PRG4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a large proteoglycan that is synthesized by chondrocytes located at the surface of articular cartilage and by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1opsonization (GO:0008228)9.51317934
2complement activation, alternative pathway (GO:0006957)8.46941102
3regulation of integrin activation (GO:0033623)8.01931189
4drug catabolic process (GO:0042737)7.86245486
5exogenous drug catabolic process (GO:0042738)7.80209454
6apoptotic cell clearance (GO:0043277)7.43430756
7glyoxylate metabolic process (GO:0046487)7.29887341
8L-phenylalanine catabolic process (GO:0006559)7.21183353
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.21183353
10mannose metabolic process (GO:0006013)7.17326166
11regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)6.62494358
12L-phenylalanine metabolic process (GO:0006558)6.51840048
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.51840048
14regulation of complement activation (GO:0030449)6.36266139
15blood coagulation, intrinsic pathway (GO:0007597)6.16674278
16regulation of protein activation cascade (GO:2000257)6.07518314
17lipoxygenase pathway (GO:0019372)6.05428304
18urea metabolic process (GO:0019627)5.98726703
19cellular glucuronidation (GO:0052695)5.96288514
20ethanol oxidation (GO:0006069)5.85596267
21uronic acid metabolic process (GO:0006063)5.81524337
22glucuronate metabolic process (GO:0019585)5.81524337
23drug metabolic process (GO:0017144)5.76344883
24bile acid biosynthetic process (GO:0006699)5.75122230
25complement activation (GO:0006956)5.60714293
26oxidative demethylation (GO:0070989)5.59336714
27phenylpropanoid metabolic process (GO:0009698)5.44520027
28serine family amino acid catabolic process (GO:0009071)5.39928382
29nitrogen cycle metabolic process (GO:0071941)5.35541904
30regulation of triglyceride catabolic process (GO:0010896)5.28356957
31aromatic amino acid family catabolic process (GO:0009074)5.27274175
32epoxygenase P450 pathway (GO:0019373)5.12079048
33urea cycle (GO:0000050)5.09334892
34bile acid metabolic process (GO:0008206)5.04614010
35regulation of plasminogen activation (GO:0010755)5.02900464
36endothelial cell chemotaxis (GO:0035767)5.02009275
37acylglycerol homeostasis (GO:0055090)5.01074353
38triglyceride homeostasis (GO:0070328)5.01074353
39citrulline biosynthetic process (GO:0019240)4.90745871
40regulation of humoral immune response (GO:0002920)4.89046464
41glycine metabolic process (GO:0006544)4.87236648
42peptidyl-glutamic acid carboxylation (GO:0017187)4.75155909
43protein carboxylation (GO:0018214)4.75155909
44leukocyte migration involved in inflammatory response (GO:0002523)4.74970482
45detection of molecule of bacterial origin (GO:0032490)4.73036069
46ethanol metabolic process (GO:0006067)4.72931109
47long-chain fatty acid biosynthetic process (GO:0042759)4.71574719
48negative regulation of sterol transport (GO:0032372)4.70606010
49negative regulation of cholesterol transport (GO:0032375)4.70606010
50germinal center formation (GO:0002467)4.70242838
51negative regulation of hemostasis (GO:1900047)4.68937093
52negative regulation of blood coagulation (GO:0030195)4.68937093
53bile acid and bile salt transport (GO:0015721)4.64054984
54complement activation, classical pathway (GO:0006958)4.61088793
55alkaloid metabolic process (GO:0009820)4.39074789
56regulation of endothelial cell chemotaxis (GO:2001026)4.38155632
57negative regulation of wound healing (GO:0061045)4.33630809
58sequestering of extracellular ligand from receptor (GO:0035581)4.30869798
59negative regulation of coagulation (GO:0050819)4.30760682
60protein activation cascade (GO:0072376)4.29938918
61regulation of macrophage chemotaxis (GO:0010758)4.29040352
62positive regulation of hemostasis (GO:1900048)4.20127929
63positive regulation of blood coagulation (GO:0030194)4.20127929
64omega-hydroxylase P450 pathway (GO:0097267)4.13676625
65S-adenosylmethionine metabolic process (GO:0046500)4.11405508
66amino-acid betaine metabolic process (GO:0006577)4.10915019
67acute-phase response (GO:0006953)4.08859556
68positive regulation of cell adhesion mediated by integrin (GO:0033630)4.04908735
69positive regulation of coagulation (GO:0050820)3.99469726
70cytokine production involved in immune response (GO:0002367)3.99118227
71arginine metabolic process (GO:0006525)3.97894034
72lymph node development (GO:0048535)3.97719331
73protein-lipid complex remodeling (GO:0034368)3.92440589
74macromolecular complex remodeling (GO:0034367)3.92440589
75plasma lipoprotein particle remodeling (GO:0034369)3.92440589
76serine family amino acid metabolic process (GO:0009069)3.91488889
77intestinal cholesterol absorption (GO:0030299)3.91007902
78imidazole-containing compound metabolic process (GO:0052803)3.87534424
79cellular extravasation (GO:0045123)3.86568270
80regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.79472352
81keratan sulfate catabolic process (GO:0042340)3.78624821
82tyrosine metabolic process (GO:0006570)3.77373490
83hormone catabolic process (GO:0042447)3.76731758
84positive regulation of endothelial cell apoptotic process (GO:2000353)3.76366488
85positive regulation of triglyceride lipase activity (GO:0061365)3.75248181
86positive regulation of lipoprotein lipase activity (GO:0051006)3.75248181
87negative regulation of lipase activity (GO:0060192)3.71567802
88regulation of phagocytosis (GO:0050764)3.68746772
89steroid catabolic process (GO:0006706)3.68134192
90flavonoid metabolic process (GO:0009812)3.66476080
91regulation of T cell migration (GO:2000404)3.66062358
92positive regulation of T cell chemotaxis (GO:0010820)3.63746985
93regulation of T cell chemotaxis (GO:0010819)3.63746985
94negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.62694245
95negative regulation of cell killing (GO:0031342)3.62694245
96regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.58890351
97indole-containing compound catabolic process (GO:0042436)3.54910462
98indolalkylamine catabolic process (GO:0046218)3.54910462
99tryptophan catabolic process (GO:0006569)3.54910462
