28	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.73927737
29	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.72612109
30	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.69659298
31	FOXP3_21729870_ChIP-Seq_TREG_Human	1.69260908
32	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.69149636
33	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.64763808
34	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.53362409
35	TFEB_21752829_ChIP-Seq_HELA_Human	1.53242712
36	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.52159633
37	EWS_26573619_Chip-Seq_HEK293_Human	1.45447291
38	FUS_26573619_Chip-Seq_HEK293_Human	1.44800124
39	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.44206753
40	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.42252853
41	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.41632986
42	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.41114550
43	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.37487538
44	KDM5A_27292631_Chip-Seq_BREAST_Human	1.33575716
45	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	1.32572627
46	ER_23166858_ChIP-Seq_MCF-7_Human	1.32071108
47	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.31006698
48	VDR_22108803_ChIP-Seq_LS180_Human	1.29051305
49	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.28496534
50	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.27571510
51	MYC_18940864_ChIP-ChIP_HL60_Human	1.23955765
52	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.22758155
53	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.22300936
54	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.22254341
55	GABP_19822575_ChIP-Seq_HepG2_Human	1.21070176
56	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.19850386
57	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.18235263
58	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.16737397
59	ELF5_23300383_ChIP-Seq_T47D_Human	1.15661395
60	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.13640920
61	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	1.13047504
62	CDX2_22108803_ChIP-Seq_LS180_Human	1.07961320
63	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.07806172
64	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.07181575
65	ZNF274_21170338_ChIP-Seq_K562_Hela	1.04916281
66	HTT_18923047_ChIP-ChIP_STHdh_Human	1.04750321
67	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.04511682
68	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.04345417
69	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.02869239
70	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.00882685
71	TTF2_22483619_ChIP-Seq_HELA_Human	1.00570667
72	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.99937402
73	TP53_22573176_ChIP-Seq_HFKS_Human	0.97483660
74	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.96838113
75	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.96523628
76	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.95697121
77	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.95205601
78	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.94618367
79	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.94445755
80	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.93828528
81	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.93226976
82	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.93006476
83	SOX2_20726797_ChIP-Seq_SW620_Human	0.91416946
84	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.89608164
85	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.89506907
86	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.89420375
87	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.89420375
88	GATA4_25053715_ChIP-Seq_YYC3_Human	0.89101032
89	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.89082399
