PRH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid and submandibular/sublingual glands. In western population this locus is commonly biallelic and encodes proline-rich protein (PRP) isoforms, PRP-1 and PRP-2. The reference genome encodes the PRP-1 allele. Certain alleles of this gene are associated with susceptibility to dental caries. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)5.93745488
2mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)5.02260074
3positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021105.02260074
4positive regulation of mitochondrial fission (GO:0090141)4.94086625
5protein localization to cilium (GO:0061512)4.54800064
6pyrimidine nucleobase catabolic process (GO:0006208)4.36505577
7protein polyglutamylation (GO:0018095)4.21747149
8acrosome reaction (GO:0007340)4.21594743
9retinal cone cell development (GO:0046549)4.16537765
10epithelial cilium movement (GO:0003351)3.98506193
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.96575207
12axoneme assembly (GO:0035082)3.95217647
13base-excision repair, AP site formation (GO:0006285)3.91251599
14preassembly of GPI anchor in ER membrane (GO:0016254)3.84732145
15intraciliary transport (GO:0042073)3.79393940
16nucleobase catabolic process (GO:0046113)3.76648451
17regulation of cilium movement (GO:0003352)3.63812585
18platelet dense granule organization (GO:0060155)3.61529393
19water-soluble vitamin biosynthetic process (GO:0042364)3.61224801
20GPI anchor metabolic process (GO:0006505)3.55917941
21histone H2A acetylation (GO:0043968)3.53823052
22behavioral response to nicotine (GO:0035095)3.35266036
23prenylation (GO:0097354)3.34468621
24protein prenylation (GO:0018342)3.34468621
25neural tube formation (GO:0001841)3.31483647
26regulation of mitochondrial fission (GO:0090140)3.27438783
27regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)3.24098794
28DNA double-strand break processing (GO:0000729)3.20630417
29GPI anchor biosynthetic process (GO:0006506)3.17476976
30peroxisome fission (GO:0016559)3.16991503
31C-terminal protein lipidation (GO:0006501)3.15505440
32cilium assembly (GO:0042384)3.14974810
33cilium movement (GO:0003341)3.12997727
34regulation of telomere maintenance (GO:0032204)3.12757222
35cilium organization (GO:0044782)3.12284663
36peptidyl-cysteine modification (GO:0018198)3.07552227
37cilium or flagellum-dependent cell motility (GO:0001539)3.04151543
38photoreceptor cell development (GO:0042461)3.02400239
39olfactory bulb development (GO:0021772)3.01459124
40eye photoreceptor cell development (GO:0042462)3.00413060
41RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.99856813
42tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.99856813
43branched-chain amino acid catabolic process (GO:0009083)2.98854692
44head development (GO:0060322)2.96867062
45aldehyde catabolic process (GO:0046185)2.96748117
46C-terminal protein amino acid modification (GO:0018410)2.92844693
47regulation of relaxation of muscle (GO:1901077)2.92740283
48DNA damage response, detection of DNA damage (GO:0042769)2.92536704
49binding of sperm to zona pellucida (GO:0007339)2.91521707
50regulation of mitochondrial translation (GO:0070129)2.88151919
51photoreceptor cell maintenance (GO:0045494)2.85375474
52sperm-egg recognition (GO:0035036)2.83667597
53regulation of cell communication by electrical coupling (GO:0010649)2.83576782
54righting reflex (GO:0060013)2.82869487
55single strand break repair (GO:0000012)2.81517336
56peptidyl-histidine modification (GO:0018202)2.80579147
57retinal rod cell development (GO:0046548)2.79300410
58cilium morphogenesis (GO:0060271)2.78645473
59respiratory chain complex IV assembly (GO:0008535)2.77720900
60sperm motility (GO:0030317)2.77089828
61regulation of hexokinase activity (GO:1903299)2.76550166
62regulation of glucokinase activity (GO:0033131)2.76550166
63calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.74806655
64nonmotile primary cilium assembly (GO:0035058)2.74093499
65negative regulation of telomere maintenance (GO:0032205)2.71847541
66anterograde synaptic vesicle transport (GO:0048490)2.69996197
67adenosine metabolic process (GO:0046085)2.69543761
68cholesterol biosynthetic process (GO:0006695)2.68515822
69lipid particle organization (GO:0034389)2.66358081
70negative regulation of sodium ion transport (GO:0010766)2.64817948
71positive regulation of mitochondrial membrane permeability (GO:0035794)2.64581429
72tRNA methylation (GO:0030488)2.63942583
73coenzyme catabolic process (GO:0009109)2.63314614
74ADP metabolic process (GO:0046031)2.62598126
75DNA integration (GO:0015074)2.60632867
76cellular ketone body metabolic process (GO:0046950)2.58626656
77melanosome transport (GO:0032402)2.57279069
78protein complex biogenesis (GO:0070271)2.55795736
79cullin deneddylation (GO:0010388)2.54887549
80glycolipid biosynthetic process (GO:0009247)2.54713323
81sulfur amino acid catabolic process (GO:0000098)2.52803044
82mannosylation (GO:0097502)2.51602760
83tRNA modification (GO:0006400)2.49942529
84cytochrome complex assembly (GO:0017004)2.49531178
85detection of light stimulus involved in sensory perception (GO:0050962)2.49316873
86detection of light stimulus involved in visual perception (GO:0050908)2.49316873
87positive regulation of TOR signaling (GO:0032008)2.48946574
88mitochondrial fission (GO:0000266)2.48847071
89pigment granule transport (GO:0051904)2.47171859
90L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.46258227
91establishment of melanosome localization (GO:0032401)2.45581533
92cellular component assembly involved in morphogenesis (GO:0010927)2.45038991
93rRNA catabolic process (GO:0016075)2.43654180
94sterol biosynthetic process (GO:0016126)2.42907716
95mitochondrial respiratory chain complex assembly (GO:0033108)2.41607800
96DNA damage induced protein phosphorylation (GO:0006975)2.39354550
97regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.36726870
98phosphatidylethanolamine metabolic process (GO:0046337)2.36493590
99establishment of pigment granule localization (GO:0051905)2.36422356
100retinal ganglion cell axon guidance (GO:0031290)2.36315259

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.81047897
2ZNF274_21170338_ChIP-Seq_K562_Hela3.54198335
3GBX2_23144817_ChIP-Seq_PC3_Human3.44387823
4IGF1R_20145208_ChIP-Seq_DFB_Human3.42719279
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.92648840
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.82591958
7FUS_26573619_Chip-Seq_HEK293_Human2.60455623
8EZH2_22144423_ChIP-Seq_EOC_Human2.58380190
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.58187535
10TAF15_26573619_Chip-Seq_HEK293_Human2.31626928
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.30528923
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.26484296
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.17444018
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.08247141
15VDR_22108803_ChIP-Seq_LS180_Human2.02214724
16P300_19829295_ChIP-Seq_ESCs_Human1.97616175
17CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.96154158
18AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.87561182
19PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82737354
20EWS_26573619_Chip-Seq_HEK293_Human1.79618907
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.70971348
22IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.69422835
23CBP_20019798_ChIP-Seq_JUKART_Human1.69422835
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68901369
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67389833
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62556073
27ER_23166858_ChIP-Seq_MCF-7_Human1.60208043
28TP53_22573176_ChIP-Seq_HFKS_Human1.58934858
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.58302712
30SMAD4_21799915_ChIP-Seq_A2780_Human1.57156898
31IRF1_19129219_ChIP-ChIP_H3396_Human1.56981984
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55441710
33MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54318709
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53992952
35SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52294712
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.51853482
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51628212
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51538952
39OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49359975
40KLF5_20875108_ChIP-Seq_MESCs_Mouse1.47589185
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45981858
42STAT3_23295773_ChIP-Seq_U87_Human1.44753931
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.43398016
44ELK1_19687146_ChIP-ChIP_HELA_Human1.39006073
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38745986
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35471210
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.33123479
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.32462142
49AR_25329375_ChIP-Seq_VCAP_Human1.28050395
50RUNX2_22187159_ChIP-Seq_PCA_Human1.25917980
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.25362793
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24635427
53VDR_23849224_ChIP-Seq_CD4+_Human1.24611516
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24261192
55BCAT_22108803_ChIP-Seq_LS180_Human1.23849047
56TCF4_23295773_ChIP-Seq_U87_Human1.23170599
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18570638
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.18111751
59ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16695243
60EST1_17652178_ChIP-ChIP_JURKAT_Human1.16506339
61TAL1_26923725_Chip-Seq_HPCs_Mouse1.15767998
62MYC_18940864_ChIP-ChIP_HL60_Human1.15247164
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.14901945
64NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14527030
65HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14019791
66FLI1_21867929_ChIP-Seq_TH2_Mouse1.13341015
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11378368
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11143152
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10769094
70E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10359335
71FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10031244
72JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.09188360
73TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07697417
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07508261
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.06990345
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06990345
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06916230
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06916230
79RNF2_27304074_Chip-Seq_NSC_Mouse1.06814133
80GATA3_21878914_ChIP-Seq_MCF-7_Human1.06579401
81TP53_18474530_ChIP-ChIP_U2OS_Human1.06218327
82NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05374944
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05087339
84TCF4_22108803_ChIP-Seq_LS180_Human1.04965673
85CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03977658
86SMAD4_21741376_ChIP-Seq_EPCs_Human1.02518112
87NANOG_19829295_ChIP-Seq_ESCs_Human1.02177909
88SOX2_19829295_ChIP-Seq_ESCs_Human1.02177909
89CBX2_27304074_Chip-Seq_ESCs_Mouse1.01544012
90CIITA_25753668_ChIP-Seq_RAJI_Human1.01154050
91CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00836422
92ETS1_20019798_ChIP-Seq_JURKAT_Human1.00095712
93REST_21632747_ChIP-Seq_MESCs_Mouse0.99368889
94SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99037346
95FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98577079
96JUN_21703547_ChIP-Seq_K562_Human0.98248252
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97750209
98CRX_20693478_ChIP-Seq_RETINA_Mouse0.96707564
99FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94510120
100PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94322175

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode2.97730327
2MP0003880_abnormal_central_pattern2.66781518
3MP0008789_abnormal_olfactory_epithelium2.61926306
4MP0005394_taste/olfaction_phenotype2.50841037
5MP0005499_abnormal_olfactory_system2.50841037
6MP0003122_maternal_imprinting2.48849926
7MP0005645_abnormal_hypothalamus_physiol2.43072077
8MP0002102_abnormal_ear_morphology2.38217962
9MP0000372_irregular_coat_pigmentation2.33664342
10MP0006276_abnormal_autonomic_nervous2.26597568
11MP0009046_muscle_twitch2.18226659
12MP0005551_abnormal_eye_electrophysiolog2.16390548
13MP0004133_heterotaxia2.16193555
14MP0001529_abnormal_vocalization2.14893968
15MP0005379_endocrine/exocrine_gland_phen2.05236025
16MP0002163_abnormal_gland_morphology2.05095780
17MP0003011_delayed_dark_adaptation1.93747398
18MP0005410_abnormal_fertilization1.92341174
19MP0010386_abnormal_urinary_bladder1.90191459
20MP0005253_abnormal_eye_physiology1.88180765
21MP0002909_abnormal_adrenal_gland1.86940226
22MP0006072_abnormal_retinal_apoptosis1.85307205
23MP0003121_genomic_imprinting1.83337539
24MP0001984_abnormal_olfaction1.73117229
25MP0002653_abnormal_ependyma_morphology1.71688775
26MP0002234_abnormal_pharynx_morphology1.68652192
27MP0002822_catalepsy1.68175245
28MP0004147_increased_porphyrin_level1.67275196
29MP0002254_reproductive_system_inflammat1.64955483
30MP0001764_abnormal_homeostasis1.62826758
31MP0002638_abnormal_pupillary_reflex1.53102501
32MP0002837_dystrophic_cardiac_calcinosis1.49119839
33MP0000013_abnormal_adipose_tissue1.45438581
34MP0008877_abnormal_DNA_methylation1.44773616
35MP0003787_abnormal_imprinting1.38907593
36MP0004484_altered_response_of1.34648836
37MP0000631_abnormal_neuroendocrine_gland1.34108039
38MP0005084_abnormal_gallbladder_morpholo1.33299518
39MP0000427_abnormal_hair_cycle1.31248101
40MP0003646_muscle_fatigue1.28357001
41MP0002751_abnormal_autonomic_nervous1.28307820
42MP0002272_abnormal_nervous_system1.28211488
43MP0000778_abnormal_nervous_system1.27118666
44MP0000639_abnormal_adrenal_gland1.25573175
45MP0002332_abnormal_exercise_endurance1.20936821
46MP0005646_abnormal_pituitary_gland1.19855827
47MP0002938_white_spotting1.18729822
48MP0001486_abnormal_startle_reflex1.18056040
49MP0002233_abnormal_nose_morphology1.17393611
50MP0002160_abnormal_reproductive_system1.16223649
51MP0004924_abnormal_behavior1.15659946
52MP0005386_behavior/neurological_phenoty1.15659946
53MP0005266_abnormal_metabolism1.15540088
54MP0005670_abnormal_white_adipose1.15182986
55MP0000049_abnormal_middle_ear1.14713299
56MP0002876_abnormal_thyroid_physiology1.13708194
57MP0008872_abnormal_physiological_respon1.12710419
58MP0002735_abnormal_chemical_nociception1.12071437
59MP0008058_abnormal_DNA_repair1.10004386
60MP0000383_abnormal_hair_follicle1.09133597
61MP0004142_abnormal_muscle_tone1.09021579
62MP0008995_early_reproductive_senescence1.03017004
63MP0001968_abnormal_touch/_nociception1.02308261
64MP0002736_abnormal_nociception_after1.02017420
65MP0005248_abnormal_Harderian_gland1.01778575
66MP0002557_abnormal_social/conspecific_i1.01450692
67MP0002752_abnormal_somatic_nervous1.00991826
68MP0003698_abnormal_male_reproductive0.98878695
69MP0005075_abnormal_melanosome_morpholog0.97951052
70MP0009745_abnormal_behavioral_response0.97349457
71MP0005332_abnormal_amino_acid0.97156673
72MP0005195_abnormal_posterior_eye0.94715471
73MP0002184_abnormal_innervation0.92986634
74MP0003656_abnormal_erythrocyte_physiolo0.92422740
75MP0002067_abnormal_sensory_capabilities0.92010059
76MP0002295_abnormal_pulmonary_circulatio0.91514061
77MP0000230_abnormal_systemic_arterial0.91273674
78MP0003718_maternal_effect0.86089223
79MP0000569_abnormal_digit_pigmentation0.84607091
80MP0003221_abnormal_cardiomyocyte_apopto0.84301535
81MP0004215_abnormal_myocardial_fiber0.83690055
82MP0000538_abnormal_urinary_bladder0.83246460
83MP0000026_abnormal_inner_ear0.82818977
84MP0000566_synostosis0.82535639
85MP0008875_abnormal_xenobiotic_pharmacok0.82331560
86MP0001502_abnormal_circadian_rhythm0.81882243
87MP0002572_abnormal_emotion/affect_behav0.80756971
88MP0001324_abnormal_eye_pigmentation0.80051696
89MP0001929_abnormal_gametogenesis0.79600133
90MP0004742_abnormal_vestibular_system0.79424329
91MP0001485_abnormal_pinna_reflex0.78099290
92MP0008775_abnormal_heart_ventricle0.77904795
93MP0009697_abnormal_copulation0.77551786
94MP0001270_distended_abdomen0.77504165
95MP0005391_vision/eye_phenotype0.77179971
96MP0004043_abnormal_pH_regulation0.76993090
97MP0003786_premature_aging0.76311669
98MP0002229_neurodegeneration0.75198041
99MP0002882_abnormal_neuron_morphology0.74740078
100MP0001188_hyperpigmentation0.74217036

Predicted human phenotypes

RankGene SetZ-score
1Short tibia (HP:0005736)3.78172866
2Aplasia/Hypoplasia of the tibia (HP:0005772)3.63697083
3Abnormality of glycolysis (HP:0004366)3.49118064
4Pancreatic fibrosis (HP:0100732)3.46318909
5Medial flaring of the eyebrow (HP:0010747)3.45600278
6Intestinal atresia (HP:0011100)3.38946268
7Pancreatic cysts (HP:0001737)3.28957499
8True hermaphroditism (HP:0010459)3.27465447
9Long foot (HP:0001833)3.23800965
10Gait imbalance (HP:0002141)3.18012765
11Congenital primary aphakia (HP:0007707)3.16646299
12Tubulointerstitial nephritis (HP:0001970)3.09999858
13Aplasia/Hypoplasia of the tongue (HP:0010295)3.02086552
14Chronic hepatic failure (HP:0100626)2.93114001
15Nephronophthisis (HP:0000090)2.91603713
16Increased serum pyruvate (HP:0003542)2.88797594
17Polyphagia (HP:0002591)2.85646160
18Postaxial foot polydactyly (HP:0001830)2.77467366
19Abnormality of midbrain morphology (HP:0002418)2.76614548
20Molar tooth sign on MRI (HP:0002419)2.76614548
21Nephrogenic diabetes insipidus (HP:0009806)2.73331644
22Genital tract atresia (HP:0001827)2.58708448
23Cortical dysplasia (HP:0002539)2.58663188
24Vaginal atresia (HP:0000148)2.48790689
25Broad foot (HP:0001769)2.48276254
26Upper limb muscle weakness (HP:0003484)2.46492468
27Occipital encephalocele (HP:0002085)2.38521392
28Fibular aplasia (HP:0002990)2.32575764
29Abnormality of the labia minora (HP:0012880)2.30906559
30Attenuation of retinal blood vessels (HP:0007843)2.29927687
31Double outlet right ventricle (HP:0001719)2.28581376
32Congenital malformation of the right heart (HP:0011723)2.28581376
33Bile duct proliferation (HP:0001408)2.28538685
34Abnormal biliary tract physiology (HP:0012439)2.28538685
35Cystic liver disease (HP:0006706)2.27989226
36Abnormality of the renal medulla (HP:0100957)2.27672455
37Aplasia/Hypoplasia of the fibula (HP:0006492)2.21401205
38Postaxial hand polydactyly (HP:0001162)2.19973800
39Tubulointerstitial abnormality (HP:0001969)2.19778342
40Poor coordination (HP:0002370)2.19316126
41Keratoconus (HP:0000563)2.16929464
42Increased corneal curvature (HP:0100692)2.16929464
43Hypothermia (HP:0002045)2.16449350
44Abnormal gallbladder physiology (HP:0012438)2.16046409
45Cholecystitis (HP:0001082)2.16046409
46Pendular nystagmus (HP:0012043)2.13663946
47Progressive microcephaly (HP:0000253)2.11930027
48Broad alveolar ridges (HP:0000187)2.11059810
49Dyskinesia (HP:0100660)2.09836280
50Agitation (HP:0000713)2.08318316
51Colon cancer (HP:0003003)2.06301649
52Increased hepatocellular lipid droplets (HP:0006565)2.05972822
53Abnormality of the renal collecting system (HP:0004742)2.05965220
54Lipid accumulation in hepatocytes (HP:0006561)2.05198832
55Duplicated collecting system (HP:0000081)2.04979824
56Exercise-induced muscle cramps (HP:0003710)2.03888087
57Specific learning disability (HP:0001328)2.01796945
58Sclerocornea (HP:0000647)1.98016320
59Hyperalaninemia (HP:0003348)1.96370531
60Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.96370531
61Abnormality of alanine metabolism (HP:0010916)1.96370531
62Abnormality of the metopic suture (HP:0005556)1.93469139
63Preaxial hand polydactyly (HP:0001177)1.92009164
64Drooling (HP:0002307)1.90824359
653-Methylglutaconic aciduria (HP:0003535)1.90460058
66Failure to thrive in infancy (HP:0001531)1.90040859
67Decreased muscle mass (HP:0003199)1.87760846
68Tubular atrophy (HP:0000092)1.87070345
69Anencephaly (HP:0002323)1.86038796
70Stage 5 chronic kidney disease (HP:0003774)1.86022248
71Renal Fanconi syndrome (HP:0001994)1.85296148
72Ketosis (HP:0001946)1.85230515
73Congenital hepatic fibrosis (HP:0002612)1.84333717
74Neoplasm of the heart (HP:0100544)1.83998308
75Growth hormone deficiency (HP:0000824)1.83545473
76Abnormality of the aortic arch (HP:0012303)1.82012527
77Rib fusion (HP:0000902)1.81701703
78Hepatocellular necrosis (HP:0001404)1.81591530
79Decreased testicular size (HP:0008734)1.80502545
80Severe visual impairment (HP:0001141)1.78638940
81Thyroid-stimulating hormone excess (HP:0002925)1.78464747
82Fibular hypoplasia (HP:0003038)1.78258779
83Methylmalonic acidemia (HP:0002912)1.78056402
84Astigmatism (HP:0000483)1.75720080
85Progressive cerebellar ataxia (HP:0002073)1.74067271
86Opisthotonus (HP:0002179)1.71425128
87Abnormality of the renal cortex (HP:0011035)1.70591261
88Mitochondrial inheritance (HP:0001427)1.70085745
89Congenital stationary night blindness (HP:0007642)1.69199277
90Narrow forehead (HP:0000341)1.68983565
91Genetic anticipation (HP:0003743)1.68315429
92Abnormal respiratory epithelium morphology (HP:0012253)1.66208392
93Abnormal respiratory motile cilium morphology (HP:0005938)1.66208392
94Gastrointestinal atresia (HP:0002589)1.65983804
95Ketoacidosis (HP:0001993)1.65896749
96Excessive salivation (HP:0003781)1.65571597
97Oligodactyly (HP:0012165)1.65163295
98Abnormality of the lower motor neuron (HP:0002366)1.62218889
99Oculomotor apraxia (HP:0000657)1.60670950
100Poor suck (HP:0002033)1.60450683

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK2.80374188
2TRIM282.75237918
3BCR2.10077471
4ZAK2.00262538
5* MAP4K212.7305124
6INSRR1.92251134
7MAP3K41.84804731
8WNK31.74563882
9FRK1.74440813
10CDK191.38442639
11MAPK131.34891777
12CSNK1G31.28576665
13ERBB31.25942569
14GRK11.24286195
15EIF2AK31.23677084
16EPHA41.19721122
17CSNK1G21.19440231
18CSNK1A1L1.17817640
19TNIK1.16915751
20NUAK11.15394724
21MAP2K71.06508773
22LMTK21.05635911
23DYRK31.00728218
24SRPK10.99421320
25CSNK1G10.99158815
26OXSR10.97123173
27ADRBK20.96984523
28PINK10.94609231
29PIM20.93190687
30PAK30.86233645
31OBSCN0.83689673
32FLT30.82977469
33BMPR1B0.81007104
34PLK20.78527577
35MARK10.77331091
36PRKD30.67367712
37STK38L0.63865428
38PKN20.63711042
39SIK30.63483151
40DAPK20.60857918
41RPS6KA40.60833761
42MKNK10.59025147
43WNK40.57899806
44PLK40.56539421
45GRK50.54909269
46PRKCE0.53907761
47DYRK20.52084776
48MST1R0.52021419
49LATS10.51608572
50RPS6KA50.51492303
51VRK10.49987920
52NTRK20.48738438
53MUSK0.48327777
54CASK0.48013833
55STK390.45022918
56KSR10.44845641
57CAMK2D0.42137983
58CSNK1A10.41503582
59MAP3K70.40912805
60BRD40.40323416
61DYRK1B0.40026156
62FER0.38184827
63EPHB20.37278219
64CAMKK20.36826522
65CDK30.36617275
66LIMK10.34518711
67CAMK40.34434671
68ATR0.34224094
69GRK70.32880714
70MAP3K50.32829932
71ADRBK10.32587419
72PDK20.31593886
73ATM0.31316174
74CDK50.29973880
75ARAF0.28929787
76PRKCG0.28734851
77CDK80.28330876
78STK240.28036588
79PRKAA10.27910086
80NME10.27608033
81STK160.27495909
82PLK30.27064028
83RPS6KB10.26919078
84RAF10.26771486
85MINK10.26363208
86CAMK10.25241222
87PRKACA0.24532301
88PRKG10.24251310
89TLK10.22951083
90MAP2K40.22717704
91PHKG20.22414995
92PHKG10.22414995
93NEK10.21911283
94CAMK2B0.21314593
95CAMK2A0.20282495
96TGFBR10.19757255
97TNK20.19738353
98AKT30.18977743
99MET0.18086179
100PRKACB0.17976752

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.67125947
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.81419410
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.76952842
4Propanoate metabolism_Homo sapiens_hsa006402.36896109
5Protein export_Homo sapiens_hsa030602.33265066
6Sulfur metabolism_Homo sapiens_hsa009202.25206167
7Phototransduction_Homo sapiens_hsa047442.23704633
8Steroid biosynthesis_Homo sapiens_hsa001002.12512146
9Butanoate metabolism_Homo sapiens_hsa006502.09331936
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.05512670
11Regulation of autophagy_Homo sapiens_hsa041401.91821992
12Basal transcription factors_Homo sapiens_hsa030221.86942374
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73416141
14Peroxisome_Homo sapiens_hsa041461.68492271
15Taste transduction_Homo sapiens_hsa047421.67173655
16Base excision repair_Homo sapiens_hsa034101.60841036
17Linoleic acid metabolism_Homo sapiens_hsa005911.58579652
18Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.56580189
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.43756987
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.43212020
21Nicotine addiction_Homo sapiens_hsa050331.42180154
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.41926414
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.39341499
24Circadian rhythm_Homo sapiens_hsa047101.34959198
25Selenocompound metabolism_Homo sapiens_hsa004501.34152728
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33540924
27Non-homologous end-joining_Homo sapiens_hsa034501.33046986
28Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.32134578
29RNA degradation_Homo sapiens_hsa030181.29014405
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28409134
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.27427545
32Ether lipid metabolism_Homo sapiens_hsa005651.23698160
33Olfactory transduction_Homo sapiens_hsa047401.22468763
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.21429097
35Oxidative phosphorylation_Homo sapiens_hsa001901.20053949
36GABAergic synapse_Homo sapiens_hsa047271.19306346
37Fatty acid elongation_Homo sapiens_hsa000621.16924306
38Retinol metabolism_Homo sapiens_hsa008301.16597573
39Tryptophan metabolism_Homo sapiens_hsa003801.14458335
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13789218
41Caffeine metabolism_Homo sapiens_hsa002321.11756704
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.11519490
43Nitrogen metabolism_Homo sapiens_hsa009101.09513768
44Homologous recombination_Homo sapiens_hsa034401.09437265
45Collecting duct acid secretion_Homo sapiens_hsa049661.08551187
46Arginine and proline metabolism_Homo sapiens_hsa003301.04171265
47Morphine addiction_Homo sapiens_hsa050320.98776188
48RNA polymerase_Homo sapiens_hsa030200.98464933
49Proteasome_Homo sapiens_hsa030500.96850687
50Fanconi anemia pathway_Homo sapiens_hsa034600.95478487
51Insulin secretion_Homo sapiens_hsa049110.95078589
52Vitamin B6 metabolism_Homo sapiens_hsa007500.92330472
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91275749
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89069543
55ABC transporters_Homo sapiens_hsa020100.87106930
56Purine metabolism_Homo sapiens_hsa002300.87029195
57Biosynthesis of amino acids_Homo sapiens_hsa012300.85610559
58Chemical carcinogenesis_Homo sapiens_hsa052040.82892717
59Metabolic pathways_Homo sapiens_hsa011000.81207453
60Carbon metabolism_Homo sapiens_hsa012000.80951775
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.80732920
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78933795
63* Salivary secretion_Homo sapiens_hsa049700.78736914
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78641827
65Oocyte meiosis_Homo sapiens_hsa041140.75540200
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74981035
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72864437
68Fatty acid metabolism_Homo sapiens_hsa012120.72655101
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.70988224
70Dopaminergic synapse_Homo sapiens_hsa047280.70871561
71Parkinsons disease_Homo sapiens_hsa050120.70799174
72Lysine degradation_Homo sapiens_hsa003100.70462978
73Hedgehog signaling pathway_Homo sapiens_hsa043400.67294326
74Alcoholism_Homo sapiens_hsa050340.66052439
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65771162
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64665468
77Fat digestion and absorption_Homo sapiens_hsa049750.64543434
78Glycerolipid metabolism_Homo sapiens_hsa005610.63297699
79Huntingtons disease_Homo sapiens_hsa050160.63120594
80RNA transport_Homo sapiens_hsa030130.60676171
81Synaptic vesicle cycle_Homo sapiens_hsa047210.60645395
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.59925392
83beta-Alanine metabolism_Homo sapiens_hsa004100.59052261
84Pyruvate metabolism_Homo sapiens_hsa006200.58280832
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58022604
86Vibrio cholerae infection_Homo sapiens_hsa051100.57197289
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.56428835
88TGF-beta signaling pathway_Homo sapiens_hsa043500.56161880
89Fatty acid degradation_Homo sapiens_hsa000710.52260295
90Arachidonic acid metabolism_Homo sapiens_hsa005900.52066179
91Circadian entrainment_Homo sapiens_hsa047130.51661431
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50617228
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49774577
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44376281
95Mineral absorption_Homo sapiens_hsa049780.44213487
96Glutamatergic synapse_Homo sapiens_hsa047240.43612870
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41479028
98Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39943619
99Folate biosynthesis_Homo sapiens_hsa007900.39443299
100Arginine biosynthesis_Homo sapiens_hsa002200.39263290

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »