PREP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytosolic prolyl endopeptidase that cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Prolyl endopeptidases have been reported to be involved in the maturation and degradation of peptide hormones and neuropeptides. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.33981697
2protein localization to kinetochore (GO:0034501)4.74521192
3DNA strand elongation involved in DNA replication (GO:0006271)4.62272789
4hemidesmosome assembly (GO:0031581)4.46648336
5DNA strand elongation (GO:0022616)4.37692644
6COPI coating of Golgi vesicle (GO:0048205)4.35107877
7Golgi transport vesicle coating (GO:0048200)4.35107877
8folic acid-containing compound biosynthetic process (GO:0009396)4.30677062
9formation of translation preinitiation complex (GO:0001731)4.20732543
10mitotic nuclear envelope disassembly (GO:0007077)4.20144847
11DNA replication initiation (GO:0006270)4.08224364
12telomere maintenance via semi-conservative replication (GO:0032201)3.94033676
13nuclear envelope disassembly (GO:0051081)3.92333912
14membrane disassembly (GO:0030397)3.92333912
15cellular protein complex localization (GO:0034629)3.90971695
16NADH metabolic process (GO:0006734)3.84084832
17DNA replication-dependent nucleosome assembly (GO:0006335)3.81439587
18DNA replication-dependent nucleosome organization (GO:0034723)3.81439587
19protein localization to chromosome, centromeric region (GO:0071459)3.80723013
20peptidyl-arginine omega-N-methylation (GO:0035247)3.78355049
21protein complex localization (GO:0031503)3.77545514
22nucleobase biosynthetic process (GO:0046112)3.71913930
23IMP biosynthetic process (GO:0006188)3.65613573
24nuclear pore organization (GO:0006999)3.62167592
25glycolytic process (GO:0006096)3.57406742
26desmosome organization (GO:0002934)3.56780139
27nuclear pore complex assembly (GO:0051292)3.55468962
28establishment of viral latency (GO:0019043)3.55360142
29paraxial mesoderm development (GO:0048339)3.50473167
30DNA replication checkpoint (GO:0000076)3.47312160
31telomere maintenance via recombination (GO:0000722)3.45498344
32mitotic chromosome condensation (GO:0007076)3.43022582
33negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.42656222
34tricarboxylic acid cycle (GO:0006099)3.42126195
35mitotic recombination (GO:0006312)3.41839765
36mitotic sister chromatid segregation (GO:0000070)3.40497392
37maturation of SSU-rRNA (GO:0030490)3.39261498
38DNA duplex unwinding (GO:0032508)3.38622177
39regulation of NFAT protein import into nucleus (GO:0051532)3.37399014
40DNA geometric change (GO:0032392)3.35268827
41peptidyl-arginine methylation (GO:0018216)3.34844113
42peptidyl-arginine N-methylation (GO:0035246)3.34844113
43maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.32911655
44protein retention in ER lumen (GO:0006621)3.31519072
45heterochromatin organization (GO:0070828)3.31076656
46IMP metabolic process (GO:0046040)3.30178319
47regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.29512830
48mitotic metaphase plate congression (GO:0007080)3.29120531
49purine nucleobase biosynthetic process (GO:0009113)3.28820908
50sister chromatid segregation (GO:0000819)3.28348116
51glucose 6-phosphate metabolic process (GO:0051156)3.28173848
52regulation of translational fidelity (GO:0006450)3.28031909
53ribosome assembly (GO:0042255)3.26898816
54retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.24513113
55histone arginine methylation (GO:0034969)3.23158840
56regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.21876659
57pentose-phosphate shunt (GO:0006098)3.20042653
58nuclear envelope organization (GO:0006998)3.17579239
59telomere maintenance via telomere lengthening (GO:0010833)3.15560254
60actin-myosin filament sliding (GO:0033275)3.14965536
61muscle filament sliding (GO:0030049)3.14965536
62mitochondrial fusion (GO:0008053)3.12726723
63bundle of His cell to Purkinje myocyte communication (GO:0086069)3.12664168
64regulation of spindle organization (GO:0090224)3.11727967
65negative regulation of RNA splicing (GO:0033119)3.11146005
66DNA deamination (GO:0045006)3.05623090
67nucleotide-excision repair, DNA gap filling (GO:0006297)3.02852111
68NADPH regeneration (GO:0006740)3.02634957
69oxidative phosphorylation (GO:0006119)3.00508571
70mRNA stabilization (GO:0048255)3.00505177
71RNA stabilization (GO:0043489)3.00505177
72regulation of translational termination (GO:0006449)2.98434787
73cell-substrate junction assembly (GO:0007044)2.98418299
74regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.98176422
75gluconeogenesis (GO:0006094)2.95251849
76regulation of protein heterodimerization activity (GO:0043497)2.93928294
77ribosome biogenesis (GO:0042254)2.91957649
78nucleobase-containing small molecule interconversion (GO:0015949)2.91485873
79translesion synthesis (GO:0019985)2.90179635
80mitotic G1 DNA damage checkpoint (GO:0031571)2.90089480
81dosage compensation (GO:0007549)2.88210980
82nuclear envelope reassembly (GO:0031468)2.87911089
83mitotic nuclear envelope reassembly (GO:0007084)2.87911089
84translational initiation (GO:0006413)2.87165292
85folic acid metabolic process (GO:0046655)2.86958313
86regulation of RNA export from nucleus (GO:0046831)2.84125050
87negative regulation of chromosome segregation (GO:0051985)2.82580165
88negative regulation of mRNA processing (GO:0050686)2.81873702
89sarcoplasmic reticulum calcium ion transport (GO:0070296)2.81000539
90metaphase plate congression (GO:0051310)2.80458421