100cholesterol efflux (GO:0033344)3.50793979
101alpha-amino acid catabolic process (GO:1901606)3.50557777
102regulation of cholesterol esterification (GO:0010872)3.49814887
103citrulline metabolic process (GO:0000052)3.48920341
104high-density lipoprotein particle remodeling (GO:0034375)3.45057752
105xenobiotic metabolic process (GO:0006805)3.44956385
106reverse cholesterol transport (GO:0043691)3.44793910
107heme transport (GO:0015886)3.43653864
108negative regulation of complement activation (GO:0045916)3.39808626
109aromatic amino acid family metabolic process (GO:0009072)3.38321373
110negative regulation of protein activation cascade (GO:2000258)3.37540454
111regulation of bile acid biosynthetic process (GO:0070857)3.37117371
112positive regulation of phagocytosis (GO:0050766)3.33473912
113leukotriene metabolic process (GO:0006691)3.33073145
114production of molecular mediator involved in inflammatory response (GO:0002532)3.30548829
115chronic inflammatory response (GO:0002544)3.29635831
116cellular ketone body metabolic process (GO:0046950)3.28806513
117polyketide metabolic process (GO:0030638)3.27679689
118doxorubicin metabolic process (GO:0044598)3.27679689
119daunorubicin metabolic process (GO:0044597)3.27679689
120acute inflammatory response (GO:0002526)3.27337304
121primary alcohol metabolic process (GO:0034308)3.26415722
122serine family amino acid biosynthetic process (GO:0009070)3.25680137
123production of molecular mediator of immune response (GO:0002440)3.24010400
124positive regulation of Rap GTPase activity (GO:0032854)3.22435126
125regulation of phospholipase A2 activity (GO:0032429)3.22220086
126glutamate metabolic process (GO:0006536)3.21031496
127negative regulation of granulocyte differentiation (GO:0030853)3.20866694
128positive regulation of lipid catabolic process (GO:0050996)3.20534213
129respiratory burst (GO:0045730)3.17672522
130cysteine metabolic process (GO:0006534)3.17136456
131negative regulation of interleukin-12 production (GO:0032695)3.16811887
132xenobiotic catabolic process (GO:0042178)3.15598219
133platelet degranulation (GO:0002576)3.14071508
134regulation of acute inflammatory response (GO:0002673)3.14015749
135collagen fibril organization (GO:0030199)3.12498700
136arachidonic acid metabolic process (GO:0019369)3.07628769
137fatty acid derivative biosynthetic process (GO:1901570)3.06726117
138icosanoid biosynthetic process (GO:0046456)3.06726117
139negative regulation of fibrinolysis (GO:0051918)3.05597869
140phosphatidylethanolamine biosynthetic process (GO:0006646)3.03404976
141mesenchymal-epithelial cell signaling (GO:0060638)3.00509910
142activated T cell proliferation (GO:0050798)2.98926231
143plasma lipoprotein particle clearance (GO:0034381)2.98832168
144detection of external biotic stimulus (GO:0098581)2.97358712
145positive regulation of extracellular matrix organization (GO:1903055)2.93995549
146prostaglandin metabolic process (GO:0006693)2.90078048
147prostanoid metabolic process (GO:0006692)2.90078048
148regulation of lymphocyte migration (GO:2000401)2.89105511
149regulation of mononuclear cell migration (GO:0071675)2.88158371
150positive regulation of fatty acid biosynthetic process (GO:0045723)2.85212400
151cyclooxygenase pathway (GO:0019371)2.82223234
152triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.81857374
153fibrinolysis (GO:0042730)2.78515725
154peptidyl-proline hydroxylation (GO:0019511)2.77869045
155phosphatidylethanolamine metabolic process (GO:0046337)2.77534336
156phagocytosis (GO:0006909)2.77028300
157regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.76906940
158unsaturated fatty acid biosynthetic process (GO:0006636)2.74532232
159regulation of Rap GTPase activity (GO:0032317)2.68777991
160cytoskeletal anchoring at plasma membrane (GO:0007016)2.66411334
161alpha-linolenic acid metabolic process (GO:0036109)2.63884828
162regulation of cholesterol storage (GO:0010885)2.63878190
163fibril organization (GO:0097435)2.62699440
164endothelial cell morphogenesis (GO:0001886)2.61884879
165regulation of cell adhesion mediated by integrin (GO:0033628)2.61867628
166regulation of dendritic cell antigen processing and presentation (GO:0002604)2.60978112
167negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.60186361
168positive regulation of osteoblast proliferation (GO:0033690)2.59352787
169hyaluronan catabolic process (GO:0030214)2.59001781
170basement membrane organization (GO:0071711)2.58964093
171negative regulation of humoral immune response (GO:0002921)2.56110861
172nitric oxide biosynthetic process (GO:0006809)2.55252194
173cell adhesion mediated by integrin (GO:0033627)2.53845568
174regulation of fibrinolysis (GO:0051917)2.53450413
175regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.53032680
176phospholipid efflux (GO:0033700)2.52115711
177regulation of apoptotic cell clearance (GO:2000425)10.0577643

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse4.81890959
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.50044255
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.16660491
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.91358370
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.53193856
6RXR_22158963_ChIP-Seq_LIVER_Mouse3.51824334
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.02915378
8ESR1_15608294_ChIP-ChIP_MCF-7_Human2.98796433
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.82426474
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.80257553
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.63888527
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.55117774
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.53819877
14* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.22921215
15TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.18690352
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.18038735
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.16121615
18CLOCK_20551151_ChIP-Seq_293T_Human2.07233874
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98430616
20* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.95783618
21RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.94905619
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.93896859
23HTT_18923047_ChIP-ChIP_STHdh_Human1.84184586
24MYB_21317192_ChIP-Seq_ERMYB_Mouse1.83256472
25ELK3_25401928_ChIP-Seq_HUVEC_Human1.82877661
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76428616
27LXR_22292898_ChIP-Seq_THP-1_Human1.74973354
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.72883657
29PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.70895793
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.70830719
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.69298196
32BCAT_22108803_ChIP-Seq_LS180_Human1.67795859
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.64913590
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.63720828
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63720218
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62073695
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.60572702
38FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.59301607
39NRF2_20460467_ChIP-Seq_MEFs_Mouse1.54922955
40NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.54922955
41* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.52273709
42MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.52132128
43HNF4A_19822575_ChIP-Seq_HepG2_Human1.50599656
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49987718
45ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.49468764
46HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.45592835
47TP53_16413492_ChIP-PET_HCT116_Human1.44174016
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42437749
49TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.41569947
50ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39608144
51ESR1_21235772_ChIP-Seq_MCF-7_Human1.39392499
52CJUN_26792858_Chip-Seq_BT549_Human1.39381923
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37850877
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36968024
55BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.33133292
56GBX2_23144817_ChIP-Seq_PC3_Human1.31094235
57* NFE2_27457419_Chip-Seq_LIVER_Mouse1.30960809
58* EZH2_27294783_Chip-Seq_NPCs_Mouse1.30679306
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28508874
60WT1_19549856_ChIP-ChIP_CCG9911_Human1.27899884
61RACK7_27058665_Chip-Seq_MCF-7_Human1.27531073
62SPI1_23127762_ChIP-Seq_K562_Human1.26216271
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25688022
64IRF8_22096565_ChIP-ChIP_GC-B_Human1.24412292
65FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.23837772
66SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20401180
67CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.20015542
68* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18286825
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18216435
70TP53_18474530_ChIP-ChIP_U2OS_Human1.14266092
71UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13335171
72GATA2_21666600_ChIP-Seq_HMVEC_Human1.13044074
73ER_23166858_ChIP-Seq_MCF-7_Human1.12574352
74NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11777733
75KDM2B_26808549_Chip-Seq_DND41_Human1.11538510
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11279457
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10028866
78EP300_21415370_ChIP-Seq_HL-1_Mouse1.09557586
79ESR1_20079471_ChIP-ChIP_T-47D_Human1.09298880
80TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08330912
81TCF4_18268006_ChIP-ChIP_LS174T_Human1.08177170
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07124655
83* PHF8_20622853_ChIP-Seq_HELA_Human1.06783078
84* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.06150841
85* HNFA_21074721_ChIP-Seq_CACO-2_Human1.05877419
86RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05208797
87AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.03890198
88E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03480224
89VDR_24763502_ChIP-Seq_THP-1_Human1.01933037
90CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01463482
91* NFYA_21822215_ChIP-Seq_K562_Human1.00277468
92WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99771768
93* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99054613
94EED_16625203_ChIP-ChIP_MESCs_Mouse0.98875571
95SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.98356486
96SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98095928
97TP53_22127205_ChIP-Seq_IMR90_Human0.96641299
98PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96494947
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96337140
100STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.95590355
101SOX2_20726797_ChIP-Seq_SW620_Human0.95286023
102* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95154574
103* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94399991
104CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93779901
105PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93229518
106* CRX_20693478_ChIP-Seq_RETINA_Mouse0.92921106
107DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92604505
108* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92569420
109SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92239562
110GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91657581
111VDR_21846776_ChIP-Seq_THP-1_Human0.91324874
112CDX2_22108803_ChIP-Seq_LS180_Human0.91145742
113FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.90791343
114P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90653343
115* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.90409743
116SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.90310580
117KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90200378
118ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90137530
119ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90098976
120* ETV1_20927104_ChIP-Seq_GIST48_Human0.90032319
121* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.89433070
122* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89051647
