PRG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of response to osmotic stress (GO:0047484)8.78427610
2mannose metabolic process (GO:0006013)7.38697109
3defense response to fungus (GO:0050832)7.29892894
4leukocyte aggregation (GO:0070486)7.29187447
5eosinophil migration (GO:0072677)7.07824776
6positive regulation of interleukin-8 biosynthetic process (GO:0045416)7.06058917
7leukocyte migration involved in inflammatory response (GO:0002523)7.05195403
8respiratory burst (GO:0045730)6.85304984
9superoxide anion generation (GO:0042554)6.66753941
10disruption of cells of other organism involved in symbiotic interaction (GO:0051818)6.61589263
11killing of cells in other organism involved in symbiotic interaction (GO:0051883)6.61589263
12response to fungus (GO:0009620)6.59173882
13neutrophil activation (GO:0042119)6.55930612
14sequestering of metal ion (GO:0051238)6.53367231
15* negative regulation of interleukin-10 production (GO:0032693)6.43535107
16innate immune response in mucosa (GO:0002227)6.36747949
17nuclear pore complex assembly (GO:0051292)6.11871972
18granulocyte activation (GO:0036230)5.98394567
19DNA unwinding involved in DNA replication (GO:0006268)5.75552228
20neutrophil mediated immunity (GO:0002446)5.68699056
21reactive oxygen species biosynthetic process (GO:1903409)5.42774816
22G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.39971211
23nuclear pore organization (GO:0006999)5.32597414
24negative regulation of phagocytosis (GO:0050765)5.29101284
25antimicrobial humoral response (GO:0019730)5.20111723
26regulation of T cell tolerance induction (GO:0002664)5.19413349
27mucosal immune response (GO:0002385)5.17431719
28regulation of tolerance induction (GO:0002643)5.03890042
29imidazole-containing compound metabolic process (GO:0052803)4.98207298
30chronic inflammatory response (GO:0002544)4.93023813
31killing of cells of other organism (GO:0031640)4.91102177
32disruption of cells of other organism (GO:0044364)4.91102177
33organ or tissue specific immune response (GO:0002251)4.83035305
34cellular extravasation (GO:0045123)4.81289132
35hydrogen peroxide biosynthetic process (GO:0050665)4.77805792
36response to peptidoglycan (GO:0032494)4.77211239
37pore complex assembly (GO:0046931)4.62277492
38leukotriene metabolic process (GO:0006691)4.61935401
39neutrophil activation involved in immune response (GO:0002283)4.58761199
40protein maturation by protein folding (GO:0022417)4.57891514
41DNA replication initiation (GO:0006270)4.51070945
42regulation of interleukin-8 biosynthetic process (GO:0045414)4.50771416
43leukotriene biosynthetic process (GO:0019370)4.48974253
44hydrogen peroxide catabolic process (GO:0042744)4.37444457
45negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.37375174
46negative regulation of cell killing (GO:0031342)4.37375174
47dendritic cell chemotaxis (GO:0002407)4.37250753
48cellular response to cholesterol (GO:0071397)4.32205012
49* positive regulation of interleukin-4 production (GO:0032753)4.29472996
50myeloid leukocyte mediated immunity (GO:0002444)4.26851886
51granulocyte migration (GO:0097530)4.25228743
52glucocorticoid receptor signaling pathway (GO:0042921)4.21119682
53regulation of interleukin-5 production (GO:0032674)4.20212743
54DNA strand elongation involved in DNA replication (GO:0006271)4.18723846
55leukocyte mediated cytotoxicity (GO:0001909)4.10118254
56T cell apoptotic process (GO:0070231)4.08265456
57DNA strand elongation (GO:0022616)4.02349345
58dendritic cell migration (GO:0036336)3.88789602
59DNA topological change (GO:0006265)3.85344318
60positive regulation of growth hormone secretion (GO:0060124)3.82339898
61activated T cell proliferation (GO:0050798)3.79938731
62determination of adult lifespan (GO:0008340)3.76480759
63neutrophil chemotaxis (GO:0030593)3.75956353
64pentose-phosphate shunt (GO:0006098)3.74850222
65protein N-linked glycosylation via asparagine (GO:0018279)3.73460416
66peptidyl-asparagine modification (GO:0018196)3.71449286
67hydrogen peroxide metabolic process (GO:0042743)3.70789966
68macrophage differentiation (GO:0030225)3.69253208
69DNA duplex unwinding (GO:0032508)3.68984724
70Arp2/3 complex-mediated actin nucleation (GO:0034314)3.67065233
71citrulline biosynthetic process (GO:0019240)3.66021857
72neutrophil migration (GO:1990266)3.65293634
73peptidyl-proline hydroxylation (GO:0019511)3.62617058
74regulation of T cell cytokine production (GO:0002724)3.60621557
75negative regulation of monooxygenase activity (GO:0032769)3.60500741
76G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.60210905
77antigen processing and presentation of endogenous antigen (GO:0019883)3.59761221
78iron ion import (GO:0097286)3.59694053
79DNA geometric change (GO:0032392)3.58969000
80positive regulation of B cell differentiation (GO:0045579)3.58160302
81regulation of myeloid leukocyte mediated immunity (GO:0002886)3.56614474
82production of molecular mediator involved in inflammatory response (GO:0002532)3.55463698
83antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.54226372
84T cell migration (GO:0072678)3.52477873
85DNA synthesis involved in DNA repair (GO:0000731)3.49229777
86antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.49229460
87antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.49229460
88maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.49009937
89positive regulation of megakaryocyte differentiation (GO:0045654)3.46287086
90protein N-linked glycosylation (GO:0006487)3.45046622
91regulation of leukocyte degranulation (GO:0043300)3.44859874