91viral transcription (GO:0019083)2.80143244
92positive regulation of chromosome segregation (GO:0051984)2.80074031
93base-excision repair (GO:0006284)2.80056905
94adherens junction assembly (GO:0034333)2.80010461
95epithelial cell-cell adhesion (GO:0090136)2.79697030
96hexose biosynthetic process (GO:0019319)2.77141886
97translational termination (GO:0006415)2.77134969
98histone-serine phosphorylation (GO:0035404)2.76024352
99mitotic spindle assembly checkpoint (GO:0007094)2.74919719
100spindle assembly checkpoint (GO:0071173)2.74350355
101ribosomal small subunit assembly (GO:0000028)2.74189557
102negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.73828899
103negative regulation of sister chromatid segregation (GO:0033046)2.73828899
104negative regulation of mitotic sister chromatid separation (GO:2000816)2.73828899
105negative regulation of mitotic sister chromatid segregation (GO:0033048)2.73828899
106proline biosynthetic process (GO:0006561)2.73797500
107translational elongation (GO:0006414)2.73664652
108postreplication repair (GO:0006301)2.72623575
109cell-substrate adherens junction assembly (GO:0007045)2.71446531
110focal adhesion assembly (GO:0048041)2.71446531
111regulation of chromosome segregation (GO:0051983)2.70637757
112protein localization to microtubule (GO:0035372)2.69418846
113DNA conformation change (GO:0071103)2.69329646
114regulation of mitotic spindle organization (GO:0060236)2.68924836
115protein localization to chromosome (GO:0034502)2.68643024
116monosaccharide biosynthetic process (GO:0046364)2.67093678
117epithelial cell differentiation involved in prostate gland development (GO:0060742)2.66554531
118pore complex assembly (GO:0046931)2.66360651
119kinetochore organization (GO:0051383)2.65877212
120attachment of spindle microtubules to kinetochore (GO:0008608)2.65571141
121spindle checkpoint (GO:0031577)2.65017761
122somatic hypermutation of immunoglobulin genes (GO:0016446)2.64933266
123somatic diversification of immune receptors via somatic mutation (GO:0002566)2.64933266
124negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.64748746
125ribonucleoprotein complex biogenesis (GO:0022613)2.64151272
126tetrahydrofolate metabolic process (GO:0046653)2.63581500
127pre-miRNA processing (GO:0031054)2.62373925
128anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.61620048
129nucleotide-sugar biosynthetic process (GO:0009226)2.61397875
130regulation of mitotic metaphase/anaphase transition (GO:0030071)2.61228170
131regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.61047239
132G1/S transition of mitotic cell cycle (GO:0000082)2.60715068
133cell cycle G1/S phase transition (GO:0044843)2.60715068
134membrane budding (GO:0006900)2.60703206
135actin-mediated cell contraction (GO:0070252)2.60643189
136establishment of chromosome localization (GO:0051303)2.60361524
137mitotic spindle checkpoint (GO:0071174)2.60125147
138de novo protein folding (GO:0006458)2.59475916
139positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.58597215
140establishment of integrated proviral latency (GO:0075713)2.58183884
141nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.57746977
142nucleoside salvage (GO:0043174)2.57682123
143regulation of mammary gland epithelial cell proliferation (GO:0033599)2.57360040
144protein maturation by protein folding (GO:0022417)2.57152876
145chromatin assembly or disassembly (GO:0006333)2.55812990
146regulation of histone H3-K9 methylation (GO:0051570)2.55574716
147spliceosomal snRNP assembly (GO:0000387)2.54844376
148regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.54498068
149de novo posttranslational protein folding (GO:0051084)2.53687509
150negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.53226845
151pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.52685589
152positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.52597753
153regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.52597753
154DNA replication-independent nucleosome organization (GO:0034724)2.52557642
155DNA replication-independent nucleosome assembly (GO:0006336)2.52557642
156mitotic sister chromatid cohesion (GO:0007064)2.51942894
157spliceosomal tri-snRNP complex assembly (GO:0000244)2.51853878
158gap junction assembly (GO:0016264)2.50767784
159regulation of nucleobase-containing compound transport (GO:0032239)2.49780697
160barbed-end actin filament capping (GO:0051016)2.49488581
161pyruvate metabolic process (GO:0006090)2.48559945
162glucose catabolic process (GO:0006007)2.48128659
163DNA topological change (GO:0006265)2.45681073
1643-UTR-mediated mRNA stabilization (GO:0070935)2.45333278
165tricarboxylic acid metabolic process (GO:0072350)2.43630111
166adenine nucleotide transport (GO:0051503)2.43105275
167maternal placenta development (GO:0001893)2.42923998
168chromosome condensation (GO:0030261)2.40850200

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.19191265
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.09990777
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.87230984
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.73183321
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.13054143
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.78952835
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.78114152
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.62683675
9MYC_22102868_ChIP-Seq_BL_Human2.45628363
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.41223163
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.41111918
12NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18260867
13AR_21909140_ChIP-Seq_LNCAP_Human2.13067379
14XRN2_22483619_ChIP-Seq_HELA_Human2.09944642
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.02378029
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.02071121
17ETS1_20019798_ChIP-Seq_JURKAT_Human1.97806755
18EST1_17652178_ChIP-ChIP_JURKAT_Human1.92673675
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.85506339
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.84910286
21E2F1_21310950_ChIP-Seq_MCF-7_Human1.81919315
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.80347466
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.74781834
24E2F1_18555785_ChIP-Seq_MESCs_Mouse1.74175432
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.69879653
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.69333894
27VDR_21846776_ChIP-Seq_THP-1_Human1.67060162
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.66997987
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.63110003
30DCP1A_22483619_ChIP-Seq_HELA_Human1.61794495
31* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60975133
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.59897305
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.57980420
34ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57396901
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57370121
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.53452879
37NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.53376666
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.53114877
39PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.52971357
40STAT3_1855785_ChIP-Seq_MESCs_Mouse1.51095265
41GABP_19822575_ChIP-Seq_HepG2_Human1.51017149
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50812968
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50354402
44VDR_23849224_ChIP-Seq_CD4+_Human1.49334248
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49097569
46CIITA_25753668_ChIP-Seq_RAJI_Human1.48540968
47TTF2_22483619_ChIP-Seq_HELA_Human1.47475369
48CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46956938
49KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.45584772
50ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44889451
51KLF4_18555785_ChIP-Seq_MESCs_Mouse1.41952437
52ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.41289496
53* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40662813
54FOXP3_21729870_ChIP-Seq_TREG_Human1.40181236
55KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.38516279
56SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.37998694
57* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36414397
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34290128
59DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34178680
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31186624
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.31096499
62CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.30500208
63KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29472651
64P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29117490
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29045070
66KDM5A_27292631_Chip-Seq_BREAST_Human1.28664986
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.25172497
68WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25166049
69ZNF263_19887448_ChIP-Seq_K562_Human1.24662032
70SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24237863
71TFEB_21752829_ChIP-Seq_HELA_Human1.23854825
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23648198
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22584585
74SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.18265707
75RACK7_27058665_Chip-Seq_MCF-7_Human1.18092546
76ELK3_25401928_ChIP-Seq_HUVEC_Human1.18056113
77ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14413288
78TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14336113
79* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.13416731
80ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12856616
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12623705
82WT1_19549856_ChIP-ChIP_CCG9911_Human1.11733774
83SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.11091968
84NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.10256252
85* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09621842
86HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06942386
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06797978
88ELK1_19687146_ChIP-ChIP_HELA_Human1.05906644
89NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05597635
90YY1_21170310_ChIP-Seq_MESCs_Mouse1.04993584
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04912157
92YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04810148
93ATF3_27146783_Chip-Seq_COLON_Human1.04763456
94KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04672718
95* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.04619498
96CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04595900
97HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01877226
98ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01416751
99RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01056615
100NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.00652773
101TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.00455427
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00094420
103TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99696836
104* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99093916
105ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98465993
106SOX17_20123909_ChIP-Seq_XEN_Mouse0.97057187
107KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.96848627
108KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.96848627
109* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96072026
110UTX_26944678_Chip-Seq_JUKART_Human0.95605442
111NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95318172
112NANOG_21062744_ChIP-ChIP_HESCs_Human0.93989023
113FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93964193
114SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93912597
115CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93860386
116SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92167639
117RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92052148
118KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91596013
119MAF_26560356_Chip-Seq_TH1_Human0.91417047
120* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90540034
121POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89331256
122TCF7_22412390_ChIP-Seq_EML_Mouse0.89061892
123KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88823064
124FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88164137
125CLOCK_20551151_ChIP-Seq_293T_Human0.88031326
126PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.87574067
127CHD1_26751641_Chip-Seq_LNCaP_Human0.87551642
128TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.87479924
129* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.86172670

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.86006294
2MP0010234_abnormal_vibrissa_follicle3.81253043
3MP0010352_gastrointestinal_tract_polyps3.53531567
4MP0004957_abnormal_blastocyst_morpholog3.41734724
5MP0010094_abnormal_chromosome_stability3.40390313
6MP0003111_abnormal_nucleus_morphology3.31904295
7MP0003077_abnormal_cell_cycle3.04437983
8MP0003705_abnormal_hypodermis_morpholog2.82311323
9MP0000751_myopathy2.62397748
10MP0008057_abnormal_DNA_replication2.59867453
11MP0003941_abnormal_skin_development2.56401963
12MP0005451_abnormal_body_composition2.56373184
13MP0000579_abnormal_nail_morphology2.54219583
14MP0002796_impaired_skin_barrier2.51179744
15MP0001730_embryonic_growth_arrest2.37621871
16MP0002396_abnormal_hematopoietic_system2.25925428
17MP0008007_abnormal_cellular_replicative2.22998858
18MP0005076_abnormal_cell_differentiation2.21333133
19MP0000350_abnormal_cell_proliferation2.09420398
20MP0008932_abnormal_embryonic_tissue2.08151397
21MP0000747_muscle_weakness2.05946561
22MP0003566_abnormal_cell_adhesion2.04503113
23MP0008260_abnormal_autophagy1.98214594
24MP0008058_abnormal_DNA_repair1.91203868
25MP0006054_spinal_hemorrhage1.91119582
26MP0000762_abnormal_tongue_morphology1.87528172
27MP0004185_abnormal_adipocyte_glucose1.87403882
28MP0004145_abnormal_muscle_electrophysio1.84764802
29MP0010030_abnormal_orbit_morphology1.75809480
30MP0005380_embryogenesis_phenotype1.69475797
31MP0001672_abnormal_embryogenesis/_devel1.69475797
32MP0000759_abnormal_skeletal_muscle1.68753809
33MP0005023_abnormal_wound_healing1.66564689
34MP0005409_darkened_coat_color1.66203013
35MP0000749_muscle_degeneration1.66185369
36MP0001697_abnormal_embryo_size1.65168701
37MP0005330_cardiomyopathy1.64660866
38MP0008438_abnormal_cutaneous_collagen1.63146773
39MP0010307_abnormal_tumor_latency1.62654963
40MP0003984_embryonic_growth_retardation1.61519392
41MP0004272_abnormal_basement_membrane1.60292090
42MP0004197_abnormal_fetal_growth/weight/1.60182991
43MP0002088_abnormal_embryonic_growth/wei1.59148138
44MP0004264_abnormal_extraembryonic_tissu1.57106730
45MP0000490_abnormal_crypts_of1.56875953
46MP0003123_paternal_imprinting1.56824282
47MP0009278_abnormal_bone_marrow1.56375606
48MP0002080_prenatal_lethality1.55200651
49MP0004858_abnormal_nervous_system1.54505576
50MP0003315_abnormal_perineum_morphology1.52963503
51MP0004808_abnormal_hematopoietic_stem1.51791488
52MP0002086_abnormal_extraembryonic_tissu1.49687696
53MP0002085_abnormal_embryonic_tissue1.46367854
54MP0003786_premature_aging1.42759902
55MP0003453_abnormal_keratinocyte_physiol1.41996185
56MP0002019_abnormal_tumor_incidence1.40376646
57MP0003806_abnormal_nucleotide_metabolis1.40260942
58MP0001545_abnormal_hematopoietic_system1.39674965
59MP0005397_hematopoietic_system_phenotyp1.39674965
60MP0002084_abnormal_developmental_patter1.39571404
61MP0000678_abnormal_parathyroid_gland1.37858864
62MP0003567_abnormal_fetal_cardiomyocyte1.33609465
63MP0000467_abnormal_esophagus_morphology1.32422639
64MP0002106_abnormal_muscle_physiology1.31830960
65MP0000537_abnormal_urethra_morphology1.30495506
66MP0009053_abnormal_anal_canal1.29475219
67MP0001299_abnormal_eye_distance/1.29177432
68MP0005257_abnormal_intraocular_pressure1.27910882
69MP0001216_abnormal_epidermal_layer1.27834203
70MP0001849_ear_inflammation1.26261956
71MP0004036_abnormal_muscle_relaxation1.24348827
72MP0000313_abnormal_cell_death1.21553382
73MP0005623_abnormal_meninges_morphology1.20965370
74MP0001915_intracranial_hemorrhage1.18820513
75MP0004233_abnormal_muscle_weight1.17565570
76MP0000733_abnormal_muscle_development1.14396187
77MP0004270_analgesia1.09661289
78MP0005275_abnormal_skin_tensile1.09562073
79MP0003890_abnormal_embryonic-extraembry1.07864483
80MP0009333_abnormal_splenocyte_physiolog1.05185261
81MP0000377_abnormal_hair_follicle1.03205510
82MP0000750_abnormal_muscle_regeneration1.02690473
83MP0003718_maternal_effect1.02154215
84MP0003091_abnormal_cell_migration1.02124174
85MP0005369_muscle_phenotype1.01980055
86MP0002697_abnormal_eye_size1.01666298
87MP0003279_aneurysm1.00649961
88MP0003385_abnormal_body_wall0.99652032
89MP0003221_abnormal_cardiomyocyte_apopto0.99122727
90MP0000358_abnormal_cell_content/0.98869405
91MP0001188_hyperpigmentation0.97566482
92MP0006035_abnormal_mitochondrial_morpho0.96555048
93MP0005666_abnormal_adipose_tissue0.95639080
94MP0000703_abnormal_thymus_morphology0.94888068
95MP0003121_genomic_imprinting0.94737656
96MP0005621_abnormal_cell_physiology0.94730031
97MP0002098_abnormal_vibrissa_morphology0.94558629
98MP0005360_urolithiasis0.94249829
99MP0009697_abnormal_copulation0.92963474
100MP0005384_cellular_phenotype0.90593163
101* MP0002722_abnormal_immune_system0.89541494
102MP0000858_altered_metastatic_potential0.89273327
103MP0005501_abnormal_skin_physiology0.87735529
104MP0001243_abnormal_dermal_layer0.87550825
105MP0009840_abnormal_foam_cell0.86867812
106MP0002398_abnormal_bone_marrow0.86264461
107MP0002111_abnormal_tail_morphology0.84440968
108MP0001340_abnormal_eyelid_morphology0.84253809
109MP0002822_catalepsy0.83526427
110MP0003119_abnormal_digestive_system0.81530057
111* MP0000689_abnormal_spleen_morphology0.80580670
112MP0010630_abnormal_cardiac_muscle0.80519546
113MP0004084_abnormal_cardiac_muscle0.79698563
114MP0006138_congestive_heart_failure0.79084738
115MP0002269_muscular_atrophy0.78762602
116MP0000462_abnormal_digestive_system0.78573478
117MP0001661_extended_life_span0.78445462
118MP0002060_abnormal_skin_morphology0.78055386
119MP0000566_synostosis0.77874913
120MP0000428_abnormal_craniofacial_morphol0.77479602
121MP0001346_abnormal_lacrimal_gland0.76710175
122MP0002972_abnormal_cardiac_muscle0.75782696
123MP0002089_abnormal_postnatal_growth/wei0.74784616
124MP0002925_abnormal_cardiovascular_devel0.72046996
125MP0003115_abnormal_respiratory_system0.71312644
126MP0000477_abnormal_intestine_morphology0.69963808
127MP0008770_decreased_survivor_rate0.69948373
128MP0002429_abnormal_blood_cell0.69043889
129MP0001293_anophthalmia0.68750619
130MP0004947_skin_inflammation0.66357957
131MP0002877_abnormal_melanocyte_morpholog0.65717582
132MP0003448_altered_tumor_morphology0.64854693
133MP0000266_abnormal_heart_morphology0.63556800
134MP0002092_abnormal_eye_morphology0.63072963
135MP0004087_abnormal_muscle_fiber0.62882258
136* MP0000598_abnormal_liver_morphology0.62458972
137MP0000685_abnormal_immune_system0.62387640
138MP0009672_abnormal_birth_weight0.61671940
139MP0001348_abnormal_lacrimal_gland0.61144026
140MP0003436_decreased_susceptibility_to0.61108259
141MP0001727_abnormal_embryo_implantation0.60741412
142MP0002282_abnormal_trachea_morphology0.60696141
143MP0002970_abnormal_white_adipose0.60546926
144MP0009931_abnormal_skin_appearance0.59386849
145MP0003300_gastrointestinal_ulcer0.58504928
146MP0005503_abnormal_tendon_morphology0.57489168
147MP0002932_abnormal_joint_morphology0.57421637

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)4.98293386
2Muscle fiber inclusion bodies (HP:0100299)4.75687304
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.65222002
4Exercise-induced muscle cramps (HP:0003710)4.47386207
5Centrally nucleated skeletal muscle fibers (HP:0003687)3.87649134
6Exercise-induced myalgia (HP:0003738)3.75337866
7Protrusio acetabuli (HP:0003179)3.70469962
8Selective tooth agenesis (HP:0001592)3.67953847
9Type 1 muscle fiber predominance (HP:0003803)3.61511108
10Distal lower limb amyotrophy (HP:0008944)3.48875902
11Progressive muscle weakness (HP:0003323)3.19952396
12Myopathic facies (HP:0002058)3.16993194
13Ependymoma (HP:0002888)3.13713924
14Rhabdomyolysis (HP:0003201)2.93053416
15Colon cancer (HP:0003003)2.92575958
16Abnormality of the anterior horn cell (HP:0006802)2.91244596
17Degeneration of anterior horn cells (HP:0002398)2.91244596
18Lower limb amyotrophy (HP:0007210)2.82393999
19Cholecystitis (HP:0001082)2.82029997
20Abnormal gallbladder physiology (HP:0012438)2.82029997
21Right ventricular cardiomyopathy (HP:0011663)2.80601472
22Trismus (HP:0000211)2.80313439
23Ankle contracture (HP:0006466)2.77351802
24Abnormality of the calcaneus (HP:0008364)2.76856438
25Muscle stiffness (HP:0003552)2.74394489
26Myoglobinuria (HP:0002913)2.72340380
27Termporal pattern (HP:0011008)2.71176366
28Insidious onset (HP:0003587)2.71176366
29Distal lower limb muscle weakness (HP:0009053)2.70300585
30Birth length less than 3rd percentile (HP:0003561)2.64718612
31Breast hypoplasia (HP:0003187)2.64502999
32Abnormality of skeletal muscle fiber size (HP:0012084)2.63894179
33Deviation of the thumb (HP:0009603)2.62015299
34Rimmed vacuoles (HP:0003805)2.60816162
35Patellar aplasia (HP:0006443)2.58761719
36Multiple enchondromatosis (HP:0005701)2.57554006
37Proximal placement of thumb (HP:0009623)2.56250891
38Premature rupture of membranes (HP:0001788)2.55750456
39EMG: myopathic abnormalities (HP:0003458)2.49902966
40Limb-girdle muscle atrophy (HP:0003797)2.49681302
41Atrophic scars (HP:0001075)2.49630054
42Onycholysis (HP:0001806)2.47702169
43Fragile nails (HP:0001808)2.46460215
44Ragged-red muscle fibers (HP:0003200)2.41406860
45Aplasia/Hypoplasia of the patella (HP:0006498)2.39686301
46Mildly elevated creatine phosphokinase (HP:0008180)2.38230133
47Abnormality of glycolysis (HP:0004366)2.34235509
48Abnormality of the astrocytes (HP:0100707)2.33175921
49Astrocytoma (HP:0009592)2.33175921
50Amniotic constriction ring (HP:0009775)2.32323807
51Abnormality of placental membranes (HP:0011409)2.32323807
52Distal arthrogryposis (HP:0005684)2.28572997
53Oral leukoplakia (HP:0002745)2.26815729
54Reticulocytopenia (HP:0001896)2.25927488
55Medulloblastoma (HP:0002885)2.17771148
56Increased density of long bones (HP:0006392)2.17391451
57Abnormality of nail color (HP:0100643)2.16205209
58Round ear (HP:0100830)2.15455353
59Cellulitis (HP:0100658)2.15309664
60Cerebral aneurysm (HP:0004944)2.15029201
61Ventricular tachycardia (HP:0004756)2.14551683
62Ulnar bowing (HP:0003031)2.13756561
63Increased variability in muscle fiber diameter (HP:0003557)2.13134556
64Spinal rigidity (HP:0003306)2.10492431
6511 pairs of ribs (HP:0000878)2.10267317
66Achilles tendon contracture (HP:0001771)2.10204742
67Short 4th metacarpal (HP:0010044)2.08805073
68Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.08805073
69Abnormality of the salivary glands (HP:0010286)2.08714730
70Carpal bone hypoplasia (HP:0001498)2.07906640
71Angiofibromas (HP:0010615)2.07866827
72Adenoma sebaceum (HP:0009720)2.07866827
73Milia (HP:0001056)2.07565707
74Slender long bone (HP:0003100)2.07136991
75Atrophy/Degeneration involving motor neurons (HP:0007373)2.06487663
76Cortical dysplasia (HP:0002539)2.06413072
77Neck muscle weakness (HP:0000467)2.05980407
78Progressive external ophthalmoplegia (HP:0000590)2.05932688
79Difficulty climbing stairs (HP:0003551)2.05250356
80Subaortic stenosis (HP:0001682)2.04009827
81Abnormality of the left ventricular outflow tract (HP:0011103)2.04009827
82Wrist flexion contracture (HP:0001239)2.03918319
83Pterygium (HP:0001059)2.03391250
84Pili torti (HP:0003777)2.02560586
85Missing ribs (HP:0000921)2.01845646
86Ridged nail (HP:0001807)2.01781105
87Pelvic girdle muscle weakness (HP:0003749)2.00937475
88Insomnia (HP:0100785)1.99459515
89Rough bone trabeculation (HP:0100670)1.99021137
90Metaphyseal cupping (HP:0003021)1.98461382
91Neoplasm of the pancreas (HP:0002894)1.94928321
92High pitched voice (HP:0001620)1.94467148
93Abnormality of cells of the erythroid lineage (HP:0012130)1.93555513
94Increased serum pyruvate (HP:0003542)1.93090955
95Papilloma (HP:0012740)1.91789213
96Verrucae (HP:0200043)1.91789213
97Increased nuchal translucency (HP:0010880)1.91205193
98Long palpebral fissure (HP:0000637)1.89850441
99Abnormal number of incisors (HP:0011064)1.89837596
100Genu recurvatum (HP:0002816)1.89730346
101Glioma (HP:0009733)1.89447814
102Basal cell carcinoma (HP:0002671)1.88819880
103Microvesicular hepatic steatosis (HP:0001414)1.87416343
104Calcaneovalgus deformity (HP:0001848)1.86883402
105Cervical subluxation (HP:0003308)1.86310080
106Abnormality of the umbilical cord (HP:0010881)1.86244268
107Microretrognathia (HP:0000308)1.86110614
108Glossoptosis (HP:0000162)1.85521677
109Limb-girdle muscle weakness (HP:0003325)1.85433837
110Rhabdomyosarcoma (HP:0002859)1.83724913
111Plantar hyperkeratosis (HP:0007556)1.82727288
112Shallow orbits (HP:0000586)1.81644955
113Ankyloglossia (HP:0010296)1.80824671
114Hand muscle atrophy (HP:0009130)1.80797973
115Abnormal number of erythroid precursors (HP:0012131)1.80100370
116Absent thumb (HP:0009777)1.79070668
117Ulnar deviation of the wrist (HP:0003049)1.77857093
118Back pain (HP:0003418)1.77802805
119Increased connective tissue (HP:0009025)1.77738327
120Thick nail (HP:0001805)1.77419798
121Nail dystrophy (HP:0008404)1.77122251
122Hypoplasia of the capital femoral epiphysis (HP:0003090)1.76644733
123Thrombocytosis (HP:0001894)1.75315163
124Cutaneous melanoma (HP:0012056)1.74538755
125Poor head control (HP:0002421)1.74440222
126Dilatation of the ascending aorta (HP:0005111)1.73511056
127Muscle fibrillation (HP:0010546)1.72958024
128Agnosia (HP:0010524)1.72076697
129Atresia of the external auditory canal (HP:0000413)1.71855347
130Abnormalities of placenta or umbilical cord (HP:0001194)1.71499135
131Abnormality of the Achilles tendon (HP:0005109)1.70953798
132Premature ovarian failure (HP:0008209)1.70833450
133Aplasia/hypoplasia of the humerus (HP:0006507)1.70577155
134Cholelithiasis (HP:0001081)1.70137367
135Fragile skin (HP:0001030)1.69483104
136Squamous cell carcinoma (HP:0002860)1.68295741
137Reticulocytosis (HP:0001923)1.67948131
138Breech presentation (HP:0001623)1.67345302
139Distal upper limb amyotrophy (HP:0007149)1.66390276
140Upper limb amyotrophy (HP:0009129)1.66390276
141Bowel diverticulosis (HP:0005222)1.65507650
142Tongue fasciculations (HP:0001308)1.65504799
143Peritonitis (HP:0002586)1.65067091
144Absent eyelashes (HP:0000561)1.62721695
145Abnormality of oral frenula (HP:0000190)1.62326929
146Personality changes (HP:0000751)1.62187567
147Abnormality of the hip-girdle musculature (HP:0001445)1.61334405
148Abnormality of the musculature of the pelvis (HP:0001469)1.61334405
149Fused cervical vertebrae (HP:0002949)1.61296097
150Reduced subcutaneous adipose tissue (HP:0003758)1.61117443
151Absent radius (HP:0003974)1.60668682
152Deformed tarsal bones (HP:0008119)1.59589115
153Hypoplasia of the pons (HP:0012110)1.59032509
154Shoulder girdle muscle weakness (HP:0003547)1.58740808
155Hyperacusis (HP:0010780)1.58023653
156Generalized amyotrophy (HP:0003700)1.57335297
157Bicuspid aortic valve (HP:0001647)1.56851464
158Difficulty running (HP:0009046)1.56152844
159Sparse eyelashes (HP:0000653)1.56050432
160Overlapping toe (HP:0001845)1.55864328
161Malignant gastrointestinal tract tumors (HP:0006749)1.55459827
162Gastrointestinal carcinoma (HP:0002672)1.55459827
163Spastic diplegia (HP:0001264)1.55132023
164Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.54835039
165Short humerus (HP:0005792)1.53719596
166Popliteal pterygium (HP:0009756)1.53582567
167Neoplasm of striated muscle (HP:0009728)1.53221115
168Abnormality of the motor neurons (HP:0002450)1.52750166
169Abnormal neuron morphology (HP:0012757)1.52750166
170Aplastic anemia (HP:0001915)1.52533618
171Muscle hypertrophy of the lower extremities (HP:0008968)1.52376189
172Impulsivity (HP:0100710)1.52220854
173Uterine leiomyosarcoma (HP:0002891)1.51892478
174Leiomyosarcoma (HP:0100243)1.51892478
175Flat acetabular roof (HP:0003180)1.51133980

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K103.38648832
2EEF2K3.22947379
3WEE13.14307593
4ARAF3.04405654
5BUB13.00827520
6CDC72.90745157
7TRIB32.64965779
8PKN22.40136902
9SMG12.38394935
10NEK12.38161554
11MAP3K92.35542988
12TESK22.33761108
13OBSCN2.22885189
14EPHA22.19541341
15NEK22.17787479
16PRPF4B2.17198511
17RPS6KB22.14068256
18PASK2.12952305
19MST1R2.10187710
20ERN12.08087906
21ACVR1B2.03002725
22CDK122.01605601
23SCYL21.99647288
24MET1.97931195
25STK101.96783997
26KSR21.92764405
27PAK41.61289669
28LRRK21.59202518
29EIF2AK11.57059426
30CDK191.55026307
31RIPK11.54557565
32TTK1.52798869
33PBK1.52211574
34MAP3K81.51057260
35BRSK21.50853163
36TESK11.50125459
37RPS6KA41.47440663
38TGFBR11.45458304
39CDK71.40295892
40PIM21.36590552
41KSR11.34715763
42PLK11.33664321
43MAP3K131.32255894
44TTN1.30620019
45CDK41.30300252
46TSSK61.27072477
47BRAF1.25105485
48AURKB1.24808429
49NME21.23697521
50DYRK31.22030230
51MAPKAPK31.21211000
52MAP3K111.20335284
53NTRK11.17440882
54BRSK11.17347031
55MAP3K61.14525708
56ATR1.11908473
57PDGFRA1.10053763
58LATS21.09136948
59BCR1.09068863
60RAF11.01602904
61LIMK11.00048404
62FLT30.94680495
63BRD40.94282423
64EIF2AK30.94027575
65AURKA0.91908831
66MTOR0.86971615
67CHEK10.86421141
68STK40.84874467
69PAK20.84562868
70EPHB10.84070539
71CHEK20.83913332
72DDR20.83800121
73VRK10.83306401
74TAOK20.82896877
75PLK30.82851101
76CDK11A0.82417515
77TLK10.81861398
78CDK180.81656693
79ILK0.80512062
80CDK140.80432123
81LATS10.80035538
82CDK150.79918623
83KDR0.79728770
84VRK20.77639326
85CDK60.76204749
86EPHB20.76101862
87SIK10.75742570
88TRPM70.75305420
89LMTK20.74295157
90GRK60.74167353
91PIM10.73561574
92MAP3K120.72122991
93PLK40.72069125
94MAP2K30.71331003
95PAK10.70649488
96ICK0.69834511
97ALK0.69591993
98CDK90.69097169
99NME10.66796715
100PTK60.66332232
101DMPK0.66330322
102SIK30.65573489
103CLK10.63040706
104CDK20.62846172
105MAP4K10.61442980
106STK30.60673497
107PHKG20.60421162
108PHKG10.60421162
109MKNK10.59885514
110MELK0.56234357
111SRPK10.53810029
112CCNB10.53676740
113ZAP700.53621008
114TAF10.51832298
115BLK0.51105133
116MATK0.50854697
117MAP3K50.50746457
118MAP3K30.49451478
119MAPK110.49079037
120ATM0.47920829
121IRAK30.44145009
122MAP3K10.43214428
123CSNK1A1L0.42711787
124MAPKAPK20.40789143
125CDK10.39990203
126FGFR40.39770779
127CSNK2A20.38881585
128AKT20.37671672
129FGFR10.36612008
130DAPK10.36575782
131MOS0.36293389
132CSNK1G30.35715999
133BMX0.34742034
134DYRK1B0.34285875
135RET0.33926720
136CSF1R0.32278837
137CSNK2A10.31472268
138PTK20.31365339
139CDK80.30783744
140NEK90.30474812
141STK240.30339355
142TAOK10.28520009
143TYRO30.27609036
144DYRK20.27508188
145PRKCI0.27420928

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.62564256
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.02296057
3Mismatch repair_Homo sapiens_hsa034303.65520013
4Base excision repair_Homo sapiens_hsa034102.95888603
5One carbon pool by folate_Homo sapiens_hsa006702.76447179
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.76160019
7Cell cycle_Homo sapiens_hsa041102.75365718
8RNA transport_Homo sapiens_hsa030132.74151002
9Spliceosome_Homo sapiens_hsa030402.71879412
10Proteasome_Homo sapiens_hsa030502.63515500
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.38140792
12Ribosome_Homo sapiens_hsa030102.27922936
13Nucleotide excision repair_Homo sapiens_hsa034202.27664082
14Homologous recombination_Homo sapiens_hsa034402.15353451
15Pyrimidine metabolism_Homo sapiens_hsa002401.86141578
16Non-homologous end-joining_Homo sapiens_hsa034501.85562646
17p53 signaling pathway_Homo sapiens_hsa041151.84581704
18RNA polymerase_Homo sapiens_hsa030201.71998950
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45917793
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.44284119
21Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.41430316
22Fatty acid elongation_Homo sapiens_hsa000621.40025510
23Pyruvate metabolism_Homo sapiens_hsa006201.34869129
24Biosynthesis of amino acids_Homo sapiens_hsa012301.32267762
25mRNA surveillance pathway_Homo sapiens_hsa030151.30620813
26Viral carcinogenesis_Homo sapiens_hsa052031.28760598
27Arginine biosynthesis_Homo sapiens_hsa002201.28506979
28RNA degradation_Homo sapiens_hsa030181.25710856
29Fanconi anemia pathway_Homo sapiens_hsa034601.23606743
30Epstein-Barr virus infection_Homo sapiens_hsa051691.21302836
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15542413
32Small cell lung cancer_Homo sapiens_hsa052221.14893736
33MicroRNAs in cancer_Homo sapiens_hsa052061.13579805
34Selenocompound metabolism_Homo sapiens_hsa004501.13012482
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10734391
36Pentose phosphate pathway_Homo sapiens_hsa000301.08901969
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07609158
38Chronic myeloid leukemia_Homo sapiens_hsa052201.04655719
39HTLV-I infection_Homo sapiens_hsa051661.04242277
40Systemic lupus erythematosus_Homo sapiens_hsa053221.03704446
41Bladder cancer_Homo sapiens_hsa052190.99589547
42Cyanoamino acid metabolism_Homo sapiens_hsa004600.99050782
43Shigellosis_Homo sapiens_hsa051310.98464843
44Carbon metabolism_Homo sapiens_hsa012000.96601918
45Insulin signaling pathway_Homo sapiens_hsa049100.93423202
46Antigen processing and presentation_Homo sapiens_hsa046120.90274234
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90244642
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88965650
49Colorectal cancer_Homo sapiens_hsa052100.88334790
50Arginine and proline metabolism_Homo sapiens_hsa003300.87522861
51Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87359296
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.86932228
53Thyroid cancer_Homo sapiens_hsa052160.86767654
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.86705381
55Adherens junction_Homo sapiens_hsa045200.86473200
56Viral myocarditis_Homo sapiens_hsa054160.86267733
57Hippo signaling pathway_Homo sapiens_hsa043900.86250667
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85782865
59Legionellosis_Homo sapiens_hsa051340.85347297
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.84234123
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.82799002
62Apoptosis_Homo sapiens_hsa042100.81938310
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81444155
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80786621
65Dilated cardiomyopathy_Homo sapiens_hsa054140.77248699
66Basal transcription factors_Homo sapiens_hsa030220.77092774
67Primary immunodeficiency_Homo sapiens_hsa053400.75508778
68Phenylalanine metabolism_Homo sapiens_hsa003600.74072469
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72085947
70Renal cell carcinoma_Homo sapiens_hsa052110.71653692
71Herpes simplex infection_Homo sapiens_hsa051680.71610923
72Oocyte meiosis_Homo sapiens_hsa041140.71538772
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70787167
74ErbB signaling pathway_Homo sapiens_hsa040120.70467092
75Salmonella infection_Homo sapiens_hsa051320.70223489
76Proteoglycans in cancer_Homo sapiens_hsa052050.70155767
77mTOR signaling pathway_Homo sapiens_hsa041500.69946557
78Vibrio cholerae infection_Homo sapiens_hsa051100.69114646
79Folate biosynthesis_Homo sapiens_hsa007900.68688600
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67393776
81Hepatitis B_Homo sapiens_hsa051610.66029518
82Steroid biosynthesis_Homo sapiens_hsa001000.64064153
83Purine metabolism_Homo sapiens_hsa002300.62474713
84N-Glycan biosynthesis_Homo sapiens_hsa005100.62457565
85TGF-beta signaling pathway_Homo sapiens_hsa043500.60912178
86Pancreatic cancer_Homo sapiens_hsa052120.60581013
87Cardiac muscle contraction_Homo sapiens_hsa042600.60337597
88Acute myeloid leukemia_Homo sapiens_hsa052210.59506589
89AMPK signaling pathway_Homo sapiens_hsa041520.59369910
90Sulfur relay system_Homo sapiens_hsa041220.58789399
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56785922
92Glutathione metabolism_Homo sapiens_hsa004800.54923201
93HIF-1 signaling pathway_Homo sapiens_hsa040660.54505409
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54288394
95Basal cell carcinoma_Homo sapiens_hsa052170.54029361
96Fatty acid metabolism_Homo sapiens_hsa012120.53913456
97Fructose and mannose metabolism_Homo sapiens_hsa000510.52512464
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51320791
99Focal adhesion_Homo sapiens_hsa045100.51109990
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.51105885
101Starch and sucrose metabolism_Homo sapiens_hsa005000.50739294
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50701164
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50138181
104Non-small cell lung cancer_Homo sapiens_hsa052230.49559926
105B cell receptor signaling pathway_Homo sapiens_hsa046620.49439920
106Notch signaling pathway_Homo sapiens_hsa043300.49251686
107Lysine degradation_Homo sapiens_hsa003100.47958869
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47941658
109Prion diseases_Homo sapiens_hsa050200.47604316
110Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46089142
111Glucagon signaling pathway_Homo sapiens_hsa049220.44310485
112Galactose metabolism_Homo sapiens_hsa000520.42475968
113Endometrial cancer_Homo sapiens_hsa052130.42241584
114Pathways in cancer_Homo sapiens_hsa052000.41878227
115Glioma_Homo sapiens_hsa052140.41140221
116Gap junction_Homo sapiens_hsa045400.40379692
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39910331
118Axon guidance_Homo sapiens_hsa043600.38485948
119Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37516380
120Sulfur metabolism_Homo sapiens_hsa009200.35922503
121Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35620429
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.35351717
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.34077372
124Amoebiasis_Homo sapiens_hsa051460.33787657
125Prostate cancer_Homo sapiens_hsa052150.33678757
126Wnt signaling pathway_Homo sapiens_hsa043100.31367706
127VEGF signaling pathway_Homo sapiens_hsa043700.31305355
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30271575
129Leishmaniasis_Homo sapiens_hsa051400.30015523
130Toxoplasmosis_Homo sapiens_hsa051450.28687098
131Tight junction_Homo sapiens_hsa045300.28511811
132ECM-receptor interaction_Homo sapiens_hsa045120.28377845
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28198453
134Measles_Homo sapiens_hsa051620.26438141

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