PRF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to interleukin-15 (GO:0071350)9.71264061
2regulation of natural killer cell mediated cytotoxicity (GO:0042269)9.56886235
3regulation of natural killer cell mediated immunity (GO:0002715)9.56886235
4response to interleukin-15 (GO:0070672)8.41195996
5activated T cell proliferation (GO:0050798)8.03284317
6* cytolysis (GO:0019835)7.83558394
7negative regulation of cell killing (GO:0031342)6.82619162
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.82619162
9positive regulation of gamma-delta T cell activation (GO:0046645)6.55134792
10regulation of isotype switching to IgG isotypes (GO:0048302)6.41868541
11regulation of leukocyte mediated cytotoxicity (GO:0001910)6.33051241
12* cellular defense response (GO:0006968)6.32101814
13natural killer cell activation (GO:0030101)6.30958319
14positive regulation of natural killer cell mediated immunity (GO:0002717)6.30318872
15positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)6.30318872
16negative thymic T cell selection (GO:0045060)6.28013812
17negative T cell selection (GO:0043383)6.25378322
18positive thymic T cell selection (GO:0045059)5.93248494
19regulation of cell killing (GO:0031341)5.66916995
20positive regulation of isotype switching (GO:0045830)5.58798327
21T cell migration (GO:0072678)5.34827753
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.26960119
23antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.26960119
24regulation of gamma-delta T cell differentiation (GO:0045586)5.20628921
25thymic T cell selection (GO:0045061)5.15866827
26positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)5.08269481
27positive T cell selection (GO:0043368)5.00512521
28positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.96502028
29cytidine deamination (GO:0009972)4.92425475
30cytidine metabolic process (GO:0046087)4.92425475
31cytidine catabolic process (GO:0006216)4.92425475
32positive regulation of DNA recombination (GO:0045911)4.75190232
33positive regulation of immunoglobulin mediated immune response (GO:0002891)4.73598797
34positive regulation of B cell mediated immunity (GO:0002714)4.73598797
35positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.68773266
36regulation of gamma-delta T cell activation (GO:0046643)4.62691283
37positive regulation of cell killing (GO:0031343)4.54890545
38pyrimidine ribonucleoside catabolic process (GO:0046133)4.53012493
39antigen processing and presentation via MHC class Ib (GO:0002475)4.43727362
40antigen processing and presentation of endogenous antigen (GO:0019883)4.36289765
41negative regulation of T cell mediated immunity (GO:0002710)4.25852743
42T cell selection (GO:0045058)4.24646584
43negative regulation of leukocyte mediated immunity (GO:0002704)4.13682833
44regulation of B cell receptor signaling pathway (GO:0050855)4.12293661
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.07453536
46regulation of lymphocyte mediated immunity (GO:0002706)4.05655543
47regulation of T cell mediated cytotoxicity (GO:0001914)4.05624214
48neutrophil activation involved in immune response (GO:0002283)4.01651907
49regulation of regulatory T cell differentiation (GO:0045589)4.00317981
50regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.00194501
51leukocyte aggregation (GO:0070486)3.97422657
52substrate-dependent cell migration (GO:0006929)3.97402439
53regulation of T cell tolerance induction (GO:0002664)3.97343837
54heterotypic cell-cell adhesion (GO:0034113)3.95198442
55positive regulation of B cell differentiation (GO:0045579)3.94297710
56regulation of isotype switching (GO:0045191)3.91582028
57regulation of hypersensitivity (GO:0002883)3.88186994
58lymphocyte migration (GO:0072676)3.87282177
59neutrophil activation (GO:0042119)3.85380633
60leukocyte cell-cell adhesion (GO:0007159)3.84769331
61regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.84191500
62regulation of response to interferon-gamma (GO:0060330)3.82274414
63positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.79878903
64sequestering of actin monomers (GO:0042989)3.79197321
65T cell costimulation (GO:0031295)3.77975262
66regulation of tolerance induction (GO:0002643)3.77076231
67positive regulation of alpha-beta T cell proliferation (GO:0046641)3.76549137
68regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.75175821
69granulocyte activation (GO:0036230)3.73650972
70positive regulation of lymphocyte mediated immunity (GO:0002708)3.71488311
71DNA deamination (GO:0045006)3.70321436
72T cell receptor signaling pathway (GO:0050852)3.70317733
73T cell differentiation involved in immune response (GO:0002292)3.69942277
74alpha-beta T cell differentiation involved in immune response (GO:0002293)3.69942277
75alpha-beta T cell activation involved in immune response (GO:0002287)3.69942277