92cell killing (GO:0001906)3.44182248
93positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.40716685
94myeloid leukocyte migration (GO:0097529)3.39650715
95modulation of growth of symbiont involved in interaction with host (GO:0044144)3.38611527
96regulation of growth of symbiont in host (GO:0044126)3.38611527
97negative regulation of growth of symbiont in host (GO:0044130)3.38611527
98negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.38611527
99corticosteroid receptor signaling pathway (GO:0031958)3.35399848
100NADPH regeneration (GO:0006740)3.33882372
101regulation of mast cell activation involved in immune response (GO:0033006)3.33080116
102regulation of mast cell activation (GO:0033003)3.32519305
103positive regulation of Cdc42 GTPase activity (GO:0043089)3.31333665
104lymphocyte apoptotic process (GO:0070227)3.31256585
105protoporphyrinogen IX metabolic process (GO:0046501)3.29799117
106oxygen transport (GO:0015671)3.29312462
107telomere maintenance via semi-conservative replication (GO:0032201)3.29266860
108negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.28289194
109purinergic nucleotide receptor signaling pathway (GO:0035590)3.24750740
110positive regulation of gamma-delta T cell activation (GO:0046645)3.23170501
1114-hydroxyproline metabolic process (GO:0019471)3.22037861
112regulation of hypersensitivity (GO:0002883)3.19020904
113granulocyte chemotaxis (GO:0071621)3.18161880
114leukocyte tethering or rolling (GO:0050901)3.16709388
115cellular response to sterol (GO:0036315)3.15521502
116protoporphyrinogen IX biosynthetic process (GO:0006782)3.14166612
117leukocyte cell-cell adhesion (GO:0007159)3.14117451
118regulation of regulated secretory pathway (GO:1903305)3.13912886
119modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.11847887
120positive regulation by organism of defense response of other organism involved in symbiotic interact3.11847887
121modulation by symbiont of host immune response (GO:0052553)3.11847887
122positive regulation by symbiont of host defense response (GO:0052509)3.11847887
123modulation by symbiont of host defense response (GO:0052031)3.11847887
124modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.11847887
125negative regulation of interleukin-12 production (GO:0032695)3.10723165
126response to host immune response (GO:0052572)3.07875792
127response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.07875792
128replication fork processing (GO:0031297)3.06940697
129regulation of translational fidelity (GO:0006450)3.06807003
130proline biosynthetic process (GO:0006561)3.02103344
131positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.01680123
132T cell proliferation (GO:0042098)3.01062811
133regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.00302340
134superoxide metabolic process (GO:0006801)3.00236144
135defense response to Gram-positive bacterium (GO:0050830)2.96363419
136regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.94799850
137positive regulation of granulocyte differentiation (GO:0030854)2.93639720
138regulation of B cell differentiation (GO:0045577)2.90335511
139regulation of B cell receptor signaling pathway (GO:0050855)2.90094774
140dosage compensation (GO:0007549)2.89985451
141regulation of double-strand break repair via homologous recombination (GO:0010569)2.87849020
142* regulation of interleukin-4 production (GO:0032673)2.86647017
143regulation of dendritic cell antigen processing and presentation (GO:0002604)2.84465402
144regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.83992262
145positive regulation of granulocyte chemotaxis (GO:0071624)2.83362030
146cellular biogenic amine biosynthetic process (GO:0042401)2.82049567
147regulation of histone H3-K9 methylation (GO:0051570)2.81822504
148telomere maintenance via recombination (GO:0000722)2.81442785
149response to cholesterol (GO:0070723)2.80822093
150positive regulation of mast cell activation (GO:0033005)2.80606092
151mast cell activation involved in immune response (GO:0002279)2.77130193
152mast cell degranulation (GO:0043303)2.77130193
153response to host (GO:0075136)2.77028636
154response to host defenses (GO:0052200)2.77028636
155response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.77028636
156NIK/NF-kappaB signaling (GO:0038061)2.74808174
157regulation of mast cell degranulation (GO:0043304)2.70940162
158regulation of growth hormone secretion (GO:0060123)2.69783637
159germinal center formation (GO:0002467)2.69633504
160positive regulation of mast cell degranulation (GO:0043306)2.68380101
161positive regulation of mast cell activation involved in immune response (GO:0033008)2.68380101
162detection of other organism (GO:0098543)2.64619518
163immunoglobulin mediated immune response (GO:0016064)2.61235980
164antibacterial humoral response (GO:0019731)2.60838081

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.13657202
2EGR1_19374776_ChIP-ChIP_THP-1_Human5.02433839
3MYB_21317192_ChIP-Seq_ERMYB_Mouse4.63408500
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse4.13925562
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.86723235
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.42298724
7VDR_21846776_ChIP-Seq_THP-1_Human3.31356020
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.24081531
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.11205868
10SCL_19346495_ChIP-Seq_HPC-7_Human3.05922315
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.04735782
12BRD4_27068464_Chip-Seq_AML-cells_Mouse3.01835891
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.96692434
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.86946480
15MYC_22102868_ChIP-Seq_BL_Human2.71791735
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.67068083
17VDR_24763502_ChIP-Seq_THP-1_Human2.62962757
18SPI1_23547873_ChIP-Seq_NB4_Human2.59996368
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.48705975
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.43766360
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.35022714
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.34444115
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.30795748
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.26989290
25MAF_26560356_Chip-Seq_TH1_Human2.15594511
26UTX_26944678_Chip-Seq_JUKART_Human2.12966743
27RUNX1_22412390_ChIP-Seq_EML_Mouse2.10565097
28MYB_26560356_Chip-Seq_TH2_Human2.09783832
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.08638958
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.08596291
31* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.06687396
32STAT4_19710469_ChIP-ChIP_TH1__Mouse2.02774914
33MYB_26560356_Chip-Seq_TH1_Human2.00587857
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.99917972
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.94556513
36TCF7_22412390_ChIP-Seq_EML_Mouse1.92924441
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.90471178
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.89652221
39SPI1_23127762_ChIP-Seq_K562_Human1.87837398
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.87470405
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.77040209
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.76891785
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.73721433
44RUNX_20019798_ChIP-Seq_JUKART_Human1.70026511
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.67609598
46Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.67322773
47PU_27001747_Chip-Seq_BMDM_Mouse1.66327636
48GATA2_22383799_ChIP-Seq_G1ME_Mouse1.65380466
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.62985478
50ESR1_15608294_ChIP-ChIP_MCF-7_Human1.60331212
51GATA1_22383799_ChIP-Seq_G1ME_Mouse1.58465186
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.55135757
53MYC_19030024_ChIP-ChIP_MESCs_Mouse1.53907509
54MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51561429
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50089957
56TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.49433333
57GATA1_22025678_ChIP-Seq_K562_Human1.48701825
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.44779165
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43132546
60PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.38739024
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.38014133
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35695080
63JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.34551259
64FOXP3_21729870_ChIP-Seq_TREG_Human1.31878580
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29182447
66MYC_19079543_ChIP-ChIP_MESCs_Mouse1.28747134
67ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27213407
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25776787
69KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24164312
70ETS1_20019798_ChIP-Seq_JURKAT_Human1.23578955
71VDR_24787735_ChIP-Seq_THP-1_Human1.23536310
72KDM5A_27292631_Chip-Seq_BREAST_Human1.23035104
73* GATA3_27048872_Chip-Seq_THYMUS_Human1.22854147
74IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.21646651
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.20360744
76GATA3_26560356_Chip-Seq_TH2_Human1.20064702
77E2F1_21310950_ChIP-Seq_MCF-7_Human1.19603874
78CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18448509
79TFEB_21752829_ChIP-Seq_HELA_Human1.18399459
80KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.18188707
81KDM2B_26808549_Chip-Seq_DND41_Human1.17868959
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17227446
83NELFA_20434984_ChIP-Seq_ESCs_Mouse1.17012714
84MAF_26560356_Chip-Seq_TH2_Human1.15591693
85FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.15433644
86NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.14149476
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13772758
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13385452
89SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.12964367
90RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.12577328
91KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09961258
92VDR_23849224_ChIP-Seq_CD4+_Human1.09672280
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09094076
94CREB1_15753290_ChIP-ChIP_HEK293T_Human1.08817529
95HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08675239
96STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08672274
97CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06934574
98ELF1_20517297_ChIP-Seq_JURKAT_Human1.06843095
99CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04650364
100RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03739050
101DCP1A_22483619_ChIP-Seq_HELA_Human1.03260788
102THAP11_20581084_ChIP-Seq_MESCs_Mouse0.98233890
103GABP_19822575_ChIP-Seq_HepG2_Human0.98175001
104GATA1_19941826_ChIP-Seq_K562_Human0.98054027
105SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97720987
106* GATA2_19941826_ChIP-Seq_K562_Human0.97703257
107PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96585444
108CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95747539
109CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95271594
110CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95052286
111AR_21909140_ChIP-Seq_LNCAP_Human0.94962493
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93777641
113NCOR1_26117541_ChIP-Seq_K562_Human0.93242854
114SPI1_20517297_ChIP-Seq_HL60_Human0.92960129
115FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92952421
116GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92705759
117PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92363978
118ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92122330
119CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92025391
120ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.92012487
121PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90698394
122LXR_22292898_ChIP-Seq_THP-1_Human0.90185074
123CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90125380
124SRF_21415370_ChIP-Seq_HL-1_Mouse0.89993290
125BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89988221
126XRN2_22483619_ChIP-Seq_HELA_Human0.89318468
127ETS1_22383799_ChIP-Seq_G1ME_Mouse0.86781408
128EST1_17652178_ChIP-ChIP_JURKAT_Human0.85492714
129MYCN_18555785_ChIP-Seq_MESCs_Mouse0.84683700
130CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84021963
131SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.83461486
132CIITA_25753668_ChIP-Seq_RAJI_Human0.82717041
133ELF1_17652178_ChIP-ChIP_JURKAT_Human0.78249590
134TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76861825
135PPARA_22158963_ChIP-Seq_LIVER_Mouse0.76714659

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation5.09980939
2MP0003183_abnormal_peptide_metabolism4.03187667
3MP0003436_decreased_susceptibility_to3.83842597
4MP0001835_abnormal_antigen_presentation3.49142394
5MP0003111_abnormal_nucleus_morphology3.12345371
6MP0002419_abnormal_innate_immunity3.00216238
7MP0009278_abnormal_bone_marrow2.97059131
8MP0009785_altered_susceptibility_to2.92971671
9MP0005025_abnormal_response_to2.68691556
10MP0003300_gastrointestinal_ulcer2.61813014
11MP0000685_abnormal_immune_system2.59291440
12MP0005464_abnormal_platelet_physiology2.49952508
13MP0004147_increased_porphyrin_level2.42357353
14MP0002396_abnormal_hematopoietic_system2.40091379
15MP0002009_preneoplasia2.39275794
16MP0005000_abnormal_immune_tolerance2.32927148
17MP0001800_abnormal_humoral_immune2.27921374
18MP0001545_abnormal_hematopoietic_system2.19678562
19MP0005397_hematopoietic_system_phenotyp2.19678562
20MP0002452_abnormal_antigen_presenting2.16359346
21MP0002420_abnormal_adaptive_immunity2.13582967
22MP0001819_abnormal_immune_cell2.12784400
23MP0010352_gastrointestinal_tract_polyps2.10907677
24MP0003724_increased_susceptibility_to2.07050247
25MP0002148_abnormal_hypersensitivity_rea2.03024932
26MP0002254_reproductive_system_inflammat2.00864560
27MP0000343_altered_response_to2.00287586
28MP0002723_abnormal_immune_serum1.97398943
29* MP0002398_abnormal_bone_marrow1.95197456
30MP0005387_immune_system_phenotype1.93785810
31MP0001790_abnormal_immune_system1.93785810
32MP0001533_abnormal_skeleton_physiology1.92799686
33MP0003786_premature_aging1.91937311
34MP0004808_abnormal_hematopoietic_stem1.89337050
35MP0003656_abnormal_erythrocyte_physiolo1.89016890
36MP0009697_abnormal_copulation1.87641896
37* MP0000716_abnormal_immune_system1.85821030
38MP0000465_gastrointestinal_hemorrhage1.82605452
39* MP0002405_respiratory_system_inflammati1.81680673
40MP0001851_eye_inflammation1.79421578
41* MP0001845_abnormal_inflammatory_respons1.79116215
42MP0005671_abnormal_response_to1.78041567
43MP0008260_abnormal_autophagy1.77092756
44MP0001853_heart_inflammation1.76039714
45MP0002877_abnormal_melanocyte_morpholog1.75728225
46MP0004185_abnormal_adipocyte_glucose1.72321606
47MP0003077_abnormal_cell_cycle1.69178589
48* MP0002429_abnormal_blood_cell1.60632550
49MP0003172_abnormal_lysosome_physiology1.58153185
50MP0010155_abnormal_intestine_physiology1.58052207
51MP0008058_abnormal_DNA_repair1.57357809
52MP0002722_abnormal_immune_system1.52164837
53MP0000858_altered_metastatic_potential1.48507631
54MP0006082_CNS_inflammation1.48320240
55MP0001873_stomach_inflammation1.47804576
56MP0002166_altered_tumor_susceptibility1.47702347
57MP0005075_abnormal_melanosome_morpholog1.46898417
58MP0000689_abnormal_spleen_morphology1.45081903
59MP0004510_myositis1.42152626
60MP0005310_abnormal_salivary_gland1.37550700
61MP0003828_pulmonary_edema1.37524769
62MP0002277_abnormal_respiratory_mucosa1.35850403
63MP0001764_abnormal_homeostasis1.34078659
64MP0008995_early_reproductive_senescence1.30332417
65MP0003566_abnormal_cell_adhesion1.30130269
66MP0003075_altered_response_to1.29211953
67MP0005174_abnormal_tail_pigmentation1.28015093
68MP0005220_abnormal_exocrine_pancreas1.26821772
69MP0001661_extended_life_span1.24294309
70MP0008469_abnormal_protein_level1.23606727
71MP0001765_abnormal_ion_homeostasis1.23001203
72MP0003448_altered_tumor_morphology1.21258825
73MP0004947_skin_inflammation1.20126925
74MP0000703_abnormal_thymus_morphology1.18603562
75MP0003693_abnormal_embryo_hatching1.17923322
76MP0010307_abnormal_tumor_latency1.16428514
77MP0001348_abnormal_lacrimal_gland1.16298819
78MP0002970_abnormal_white_adipose1.15515038
79MP0008007_abnormal_cellular_replicative1.14039126
80MP0004957_abnormal_blastocyst_morpholog1.12087885
81MP0002006_tumorigenesis1.10293748
82MP0004883_abnormal_blood_vessel1.09983436
83MP0005621_abnormal_cell_physiology1.07909041
84MP0009764_decreased_sensitivity_to1.07427829
85MP0009333_abnormal_splenocyte_physiolog1.05102871
86MP0003763_abnormal_thymus_physiology1.02459328