123* CBX2_22325352_ChIP-Seq_293T-Rex_Human0.88973910
124GATA2_19941826_ChIP-Seq_K562_Human0.88288048
125MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.87563190
126CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87553961
127TCF7_22412390_ChIP-Seq_EML_Mouse0.87289760
128* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.87099373
129P63_26484246_Chip-Seq_KERATINOCYTES_Human0.87069540
130* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.86538022
131CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86460444
132* NANOG_18555785_Chip-Seq_ESCs_Mouse0.85595592
133AR_20517297_ChIP-Seq_VCAP_Human0.85322878
134TCF4_22108803_ChIP-Seq_LS180_Human0.84807422
135KDM2B_26808549_Chip-Seq_K562_Human0.84797266
136STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.84674498
137PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.84613987
138VDR_24787735_ChIP-Seq_THP-1_Human0.84264812
139SMAD3_21741376_ChIP-Seq_EPCs_Human0.84013336
140RUNX_20019798_ChIP-Seq_JUKART_Human0.83624596
141* P53_22387025_ChIP-Seq_ESCs_Mouse0.83271526
142IRF1_19129219_ChIP-ChIP_H3396_Human0.83061065
143PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82934371
144* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.82836684
145* GATA6_21074721_ChIP-Seq_CACO-2_Human0.82803893
146FOXA2_19822575_ChIP-Seq_HepG2_Human0.82731388
147PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.81974718
148GATA1_19941827_ChIP-Seq_MEL_Mouse0.81138218
149TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.80942735
150* STAT3_18555785_Chip-Seq_ESCs_Mouse0.80384094
151* NFYB_21822215_ChIP-Seq_K562_Human0.80081156
152CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80062579
153SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.79987227
154ZFP281_18757296_ChIP-ChIP_E14_Mouse0.79837190
155* TBL1_22424771_ChIP-Seq_293T_Human0.78587567
156SPI1_20517297_ChIP-Seq_HL60_Human0.78341709
157CTBP2_25329375_ChIP-Seq_LNCAP_Human0.78201141
158SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.78166076
159* RBPJ_21746931_ChIP-Seq_IB4_Human0.78141432
160GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78013577
161SMC3_22415368_ChIP-Seq_MEFs_Mouse0.77825203
162TAF15_26573619_Chip-Seq_HEK293_Human0.77533830
163TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77501158
164KDM2B_26808549_Chip-Seq_JURKAT_Human0.77181907
165NR3C1_23031785_ChIP-Seq_PC12_Mouse0.76929104
166SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.76731396
167PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75450681
168* OCT4_18555785_Chip-Seq_ESCs_Mouse0.74952803
169SMAD4_21799915_ChIP-Seq_A2780_Human0.74638438
170SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.74528389
171* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.73951566
172ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.73752631
173CBP_21632823_ChIP-Seq_H3396_Human0.73686909
174CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.73361184
175* E2F1_18555785_Chip-Seq_ESCs_Mouse0.73138116
176CBX2_27304074_Chip-Seq_ESCs_Mouse0.72983698
177* ESRRB_18555785_Chip-Seq_ESCs_Mouse0.70528944

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog7.27438030
2MP0008438_abnormal_cutaneous_collagen7.23698611
3MP0003195_calcinosis5.19660889
4MP0009384_cardiac_valve_regurgitation4.88337275
5MP0003279_aneurysm4.39263284
6MP0002138_abnormal_hepatobiliary_system4.33216974
7MP0001958_emphysema4.20598389
8MP0003724_increased_susceptibility_to4.12705122
9MP0005275_abnormal_skin_tensile4.03700059
10MP0003868_abnormal_feces_composition3.64719314
11MP0001666_abnormal_nutrient_absorption3.08659545
12MP0003436_decreased_susceptibility_to2.74815760
13MP0009840_abnormal_foam_cell2.73502606
14MP0009697_abnormal_copulation2.68870735
15MP0005058_abnormal_lysosome_morphology2.66182219
16MP0002876_abnormal_thyroid_physiology2.46160726
17MP0005503_abnormal_tendon_morphology2.33158343
18MP0002933_joint_inflammation2.24550528
19MP0010368_abnormal_lymphatic_system2.23540199
20* MP0001533_abnormal_skeleton_physiology2.05541299
21MP0005360_urolithiasis1.85237236
22MP0003075_altered_response_to1.79036874
23MP0000767_abnormal_smooth_muscle1.72732331
24MP0001790_abnormal_immune_system1.70026498
25MP0005387_immune_system_phenotype1.70026498
26MP0005023_abnormal_wound_healing1.68984414
27MP0004019_abnormal_vitamin_homeostasis1.67375000
28MP0003806_abnormal_nucleotide_metabolis1.56370938
29MP0002419_abnormal_innate_immunity1.50392723
30MP0000604_amyloidosis1.48170912
31MP0002295_abnormal_pulmonary_circulatio1.47110746
32MP0000685_abnormal_immune_system1.45848196
33MP0001851_eye_inflammation1.45196327
34MP0002108_abnormal_muscle_morphology1.38317215
35MP0002168_other_aberrant_phenotype1.37781293
36* MP0005390_skeleton_phenotype1.34555439
37MP0001764_abnormal_homeostasis1.29286403
38MP0003303_peritoneal_inflammation1.28423449
39MP0005000_abnormal_immune_tolerance1.27839643
40MP0002139_abnormal_hepatobiliary_system1.27541241
41MP0002060_abnormal_skin_morphology1.25093106
42MP0004272_abnormal_basement_membrane1.25007029
43MP0001879_abnormal_lymphatic_vessel1.24925545
44MP0005025_abnormal_response_to1.24473705
45MP0005670_abnormal_white_adipose1.21693262
46MP0004947_skin_inflammation1.18983605
47MP0003566_abnormal_cell_adhesion1.17743218
48MP0010386_abnormal_urinary_bladder1.17686086
49MP0001661_extended_life_span1.17021749
50MP0005408_hypopigmentation1.15739768
51MP0000249_abnormal_blood_vessel1.14711104
52MP0003186_abnormal_redox_activity1.11969718
53MP0004233_abnormal_muscle_weight1.11320052
54MP0003329_amyloid_beta_deposits1.09614739
55MP0009053_abnormal_anal_canal1.08994080
56MP0009333_abnormal_splenocyte_physiolog1.08478673
57MP0003191_abnormal_cellular_cholesterol1.06965517
58MP0005187_abnormal_penis_morphology1.06935096
59MP0003091_abnormal_cell_migration1.05100857
60MP0005365_abnormal_bile_salt1.04889259
61MP0002148_abnormal_hypersensitivity_rea1.03722567
62MP0001915_intracranial_hemorrhage1.01750949
63MP0006054_spinal_hemorrhage0.99129335
64MP0003011_delayed_dark_adaptation0.97694575
65MP0002971_abnormal_brown_adipose0.96801369
66MP0008004_abnormal_stomach_pH0.96235095
67MP0005464_abnormal_platelet_physiology0.95253488
68MP0010329_abnormal_lipoprotein_level0.94432516
69MP0000343_altered_response_to0.93405254
70MP0002166_altered_tumor_susceptibility0.92672405
71MP0009643_abnormal_urine_homeostasis0.90109111
72MP0003252_abnormal_bile_duct0.89327741
73MP0003646_muscle_fatigue0.88897353
74MP0009763_increased_sensitivity_to0.87728435
75MP0002405_respiratory_system_inflammati0.87591261
76MP0008875_abnormal_xenobiotic_pharmacok0.86766255
77MP0005388_respiratory_system_phenotype0.86746380
78MP0002133_abnormal_respiratory_system0.86746380
79MP0005085_abnormal_gallbladder_physiolo0.85796362
80MP0001800_abnormal_humoral_immune0.85690142
81MP0005319_abnormal_enzyme/_coenzyme0.85284205
82MP0002998_abnormal_bone_remodeling0.83058911
83MP0005165_increased_susceptibility_to0.82624417
84MP0001849_ear_inflammation0.82552676
85MP0002452_abnormal_antigen_presenting0.80432616
86MP0001542_abnormal_bone_strength0.79823778
87MP0000566_synostosis0.79789684
88MP0002128_abnormal_blood_circulation0.79226585
89MP0005508_abnormal_skeleton_morphology0.77827711
90MP0003300_gastrointestinal_ulcer0.77804341
91MP0005535_abnormal_body_temperature0.77767799
92MP0002282_abnormal_trachea_morphology0.76693451
93MP0003690_abnormal_glial_cell0.75513747
94MP0005166_decreased_susceptibility_to0.75042203
95MP0005197_abnormal_uvea_morphology0.74509675
96MP0002909_abnormal_adrenal_gland0.73986175
97MP0001845_abnormal_inflammatory_respons0.73883916
98MP0005332_abnormal_amino_acid0.73608281
99MP0001614_abnormal_blood_vessel0.72915334
100MP0003656_abnormal_erythrocyte_physiolo0.72327463
101MP0003172_abnormal_lysosome_physiology0.72283529
102MP0005595_abnormal_vascular_smooth0.70651556
103MP0005376_homeostasis/metabolism_phenot0.70569270
104MP0000609_abnormal_liver_physiology0.69397692
105MP0001243_abnormal_dermal_layer0.69289436
106MP0003448_altered_tumor_morphology0.68141778
107MP0009642_abnormal_blood_homeostasis0.67963844
108MP0004510_myositis0.67512483
109MP0005584_abnormal_enzyme/coenzyme_acti0.65424452
110MP0008469_abnormal_protein_level0.65411137
111MP0002132_abnormal_respiratory_system0.64089319
112MP0009931_abnormal_skin_appearance0.62802664
113MP0002078_abnormal_glucose_homeostasis0.62614726
114MP0005395_other_phenotype0.60677741
115MP0005083_abnormal_biliary_tract0.59196424
116MP0002118_abnormal_lipid_homeostasis0.57637197
117MP0002723_abnormal_immune_serum0.56864194
118MP0002090_abnormal_vision0.56562428
119MP0000598_abnormal_liver_morphology0.55602598
120MP0003879_abnormal_hair_cell0.55164423
121MP0002420_abnormal_adaptive_immunity0.55064427
122MP0001177_atelectasis0.54899973
123MP0004134_abnormal_chest_morphology0.54646188
124MP0003638_abnormal_response/metabolism_0.54107153
125MP0002136_abnormal_kidney_physiology0.53935820
126MP0000689_abnormal_spleen_morphology0.53693943
127MP0000751_myopathy0.53273520
128MP0002135_abnormal_kidney_morphology0.53094222
129MP0001819_abnormal_immune_cell0.53065509
130MP0003795_abnormal_bone_structure0.52905287
131MP0000858_altered_metastatic_potential0.52825715
132MP0005220_abnormal_exocrine_pancreas0.52005704
133MP0002928_abnormal_bile_duct0.51311371
134MP0005164_abnormal_response_to0.50644058
135MP0005266_abnormal_metabolism0.49733717
136MP0005636_abnormal_mineral_homeostasis0.49605097
137MP0002249_abnormal_larynx_morphology0.48655294
138MP0005448_abnormal_energy_balance0.47324918
139MP0009379_abnormal_foot_pigmentation0.45011596
140MP0001756_abnormal_urination0.44797451
141MP0005084_abnormal_gallbladder_morpholo0.44688238
142MP0005334_abnormal_fat_pad0.44374820
143MP0009764_decreased_sensitivity_to0.42632877
144MP0001944_abnormal_pancreas_morphology0.39584914
145MP0005257_abnormal_intraocular_pressure0.39110235
146MP0004130_abnormal_muscle_cell0.36857884
147MP0008775_abnormal_heart_ventricle0.36504698
148MP0008872_abnormal_physiological_respon0.34855234
149MP0004883_abnormal_blood_vessel0.34797474
150MP0004142_abnormal_muscle_tone0.34400453
151MP0002837_dystrophic_cardiac_calcinosis0.33831651
152MP0009115_abnormal_fat_cell0.33620637
153MP0003953_abnormal_hormone_level0.33229244
154MP0003959_abnormal_lean_body0.33139223
155MP0003941_abnormal_skin_development0.33004069

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)9.03872002
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.61536979
3Arterial tortuosity (HP:0005116)6.90284938
4Vascular tortuosity (HP:0004948)6.62504172
5Hypobetalipoproteinemia (HP:0003563)6.53289271
6Glomerulonephritis (HP:0000099)5.91661642
7Complement deficiency (HP:0004431)5.69959274
8Abnormality of complement system (HP:0005339)5.64272759
9Hyperlipoproteinemia (HP:0010980)5.46047799
10Aortic aneurysm (HP:0004942)5.45983972
11Shallow orbits (HP:0000586)5.32485901
12Conjugated hyperbilirubinemia (HP:0002908)5.26053009
13Peritonitis (HP:0002586)5.15236935
14Intrahepatic cholestasis (HP:0001406)4.79080152
15Dysostosis multiplex (HP:0000943)4.73594639
16Deep venous thrombosis (HP:0002625)4.53528710
17Spondylolisthesis (HP:0003302)4.49280486
18Protrusio acetabuli (HP:0003179)4.35197557
19Abnormality of pyrimidine metabolism (HP:0004353)4.15789295
20Vacuolated lymphocytes (HP:0001922)4.12431787
21Overgrowth (HP:0001548)4.09462800
22Hypolipoproteinemia (HP:0010981)4.06719823
23Abnormality of the intrinsic pathway (HP:0010989)3.97390231
24Mucopolysacchariduria (HP:0008155)3.91198403
25Urinary glycosaminoglycan excretion (HP:0003541)3.91198403
26Recurrent gram-negative bacterial infections (HP:0005420)3.76122432
27Nephritis (HP:0000123)3.73967954
28Cervical subluxation (HP:0003308)3.63979048
29Soft skin (HP:0000977)3.55897829
30Abnormality of mucopolysaccharide metabolism (HP:0011020)3.55789858
31Abnormality of polysaccharide metabolism (HP:0011012)3.55789858
32Abnormality of glycosaminoglycan metabolism (HP:0004371)3.55789858
33Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.52384270
34Spontaneous abortion (HP:0005268)3.51858333
35Asymmetric septal hypertrophy (HP:0001670)3.48437340
36Broad metatarsal (HP:0001783)3.42526470
37Cerebral aneurysm (HP:0004944)3.40710089
38Abnormality of the common coagulation pathway (HP:0010990)3.39096875
39Prolonged partial thromboplastin time (HP:0003645)3.36130509
40Cardiovascular calcification (HP:0011915)3.35521609
41Bladder diverticulum (HP:0000015)3.29330845
42Premature rupture of membranes (HP:0001788)3.22821692
43Hypoalphalipoproteinemia (HP:0003233)3.22330054
44Vertebral compression fractures (HP:0002953)3.20706651
45Osteomalacia (HP:0002749)3.20345335
46Hyperglycinemia (HP:0002154)3.19082110
47J-shaped sella turcica (HP:0002680)3.18182184
48Hand muscle atrophy (HP:0009130)3.16618830
49Mitral stenosis (HP:0001718)3.11344392
50Wormian bones (HP:0002645)3.10269407
51Generalized aminoaciduria (HP:0002909)3.09298820
52Abnormality of glutamine family amino acid metabolism (HP:0010902)3.07566919
53Loss of speech (HP:0002371)3.07388144
54Delayed CNS myelination (HP:0002188)3.03671162
55Vascular calcification (HP:0004934)3.02209602
56Fat malabsorption (HP:0002630)2.95209653
57Dilatation of the ascending aorta (HP:0005111)2.94515630
58Beaking of vertebral bodies (HP:0004568)2.92361401
59Pustule (HP:0200039)2.89087752
60Aneurysm (HP:0002617)2.84844035
61Reduced antithrombin III activity (HP:0001976)2.84124838
62Menorrhagia (HP:0000132)2.80903618
63Short nail (HP:0001799)2.76175395
64Distal upper limb amyotrophy (HP:0007149)2.67541244
65Upper limb amyotrophy (HP:0009129)2.67541244
66* Joint stiffness (HP:0001387)2.66669961
67Nasal polyposis (HP:0100582)2.66344225
68Hyperphosphaturia (HP:0003109)2.62956456
69Hyperammonemia (HP:0001987)2.62021838
70Abnormality of methionine metabolism (HP:0010901)2.61384779
71Abnormality of the lumbar spine (HP:0100712)2.59698285
72Abnormality of the nasal mucosa (HP:0000433)2.52619690
73Aortic dissection (HP:0002647)2.51307131
74Rickets (HP:0002748)2.49611164
75Epidermoid cyst (HP:0200040)2.49267278
76Bronchomalacia (HP:0002780)2.45837177
77Xanthomatosis (HP:0000991)2.45619925
78Steatorrhea (HP:0002570)2.44788307
79Ovoid vertebral bodies (HP:0003300)2.43843091
80Abnormality of serum amino acid levels (HP:0003112)2.42465734
81Abnormality of nucleobase metabolism (HP:0010932)2.40458830
82Bowel diverticulosis (HP:0005222)2.40415484
83Deformed sella turcica (HP:0002681)2.39648119
84Recurrent abscess formation (HP:0002722)2.36148223
85Glycosuria (HP:0003076)2.32704937
86Abnormality of urine glucose concentration (HP:0011016)2.32704937
87Abnormality of glycine metabolism (HP:0010895)2.30683139
88Abnormality of serine family amino acid metabolism (HP:0010894)2.30683139
89Eczematoid dermatitis (HP:0000976)2.30335603
90Fair hair (HP:0002286)2.24192855
91Joint hemorrhage (HP:0005261)2.20384094
92Polygenic inheritance (HP:0010982)2.19934127
93Coarse hair (HP:0002208)2.16633910
94Neurofibrillary tangles (HP:0002185)2.16379218
95Gastrointestinal infarctions (HP:0005244)2.14512462
96Abnormality of aspartate family amino acid metabolism (HP:0010899)2.11307125
97Thoracic kyphosis (HP:0002942)2.09544482
98Hypercholesterolemia (HP:0003124)2.07483347
99Abnormality of the peritoneum (HP:0002585)2.06845172
100Gingival bleeding (HP:0000225)2.05460950
101Hyperbilirubinemia (HP:0002904)2.05378096
102Decreased subcutaneous fat (HP:0001002)2.05112950
103Abnormal urine phosphate concentration (HP:0012599)2.04968699
104Emphysema (HP:0002097)2.02861939
105Abnormality of vitamin metabolism (HP:0100508)2.01377862
106Metabolic acidosis (HP:0001942)2.00691021
107Hepatocellular carcinoma (HP:0001402)2.00624880
108Fragile skin (HP:0001030)1.99437697
109Amyloidosis (HP:0011034)1.98651083
110Atrophic scars (HP:0001075)1.98265391
111Turricephaly (HP:0000262)1.98238296
112Opisthotonus (HP:0002179)1.94825967
113Neonatal hypoglycemia (HP:0001998)1.92179954
114Hypoplasia of the odontoid process (HP:0003311)1.91161439
115Abnormal biliary tract physiology (HP:0012439)1.90223824
116Bile duct proliferation (HP:0001408)1.90223824
117Biconcave vertebral bodies (HP:0004586)1.90029965
118Abnormality of sulfur amino acid metabolism (HP:0004339)1.89287893
119Abnormality of skull ossification (HP:0002703)1.88719443
120Irritability (HP:0000737)1.87803312
121Hyperglycinuria (HP:0003108)1.87272640
122Broad face (HP:0000283)1.87229084
123Bradycardia (HP:0001662)1.87042167
124Flat acetabular roof (HP:0003180)1.84787107
125Striae distensae (HP:0001065)1.83301807
126Abnormality of the acetabulum (HP:0003170)1.82973163
127Toxemia of pregnancy (HP:0100603)1.82383715
128Abnormality of monocarboxylic acid metabolism (HP:0010996)1.81436913
129Blue sclerae (HP:0000592)1.81399644
130Cerebral inclusion bodies (HP:0100314)1.78585131
131Pulmonary embolism (HP:0002204)1.78074735
132Periodontitis (HP:0000704)1.76892733
133Atrioventricular block (HP:0001678)1.76704190
134Ketosis (HP:0001946)1.76384070
135Hypochromic microcytic anemia (HP:0004840)1.75082573
136Skin nodule (HP:0200036)1.74490239
137Abnormality of the Achilles tendon (HP:0005109)1.74327110
138Esophageal varix (HP:0002040)1.73790647
139Mitral valve prolapse (HP:0001634)1.73594054
140Enlarged penis (HP:0000040)1.72084209
141Atelectasis (HP:0100750)1.72014175
142Purpura (HP:0000979)1.71716538
143Multifactorial inheritance (HP:0001426)1.71412446
144Severe short stature (HP:0003510)1.71139740
145Abnormal delivery (HP:0001787)1.70515069
146Abnormality of the odontoid process (HP:0003310)1.69658317
147Gingivitis (HP:0000230)1.69547294
148Vertebral hypoplasia (HP:0008417)1.69052967
149Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.69052967
150Arachnodactyly (HP:0001166)1.68671184
151Recurrent bacterial skin infections (HP:0005406)1.68125198
152Cerebral edema (HP:0002181)1.67687820
153Retinal atrophy (HP:0001105)1.67112618
154Ectopia lentis (HP:0001083)1.66221302
155Prolonged bleeding time (HP:0003010)1.65981019
156Abnormal sex determination (HP:0012244)1.65311564
157Sex reversal (HP:0012245)1.65311564
158Hemorrhage of the eye (HP:0011885)1.64031651
159Facial shape deformation (HP:0011334)1.62396984
160Potter facies (HP:0002009)1.62396984
161Episodic fever (HP:0001954)1.62131489
162Inguinal hernia (HP:0000023)1.60873470
163Abnormality of purine metabolism (HP:0004352)1.60099034
164Thrombophlebitis (HP:0004418)1.59726471
165Pathologic fracture (HP:0002756)1.59009584
166Myocardial infarction (HP:0001658)1.58590259
167Generalized hypopigmentation of hair (HP:0011358)1.50450292
168Lethargy (HP:0001254)1.48450449
169* Arthropathy (HP:0003040)1.47686362
170Hypoglycemic coma (HP:0001325)1.47493027
171Hypophosphatemic rickets (HP:0004912)1.46384094
172Submucous cleft hard palate (HP:0000176)1.45008290
173Abnormal gallbladder morphology (HP:0012437)1.43156922
174Abnormality of iron homeostasis (HP:0011031)1.40943099
175Mesomelia (HP:0003027)1.40149877
176Increased serum ferritin (HP:0003281)1.39701967
177Elevated alkaline phosphatase (HP:0003155)1.38691116
178Torticollis (HP:0000473)1.38109746

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R6.77574478
2ERN16.46918982
3MET3.09569966
4PNCK3.00175818
5NLK3.00045711
6CAMK1D2.81477318
7RIPK12.78239028
8BLK2.74355783
9TRIB32.70265652
10DAPK22.51434391
11STK162.38768186
12TAOK32.30881370
13EPHB12.27134737
14PKN22.23460771
15MYLK2.18343908
16CAMK1G2.18223890
17FRK2.09748243
18AKT31.99492053
19NTRK31.94583968
20BMX1.92729459
21TTN1.87888454
22MAPK151.84614193
23ABL21.82105141
24MUSK1.76457595
25MAP4K11.75505502
26TNIK1.75254363
27MAP3K31.73887375
28WNK31.71086322
29GRK11.68657009
30INSRR1.67462441
31TGFBR21.61579144
32PRKCG1.55732259
33DYRK21.54130445
34TAF11.52710468
35LATS11.49453237
36PIK3CA1.45287833
37TYK21.39628650
38MAP3K111.37658160
39TIE11.35956438
40PRKCE1.34889924
41MAP3K131.34435291
42CAMK11.33661502
43EPHB21.31038626
44IRAK11.27144068
45PINK11.26226250
46CAMKK21.26011549
47PTK61.25121339
48FES1.24225898
49CASK1.24095223
50SGK2231.24057668
51SGK4941.24057668
52PRKG11.22235905
53FGFR31.21055987
54NTRK11.20378766
55SGK21.19790125
56LATS21.19466812
57PRKAA21.18634885
58FGR1.16249125
59PRKCH1.14778432
60GRK61.13818981
61EPHA31.07946315
62CAMKK11.07457625
63WNK11.07008295
64MAP2K31.06591358
65TEC0.98879530
66DAPK10.98838748
67HCK0.97059682
68FGFR40.96705500
69CSK0.95554110
70ACVR1B0.94817262
71ADRBK20.93474801
72LRRK20.92862544
73ERBB40.92411252
74MAPKAPK30.91912086
75PDGFRA0.90740144
76STK100.89559556
77PTK2B0.87695494
78TBK10.86175623
79ZAP700.85536927
80FGFR10.85438419
81HIPK20.85095983
82PTK20.85095599
83OBSCN0.84341226
84PRKACA0.82137763
85MAPK120.79242315
86BCKDK0.78401530
87MAP3K70.78023871
88PDGFRB0.77573684
89RPS6KA40.76849270
90BMPR1B0.75685055
91KIT0.74946498
92UHMK10.71086057
93JAK30.68982322
94FLT30.68539993
95IGF1R0.67565480
96DAPK30.67275078
97TRPM70.66890513
98SIK20.66426186
99FER0.65564783
100SIK10.65005641
101JAK10.63841180
102EPHA40.63818215
103RIPK40.62872277
104STK30.61571301
105EPHA20.58946495
106MAP3K120.58017942
107PRKACB0.57968227
108DYRK30.57761654
109LCK0.56021874
110RPS6KA20.55177091
111ADRBK10.55060774
112SGK10.51423104
113FYN0.51058191
114MAP3K10.50372880
115GRK50.49622643
116MARK30.49365972
117EGFR0.49143235
118LIMK10.47766296
119MAP2K40.47666332
120CSNK1D0.47503443
121PRKCA0.47050569
122MAP3K60.47045462
123MAP2K10.46912939
124FGFR20.46558486
125PRKAA10.45813768
126BTK0.45723821
127DDR20.45385630
128MOS0.44690008
129CSF1R0.43369618
130MARK10.42480140
131STK380.42369289
132CAMK2D0.41708184
133STK38L0.41086092
134IRAK40.40530722
135PRKCZ0.39633709
136RPS6KA30.39383360
137RPS6KL10.38728766
138RPS6KC10.38728766
139JAK20.38726604
140RPS6KA60.38448812
141SGK30.37675577
142CSNK1E0.34720891
143RET0.34535181
144CDC42BPA0.34424491
145PDPK10.33938784
146DYRK1A0.32521551
147ERBB30.32475663
148TGFBR10.32446090
149ERBB20.31006203
150PAK30.30506579
151CAMK40.30241843
152MAPK40.30127457
153SYK0.29399262
154PIK3CG0.28984286
155GSK3A0.27802764
156MAPK70.27404630
157MAP3K90.26521632
158MAP3K100.26508750
159SRC0.26243794
160NEK90.25101861
161TAOK10.25003054
162PRKD10.24701037
163MATK0.24002192
164MAPKAPK20.22071371
165PRKACG0.22032348
166PIM20.21686503

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051506.93498425
2Complement and coagulation cascades_Homo sapiens_hsa046104.92540713
3Other glycan degradation_Homo sapiens_hsa005114.84630153
4Caffeine metabolism_Homo sapiens_hsa002323.55550524
5Glycosaminoglycan degradation_Homo sapiens_hsa005313.37232779
6Pertussis_Homo sapiens_hsa051332.43859207
7Nitrogen metabolism_Homo sapiens_hsa009102.36053880
8Tyrosine metabolism_Homo sapiens_hsa003502.14984108
9Malaria_Homo sapiens_hsa051442.09213495
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.91433592
11Prion diseases_Homo sapiens_hsa050201.86989987
12Primary bile acid biosynthesis_Homo sapiens_hsa001201.84820212
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.80524631
14Lysosome_Homo sapiens_hsa041421.78836616
15Pentose and glucuronate interconversions_Homo sapiens_hsa000401.72994351
16Arachidonic acid metabolism_Homo sapiens_hsa005901.68653343
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.64552845
18Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.64417669
19Linoleic acid metabolism_Homo sapiens_hsa005911.45259719
20Leishmaniasis_Homo sapiens_hsa051401.35847179
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27096799
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23713968
23Arginine biosynthesis_Homo sapiens_hsa002201.16605395
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.12901999
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.12866809
26Histidine metabolism_Homo sapiens_hsa003401.12391336
27Phagosome_Homo sapiens_hsa041451.12006361
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.11254836
29Tryptophan metabolism_Homo sapiens_hsa003801.09970870
30Amoebiasis_Homo sapiens_hsa051461.07940754
31Vitamin B6 metabolism_Homo sapiens_hsa007501.05995687
32Starch and sucrose metabolism_Homo sapiens_hsa005001.03831344
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.01908817
34Chemical carcinogenesis_Homo sapiens_hsa052040.98173482
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97017527
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94721950
37Fat digestion and absorption_Homo sapiens_hsa049750.88867612
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86100525
39Fatty acid degradation_Homo sapiens_hsa000710.80998630
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80888743
41Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80177980
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78127836
43ECM-receptor interaction_Homo sapiens_hsa045120.74745495
44Legionellosis_Homo sapiens_hsa051340.74291921
45Hematopoietic cell lineage_Homo sapiens_hsa046400.74288015
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73288551
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71917325
48Bile secretion_Homo sapiens_hsa049760.68218112
49Proteoglycans in cancer_Homo sapiens_hsa052050.66931736
50Osteoclast differentiation_Homo sapiens_hsa043800.66557829
51PPAR signaling pathway_Homo sapiens_hsa033200.66503606
52One carbon pool by folate_Homo sapiens_hsa006700.66332623
53Tuberculosis_Homo sapiens_hsa051520.66146223
54Chemokine signaling pathway_Homo sapiens_hsa040620.65097862
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64997973
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.64787519
57Focal adhesion_Homo sapiens_hsa045100.64682321
58Platelet activation_Homo sapiens_hsa046110.62545433
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.62387100
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62010441
61Peroxisome_Homo sapiens_hsa041460.60630495
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58883813
63Galactose metabolism_Homo sapiens_hsa000520.58623613
64Fatty acid metabolism_Homo sapiens_hsa012120.58287113
65ABC transporters_Homo sapiens_hsa020100.57877293
66beta-Alanine metabolism_Homo sapiens_hsa004100.56239688
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.55441100
68Shigellosis_Homo sapiens_hsa051310.55333055
69Carbon metabolism_Homo sapiens_hsa012000.53815429
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53754939
71Lysine degradation_Homo sapiens_hsa003100.52644743
72Rap1 signaling pathway_Homo sapiens_hsa040150.50527461
73Viral myocarditis_Homo sapiens_hsa054160.49886611
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49656983
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47874659
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47839384
77Sulfur relay system_Homo sapiens_hsa041220.46859085
78Metabolic pathways_Homo sapiens_hsa011000.45243287
79Toxoplasmosis_Homo sapiens_hsa051450.44638333
80N-Glycan biosynthesis_Homo sapiens_hsa005100.43948286
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42506545
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42313119
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42128291
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41613241
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41193340
86Phenylalanine metabolism_Homo sapiens_hsa003600.37808468
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.37738736
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36589543
89Salmonella infection_Homo sapiens_hsa051320.36268260
90Sulfur metabolism_Homo sapiens_hsa009200.35631697
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31981837
92Glycerolipid metabolism_Homo sapiens_hsa005610.31679361
93Arginine and proline metabolism_Homo sapiens_hsa003300.31666489
94Folate biosynthesis_Homo sapiens_hsa007900.31252556
95Butanoate metabolism_Homo sapiens_hsa006500.30883609
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30572885
97Insulin resistance_Homo sapiens_hsa049310.28832375
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.26773395
99TGF-beta signaling pathway_Homo sapiens_hsa043500.26749378
100Propanoate metabolism_Homo sapiens_hsa006400.26440369
101Adherens junction_Homo sapiens_hsa045200.24157074
102Pyruvate metabolism_Homo sapiens_hsa006200.23643897
1032-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.22875825
104Pentose phosphate pathway_Homo sapiens_hsa000300.22847459
105Serotonergic synapse_Homo sapiens_hsa047260.22466733
106Fatty acid elongation_Homo sapiens_hsa000620.21414116
107TNF signaling pathway_Homo sapiens_hsa046680.20998075
108Vitamin digestion and absorption_Homo sapiens_hsa049770.20222143
109Ovarian steroidogenesis_Homo sapiens_hsa049130.19912995
110Sphingolipid metabolism_Homo sapiens_hsa006000.19642955
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18499451
112Selenocompound metabolism_Homo sapiens_hsa004500.18132078
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.17312828
114Ras signaling pathway_Homo sapiens_hsa040140.16530396
115Toll-like receptor signaling pathway_Homo sapiens_hsa046200.16004052
116Glutathione metabolism_Homo sapiens_hsa004800.15760558
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.14415002
118Biosynthesis of amino acids_Homo sapiens_hsa012300.13626634
119Retinol metabolism_Homo sapiens_hsa008300.13595595
120Mineral absorption_Homo sapiens_hsa049780.12985268
121Glucagon signaling pathway_Homo sapiens_hsa049220.12149209
122Oxidative phosphorylation_Homo sapiens_hsa001900.11954926
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.11721817
124AMPK signaling pathway_Homo sapiens_hsa041520.09529724
125Protein digestion and absorption_Homo sapiens_hsa049740.06384616
126Renin-angiotensin system_Homo sapiens_hsa046140.04610076
127Circadian rhythm_Homo sapiens_hsa047100.02567497
128Systemic lupus erythematosus_Homo sapiens_hsa053220.00722892
129Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.1022379
130Cardiac muscle contraction_Homo sapiens_hsa04260-0.1011103
131Fatty acid biosynthesis_Homo sapiens_hsa00061-0.0977145
132Cocaine addiction_Homo sapiens_hsa05030-0.0670525
133Ether lipid metabolism_Homo sapiens_hsa00565-0.0646224
134Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.0406899
135Protein export_Homo sapiens_hsa03060-0.0376510
136Hedgehog signaling pathway_Homo sapiens_hsa04340-0.0190509
137Steroid biosynthesis_Homo sapiens_hsa00100-0.0138759
138Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0118394
139Parkinsons disease_Homo sapiens_hsa05012-0.0105379
140Fructose and mannose metabolism_Homo sapiens_hsa00051-0.0018987

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