76lymphocyte costimulation (GO:0031294)3.69046725
77positive regulation of humoral immune response (GO:0002922)3.68697354
78T cell proliferation (GO:0042098)3.68271505
79regulation of alpha-beta T cell proliferation (GO:0046640)3.66131450
80detection of bacterium (GO:0016045)3.64932711
81macrophage activation involved in immune response (GO:0002281)3.64773962
82regulation of immunoglobulin mediated immune response (GO:0002889)3.62529101
83regulation of lymphocyte chemotaxis (GO:1901623)3.62037769
84positive regulation by symbiont of host defense response (GO:0052509)3.61689726
85modulation by symbiont of host defense response (GO:0052031)3.61689726
86modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.61689726
87modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.61689726
88positive regulation by organism of defense response of other organism involved in symbiotic interact3.61689726
89modulation by symbiont of host immune response (GO:0052553)3.61689726
90cellular response to type I interferon (GO:0071357)3.61095419
91type I interferon signaling pathway (GO:0060337)3.61095419
92detection of other organism (GO:0098543)3.59429680
93response to type I interferon (GO:0034340)3.58048021
94alpha-beta T cell activation (GO:0046631)3.56993910
95dendritic cell chemotaxis (GO:0002407)3.54593402
96negative regulation of interleukin-12 production (GO:0032695)3.54488255
97cellular extravasation (GO:0045123)3.54362449
98regulation of activation of Janus kinase activity (GO:0010533)3.49924504
99regulation of B cell mediated immunity (GO:0002712)3.49775102
100B cell receptor signaling pathway (GO:0050853)3.48703958
101regulation of chemokine-mediated signaling pathway (GO:0070099)3.48295245
102hypotonic response (GO:0006971)3.46421311
103alpha-beta T cell differentiation (GO:0046632)3.45993301
104positive regulation of immunoglobulin production (GO:0002639)3.44735086
105skin morphogenesis (GO:0043589)3.42629101
106regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.40856028
107T cell activation involved in immune response (GO:0002286)3.39620044
108response to protozoan (GO:0001562)3.37605861
109immunoglobulin mediated immune response (GO:0016064)3.35349350
110negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.33991940
111respiratory burst (GO:0045730)3.32213799
112positive regulation of interferon-gamma production (GO:0032729)3.32138409
113myeloid cell activation involved in immune response (GO:0002275)3.31267094
114regulation of leukocyte mediated immunity (GO:0002703)3.28609507
115dendritic cell migration (GO:0036336)3.27685791
116negative regulation of phagocytosis (GO:0050765)3.25521347
117lymphocyte chemotaxis (GO:0048247)3.24832408
118positive regulation of tolerance induction (GO:0002645)3.23887645
119antigen receptor-mediated signaling pathway (GO:0050851)3.19866430
120citrulline biosynthetic process (GO:0019240)3.19371582
121negative regulation of leukocyte chemotaxis (GO:0002689)3.18310598
122positive regulation of leukocyte mediated immunity (GO:0002705)3.17008868
123leukocyte degranulation (GO:0043299)3.14783016
124regulation of B cell differentiation (GO:0045577)3.13877765
125regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.13580137
126regulation of interleukin-2 biosynthetic process (GO:0045076)3.12141484
127T cell differentiation (GO:0030217)3.11083503
128negative regulation of viral genome replication (GO:0045071)3.10586906
129regulation of response to tumor cell (GO:0002834)3.09869394
130positive regulation of response to tumor cell (GO:0002836)3.09869394
131positive regulation of immune response to tumor cell (GO:0002839)3.09869394
132regulation of immune response to tumor cell (GO:0002837)3.09869394
133negative regulation of lymphocyte mediated immunity (GO:0002707)3.08649642
134positive regulation of T cell mediated cytotoxicity (GO:0001916)3.08536131
135positive regulation of calcium-mediated signaling (GO:0050850)3.07695617
136regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.07386999
137negative regulation of innate immune response (GO:0045824)3.06142906
138positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.05777952
139negative regulation of B cell proliferation (GO:0030889)3.05161041
140negative regulation of alpha-beta T cell activation (GO:0046636)3.03107199
141negative regulation of T cell apoptotic process (GO:0070233)3.03031597
142mast cell activation (GO:0045576)2.93680960
143negative regulation of oxidoreductase activity (GO:0051354)2.91197362
144T cell activation (GO:0042110)2.90906142
145regulation of alkaline phosphatase activity (GO:0010692)2.85804278
146sarcoplasmic reticulum calcium ion transport (GO:0070296)2.84880600
147interferon-gamma production (GO:0032609)13.4731274

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.80558321
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.53430459
3STAT3_20064451_ChIP-Seq_CD4+T_Mouse5.23245253
4STAT4_19710469_ChIP-ChIP_TH1__Mouse4.65855647
5* RUNX_20019798_ChIP-Seq_JUKART_Human3.76379304
6MYB_26560356_Chip-Seq_TH2_Human3.65794506
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.65328568
8FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.58004218
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.27428866
10MYB_26560356_Chip-Seq_TH1_Human3.09239284
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.04943173
12MAF_26560356_Chip-Seq_TH1_Human3.00908755
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.98050590
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.84329752
15* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.74998340
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.71542403
17UTX_26944678_Chip-Seq_JUKART_Human2.71232603
18MYC_22102868_ChIP-Seq_BL_Human2.62935039
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.42093586
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.32577040
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.16736280
22GATA3_27048872_Chip-Seq_THYMUS_Human2.16117675
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.15691817
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.14977301
25MYB_21317192_ChIP-Seq_ERMYB_Mouse2.12886561
26RUNX1_22412390_ChIP-Seq_EML_Mouse2.10615576
27TCF7_22412390_ChIP-Seq_EML_Mouse2.08712078
28VDR_21846776_ChIP-Seq_THP-1_Human2.06770076
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.01015958
30E2F7_22180533_ChIP-Seq_HELA_Human1.99883544
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.95419324
32* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.92962019
33SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92394848
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.90913155
35KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.90191509
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.87043881
37MAF_26560356_Chip-Seq_TH2_Human1.83124640
38KDM2B_26808549_Chip-Seq_DND41_Human1.82529421
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82261399
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79043365
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.77401161
42SPI1_23547873_ChIP-Seq_NB4_Human1.75030072
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73745947
44RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.73428274
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.66573184
46VDR_24763502_ChIP-Seq_THP-1_Human1.62575997
47SPI1_23127762_ChIP-Seq_K562_Human1.57997936
48CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.55432143
49BP1_19119308_ChIP-ChIP_Hs578T_Human1.55151695
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54630148
51* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53063454
52SCL_19346495_ChIP-Seq_HPC-7_Human1.41827366
53GATA3_26560356_Chip-Seq_TH2_Human1.37400758
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.34322930
55KDM2B_26808549_Chip-Seq_JURKAT_Human1.29783447
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.29251536
57* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26843554
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26836139
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24777519
60BCL6_27268052_Chip-Seq_Bcells_Human1.20195708
61* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17553121
62VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.16211722
63TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15827003
64VDR_24787735_ChIP-Seq_THP-1_Human1.15300530
65CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15006404
66PU_27001747_Chip-Seq_BMDM_Mouse1.14179122
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08949969
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07958536
69LXR_22292898_ChIP-Seq_THP-1_Human1.05040515
70FOXO3_23340844_ChIP-Seq_DLD1_Human1.03174424
71GATA2_19941826_ChIP-Seq_K562_Human1.00819829
72GATA1_19941826_ChIP-Seq_K562_Human1.00394037
73NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00385413
74* NCOR1_26117541_ChIP-Seq_K562_Human0.99661930
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98885223
76PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98587851
77GATA2_21666600_ChIP-Seq_HMVEC_Human0.98442404
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97729640
79BCOR_27268052_Chip-Seq_Bcells_Human0.96540480
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96206654
81CIITA_25753668_ChIP-Seq_RAJI_Human0.94178114
82IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93485895
83CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92222956
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92202318
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91647020
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90050295
87* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86228802
88ELF1_20517297_ChIP-Seq_JURKAT_Human0.85456826
89RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84983844
90GATA3_26560356_Chip-Seq_TH1_Human0.82833045
91EGR1_19032775_ChIP-ChIP_M12_Human0.82826818
92TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.82383108
93SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.82336769
94SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.82336769
95* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81645186
96FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81435301
97ELF1_17652178_ChIP-ChIP_JURKAT_Human0.81054516
98CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80378120
99SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.79807672
100GATA1_22025678_ChIP-Seq_K562_Human0.78870095
101EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.78043312
102* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77516959
103PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77402603
104SA1_27219007_Chip-Seq_Bcells_Human0.76844655
105HOXB4_20404135_ChIP-ChIP_EML_Mouse0.76313111
106SPI1_20517297_ChIP-Seq_HL60_Human0.76190113
107P300_27268052_Chip-Seq_Bcells_Human0.76072673
108RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.75779847
109GATA1_22383799_ChIP-Seq_G1ME_Mouse0.75685704
110CTCF_27219007_Chip-Seq_ERYTHROID_Human0.75427918
111Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.73859784
112GATA1_19941827_ChIP-Seq_MEL_Mouse0.73190339
113PU.1_20513432_ChIP-Seq_Bcells_Mouse0.72296282
114PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.71661916
115CLOCK_20551151_ChIP-Seq_293T_Human0.71553365
116SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.70313499
117ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.67428767
118* SA1_27219007_Chip-Seq_ERYTHROID_Human0.67302448
119FLI1_21867929_ChIP-Seq_CD8_Mouse0.65914336
120SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.65435097
121EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.64541015

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005671_abnormal_response_to6.91965494
2* MP0006082_CNS_inflammation4.02642048
3MP0009785_altered_susceptibility_to3.68656636
4MP0003763_abnormal_thymus_physiology3.60350088
5MP0003950_abnormal_plasma_membrane3.33234391
6* MP0003448_altered_tumor_morphology3.20096076
7* MP0001800_abnormal_humoral_immune3.17850821
8* MP0005025_abnormal_response_to3.13395492
9MP0000858_altered_metastatic_potential3.07838264
10* MP0002420_abnormal_adaptive_immunity3.04541168
11* MP0001819_abnormal_immune_cell3.00363351
12MP0009333_abnormal_splenocyte_physiolog2.88248433
13* MP0002723_abnormal_immune_serum2.83285680
14MP0005387_immune_system_phenotype2.82178036
15MP0001790_abnormal_immune_system2.82178036
16MP0002132_abnormal_respiratory_system2.56716279
17* MP0005000_abnormal_immune_tolerance2.56300563
18MP0000685_abnormal_immune_system2.50108427
19MP0001873_stomach_inflammation2.47506825
20* MP0002452_abnormal_antigen_presenting2.47465666
21* MP0002398_abnormal_bone_marrow2.41866544
22MP0002006_tumorigenesis2.30321147
23* MP0000716_abnormal_immune_system2.27406595
24MP0003300_gastrointestinal_ulcer2.24227555
25MP0010155_abnormal_intestine_physiology2.13307263
26MP0002405_respiratory_system_inflammati2.12736124
27* MP0001835_abnormal_antigen_presentation2.04486013
28MP0002166_altered_tumor_susceptibility2.01411454
29MP0002148_abnormal_hypersensitivity_rea2.00962050
30* MP0002722_abnormal_immune_system2.00571690
31* MP0000703_abnormal_thymus_morphology1.97338972
32MP0002419_abnormal_innate_immunity1.95981383
33MP0005464_abnormal_platelet_physiology1.94087556
34MP0003724_increased_susceptibility_to1.89300659
35* MP0000689_abnormal_spleen_morphology1.84515159
36MP0004947_skin_inflammation1.84446292
37MP0003866_abnormal_defecation1.82647794
38* MP0002429_abnormal_blood_cell1.81453824
39* MP0001845_abnormal_inflammatory_respons1.71768215
40MP0003436_decreased_susceptibility_to1.70758552
41MP0004510_myositis1.60509210
42MP0001851_eye_inflammation1.57248419
43* MP0008469_abnormal_protein_level1.43836485
44MP0003690_abnormal_glial_cell1.40756613
45MP0002933_joint_inflammation1.36293544
46MP0002998_abnormal_bone_remodeling1.30050299
47MP0005166_decreased_susceptibility_to1.27966001
48MP0000343_altered_response_to1.26384753
49MP0002254_reproductive_system_inflammat1.25731522
50MP0002396_abnormal_hematopoietic_system1.25461918
51MP0002277_abnormal_respiratory_mucosa1.24649732
52MP0003172_abnormal_lysosome_physiology1.24265761
53MP0005310_abnormal_salivary_gland1.17146437
54MP0000604_amyloidosis1.16118782
55MP0001533_abnormal_skeleton_physiology1.14340961
56MP0006054_spinal_hemorrhage1.10230022
57* MP0009763_increased_sensitivity_to1.09120322
58MP0003566_abnormal_cell_adhesion1.08674625
59MP0000490_abnormal_crypts_of1.07567020
60MP0003303_peritoneal_inflammation1.07303425
61MP0003183_abnormal_peptide_metabolism1.07170080
62MP0005075_abnormal_melanosome_morpholog1.05256402
63* MP0002019_abnormal_tumor_incidence1.04473167
64MP0010352_gastrointestinal_tract_polyps1.01819309
65MP0004808_abnormal_hematopoietic_stem0.94760373
66MP0000613_abnormal_salivary_gland0.92230244
67MP0001986_abnormal_taste_sensitivity0.91091011
68MP0004883_abnormal_blood_vessel0.90430672
69MP0003045_fibrosis0.88867140
70MP0008260_abnormal_autophagy0.86493471
71MP0003329_amyloid_beta_deposits0.84541906
72MP0005023_abnormal_wound_healing0.81508163
73MP0003075_altered_response_to0.80873937
74MP0000465_gastrointestinal_hemorrhage0.79663285
75MP0000609_abnormal_liver_physiology0.78327331
76MP0008438_abnormal_cutaneous_collagen0.78177547
77MP0004130_abnormal_muscle_cell0.77285242
78MP0003279_aneurysm0.75989662
79MP0003828_pulmonary_edema0.74348340
80MP0005451_abnormal_body_composition0.72038571
81MP0005584_abnormal_enzyme/coenzyme_acti0.71163331
82MP0004381_abnormal_hair_follicle0.68541283
83MP0005397_hematopoietic_system_phenotyp0.66612128
84MP0001545_abnormal_hematopoietic_system0.66612128
85MP0000249_abnormal_blood_vessel0.65224994
86MP0003091_abnormal_cell_migration0.63447588
87MP0009765_abnormal_xenobiotic_induced0.62915200
88* MP0000920_abnormal_myelination0.62751758
89MP0001853_heart_inflammation0.58908373
90MP0002163_abnormal_gland_morphology0.57946381
91MP0002136_abnormal_kidney_physiology0.54034672
92MP0003943_abnormal_hepatobiliary_system0.53765514
93* MP0008873_increased_physiological_sensi0.53730928
94* MP0002693_abnormal_pancreas_physiology0.53626484
95MP0001348_abnormal_lacrimal_gland0.52489712
96MP0003795_abnormal_bone_structure0.51227103
97MP0005377_hearing/vestibular/ear_phenot0.50970991
98MP0003878_abnormal_ear_physiology0.50970991
99MP0009384_cardiac_valve_regurgitation0.50611418
100MP0001958_emphysema0.48605367
101MP0002086_abnormal_extraembryonic_tissu0.48178173
102MP0003191_abnormal_cellular_cholesterol0.47569705
103MP0005058_abnormal_lysosome_morphology0.47440059
104MP0003453_abnormal_keratinocyte_physiol0.47197826
105MP0008874_decreased_physiological_sensi0.46366786
106MP0000367_abnormal_coat/_hair0.43903946
107MP0008961_abnormal_basal_metabolism0.43234169
108MP0001663_abnormal_digestive_system0.43000643
109MP0004142_abnormal_muscle_tone0.42580231
110MP0009764_decreased_sensitivity_to0.41582789
111MP0000477_abnormal_intestine_morphology0.41231029
112MP0005164_abnormal_response_to0.40980809
113MP0005381_digestive/alimentary_phenotyp0.40895620
114MP0002009_preneoplasia0.40517448
115MP0009278_abnormal_bone_marrow0.39614923
116MP0003890_abnormal_embryonic-extraembry0.39271585
117MP0001919_abnormal_reproductive_system0.38941989
118* MP0002083_premature_death0.37713047
119MP0005390_skeleton_phenotype0.37528679
120MP0001765_abnormal_ion_homeostasis0.37046761
121MP0001915_intracranial_hemorrhage0.36130869
122MP0002138_abnormal_hepatobiliary_system0.35996228
123* MP0009642_abnormal_blood_homeostasis0.35791642
124MP0000015_abnormal_ear_pigmentation0.35461768
125MP0002168_other_aberrant_phenotype0.35289350
126MP0000470_abnormal_stomach_morphology0.32227647
127MP0005083_abnormal_biliary_tract0.31392725

Predicted human phenotypes

RankGene SetZ-score
1Nasal polyposis (HP:0100582)6.94672877
2T lymphocytopenia (HP:0005403)6.09318045
3Joint swelling (HP:0001386)5.84992328
4Abnormality of the nasal mucosa (HP:0000433)5.79968456
5Abnormality of T cell number (HP:0011839)5.76692305
6Myositis (HP:0100614)5.62339293
7Retrobulbar optic neuritis (HP:0100654)5.56705819
8Optic neuritis (HP:0100653)5.56705819
9Recurrent bacterial skin infections (HP:0005406)5.09394048
10Orchitis (HP:0100796)5.06133530
11Increased IgM level (HP:0003496)4.59291730
12Recurrent gram-negative bacterial infections (HP:0005420)4.09957531
13Keratoconjunctivitis sicca (HP:0001097)4.07560877
14* Abnormality of macrophages (HP:0004311)3.98893521
15Spontaneous hematomas (HP:0007420)3.98700531
16Autoimmune hemolytic anemia (HP:0001890)3.96729321
17Increased density of long bones (HP:0006392)3.88082447
18Recurrent skin infections (HP:0001581)3.79629665
19Abnormality of T cells (HP:0002843)3.71525875
20Keratoconjunctivitis (HP:0001096)3.68193111
21Bilateral sensorineural hearing impairment (HP:0008619)3.66587806
22Recurrent bronchitis (HP:0002837)3.63826419
23Chronic otitis media (HP:0000389)3.50958452
24* Encephalitis (HP:0002383)3.43621057
25Abnormality of T cell physiology (HP:0011840)3.42760609
26Arterial thrombosis (HP:0004420)3.31137476
27Elevated erythrocyte sedimentation rate (HP:0003565)3.27786815
28Pulmonary embolism (HP:0002204)3.26642180
29Increased IgE level (HP:0003212)3.22608311
30Aortic dissection (HP:0002647)3.16307081
31Inflammation of the large intestine (HP:0002037)3.14884437
32Eczematoid dermatitis (HP:0000976)3.12654474
33IgM deficiency (HP:0002850)3.12452538
34Hypochromic anemia (HP:0001931)3.12050209
35Aortic aneurysm (HP:0004942)3.11988312
36Spondylolisthesis (HP:0003302)3.06368672
37Recurrent abscess formation (HP:0002722)3.04918391
38Gingivitis (HP:0000230)3.00860210
39Gastrointestinal inflammation (HP:0004386)3.00375575
40Abnormality of cells of the lymphoid lineage (HP:0012140)2.98979950
41Recurrent viral infections (HP:0004429)2.98685446
42Chronic diarrhea (HP:0002028)2.97658113
43Agammaglobulinemia (HP:0004432)2.96718858
44Pulmonary infiltrates (HP:0002113)2.94094093
45Absent frontal sinuses (HP:0002688)2.92462502
46Recurrent fungal infections (HP:0002841)2.91146842
47Vasculitis (HP:0002633)2.89639362
48Gingival bleeding (HP:0000225)2.83911490
49Abnormal delayed hypersensitivity skin test (HP:0002963)2.82387172
50Urticaria (HP:0001025)2.81916138
51Arterial tortuosity (HP:0005116)2.80338919
52* Meningitis (HP:0001287)2.79984875
53Hemoptysis (HP:0002105)2.77486163
54Eosinophilia (HP:0001880)2.77129816
55Pustule (HP:0200039)2.73150596
56Abnormality of binocular vision (HP:0011514)2.69559690
57Diplopia (HP:0000651)2.69559690
58Abnormal platelet volume (HP:0011876)2.67438558
59Purpura (HP:0000979)2.62413031
60Severe combined immunodeficiency (HP:0004430)2.60449625
61Prolonged bleeding time (HP:0003010)2.55720473
62Leukocytosis (HP:0001974)2.54738113
63Combined immunodeficiency (HP:0005387)2.54482930
64Abnormality of eosinophils (HP:0001879)2.54394418
65Anorexia (HP:0002039)2.51733833
66Periodontitis (HP:0000704)2.50717428
67Petechiae (HP:0000967)2.49570914
68Bicuspid aortic valve (HP:0001647)2.46572156
69Vascular tortuosity (HP:0004948)2.44227820
70Epistaxis (HP:0000421)2.44099812
71Acute hepatic failure (HP:0006554)2.42837166
72Abnormality of the fingertips (HP:0001211)2.42666257
73Chronic obstructive pulmonary disease (HP:0006510)2.40391275
74Obstructive lung disease (HP:0006536)2.40391275
75Abnormality of the pleura (HP:0002103)2.40125977
76Chronic sinusitis (HP:0011109)2.38736944
77Episodic fever (HP:0001954)2.37848046
78Osteolytic defects of the hand bones (HP:0009699)2.37178362
79Osteolytic defects of the phalanges of the hand (HP:0009771)2.37178362
80Gastrointestinal infarctions (HP:0005244)2.33977068
81Hypochromic microcytic anemia (HP:0004840)2.33083285
82Abnormality of oral frenula (HP:0000190)2.30006189
83Chest pain (HP:0100749)2.29828265
84Ureteral stenosis (HP:0000071)2.28812138
85Granulocytopenia (HP:0001913)2.27963456
86Persistence of primary teeth (HP:0006335)2.27279070
87Panhypogammaglobulinemia (HP:0003139)2.27228801
88Hypoplasia of the thymus (HP:0000778)2.27010234
89Stomatitis (HP:0010280)2.26716890
90Gangrene (HP:0100758)2.26047322
91Arthralgia (HP:0002829)2.24209592
92Impaired platelet aggregation (HP:0003540)2.22656539
93Abnormal platelet function (HP:0011869)2.22656539
94Dilatation of the ascending aorta (HP:0005111)2.19474009
95Delayed closure of the anterior fontanelle (HP:0001476)2.17862765
96Striae distensae (HP:0001065)2.17713965
97Colitis (HP:0002583)2.16816704
98Microcytic anemia (HP:0001935)2.16407379
99Menorrhagia (HP:0000132)2.16311487
100Cellulitis (HP:0100658)2.16236369
101Increased mean platelet volume (HP:0011877)2.15797569
102Mediastinal lymphadenopathy (HP:0100721)2.13211462
103Dysostosis multiplex (HP:0000943)2.13147340
104Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.09433007
105Aplastic anemia (HP:0001915)2.09373644
106Autoimmune thrombocytopenia (HP:0001973)2.07973143
107Ureteral obstruction (HP:0006000)2.07960978
108Cerebral aneurysm (HP:0004944)2.06244373
109Hypergammaglobulinemia (HP:0010702)2.05734620
110Verrucae (HP:0200043)2.04805199
111Papilloma (HP:0012740)2.04805199
112Sepsis (HP:0100806)2.04427187
113Deep philtrum (HP:0002002)2.02225591
114Broad ribs (HP:0000885)2.01708457
115Bronchitis (HP:0012387)1.99085205
116Glomerulopathy (HP:0100820)1.98747278
117Thyroiditis (HP:0100646)1.98690709
118Interstitial pulmonary disease (HP:0006530)1.96051329
119Skin ulcer (HP:0200042)1.94382808
120Acne (HP:0001061)1.94281102
121Skin rash (HP:0000988)1.93572716
122Lymphopenia (HP:0001888)1.92752277
123Alveolar cell carcinoma (HP:0006519)1.92560237
124Abnormality of the prostate (HP:0008775)1.91556931
125Keratitis (HP:0000491)1.91309954
126Recurrent cutaneous fungal infections (HP:0011370)1.90642525
127Chronic mucocutaneous candidiasis (HP:0002728)1.90642525
128Amaurosis fugax (HP:0100576)1.90000020
129* Lymphoma (HP:0002665)1.89349426
130Papilledema (HP:0001085)1.87875818
131Mucopolysacchariduria (HP:0008155)1.87851775
132Urinary glycosaminoglycan excretion (HP:0003541)1.87851775
133Abnormality of the pericardium (HP:0001697)1.87401015
134IgG deficiency (HP:0004315)1.86422089
135Polyneuropathy (HP:0001271)1.85108573

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.79717651
2GRK75.38903528
3JAK14.61983985
4MAP4K13.45459899
5ADRBK23.31803183
6RIPK43.31396617
7ITK3.28514986
8STK102.46724718
9JAK32.28421158
10MAP3K102.24590656
11EPHB12.09419100
12PRPF4B1.89289773
13MST41.85627862
14TYK21.83673676
15FES1.83220728
16CSK1.80919103
17ZAP701.76892902
18MAP2K31.72512876
19LCK1.66381384
20RIPK11.63633369
21GRK61.59839206
22TGFBR21.56318206
23TTN1.56177688
24TRIB31.53202351
25FGFR41.51097711
26MAP3K111.49419971
27PRKCH1.40354606
28EPHA31.24469332
29LRRK21.20256521
30KDR1.19848717
31FGFR31.17115709
32PIM11.16045682
33TAOK31.13888435
34PRKCQ1.13525905
35BTK1.09304892
36MAP3K31.08491706
37SIK20.98590185
38TNK20.97685787
39CDK40.97347005
40SYK0.96309675
41BMPR20.95392420
42HCK0.94471374
43KIT0.93312102
44BLK0.92955710
45MAP3K140.90114381
46IKBKE0.88754510
47NLK0.86796328
48CAMKK20.86033978
49TBK10.83533844
50SIK30.80243820
51MARK30.79293157
52CLK10.78895828
53CDK120.78539885
54DMPK0.77918509
55ALK0.76512289
56IRAK30.75507436
57IGF1R0.75384061
58TEC0.74700462
59JAK20.70860540
60TLK10.70035970
61MAP3K10.67715700
62STK240.65792300
63PKN20.64670759
64LYN0.61596735
65INSR0.61100583
66TYRO30.59772253
67MATK0.59706704
68CAMKK10.59523757
69MOS0.59311226
70BMX0.58408711
71RPS6KA40.57707591
72GSK3A0.56950140
73EEF2K0.55994872
74PRKD20.53206896
75PDGFRB0.50846185
76ERN10.49376590
77HIPK20.48547109
78MAPK120.45945523
79IRAK40.44541166
80PTK60.44197908
81FYN0.43387453
82KSR20.43205432
83PTK20.42904945
84GRK50.41549304
85TAOK20.41063067
86MAP3K70.40389463
87MAP2K60.40081299
88MAPKAPK20.39328572
89PDK10.38544989
90YES10.37701138
91STK110.36017602
92STK380.35034314
93MARK20.35014606
94TESK20.34827562
95PDPK10.34607454
96MAPK70.34106812
97PRKG20.33469692
98FGR0.33191736
99IRAK10.32640057
100BCKDK0.31604189
101NUAK10.31467038
102MUSK0.31322060
103TRPM70.30924927
104FGFR10.30182868
105PASK0.30020655
106MELK0.28895949
107MAP3K20.28450862
108MAPK110.27597024
109PRKCD0.27440042
110CSF1R0.27231545
111PIK3CA0.25737520
112MAP3K50.25547567
113MAP3K80.25157376
114BRD40.25025227
115ABL10.24712764
116MAP3K130.24572823
117SRC0.24056429
118MAP3K60.23496942
119TESK10.22774645
120CDC42BPA0.22712028
121PAK40.22649920
122RET0.22528135
123IKBKB0.22482180
124ROCK20.22200298
125CAMK1G0.22014558
126MAPK40.21808517
127ILK0.21053990
128CDK60.19231890
129SGK30.19207799
130TAOK10.18520964
131RPS6KA10.18425529
132PIK3CG0.16808250
133MYLK0.16637742
134PTK2B0.15826940

Predicted pathways (KEGG)

RankGene SetZ-score
1* Graft-versus-host disease_Homo sapiens_hsa053327.65820216
2* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046505.43169447
3Antigen processing and presentation_Homo sapiens_hsa046123.64692165
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.56044805
5* Allograft rejection_Homo sapiens_hsa053303.49500544
6* Autoimmune thyroid disease_Homo sapiens_hsa053202.50212021
7Primary immunodeficiency_Homo sapiens_hsa053402.35741477
8* Type I diabetes mellitus_Homo sapiens_hsa049402.34350400
9T cell receptor signaling pathway_Homo sapiens_hsa046602.21458581
10Measles_Homo sapiens_hsa051622.10274750
11Malaria_Homo sapiens_hsa051441.89625044
12* Viral myocarditis_Homo sapiens_hsa054161.83885672
13Staphylococcus aureus infection_Homo sapiens_hsa051501.80413509
14Leishmaniasis_Homo sapiens_hsa051401.73055645
15Jak-STAT signaling pathway_Homo sapiens_hsa046301.62250156
16Osteoclast differentiation_Homo sapiens_hsa043801.61224732
17Leukocyte transendothelial migration_Homo sapiens_hsa046701.60092751
18Toxoplasmosis_Homo sapiens_hsa051451.52309996
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.32778844
20B cell receptor signaling pathway_Homo sapiens_hsa046621.30638709
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21256286
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.19148553
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.18873477
24Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18676765
25Chemokine signaling pathway_Homo sapiens_hsa040621.15537367
26* Apoptosis_Homo sapiens_hsa042101.15479314
27Pertussis_Homo sapiens_hsa051331.15316347
28Shigellosis_Homo sapiens_hsa051311.12321326
29Asthma_Homo sapiens_hsa053101.08539737
30Hematopoietic cell lineage_Homo sapiens_hsa046401.05483873
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05039375
32Platelet activation_Homo sapiens_hsa046111.03612846
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.02461855
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97400192
35African trypanosomiasis_Homo sapiens_hsa051430.97119130
36Pancreatic cancer_Homo sapiens_hsa052120.96847205
37Tuberculosis_Homo sapiens_hsa051520.90949968
38HTLV-I infection_Homo sapiens_hsa051660.88304379
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87765704
40Acute myeloid leukemia_Homo sapiens_hsa052210.85909065
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84915567
42Hepatitis B_Homo sapiens_hsa051610.84597451
43Endocytosis_Homo sapiens_hsa041440.83768736
44VEGF signaling pathway_Homo sapiens_hsa043700.83636505
45Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82992611
46Colorectal cancer_Homo sapiens_hsa052100.82838877
47TNF signaling pathway_Homo sapiens_hsa046680.82653821
48Chronic myeloid leukemia_Homo sapiens_hsa052200.82315306
49Salmonella infection_Homo sapiens_hsa051320.81121170
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78013918
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76280018
52Caffeine metabolism_Homo sapiens_hsa002320.74629607
53Renal cell carcinoma_Homo sapiens_hsa052110.74603884
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74521625
55Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73233843
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.69010203
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67423377
58Influenza A_Homo sapiens_hsa051640.64079382
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62686633
60Focal adhesion_Homo sapiens_hsa045100.61166174
61Herpes simplex infection_Homo sapiens_hsa051680.59733175
62Rheumatoid arthritis_Homo sapiens_hsa053230.59389985
63Amoebiasis_Homo sapiens_hsa051460.57731621
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56991084
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53598923
66Rap1 signaling pathway_Homo sapiens_hsa040150.52234772
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.51176905
68Small cell lung cancer_Homo sapiens_hsa052220.50939242
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49883409
70Legionellosis_Homo sapiens_hsa051340.48844877
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48034770
72Epstein-Barr virus infection_Homo sapiens_hsa051690.47787505
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46854018
74Hepatitis C_Homo sapiens_hsa051600.44217560
75Regulation of autophagy_Homo sapiens_hsa041400.43594906
76Proteoglycans in cancer_Homo sapiens_hsa052050.42871744
77Non-small cell lung cancer_Homo sapiens_hsa052230.42090366
78Choline metabolism in cancer_Homo sapiens_hsa052310.41876269
79Viral carcinogenesis_Homo sapiens_hsa052030.41558895
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.41325676
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40854268
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40074529
83Prolactin signaling pathway_Homo sapiens_hsa049170.38150143
84Dilated cardiomyopathy_Homo sapiens_hsa054140.38078741
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37568122
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.35818566
87FoxO signaling pathway_Homo sapiens_hsa040680.33752107
88Inositol phosphate metabolism_Homo sapiens_hsa005620.32496896
89Complement and coagulation cascades_Homo sapiens_hsa046100.31077092
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30738102
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.29680340
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28910704
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.28793811
94MAPK signaling pathway_Homo sapiens_hsa040100.27261599
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.26275691
96Adherens junction_Homo sapiens_hsa045200.25598484
97Dorso-ventral axis formation_Homo sapiens_hsa043200.25190872
98Linoleic acid metabolism_Homo sapiens_hsa005910.25175519
99Prion diseases_Homo sapiens_hsa050200.24553268
100Insulin resistance_Homo sapiens_hsa049310.24501707
101mTOR signaling pathway_Homo sapiens_hsa041500.24170150
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22699543
103PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21511739
104Lysosome_Homo sapiens_hsa041420.20824817
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.20040093
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19869516
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.19573409
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.18581033
109Long-term potentiation_Homo sapiens_hsa047200.17955910
110Type II diabetes mellitus_Homo sapiens_hsa049300.17646545
111Ras signaling pathway_Homo sapiens_hsa040140.17251229
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17149267
113Notch signaling pathway_Homo sapiens_hsa043300.15226030
114Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.14836143
115Endometrial cancer_Homo sapiens_hsa052130.14449185
116GnRH signaling pathway_Homo sapiens_hsa049120.14071308
117MicroRNAs in cancer_Homo sapiens_hsa052060.14009927
118ABC transporters_Homo sapiens_hsa020100.13958360
119Sphingolipid metabolism_Homo sapiens_hsa006000.13560831
120Phagosome_Homo sapiens_hsa041450.13208602
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.12677603
122ECM-receptor interaction_Homo sapiens_hsa045120.11909147
123cAMP signaling pathway_Homo sapiens_hsa040240.11867116

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