87MP0001529_abnormal_vocalization0.99872670
88MP0001663_abnormal_digestive_system0.97994713
89MP0005076_abnormal_cell_differentiation0.97380040
90MP0004264_abnormal_extraembryonic_tissu0.96045805
91MP0000372_irregular_coat_pigmentation0.95157464
92MP0002928_abnormal_bile_duct0.93860473
93MP0005023_abnormal_wound_healing0.92550004
94MP0005164_abnormal_response_to0.92525762
95MP0005384_cellular_phenotype0.91569189
96MP0006054_spinal_hemorrhage0.91268435
97MP0005083_abnormal_biliary_tract0.88580967
98MP0002075_abnormal_coat/hair_pigmentati0.85723331
99MP0009763_increased_sensitivity_to0.84021436
100MP0005647_abnormal_sex_gland0.83860221
101MP0003191_abnormal_cellular_cholesterol0.83814175
102MP0005058_abnormal_lysosome_morphology0.83448509
103MP0002019_abnormal_tumor_incidence0.82617599
104MP0000569_abnormal_digit_pigmentation0.82572724
105MP0000604_amyloidosis0.80460692
106MP0003705_abnormal_hypodermis_morpholog0.80035152
107MP0009115_abnormal_fat_cell0.79816405
108MP0000015_abnormal_ear_pigmentation0.79325166
109MP0001730_embryonic_growth_arrest0.78852540
110MP0000313_abnormal_cell_death0.78688687
111MP0000490_abnormal_crypts_of0.78634378
112MP0009840_abnormal_foam_cell0.78302418
113MP0003221_abnormal_cardiomyocyte_apopto0.77349352
114MP0002080_prenatal_lethality0.75904446
115MP0009672_abnormal_birth_weight0.73674928
116MP0002933_joint_inflammation0.73356550
117MP0005451_abnormal_body_composition0.72446651
118MP0008873_increased_physiological_sensi0.72272964
119MP0000747_muscle_weakness0.71840368
120MP0006036_abnormal_mitochondrial_physio0.71715163
121MP0010094_abnormal_chromosome_stability0.71074046
122MP0004134_abnormal_chest_morphology0.70559453
123MP0003866_abnormal_defecation0.69708398
124MP0000249_abnormal_blood_vessel0.69387814
125MP0008057_abnormal_DNA_replication0.67987652
126MP0005171_absent_coat_pigmentation0.67948596
127MP0002735_abnormal_chemical_nociception0.67744563
128MP0009765_abnormal_xenobiotic_induced0.67000860
129MP0005388_respiratory_system_phenotype0.66425126
130MP0002133_abnormal_respiratory_system0.66425126
131MP0005167_abnormal_blood-brain_barrier0.66338862
132MP0005390_skeleton_phenotype0.59910045
133MP0001986_abnormal_taste_sensitivity0.57811913
134MP0000920_abnormal_myelination0.57811670
135MP0000609_abnormal_liver_physiology0.56784305
136MP0009931_abnormal_skin_appearance0.56638058
137MP0003795_abnormal_bone_structure0.55755490
138MP0003453_abnormal_keratinocyte_physiol0.55272884

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)8.92405985
2Recurrent gram-negative bacterial infections (HP:0005420)7.59160062
3Recurrent abscess formation (HP:0002722)7.43114900
4Recurrent bacterial skin infections (HP:0005406)7.40926282
5Chronic obstructive pulmonary disease (HP:0006510)5.78643993
6Obstructive lung disease (HP:0006536)5.78643993
7Cellulitis (HP:0100658)5.40405865
8Recurrent fungal infections (HP:0002841)5.38829223
9Recurrent skin infections (HP:0001581)5.20945294
10Abnormality of macrophages (HP:0004311)5.12378661
11Megalencephaly (HP:0001355)4.64216820
12Mediastinal lymphadenopathy (HP:0100721)4.63603590
13Gingivitis (HP:0000230)4.42618886
14Upper motor neuron abnormality (HP:0002127)4.40500638
15Recurrent cutaneous fungal infections (HP:0011370)4.34482118
16Chronic mucocutaneous candidiasis (HP:0002728)4.34482118
17Meningitis (HP:0001287)4.34374792
18Relative macrocephaly (HP:0004482)4.28493142
19Microvesicular hepatic steatosis (HP:0001414)4.05888606
20Urticaria (HP:0001025)4.01294517
21Increased neuronal autofluorescent lipopigment (HP:0002074)3.88505429
2211 pairs of ribs (HP:0000878)3.88210615
23Recurrent viral infections (HP:0004429)3.81657026
24Abnormality of the heme biosynthetic pathway (HP:0010472)3.72005812
25Abnormality of the lumbar spine (HP:0100712)3.66894525
26Spontaneous hematomas (HP:0007420)3.63245093
27Thoracic kyphosis (HP:0002942)3.61327523
28Increased cerebral lipofuscin (HP:0011813)3.57171265
29Chromosomal breakage induced by crosslinking agents (HP:0003221)3.53374436
30Abnormality of the thoracic spine (HP:0100711)3.50173745
31Anteriorly placed anus (HP:0001545)3.49268915
32Osteomyelitis (HP:0002754)3.41333976
33Colitis (HP:0002583)3.38664961
34Abnormal delayed hypersensitivity skin test (HP:0002963)3.35769044
35Nonimmune hydrops fetalis (HP:0001790)3.33872813
36Myositis (HP:0100614)3.25323617
37Pancreatic islet-cell hyperplasia (HP:0004510)3.21136612
38Inflammation of the large intestine (HP:0002037)3.20571840
39Recurrent pneumonia (HP:0006532)3.16573925
40Thrombocytosis (HP:0001894)3.14948818
41Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.14156964
42IgM deficiency (HP:0002850)3.13509512
43Long clavicles (HP:0000890)3.11968203
44Interstitial pulmonary disease (HP:0006530)3.11641764
45Gastrointestinal inflammation (HP:0004386)3.07166592
46Hypochromic microcytic anemia (HP:0004840)3.06023854
47Microglossia (HP:0000171)3.00071125
48Flared metaphyses (HP:0003015)2.99960347
49Dysostosis multiplex (HP:0000943)2.99716119
50Abnormality of B cell number (HP:0010975)2.94654434
51B lymphocytopenia (HP:0010976)2.94654434
52Agammaglobulinemia (HP:0004432)2.94260465
53Periodontitis (HP:0000704)2.93044333
54Chromsome breakage (HP:0040012)2.84588835
55Acute lymphatic leukemia (HP:0006721)2.81572907
56Prolonged bleeding time (HP:0003010)2.81425973
57Epistaxis (HP:0000421)2.80877618
58Petechiae (HP:0000967)2.80788832
59Myelodysplasia (HP:0002863)2.80030657
60Papilledema (HP:0001085)2.76903418
61Hematochezia (HP:0002573)2.74442069
62Reticulocytosis (HP:0001923)2.71767283
63Verrucae (HP:0200043)2.70930715
64Papilloma (HP:0012740)2.70930715
65Abnormality of cochlea (HP:0000375)2.70669247
66Sepsis (HP:0100806)2.68103807
67Chest pain (HP:0100749)2.68091406
68Abnormal foot bone ossification (HP:0010675)2.66723611
69Recurrent lower respiratory tract infections (HP:0002783)2.66292995
70Pulmonary infiltrates (HP:0002113)2.66073256
71Type I transferrin isoform profile (HP:0003642)2.65125702
72Paralysis (HP:0003470)2.64213069
73Hepatosplenomegaly (HP:0001433)2.63880231
74Broad ribs (HP:0000885)2.61042745
75Abnormal platelet function (HP:0011869)2.60649586
76Impaired platelet aggregation (HP:0003540)2.60649586
77Amaurosis fugax (HP:0100576)2.59660120
78Vasculitis (HP:0002633)2.57374642
79Elevated erythrocyte sedimentation rate (HP:0003565)2.56137273
80Abnormal platelet volume (HP:0011876)2.56017840
81Hemoptysis (HP:0002105)2.55828116
82Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.55693524
83Abnormal protein N-linked glycosylation (HP:0012347)2.55693524
84Abnormal protein glycosylation (HP:0012346)2.55693524
85Abnormal glycosylation (HP:0012345)2.55693524
86Gingival bleeding (HP:0000225)2.55676988
87Lower limb hyperreflexia (HP:0002395)2.52460805
88Skin ulcer (HP:0200042)2.51415573
89Visual hallucinations (HP:0002367)2.51049954
90Chronic otitis media (HP:0000389)2.49688645
91Abnormality of T cell physiology (HP:0011840)2.48027079
92Stomatitis (HP:0010280)2.44426834
93Metaphyseal cupping (HP:0003021)2.40005144
94Bone marrow hypocellularity (HP:0005528)2.39439109
95Pulmonary embolism (HP:0002204)2.36394096
96Keratoconjunctivitis (HP:0001096)2.36059294
97Acute hepatic failure (HP:0006554)2.34019011
98Congenital malformation of the right heart (HP:0011723)2.32305448
99Double outlet right ventricle (HP:0001719)2.32305448
100Poikilocytosis (HP:0004447)2.31773393
101Pseudobulbar signs (HP:0002200)2.28522800
102Abnormality of reticulocytes (HP:0004312)2.28328792
103Increased IgE level (HP:0003212)2.25127698
104Dysmetric saccades (HP:0000641)2.22485147
105Pallor (HP:0000980)2.21539991
106Abnormality of the lower motor neuron (HP:0002366)2.20679526
107Abnormality of the prostate (HP:0008775)2.17866050
108Hypochromic anemia (HP:0001931)2.17515934
109Orchitis (HP:0100796)2.14562398
110Arterial thrombosis (HP:0004420)2.14503000
111Pustule (HP:0200039)2.13916554
112Increased mean platelet volume (HP:0011877)2.13776472
113Eosinophilia (HP:0001880)2.13016507
114Acrocyanosis (HP:0001063)2.12688007
115Disinhibition (HP:0000734)2.05051110
116Leukocytosis (HP:0001974)2.05051068
117Menorrhagia (HP:0000132)2.03405216
118Pulmonary fibrosis (HP:0002206)2.03380338
119Mucosal telangiectasiae (HP:0100579)2.02991634
120Scanning speech (HP:0002168)2.02225412
121Abnormality of ocular smooth pursuit (HP:0000617)2.02032845
122Premature ovarian failure (HP:0008209)2.00797010
123Thrombophlebitis (HP:0004418)1.97735899
124Peripheral hypomyelination (HP:0007182)1.97597959
125Recurrent bronchitis (HP:0002837)1.97188549
126Skin rash (HP:0000988)1.94394174
127Missing ribs (HP:0000921)1.93215527
128Restrictive lung disease (HP:0002091)1.92725743
129Thickened calvaria (HP:0002684)1.92370371
130Increased density of long bones (HP:0006392)1.92257745
131Abnormality of the pancreatic islet cells (HP:0006476)1.91641111
132Abnormality of endocrine pancreas physiology (HP:0012093)1.91641111
133Cheilitis (HP:0100825)1.90291396
134Hypergonadotropic hypogonadism (HP:0000815)1.89883757
135Neurodegeneration (HP:0002180)1.89028855
136Granulocytopenia (HP:0001913)1.87590067
137Xerostomia (HP:0000217)1.87253135
138Abnormality of the corticospinal tract (HP:0002492)1.86825594
139Morphological abnormality of the inner ear (HP:0011390)1.86823114
140Thyroiditis (HP:0100646)1.86487571
141Abnormality of iron homeostasis (HP:0011031)1.84779709
142Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.84605591
143Panhypogammaglobulinemia (HP:0003139)1.84430663
144Gastrointestinal stroma tumor (HP:0100723)1.84162496
145Cutaneous photosensitivity (HP:0000992)1.82606632
146Abnormality of the common coagulation pathway (HP:0010990)1.81532388
147Abnormal number of erythroid precursors (HP:0012131)1.81420063
148Acute myeloid leukemia (HP:0004808)1.79906589
149Toxemia of pregnancy (HP:0100603)1.78850319
150Increased serum ferritin (HP:0003281)1.78145005
151Abnormality of T cells (HP:0002843)1.77040569
152Birth length less than 3rd percentile (HP:0003561)1.76422343
153Vacuolated lymphocytes (HP:0001922)1.75994387
154Retrobulbar optic neuritis (HP:0100654)1.75483448
155Optic neuritis (HP:0100653)1.75483448
156Sandal gap (HP:0001852)1.75474923
157Clubbing of toes (HP:0100760)1.75181026
158Abnormality of eosinophils (HP:0001879)1.74379206
159Hypermelanotic macule (HP:0001034)1.73670094
160Abnormality of cells of the lymphoid lineage (HP:0012140)1.73039182
161Spondylolisthesis (HP:0003302)1.72984662
162Encephalitis (HP:0002383)1.71763082
163Recurrent sinusitis (HP:0011108)1.68960758
164Osteolytic defects of the phalanges of the hand (HP:0009771)1.68620326
165Osteolytic defects of the hand bones (HP:0009699)1.68620326
166Purpura (HP:0000979)1.68607277
167Lymphopenia (HP:0001888)1.66946731

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK45.81139813
2EPHB13.53872023
3MAP4K13.02340596
4ERN12.89306945
5BTK2.85323977
6EEF2K2.56560781
7RIPK42.48156662
8GRK62.47365795
9TAOK32.46058463
10GRK12.25060072
11PRPF4B2.18992743
12TEC2.16338114
13ZAK2.11345720
14TYK22.05888893
15LRRK22.03518283
16FES1.90482053
17MAP3K141.88185819
18NME21.81521081
19BLK1.78228174
20STK101.75940368
21PLK41.74570130
22ALK1.69901866
23CSK1.62749309
24FLT31.60341165
25SYK1.59804390
26HCK1.56887592
27MAP3K121.51064783
28PTK61.48117261
29CLK11.45115873
30ZAP701.43975170
31ITK1.40126821
32TRIB31.39770407
33TTN1.37337741
34TESK21.37303736
35TLK11.36209471
36KIT1.32863042
37MAP2K31.32602391
38TRPM71.26618724
39ICK1.24360921
40MATK1.22029039
41SMG11.21541227
42PAK41.16464524
43JAK31.15837798
44TBK11.11673829
45PKN21.11626547
46CSF1R1.08239743
47PIM11.07536996
48IRAK31.06634558
49RPS6KC11.06474184
50RPS6KL11.06474184
51PIK3CG1.05624431
52CDK121.03207770
53IKBKE1.02182578
54PRKG20.98709544
55RAF10.95366241
56JAK20.93280738
57FGFR30.92200412
58CHEK20.89879200
59SIK20.87347216
60NEK20.86658002
61EPHA30.86626526
62LYN0.86492870
63MAP3K90.86263747
64RPS6KA50.85834097
65KSR20.85310129
66SCYL20.83999022
67TTK0.83852449
68TRIM280.83504892
69RPS6KB20.83058699
70TNK20.82437963
71IRAK20.82136954
72MAPK110.81319662
73MAP3K100.79486863
74MAP3K60.77140325
75MAPK40.77125334
76PASK0.76365769
77PRKCQ0.76182062
78MAP3K110.75256406
79MAP2K20.75036321
80CDC70.74355057
81ATM0.74340770
82LCK0.72656892
83RPS6KA40.71334972
84CHEK10.67141982
85FRK0.63948040
86FGR0.63038709
87MAPKAPK30.63028897
88RIPK10.61821984
89JAK10.61033255
90CCNB10.59999593
91CDK60.59591221
92CDK20.58710027
93MAP3K130.58693102
94TESK10.58372149
95TAOK10.56915916
96PRKDC0.55945017
97CAMK1D0.55917400
98PTK2B0.54461775
99RPS6KB10.54106768
100IKBKB0.53937872
101PRKCD0.53757974
102CDK40.52873665
103PIM20.51816900
104AURKB0.51507443
105HIPK20.51352064
106MAP3K80.51005104
107MAP2K40.50438866
108MAPKAPK20.49564404
109ERBB30.49286164
110TAOK20.48637117
111CDK10.48422030
112AKT10.48145666
113NLK0.47363144
114SRPK10.46543628
115ACVR1B0.46248223
116AURKA0.46009063
117EGFR0.45724153
118CDK70.45698639
119BRD40.45587144
120MAP3K10.45431261
121MARK30.44234470
122MAPK30.43857221
123RPS6KA20.43651280
124PDPK10.43445676
125CSNK2A20.41970499
126FYN0.41607582
127MAP2K60.41566505
128DAPK10.41180169
129DMPK0.40853449
130STK240.40633267
131STK110.40387301
132PRKAA20.39980060
133PLK10.38395953
134NTRK10.37320131
135TXK0.36464668
136MAPK120.34514391
137STK40.34481949
138BUB10.33931929
139PRKCI0.33029532
140BMX0.32214582
141ATR0.31726618
142PDK10.31048486
143CAMK1G0.30815154
144EIF2AK10.30712497
145FGFR40.30577473
146RPS6KA60.30525690

Predicted pathways (KEGG)

RankGene SetZ-score
1* Asthma_Homo sapiens_hsa053106.10957754
2Leishmaniasis_Homo sapiens_hsa051403.95426811
3Osteoclast differentiation_Homo sapiens_hsa043802.77181741
4Systemic lupus erythematosus_Homo sapiens_hsa053222.72945293
5Staphylococcus aureus infection_Homo sapiens_hsa051502.69320083
6Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.34018674
7Homologous recombination_Homo sapiens_hsa034402.29118072
8B cell receptor signaling pathway_Homo sapiens_hsa046622.23148664
9Leukocyte transendothelial migration_Homo sapiens_hsa046702.22357221
10Mismatch repair_Homo sapiens_hsa034302.19620596
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.14897841
12Glycerophospholipid metabolism_Homo sapiens_hsa005642.09490772
13Fanconi anemia pathway_Homo sapiens_hsa034602.04890568
14Chemokine signaling pathway_Homo sapiens_hsa040621.98724032
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.90687754
16Alcoholism_Homo sapiens_hsa050341.88262478
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.75947190
18Tuberculosis_Homo sapiens_hsa051521.73753480
19Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.72419568
20Hematopoietic cell lineage_Homo sapiens_hsa046401.72323159
21Legionellosis_Homo sapiens_hsa051341.69468173
22Pertussis_Homo sapiens_hsa051331.68679000
23Ether lipid metabolism_Homo sapiens_hsa005651.67249250
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.66295233
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.62799815
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.62106846
27Chronic myeloid leukemia_Homo sapiens_hsa052201.57704323
28Pentose phosphate pathway_Homo sapiens_hsa000301.55834552
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.53638740
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53039599
31Nucleotide excision repair_Homo sapiens_hsa034201.52335034
32Antigen processing and presentation_Homo sapiens_hsa046121.51664174
33Primary immunodeficiency_Homo sapiens_hsa053401.48869887
34Platelet activation_Homo sapiens_hsa046111.48405790
35Acute myeloid leukemia_Homo sapiens_hsa052211.47237105
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.42962989
37Pancreatic cancer_Homo sapiens_hsa052121.42534848
38Toxoplasmosis_Homo sapiens_hsa051451.41775234
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.41545861
40Malaria_Homo sapiens_hsa051441.39476981
41Hepatitis B_Homo sapiens_hsa051611.39102294
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.29687734
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.29552038
44Shigellosis_Homo sapiens_hsa051311.27119068
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.22522831
46Measles_Homo sapiens_hsa051621.22490460
47Phagosome_Homo sapiens_hsa041451.22029196
48Neurotrophin signaling pathway_Homo sapiens_hsa047221.19909912
49Renin-angiotensin system_Homo sapiens_hsa046141.14940404
50DNA replication_Homo sapiens_hsa030301.14272568
51VEGF signaling pathway_Homo sapiens_hsa043701.12160902
52Jak-STAT signaling pathway_Homo sapiens_hsa046301.07437057
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03524659
54Non-small cell lung cancer_Homo sapiens_hsa052231.01200590
55Amoebiasis_Homo sapiens_hsa051461.00287332
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99953934
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98744092
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.98512002
59RNA transport_Homo sapiens_hsa030130.97700621
60Influenza A_Homo sapiens_hsa051640.95263222
61Apoptosis_Homo sapiens_hsa042100.94314121
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93035502
63Arginine biosynthesis_Homo sapiens_hsa002200.90618486
64Dorso-ventral axis formation_Homo sapiens_hsa043200.89455284
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89255851
66Fatty acid biosynthesis_Homo sapiens_hsa000610.89014671
67N-Glycan biosynthesis_Homo sapiens_hsa005100.86842907
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85824798
69Vitamin digestion and absorption_Homo sapiens_hsa049770.85554503
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85455002
71ABC transporters_Homo sapiens_hsa020100.85357168
72Herpes simplex infection_Homo sapiens_hsa051680.84975458
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84826069
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84022979
75Salmonella infection_Homo sapiens_hsa051320.83600234
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83249923
77Other glycan degradation_Homo sapiens_hsa005110.81642726
78Fatty acid metabolism_Homo sapiens_hsa012120.80695083
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.79482348
80Pyrimidine metabolism_Homo sapiens_hsa002400.76640071
81African trypanosomiasis_Homo sapiens_hsa051430.76320853
82TNF signaling pathway_Homo sapiens_hsa046680.76042608
83T cell receptor signaling pathway_Homo sapiens_hsa046600.75672795
84Protein export_Homo sapiens_hsa030600.74467352
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72144599
86Spliceosome_Homo sapiens_hsa030400.69885547
87Cell cycle_Homo sapiens_hsa041100.69591432
88Thyroid hormone synthesis_Homo sapiens_hsa049180.68123042
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.66172308
90Hepatitis C_Homo sapiens_hsa051600.65436459
91Viral carcinogenesis_Homo sapiens_hsa052030.64232342
92Insulin resistance_Homo sapiens_hsa049310.63711232
93Small cell lung cancer_Homo sapiens_hsa052220.59982825
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59069100
95Biosynthesis of amino acids_Homo sapiens_hsa012300.58872326
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58356260
97Glioma_Homo sapiens_hsa052140.58037631
98Starch and sucrose metabolism_Homo sapiens_hsa005000.57581633
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.56642493
100HTLV-I infection_Homo sapiens_hsa051660.54897911
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54480475
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53829829
103Colorectal cancer_Homo sapiens_hsa052100.53703436
104Ribosome_Homo sapiens_hsa030100.53639398
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52741775
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52359778
107Fructose and mannose metabolism_Homo sapiens_hsa000510.51470445
108mRNA surveillance pathway_Homo sapiens_hsa030150.50629632
109Viral myocarditis_Homo sapiens_hsa054160.50312407
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50290951
111Epstein-Barr virus infection_Homo sapiens_hsa051690.49986238
112Renal cell carcinoma_Homo sapiens_hsa052110.49618063
113Prolactin signaling pathway_Homo sapiens_hsa049170.48405917
114Lysosome_Homo sapiens_hsa041420.47066665
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46683899
116Estrogen signaling pathway_Homo sapiens_hsa049150.45535039
117MicroRNAs in cancer_Homo sapiens_hsa052060.44849543
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43400041
119Inositol phosphate metabolism_Homo sapiens_hsa005620.42470893
120Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42073114
121Rap1 signaling pathway_Homo sapiens_hsa040150.41946068
122mTOR signaling pathway_Homo sapiens_hsa041500.41925515
123RNA polymerase_Homo sapiens_hsa030200.41889990
124Nitrogen metabolism_Homo sapiens_hsa009100.41477075
125Proteoglycans in cancer_Homo sapiens_hsa052050.40972192
126Complement and coagulation cascades_Homo sapiens_hsa046100.39546607
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.38935868
128MAPK signaling pathway_Homo sapiens_hsa040100.38842728
129Base excision repair_Homo sapiens_hsa034100.37847768
130Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36142399
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34844239
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.33920433
133FoxO signaling pathway_Homo sapiens_hsa040680.33796909
134Non-homologous end-joining_Homo sapiens_hsa034500.33567232
135Galactose metabolism_Homo sapiens_hsa000520.33286807
136HIF-1 signaling pathway_Homo sapiens_hsa040660.33052041
137Endocytosis_Homo sapiens_hsa041440.32493876
138Histidine metabolism_Homo sapiens_hsa003400.30400877
139Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29732853
140Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29035670
141Phospholipase D signaling pathway_Homo sapiens_hsa040720.27254961
142Steroid biosynthesis_Homo sapiens_hsa001000.26455443
143One carbon pool by folate_Homo sapiens_hsa006700.26422503
144Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25344949
145Sphingolipid metabolism_Homo sapiens_hsa006000.24603125
146Purine metabolism_Homo sapiens_hsa002300.24574543
147Metabolic pathways_Homo sapiens_hsa011000.24162472
148Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.22568053
149Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.18291372

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