PRICKLE2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a homolog of Drosophila prickle. The exact function of this gene is not known, however, studies in mice suggest that it may be involved in seizure prevention. Mutations in this gene are associated with progressive myoclonic epilepsy type 5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.07465440
2synaptic vesicle maturation (GO:0016188)5.70068827
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.66765744
4vocalization behavior (GO:0071625)5.48825844
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.44705914
6synaptic vesicle exocytosis (GO:0016079)5.28235563
7protein localization to synapse (GO:0035418)5.27735972
8locomotory exploration behavior (GO:0035641)5.15917009
9regulation of glutamate receptor signaling pathway (GO:1900449)4.92454945
10glutamate secretion (GO:0014047)4.92135198
11neuron cell-cell adhesion (GO:0007158)4.85936005
12regulation of synaptic vesicle exocytosis (GO:2000300)4.84781327
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.80921966
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.80324997
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.73820223
16neurotransmitter-gated ion channel clustering (GO:0072578)4.61931364
17neuronal action potential propagation (GO:0019227)4.55467229
18regulation of neuronal synaptic plasticity (GO:0048168)4.43195567
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.39854988
20regulation of synapse structural plasticity (GO:0051823)4.38081981
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.34718093
22synaptic transmission, glutamatergic (GO:0035249)4.34634723
23presynaptic membrane assembly (GO:0097105)4.33335600
24regulation of synaptic vesicle transport (GO:1902803)4.29785602
25glutamate receptor signaling pathway (GO:0007215)4.29687591
26postsynaptic membrane organization (GO:0001941)4.23481689
27dendritic spine morphogenesis (GO:0060997)4.22952336
28positive regulation of membrane potential (GO:0045838)4.21188214
29exploration behavior (GO:0035640)4.20472575
30regulation of excitatory postsynaptic membrane potential (GO:0060079)4.10234168
31neuron-neuron synaptic transmission (GO:0007270)4.09048034
32long-term memory (GO:0007616)3.97660269
33presynaptic membrane organization (GO:0097090)3.96424096
34neurotransmitter secretion (GO:0007269)3.87294576
35regulation of postsynaptic membrane potential (GO:0060078)3.86222729
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.82037849
37gamma-aminobutyric acid signaling pathway (GO:0007214)3.71575786
38regulation of dendritic spine morphogenesis (GO:0061001)3.69478191
39regulation of axon extension involved in axon guidance (GO:0048841)3.68259614
40layer formation in cerebral cortex (GO:0021819)3.67290054
41regulation of synaptic plasticity (GO:0048167)3.67037417
42neuron recognition (GO:0008038)3.64448110
43positive regulation of synaptic transmission, GABAergic (GO:0032230)3.61071409
44negative regulation of synaptic transmission, GABAergic (GO:0032229)3.60470714
45long-term synaptic potentiation (GO:0060291)3.59942069
46negative regulation of axon extension involved in axon guidance (GO:0048843)3.57675387
47positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.56539332
48positive regulation of neurotransmitter secretion (GO:0001956)3.55455489
49transmission of nerve impulse (GO:0019226)3.50986132
50positive regulation of synapse maturation (GO:0090129)3.50875709
51positive regulation of dendritic spine development (GO:0060999)3.49306919
52gamma-aminobutyric acid transport (GO:0015812)3.41481133
53regulation of axon guidance (GO:1902667)3.37829108
54positive regulation of neurotransmitter transport (GO:0051590)3.37416150
55regulation of synaptic transmission, glutamatergic (GO:0051966)3.35504624
56cellular potassium ion homeostasis (GO:0030007)3.35466237
57regulation of dendritic spine development (GO:0060998)3.35039361
58regulation of neurotransmitter secretion (GO:0046928)3.32813072
59axonal fasciculation (GO:0007413)3.32319895
60auditory behavior (GO:0031223)3.32250547
61L-amino acid import (GO:0043092)3.30515724
62regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.29982138
63synaptic vesicle endocytosis (GO:0048488)3.28458249
64neurotransmitter transport (GO:0006836)3.28162382
65G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.25869687
66endocrine hormone secretion (GO:0060986)3.25681292
67response to histamine (GO:0034776)3.25560421
68regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.24930776
69learning (GO:0007612)3.21999539
70behavioral defense response (GO:0002209)3.21327773
71behavioral fear response (GO:0001662)3.21327773
72negative regulation of cytosolic calcium ion concentration (GO:0051481)3.20085200
73membrane depolarization (GO:0051899)3.19838356
74synapse assembly (GO:0007416)3.16373844
75dendrite morphogenesis (GO:0048813)3.16303784
76positive regulation of dendritic spine morphogenesis (GO:0061003)3.14419708
77innervation (GO:0060384)3.13285599
78negative regulation of axon guidance (GO:1902668)3.12570828
79regulation of vesicle fusion (GO:0031338)3.11501089
80regulation of neurotransmitter transport (GO:0051588)3.10878704
81negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.10876324
82dendritic spine organization (GO:0097061)3.09859006
83membrane hyperpolarization (GO:0060081)3.09823136
84neuromuscular process controlling balance (GO:0050885)3.09686225
85response to auditory stimulus (GO:0010996)3.07055603
86positive regulation of synaptic transmission (GO:0050806)3.04688009
87regulation of voltage-gated calcium channel activity (GO:1901385)3.03527547
88axon extension involved in axon guidance (GO:0048846)3.03007770
89neuron projection extension involved in neuron projection guidance (GO:1902284)3.03007770
90ganglion development (GO:0061548)3.01600109
91regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.01404882
92proline transport (GO:0015824)3.00766502
93regulation of synaptic transmission, GABAergic (GO:0032228)3.00131729
94regulation of synaptic transmission (GO:0050804)2.99226944
95behavioral response to cocaine (GO:0048148)2.96767014
96mechanosensory behavior (GO:0007638)2.96340606
97fear response (GO:0042596)2.96273988
98regulation of neurotransmitter levels (GO:0001505)2.95042255
99central nervous system projection neuron axonogenesis (GO:0021952)2.94911444
100neuronal ion channel clustering (GO:0045161)2.93911997
101G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.92749753
102startle response (GO:0001964)2.92470693
103sodium ion export (GO:0071436)2.91347975
104synaptic transmission (GO:0007268)2.89570218
105pyrimidine nucleobase catabolic process (GO:0006208)2.89290203
106adult walking behavior (GO:0007628)2.89139728
107regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.86896565
108visual learning (GO:0008542)2.86148462
109regulation of synapse maturation (GO:0090128)2.86061883
110long term synaptic depression (GO:0060292)2.84804557
111membrane depolarization during action potential (GO:0086010)2.84288048
112positive regulation of cardiac muscle cell differentiation (GO:2000727)2.70766894
113membrane assembly (GO:0071709)2.69398497
114positive regulation of synapse assembly (GO:0051965)2.60017159
115negative chemotaxis (GO:0050919)2.59975564
116positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.58284001
117regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.53630130
118regulation of synapse assembly (GO:0051963)2.51774966
119central nervous system neuron axonogenesis (GO:0021955)2.45497807
120cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.44956070
121regulation of gonadotropin secretion (GO:0032276)2.44559799
122regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.41679094
123negative regulation of axon extension (GO:0030517)2.41406755
124axon extension (GO:0048675)2.41314437
125nucleobase catabolic process (GO:0046113)2.39048150
126regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.38209108
127detection of calcium ion (GO:0005513)2.37293497
128urinary tract smooth muscle contraction (GO:0014848)2.31420614
129positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.30366948
130cranial nerve structural organization (GO:0021604)2.29960711
131neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.28821820
132regulation of cell communication by electrical coupling (GO:0010649)2.28636138
133establishment of nucleus localization (GO:0040023)2.25574471
134positive regulation of macrophage activation (GO:0043032)2.25535777
135positive regulation of axon extension (GO:0045773)2.23273847
136positive regulation of actin filament depolymerization (GO:0030836)2.22023940
137cell communication by electrical coupling (GO:0010644)2.18843324
138regulation of synapse organization (GO:0050807)2.15858468
139glycosphingolipid biosynthetic process (GO:0006688)2.15622097
140cell communication involved in cardiac conduction (GO:0086065)2.15298466
141apical protein localization (GO:0045176)2.15221904
142regulation of cardiac muscle cell differentiation (GO:2000725)2.14866141
143negative regulation of dendrite development (GO:2000171)2.14503800
144peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.13684025
145regulation of cAMP-dependent protein kinase activity (GO:2000479)2.11973526
146neuronal action potential (GO:0019228)2.11409355
147positive regulation of protein autophosphorylation (GO:0031954)2.11063320
148facial nerve structural organization (GO:0021612)2.10118720
149regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.10029713
150cellular sodium ion homeostasis (GO:0006883)2.08372284
151regulation of axon extension (GO:0030516)2.07570054
152regulation of integrin-mediated signaling pathway (GO:2001044)2.05939570
153synapse organization (GO:0050808)2.04812390
154neuron projection extension (GO:1990138)2.04231711

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.06917481
2GBX2_23144817_ChIP-Seq_PC3_Human3.70642665
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.33109469
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.20166489
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.16425218
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.84830546
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.84830546
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.80856724
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.74334209
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.74219429
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.73051754
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.57475066
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.53609805
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.52812504
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50146017
16REST_21632747_ChIP-Seq_MESCs_Mouse2.45545456
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.39327781
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.37553594
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.36658698
20RARB_27405468_Chip-Seq_BRAIN_Mouse2.34279005
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.29311371
22DROSHA_22980978_ChIP-Seq_HELA_Human2.28442614
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.27683880
24TRIM28_21343339_ChIP-Seq_HEK293_Human2.07067868
25AR_21572438_ChIP-Seq_LNCaP_Human2.00400223
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.98917795
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.92630116
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84384060
29EP300_21415370_ChIP-Seq_HL-1_Mouse1.78481997
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77476793
31TAF15_26573619_Chip-Seq_HEK293_Human1.76937980
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.72946964
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72435616
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68161389
35ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.67602402
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.65400448
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.62472773
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.61931259
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60837099
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57640258
41* SMAD4_21799915_ChIP-Seq_A2780_Human1.57264899
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55017830
43* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54569366
44* CJUN_26792858_Chip-Seq_BT549_Human1.53482851
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.52955229
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51515672
47* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49146295
48P300_19829295_ChIP-Seq_ESCs_Human1.41440176
49NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.41213200
50NRF2_20460467_ChIP-Seq_MEFs_Mouse1.41213200
51* SMAD3_21741376_ChIP-Seq_EPCs_Human1.40864091
52RING1B_27294783_Chip-Seq_ESCs_Mouse1.40406806
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38275220
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.36861370
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36640049
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.34117420
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.33994568
58* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30345518
59* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.29737147
60* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26570300
61RING1B_27294783_Chip-Seq_NPCs_Mouse1.25143741
62* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24896800
63RNF2_27304074_Chip-Seq_NSC_Mouse1.24508951
64* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24364709
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24247233
66PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.23340119
67* AR_25329375_ChIP-Seq_VCAP_Human1.22648636
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21195923
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20690271
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.20665899
71RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20132365
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18719682
73ESR1_21235772_ChIP-Seq_MCF-7_Human1.17553319
74TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17346797
75BCAT_22108803_ChIP-Seq_LS180_Human1.17158037
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.16730827
77ESR1_20079471_ChIP-ChIP_T-47D_Human1.16393728
78CTNNB1_20460455_ChIP-Seq_HCT116_Human1.15198561
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14866182
80P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14253341
81* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13408820
82* STAT3_23295773_ChIP-Seq_U87_Human1.13321821
83RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12923512
84FUS_26573619_Chip-Seq_HEK293_Human1.11735286
85STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10108106
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09849790
87NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09578379
88ZNF274_21170338_ChIP-Seq_K562_Hela1.09491753
89ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09190087
90ESR2_21235772_ChIP-Seq_MCF-7_Human1.08379643
91* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08128293
92PRDM14_20953172_ChIP-Seq_ESCs_Human1.06779691
93AR_19668381_ChIP-Seq_PC3_Human1.05688548
94VDR_22108803_ChIP-Seq_LS180_Human1.05471621
95IGF1R_20145208_ChIP-Seq_DFB_Human1.04905637
96TCF4_23295773_ChIP-Seq_U87_Human1.04739005
97WT1_19549856_ChIP-ChIP_CCG9911_Human1.04489403
98* SMAD3_21741376_ChIP-Seq_HESCs_Human1.04366483
99POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04308379
100KDM2B_26808549_Chip-Seq_REH_Human1.03811078
101TCF4_18268006_ChIP-ChIP_LS174T_Human1.03669099
102EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03553156
103MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02695355
104ARNT_22903824_ChIP-Seq_MCF-7_Human1.02577551
105DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00802511
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00612769
107NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98626972
108WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97521267
109AHR_22903824_ChIP-Seq_MCF-7_Human0.97203431
110YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97080187
111* RUNX2_22187159_ChIP-Seq_PCA_Human0.95336606
112* ER_23166858_ChIP-Seq_MCF-7_Human0.92327006
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92155000
114* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91483348
115NANOG_18555785_Chip-Seq_ESCs_Mouse0.91023873
116TP53_16413492_ChIP-PET_HCT116_Human0.90404226
117* SMAD4_21741376_ChIP-Seq_HESCs_Human0.90402984
118TP53_18474530_ChIP-ChIP_U2OS_Human0.90016684
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89651812
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89651812
121TP53_20018659_ChIP-ChIP_R1E_Mouse0.88944558
122TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86457218
123TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85999959
124JUN_21703547_ChIP-Seq_K562_Human0.85765870
125SMAD3_21741376_ChIP-Seq_ESCs_Human0.84693879
126KDM2B_26808549_Chip-Seq_K562_Human0.84476587
127RXR_22108803_ChIP-Seq_LS180_Human0.83744214

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.46947544
2MP0003880_abnormal_central_pattern5.59755386
3MP0003635_abnormal_synaptic_transmissio4.04933410
4MP0004270_analgesia3.61483479
5MP0009745_abnormal_behavioral_response3.36872866
6MP0002063_abnormal_learning/memory/cond3.26150590
7MP0008438_abnormal_cutaneous_collagen3.18138901
8MP0001968_abnormal_touch/_nociception3.09207504
9MP0002064_seizures3.08866208
10MP0002822_catalepsy2.73818059
11MP0009046_muscle_twitch2.71935083
12MP0001486_abnormal_startle_reflex2.71418235
13MP0002572_abnormal_emotion/affect_behav2.70219750
14MP0002272_abnormal_nervous_system2.59566545
15MP0005423_abnormal_somatic_nervous2.58455131
16MP0005275_abnormal_skin_tensile2.57449950
17MP0002734_abnormal_mechanical_nocicepti2.44883458
18MP0005503_abnormal_tendon_morphology2.41610440
19MP0002736_abnormal_nociception_after2.18614292
20MP0003136_yellow_coat_color2.18467501
21MP0001188_hyperpigmentation2.18459160
22MP0005409_darkened_coat_color2.11974146
23MP0001501_abnormal_sleep_pattern2.02000316
24MP0001440_abnormal_grooming_behavior1.98837130
25MP0005187_abnormal_penis_morphology1.97343280
26MP0002735_abnormal_chemical_nociception1.96802193
27MP0000778_abnormal_nervous_system1.91342612
28MP0001299_abnormal_eye_distance/1.90748196
29MP0002067_abnormal_sensory_capabilities1.90606172
30MP0008569_lethality_at_weaning1.89580593
31MP0001970_abnormal_pain_threshold1.85920516
32MP0004272_abnormal_basement_membrane1.82310955
33MP0005646_abnormal_pituitary_gland1.72800792
34MP0002733_abnormal_thermal_nociception1.71068690
35MP0002557_abnormal_social/conspecific_i1.67385440
36MP0002184_abnormal_innervation1.65495501
37MP0000569_abnormal_digit_pigmentation1.58905114
38MP0003950_abnormal_plasma_membrane1.56556130
39MP0004811_abnormal_neuron_physiology1.56310887
40MP0004924_abnormal_behavior1.51232094
41MP0005386_behavior/neurological_phenoty1.51232094
42MP0000955_abnormal_spinal_cord1.46076918
43MP0002882_abnormal_neuron_morphology1.45573266
44MP0003879_abnormal_hair_cell1.45231822
45MP0004885_abnormal_endolymph1.45113521
46MP0005670_abnormal_white_adipose1.44539649
47MP0001984_abnormal_olfaction1.43578149
48MP0005551_abnormal_eye_electrophysiolog1.43541959
49MP0002876_abnormal_thyroid_physiology1.41889225
50MP0001905_abnormal_dopamine_level1.40693559
51MP0001958_emphysema1.39056924
52MP0006276_abnormal_autonomic_nervous1.38557165
53MP0009780_abnormal_chondrocyte_physiolo1.36811228
54MP0001529_abnormal_vocalization1.34267269
55MP0004858_abnormal_nervous_system1.32672103
56MP0000013_abnormal_adipose_tissue1.32658581
57MP0002066_abnormal_motor_capabilities/c1.32507586
58MP0003329_amyloid_beta_deposits1.32048556
59MP0002295_abnormal_pulmonary_circulatio1.31902948
60MP0002909_abnormal_adrenal_gland1.29995337
61MP0003633_abnormal_nervous_system1.29155260
62MP0000534_abnormal_ureter_morphology1.27897225
63MP0003787_abnormal_imprinting1.25518650
64MP0004142_abnormal_muscle_tone1.24929503
65MP0001502_abnormal_circadian_rhythm1.22969521
66MP0003279_aneurysm1.16798842
67MP0000920_abnormal_myelination1.14037863
68MP0002108_abnormal_muscle_morphology1.12216378
69MP0010368_abnormal_lymphatic_system1.11471609
70MP0001177_atelectasis1.08745370
71MP0005171_absent_coat_pigmentation1.08672205
72MP0002152_abnormal_brain_morphology1.07591615
73MP0000749_muscle_degeneration1.07218759
74MP0004742_abnormal_vestibular_system1.06892471
75MP0000462_abnormal_digestive_system1.05587374
76MP0006292_abnormal_olfactory_placode1.04787441
77MP0003631_nervous_system_phenotype1.03542338
78MP0005645_abnormal_hypothalamus_physiol1.01570799
79MP0002229_neurodegeneration1.00119287
80MP0000631_abnormal_neuroendocrine_gland0.97606184
81MP0001963_abnormal_hearing_physiology0.97172692
82MP0005499_abnormal_olfactory_system0.96911482
83MP0005394_taste/olfaction_phenotype0.96911482
84MP0002752_abnormal_somatic_nervous0.91429764
85MP0000516_abnormal_urinary_system0.90222102
86MP0005367_renal/urinary_system_phenotyp0.90222102
87MP0003075_altered_response_to0.89885165
88MP0001879_abnormal_lymphatic_vessel0.89386914
89MP0005508_abnormal_skeleton_morphology0.87634248
90MP0003634_abnormal_glial_cell0.87105659
91MP0000538_abnormal_urinary_bladder0.86955351
92MP0003690_abnormal_glial_cell0.86574554
93MP0000751_myopathy0.86176566
94MP0002090_abnormal_vision0.84987962
95MP0003941_abnormal_skin_development0.84987217
96MP0003942_abnormal_urinary_system0.84694680
97MP0005248_abnormal_Harderian_gland0.84505534
98MP0005620_abnormal_muscle_contractility0.83617090
99MP0002638_abnormal_pupillary_reflex0.82430898
100MP0001485_abnormal_pinna_reflex0.81544535
101MP0008874_decreased_physiological_sensi0.80582717
102MP0002896_abnormal_bone_mineralization0.80463483
103MP0002069_abnormal_eating/drinking_beha0.80361252
104MP0002282_abnormal_trachea_morphology0.79731989
105MP0003385_abnormal_body_wall0.79295265
106MP0004145_abnormal_muscle_electrophysio0.79162970
107MP0000579_abnormal_nail_morphology0.78416564
108MP0003122_maternal_imprinting0.77957008
109MP0003283_abnormal_digestive_organ0.77314500
110MP0008872_abnormal_physiological_respon0.75962424
111MP0009250_abnormal_appendicular_skeleto0.75950240
112MP0003868_abnormal_feces_composition0.75139476
113MP0004484_altered_response_of0.75013692
114MP0003938_abnormal_ear_development0.74961941
115MP0006072_abnormal_retinal_apoptosis0.74446320
116MP0001664_abnormal_digestion0.73745552
117MP0000427_abnormal_hair_cycle0.73426116
118MP0004085_abnormal_heartbeat0.73049412
119MP0004084_abnormal_cardiac_muscle0.73026172
120MP0006054_spinal_hemorrhage0.71894989
121MP0003137_abnormal_impulse_conducting0.71160110
122MP0000026_abnormal_inner_ear0.69559501
123MP0010386_abnormal_urinary_bladder0.67375285
124MP0004215_abnormal_myocardial_fiber0.66912247
125MP0000767_abnormal_smooth_muscle0.66650939
126MP0005623_abnormal_meninges_morphology0.66571681
127MP0003755_abnormal_palate_morphology0.66060988
128MP0005253_abnormal_eye_physiology0.62667363
129MP0003632_abnormal_nervous_system0.61847275
130MP0000015_abnormal_ear_pigmentation0.60907992
131MP0002751_abnormal_autonomic_nervous0.59116109
132MP0003861_abnormal_nervous_system0.58573770
133MP0001943_abnormal_respiration0.57374558
134MP0005167_abnormal_blood-brain_barrier0.56167669
135MP0005595_abnormal_vascular_smooth0.55409527
136MP0009379_abnormal_foot_pigmentation0.54422962
137MP0001346_abnormal_lacrimal_gland0.54342624
138MP0005535_abnormal_body_temperature0.53267056
139MP0005195_abnormal_posterior_eye0.53096452
140MP0004043_abnormal_pH_regulation0.51392691

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.33391364
2Myokymia (HP:0002411)7.50166220
3Focal seizures (HP:0007359)5.59387002
4Epileptic encephalopathy (HP:0200134)5.23545530
5Visual hallucinations (HP:0002367)4.47454685
6Febrile seizures (HP:0002373)4.46596168
7Progressive cerebellar ataxia (HP:0002073)4.22412498
8Atonic seizures (HP:0010819)4.15613341
9Broad-based gait (HP:0002136)3.96540429
10Absence seizures (HP:0002121)3.89461660
11Dialeptic seizures (HP:0011146)3.88264369
12Action tremor (HP:0002345)3.74376973
13Hyperventilation (HP:0002883)3.60030866
14Gaze-evoked nystagmus (HP:0000640)3.45113392
15Generalized tonic-clonic seizures (HP:0002069)3.42007744
16Supranuclear gaze palsy (HP:0000605)3.37619373
17Ankle clonus (HP:0011448)3.28894246
18Aortic dissection (HP:0002647)3.21526538
19* Dysmetria (HP:0001310)3.19046772
20Aortic aneurysm (HP:0004942)3.15800324
21Vascular tortuosity (HP:0004948)3.13371634
22Follicular hyperkeratosis (HP:0007502)3.08203869
23Scanning speech (HP:0002168)3.06904674
24Arterial tortuosity (HP:0005116)3.04959303
25Dysdiadochokinesis (HP:0002075)3.04439097
26Depression (HP:0000716)3.04255772
27Poor eye contact (HP:0000817)3.00621928
28Mutism (HP:0002300)2.92031824
29Amblyopia (HP:0000646)2.91761358
30Excessive salivation (HP:0003781)2.91423979
31Drooling (HP:0002307)2.91423979
32Abnormal eating behavior (HP:0100738)2.84047741
33Impaired vibration sensation in the lower limbs (HP:0002166)2.83693833
34Neurofibrillary tangles (HP:0002185)2.81707300
35Anxiety (HP:0000739)2.80876261
36Papilledema (HP:0001085)2.70365439
37Urinary bladder sphincter dysfunction (HP:0002839)2.64674405
38Truncal ataxia (HP:0002078)2.63690082
39Obstructive sleep apnea (HP:0002870)2.62733061
40Absent speech (HP:0001344)2.61082395
41Broad metatarsal (HP:0001783)2.57767876
42Hemiparesis (HP:0001269)2.57210005
43Impaired social interactions (HP:0000735)2.57036095
44Abnormal social behavior (HP:0012433)2.57036095
45Premature rupture of membranes (HP:0001788)2.56225097
46Progressive inability to walk (HP:0002505)2.50788434
47Atrophic scars (HP:0001075)2.50183533
48Megalencephaly (HP:0001355)2.49866647
49Torticollis (HP:0000473)2.48450833
50Intention tremor (HP:0002080)2.48433001
51Spastic gait (HP:0002064)2.45008499
52Postural instability (HP:0002172)2.44765850
53Genetic anticipation (HP:0003743)2.42414601
54Cerebral inclusion bodies (HP:0100314)2.40594044
55Stereotypic behavior (HP:0000733)2.35684616
56Retinal dysplasia (HP:0007973)2.29154641
57Focal dystonia (HP:0004373)2.29005906
58Impaired smooth pursuit (HP:0007772)2.26349772
59Diplopia (HP:0000651)2.25346455
60Abnormality of binocular vision (HP:0011514)2.25346455
61Epileptiform EEG discharges (HP:0011182)2.24638513
62Annular pancreas (HP:0001734)2.23705466
63Absent frontal sinuses (HP:0002688)2.22675661
64Ventricular fibrillation (HP:0001663)2.20504539
65Urinary urgency (HP:0000012)2.17107666
66Blue irides (HP:0000635)2.16832981
67Limb dystonia (HP:0002451)2.16288420
68Soft skin (HP:0000977)2.12443054
69Fetal akinesia sequence (HP:0001989)2.11490350
70Inability to walk (HP:0002540)2.11061521
71Buphthalmos (HP:0000557)2.11045843
72Aplasia involving bones of the upper limbs (HP:0009823)2.10920716
73Aplasia of the phalanges of the hand (HP:0009802)2.10920716
74Aplasia involving bones of the extremities (HP:0009825)2.10920716
75Protrusio acetabuli (HP:0003179)2.10317979
76Bradykinesia (HP:0002067)2.09123332
77Termporal pattern (HP:0011008)2.08801206
78Insidious onset (HP:0003587)2.08801206
79Sleep apnea (HP:0010535)2.06352571
80Impaired vibratory sensation (HP:0002495)2.05311241
81Cerebral aneurysm (HP:0004944)2.04234078
82Hypothermia (HP:0002045)2.03397164
83Abnormality of salivation (HP:0100755)2.02913209
84Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.00694343
85Incomplete penetrance (HP:0003829)2.00238619
86Peripheral hypomyelination (HP:0007182)2.00080120
87Thyroid-stimulating hormone excess (HP:0002925)1.98882800
88Abnormality of the corticospinal tract (HP:0002492)1.98650099
89EEG with generalized epileptiform discharges (HP:0011198)1.98539675
90Bradycardia (HP:0001662)1.98345533
91Craniofacial dystonia (HP:0012179)1.97813101
92Polyphagia (HP:0002591)1.97612450
93Hemiplegia (HP:0002301)1.97223237
94Lower limb muscle weakness (HP:0007340)1.97033305
95Delayed gross motor development (HP:0002194)1.93612161
96Thickened helices (HP:0000391)1.88683004
97Shallow orbits (HP:0000586)1.87922050
98Neoplasm of the heart (HP:0100544)1.87888022
99Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.86819929
100Heterochromia iridis (HP:0001100)1.85652052
101Abnormality of the ischium (HP:0003174)1.85622626
102Abnormality of ocular smooth pursuit (HP:0000617)1.85595918
103Hypoplasia of the iris (HP:0007676)1.85053303
104Absent/shortened dynein arms (HP:0200106)1.84837273
105Dynein arm defect of respiratory motile cilia (HP:0012255)1.84837273
106Hyporeflexia of lower limbs (HP:0002600)1.83980081
107Abnormality of dentin (HP:0010299)1.83438974
108Hypsarrhythmia (HP:0002521)1.81046704
109Wrist flexion contracture (HP:0001239)1.80031050
110Limited hip movement (HP:0008800)1.77967831
111Cutaneous finger syndactyly (HP:0010554)1.77407706
112Abnormal EKG (HP:0003115)1.76728787
113Gait ataxia (HP:0002066)1.76491409
114Atrial fibrillation (HP:0005110)1.73841850
115Degeneration of the lateral corticospinal tracts (HP:0002314)1.73829209
116Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.73829209
117Coronal craniosynostosis (HP:0004440)1.73458910
118Hypoventilation (HP:0002791)1.72663384
119Enlarged penis (HP:0000040)1.72105844
120Delusions (HP:0000746)1.70350637
121Rhinitis (HP:0012384)1.70135513
122Specific learning disability (HP:0001328)1.69767994
123Syncope (HP:0001279)1.69453330
124Protruding tongue (HP:0010808)1.69295844
125Abnormality of the lower motor neuron (HP:0002366)1.69183835
126Infantile muscular hypotonia (HP:0008947)1.69058272
127* Generalized myoclonic seizures (HP:0002123)1.68707873
128Bladder diverticulum (HP:0000015)1.68683691
129Iris hypopigmentation (HP:0007730)1.67602373
130Striae distensae (HP:0001065)1.67584960
131Tubulointerstitial nephritis (HP:0001970)1.66337004
132Abnormal ciliary motility (HP:0012262)1.65648417
133Neuronal loss in central nervous system (HP:0002529)1.65034091
134Gait imbalance (HP:0002141)1.64333375
135Agitation (HP:0000713)1.64100066
136Prolonged QT interval (HP:0001657)1.63312396
137Congenital stationary night blindness (HP:0007642)1.63292445
138Status epilepticus (HP:0002133)1.62952690
139Esotropia (HP:0000565)1.62894694
140Genital tract atresia (HP:0001827)1.62099501
141Prominent supraorbital ridges (HP:0000336)1.60765651
142Alopecia of scalp (HP:0002293)1.60763933
143Ulnar claw (HP:0001178)1.60472598
144Bell-shaped thorax (HP:0001591)1.60212914
145Overgrowth (HP:0001548)1.59882307
146Primary atrial arrhythmia (HP:0001692)1.56996566
147Renal hypoplasia (HP:0000089)1.56433630
148Bundle branch block (HP:0011710)1.53696302
149Keratoconus (HP:0000563)1.53428675
150Increased corneal curvature (HP:0100692)1.53428675
151Vaginal atresia (HP:0000148)1.53415217
152Wormian bones (HP:0002645)1.52206901
153Abnormality of the frontal sinuses (HP:0002687)1.52187746
154Abnormal respiratory epithelium morphology (HP:0012253)1.52136276
155Abnormal respiratory motile cilium morphology (HP:0005938)1.52136276
156Shawl scrotum (HP:0000049)1.50713067
157Lymphangioma (HP:0100764)1.50269166
158Macroorchidism (HP:0000053)1.49768643
159Tented upper lip vermilion (HP:0010804)1.47595820
160Congenital glaucoma (HP:0001087)1.46702831
161Hyperextensible skin (HP:0000974)1.45036926
162Metaphyseal dysplasia (HP:0100255)1.44943414
163Supraventricular arrhythmia (HP:0005115)1.44479033
164Abnormality of the calf musculature (HP:0001430)1.43930282
165Hamartoma of the eye (HP:0010568)1.43769788
166Microglossia (HP:0000171)1.43586387

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.02659542
2NTRK34.04088760
3CASK3.89812552
4MAP3K93.06000175
5FRK3.00312522
6MARK12.82805282
7DAPK22.51711835
8TNIK2.51481395
9MAP3K42.41858317
10MYLK2.36283018
11MINK12.35771395
12MAP2K72.35704796
13PAK62.11828811
14PRPF4B2.06133212
15PRKD31.99302273
16NTRK21.90806004
17CDK191.86345652
18KSR21.86239577
19RIPK41.83182991
20FGFR21.73366325
21ARAF1.60458844
22NTRK11.57828707
23MAP3K121.55348203
24CDK51.54440837
25CAMKK11.54100415
26STK381.52733665
27ERBB31.52470566
28PIK3CA1.50897048
29FES1.43708645
30STK38L1.43248017
31LIMK11.43030872
32MAPK131.40571284
33DAPK11.37495929
34KSR11.36881602
35UHMK11.36425923
36MAP2K41.32261617
37WNK31.30354324
38OXSR11.29718252
39PLK21.29538242
40EPHB21.28630480
41GRK51.26915250
42CAMK2B1.23643812
43CAMK2A1.22521103
44PDGFRA1.15533091
45MAP4K21.14952894
46PTK21.11902931
47PRKCG1.10809510
48CAMK11.08754761
49MAP3K21.07564763
50ROCK11.07294674
51SGK2231.03983443
52SGK4941.03983443
53ADRBK21.02638696
54MAP3K131.01360802
55PHKG11.00308162
56PHKG21.00308162
57MAPK151.00127431
58STK390.94731519
59BMPR1B0.94523598
60EPHA30.93983229
61LATS10.93910425
62BMPR20.93707882
63PAK20.93389751
64STK110.92489222
65EIF2AK30.90986686
66CDK180.89004836
67MARK20.88441922
68PTK2B0.88290509
69CDK140.88090651
70CDK150.87510455
71DYRK1A0.87343135
72NME10.87070130
73ADRBK10.86597082
74RAF10.86170236
75DDR20.83173838
76MET0.80947509
77FGR0.80714757
78CAMK1G0.79068058
79TYRO30.78733743
80PNCK0.78110226
81CDK11A0.77884843
82SIK20.76075770
83TIE10.74467837
84MAP3K10.74011442
85CAMK2D0.72898613
86PRKD20.71602935
87MAP2K10.70678409
88NEK60.69822887
89CAMKK20.69229050
90SGK20.69144317
91CCNB10.68081443
92PDGFRB0.67220505
93PAK30.65307808
94SGK10.64882837
95LATS20.64101827
96TESK10.63971865
97DYRK20.61842056
98GRK10.61694580
99MAP3K70.61478420
100MAPKAPK50.61017893
101CSNK1G20.60382144
102PRKCE0.59772903
103CAMK2G0.59724601
104LMTK20.59572573
105TAOK10.58088428
106MUSK0.58012019
107PDK10.57217208
108AKT30.56934714
109FER0.56233137
110PRKCH0.56149190
111TNK20.55356228
112ERBB20.55116733
113PDPK10.54827238
114OBSCN0.54300578
115PKN10.53208815
116MKNK20.52848066
117PINK10.51949274
118CSNK1A1L0.51912239
119PKN20.50915628
120PRKD10.47921293
121SGK30.47878845
122ROCK20.47653088
123BCR0.47253084
124RET0.46355011
125FYN0.45921009
126CAMK40.44754961
127DAPK30.44681613
128WNK10.44593385
129RIPK10.43795810
130TRIM280.42936709
131MAPK100.41924922
132CDK30.41875500
133PRKCZ0.41579152
134BRAF0.41412671
135CSNK1D0.40314948
136RPS6KA30.40285853
137GRK70.39652256
138CSNK1G10.39493823
139IRAK20.38859823
140GSK3A0.37921529
141DMPK0.36140884
142PRKG10.34356519
143MAPK120.33109464

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.94774039
2Synaptic vesicle cycle_Homo sapiens_hsa047213.07558626
3Circadian entrainment_Homo sapiens_hsa047132.83008443
4Olfactory transduction_Homo sapiens_hsa047402.82512878
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.80056532
6GABAergic synapse_Homo sapiens_hsa047272.79435174
7Glutamatergic synapse_Homo sapiens_hsa047242.73682670
8Morphine addiction_Homo sapiens_hsa050322.69299081
9Long-term potentiation_Homo sapiens_hsa047202.66809915
10Amphetamine addiction_Homo sapiens_hsa050312.49400753
11Salivary secretion_Homo sapiens_hsa049702.29396882
12Dopaminergic synapse_Homo sapiens_hsa047282.13872677
13Cholinergic synapse_Homo sapiens_hsa047252.00496632
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.97285504
15Insulin secretion_Homo sapiens_hsa049111.92754512
16Gastric acid secretion_Homo sapiens_hsa049711.88797795
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.85971737
18Serotonergic synapse_Homo sapiens_hsa047261.82854174
19Long-term depression_Homo sapiens_hsa047301.79256804
20ECM-receptor interaction_Homo sapiens_hsa045121.76597869
21Renin secretion_Homo sapiens_hsa049241.76177303
22Calcium signaling pathway_Homo sapiens_hsa040201.72455103
23Taste transduction_Homo sapiens_hsa047421.71460207
24Oxytocin signaling pathway_Homo sapiens_hsa049211.69106554
25Cocaine addiction_Homo sapiens_hsa050301.60979270
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58189684
27GnRH signaling pathway_Homo sapiens_hsa049121.48110660
28Collecting duct acid secretion_Homo sapiens_hsa049661.40537352
29Phototransduction_Homo sapiens_hsa047441.39505473
30Gap junction_Homo sapiens_hsa045401.39293177
31Axon guidance_Homo sapiens_hsa043601.38041819
32cAMP signaling pathway_Homo sapiens_hsa040241.35212051
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32758054
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28393009
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27442328
36Melanogenesis_Homo sapiens_hsa049161.25462921
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22042149
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.18019619
39Focal adhesion_Homo sapiens_hsa045101.17150805
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12849275
41ErbB signaling pathway_Homo sapiens_hsa040121.08705872
42Hippo signaling pathway_Homo sapiens_hsa043901.07989382
43Glioma_Homo sapiens_hsa052141.06758165
44Protein digestion and absorption_Homo sapiens_hsa049741.06587629
45Cardiac muscle contraction_Homo sapiens_hsa042601.03887590
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03033763
47Vascular smooth muscle contraction_Homo sapiens_hsa042701.01499233
48Hedgehog signaling pathway_Homo sapiens_hsa043401.00915663
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96522934
50Estrogen signaling pathway_Homo sapiens_hsa049150.95907044
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93196147
52TGF-beta signaling pathway_Homo sapiens_hsa043500.92987842
53Vibrio cholerae infection_Homo sapiens_hsa051100.91333209
54Pancreatic secretion_Homo sapiens_hsa049720.90509294
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.89363774
56Adherens junction_Homo sapiens_hsa045200.88470973
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86337335
58Type II diabetes mellitus_Homo sapiens_hsa049300.81497763
59Choline metabolism in cancer_Homo sapiens_hsa052310.77588567
60beta-Alanine metabolism_Homo sapiens_hsa004100.76961771
61Melanoma_Homo sapiens_hsa052180.74829000
62Ras signaling pathway_Homo sapiens_hsa040140.74383850
63MAPK signaling pathway_Homo sapiens_hsa040100.74176025
64Vitamin B6 metabolism_Homo sapiens_hsa007500.73797535
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72344932
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71592547
67Histidine metabolism_Homo sapiens_hsa003400.71562785
68Dorso-ventral axis formation_Homo sapiens_hsa043200.71553793
69Dilated cardiomyopathy_Homo sapiens_hsa054140.70859947
70Fatty acid biosynthesis_Homo sapiens_hsa000610.70843417
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70476648
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69845497
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69402568
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68155176
75Rap1 signaling pathway_Homo sapiens_hsa040150.68104006
76Proteoglycans in cancer_Homo sapiens_hsa052050.67602599
77Oocyte meiosis_Homo sapiens_hsa041140.66684545
78Basal cell carcinoma_Homo sapiens_hsa052170.66109390
79Thyroid hormone synthesis_Homo sapiens_hsa049180.64836581
80Nitrogen metabolism_Homo sapiens_hsa009100.62938957
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62526097
82VEGF signaling pathway_Homo sapiens_hsa043700.61827294
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.61503977
84Butanoate metabolism_Homo sapiens_hsa006500.61383906
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60464019
86Bile secretion_Homo sapiens_hsa049760.59061444
87Amoebiasis_Homo sapiens_hsa051460.58471443
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58425945
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58417747
90African trypanosomiasis_Homo sapiens_hsa051430.57398534
91* Wnt signaling pathway_Homo sapiens_hsa043100.56299684
92Sphingolipid metabolism_Homo sapiens_hsa006000.54648954
93PPAR signaling pathway_Homo sapiens_hsa033200.54578392
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54245920
95Inositol phosphate metabolism_Homo sapiens_hsa005620.53486714
96Alzheimers disease_Homo sapiens_hsa050100.52633868
97Alcoholism_Homo sapiens_hsa050340.51889940
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49816002
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49381044
100ABC transporters_Homo sapiens_hsa020100.47749385
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47597613
102Endocytosis_Homo sapiens_hsa041440.46910868
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.46442445
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45258066
105Circadian rhythm_Homo sapiens_hsa047100.45008759
106Propanoate metabolism_Homo sapiens_hsa006400.44948926
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44900100
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43297896
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43132372
110Endometrial cancer_Homo sapiens_hsa052130.42268180
111Renal cell carcinoma_Homo sapiens_hsa052110.42165122
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41846025
113Ether lipid metabolism_Homo sapiens_hsa005650.41830764
114Ovarian steroidogenesis_Homo sapiens_hsa049130.40399465
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38209944
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37709331
117Non-small cell lung cancer_Homo sapiens_hsa052230.34134275
118Chemokine signaling pathway_Homo sapiens_hsa040620.33341831
119Mineral absorption_Homo sapiens_hsa049780.33096593
120Type I diabetes mellitus_Homo sapiens_hsa049400.32681488
121Glucagon signaling pathway_Homo sapiens_hsa049220.31383146
122Prion diseases_Homo sapiens_hsa050200.31069274
123Oxidative phosphorylation_Homo sapiens_hsa001900.30355505
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30345268
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30108156
126Tight junction_Homo sapiens_hsa045300.29978935
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28390696
128Rheumatoid arthritis_Homo sapiens_hsa053230.26877190
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24625445
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.22991423

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