ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	7.96808080
2	ATP synthesis coupled proton transport (GO:0015986)	6.99859775
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.99859775
4	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.98681212
5	chaperone-mediated protein transport (GO:0072321)	5.84955429
6	viral transcription (GO:0019083)	5.79645469
7	respiratory electron transport chain (GO:0022904)	5.72475754
8	electron transport chain (GO:0022900)	5.65194238
9	translational termination (GO:0006415)	5.65082852
10	ribosomal small subunit biogenesis (GO:0042274)	5.58328318
11	ribosomal large subunit biogenesis (GO:0042273)	5.54249682
12	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.47564179
13	cotranslational protein targeting to membrane (GO:0006613)	5.41771993
14	proteasome assembly (GO:0043248)	5.41380523
15	protein targeting to ER (GO:0045047)	5.38728921
16	protein complex biogenesis (GO:0070271)	5.33616754
17	transcription elongation from RNA polymerase III promoter (GO:0006385)	5.21506780
18	termination of RNA polymerase III transcription (GO:0006386)	5.21506780
19	mitochondrial respiratory chain complex assembly (GO:0033108)	5.20518842
20	rRNA modification (GO:0000154)	5.18995780
21	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.16681165
22	protein localization to endoplasmic reticulum (GO:0070972)	5.12420763
23	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.11889166
24	locomotory exploration behavior (GO:0035641)	5.00277908
25	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.88334476
26	NADH dehydrogenase complex assembly (GO:0010257)	4.88334476
27	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.88334476
28	translational elongation (GO:0006414)	4.85389290
29	rRNA methylation (GO:0031167)	4.83344475
30	regulation of mitochondrial translation (GO:0070129)	4.68946411
31	maturation of SSU-rRNA (GO:0030490)	4.61366295
32	translation (GO:0006412)	4.58339537
33	cellular modified amino acid catabolic process (GO:0042219)	4.53058203
34	viral life cycle (GO:0019058)	4.45035963
35	ribosomal small subunit assembly (GO:0000028)	4.44123357
36	translational initiation (GO:0006413)	4.41361263
37	coenzyme catabolic process (GO:0009109)	4.37752703
38	protein neddylation (GO:0045116)	4.34522008
39	cellular protein complex disassembly (GO:0043624)	4.32673377
40	C4-dicarboxylate transport (GO:0015740)	4.31634621
41	glutamate secretion (GO:0014047)	4.23383344
42	respiratory chain complex IV assembly (GO:0008535)	4.20051294
43	protein targeting to mitochondrion (GO:0006626)	4.14885606
44	water-soluble vitamin biosynthetic process (GO:0042364)	4.13322072
45	alpha-linolenic acid metabolic process (GO:0036109)	4.09653926
46	dicarboxylic acid biosynthetic process (GO:0043650)	4.09343057
47	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.07961212
48	cytochrome complex assembly (GO:0017004)	4.03075840
49	synaptic vesicle maturation (GO:0016188)	4.00490722
50	negative regulation of amyloid precursor protein catabolic process (GO:1902992)	3.98370907
51	cellular component biogenesis (GO:0044085)	3.97222587
52	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.96345054
53	regulation of oxidative phosphorylation (GO:0002082)	3.85386696
54	sulfur amino acid catabolic process (GO:0000098)	3.82144789
55	ribonucleoprotein complex biogenesis (GO:0022613)	3.81588062
56	L-amino acid import (GO:0043092)	3.77532505
57	hydrogen ion transmembrane transport (GO:1902600)	3.74333523
58	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.73534998
59	transcription elongation from RNA polymerase I promoter (GO:0006362)	3.72092788
60	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.71312574
61	establishment of protein localization to mitochondrion (GO:0072655)	3.71263984
62	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.71031219
63	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.68791708
64	L-phenylalanine metabolic process (GO:0006558)	3.68791708
65	ATP biosynthetic process (GO:0006754)	3.68107629
66	protein localization to mitochondrion (GO:0070585)	3.67145416
67	rRNA processing (GO:0006364)	3.66894320
68	negative regulation of ligase activity (GO:0051352)	3.66073185
69	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.66073185
70	L-phenylalanine catabolic process (GO:0006559)	3.63461777
71	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.63461777
72	cullin deneddylation (GO:0010388)	3.60440589
73	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.59731992
74	regulation of cellular amino acid metabolic process (GO:0006521)	3.59411100
75	protein targeting to membrane (GO:0006612)	3.58788644
76	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.55451554
77	protein complex disassembly (GO:0043241)	3.54532725
78	CDP-diacylglycerol biosynthetic process (GO:0016024)	3.54255130
79	CDP-diacylglycerol metabolic process (GO:0046341)	3.54192684
80	rRNA metabolic process (GO:0016072)	3.52664374
81	glutamate metabolic process (GO:0006536)	3.52630644
82	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.50545161
83	exploration behavior (GO:0035640)	3.49927677
84	pseudouridine synthesis (GO:0001522)	3.47410247
85	lysine catabolic process (GO:0006554)	3.46206758
86	lysine metabolic process (GO:0006553)	3.46206758
87	macromolecular complex disassembly (GO:0032984)	3.43332131
88	transcription from RNA polymerase I promoter (GO:0006360)	3.43193815
89	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.43064012
90	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.42729736
91	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.42729736
92	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.39668255
93	termination of RNA polymerase I transcription (GO:0006363)	3.39637945
94	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.35162265
95	proton transport (GO:0015992)	3.33606650
96	spliceosomal snRNP assembly (GO:0000387)	3.33526001
97	protein-cofactor linkage (GO:0018065)	3.32422086
98	aspartate family amino acid catabolic process (GO:0009068)	3.31934054
99	mitochondrial transport (GO:0006839)	3.31463001
100	synaptic vesicle docking involved in exocytosis (GO:0016081)	3.30290191
101	protein deneddylation (GO:0000338)	3.30061570
102	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	3.29441543
103	hydrogen transport (GO:0006818)	3.28979304
104	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.28660777
105	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.28660777
106	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.28660777
107	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.28113891
108	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.28113891
109	7-methylguanosine mRNA capping (GO:0006370)	3.27539776
110	synaptic vesicle exocytosis (GO:0016079)	3.25999888
111	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.22568291
112	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.19365131
113	regulation of cholesterol homeostasis (GO:2000188)	3.19054265
114	7-methylguanosine RNA capping (GO:0009452)	3.18738186
115	RNA capping (GO:0036260)	3.18738186
116	reverse cholesterol transport (GO:0043691)	3.16833311
117	negative regulation of potassium ion transmembrane transport (GO:1901380)	3.16627457
118	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.15689134
119	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.15590690
120	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.15590690
121	positive regulation of triglyceride biosynthetic process (GO:0010867)	3.14870600
122	negative regulation of protein oligomerization (GO:0032460)	3.14239850
123	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.13841178
124	auditory behavior (GO:0031223)	3.12179287
125	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.11241133
126	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.07951238
127	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	3.07859674
128	positive regulation of ligase activity (GO:0051351)	3.07776137
129	kynurenine metabolic process (GO:0070189)	3.07251606
130	cell communication by electrical coupling (GO:0010644)	3.06691358
131	response to auditory stimulus (GO:0010996)	3.05481173
132	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.04041451
133	mRNA catabolic process (GO:0006402)	3.02941197
134	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	3.01810452
135	tRNA processing (GO:0008033)	3.00486824
136	transcription-coupled nucleotide-excision repair (GO:0006283)	3.00307776
137	regulation of beta-amyloid formation (GO:1902003)	2.99709616
138	ethanol oxidation (GO:0006069)	2.98368012
139	dicarboxylic acid catabolic process (GO:0043649)	2.97925745
140	sodium ion export (GO:0071436)	2.97913028
141	mannosylation (GO:0097502)	2.97153107
142	DNA catabolic process, exonucleolytic (GO:0000738)	2.96758384
143	intracellular protein transmembrane import (GO:0044743)	2.96445298
144	gamma-aminobutyric acid transport (GO:0015812)	2.95838818
145	glial cell proliferation (GO:0014009)	2.93512786
146	aromatic amino acid family catabolic process (GO:0009074)	2.93444802
147	fructose metabolic process (GO:0006000)	2.92367953
148	biotin metabolic process (GO:0006768)	2.91004872
149	negative regulation of sodium ion transport (GO:0010766)	2.90370576
150	neuron cell-cell adhesion (GO:0007158)	2.89984134
151	cofactor catabolic process (GO:0051187)	2.89773222
152	bile acid biosynthetic process (GO:0006699)	2.89339666
153	dendritic spine morphogenesis (GO:0060997)	2.89239620
154	regulation of triglyceride biosynthetic process (GO:0010866)	2.87214104
155	activation of protein kinase A activity (GO:0034199)	2.87184718
156	neurotransmitter secretion (GO:0007269)	2.86886241
157	cellular potassium ion homeostasis (GO:0030007)	2.84061865
158	cysteine metabolic process (GO:0006534)	2.83000329
159	amino acid import (GO:0043090)	2.82771720
160	cellular amino acid catabolic process (GO:0009063)	2.81481505
161	alpha-amino acid catabolic process (GO:1901606)	2.80329635
162	regulation of amyloid precursor protein catabolic process (GO:1902991)	2.76569481
163	membrane repolarization (GO:0086009)	2.76030640
164	positive regulation of synaptic transmission, glutamatergic (GO:0051968)	2.75664981
165	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.74974106
166	vocalization behavior (GO:0071625)	2.71992246
167	neuromuscular process controlling balance (GO:0050885)	2.71805936
168	regulation of fatty acid beta-oxidation (GO:0031998)	2.71718288
169	membrane repolarization during action potential (GO:0086011)	2.70706606
170	L-serine metabolic process (GO:0006563)	2.70644344
171	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.70081518
172	amino-acid betaine metabolic process (GO:0006577)	2.67932568
173	homocysteine metabolic process (GO:0050667)	2.67744036
174	negative regulation of protein localization to cell surface (GO:2000009)	2.66670551
175	valine metabolic process (GO:0006573)	2.65337131
176	glutamine family amino acid biosynthetic process (GO:0009084)	2.65053709
177	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.64299602
178	positive regulation of potassium ion transmembrane transport (GO:1901381)	2.62723460
179	proline transport (GO:0015824)	2.62560202
180	axonal fasciculation (GO:0007413)	2.62286338
181	regulation of cholesterol biosynthetic process (GO:0045540)	2.61916316
182	glyoxylate metabolic process (GO:0046487)	2.61487391
183	positive regulation of triglyceride metabolic process (GO:0090208)	2.61187416
184	tryptophan catabolic process (GO:0006569)	2.60899100
185	indole-containing compound catabolic process (GO:0042436)	2.60899100
186	indolalkylamine catabolic process (GO:0046218)	2.60899100
187	hormone catabolic process (GO:0042447)	2.59856574
188	high-density lipoprotein particle remodeling (GO:0034375)	2.55201974
189	alanine transport (GO:0032328)	2.55198419
190	negative regulation of sterol transport (GO:0032372)	2.54466903
191	negative regulation of cholesterol transport (GO:0032375)	2.54466903
192	L-glutamate transport (GO:0015813)	2.54256585
193	acidic amino acid transport (GO:0015800)	2.52666121
194	negative regulation of fibrinolysis (GO:0051918)	2.52604141
195	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.52019888
196	layer formation in cerebral cortex (GO:0021819)	2.51683257
197	neuronal action potential propagation (GO:0019227)	2.50490763
198	serine family amino acid catabolic process (GO:0009071)	2.49111986
199	serine family amino acid biosynthetic process (GO:0009070)	2.48815073
200	cerebellar granule cell differentiation (GO:0021707)	2.47088596

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	5.57696917
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	5.30593504
3	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	5.15741435
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	4.87129151
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.81527361
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	4.44306386
7	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.03126176
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.72233430
9	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.61972406
10	RXR_22158963_ChIP-Seq_LIVER_Mouse	3.51874588
11	EZH2_22144423_ChIP-Seq_EOC_Human	3.48224927
12	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.42510526
13	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.25214348
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.22846880
15	PPARA_22158963_ChIP-Seq_LIVER_Mouse	3.00005793
16	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.94100283
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.91507059
18	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.87870637
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.85692640
20	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.85053135
21	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.81004990
22	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.71192860
23	ELK1_19687146_ChIP-ChIP_HELA_Human	2.68985281
24	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	2.68821714
25	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.67644460
26	DCP1A_22483619_ChIP-Seq_HELA_Human	2.61555222
27	FOXP3_21729870_ChIP-Seq_TREG_Human	2.54527577
28	ERG_21242973_ChIP-ChIP_JURKAT_Human	2.51971522
29	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.50505773
30	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.48964436
31	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.45956201
32	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.44973676
33	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.42314436
34	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.37209830
35	TTF2_22483619_ChIP-Seq_HELA_Human	2.26990643
36	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.25320050
37	* XRN2_22483619_ChIP-Seq_HELA_Human	2.25185863
38	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	2.24960710
39	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.22783771
40	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	2.19969325
41	RARB_27405468_Chip-Seq_BRAIN_Mouse	2.17965692
42	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.16737915
43	GABP_19822575_ChIP-Seq_HepG2_Human	2.13195015
44	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.12794925
45	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.08592298
46	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.05799448
47	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.05001642
48	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.01578913
49	LXR_22292898_ChIP-Seq_THP-1_Human	2.00815083
50	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.99369512
51	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.98703448
52	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.98010556
53	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.97280724
54	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.92527235
55	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.92503275
56	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.90506356
57	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.90506356
58	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.83146247
59	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.81705010
60	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.81473054
61	REST_21632747_ChIP-Seq_MESCs_Mouse	1.81333855
62	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.80464574
63	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.79462202
64	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.78109734
65	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.76598848
66	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.76504596
67	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.75414787
68	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.74086012
69	KDM2B_26808549_Chip-Seq_K562_Human	1.72643148
70	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.70314420
71	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.68128180
72	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.65887891
73	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.65540286
74	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.63242174
75	DROSHA_22980978_ChIP-Seq_HELA_Human	1.62951296
76	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.62906874
77	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.62093337
78	* KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.60275715
79	MYC_18940864_ChIP-ChIP_HL60_Human	1.59845264
80	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.58195204
81	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.58063766
82	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.53439547
83	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.51953093
84	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.48812045
85	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.46892654
86	AR_21572438_ChIP-Seq_LNCaP_Human	1.45261209
87	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.44653236
88	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.42699455
89	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.42147425
90	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.40988225
91	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.40491351
92	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.39296593
93	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.39237525
94	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.39015749
95	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.38917956
96	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.38758820
97	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.37629208
98	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.36002399
99	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.33370549
100	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.33135658
101	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.29919125
102	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.29434125
103	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.28901714
104	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.28543011
105	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.28120931
106	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.27739327
107	KDM5A_27292631_Chip-Seq_BREAST_Human	1.27632832
108	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.27549209
109	CREB1_26743006_Chip-Seq_LNCaP_Human	1.27422713
110	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.26099567
111	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.25262327
112	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.22717849
113	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	1.18595146
114	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.18217985
115	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.17516431
116	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	1.15514746
117	TET1_21490601_ChIP-Seq_MESCs_Mouse	1.14873765
118	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.14605745
119	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.12824616
120	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.12791852
121	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.12487110
122	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.10940020
123	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.10219157
124	KDM2B_26808549_Chip-Seq_DND41_Human	1.09587523
125	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.08135297
126	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.07373892
127	SMC4_20622854_ChIP-Seq_HELA_Human	1.06384036
128	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.06189471
129	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.05504769
130	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.05364748
131	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.04880626
132	CLOCK_20551151_ChIP-Seq_293T_Human	1.04475966
133	ELF5_23300383_ChIP-Seq_T47D_Human	1.03028484
134	CTCF_27219007_Chip-Seq_Bcells_Human	1.02970694
135	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.01463940
136	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.01188016
137	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.99941813
138	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.99470355
139	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.99238478
140	RACK7_27058665_Chip-Seq_MCF-7_Human	0.98195019
141	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.96395543
142	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.96275723
143	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.95782908
144	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.95399885
145	EOMES_21245162_ChIP-Seq_HESCs_Human	0.94684156
146	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.94439237
147	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.94192341
148	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.94031656
149	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.92179172
150	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.91911698
151	TRIM28_21343339_ChIP-Seq_HEK293_Human	0.91587358
152	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.91586286
153	GBX2_23144817_ChIP-Seq_PC3_Human	0.91492260
154	KLF4_19829295_ChIP-Seq_ESCs_Human	0.91378247
155	VDR_22108803_ChIP-Seq_LS180_Human	0.90711629
156	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.89400969
157	AR_19668381_ChIP-Seq_PC3_Human	0.88322821
158	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.87194732
159	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.87094528
160	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.86979294
161	TP63_22573176_ChIP-Seq_HFKS_Human	0.86493816
162	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.86223036
163	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	0.84548658
164	KDM2B_26808549_Chip-Seq_JURKAT_Human	0.84019020
165	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	0.83843934
166	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.83660596
167	POU5F1_16518401_ChIP-PET_MESCs_Mouse	0.83600362
168	ZNF263_19887448_ChIP-Seq_K562_Human	0.83527548
169	* FOXP1_21924763_ChIP-Seq_HESCs_Human	0.83193738
170	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.83162084
171	P68_20966046_ChIP-Seq_HELA_Human	0.82643791
172	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.82053349
173	SA1_27219007_Chip-Seq_Bcells_Human	0.81772123
174	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	0.81749681
175	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.81411657
176	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	0.80553744
177	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.78528668
178	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.77782251
179	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.77692398
180	* TP53_22573176_ChIP-Seq_HFKS_Human	0.77525363
181	AR_20517297_ChIP-Seq_VCAP_Human	0.74044474
182	TFEB_21752829_ChIP-Seq_HELA_Human	0.73112232
183	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.72795556
184	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.72575736
185	ERG_20517297_ChIP-Seq_VCAP_Human	0.72435920
186	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.72186863
187	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.70579412
188	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.69414803
189	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.68454136
190	STAT1_20625510_ChIP-Seq_HELA_Human	0.68104511
191	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.67626628
192	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.67626628
193	EWS_26573619_Chip-Seq_HEK293_Human	0.66322431
194	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.66070475
195	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.65621159
196	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.65257124
197	CIITA_25753668_ChIP-Seq_RAJI_Human	0.64277544

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	5.71594618
2	MP0004859_abnormal_synaptic_plasticity	4.29808346
3	MP0004858_abnormal_nervous_system	3.87369761
4	MP0009379_abnormal_foot_pigmentation	3.52555417
5	MP0005360_urolithiasis	3.45991631
6	MP0005365_abnormal_bile_salt	3.42124359
7	MP0003329_amyloid_beta_deposits	3.35816711
8	MP0003186_abnormal_redox_activity	2.90656791
9	MP0005085_abnormal_gallbladder_physiolo	2.87091450
10	MP0003011_delayed_dark_adaptation	2.70999874
11	MP0003786_premature_aging	2.69722166
12	MP0008058_abnormal_DNA_repair	2.65109487
13	MP0003635_abnormal_synaptic_transmissio	2.50595613
14	MP0003718_maternal_effect	2.48953414
15	MP0004270_analgesia	2.43616935
16	MP0002837_dystrophic_cardiac_calcinosis	2.39973687
17	MP0010329_abnormal_lipoprotein_level	2.38040149
18	MP0006072_abnormal_retinal_apoptosis	2.33836018
19	MP0003806_abnormal_nucleotide_metabolis	2.28424520
20	MP0008875_abnormal_xenobiotic_pharmacok	2.20987040
21	MP0002938_white_spotting	2.13996363
22	MP0009697_abnormal_copulation	2.13872663
23	MP0004957_abnormal_blastocyst_morpholog	2.11591740
24	MP0003705_abnormal_hypodermis_morpholog	2.04805039
25	MP0003693_abnormal_embryo_hatching	2.02780216
26	MP0005083_abnormal_biliary_tract	1.98970821
27	MP0002064_seizures	1.97962612
28	MP0009745_abnormal_behavioral_response	1.97928246
29	MP0000516_abnormal_urinary_system	1.96956599
30	MP0005367_renal/urinary_system_phenotyp	1.96956599
31	MP0000604_amyloidosis	1.88595770
32	MP0008007_abnormal_cellular_replicative	1.86334503
33	MP0010094_abnormal_chromosome_stability	1.86158061
34	MP0001905_abnormal_dopamine_level	1.85135140
35	MP0002063_abnormal_learning/memory/cond	1.83528006
36	MP0002909_abnormal_adrenal_gland	1.82459540
37	MP0005084_abnormal_gallbladder_morpholo	1.75469685
38	MP0001984_abnormal_olfaction	1.74946658
39	MP0001764_abnormal_homeostasis	1.71569313
40	MP0006292_abnormal_olfactory_placode	1.70559221
41	MP0001486_abnormal_startle_reflex	1.69245327
42	MP0009046_muscle_twitch	1.67887300
43	MP0003690_abnormal_glial_cell	1.64018610
44	MP0001666_abnormal_nutrient_absorption	1.62967925
45	MP0010030_abnormal_orbit_morphology	1.62600965
46	MP0002572_abnormal_emotion/affect_behav	1.62480454
47	MP0001756_abnormal_urination	1.61600649
48	MP0002822_catalepsy	1.59594406
49	MP0003252_abnormal_bile_duct	1.57938962
50	MP0005332_abnormal_amino_acid	1.51328483
51	MP0003632_abnormal_nervous_system	1.49731542
52	MP0002118_abnormal_lipid_homeostasis	1.48960242
53	MP0002272_abnormal_nervous_system	1.48858366
54	MP0009780_abnormal_chondrocyte_physiolo	1.48431077
55	MP0003077_abnormal_cell_cycle	1.47526375
56	MP0003111_abnormal_nucleus_morphology	1.45701368
57	MP0004130_abnormal_muscle_cell	1.45518789
58	MP0002277_abnormal_respiratory_mucosa	1.43104602
59	MP0002160_abnormal_reproductive_system	1.42301738
60	MP0010386_abnormal_urinary_bladder	1.40993844
61	MP0002733_abnormal_thermal_nociception	1.37580226
62	MP0009333_abnormal_splenocyte_physiolog	1.36941868
63	MP0009840_abnormal_foam_cell	1.36804381
64	MP0003075_altered_response_to	1.34349478
65	MP0005058_abnormal_lysosome_morphology	1.33086105
66	MP0002734_abnormal_mechanical_nocicepti	1.32543544
67	MP0005636_abnormal_mineral_homeostasis	1.31561414
68	MP0003880_abnormal_central_pattern	1.30642634
69	MP0003137_abnormal_impulse_conducting	1.29958899
70	MP0002876_abnormal_thyroid_physiology	1.29922260
71	MP0001853_heart_inflammation	1.28067074
72	MP0005584_abnormal_enzyme/coenzyme_acti	1.24813090
73	MP0004885_abnormal_endolymph	1.22565413
74	MP0002102_abnormal_ear_morphology	1.20831449
75	MP0003191_abnormal_cellular_cholesterol	1.20414548
76	MP0003631_nervous_system_phenotype	1.19457354
77	MP0002638_abnormal_pupillary_reflex	1.16925496
78	MP0004019_abnormal_vitamin_homeostasis	1.16391528
79	MP0008877_abnormal_DNA_methylation	1.14928156
80	MP0003172_abnormal_lysosome_physiology	1.14887080
81	MP0003633_abnormal_nervous_system	1.14479212
82	MP0003283_abnormal_digestive_organ	1.13839104
83	MP0002736_abnormal_nociception_after	1.12767604
84	MP0005408_hypopigmentation	1.11648895
85	MP0002210_abnormal_sex_determination	1.10311110
86	MP0005410_abnormal_fertilization	1.09033463
87	MP0008961_abnormal_basal_metabolism	1.07968127
88	MP0008872_abnormal_physiological_respon	1.07631795
89	MP0005535_abnormal_body_temperature	1.07468721
90	MP0005646_abnormal_pituitary_gland	1.06886698
91	MP0008569_lethality_at_weaning	1.06666270
92	MP0009643_abnormal_urine_homeostasis	1.05744337
93	MP0010368_abnormal_lymphatic_system	1.05629189
94	MP0000955_abnormal_spinal_cord	1.05307221
95	MP0000751_myopathy	1.05261556
96	MP0000358_abnormal_cell_content/	1.04893265
97	MP0005319_abnormal_enzyme/_coenzyme	1.04717227
98	MP0000747_muscle_weakness	1.03802770
99	MP0008873_increased_physiological_sensi	1.02979418
100	MP0000013_abnormal_adipose_tissue	1.02641472
101	MP0000609_abnormal_liver_physiology	1.02440554
102	MP0002067_abnormal_sensory_capabilities	1.02352575
103	MP0003638_abnormal_response/metabolism_	1.01579119
104	MP0005645_abnormal_hypothalamus_physiol	1.01150143
105	MP0001835_abnormal_antigen_presentation	1.00900305
106	MP0001968_abnormal_touch/_nociception	1.00092946
107	MP0006035_abnormal_mitochondrial_morpho	0.98670915
108	MP0001970_abnormal_pain_threshold	0.98425127
109	MP0003315_abnormal_perineum_morphology	0.97754939
110	MP0001440_abnormal_grooming_behavior	0.97340773
111	MP0004145_abnormal_muscle_electrophysio	0.96855548
112	MP0002090_abnormal_vision	0.96693464
113	MP0004147_increased_porphyrin_level	0.95900205
114	MP0002132_abnormal_respiratory_system	0.95234239
115	MP0008995_early_reproductive_senescence	0.94184336
116	MP0004924_abnormal_behavior	0.93950459
117	MP0005386_behavior/neurological_phenoty	0.93950459
118	MP0005389_reproductive_system_phenotype	0.93696426
119	MP0003868_abnormal_feces_composition	0.92403130
120	MP0000372_irregular_coat_pigmentation	0.91223093
121	MP0002066_abnormal_motor_capabilities/c	0.90422081
122	MP0001944_abnormal_pancreas_morphology	0.90363623
123	MP0003195_calcinosis	0.87668641
124	MP0008874_decreased_physiological_sensi	0.87355496
125	MP0005423_abnormal_somatic_nervous	0.87345405
126	MP0002078_abnormal_glucose_homeostasis	0.87230709
127	MP0006036_abnormal_mitochondrial_physio	0.87212140
128	MP0004215_abnormal_myocardial_fiber	0.85790692
129	MP0002148_abnormal_hypersensitivity_rea	0.84855391
130	MP0002882_abnormal_neuron_morphology	0.82203588
131	MP0003634_abnormal_glial_cell	0.82049154
132	MP0004811_abnormal_neuron_physiology	0.81944438
133	MP0004142_abnormal_muscle_tone	0.81669834
134	MP0002557_abnormal_social/conspecific_i	0.80463363
135	MP0000778_abnormal_nervous_system	0.79983583
136	MP0004043_abnormal_pH_regulation	0.79093683
137	MP0001145_abnormal_male_reproductive	0.79013710
138	MP0003183_abnormal_peptide_metabolism	0.78640568
139	MP0005330_cardiomyopathy	0.78190645
140	MP0005448_abnormal_energy_balance	0.78108669
141	MP0002089_abnormal_postnatal_growth/wei	0.77955183
142	MP0005551_abnormal_eye_electrophysiolog	0.77713891
143	MP0009672_abnormal_birth_weight	0.77350868
144	MP0002971_abnormal_brown_adipose	0.77059379
145	MP0001765_abnormal_ion_homeostasis	0.76432912
146	MP0000653_abnormal_sex_gland	0.75952814
147	MP0002269_muscular_atrophy	0.75478281
148	MP0002653_abnormal_ependyma_morphology	0.75382945
149	MP0002184_abnormal_innervation	0.75289953
150	MP0001929_abnormal_gametogenesis	0.74972362
151	MP0001501_abnormal_sleep_pattern	0.72733660
152	MP0002069_abnormal_eating/drinking_beha	0.72286948
153	MP0002970_abnormal_white_adipose	0.71942054
154	MP0002332_abnormal_exercise_endurance	0.71779061
155	MP0001986_abnormal_taste_sensitivity	0.71278240
156	MP0005452_abnormal_adipose_tissue	0.71254282
157	MP0000538_abnormal_urinary_bladder	0.71186505
158	MP0004087_abnormal_muscle_fiber	0.70849081
159	MP0002229_neurodegeneration	0.70490776
160	MP0008775_abnormal_heart_ventricle	0.70424244
161	MP0002693_abnormal_pancreas_physiology	0.69494455
162	MP0001664_abnormal_digestion	0.69367825
163	MP0005501_abnormal_skin_physiology	0.69086543
164	MP0003879_abnormal_hair_cell	0.68918185
165	MP0001873_stomach_inflammation	0.68511460
166	MP0005379_endocrine/exocrine_gland_phen	0.68386234
167	MP0001542_abnormal_bone_strength	0.68014517
168	MP0000313_abnormal_cell_death	0.67504531
169	MP0002295_abnormal_pulmonary_circulatio	0.66842425
170	MP0005165_increased_susceptibility_to	0.66784783
171	MP0001881_abnormal_mammary_gland	0.66399344
172	MP0001529_abnormal_vocalization	0.65627893
173	MP0001879_abnormal_lymphatic_vessel	0.65374884
174	MP0005670_abnormal_white_adipose	0.64945777
175	MP0005253_abnormal_eye_physiology	0.62747395
176	MP0005075_abnormal_melanosome_morpholog	0.62741909
177	MP0002163_abnormal_gland_morphology	0.62526320

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.80648865
2	Mitochondrial inheritance (HP:0001427)	5.52714268
3	Increased hepatocellular lipid droplets (HP:0006565)	5.24225034
4	Hepatocellular necrosis (HP:0001404)	5.20019419
5	Abnormal mitochondria in muscle tissue (HP:0008316)	5.18313886
6	Increased CSF lactate (HP:0002490)	5.00517367
7	Hepatic necrosis (HP:0002605)	4.94879283
8	3-Methylglutaconic aciduria (HP:0003535)	4.92874880
9	Progressive macrocephaly (HP:0004481)	4.85385553
10	Acute encephalopathy (HP:0006846)	4.80764338
11	Renal Fanconi syndrome (HP:0001994)	4.76409083
12	Lipid accumulation in hepatocytes (HP:0006561)	4.70185614
13	Decreased activity of mitochondrial respiratory chain (HP:0008972)	4.58756975
14	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	4.58756975
15	Congenital, generalized hypertrichosis (HP:0004540)	4.42399263
16	Deep venous thrombosis (HP:0002625)	4.15287313
17	Abnormality of the lower motor neuron (HP:0002366)	3.99875532
18	Exertional dyspnea (HP:0002875)	3.98258919
19	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.92366218
20	Abnormal number of erythroid precursors (HP:0012131)	3.83535346
21	Macrocytic anemia (HP:0001972)	3.83258971
22	Methylmalonic acidemia (HP:0002912)	3.81550217
23	Abnormality of cells of the erythroid lineage (HP:0012130)	3.73645090
24	Myokymia (HP:0002411)	3.66611495
25	Xanthomatosis (HP:0000991)	3.63682134
26	Hyperglycinuria (HP:0003108)	3.60756369
27	Cerebral edema (HP:0002181)	3.59853508
28	Increased intramyocellular lipid droplets (HP:0012240)	3.52429551
29	Increased serum lactate (HP:0002151)	3.46329130
30	Type I transferrin isoform profile (HP:0003642)	3.41111983
31	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	3.33506216
32	Postural instability (HP:0002172)	3.30897633
33	Hyperventilation (HP:0002883)	3.30238919
34	Ketoacidosis (HP:0001993)	3.29765906
35	Lactic acidosis (HP:0003128)	3.29643626
36	Intrahepatic cholestasis (HP:0001406)	3.27272222
37	Cerebral inclusion bodies (HP:0100314)	3.17964040
38	Hyperlipoproteinemia (HP:0010980)	3.17805795
39	Abnormality of methionine metabolism (HP:0010901)	3.17031555
40	Hemiplegia (HP:0002301)	3.16565805
41	Abnormality of glycine metabolism (HP:0010895)	3.16412366
42	Abnormality of serine family amino acid metabolism (HP:0010894)	3.16412366
43	Respiratory failure (HP:0002878)	3.15570326
44	Methylmalonic aciduria (HP:0012120)	3.14555581
45	Neurofibrillary tangles (HP:0002185)	3.13270843
46	Ketosis (HP:0001946)	3.12890416
47	Abnormality of renal resorption (HP:0011038)	3.12673823
48	Supranuclear gaze palsy (HP:0000605)	3.10384532
49	Visual hallucinations (HP:0002367)	3.09928384
50	Increased muscle lipid content (HP:0009058)	3.09758766
51	Exercise intolerance (HP:0003546)	3.04834958
52	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.99485951
53	Dysdiadochokinesis (HP:0002075)	2.98112441
54	Generalized aminoaciduria (HP:0002909)	2.90191693
55	Respiratory difficulties (HP:0002880)	2.89771451
56	Abnormality of urine glucose concentration (HP:0011016)	2.84282152
57	Glycosuria (HP:0003076)	2.84282152
58	Hyperammonemia (HP:0001987)	2.80136358
59	Testicular atrophy (HP:0000029)	2.79724838
60	Focal motor seizures (HP:0011153)	2.77330494
61	Abnormal protein glycosylation (HP:0012346)	2.75264471
62	Abnormal glycosylation (HP:0012345)	2.75264471
63	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.75264471
64	Abnormal protein N-linked glycosylation (HP:0012347)	2.75264471
65	Abnormality of alanine metabolism (HP:0010916)	2.73033741
66	Hyperalaninemia (HP:0003348)	2.73033741
67	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.73033741
68	Gout (HP:0001997)	2.72594401
69	Hemiparesis (HP:0001269)	2.70566732
70	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.69279442
71	Intention tremor (HP:0002080)	2.68931384
72	Aplasia involving bones of the extremities (HP:0009825)	2.67639754
73	Aplasia involving bones of the upper limbs (HP:0009823)	2.67639754
74	Aplasia of the phalanges of the hand (HP:0009802)	2.67639754
75	Lethargy (HP:0001254)	2.66651741
76	Aplastic anemia (HP:0001915)	2.63278424
77	Delayed CNS myelination (HP:0002188)	2.62128232
78	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.59078586
79	Optic disc pallor (HP:0000543)	2.57842451
80	Hypobetalipoproteinemia (HP:0003563)	2.57346096
81	Global brain atrophy (HP:0002283)	2.56600025
82	Leukodystrophy (HP:0002415)	2.56532898
83	Abnormality of the Achilles tendon (HP:0005109)	2.56346841
84	Cholecystitis (HP:0001082)	2.54393067
85	Abnormal gallbladder physiology (HP:0012438)	2.54393067
86	Status epilepticus (HP:0002133)	2.50585705
87	Focal seizures (HP:0007359)	2.50539427
88	Reduced antithrombin III activity (HP:0001976)	2.49621328
89	Myoglobinuria (HP:0002913)	2.48207462
90	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.47050963
91	Dicarboxylic aciduria (HP:0003215)	2.46991985
92	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.46991985
93	Skin nodule (HP:0200036)	2.45448622
94	Action tremor (HP:0002345)	2.45446503
95	Generalized tonic-clonic seizures (HP:0002069)	2.44579780
96	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.43796059
97	Pseudobulbar signs (HP:0002200)	2.41935553
98	Pheochromocytoma (HP:0002666)	2.40497711
99	Tetraplegia (HP:0002445)	2.40182476
100	Homocystinuria (HP:0002156)	2.37145462
101	Abnormality of homocysteine metabolism (HP:0010919)	2.37145462
102	Pallor (HP:0000980)	2.36814249
103	Resting tremor (HP:0002322)	2.36721877
104	Prolonged partial thromboplastin time (HP:0003645)	2.33939682
105	Horizontal nystagmus (HP:0000666)	2.33796972
106	Megaloblastic anemia (HP:0001889)	2.32883765
107	Abnormality of vitamin B metabolism (HP:0004340)	2.32233892
108	Impaired smooth pursuit (HP:0007772)	2.30783833
109	Dysmetric saccades (HP:0000641)	2.29288176
110	Achilles tendon contracture (HP:0001771)	2.27172086
111	Hyperglycinemia (HP:0002154)	2.26780671
112	Abnormality of ocular smooth pursuit (HP:0000617)	2.26709782
113	Reticulocytopenia (HP:0001896)	2.26013368
114	Hypothermia (HP:0002045)	2.24998620
115	Abnormality of placental membranes (HP:0011409)	2.24220063
116	Amniotic constriction ring (HP:0009775)	2.24220063
117	Truncal ataxia (HP:0002078)	2.24118302
118	Back pain (HP:0003418)	2.24113922
119	Epileptic encephalopathy (HP:0200134)	2.23751244
120	Exercise-induced myalgia (HP:0003738)	2.22416024
121	CNS demyelination (HP:0007305)	2.22041549
122	Complement deficiency (HP:0004431)	2.22029410
123	Depression (HP:0000716)	2.20641984
124	Ragged-red muscle fibers (HP:0003200)	2.19682436
125	Bilateral microphthalmos (HP:0007633)	2.19633644
126	Oral leukoplakia (HP:0002745)	2.19333161
127	Hyperphosphaturia (HP:0003109)	2.18110833
128	Abnormality of serum amino acid levels (HP:0003112)	2.17898689
129	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.14245909
130	Bradykinesia (HP:0002067)	2.13402687
131	Degeneration of anterior horn cells (HP:0002398)	2.12954941
132	Abnormality of the anterior horn cell (HP:0006802)	2.12954941
133	Neuroendocrine neoplasm (HP:0100634)	2.12921398
134	Turricephaly (HP:0000262)	2.12812410
135	Increased serum pyruvate (HP:0003542)	2.11793827
136	Hepatoblastoma (HP:0002884)	2.11228314
137	Renal tubular dysfunction (HP:0000124)	2.10879872
138	Neonatal onset (HP:0003623)	2.10586347
139	Sensorimotor neuropathy (HP:0007141)	2.09867731
140	Hypochromic microcytic anemia (HP:0004840)	2.08448933
141	Epidermoid cyst (HP:0200040)	2.07784085
142	Abnormal eating behavior (HP:0100738)	2.06861948
143	Abnormality of the intrinsic pathway (HP:0010989)	2.06849518
144	Abnormality of fatty-acid metabolism (HP:0004359)	2.06774318
145	Hypoglycemic seizures (HP:0002173)	2.06613189
146	Abnormal social behavior (HP:0012433)	2.05793898
147	Impaired social interactions (HP:0000735)	2.05793898
148	Generalized hypotonia (HP:0001290)	2.04419615
149	Cholelithiasis (HP:0001081)	2.00776073
150	Dysmetria (HP:0001310)	1.99007025
151	Abnormal urine phosphate concentration (HP:0012599)	1.98414219
152	Distal upper limb amyotrophy (HP:0007149)	1.97778537
153	Upper limb amyotrophy (HP:0009129)	1.97778537
154	Large for gestational age (HP:0001520)	1.97538363
155	Hypolipoproteinemia (HP:0010981)	1.96531244
156	EMG: neuropathic changes (HP:0003445)	1.95356657
157	Spastic diplegia (HP:0001264)	1.93516586
158	X-linked dominant inheritance (HP:0001423)	1.93491710
159	Generalized myoclonic seizures (HP:0002123)	1.92734839
160	Metabolic acidosis (HP:0001942)	1.91895857
161	Opisthotonus (HP:0002179)	1.90704603
162	Abnormal gallbladder morphology (HP:0012437)	1.90568060
163	Emotional lability (HP:0000712)	1.85837889
164	Hypoalphalipoproteinemia (HP:0003233)	1.85491509
165	Sparse eyelashes (HP:0000653)	1.85347168
166	Cleft eyelid (HP:0000625)	1.84946047
167	Hyperinsulinemic hypoglycemia (HP:0000825)	1.84524766
168	Rigidity (HP:0002063)	1.84388273
169	Rapidly progressive (HP:0003678)	1.84296834
170	Woolly hair (HP:0002224)	1.83685311
171	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.83053791
172	Clumsiness (HP:0002312)	1.83013429
173	Progressive cerebellar ataxia (HP:0002073)	1.82970746
174	Neuronal loss in central nervous system (HP:0002529)	1.82687266
175	Hypopigmentation of the fundus (HP:0007894)	1.82122663
176	Renal cortical cysts (HP:0000803)	1.81193762
177	Abnormality of the periventricular white matter (HP:0002518)	1.81107071
178	Aplasia/hypoplasia of the uterus (HP:0008684)	1.80814621
179	Hypoglycemic coma (HP:0001325)	1.80753818
180	Spastic tetraparesis (HP:0001285)	1.79028788
181	Molar tooth sign on MRI (HP:0002419)	1.78211052
182	Abnormality of midbrain morphology (HP:0002418)	1.78211052
183	Abnormality of glutamine family amino acid metabolism (HP:0010902)	1.77947782
184	Morphological abnormality of the pyramidal tract (HP:0002062)	1.77649974
185	Papilledema (HP:0001085)	1.77474091
186	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.77458555
187	Amyloidosis (HP:0011034)	1.76491630
188	Blindness (HP:0000618)	1.76444320
189	Neoplasm of the heart (HP:0100544)	1.76229772
190	Cerebral hypomyelination (HP:0006808)	1.74971356
191	Palpitations (HP:0001962)	1.74932973
192	Reticulocytosis (HP:0001923)	1.73826484
193	Pancreatic cysts (HP:0001737)	1.72201656
194	Abnormality of glycolysis (HP:0004366)	1.71975330
195	Congenital ichthyosiform erythroderma (HP:0007431)	1.71772130
196	Vomiting (HP:0002013)	1.71506988
197	Abnormal spermatogenesis (HP:0008669)	1.67737277
198	Hypoplasia of the pons (HP:0012110)	1.64330077

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	4.64319360
2	TLK1	4.39565872
3	TRIB3	4.33775112
4	STK16	4.22600898
5	MST4	4.09875061
6	BUB1	3.31187213
7	NME1	2.94265110
8	MAP3K4	2.86117875
9	MAP3K12	2.81207558
10	SRPK1	2.75443053
11	SIK1	2.72724394
12	EIF2AK1	2.63447362
13	NTRK1	2.63094133
14	EPHA4	2.59197057
15	MAP2K4	2.54797388
16	NME2	2.52224608
17	MAP3K9	2.37821368
18	GRK6	2.27359103
19	ERN1	2.23051093
20	PKN2	2.16241962
21	GRK5	2.06887874
22	PDK2	2.05147797
23	NTRK2	2.00883772
24	VRK1	1.98122546
25	PHKG2	1.96925185
26	PHKG1	1.96925185
27	PRKD3	1.87395116
28	CDK12	1.81872673
29	MAP2K6	1.81318685
30	NTRK3	1.79761188
31	EPHA2	1.77440872
32	MAP2K7	1.77000797
33	MYLK	1.73459226
34	LMTK2	1.72853118
35	TYRO3	1.72583305
36	MAP3K7	1.66258320
37	TESK1	1.64824724
38	RIPK1	1.61285803
39	KSR2	1.56675072
40	NUAK1	1.56470438
41	ZAK	1.53869810
42	TIE1	1.48583665
43	MAP4K2	1.47347077
44	EIF2AK3	1.46315037
45	PAK6	1.45231541
46	CAMKK1	1.42680681
47	ICK	1.40292946
48	BCKDK	1.40027545
49	MAP3K10	1.37216592
50	DMPK	1.36410016
51	PAK4	1.34530966
52	DAPK2	1.29028058
53	WNK4	1.26888675
54	BMPR1B	1.24238753
55	MINK1	1.22844879
56	INSRR	1.22491860
57	LIMK1	1.21948024
58	ADRBK2	1.21531279
59	PLK4	1.20390284
60	RET	1.18298314
61	GRK1	1.17844701
62	PDGFRA	1.17684031
63	PDK3	1.13417763
64	PDK4	1.13417763
65	TSSK6	1.13255767
66	CDK8	1.09752503
67	ILK	1.09195209
68	OXSR1	1.08835770
69	PLK3	1.06983926
70	WNK1	1.05307037
71	TESK2	1.01348572
72	KSR1	1.00492199
73	STK38	1.00222855
74	MAPK15	0.99047560
75	SIK2	0.97888229
76	DDR2	0.96876563
77	ABL2	0.95759873
78	PTK6	0.95158898
79	CASK	0.94685438
80	NEK1	0.94577545
81	MAP3K13	0.94155735
82	TAOK1	0.93217701
83	LATS2	0.93045940
84	PAK3	0.91389707
85	CCNB1	0.91192167
86	CAMK1G	0.90956462
87	MARK1	0.87532919
88	MARK2	0.86618843
89	PLK1	0.84636051
90	WNK3	0.83606822
91	CDC42BPA	0.83494682
92	PRKCG	0.83068739
93	BMX	0.82961404
94	FLT3	0.82689877
95	PIM2	0.82380128
96	AURKB	0.82200891
97	CDK5	0.81684758
98	PRKCH	0.81166251
99	ALK	0.81005163
100	MAPK7	0.80828450
101	MAPKAPK3	0.80618382
102	IKBKB	0.80272289
103	MST1R	0.79538683
104	PBK	0.79421889
105	CAMK1D	0.74943684
106	CAMK4	0.74637805
107	CDC7	0.74604137
108	PRKCI	0.74261264
109	ARAF	0.73997590
110	STK11	0.72001333
111	MATK	0.71958858
112	RPS6KB2	0.71349025
113	MAPK12	0.69024657
114	CSNK1G3	0.68224616
115	TAF1	0.67707258
116	FRK	0.67487952
117	CSNK2A2	0.67052901
118	BRSK1	0.66888997
119	KDR	0.65734186
120	UHMK1	0.65494524
121	CDK19	0.64519543
122	EIF2AK2	0.64181111
123	PDK1	0.62916750
124	SGK3	0.62503783
125	MAPKAPK5	0.61905493
126	MAP3K6	0.61291674
127	CSNK2A1	0.60877294
128	CSNK1G1	0.60851290
129	PASK	0.60174146
130	SGK494	0.59705165
131	SGK223	0.59705165
132	RAF1	0.59242156
133	MAPK13	0.58904460
134	DAPK1	0.58429618
135	STK39	0.57478572
136	MUSK	0.57458023
137	RPS6KA2	0.56477112
138	FGR	0.55692624
139	EEF2K	0.54691519
140	DAPK3	0.54493971
141	BMPR2	0.54102739
142	CAMKK2	0.53043119
143	CDK15	0.51774100
144	CSF1R	0.51686326
145	CAMK2B	0.50437402
146	CAMK2G	0.48540406
147	CDK18	0.47549572
148	PRKAA1	0.46322187
149	PRKD2	0.46163024
150	PDPK1	0.46047388
151	MAPK4	0.45435799
152	LRRK2	0.43993100
153	CDK7	0.43610830
154	RPS6KA3	0.43599122
155	SGK2	0.43588647
156	PTK2	0.43507527
157	RPS6KA5	0.43316416
158	PTK2B	0.43269696
159	CDK11A	0.42430722
160	CDK14	0.42382836
161	TAOK3	0.40364637
162	CSNK1G2	0.39318909
163	PNCK	0.38760295
164	PRKACG	0.38689052
165	SGK1	0.38429917
166	TRIM28	0.37855109
167	ATR	0.37773511
168	CAMK2D	0.37044312
169	TTK	0.36860942
170	TNK2	0.35544840
171	ADRBK1	0.34741274
172	MET	0.33975081
173	TEC	0.33567927
174	CSNK1A1L	0.33181689
175	CDK3	0.31837022
176	CLK1	0.31633059
177	AURKA	0.30688189
178	MAP2K3	0.30345589
179	CSNK1A1	0.30305006
180	DYRK2	0.27196656
181	CSNK1E	0.26031208
182	SCYL2	0.25685009
183	STK38L	0.25052922
184	PRKG1	0.23513023
185	FGFR1	0.21544812
186	TXK	0.21121851
187	NEK2	0.20801649

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.12849350
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.66327214
3	Proteasome_Homo sapiens_hsa03050	4.13052980
4	Parkinsons disease_Homo sapiens_hsa05012	3.71903026
5	Nitrogen metabolism_Homo sapiens_hsa00910	3.59881853
6	Protein export_Homo sapiens_hsa03060	3.42691677
7	RNA polymerase_Homo sapiens_hsa03020	3.04315731
8	Huntingtons disease_Homo sapiens_hsa05016	2.61816580
9	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.56081973
10	Alzheimers disease_Homo sapiens_hsa05010	2.48850358
11	Homologous recombination_Homo sapiens_hsa03440	2.48192755
12	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.43534344
13	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.42405007
14	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.36638900
15	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.32893506
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.31456035
17	Mismatch repair_Homo sapiens_hsa03430	2.29424277
18	Fatty acid degradation_Homo sapiens_hsa00071	2.17055827
19	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	2.12824332
20	Fatty acid metabolism_Homo sapiens_hsa01212	2.09378066
21	Arginine biosynthesis_Homo sapiens_hsa00220	2.08837314
22	Nucleotide excision repair_Homo sapiens_hsa03420	2.08654235
23	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.06776054
24	DNA replication_Homo sapiens_hsa03030	2.05868704
25	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.97225519
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.94658318
27	Propanoate metabolism_Homo sapiens_hsa00640	1.78476382
28	Basal transcription factors_Homo sapiens_hsa03022	1.72380953
29	Bile secretion_Homo sapiens_hsa04976	1.71471769
30	Spliceosome_Homo sapiens_hsa03040	1.68785431
31	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.66981494
32	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.65445220
33	Tryptophan metabolism_Homo sapiens_hsa00380	1.64372524
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.62420604
35	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.60289868
36	PPAR signaling pathway_Homo sapiens_hsa03320	1.58216520
37	Cardiac muscle contraction_Homo sapiens_hsa04260	1.56205365
38	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.54959990
39	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.54881213
40	One carbon pool by folate_Homo sapiens_hsa00670	1.54715147
41	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.54079886
42	RNA degradation_Homo sapiens_hsa03018	1.52681454
43	Sulfur relay system_Homo sapiens_hsa04122	1.51209921
44	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.51114701
45	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.49948641
46	Glutamatergic synapse_Homo sapiens_hsa04724	1.47194650
47	Base excision repair_Homo sapiens_hsa03410	1.45288853
48	Butanoate metabolism_Homo sapiens_hsa00650	1.45067158
49	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.44255821
50	Carbon metabolism_Homo sapiens_hsa01200	1.43394422
51	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.40665681
52	Collecting duct acid secretion_Homo sapiens_hsa04966	1.40514239
53	Glycerolipid metabolism_Homo sapiens_hsa00561	1.39400569
54	Complement and coagulation cascades_Homo sapiens_hsa04610	1.33279321
55	GABAergic synapse_Homo sapiens_hsa04727	1.31979231
56	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.30535465
57	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.29841129
58	Pyruvate metabolism_Homo sapiens_hsa00620	1.27822365
59	Asthma_Homo sapiens_hsa05310	1.23786579
60	Olfactory transduction_Homo sapiens_hsa04740	1.21471445
61	Folate biosynthesis_Homo sapiens_hsa00790	1.21009397
62	RNA transport_Homo sapiens_hsa03013	1.19663551
63	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.19527808
64	Gastric acid secretion_Homo sapiens_hsa04971	1.17628382
65	Fanconi anemia pathway_Homo sapiens_hsa03460	1.15752129
66	Nicotine addiction_Homo sapiens_hsa05033	1.13319277
67	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.12733316
68	Purine metabolism_Homo sapiens_hsa00230	1.07640673
69	Circadian entrainment_Homo sapiens_hsa04713	1.07042926
70	Salivary secretion_Homo sapiens_hsa04970	1.06908464
71	Peroxisome_Homo sapiens_hsa04146	1.04268186
72	Glutathione metabolism_Homo sapiens_hsa00480	0.99177701
73	Regulation of autophagy_Homo sapiens_hsa04140	0.96097430
74	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.95910356
75	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.95063054
76	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.94209063
77	Fatty acid elongation_Homo sapiens_hsa00062	0.92262103
78	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.89060955
79	Long-term potentiation_Homo sapiens_hsa04720	0.88503820
80	Dopaminergic synapse_Homo sapiens_hsa04728	0.88338450
81	Insulin secretion_Homo sapiens_hsa04911	0.86105238
82	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.85141364
83	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.84445198
84	Amphetamine addiction_Homo sapiens_hsa05031	0.83937728
85	Morphine addiction_Homo sapiens_hsa05032	0.83933894
86	Non-homologous end-joining_Homo sapiens_hsa03450	0.82388692
87	Cocaine addiction_Homo sapiens_hsa05030	0.81252346
88	Metabolic pathways_Homo sapiens_hsa01100	0.80653325
89	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.80281347
90	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.79362893
91	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.79199690
92	Glucagon signaling pathway_Homo sapiens_hsa04922	0.79000456
93	beta-Alanine metabolism_Homo sapiens_hsa00410	0.78040577
94	Long-term depression_Homo sapiens_hsa04730	0.77351815
95	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.76227863
96	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.75075076
97	Sulfur metabolism_Homo sapiens_hsa00920	0.74860139
98	Pentose phosphate pathway_Homo sapiens_hsa00030	0.74705780
99	Gap junction_Homo sapiens_hsa04540	0.74112320
100	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.71952394
101	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.69198438
102	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.67423915
103	Allograft rejection_Homo sapiens_hsa05330	0.66957804
104	Type I diabetes mellitus_Homo sapiens_hsa04940	0.66834199
105	Chemical carcinogenesis_Homo sapiens_hsa05204	0.65616844
106	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.64888432
107	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.64346985
108	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.64196545
109	Fat digestion and absorption_Homo sapiens_hsa04975	0.64175883
110	Insulin resistance_Homo sapiens_hsa04931	0.62208066
111	Rheumatoid arthritis_Homo sapiens_hsa05323	0.60519611
112	GnRH signaling pathway_Homo sapiens_hsa04912	0.60397403
113	Retinol metabolism_Homo sapiens_hsa00830	0.60337150
114	Cholinergic synapse_Homo sapiens_hsa04725	0.59796596
115	ABC transporters_Homo sapiens_hsa02010	0.59058480
116	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.58486744
117	Type II diabetes mellitus_Homo sapiens_hsa04930	0.57538332
118	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.56856889
119	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.56455374
120	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.56114719
121	Insulin signaling pathway_Homo sapiens_hsa04910	0.56103388
122	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.55794710
123	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.55745613
124	Linoleic acid metabolism_Homo sapiens_hsa00591	0.55575079
125	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.54892575
126	cAMP signaling pathway_Homo sapiens_hsa04024	0.54734037
127	Galactose metabolism_Homo sapiens_hsa00052	0.54183997
128	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.53831064
129	Arginine and proline metabolism_Homo sapiens_hsa00330	0.53178437
130	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.52817931
131	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.52625414
132	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.50765377
133	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.50494804
134	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.50019049
135	Tyrosine metabolism_Homo sapiens_hsa00350	0.48803703
136	Estrogen signaling pathway_Homo sapiens_hsa04915	0.48758857
137	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.48687877
138	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.48015650
139	Calcium signaling pathway_Homo sapiens_hsa04020	0.46921531
140	Mineral absorption_Homo sapiens_hsa04978	0.46825659
141	Pancreatic secretion_Homo sapiens_hsa04972	0.46696146
142	Taste transduction_Homo sapiens_hsa04742	0.46677203
143	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.45534894
144	mTOR signaling pathway_Homo sapiens_hsa04150	0.45376384
145	Selenocompound metabolism_Homo sapiens_hsa00450	0.44175338
146	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.44068391
147	Renin secretion_Homo sapiens_hsa04924	0.43035907
148	Caffeine metabolism_Homo sapiens_hsa00232	0.43008291
149	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.42749036
150	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.42686596
151	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.41781009
152	Phenylalanine metabolism_Homo sapiens_hsa00360	0.41076531
153	AMPK signaling pathway_Homo sapiens_hsa04152	0.40438329
154	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.40148233
155	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.37618254
156	Graft-versus-host disease_Homo sapiens_hsa05332	0.37427917
157	Vibrio cholerae infection_Homo sapiens_hsa05110	0.33300064
158	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.33132116
159	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.31016964
160	Other glycan degradation_Homo sapiens_hsa00511	0.29441329
161	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.26904515
162	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.22004894
163	Ether lipid metabolism_Homo sapiens_hsa00565	0.21358287
164	mRNA surveillance pathway_Homo sapiens_hsa03015	0.19973872
165	p53 signaling pathway_Homo sapiens_hsa04115	0.19172413
166	Cell cycle_Homo sapiens_hsa04110	0.17805705
167	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.16964887
168	Steroid biosynthesis_Homo sapiens_hsa00100	0.16052269

PRICKLE4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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