PRICKLE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)6.44731366
2axon ensheathment in central nervous system (GO:0032291)6.44731366
3myelination (GO:0042552)5.43520914
4ensheathment of neurons (GO:0007272)5.39481883
5axon ensheathment (GO:0008366)5.39481883
6negative regulation of neurotransmitter secretion (GO:0046929)4.70365305
7presynaptic membrane assembly (GO:0097105)4.64903366
8negative regulation of peptidyl-threonine phosphorylation (GO:0010801)4.37307660
9neuron cell-cell adhesion (GO:0007158)4.35882345
10long-chain fatty acid biosynthetic process (GO:0042759)4.29956756
11presynaptic membrane organization (GO:0097090)4.27586111
12fatty acid elongation (GO:0030497)4.27218142
13negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.14223602
14transmission of nerve impulse (GO:0019226)4.10808097
15peripheral nervous system axon ensheathment (GO:0032292)4.05425511
16myelination in peripheral nervous system (GO:0022011)4.05425511
17apical protein localization (GO:0045176)4.00084812
18negative regulation of neurotransmitter transport (GO:0051589)3.96017032
19paraxial mesoderm development (GO:0048339)3.95400475
20L-amino acid import (GO:0043092)3.72383790
21positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.63774691
22asymmetric protein localization (GO:0008105)3.62495051
23* regulation of cardioblast differentiation (GO:0051890)3.61693698
24glycerophospholipid catabolic process (GO:0046475)3.60572182
25lung-associated mesenchyme development (GO:0060484)3.55753487
26neuronal action potential propagation (GO:0019227)3.55270420
27locomotory exploration behavior (GO:0035641)3.53719285
28response to redox state (GO:0051775)3.50843670
29regulation of posttranscriptional gene silencing (GO:0060147)3.47074264
30regulation of gene silencing by miRNA (GO:0060964)3.47074264
31regulation of gene silencing by RNA (GO:0060966)3.47074264
32substantia nigra development (GO:0021762)3.46719877
33cellular response to epinephrine stimulus (GO:0071872)3.46135764
34peptidyl-tyrosine autophosphorylation (GO:0038083)3.44082007
35synaptic vesicle exocytosis (GO:0016079)3.43623440
36oligodendrocyte differentiation (GO:0048709)3.41977153
37glutamate secretion (GO:0014047)3.39229151
38ventricular cardiac muscle cell development (GO:0055015)3.35523259
39regulation of cardiac muscle cell apoptotic process (GO:0010665)3.35025353
40positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.34851461
41negative regulation of axonogenesis (GO:0050771)3.32510799
42generation of neurons (GO:0048699)3.30891940
43regulation of short-term neuronal synaptic plasticity (GO:0048172)3.30700458
44notochord development (GO:0030903)3.29720099
45regulation of synaptic vesicle exocytosis (GO:2000300)3.25451775
46dendritic spine morphogenesis (GO:0060997)3.21656962
47cerebellar granule cell differentiation (GO:0021707)3.21095582
48protein localization to synapse (GO:0035418)3.20927307
49neuronal ion channel clustering (GO:0045161)3.20862111
50negative regulation of axon extension (GO:0030517)3.19744379
51negative regulation of protein localization to cell surface (GO:2000009)3.16388565
52photoreceptor cell differentiation (GO:0046530)3.13893585
53eye photoreceptor cell differentiation (GO:0001754)3.13893585
54regulation of collateral sprouting (GO:0048670)3.12741078
55metanephric mesenchyme development (GO:0072075)3.12032194
56cardiac muscle cell development (GO:0055013)3.11087291
57cerebral cortex radially oriented cell migration (GO:0021799)3.10229356
58neuron recognition (GO:0008038)3.08413730
59astrocyte development (GO:0014002)3.08281515
60axon extension involved in axon guidance (GO:0048846)3.06676099
61neuron projection extension involved in neuron projection guidance (GO:1902284)3.06676099
62regulation of dendritic spine morphogenesis (GO:0061001)3.06033590
63regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.05543357
64adult walking behavior (GO:0007628)3.05346044
65myelin maintenance (GO:0043217)3.02613558
66response to epinephrine (GO:0071871)3.01759230
67synaptic vesicle maturation (GO:0016188)3.01573365
68gamma-aminobutyric acid signaling pathway (GO:0007214)3.01524455
69synaptic transmission, glutamatergic (GO:0035249)3.01451622
70anterior/posterior axis specification, embryo (GO:0008595)3.01182783
71regulation of transforming growth factor beta2 production (GO:0032909)2.98803227
72ionotropic glutamate receptor signaling pathway (GO:0035235)2.98200020
73adhesion of symbiont to host cell (GO:0044650)2.97080806
74virion attachment to host cell (GO:0019062)2.97080806
75positive regulation of meiosis (GO:0045836)2.96328994
76amino acid import (GO:0043090)2.96307218
77cardiac myofibril assembly (GO:0055003)2.94578818
78bone trabecula formation (GO:0060346)2.93863682
79bundle of His cell to Purkinje myocyte communication (GO:0086069)2.93180019
80membrane assembly (GO:0071709)2.92278844
81negative regulation of striated muscle cell apoptotic process (GO:0010664)2.91511192
82axonal fasciculation (GO:0007413)2.91340890
83cardiac cell development (GO:0055006)2.87115632
84neuron-neuron synaptic transmission (GO:0007270)2.86447482
85glutamate receptor signaling pathway (GO:0007215)2.85734418
86regulation of heart morphogenesis (GO:2000826)2.84115294
87adult heart development (GO:0007512)2.83899339
88positive regulation of membrane potential (GO:0045838)2.82223676
89vocalization behavior (GO:0071625)2.81112328
90kidney mesenchyme development (GO:0072074)2.80716091
91nerve growth factor signaling pathway (GO:0038180)2.80263636
92dendrite development (GO:0016358)2.80120503
93establishment of mitochondrion localization (GO:0051654)2.78832514
94dendrite morphogenesis (GO:0048813)2.78794491
95positive regulation of cardiac muscle cell proliferation (GO:0060045)2.78333285
96regulation of dendritic spine development (GO:0060998)2.78303555
97regulation of secondary heart field cardioblast proliferation (GO:0003266)2.77466219
98regulation of cardioblast proliferation (GO:0003264)2.77466219
99regulation of striated muscle cell apoptotic process (GO:0010662)2.77056978
100cellular response to catecholamine stimulus (GO:0071870)2.74059123
101cellular response to monoamine stimulus (GO:0071868)2.74059123
102pre-miRNA processing (GO:0031054)2.73779539
103nuclear pore complex assembly (GO:0051292)2.73406306
104positive regulation of meiotic cell cycle (GO:0051446)2.71616197
105cellular response to hepatocyte growth factor stimulus (GO:0035729)2.71251418
106response to hepatocyte growth factor (GO:0035728)2.71251418
107regulation of synaptic vesicle transport (GO:1902803)2.71022301
108positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.70744762
109positive regulation of neurological system process (GO:0031646)2.68408377
110hippo signaling (GO:0035329)2.68353385
111negative regulation of chondrocyte differentiation (GO:0032331)2.68105133
112planar cell polarity pathway involved in neural tube closure (GO:0090179)2.66984320
113cell migration involved in heart development (GO:0060973)2.66618539
114regulation of dendrite morphogenesis (GO:0048814)2.65562880
115ephrin receptor signaling pathway (GO:0048013)2.64902977
116dendritic spine organization (GO:0097061)2.64802107
117nuclear pore organization (GO:0006999)2.64039851
118long-term synaptic potentiation (GO:0060291)2.61976822
119positive regulation of cardiac muscle tissue growth (GO:0055023)2.61940618
120G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.61899600
121cell communication involved in cardiac conduction (GO:0086065)2.60560006
122positive regulation of catenin import into nucleus (GO:0035413)2.60128100
123protein complex localization (GO:0031503)2.59780309
124regulation of cell fate specification (GO:0042659)2.59160357
125synaptic vesicle docking involved in exocytosis (GO:0016081)2.57644669
126atrial septum morphogenesis (GO:0060413)2.57628635
127regulation of glutamate receptor signaling pathway (GO:1900449)2.57574687
128layer formation in cerebral cortex (GO:0021819)2.55809633
129positive regulation of SMAD protein import into nucleus (GO:0060391)2.55239381
130L-serine metabolic process (GO:0006563)2.55089861
131regulation of excitatory postsynaptic membrane potential (GO:0060079)2.54986159
132artery development (GO:0060840)2.54605763
133regulation of long-term neuronal synaptic plasticity (GO:0048169)2.54388385
134exploration behavior (GO:0035640)2.53975373
135regulation of neuronal synaptic plasticity (GO:0048168)2.52830454
136negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.51273069
137regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.51138204
138response to catecholamine (GO:0071869)2.50429150
139response to monoamine (GO:0071867)2.50429150
140positive regulation of action potential (GO:0045760)2.50394270
141regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.49895601
142G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.49547854
143cell communication by electrical coupling (GO:0010644)2.48920825
144DNA double-strand break processing (GO:0000729)2.48902829
145regulation of voltage-gated calcium channel activity (GO:1901385)2.48806045
146Rap protein signal transduction (GO:0032486)2.46330435
147negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.45681778
148negative regulation of translation, ncRNA-mediated (GO:0040033)2.45681778
149regulation of translation, ncRNA-mediated (GO:0045974)2.45681778
150myofibril assembly (GO:0030239)2.45032776
151cyclic nucleotide catabolic process (GO:0009214)2.44624650
152single strand break repair (GO:0000012)2.44251774
153positive regulation of cardiac muscle tissue development (GO:0055025)2.44234278
154neuron remodeling (GO:0016322)2.44182510
155negative regulation of synaptic transmission (GO:0050805)2.43756711
156establishment of integrated proviral latency (GO:0075713)2.43734857
157myoblast migration (GO:0051451)2.43370602
158female gonad development (GO:0008585)2.42992789
159neurotransmitter-gated ion channel clustering (GO:0072578)2.42668273
160negative regulation of cell fate commitment (GO:0010454)2.40588894
161regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.40573890
162response to X-ray (GO:0010165)2.40550565
163regulation of cardiac muscle cell proliferation (GO:0060043)2.40287573
164mesenchyme morphogenesis (GO:0072132)2.40081466
165regulation of catenin import into nucleus (GO:0035412)2.37827722
166regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.37063594
167embryonic heart tube development (GO:0035050)2.36866665
168cell fate commitment involved in formation of primary germ layer (GO:0060795)2.35182674
169NLS-bearing protein import into nucleus (GO:0006607)2.34500013
170mesenchyme development (GO:0060485)2.34471603
171cardiac chamber formation (GO:0003207)2.34376950
172lymphangiogenesis (GO:0001946)2.30950546
173collagen fibril organization (GO:0030199)2.29271329
174outer ear morphogenesis (GO:0042473)2.27621776
175embryonic foregut morphogenesis (GO:0048617)2.26338878
176ventricular trabecula myocardium morphogenesis (GO:0003222)2.24494528
177cell migration involved in sprouting angiogenesis (GO:0002042)2.23064099
178positive regulation of heart growth (GO:0060421)2.21467385
179dorsal/ventral axis specification (GO:0009950)2.20938473
180regulation of nuclear cell cycle DNA replication (GO:0033262)2.20402607
181* regulation of cardiac muscle tissue development (GO:0055024)2.19436467
182regulation of cardiac muscle tissue growth (GO:0055021)2.18157349
183regulation of mitotic spindle checkpoint (GO:1903504)2.18106692
184regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.18106692
185negative regulation of DNA repair (GO:0045738)2.17099131
186cardiac ventricle formation (GO:0003211)2.15692217
187endocardial cushion morphogenesis (GO:0003203)2.15663868
188negative regulation of keratinocyte proliferation (GO:0010839)2.14136587
189regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.14011751
190negative regulation of DNA-dependent DNA replication (GO:2000104)2.13913815
191atrial cardiac muscle cell action potential (GO:0086014)2.12897087
192cardiac muscle hypertrophy (GO:0003300)2.11893784
193mitotic metaphase plate congression (GO:0007080)2.11724291
194mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.11620722
195regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.11366202
196cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.11279528
197mitotic sister chromatid cohesion (GO:0007064)2.11110867
198organ induction (GO:0001759)2.10998875
199ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.10545759

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.71570314
2EZH2_22144423_ChIP-Seq_EOC_Human3.55040292
3E2F7_22180533_ChIP-Seq_HELA_Human3.17807152
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.10020440
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.69019537
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.63505281
7* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.63167475
8POU5F1_16153702_ChIP-ChIP_HESCs_Human2.55723133
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.49697208
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.40684532
11* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.40684532
12TAF15_26573619_Chip-Seq_HEK293_Human2.22842829
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.19431459
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19351916
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.15225108
16SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.14967560
17* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.12427932
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09836129
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.06686317
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.01397774
21DROSHA_22980978_ChIP-Seq_HELA_Human2.01268399
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.00181311
23AR_21572438_ChIP-Seq_LNCaP_Human1.96722114
24* RNF2_27304074_Chip-Seq_ESCs_Mouse1.96466197
25* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.92160261
26KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.91200166
27* EZH2_27294783_Chip-Seq_ESCs_Mouse1.90812451
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87158925
29* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.84731292
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83695864
31* RARB_27405468_Chip-Seq_BRAIN_Mouse1.81714840
32OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.79063072
33NANOG_16153702_ChIP-ChIP_HESCs_Human1.76650084
34KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.75526074
35KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.75526074
36KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.75526074
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.72658905
38* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70650524
39EWS_26573619_Chip-Seq_HEK293_Human1.66682949
40SOX2_16153702_ChIP-ChIP_HESCs_Human1.66225314
41* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65796130
42REST_21632747_ChIP-Seq_MESCs_Mouse1.65391996
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64674069
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63591690
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61747925
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61158140
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59585577
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.59574938
49FUS_26573619_Chip-Seq_HEK293_Human1.59475906
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59405581
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59108146
52HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.56964485
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55163842
54NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.53309795
55POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.53273875
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.49729037
57EP300_21415370_ChIP-Seq_HL-1_Mouse1.49466180
58SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.49105354
59* SMAD4_21799915_ChIP-Seq_A2780_Human1.48839484
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47145823
61* ISL1_27105846_Chip-Seq_CPCs_Mouse1.45193979
62* PIAS1_25552417_ChIP-Seq_VCAP_Human1.44609048
63TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.41918123
64ER_23166858_ChIP-Seq_MCF-7_Human1.41221343
65STAT3_23295773_ChIP-Seq_U87_Human1.41084150
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40664598
67* P300_19829295_ChIP-Seq_ESCs_Human1.40395044
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40183437
69E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.40001323
70REST_18959480_ChIP-ChIP_MESCs_Mouse1.39768319
71TBX3_20139965_ChIP-Seq_ESCs_Mouse1.37832676
72TBX3_20139965_ChIP-Seq_MESCs_Mouse1.37401955
73* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36857325
74TP53_18474530_ChIP-ChIP_U2OS_Human1.35337582
75AR_21909140_ChIP-Seq_LNCAP_Human1.35115891
76SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.35025921
77* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.34102752
78RNF2_27304074_Chip-Seq_NSC_Mouse1.32367338
79SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.31907276
80E2F4_17652178_ChIP-ChIP_JURKAT_Human1.30390108
81* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29862887
82TRIM28_21343339_ChIP-Seq_HEK293_Human1.28074681
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27574893
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26479608
85VDR_22108803_ChIP-Seq_LS180_Human1.26419302
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25756576
87* TCF4_23295773_ChIP-Seq_U87_Human1.25314763
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25178795
89TCF3_18692474_ChIP-Seq_MESCs_Mouse1.22902817
90FOXM1_23109430_ChIP-Seq_U2OS_Human1.22865083
91P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22821325
92GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22810258
93* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22723122
94WT1_19549856_ChIP-ChIP_CCG9911_Human1.22348617
95SOX2_21211035_ChIP-Seq_LN229_Gbm1.21394677
96ZNF274_21170338_ChIP-Seq_K562_Hela1.19811229
97STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19345736
98SMAD_19615063_ChIP-ChIP_OVARY_Human1.18597979
99* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18474131
100NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18368788
101FLI1_27457419_Chip-Seq_LIVER_Mouse1.16665622
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16605797
103IGF1R_20145208_ChIP-Seq_DFB_Human1.15284421
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15272998
105TP63_19390658_ChIP-ChIP_HaCaT_Human1.14736134
106MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14179653
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13822077
108* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13334126
109SMAD3_21741376_ChIP-Seq_HESCs_Human1.13136973
110ARNT_22903824_ChIP-Seq_MCF-7_Human1.12573362
111AHR_22903824_ChIP-Seq_MCF-7_Human1.11586673
112BRD4_25478319_ChIP-Seq_HGPS_Human1.11532832
113POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.11239491
114* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11175338
115TCF3_18692474_ChIP-Seq_MEFs_Mouse1.10600345
116WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09203992
117RING1B_27294783_Chip-Seq_NPCs_Mouse1.08663021
118RING1B_27294783_Chip-Seq_ESCs_Mouse1.07826593
119TP53_16413492_ChIP-PET_HCT116_Human1.06621622
120SOX9_26525672_Chip-Seq_HEART_Mouse1.05352047
121* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05339272
122SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.04623545
123AR_25329375_ChIP-Seq_VCAP_Human1.04283783
124PRDM14_20953172_ChIP-Seq_ESCs_Human1.04255597
125AR_19668381_ChIP-Seq_PC3_Human1.04171564
126TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.04083117
127NANOG_18555785_Chip-Seq_ESCs_Mouse1.03301330
128* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02661288
129TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02567907
130* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02007087
131* RUNX2_22187159_ChIP-Seq_PCA_Human1.01737015
132KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00656897
133SMAD3_21741376_ChIP-Seq_ESCs_Human1.00062191
134NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99167761
135GATA1_26923725_Chip-Seq_HPCs_Mouse0.97769888
136ESR1_20079471_ChIP-ChIP_T-47D_Human0.96875217
137CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.96415637
138CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96123720
139TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95878182
140UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94697367
141* LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93923802
142* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93195804
143* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93195804

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.86011074
2MP0004859_abnormal_synaptic_plasticity4.49190231
3MP0003941_abnormal_skin_development4.01374225
4MP0004270_analgesia3.85785347
5MP0000920_abnormal_myelination3.19757389
6MP0003635_abnormal_synaptic_transmissio2.87262946
7MP0005503_abnormal_tendon_morphology2.76609183
8MP0008438_abnormal_cutaneous_collagen2.73877594
9MP0002064_seizures2.54240054
10MP0001486_abnormal_startle_reflex2.52451957
11MP0010030_abnormal_orbit_morphology2.46104959
12MP0002272_abnormal_nervous_system2.42998167
13MP0009745_abnormal_behavioral_response2.41903924
14MP0004885_abnormal_endolymph2.33766521
15MP0005171_absent_coat_pigmentation2.33350595
16MP0005275_abnormal_skin_tensile2.30280391
17MP0000778_abnormal_nervous_system2.25880209
18MP0001529_abnormal_vocalization2.21923654
19MP0009046_muscle_twitch2.18622273
20MP0002063_abnormal_learning/memory/cond2.14764824
21MP0003950_abnormal_plasma_membrane2.13257279
22MP0002734_abnormal_mechanical_nocicepti2.11714746
23MP0001905_abnormal_dopamine_level2.02902728
24MP0003690_abnormal_glial_cell1.96434117
25MP0003329_amyloid_beta_deposits1.95381909
26MP0002572_abnormal_emotion/affect_behav1.92080683
27MP0001485_abnormal_pinna_reflex1.88984958
28MP0003567_abnormal_fetal_cardiomyocyte1.74020812
29MP0003119_abnormal_digestive_system1.72038348
30MP0010368_abnormal_lymphatic_system1.70255828
31MP0002254_reproductive_system_inflammat1.68330900
32MP0000049_abnormal_middle_ear1.65259915
33MP0004742_abnormal_vestibular_system1.63388854
34MP0001440_abnormal_grooming_behavior1.61809117
35MP0009250_abnormal_appendicular_skeleto1.60306220
36MP0000955_abnormal_spinal_cord1.59113226
37MP0001968_abnormal_touch/_nociception1.57003214
38MP0003634_abnormal_glial_cell1.55511065
39MP0003283_abnormal_digestive_organ1.54252244
40MP0005386_behavior/neurological_phenoty1.52569680
41MP0004924_abnormal_behavior1.52569680
42MP0003890_abnormal_embryonic-extraembry1.52566557
43MP0003705_abnormal_hypodermis_morpholog1.51622319
44MP0005423_abnormal_somatic_nervous1.51530750
45MP0002882_abnormal_neuron_morphology1.50565323
46MP0003787_abnormal_imprinting1.50237782
47MP0000462_abnormal_digestive_system1.47576519
48MP0003632_abnormal_nervous_system1.46325080
49MP0005623_abnormal_meninges_morphology1.46225001
50MP0000579_abnormal_nail_morphology1.45685221
51MP0004145_abnormal_muscle_electrophysio1.44782818
52MP0010352_gastrointestinal_tract_polyps1.41899967
53MP0009780_abnormal_chondrocyte_physiolo1.41381410
54MP0002067_abnormal_sensory_capabilities1.39777257
55MP0003755_abnormal_palate_morphology1.39555949
56MP0002233_abnormal_nose_morphology1.38222305
57MP0008057_abnormal_DNA_replication1.36443399
58MP0002229_neurodegeneration1.35470974
59MP0003942_abnormal_urinary_system1.33737908
60MP0005551_abnormal_eye_electrophysiolog1.33655904
61MP0005409_darkened_coat_color1.32694436
62MP0003935_abnormal_craniofacial_develop1.31919704
63MP0003136_yellow_coat_color1.31763567
64MP0003566_abnormal_cell_adhesion1.29468646
65MP0001293_anophthalmia1.29348220
66MP0002066_abnormal_motor_capabilities/c1.29296176
67MP0001188_hyperpigmentation1.28895236
68MP0004142_abnormal_muscle_tone1.28040261
69MP0003122_maternal_imprinting1.27154052
70MP0002751_abnormal_autonomic_nervous1.27092402
71MP0008569_lethality_at_weaning1.26589758
72MP0003937_abnormal_limbs/digits/tail_de1.26285737
73MP0005451_abnormal_body_composition1.26166085
74MP0009672_abnormal_birth_weight1.26083516
75MP0001970_abnormal_pain_threshold1.25684588
76MP0002108_abnormal_muscle_morphology1.24648295
77MP0002733_abnormal_thermal_nociception1.24420175
78MP0000749_muscle_degeneration1.23167244
79MP0001299_abnormal_eye_distance/1.22231455
80MP0004957_abnormal_blastocyst_morpholog1.21316425
81MP0008932_abnormal_embryonic_tissue1.21122092
82MP0002697_abnormal_eye_size1.20758152
83MP0008877_abnormal_DNA_methylation1.20057258
84MP0000428_abnormal_craniofacial_morphol1.19878126
85* MP0002085_abnormal_embryonic_tissue1.19154297
86MP0005646_abnormal_pituitary_gland1.18103320
87MP0002184_abnormal_innervation1.17201193
88MP0002736_abnormal_nociception_after1.16348005
89MP0003693_abnormal_embryo_hatching1.15853211
90MP0002752_abnormal_somatic_nervous1.14793045
91MP0002152_abnormal_brain_morphology1.12877890
92MP0008058_abnormal_DNA_repair1.12846834
93MP0003279_aneurysm1.11621155
94* MP0002084_abnormal_developmental_patter1.10273041
95MP0005508_abnormal_skeleton_morphology1.09712104
96MP0001286_abnormal_eye_development1.08943218
97MP0006054_spinal_hemorrhage1.06707491
98MP0001963_abnormal_hearing_physiology1.05936834
99MP0001501_abnormal_sleep_pattern1.05586553
100MP0003938_abnormal_ear_development1.04172561
101MP0003115_abnormal_respiratory_system1.03881701
102MP0003631_nervous_system_phenotype1.03490839
103MP0002102_abnormal_ear_morphology1.02836332
104MP0004133_heterotaxia1.02734263
105MP0004036_abnormal_muscle_relaxation1.02609781
106MP0010630_abnormal_cardiac_muscle1.02104635
107MP0005620_abnormal_muscle_contractility1.00749906
108MP0003111_abnormal_nucleus_morphology1.00414105
109MP0000751_myopathy1.00133991
110MP0002972_abnormal_cardiac_muscle0.99802333
111MP0002735_abnormal_chemical_nociception0.99565950
112MP0004085_abnormal_heartbeat0.98957882
113MP0002557_abnormal_social/conspecific_i0.96960784
114MP0001177_atelectasis0.96960727
115MP0005380_embryogenesis_phenotype0.96644004
116MP0001672_abnormal_embryogenesis/_devel0.96644004
117* MP0003077_abnormal_cell_cycle0.96526218
118MP0000432_abnormal_head_morphology0.95603780
119MP0004811_abnormal_neuron_physiology0.95544837
120MP0001879_abnormal_lymphatic_vessel0.94915240
121MP0002127_abnormal_cardiovascular_syste0.94844770
122MP0000566_synostosis0.93378082
123MP0002282_abnormal_trachea_morphology0.92431760
124MP0009703_decreased_birth_body0.91529970
125MP0001502_abnormal_circadian_rhythm0.91066090
126MP0003984_embryonic_growth_retardation0.90179784
127MP0008775_abnormal_heart_ventricle0.89036311
128MP0000631_abnormal_neuroendocrine_gland0.88553422
129MP0000767_abnormal_smooth_muscle0.88419110
130MP0003385_abnormal_body_wall0.88037355
131MP0009697_abnormal_copulation0.88026514
132MP0002088_abnormal_embryonic_growth/wei0.87863768
133MP0002932_abnormal_joint_morphology0.87684025
134MP0003137_abnormal_impulse_conducting0.87641334
135MP0008007_abnormal_cellular_replicative0.87512334
136MP0010678_abnormal_skin_adnexa0.86834958
137MP0004272_abnormal_basement_membrane0.86734307
138MP0002111_abnormal_tail_morphology0.86731051
139MP0003861_abnormal_nervous_system0.86564939
140MP0009053_abnormal_anal_canal0.85690929
141MP0004134_abnormal_chest_morphology0.85311543
142MP0010094_abnormal_chromosome_stability0.85129361
143MP0002116_abnormal_craniofacial_bone0.85076053
144MP0004185_abnormal_adipocyte_glucose0.85002999
145MP0002925_abnormal_cardiovascular_devel0.83992841
146MP0000383_abnormal_hair_follicle0.83787868
147MP0002114_abnormal_axial_skeleton0.83342066
148MP0001849_ear_inflammation0.82948512
149MP0003718_maternal_effect0.82798811
150MP0004087_abnormal_muscle_fiber0.82755016
151MP0005187_abnormal_penis_morphology0.81039254
152MP0005195_abnormal_posterior_eye0.80389229
153* MP0001730_embryonic_growth_arrest0.79852775
154MP0006072_abnormal_retinal_apoptosis0.79685979
155MP0002109_abnormal_limb_morphology0.79034657
156MP0000266_abnormal_heart_morphology0.76777518
157MP0005330_cardiomyopathy0.76688562
158MP0003121_genomic_imprinting0.76415544
159MP0000747_muscle_weakness0.75801362
160MP0000537_abnormal_urethra_morphology0.75659988
161MP0002837_dystrophic_cardiac_calcinosis0.75273976
162MP0003633_abnormal_nervous_system0.74598362
163MP0000026_abnormal_inner_ear0.74535440
164MP0005253_abnormal_eye_physiology0.73652249
165MP0005408_hypopigmentation0.73179445
166MP0004084_abnormal_cardiac_muscle0.72819592
167MP0002653_abnormal_ependyma_morphology0.71858764
168MP0004147_increased_porphyrin_level0.71595727
169MP0005410_abnormal_fertilization0.70548007
170MP0006138_congestive_heart_failure0.70507421
171MP0000534_abnormal_ureter_morphology0.70305190
172MP0002295_abnormal_pulmonary_circulatio0.68883943
173MP0001346_abnormal_lacrimal_gland0.67719254
174MP0000762_abnormal_tongue_morphology0.67618499
175MP0004215_abnormal_myocardial_fiber0.67338266

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.51446945
2Degeneration of the lateral corticospinal tracts (HP:0002314)5.51446945
3Focal motor seizures (HP:0011153)4.51969159
4Abnormality of the corticospinal tract (HP:0002492)4.41898777
5Neurofibrillary tangles (HP:0002185)4.36546819
6Myokymia (HP:0002411)3.95078630
7Spastic gait (HP:0002064)3.45658156
8Cerebral inclusion bodies (HP:0100314)3.45113348
9Premature rupture of membranes (HP:0001788)3.37532414
10Cerebral hypomyelination (HP:0006808)3.24678456
11Epileptic encephalopathy (HP:0200134)3.22036969
12Akinesia (HP:0002304)3.19762636
13Intention tremor (HP:0002080)3.08739738
14* Dysmetria (HP:0001310)3.07248762
15Peripheral hypomyelination (HP:0007182)3.04594764
16Termporal pattern (HP:0011008)3.01346208
17Insidious onset (HP:0003587)3.01346208
18Supranuclear gaze palsy (HP:0000605)3.00423728
19Focal seizures (HP:0007359)2.94766675
20Parakeratosis (HP:0001036)2.81595994
21Aortic dissection (HP:0002647)2.76518513
22Shallow orbits (HP:0000586)2.72322584
23Arterial tortuosity (HP:0005116)2.69796788
24Scanning speech (HP:0002168)2.69459716
25Broad-based gait (HP:0002136)2.66093025
26Thickened helices (HP:0000391)2.65273931
27Vascular tortuosity (HP:0004948)2.60977104
28Alacrima (HP:0000522)2.59844320
29Hyperventilation (HP:0002883)2.59595935
30Gaze-evoked nystagmus (HP:0000640)2.58329530
31Abnormal auditory evoked potentials (HP:0006958)2.56645986
32Cutaneous finger syndactyly (HP:0010554)2.52553364
33Ankle clonus (HP:0011448)2.52361912
34Onion bulb formation (HP:0003383)2.48146947
35Right ventricular cardiomyopathy (HP:0011663)2.44719941
36Soft skin (HP:0000977)2.41435172
37Hypoplastic pelvis (HP:0008839)2.40877065
38Atrophic scars (HP:0001075)2.36102565
39Bilateral microphthalmos (HP:0007633)2.34172290
40Cutaneous syndactyly (HP:0012725)2.33308268
41Absent speech (HP:0001344)2.28800574
42Atrial fibrillation (HP:0005110)2.27910894
43Vitreoretinal degeneration (HP:0000655)2.27788341
44Bowel diverticulosis (HP:0005222)2.27376548
45Pheochromocytoma (HP:0002666)2.27229840
46Mitral valve prolapse (HP:0001634)2.26991199
47* Sensory axonal neuropathy (HP:0003390)2.26281025
48Protrusio acetabuli (HP:0003179)2.24644611
49Choanal stenosis (HP:0000452)2.24087260
50Aplasia involving bones of the extremities (HP:0009825)2.22248303
51Aplasia involving bones of the upper limbs (HP:0009823)2.22248303
52Aplasia of the phalanges of the hand (HP:0009802)2.22248303
53Adrenal hypoplasia (HP:0000835)2.21537782
54Urinary bladder sphincter dysfunction (HP:0002839)2.20724961
55Broad metatarsal (HP:0001783)2.20392822
56Premature skin wrinkling (HP:0100678)2.20294901
57Colon cancer (HP:0003003)2.20178729
58Fetal akinesia sequence (HP:0001989)2.20035079
59Dialeptic seizures (HP:0011146)2.19448274
60Megalencephaly (HP:0001355)2.19401235
61Decreased lacrimation (HP:0000633)2.18044852
62Dysdiadochokinesis (HP:0002075)2.17801405
63Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.17347884
64Lower limb muscle weakness (HP:0007340)2.17178082
65Chin dimple (HP:0010751)2.15460804
66Turricephaly (HP:0000262)2.14405715
67Clumsiness (HP:0002312)2.13988440
68Abnormal lung lobation (HP:0002101)2.12516889
69Progressive cerebellar ataxia (HP:0002073)2.12123752
70Absence seizures (HP:0002121)2.11773721
71Aortic aneurysm (HP:0004942)2.11444411
72Pterygium (HP:0001059)2.11114188
73Widely spaced teeth (HP:0000687)2.07636372
74Ependymoma (HP:0002888)2.06838503
75Action tremor (HP:0002345)2.06504991
76Relative macrocephaly (HP:0004482)2.05212044
77Bifid tongue (HP:0010297)2.04182921
78Slow saccadic eye movements (HP:0000514)2.03852634
79Abnormality of dentin (HP:0010299)2.03832446
80Anteriorly placed anus (HP:0001545)2.03228286
81Overgrowth (HP:0001548)2.02123908
82Neonatal short-limb short stature (HP:0008921)2.01958433
83Blue irides (HP:0000635)2.01889714
84Retinal dysplasia (HP:0007973)2.00959653
85Cerebral hemorrhage (HP:0001342)2.00908264
86Abnormal hair whorl (HP:0010721)2.00434588
87Drooling (HP:0002307)1.98297544
88Excessive salivation (HP:0003781)1.98297544
89Aplasia/Hypoplasia of the sternum (HP:0006714)1.97850362
90Coronal craniosynostosis (HP:0004440)1.97003152
91Spastic diplegia (HP:0001264)1.96377471
92Primary atrial arrhythmia (HP:0001692)1.95973379
93Midline defect of the nose (HP:0004122)1.95740314
94Preaxial foot polydactyly (HP:0001841)1.94384478
95Stenosis of the external auditory canal (HP:0000402)1.93908376
96Neuroendocrine neoplasm (HP:0100634)1.93889152
97Generalized tonic-clonic seizures (HP:0002069)1.90283290
98Skull defect (HP:0001362)1.90134300
99Ectopia lentis (HP:0001083)1.89973840
100Increased serum pyruvate (HP:0003542)1.89904409
101Abnormality of glycolysis (HP:0004366)1.89904409
102Vaginal atresia (HP:0000148)1.88083329
103Supraventricular arrhythmia (HP:0005115)1.88067042
104Ventricular tachycardia (HP:0004756)1.87944697
105Absent septum pellucidum (HP:0001331)1.87276077
106CNS hypomyelination (HP:0003429)1.85598426
107Supraventricular tachycardia (HP:0004755)1.85175640
108Visual hallucinations (HP:0002367)1.85061996
109Absent eyebrow (HP:0002223)1.84425143
110Poor speech (HP:0002465)1.83928495
111Embryonal renal neoplasm (HP:0011794)1.82478309
112Cupped ear (HP:0000378)1.81274081
113Genital tract atresia (HP:0001827)1.81246657
114Abnormality of the pulmonary veins (HP:0011718)1.80816552
115Calcaneovalgus deformity (HP:0001848)1.79713555
116Anomalous pulmonary venous return (HP:0010772)1.79582900
117Nephroblastoma (Wilms tumor) (HP:0002667)1.79184763
118Increased circulating renin level (HP:0000848)1.78761362
119Aqueductal stenosis (HP:0002410)1.77545497
120Birth length less than 3rd percentile (HP:0003561)1.77238649
121Short hallux (HP:0010109)1.76476917
122Septo-optic dysplasia (HP:0100842)1.76376877
123Bladder diverticulum (HP:0000015)1.75291178
124Partial duplication of the phalanx of hand (HP:0009999)1.75110300
125Ectopic kidney (HP:0000086)1.74898587
126Aplasia/Hypoplasia of the hallux (HP:0008362)1.72763022
127Hypoplastic left heart (HP:0004383)1.72517543
128* Atonic seizures (HP:0010819)1.72006950
129Myelomeningocele (HP:0002475)1.71622596
130Hypoplasia of the iris (HP:0007676)1.71098096
131Amblyopia (HP:0000646)1.70729347
132Ankle contracture (HP:0006466)1.70426484
133Epileptiform EEG discharges (HP:0011182)1.70043594
134Abnormality of the phalanges of the 2nd finger (HP:0009541)1.69271066
135Morphological abnormality of the middle ear (HP:0008609)1.68732217
136Hepatoblastoma (HP:0002884)1.68217774
137Febrile seizures (HP:0002373)1.68000131
138Patent foramen ovale (HP:0001655)1.67809227
139Hypoplastic heart (HP:0001961)1.67445223
140Limited hip movement (HP:0008800)1.67099598
141Spastic paraparesis (HP:0002313)1.66787976
142Hip contracture (HP:0003273)1.66518968
143Impaired vibration sensation in the lower limbs (HP:0002166)1.65170413
144Sudden death (HP:0001699)1.64908562
145Maternal diabetes (HP:0009800)1.64820432
146Deformed tarsal bones (HP:0008119)1.64558150
147Bowel incontinence (HP:0002607)1.64533857
148Clonus (HP:0002169)1.63539515
149Genu recurvatum (HP:0002816)1.62702935
150Humeroradial synostosis (HP:0003041)1.62368336
151Synostosis involving the elbow (HP:0003938)1.62368336
152Absent eyelashes (HP:0000561)1.62326229
153Lipoatrophy (HP:0100578)1.61082520
154Progressive inability to walk (HP:0002505)1.60824457
155Popliteal pterygium (HP:0009756)1.60598657
156Facial cleft (HP:0002006)1.60366344
157Leukodystrophy (HP:0002415)1.59811899
158Muscle fiber splitting (HP:0003555)1.59733933
159Abnormality of the labia minora (HP:0012880)1.59565916
160Abnormality of the ischium (HP:0003174)1.59477001
161Neoplasm of the adrenal cortex (HP:0100641)1.59074820
162Urinary urgency (HP:0000012)1.58970092
163Selective tooth agenesis (HP:0001592)1.58601494
164Esophageal atresia (HP:0002032)1.57922346
165Fragile skin (HP:0001030)1.57868784
166EEG with generalized epileptiform discharges (HP:0011198)1.57558597
167Infantile muscular hypotonia (HP:0008947)1.57223190
168Abnormality of the septum pellucidum (HP:0007375)1.56986594
169Autoamputation (HP:0001218)1.56920105
170Genetic anticipation (HP:0003743)1.56878810
171Cortical dysplasia (HP:0002539)1.56384852
172Broad long bones (HP:0005622)1.56181502
173Abnormality of the astrocytes (HP:0100707)1.55793821
174Astrocytoma (HP:0009592)1.55793821
175Diminished movement (HP:0002374)1.55348603
176Hypoplastic ischia (HP:0003175)1.55288176
177Narrow nasal bridge (HP:0000446)1.55219762
178Partial agenesis of the corpus callosum (HP:0001338)1.55054470
179Hypoventilation (HP:0002791)1.54419468
180Generalized hypotonia (HP:0001290)1.52777237
181Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.52607007
182Thin ribs (HP:0000883)1.51729140
183Omphalocele (HP:0001539)1.49839703
184Short middle phalanx of the 5th finger (HP:0004220)1.48866259
185Neoplasm of the oral cavity (HP:0100649)1.48344148
186Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.47224941
187Glioma (HP:0009733)1.46624726
188Fused cervical vertebrae (HP:0002949)1.45920413
189Hypoplastic female external genitalia (HP:0012815)1.45549858
190Labial hypoplasia (HP:0000066)1.45348232
191Spinal rigidity (HP:0003306)1.45333245
192Bicornuate uterus (HP:0000813)1.44917338
193Biliary tract neoplasm (HP:0100574)1.44660204
194Bronchomalacia (HP:0002780)1.44204425
195Optic nerve hypoplasia (HP:0000609)1.43926466

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.28231718
2PRPF4B4.18505018
3EPHA43.82547553
4OXSR13.77277016
5TNIK2.97485001
6MKNK22.85378873
7CDK192.77047981
8PLK42.69044856
9BUB12.53447087
10BCR2.31847029
11PAK62.29884282
12MKNK12.17496018
13TAF12.14979407
14TSSK62.03698902
15PLK32.03559111
16TTK2.02029972
17TYRO31.96934672
18CASK1.92100312
19LATS21.84099947
20ICK1.83758257
21MYLK1.83262516
22LATS11.82579889
23NTRK31.80883188
24MET1.69647416
25WNK41.69056642
26BRSK21.65806142
27NEK61.64708302
28MAP3K41.62872319
29MARK11.55497701
30PKN11.54275217
31ZAK1.54173261
32CDC71.53437151
33EPHB11.51399740
34MAP3K91.48419638
35TRIM281.46290308
36PNCK1.43290812
37CAMK1G1.41836556
38FGFR21.40687163
39UHMK11.39587827
40NTRK11.37367173
41KSR21.36063208
42CSNK1G21.34336665
43FLT31.32961757
44CSNK1G31.32928463
45WNK31.30660565
46CSNK1A1L1.29328230
47WNK11.29182048
48NEK11.26892755
49PRKD31.25537361
50MAPK131.22527475
51PLK21.21667645
52CAMK2B1.18901220
53PTK21.18421495
54ROCK21.17282085
55STK31.17168076
56MAP2K71.16939616
57PAK31.12555860
58MAP3K101.12430551
59FGR1.11477021
60PDGFRA1.10866590
61DMPK1.10086227
62CSNK1G11.07808872
63CDK51.07500356
64PLK11.05429358
65EIF2AK31.04178823
66MST41.02542881
67MINK11.02410807
68PAK21.01974163
69MARK21.01442817
70SRPK11.00855744
71BMPR1B0.99547940
72CAMK2D0.99395060
73CAMK2A0.98904677
74SGK4940.95827217
75SGK2230.95827217
76ERBB40.92938097
77FGFR10.92303132
78DAPK20.91966965
79LIMK10.90999122
80PTK2B0.90847932
81CDK140.90378397
82TGFBR10.89527988
83FES0.87927758
84INSRR0.86147956
85PINK10.85928068
86BRSK10.85343146
87KSR10.83710515
88ARAF0.82010900
89VRK20.81993974
90CDK150.81671807
91CAMK1D0.80412350
92CDK180.79802994
93NTRK20.75182412
94NLK0.74689504
95WEE10.74424134
96CLK10.71124277
97CDK11A0.70317049
98BRD40.68663130
99PDGFRB0.67922346
100PAK40.65985387
101CAMK10.65146105
102DYRK20.65130669
103STK110.65032003
104CHEK20.64897018
105MAP3K60.63260499
106MAP2K40.63164445
107BMPR20.62421208
108CAMK2G0.62205213
109GRK10.62152468
110ALK0.60967841
111TIE10.60728973
112PRKCH0.60175719
113MAP3K130.59133111
114CDK120.58598512
115PDPK10.58575807
116PRKCE0.57918832
117ATM0.57832223
118AKT30.57688160
119STK380.57411194
120NEK20.56722838
121PHKG10.56497479
122PHKG20.56497479
123STK160.56299963
124RAF10.56046604
125MELK0.55445270
126ROCK10.54501762
127EIF2AK10.53144738
128MAP3K20.52660812
129FER0.52425372
130VRK10.51458421
131NUAK10.50432285
132MUSK0.49247620
133ERBB30.48432573
134CHEK10.47674821
135EIF2AK20.47132932
136MAPKAPK50.46389398
137DYRK1A0.46360913
138DAPK30.46249997
139CSNK1D0.45437642
140AURKB0.45339790
141GRK50.44454109
142STK38L0.44413655
143FYN0.42528217
144PRKCQ0.42383484
145CDK30.42360155
146PRKCG0.41858395
147PRKDC0.41820986
148SGK10.41334155
149RET0.40608690
150IRAK20.39609176
151PRKD10.38473058
152MAPK100.38198553
153PBK0.37668011
154STK240.37626804
155DDR20.36946374
156OBSCN0.36723577
157EPHB20.36477726
158BRAF0.34853594

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.70047929
2Axon guidance_Homo sapiens_hsa043602.45211774
3Nicotine addiction_Homo sapiens_hsa050332.41136577
4Glutamatergic synapse_Homo sapiens_hsa047242.33954992
5Synaptic vesicle cycle_Homo sapiens_hsa047212.22439931
6Non-homologous end-joining_Homo sapiens_hsa034502.18695221
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.15835965
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.10955771
9Steroid biosynthesis_Homo sapiens_hsa001002.05579643
10Adherens junction_Homo sapiens_hsa045202.04900182
11GABAergic synapse_Homo sapiens_hsa047272.04083565
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.03260004
13Circadian entrainment_Homo sapiens_hsa047132.02178782
14Ether lipid metabolism_Homo sapiens_hsa005652.00914240
15Morphine addiction_Homo sapiens_hsa050321.92464463
16Long-term potentiation_Homo sapiens_hsa047201.88934834
17Selenocompound metabolism_Homo sapiens_hsa004501.80576766
18Serotonergic synapse_Homo sapiens_hsa047261.74838114
19Long-term depression_Homo sapiens_hsa047301.72378501
20Amphetamine addiction_Homo sapiens_hsa050311.71456482
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.67284465
22Fatty acid elongation_Homo sapiens_hsa000621.66754805
23Dopaminergic synapse_Homo sapiens_hsa047281.66718356
24RNA transport_Homo sapiens_hsa030131.65033961
25Salivary secretion_Homo sapiens_hsa049701.61138009
26Cholinergic synapse_Homo sapiens_hsa047251.58144306
27Mismatch repair_Homo sapiens_hsa034301.57878682
28Cell cycle_Homo sapiens_hsa041101.53559047
29Renal cell carcinoma_Homo sapiens_hsa052111.47680246
30One carbon pool by folate_Homo sapiens_hsa006701.46786569
31Olfactory transduction_Homo sapiens_hsa047401.46212180
32Collecting duct acid secretion_Homo sapiens_hsa049661.42218781
33Proteasome_Homo sapiens_hsa030501.40427971
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.38673760
35Oxytocin signaling pathway_Homo sapiens_hsa049211.33288791
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.32555465
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.31991040
38Vascular smooth muscle contraction_Homo sapiens_hsa042701.31833959
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.30787955
40Gastric acid secretion_Homo sapiens_hsa049711.27821419
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.27441071
42Insulin secretion_Homo sapiens_hsa049111.26595526
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.26530880
44Tight junction_Homo sapiens_hsa045301.26179655
45ErbB signaling pathway_Homo sapiens_hsa040121.25944968
46Renin secretion_Homo sapiens_hsa049241.24319723
47Cocaine addiction_Homo sapiens_hsa050301.23859812
48Vibrio cholerae infection_Homo sapiens_hsa051101.20972952
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18991943
50Phospholipase D signaling pathway_Homo sapiens_hsa040721.18832389
51Protein digestion and absorption_Homo sapiens_hsa049741.18511364
52mRNA surveillance pathway_Homo sapiens_hsa030151.18358682
53Propanoate metabolism_Homo sapiens_hsa006401.18120026
54Thyroid cancer_Homo sapiens_hsa052161.17599943
55DNA replication_Homo sapiens_hsa030301.17478936
56cAMP signaling pathway_Homo sapiens_hsa040241.17022583
57Aldosterone synthesis and secretion_Homo sapiens_hsa049251.15593968
58Cardiac muscle contraction_Homo sapiens_hsa042601.15108210
59Phototransduction_Homo sapiens_hsa047441.14843522
60Gap junction_Homo sapiens_hsa045401.13549400
61Sphingolipid metabolism_Homo sapiens_hsa006001.12886732
62Ovarian steroidogenesis_Homo sapiens_hsa049131.11208332
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.10533255
64GnRH signaling pathway_Homo sapiens_hsa049121.10287418
65Ras signaling pathway_Homo sapiens_hsa040141.10272248
66Calcium signaling pathway_Homo sapiens_hsa040201.07824557
67Dorso-ventral axis formation_Homo sapiens_hsa043201.06721764
68Melanogenesis_Homo sapiens_hsa049161.04446020
69Taste transduction_Homo sapiens_hsa047421.04130965
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03866389
71RNA polymerase_Homo sapiens_hsa030201.03339032
72Proteoglycans in cancer_Homo sapiens_hsa052051.02231926
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01913834
74Dilated cardiomyopathy_Homo sapiens_hsa054141.01569878
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01519009
76RNA degradation_Homo sapiens_hsa030181.00998762
77MicroRNAs in cancer_Homo sapiens_hsa052061.00922913
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.00499560
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99819792
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98842113
81Oxidative phosphorylation_Homo sapiens_hsa001900.96795028
82Lysine degradation_Homo sapiens_hsa003100.96263291
83Hedgehog signaling pathway_Homo sapiens_hsa043400.95519812
84Choline metabolism in cancer_Homo sapiens_hsa052310.94032743
85Pyruvate metabolism_Homo sapiens_hsa006200.93160783
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.92015639
87Fanconi anemia pathway_Homo sapiens_hsa034600.91502609
88Melanoma_Homo sapiens_hsa052180.91490434
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91371064
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91083449
91Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90050682
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89445850
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87981382
94p53 signaling pathway_Homo sapiens_hsa041150.87302748
95Oocyte meiosis_Homo sapiens_hsa041140.86397642
96Estrogen signaling pathway_Homo sapiens_hsa049150.85502764
97Endocytosis_Homo sapiens_hsa041440.85177985
98Biosynthesis of amino acids_Homo sapiens_hsa012300.84100428
99Pancreatic secretion_Homo sapiens_hsa049720.82524936
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80513595
101Homologous recombination_Homo sapiens_hsa034400.79971875
102Alzheimers disease_Homo sapiens_hsa050100.79050938
103MAPK signaling pathway_Homo sapiens_hsa040100.77889515
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77200004
105Colorectal cancer_Homo sapiens_hsa052100.75859380
106Hippo signaling pathway_Homo sapiens_hsa043900.75285130
107* Wnt signaling pathway_Homo sapiens_hsa043100.73752543
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71722708
109Pathways in cancer_Homo sapiens_hsa052000.70608041
110Vitamin B6 metabolism_Homo sapiens_hsa007500.69892940
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69886259
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68488577
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68019905
114Rap1 signaling pathway_Homo sapiens_hsa040150.67718889
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67672426
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67183150
117Glioma_Homo sapiens_hsa052140.66508279
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65933663
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63474677
120Type II diabetes mellitus_Homo sapiens_hsa049300.63263177
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62932269
122ECM-receptor interaction_Homo sapiens_hsa045120.62046257
123Basal cell carcinoma_Homo sapiens_hsa052170.61076923
124Prostate cancer_Homo sapiens_hsa052150.60140783
125Focal adhesion_Homo sapiens_hsa045100.57426381
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57293463
127Purine metabolism_Homo sapiens_hsa002300.55692155
128Glucagon signaling pathway_Homo sapiens_hsa049220.53815635
129Circadian rhythm_Homo sapiens_hsa047100.53772102
130Butanoate metabolism_Homo sapiens_hsa006500.53395670
131Nucleotide excision repair_Homo sapiens_hsa034200.53225206
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52505451
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.51899665
134Small cell lung cancer_Homo sapiens_hsa052220.51675728
135Linoleic acid metabolism_Homo sapiens_hsa005910.51672487
136Base excision repair_Homo sapiens_hsa034100.50849249
137TGF-beta signaling pathway_Homo sapiens_hsa043500.47983267
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.46612202
139Parkinsons disease_Homo sapiens_hsa050120.46056117
140Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44500784
141VEGF signaling pathway_Homo sapiens_hsa043700.43393222
142Basal transcription factors_Homo sapiens_hsa030220.43115575
143Rheumatoid arthritis_Homo sapiens_hsa053230.42417069
144Thyroid hormone synthesis_Homo sapiens_hsa049180.42301398
145SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40371112
146Huntingtons disease_Homo sapiens_hsa050160.39879844
147Inositol phosphate metabolism_Homo sapiens_hsa005620.39478134
148alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38487888
149Prion diseases_Homo sapiens_hsa050200.36731692

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