90	P300_19829295_ChIP-Seq_ESCs_Human	0.89077130
91	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.87779013
92	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.87366054
93	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.86903172
94	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.86354977
95	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.86243431
96	P300_18555785_Chip-Seq_ESCs_Mouse	0.85925068
97	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.85780667
98	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.85285988
99	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.84936282
100	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.84790189

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010234_abnormal_vibrissa_follicle	6.15555799
2	MP0002837_dystrophic_cardiac_calcinosis	3.38053696
3	MP0008057_abnormal_DNA_replication	3.23018081
4	MP0005379_endocrine/exocrine_gland_phen	3.02828504
5	MP0009780_abnormal_chondrocyte_physiolo	2.78275579
6	MP0002163_abnormal_gland_morphology	2.66074933
7	MP0010352_gastrointestinal_tract_polyps	2.50147601
8	MP0003195_calcinosis	2.43878872
9	MP0003806_abnormal_nucleotide_metabolis	2.41007950
10	MP0002166_altered_tumor_susceptibility	2.38673000
11	MP0000372_irregular_coat_pigmentation	2.35508793
12	MP0010678_abnormal_skin_adnexa	2.24090051
13	MP0008058_abnormal_DNA_repair	2.22484575
14	MP0003786_premature_aging	2.22341784
15	MP0010094_abnormal_chromosome_stability	2.18027648
16	MP0001944_abnormal_pancreas_morphology	1.98236191
17	MP0005408_hypopigmentation	1.95476052
18	MP0002693_abnormal_pancreas_physiology	1.95337526
19	MP0000427_abnormal_hair_cycle	1.93040097
20	MP0001661_extended_life_span	1.92865334
21	MP0002909_abnormal_adrenal_gland	1.91918379
22	MP0000013_abnormal_adipose_tissue	1.86592446
23	MP0003693_abnormal_embryo_hatching	1.86031727
24	MP0009697_abnormal_copulation	1.84136731
25	MP0002006_tumorigenesis	1.80671706
26	MP0005075_abnormal_melanosome_morpholog	1.76324456
27	MP0002009_preneoplasia	1.73811999
28	MP0004957_abnormal_blastocyst_morpholog	1.73223741
29	MP0006072_abnormal_retinal_apoptosis	1.70909427
30	MP0006036_abnormal_mitochondrial_physio	1.70688168
31	MP0002938_white_spotting	1.66795925
32	MP0005220_abnormal_exocrine_pancreas	1.64431432
33	MP0002877_abnormal_melanocyte_morpholog	1.62567630
34	MP0005332_abnormal_amino_acid	1.61422601
35	MP0003787_abnormal_imprinting	1.55390118
36	MP0010307_abnormal_tumor_latency	1.51841852
37	MP0005646_abnormal_pituitary_gland	1.48655265
38	MP0005367_renal/urinary_system_phenotyp	1.43861508
39	MP0000516_abnormal_urinary_system	1.43861508
40	MP0002160_abnormal_reproductive_system	1.43530329
41	MP0005645_abnormal_hypothalamus_physiol	1.38214374
42	MP0003186_abnormal_redox_activity	1.38089076
43	MP0008877_abnormal_DNA_methylation	1.35417501
44	MP0008007_abnormal_cellular_replicative	1.33501209
45	MP0002090_abnormal_vision	1.31232497
46	MP0003111_abnormal_nucleus_morphology	1.30313904
47	MP0000647_abnormal_sebaceous_gland	1.29160277
48	MP0002876_abnormal_thyroid_physiology	1.29155287
49	MP0001764_abnormal_homeostasis	1.28604111
50	MP0003718_maternal_effect	1.25713063
51	MP0004147_increased_porphyrin_level	1.24543093
52	MP0002102_abnormal_ear_morphology	1.22780687
53	MP0005389_reproductive_system_phenotype	1.20758399
54	MP0001919_abnormal_reproductive_system	1.18085963
55	MP0005636_abnormal_mineral_homeostasis	1.14440778
56	MP0000613_abnormal_salivary_gland	1.14227347
57	MP0003077_abnormal_cell_cycle	1.12429569
58	MP0000015_abnormal_ear_pigmentation	1.09927526
59	MP0001756_abnormal_urination	1.08818724
60	MP0003950_abnormal_plasma_membrane	1.05412416
61	MP0002139_abnormal_hepatobiliary_system	1.04168842
62	MP0002638_abnormal_pupillary_reflex	1.02706131
63	MP0000003_abnormal_adipose_tissue	1.02427713
64	MP0002078_abnormal_glucose_homeostasis	1.02061504
65	MP0000383_abnormal_hair_follicle	1.00978978
66	MP0000377_abnormal_hair_follicle	1.00174106
67	MP0006035_abnormal_mitochondrial_morpho	0.91910957
68	MP0005174_abnormal_tail_pigmentation	0.89283860
69	MP0003123_paternal_imprinting	0.88607457
70	MP0009643_abnormal_urine_homeostasis	0.88436900
71	MP0004019_abnormal_vitamin_homeostasis	0.87015244
72	MP0004264_abnormal_extraembryonic_tissu	0.86807443
73	MP0002396_abnormal_hematopoietic_system	0.86502844
74	MP0005253_abnormal_eye_physiology	0.85793782
75	MP0000358_abnormal_cell_content/	0.85700364
76	MP0000371_diluted_coat_color	0.85363333
77	MP0008872_abnormal_physiological_respon	0.85271265
78	MP0001216_abnormal_epidermal_layer	0.84058438
79	MP0008875_abnormal_xenobiotic_pharmacok	0.83640309
80	MP0005084_abnormal_gallbladder_morpholo	0.83609891
81	MP0006054_spinal_hemorrhage	0.81053139
82	MP0000538_abnormal_urinary_bladder	0.79863505
83	MP0005187_abnormal_penis_morphology	0.79504191
84	MP0000569_abnormal_digit_pigmentation	0.76965643
85	MP0001929_abnormal_gametogenesis	0.76512685
86	MP0001881_abnormal_mammary_gland	0.75772525
87	MP0005248_abnormal_Harderian_gland	0.74359964
88	MP0008995_early_reproductive_senescence	0.74359849
89	MP0002060_abnormal_skin_morphology	0.73887953
90	MP0008775_abnormal_heart_ventricle	0.72759980
91	MP0001727_abnormal_embryo_implantation	0.72328782
92	MP0003953_abnormal_hormone_level	0.72142901
93	MP0003943_abnormal_hepatobiliary_system	0.72036649
94	MP0004381_abnormal_hair_follicle	0.71792660
95	MP0000627_abnormal_mammary_gland	0.70756719
96	MP0005395_other_phenotype	0.70008794
97	MP0001765_abnormal_ion_homeostasis	0.69947973
98	MP0010329_abnormal_lipoprotein_level	0.68081331
99	MP0008932_abnormal_embryonic_tissue	0.67005828
100	MP0005365_abnormal_bile_salt	0.66150470

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoglycemic coma (HP:0001325)	4.66905304
2	Hyperinsulinemic hypoglycemia (HP:0000825)	4.44010349
3	Hypoglycemic seizures (HP:0002173)	4.40827375
4	Ketoacidosis (HP:0001993)	3.92817034
5	Hyperglycemia (HP:0003074)	3.83576642
6	Symptomatic seizures (HP:0011145)	3.59846567
7	Cutaneous melanoma (HP:0012056)	3.33610973
8	Hypothermia (HP:0002045)	3.31500181
9	Progressive macrocephaly (HP:0004481)	3.15799958
10	Tongue fasciculations (HP:0001308)	3.03820132
11	Conjunctival hamartoma (HP:0100780)	3.01961502
12	Large for gestational age (HP:0001520)	3.01210079
13	Abnormality of the pancreatic islet cells (HP:0006476)	2.96031678
14	Abnormality of endocrine pancreas physiology (HP:0012093)	2.96031678
15	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.84644124
16	Neoplasm of the adrenal cortex (HP:0100641)	2.82149128
17	Acute necrotizing encephalopathy (HP:0006965)	2.81905051
18	Abnormality of vitamin B metabolism (HP:0004340)	2.80368021
19	Hamartoma of the eye (HP:0010568)	2.80078831
20	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.77259689
21	Hypoplasia of the fovea (HP:0007750)	2.77259689
22	Hypokinesia (HP:0002375)	2.76772244
23	Insulin-resistant diabetes mellitus (HP:0000831)	2.66519672
24	Abnormality of methionine metabolism (HP:0010901)	2.66230941
25	Enlarged penis (HP:0000040)	2.64545579
26	Patchy hypopigmentation of hair (HP:0011365)	2.62137138
27	Increased CSF lactate (HP:0002490)	2.60905286
28	Cerebral edema (HP:0002181)	2.58195916
29	Acute encephalopathy (HP:0006846)	2.57112838
30	Hypomagnesemia (HP:0002917)	2.55512756
31	Abnormal mitochondria in muscle tissue (HP:0008316)	2.49589922
32	Neoplasm of the adrenal gland (HP:0100631)	2.48135054
33	Hepatic necrosis (HP:0002605)	2.47979903
34	Ketosis (HP:0001946)	2.46713581
35	Pancreatic islet-cell hyperplasia (HP:0004510)	2.46225738
36	Methylmalonic acidemia (HP:0002912)	2.44777676
37	Renal cortical cysts (HP:0000803)	2.39307440
38	Breast carcinoma (HP:0003002)	2.37721734
39	Chromsome breakage (HP:0040012)	2.36017443
40	Mitochondrial inheritance (HP:0001427)	2.33948647
41	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.33647627
42	Muscle fibrillation (HP:0010546)	2.33159551
43	Prominent metopic ridge (HP:0005487)	2.32362416
44	Increased hepatocellular lipid droplets (HP:0006565)	2.25646157
45	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.23019370
46	Hypobetalipoproteinemia (HP:0003563)	2.19557325
47	White forelock (HP:0002211)	2.18055586
48	Asymmetry of the thorax (HP:0001555)	2.15708106
49	Abnormality of the preputium (HP:0100587)	2.14790437
50	Abnormality of the fovea (HP:0000493)	2.14615538
51	Sensory axonal neuropathy (HP:0003390)	2.14039505
52	Meningioma (HP:0002858)	2.06363407
53	Abnormality of vitamin metabolism (HP:0100508)	2.04682660
54	Septate vagina (HP:0001153)	2.04565131
55	Abnormality of the renal cortex (HP:0011035)	2.03770086
56	Abnormality of chromosome stability (HP:0003220)	2.03466118
57	Vascular calcification (HP:0004934)	2.03367553
58	Aplasia/hypoplasia of the uterus (HP:0008684)	2.03160690
59	Adrenal hypoplasia (HP:0000835)	2.01409347
60	Abnormality of magnesium homeostasis (HP:0004921)	2.01075604
61	Lipid accumulation in hepatocytes (HP:0006561)	2.00406432
62	Lethargy (HP:0001254)	2.00216080
63	Muscular hypotonia of the trunk (HP:0008936)	2.00166649
64	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.98651315
65	Increased serum lactate (HP:0002151)	1.96937450
66	Megaloblastic anemia (HP:0001889)	1.96566784
67	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.95611380
68	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.95611380
69	Double outlet right ventricle (HP:0001719)	1.95438443
70	Congenital malformation of the right heart (HP:0011723)	1.95438443
71	Abnormality of urine glucose concentration (HP:0011016)	1.93515453
72	Glycosuria (HP:0003076)	1.93515453
73	Methylmalonic aciduria (HP:0012120)	1.93194464
74	Respiratory failure (HP:0002878)	1.93121440
75	Volvulus (HP:0002580)	1.92801997
76	Abnormality of glycolysis (HP:0004366)	1.92010679
77	Thyroiditis (HP:0100646)	1.89934547
78	Proximal tubulopathy (HP:0000114)	1.88695116
79	Degeneration of anterior horn cells (HP:0002398)	1.88687996
80	Abnormality of the anterior horn cell (HP:0006802)	1.88687996
81	Type I transferrin isoform profile (HP:0003642)	1.87385577
82	Intestinal atresia (HP:0011100)	1.86553035
83	Abnormality of the metopic suture (HP:0005556)	1.86112940
84	Albinism (HP:0001022)	1.84637867
85	Hepatocellular necrosis (HP:0001404)	1.84189083
86	Neuroendocrine neoplasm (HP:0100634)	1.83451698
87	Lactic acidosis (HP:0003128)	1.83136506
88	Unilateral renal agenesis (HP:0000122)	1.83017971
89	Aqueductal stenosis (HP:0002410)	1.81400181
90	Palpitations (HP:0001962)	1.80980550
91	Testicular neoplasm (HP:0010788)	1.79061208
92	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	1.78777469
93	Sparse eyelashes (HP:0000653)	1.78531177
94	Urethral obstruction (HP:0000796)	1.77558474
95	Orthostatic hypotension (HP:0001278)	1.77049065
96	Late onset (HP:0003584)	1.76248276
97	Thyroid carcinoma (HP:0002890)	1.75568299
98	Ependymoma (HP:0002888)	1.74864643
99	Abnormality of the astrocytes (HP:0100707)	1.74739257
100	Astrocytoma (HP:0009592)	1.74739257

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST4	5.42578626
2	FRK	5.40343242
3	EIF2AK3	4.01191559
4	EIF2AK1	3.53888490
5	TRIM28	2.38468790
6	ERBB3	2.25441387
7	BRSK2	2.14452029
8	BUB1	2.13850602
9	STK39	2.04735088
10	MAP3K12	2.01797289
11	FGFR2	1.96665101
12	MST1R	1.93049558
13	WEE1	1.90695687
14	ACVR1B	1.87790279
15	TSSK6	1.85829436
16	PLK3	1.74361384
17	STK3	1.70434159
18	MKNK2	1.65438139
19	SCYL2	1.60883058
20	PDK2	1.58860870
21	NEK1	1.55800983
22	FER	1.53069003
23	STK24	1.37805691
24	PBK	1.36049210
25	EPHA2	1.35127162
26	GRK1	1.28805477
27	OXSR1	1.27762218
28	ZAK	1.24499937
29	SIK3	1.23074618
30	STK16	1.22497091
31	SRPK1	1.20538879
32	NUAK1	1.20349453
33	MAP4K2	1.19661512
34	PLK2	1.15943519
35	BMPR1B	1.13449329
36	PHKG2	1.11665624
37	PHKG1	1.11665624
38	EIF2AK2	1.09567216
39	TTK	1.05553289
40	PRKCI	1.05214999
41	RPS6KB2	1.05008008
42	MKNK1	1.04289778
43	PAK3	1.01966343
44	STK10	1.00282425
45	STK38L	0.97690721
46	TRPM7	0.96131184
47	BMPR2	0.95880621
48	BRSK1	0.95379496
49	INSRR	0.92977233
50	CSNK1G1	0.91362058
51	PASK	0.90460075
52	MAP3K2	0.89784071
53	BCR	0.89762115
54	NME2	0.89181843
55	VRK2	0.86216234
56	PLK1	0.82338954
57	CSNK1G3	0.79928474
58	FGFR3	0.73577713
59	WNK3	0.69701697
60	PLK4	0.69237637
61	STK4	0.68645486
62	MAPKAPK3	0.68546234
63	MET	0.68539406
64	CCNB1	0.66806793
65	PAK4	0.64984378
66	VRK1	0.64730300
67	MUSK	0.64253769
68	PRKCE	0.62514103
69	IRAK3	0.56872903
70	CAMK2D	0.54615147
71	TAF1	0.52943762
72	NEK6	0.52071186
73	LIMK1	0.51956364
74	YES1	0.51595127
75	CSNK1G2	0.49113040
76	ATM	0.46018180
77	CSNK1A1L	0.42440091
78	ADRBK2	0.42287029
79	AKT3	0.41921381
80	ILK	0.40150109
81	WNK4	0.40103024
82	CDC7	0.37593916
83	AURKB	0.37473979
84	MAP2K1	0.37367450
85	MAPKAPK5	0.34191021
86	AKT2	0.34002241
87	ERBB4	0.33914298
88	NLK	0.32858113
89	CHEK2	0.31247431
90	IKBKB	0.30406180
91	PRKAA2	0.29678077
92	TLK1	0.29581622
93	DAPK1	0.28561648
94	TESK1	0.28155791
95	CSNK2A2	0.27590017
96	CAMKK2	0.26423024
97	MYLK	0.25853694
98	ATR	0.25146858
99	CSNK2A1	0.24348388
100	CHEK1	0.23743877

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	4.17197519
2	Proteasome_Homo sapiens_hsa03050	4.07394136
3	Protein export_Homo sapiens_hsa03060	4.06715835
4	Vitamin B6 metabolism_Homo sapiens_hsa00750	3.24526343
5	Sulfur metabolism_Homo sapiens_hsa00920	2.70125056
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.57632164
7	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.33800589
8	Non-homologous end-joining_Homo sapiens_hsa03450	2.25983314
9	Folate biosynthesis_Homo sapiens_hsa00790	2.21125826
10	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.11893012
11	Propanoate metabolism_Homo sapiens_hsa00640	2.05301258
12	Butanoate metabolism_Homo sapiens_hsa00650	2.04588396
13	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.96765804
14	Oxidative phosphorylation_Homo sapiens_hsa00190	1.96712207
15	Homologous recombination_Homo sapiens_hsa03440	1.86062228
16	One carbon pool by folate_Homo sapiens_hsa00670	1.85273164
17	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.84597093
18	Fatty acid elongation_Homo sapiens_hsa00062	1.83942705
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.71377803
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.67207553
21	Mismatch repair_Homo sapiens_hsa03430	1.63973888
22	RNA polymerase_Homo sapiens_hsa03020	1.57812549
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.54334319
24	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.52241999
25	Collecting duct acid secretion_Homo sapiens_hsa04966	1.48486423
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.48440020
27	Basal transcription factors_Homo sapiens_hsa03022	1.45118808
28	RNA degradation_Homo sapiens_hsa03018	1.42892339
29	RNA transport_Homo sapiens_hsa03013	1.41869194
30	Nucleotide excision repair_Homo sapiens_hsa03420	1.27154752
31	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.24690380
32	Parkinsons disease_Homo sapiens_hsa05012	1.21866417
33	DNA replication_Homo sapiens_hsa03030	1.19985097
34	Peroxisome_Homo sapiens_hsa04146	1.16793703
35	Tryptophan metabolism_Homo sapiens_hsa00380	1.16464471
36	Pyrimidine metabolism_Homo sapiens_hsa00240	1.12152548
37	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.09482821
38	Vibrio cholerae infection_Homo sapiens_hsa05110	1.07164091
39	Circadian rhythm_Homo sapiens_hsa04710	1.06775614
40	Nitrogen metabolism_Homo sapiens_hsa00910	1.05329840
41	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.02827487
42	Sphingolipid metabolism_Homo sapiens_hsa00600	1.02438672
43	Glutathione metabolism_Homo sapiens_hsa00480	1.00908996
44	Mineral absorption_Homo sapiens_hsa04978	1.00134458
45	Regulation of autophagy_Homo sapiens_hsa04140	0.98318039
46	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.96376703
47	Fatty acid metabolism_Homo sapiens_hsa01212	0.94846729
48	Purine metabolism_Homo sapiens_hsa00230	0.93432796
49	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.93004944
50	Pyruvate metabolism_Homo sapiens_hsa00620	0.92919316
51	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.92587390
52	Arginine biosynthesis_Homo sapiens_hsa00220	0.91671085
53	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.91021797
54	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.89889511
55	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.89225529
56	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.88566691
57	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.82849041
58	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.79014103
59	Caffeine metabolism_Homo sapiens_hsa00232	0.78957283
60	Alzheimers disease_Homo sapiens_hsa05010	0.78501029
61	Cell cycle_Homo sapiens_hsa04110	0.77015092
62	Metabolic pathways_Homo sapiens_hsa01100	0.75519685
63	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.72548569
64	Oocyte meiosis_Homo sapiens_hsa04114	0.71511941
65	Huntingtons disease_Homo sapiens_hsa05016	0.70404808
66	Insulin secretion_Homo sapiens_hsa04911	0.69321443
67	p53 signaling pathway_Homo sapiens_hsa04115	0.68233487
68	Fatty acid degradation_Homo sapiens_hsa00071	0.63054321
69	Carbon metabolism_Homo sapiens_hsa01200	0.62415311
70	Spliceosome_Homo sapiens_hsa03040	0.62282327
71	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.59069799
72	Type I diabetes mellitus_Homo sapiens_hsa04940	0.57849893
73	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.57311672
74	Steroid biosynthesis_Homo sapiens_hsa00100	0.54883915
75	Base excision repair_Homo sapiens_hsa03410	0.46361936
76	beta-Alanine metabolism_Homo sapiens_hsa00410	0.45338340
77	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.44191688
78	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.41500203
79	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.40645031
80	Ether lipid metabolism_Homo sapiens_hsa00565	0.40106374
81	Legionellosis_Homo sapiens_hsa05134	0.38443326
82	Pentose phosphate pathway_Homo sapiens_hsa00030	0.35113394
83	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.34503003
84	Retinol metabolism_Homo sapiens_hsa00830	0.34404219
85	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.34101108
86	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.33373729
87	Phototransduction_Homo sapiens_hsa04744	0.33306588
88	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.31498610
89	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.31213633
90	Chemical carcinogenesis_Homo sapiens_hsa05204	0.30594830
91	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.30566810
92	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.30520555
93	Glucagon signaling pathway_Homo sapiens_hsa04922	0.30192262
94	mRNA surveillance pathway_Homo sapiens_hsa03015	0.27516163
95	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.25862851
96	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.24563689
97	mTOR signaling pathway_Homo sapiens_hsa04150	0.23117500
98	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.22343671
99	ABC transporters_Homo sapiens_hsa02010	0.21864415
100	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.21173028

PRELID3B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »