PREX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.95391404
2negative regulation of cell killing (GO:0031342)5.95391404
3positive regulation of gamma-delta T cell activation (GO:0046645)5.56459637
4negative thymic T cell selection (GO:0045060)4.72546284
5negative T cell selection (GO:0043383)4.68770216
6detection of other organism (GO:0098543)4.64354508
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.60913331
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.60913331
9antigen processing and presentation of endogenous antigen (GO:0019883)4.47096386
10response to peptidoglycan (GO:0032494)4.46101945
11detection of bacterium (GO:0016045)4.33887563
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.33864677
13regulation of gamma-delta T cell differentiation (GO:0045586)4.33397298
14regulation of B cell receptor signaling pathway (GO:0050855)4.28257735
15detection of molecule of bacterial origin (GO:0032490)4.22963546
16NIK/NF-kappaB signaling (GO:0038061)4.22128656
17T cell migration (GO:0072678)4.19333682
18regulation of gamma-delta T cell activation (GO:0046643)4.17058122
19positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.07694748
20detection of external biotic stimulus (GO:0098581)4.07494422
21positive thymic T cell selection (GO:0045059)4.02275123
22negative regulation of interleukin-12 production (GO:0032695)3.99683474
23positive regulation by organism of defense response of other organism involved in symbiotic interact3.98823414
24modulation by symbiont of host immune response (GO:0052553)3.98823414
25positive regulation by symbiont of host defense response (GO:0052509)3.98823414
26modulation by symbiont of host defense response (GO:0052031)3.98823414
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.98823414
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.98823414
29positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.98429854
30negative regulation of lymphocyte mediated immunity (GO:0002707)3.94057400
31thymic T cell selection (GO:0045061)3.83770905
32response to muramyl dipeptide (GO:0032495)3.70097398
33macrophage activation (GO:0042116)3.69257874
34T cell selection (GO:0045058)3.67888532
35negative regulation of erythrocyte differentiation (GO:0045647)3.63396415
36negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.62687857
37tolerance induction (GO:0002507)3.61895048
38response to interleukin-15 (GO:0070672)3.60701161
39positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.59536334
40positive T cell selection (GO:0043368)3.59089199
41negative regulation of leukocyte mediated immunity (GO:0002704)3.58034883
42detection of biotic stimulus (GO:0009595)3.57578673
43activated T cell proliferation (GO:0050798)3.55501766
44macrophage activation involved in immune response (GO:0002281)3.54543700
45leukocyte aggregation (GO:0070486)3.54113370
46negative regulation of T cell mediated immunity (GO:0002710)3.52712073
47respiratory burst (GO:0045730)3.52533225
48regulation of interleukin-12 biosynthetic process (GO:0045075)3.49839661
49regulation of interferon-beta biosynthetic process (GO:0045357)3.49680923
50cellular response to interleukin-15 (GO:0071350)3.46468254
51regulation of mast cell degranulation (GO:0043304)3.39296397
52positive regulation of antigen processing and presentation (GO:0002579)3.36037085
53B cell receptor signaling pathway (GO:0050853)3.35645350
54myeloid dendritic cell differentiation (GO:0043011)3.33783997
55myeloid dendritic cell activation (GO:0001773)3.28604864
56regulation of myeloid leukocyte mediated immunity (GO:0002886)3.26668116
57neutrophil activation involved in immune response (GO:0002283)3.26133450
58positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.24069199
59regulation of leukocyte degranulation (GO:0043300)3.22990975
60regulation of B cell differentiation (GO:0045577)3.20042089
61positive regulation of B cell differentiation (GO:0045579)3.19929469
62leukocyte migration involved in inflammatory response (GO:0002523)3.18704079
63neutrophil mediated immunity (GO:0002446)3.18122975
64interferon-gamma production (GO:0032609)3.17825766
65myeloid cell activation involved in immune response (GO:0002275)3.12436285
66regulation of T-helper 2 cell differentiation (GO:0045628)3.10148561
67production of molecular mediator involved in inflammatory response (GO:0002532)3.10025384
68regulation of mast cell activation involved in immune response (GO:0033006)3.08930349
69positive regulation of cellular amide metabolic process (GO:0034250)3.08607668
70negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.08283169
71positive regulation of mast cell activation (GO:0033005)3.07075536
72regulation of T cell tolerance induction (GO:0002664)3.06969374
73JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.06644714
74regulation of natural killer cell mediated immunity (GO:0002715)3.06644625
75regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.06644625
76interferon-gamma-mediated signaling pathway (GO:0060333)3.04354423
77regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.99548113
78regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.97723002
79lymphocyte migration (GO:0072676)2.94112905
80regulation of regulated secretory pathway (GO:1903305)2.93245294
81leukocyte cell-cell adhesion (GO:0007159)2.91581191
82lipopolysaccharide-mediated signaling pathway (GO:0031663)2.91365877
83cellular extravasation (GO:0045123)2.90387699
84natural killer cell differentiation (GO:0001779)2.89271078
85defense response to protozoan (GO:0042832)2.89176761
86regulation of mast cell activation (GO:0033003)2.87373469
87T cell costimulation (GO:0031295)2.86912086
88T cell receptor signaling pathway (GO:0050852)2.84145460
89antigen receptor-mediated signaling pathway (GO:0050851)2.83478117
90positive regulation of interleukin-2 production (GO:0032743)2.82646057
91mast cell activation (GO:0045576)2.82312683
92mature B cell differentiation (GO:0002335)2.81342175
93positive regulation of interferon-alpha production (GO:0032727)2.80938816
94myeloid leukocyte mediated immunity (GO:0002444)2.80530756
95lymphocyte costimulation (GO:0031294)2.80463984
96regulation of alpha-beta T cell proliferation (GO:0046640)2.79934440
97regulation of dendritic cell antigen processing and presentation (GO:0002604)2.79100613
98natural killer cell activation (GO:0030101)2.79081832
99positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.78871392
100leukocyte degranulation (GO:0043299)2.78786610
101immunoglobulin mediated immune response (GO:0016064)2.78453043
102microglial cell activation (GO:0001774)2.75538894
103regulation of antigen processing and presentation (GO:0002577)2.74195985
104regulation of macrophage cytokine production (GO:0010935)2.72287092
105positive regulation of Cdc42 GTPase activity (GO:0043089)2.71149631
106regulation of interferon-alpha production (GO:0032647)2.68009654
107interferon-gamma secretion (GO:0072643)2.67950774
108regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.67329505
109negative regulation of phagocytosis (GO:0050765)2.67263446
110negative regulation of type 2 immune response (GO:0002829)2.66934136
111dendritic cell differentiation (GO:0097028)2.66678644
112* neutrophil activation (GO:0042119)2.66591726
113response to type I interferon (GO:0034340)2.65394757
114type I interferon signaling pathway (GO:0060337)2.63029364
115cellular response to type I interferon (GO:0071357)2.63029364
116regulation of ARF GTPase activity (GO:0032312)2.62599775
117B cell homeostasis (GO:0001782)2.62025323
118T cell proliferation (GO:0042098)2.61964649
119regulation of tolerance induction (GO:0002643)2.61597428
120regulation of ARF protein signal transduction (GO:0032012)2.60091638
121* granulocyte activation (GO:0036230)2.60069434
122regulation of type I interferon-mediated signaling pathway (GO:0060338)2.58090437
123response to host immune response (GO:0052572)2.56091881
124response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.56091881
125regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.54644675
126response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.54621617
127response to host (GO:0075136)2.54621617
128response to host defenses (GO:0052200)2.54621617
129positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.54052540
130immune response-activating cell surface receptor signaling pathway (GO:0002429)2.53525429
131germinal center formation (GO:0002467)2.52697624
132positive regulation of Rap GTPase activity (GO:0032854)2.52530900
133mast cell activation involved in immune response (GO:0002279)2.52193705
134mast cell degranulation (GO:0043303)2.52193705
135antigen processing and presentation via MHC class Ib (GO:0002475)2.51854115
136negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.51242150
137regulation of isotype switching to IgG isotypes (GO:0048302)2.50647508
138positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.50457107
139positive regulation of natural killer cell mediated immunity (GO:0002717)2.50457107

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.13583173
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.03125799
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.25356343
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.08678006
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.32599325
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.24724018
7RUNX_20019798_ChIP-Seq_JUKART_Human3.18136480
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.16155751
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.14387189
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.13710567
11* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.08942130
12VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.99061239
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.82395101
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.76456531
15* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.73382670
16* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.59632715
17MYC_22102868_ChIP-Seq_BL_Human2.59404642
18SCL_19346495_ChIP-Seq_HPC-7_Human2.40362337
19MAF_26560356_Chip-Seq_TH1_Human2.39918884
20* VDR_21846776_ChIP-Seq_THP-1_Human2.37262370
21KDM2B_26808549_Chip-Seq_SUP-B15_Human2.36532449
22* TCF7_22412390_ChIP-Seq_EML_Mouse2.35575650
23MYB_26560356_Chip-Seq_TH2_Human2.33533651
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.29019552
25KDM2B_26808549_Chip-Seq_DND41_Human2.22509185
26* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.21037612
27* SPI1_23127762_ChIP-Seq_K562_Human2.17893282
28BP1_19119308_ChIP-ChIP_Hs578T_Human2.16520425
29KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.11535045
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.06349599
31* VDR_24763502_ChIP-Seq_THP-1_Human2.06242374
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.99110321
33MYB_26560356_Chip-Seq_TH1_Human1.93314253
34KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.93208127
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.92700825
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.92525948
37UTX_26944678_Chip-Seq_JUKART_Human1.88554522
38* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.82452467
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.79325972
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.75513729
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.75019921
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.73528737
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.73312529
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.70746523
45GATA3_27048872_Chip-Seq_THYMUS_Human1.66452976
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64936338
47NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.64299595
48KDM2B_26808549_Chip-Seq_JURKAT_Human1.61734141
49* SMAD_19615063_ChIP-ChIP_OVARY_Human1.61670528
50* VDR_24787735_ChIP-Seq_THP-1_Human1.59575569
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.58210301
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.57833463
53SPI1_23547873_ChIP-Seq_NB4_Human1.57550288
54* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45729330
55MAF_26560356_Chip-Seq_TH2_Human1.45711252
56GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44562541
57* ELK3_25401928_ChIP-Seq_HUVEC_Human1.38690268
58PU_27001747_Chip-Seq_BMDM_Mouse1.38014293
59* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33381782
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.33159895
61KDM2B_26808549_Chip-Seq_K562_Human1.29458040
62PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26889230
63GATA1_19941826_ChIP-Seq_K562_Human1.26184277
64PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26162610
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24723985
66MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.23831534
67* RACK7_27058665_Chip-Seq_MCF-7_Human1.22730613
68* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21688075
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21501210
70* DROSHA_22980978_ChIP-Seq_HELA_Human1.16238115
71* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14625280
72PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14316391
73LXR_22292898_ChIP-Seq_THP-1_Human1.14257758
74CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12887457
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12288114
76* RUNX1_27514584_Chip-Seq_MCF-7_Human1.06805258
77* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06555913
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06325481
79GATA2_19941826_ChIP-Seq_K562_Human1.02082741
80* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01010525
81CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99794703
82GATA3_26560356_Chip-Seq_TH2_Human0.99222988
83RARB_27405468_Chip-Seq_BRAIN_Mouse0.99218770
84VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97962471
85GATA2_21666600_ChIP-Seq_HMVEC_Human0.97917025
86ESR1_21235772_ChIP-Seq_MCF-7_Human0.97885091
87ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94749794
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92993977
89RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.91447935
90MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90951292
91CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90830151
92GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90056661
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89907621
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88404031
95* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.86179069
96LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.85540925
97SMRT_27268052_Chip-Seq_Bcells_Human0.84671245
98* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84345625
99GATA2_22383799_ChIP-Seq_G1ME_Mouse0.83082974
100DNAJC2_21179169_ChIP-ChIP_NT2_Human0.80678802
101GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80276205
102FOXO3_23340844_ChIP-Seq_DLD1_Human0.80082359
103GATA1_22025678_ChIP-Seq_K562_Human0.79255331
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.79182977
105* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78995860
106* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.75080157
107SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.73418401
108CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72332235
109AR_21572438_ChIP-Seq_LNCaP_Human0.72247668
110SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.71574423
111CTCF_27219007_Chip-Seq_ERYTHROID_Human0.71176712
112KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.70122824
113NFIB_24661679_ChIP-Seq_LUNG_Mouse0.69807838
114* NCOR1_26117541_ChIP-Seq_K562_Human0.67523759
115EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.67178923

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.92861542
2MP0005671_abnormal_response_to3.38691992
3MP0004510_myositis3.37148111
4MP0003303_peritoneal_inflammation3.27884857
5MP0000685_abnormal_immune_system3.25002220
6MP0005387_immune_system_phenotype2.99015906
7MP0001790_abnormal_immune_system2.99015906
8MP0001800_abnormal_humoral_immune2.90613146
9MP0005000_abnormal_immune_tolerance2.81379916
10MP0002452_abnormal_antigen_presenting2.68273943
11MP0002723_abnormal_immune_serum2.61562205
12MP0003436_decreased_susceptibility_to2.61086421
13MP0008260_abnormal_autophagy2.53735971
14* MP0002420_abnormal_adaptive_immunity2.53394183
15* MP0001819_abnormal_immune_cell2.53343675
16MP0006082_CNS_inflammation2.51152545
17* MP0002419_abnormal_innate_immunity2.48717129
18MP0003763_abnormal_thymus_physiology2.46399290
19MP0000569_abnormal_digit_pigmentation2.41483507
20MP0003300_gastrointestinal_ulcer2.37366571
21MP0002166_altered_tumor_susceptibility2.32596960
22MP0009785_altered_susceptibility_to2.31246651
23MP0002148_abnormal_hypersensitivity_rea2.30917989
24MP0005025_abnormal_response_to2.30146618
25MP0003172_abnormal_lysosome_physiology2.25110143
26MP0002398_abnormal_bone_marrow2.17828730
27MP0004381_abnormal_hair_follicle2.08600432
28* MP0000716_abnormal_immune_system2.03668993
29MP0005464_abnormal_platelet_physiology2.02186695
30MP0002006_tumorigenesis1.99670650
31MP0004859_abnormal_synaptic_plasticity1.97617679
32MP0005058_abnormal_lysosome_morphology1.94694322
33MP0002405_respiratory_system_inflammati1.92786066
34MP0001873_stomach_inflammation1.90911611
35MP0009278_abnormal_bone_marrow1.90185708
36MP0005310_abnormal_salivary_gland1.89326523
37MP0005451_abnormal_body_composition1.81694685
38MP0004947_skin_inflammation1.81475886
39MP0003828_pulmonary_edema1.74408812
40MP0002722_abnormal_immune_system1.66934067
41MP0000689_abnormal_spleen_morphology1.66407377
42MP0010155_abnormal_intestine_physiology1.59566162
43* MP0002429_abnormal_blood_cell1.58687473
44MP0000703_abnormal_thymus_morphology1.58545009
45MP0002396_abnormal_hematopoietic_system1.51191185
46MP0003183_abnormal_peptide_metabolism1.50678825
47MP0001845_abnormal_inflammatory_respons1.48519375
48MP0004883_abnormal_blood_vessel1.47715789
49MP0003075_altered_response_to1.45906166
50MP0002254_reproductive_system_inflammat1.45555720
51MP0002138_abnormal_hepatobiliary_system1.41588552
52MP0003448_altered_tumor_morphology1.41529271
53MP0001533_abnormal_skeleton_physiology1.37878258
54MP0004808_abnormal_hematopoietic_stem1.37342925
55MP0003690_abnormal_glial_cell1.36831038
56MP0009333_abnormal_splenocyte_physiolog1.34674231
57MP0000604_amyloidosis1.34628900
58MP0001853_heart_inflammation1.32954065
59MP0005397_hematopoietic_system_phenotyp1.31662000
60MP0001545_abnormal_hematopoietic_system1.31662000
61MP0005174_abnormal_tail_pigmentation1.31428510
62MP0002998_abnormal_bone_remodeling1.30861627
63MP0003866_abnormal_defecation1.29426078
64MP0008961_abnormal_basal_metabolism1.26020795
65MP0002132_abnormal_respiratory_system1.25222714
66MP0005076_abnormal_cell_differentiation1.20766716
67MP0003724_increased_susceptibility_to1.13476424
68MP0005167_abnormal_blood-brain_barrier1.13282186
69MP0001851_eye_inflammation1.12563538
70MP0002933_joint_inflammation1.11466443
71MP0003705_abnormal_hypodermis_morpholog1.10798455
72MP0005075_abnormal_melanosome_morpholog1.09181759
73MP0003191_abnormal_cellular_cholesterol1.08253345
74MP0000465_gastrointestinal_hemorrhage1.07849042
75MP0000920_abnormal_myelination1.07204925
76MP0008469_abnormal_protein_level1.06677263
77MP0002009_preneoplasia1.05785286
78MP0003091_abnormal_cell_migration1.02093900
79MP0005166_decreased_susceptibility_to0.97579445
80MP0009840_abnormal_foam_cell0.97019252
81MP0000858_altered_metastatic_potential0.96305109
82MP0004858_abnormal_nervous_system0.93471679
83MP0004264_abnormal_extraembryonic_tissu0.88028276
84MP0005164_abnormal_response_to0.87016429
85MP0003045_fibrosis0.85959011
86MP0010307_abnormal_tumor_latency0.84779575
87MP0008569_lethality_at_weaning0.83605220
88MP0001348_abnormal_lacrimal_gland0.79913504
89MP0002064_seizures0.78851396
90MP0003453_abnormal_keratinocyte_physiol0.78419386
91MP0000015_abnormal_ear_pigmentation0.77592128
92MP0003635_abnormal_synaptic_transmissio0.75852192
93MP0005390_skeleton_phenotype0.75392451
94MP0005409_darkened_coat_color0.73615242
95MP0003633_abnormal_nervous_system0.72502191
96MP0004130_abnormal_muscle_cell0.71864128
97MP0009764_decreased_sensitivity_to0.70606433
98MP0000343_altered_response_to0.70119676
99MP0005248_abnormal_Harderian_gland0.67985938
100MP0003656_abnormal_erythrocyte_physiolo0.67671973
101MP0008874_decreased_physiological_sensi0.66596853
102MP0000249_abnormal_blood_vessel0.64455471
103MP0002332_abnormal_exercise_endurance0.64411237
104MP0005388_respiratory_system_phenotype0.62595905
105MP0002133_abnormal_respiratory_system0.62595905
106MP0005423_abnormal_somatic_nervous0.62527009
107MP0003795_abnormal_bone_structure0.62423520
108MP0010352_gastrointestinal_tract_polyps0.61997501
109MP0003329_amyloid_beta_deposits0.61781450
110MP0003787_abnormal_imprinting0.61433284
111MP0009763_increased_sensitivity_to0.60760522
112MP0003221_abnormal_cardiomyocyte_apopto0.60709153
113MP0009745_abnormal_behavioral_response0.59139490
114MP0002277_abnormal_respiratory_mucosa0.58672767
115MP0003566_abnormal_cell_adhesion0.57774570
116MP0003634_abnormal_glial_cell0.55490577
117MP0001663_abnormal_digestive_system0.53824374
118MP0000371_diluted_coat_color0.51520010
119MP0001501_abnormal_sleep_pattern0.50126072
120MP0000490_abnormal_crypts_of0.49673238
121MP0004185_abnormal_adipocyte_glucose0.49029081

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.71809723
2Eczematoid dermatitis (HP:0000976)4.59363701
3Recurrent bacterial skin infections (HP:0005406)4.39978803
4Recurrent fungal infections (HP:0002841)4.19633655
5Recurrent viral infections (HP:0004429)4.03568762
6Myositis (HP:0100614)3.87392216
7Chronic otitis media (HP:0000389)3.80275474
8Elevated erythrocyte sedimentation rate (HP:0003565)3.67630752
9Increased cerebral lipofuscin (HP:0011813)3.40259173
10T lymphocytopenia (HP:0005403)3.38822395
11Mediastinal lymphadenopathy (HP:0100721)3.34408870
12Abnormality of T cell number (HP:0011839)3.34206974
13Chronic mucocutaneous candidiasis (HP:0002728)3.31181171
14Recurrent cutaneous fungal infections (HP:0011370)3.31181171
15Abnormality of macrophages (HP:0004311)3.29370164
16Recurrent skin infections (HP:0001581)3.26275656
17Optic neuritis (HP:0100653)3.26270343
18Retrobulbar optic neuritis (HP:0100654)3.26270343
19Abnormal delayed hypersensitivity skin test (HP:0002963)3.19903387
20Orchitis (HP:0100796)3.19731984
21Nasal polyposis (HP:0100582)3.08962791
22Panhypogammaglobulinemia (HP:0003139)3.00476489
23Colitis (HP:0002583)3.00114536
24Inflammation of the large intestine (HP:0002037)2.94264379
25Cellulitis (HP:0100658)2.91625099
26Stomatitis (HP:0010280)2.91214524
27Vasculitis (HP:0002633)2.87328374
28Meningitis (HP:0001287)2.86930880
29Autoimmune thrombocytopenia (HP:0001973)2.86611289
30Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.85829781
31Spontaneous hematomas (HP:0007420)2.85083487
32Recurrent gram-negative bacterial infections (HP:0005420)2.84026949
33Gastrointestinal inflammation (HP:0004386)2.83557908
34Urticaria (HP:0001025)2.83053086
35Hematochezia (HP:0002573)2.81536921
36Increased neuronal autofluorescent lipopigment (HP:0002074)2.80593354
37Abnormality of the fingertips (HP:0001211)2.79407883
38Eosinophilia (HP:0001880)2.78321867
39Abnormality of the nasal mucosa (HP:0000433)2.77788906
40Increased IgE level (HP:0003212)2.77521518
41Obstructive lung disease (HP:0006536)2.74339973
42Chronic obstructive pulmonary disease (HP:0006510)2.74339973
43Leukocytosis (HP:0001974)2.71812613
44IgM deficiency (HP:0002850)2.69447353
45Recurrent bronchitis (HP:0002837)2.68201756
46Thyroiditis (HP:0100646)2.62783188
47Pulmonary infiltrates (HP:0002113)2.62640125
48Pulmonary embolism (HP:0002204)2.59900831
49Abnormality of liposaccharide metabolism (HP:0010968)2.59570821
50Abnormality of glycosphingolipid metabolism (HP:0004343)2.59570821
51Abnormality of glycolipid metabolism (HP:0010969)2.59570821
52Abnormality of T cells (HP:0002843)2.57422032
53Fatigue (HP:0012378)2.56362071
54Slow saccadic eye movements (HP:0000514)2.55820267
55Gingivitis (HP:0000230)2.54722737
56Agammaglobulinemia (HP:0004432)2.51682574
57Hypochromic anemia (HP:0001931)2.49727547
58Hemiplegia (HP:0002301)2.48560454
59Abnormality of eosinophils (HP:0001879)2.47836796
60Pustule (HP:0200039)2.45090703
61Arterial thrombosis (HP:0004420)2.44662197
62Amyloidosis (HP:0011034)2.40588517
63Systemic lupus erythematosus (HP:0002725)2.40135079
64Periodontitis (HP:0000704)2.38751064
65Epistaxis (HP:0000421)2.36673767
66Episodic fever (HP:0001954)2.32390829
67Hypochromic microcytic anemia (HP:0004840)2.30800067
68Hemoptysis (HP:0002105)2.28366181
69Supranuclear gaze palsy (HP:0000605)2.26782733
70Loss of speech (HP:0002371)2.25445747
71Chest pain (HP:0100749)2.24110301
72Viral hepatitis (HP:0006562)2.22439281
73Dysostosis multiplex (HP:0000943)2.21083305
74Sepsis (HP:0100806)2.20052144
75Granulocytopenia (HP:0001913)2.19360595
76Peritonitis (HP:0002586)2.17760552
77Disinhibition (HP:0000734)2.16097070
78Anorexia (HP:0002039)2.15974500
79Severe combined immunodeficiency (HP:0004430)2.15113965
80Verrucae (HP:0200043)2.14501327
81Papilloma (HP:0012740)2.14501327
82Abnormality of the endocardium (HP:0004306)2.14236874
83Abnormality of binocular vision (HP:0011514)2.09066517
84Diplopia (HP:0000651)2.09066517
85Subacute progressive viral hepatitis (HP:0006572)2.06650081
86Lymphopenia (HP:0001888)2.02912084
87Increased IgM level (HP:0003496)2.00869183
88Hypergammaglobulinemia (HP:0010702)2.00434085
89Interstitial pulmonary disease (HP:0006530)2.00364222
90Abnormality of the pleura (HP:0002103)1.98977254
91Abnormality of the peritoneum (HP:0002585)1.98922760
92Abnormality of cells of the lymphoid lineage (HP:0012140)1.98840155
93Vertigo (HP:0002321)1.98519556
94Keratoconjunctivitis sicca (HP:0001097)1.98237484
95Cerebral aneurysm (HP:0004944)1.96316903
96Combined immunodeficiency (HP:0005387)1.95396353
97Encephalitis (HP:0002383)1.93815644
98Chronic diarrhea (HP:0002028)1.93733658
99Papilledema (HP:0001085)1.92914722
100Gangrene (HP:0100758)1.92691566
101Hyperacusis (HP:0010780)1.91562272
102Microcytic anemia (HP:0001935)1.89697582
103Emphysema (HP:0002097)1.88304188
104Keratoconjunctivitis (HP:0001096)1.87059123
105Absent frontal sinuses (HP:0002688)1.86614113
106Metaphyseal cupping (HP:0003021)1.86017850
107Arterial tortuosity (HP:0005116)1.85687670
108Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.84882490
109Chronic sinusitis (HP:0011109)1.84170234
110Osteomyelitis (HP:0002754)1.83044006
111Abnormality of B cell number (HP:0010975)1.82504206
112B lymphocytopenia (HP:0010976)1.82504206
113Mutism (HP:0002300)1.82217423
114Gastrointestinal infarctions (HP:0005244)1.81713669
115Frequent falls (HP:0002359)1.80946348
116Gastrointestinal stroma tumor (HP:0100723)1.80923685
117Glomerulopathy (HP:0100820)1.80665781
118Micronodular cirrhosis (HP:0001413)1.80664054
119Abnormality of T cell physiology (HP:0011840)1.80541212
120Difficulty running (HP:0009046)1.79497782
121Restrictive lung disease (HP:0002091)1.79421481
122Skin ulcer (HP:0200042)1.78952451
123Prolonged bleeding time (HP:0003010)1.76074355
124Segmental peripheral demyelination/remyelination (HP:0003481)1.75911916
125Neuronal loss in central nervous system (HP:0002529)1.75666416
126Apathy (HP:0000741)1.75457460
127Basal ganglia calcification (HP:0002135)1.75192239
128Acne (HP:0001061)1.74660160
129Gingival bleeding (HP:0000225)1.73911976

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.05208506
2MAP3K132.96725381
3TYK22.94810518
4PRPF4B2.91696921
5RIPK42.82221496
6MAP3K142.72838834
7TXK2.48078470
8JAK32.43798339
9JAK12.42140168
10TBK12.22742197
11EPHB12.19053549
12BLK2.13781826
13IKBKE2.04514588
14FES2.02285960
15SIK21.96474007
16IRAK41.88152084
17CSF1R1.77191866
18ITK1.76335209
19MAP3K101.75149964
20TGFBR21.72880265
21STK101.71756764
22TRIB31.64674666
23IKBKB1.62886133
24KIT1.53650406
25ZAP701.53252914
26HCK1.52974834
27GRK61.51796231
28FGFR31.51453785
29CSK1.49127905
30CLK11.48741957
31SYK1.45488063
32FGFR41.41970782
33SIK11.41722990
34EEF2K1.41057135
35MAP3K31.37357455
36LCK1.27916366
37SMG11.24395820
38CHUK1.19730053
39BTK1.19184887
40JAK21.18481221
41MAP3K91.17667783
42MAP3K111.16328644
43TYRO31.15968117
44YES11.15145123
45IRAK31.09683612
46PTK61.01572456
47CAMK1G0.99050929
48PKN20.98642416
49PRKCH0.97496702
50ALK0.92908713
51KSR20.91465938
52BMPR20.91230169
53RIPK10.89532042
54CAMKK10.88757919
55MARK30.88051509
56CAMK1D0.86971376
57DMPK0.86497387
58TESK20.86308532
59PRKD20.84018692
60PRKCQ0.83947319
61RET0.82935965
62NEK60.81860855
63FGR0.79666303
64PDK10.79367236
65PKN10.77830941
66STK110.75035441
67SGK30.73820954
68NTRK20.73811965
69DAPK20.73582629
70LRRK20.73500670
71PDGFRB0.71565937
72LYN0.70039118
73CDC42BPA0.66986388
74TEC0.66431881
75MAP3K20.66190872
76TAOK30.66059764
77MATK0.65622122
78TAOK20.65156723
79EPHA30.64288164
80HIPK20.63365162
81MAP3K70.62315938
82TAOK10.62075479
83TNK20.60953802
84PIM10.60852998
85MAPK70.60538632
86SGK20.59877875
87MAP2K20.58831961
88CDK120.58225096
89RPS6KC10.55094714
90RPS6KL10.55094714
91FYN0.54972800
92PAK60.54407284
93ERN10.54225063
94NLK0.53379662
95RPS6KA20.53314704
96IRAK10.51641946
97DYRK1B0.50984713
98MAP3K60.48559397
99BMX0.48190484
100PDPK10.48169367
101PTK2B0.44348064
102MAPK120.44333935
103MAP2K30.43552164
104NEK90.43087501
105RPS6KA60.42816317
106CDK60.42411870
107PRKD10.42251150
108RAF10.41537342
109MAP2K40.40322092
110SIK30.40163985
111CDK50.39427496
112RPS6KA40.39403042
113EGFR0.39252327
114SCYL20.39213450
115MARK20.37782170
116MAP3K10.36300027
117STK380.35586819
118PRKAA20.35450066
119IRAK20.35375292
120CDK90.35057383
121SGK10.35027708
122MOS0.32423288
123ICK0.32193408
124ABL10.30598480
125MELK0.30214511
126MAPKAPK20.29886453
127SRC0.29066598
128KSR10.28564959

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.32652993
2B cell receptor signaling pathway_Homo sapiens_hsa046622.21579720
3Leishmaniasis_Homo sapiens_hsa051402.21028541
4Primary immunodeficiency_Homo sapiens_hsa053402.15945550
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.04499054
6Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.93865116
7T cell receptor signaling pathway_Homo sapiens_hsa046601.93124935
8NF-kappa B signaling pathway_Homo sapiens_hsa040641.92623602
9Measles_Homo sapiens_hsa051621.74553596
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.70987287
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.66493626
12* Chemokine signaling pathway_Homo sapiens_hsa040621.63111524
13Graft-versus-host disease_Homo sapiens_hsa053321.61126725
14Antigen processing and presentation_Homo sapiens_hsa046121.56962041
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.56425380
16Toxoplasmosis_Homo sapiens_hsa051451.49671499
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.46254155
18Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.44951942
19Allograft rejection_Homo sapiens_hsa053301.43836295
20Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.43728896
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.43404434
22Tuberculosis_Homo sapiens_hsa051521.39621914
23TNF signaling pathway_Homo sapiens_hsa046681.36708680
24Staphylococcus aureus infection_Homo sapiens_hsa051501.33655535
25Chronic myeloid leukemia_Homo sapiens_hsa052201.28360591
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28268096
27Neurotrophin signaling pathway_Homo sapiens_hsa047221.24877717
28Pertussis_Homo sapiens_hsa051331.24260408
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.24175590
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.21511782
31Acute myeloid leukemia_Homo sapiens_hsa052211.20791731
32Shigellosis_Homo sapiens_hsa051311.20460060
33Influenza A_Homo sapiens_hsa051641.19300365
34Viral myocarditis_Homo sapiens_hsa054161.19246772
35Apoptosis_Homo sapiens_hsa042101.19123043
36Pancreatic cancer_Homo sapiens_hsa052121.15910040
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.15461163
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11502065
39Hepatitis B_Homo sapiens_hsa051611.10209971
40Platelet activation_Homo sapiens_hsa046111.06311140
41Hematopoietic cell lineage_Homo sapiens_hsa046401.04983018
42Phagosome_Homo sapiens_hsa041451.04459446
43VEGF signaling pathway_Homo sapiens_hsa043701.02859522
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01834891
45Non-small cell lung cancer_Homo sapiens_hsa052230.99408432
46Salmonella infection_Homo sapiens_hsa051320.99230449
47Lysosome_Homo sapiens_hsa041420.99176633
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95552740
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95403728
50Type II diabetes mellitus_Homo sapiens_hsa049300.94718642
51Glycosaminoglycan degradation_Homo sapiens_hsa005310.94659385
52Herpes simplex infection_Homo sapiens_hsa051680.94115094
53Olfactory transduction_Homo sapiens_hsa047400.93714502
54Prolactin signaling pathway_Homo sapiens_hsa049170.93227844
55Endocytosis_Homo sapiens_hsa041440.90714279
56Malaria_Homo sapiens_hsa051440.89973298
57Colorectal cancer_Homo sapiens_hsa052100.89316731
58Dorso-ventral axis formation_Homo sapiens_hsa043200.89141516
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.85711661
60Glioma_Homo sapiens_hsa052140.84472096
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.84065150
62Legionellosis_Homo sapiens_hsa051340.82999153
63Renal cell carcinoma_Homo sapiens_hsa052110.82199407
64Type I diabetes mellitus_Homo sapiens_hsa049400.79847150
65MAPK signaling pathway_Homo sapiens_hsa040100.78653925
66Hepatitis C_Homo sapiens_hsa051600.78048389
67FoxO signaling pathway_Homo sapiens_hsa040680.77808448
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76936081
69Asthma_Homo sapiens_hsa053100.76570459
70Autoimmune thyroid disease_Homo sapiens_hsa053200.76157111
71HIF-1 signaling pathway_Homo sapiens_hsa040660.74941138
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74819041
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74179791
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74162002
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72449242
76Morphine addiction_Homo sapiens_hsa050320.71455484
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71346782
78Notch signaling pathway_Homo sapiens_hsa043300.71272912
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70497095
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69070382
81Long-term potentiation_Homo sapiens_hsa047200.68581647
82Rheumatoid arthritis_Homo sapiens_hsa053230.68360754
83Cholinergic synapse_Homo sapiens_hsa047250.68030100
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.68015497
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68009384
86Other glycan degradation_Homo sapiens_hsa005110.67809570
87Nitrogen metabolism_Homo sapiens_hsa009100.67281580
88Estrogen signaling pathway_Homo sapiens_hsa049150.67212339
89Gastric acid secretion_Homo sapiens_hsa049710.66962871
90Choline metabolism in cancer_Homo sapiens_hsa052310.65171396
91mTOR signaling pathway_Homo sapiens_hsa041500.64971390
92African trypanosomiasis_Homo sapiens_hsa051430.64721389
93Epstein-Barr virus infection_Homo sapiens_hsa051690.64160660
94ErbB signaling pathway_Homo sapiens_hsa040120.63910781
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63709848
96HTLV-I infection_Homo sapiens_hsa051660.63666542
97Insulin resistance_Homo sapiens_hsa049310.63595703
98Prostate cancer_Homo sapiens_hsa052150.63433219
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63366319
100Glutamatergic synapse_Homo sapiens_hsa047240.63268849
101Viral carcinogenesis_Homo sapiens_hsa052030.63119723
102Oxytocin signaling pathway_Homo sapiens_hsa049210.63020182
103Salivary secretion_Homo sapiens_hsa049700.62409732
104Amoebiasis_Homo sapiens_hsa051460.61804774
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61276789
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61003355
107Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60886821
108Endometrial cancer_Homo sapiens_hsa052130.60655289
109Rap1 signaling pathway_Homo sapiens_hsa040150.59961517
110Renin secretion_Homo sapiens_hsa049240.59639793
111Inositol phosphate metabolism_Homo sapiens_hsa005620.59277781
112Small cell lung cancer_Homo sapiens_hsa052220.58265969
113GnRH signaling pathway_Homo sapiens_hsa049120.58013416
114Insulin signaling pathway_Homo sapiens_hsa049100.56200406
115Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55427830
116Thyroid cancer_Homo sapiens_hsa052160.54288664

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