PRIMA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene functions to organize acetylcholinesterase (AChE) into tetramers, and to anchor AChE at neural cell membranes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1myelination (GO:0042552)6.51515453
2ensheathment of neurons (GO:0007272)6.49738466
3axon ensheathment (GO:0008366)6.49738466
4fatty acid elongation (GO:0030497)6.21392807
5embryonic retina morphogenesis in camera-type eye (GO:0060059)4.86183903
6oligodendrocyte differentiation (GO:0048709)4.80894097
7negative regulation of neurotransmitter secretion (GO:0046929)4.72443555
8long-chain fatty acid biosynthetic process (GO:0042759)4.68027767
9substantia nigra development (GO:0021762)4.53458663
10myelin maintenance (GO:0043217)4.49650604
11cholesterol biosynthetic process (GO:0006695)4.46914141
12transmission of nerve impulse (GO:0019226)4.42789984
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.37922873
14creatine metabolic process (GO:0006600)4.36439973
15membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.31653892
16negative regulation of neurotransmitter transport (GO:0051589)4.29853976
17sodium ion export (GO:0071436)4.18613524
18glycerophospholipid catabolic process (GO:0046475)4.04996632
19regulation of collateral sprouting (GO:0048670)4.02851850
20negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.97888161
21peptidyl-tyrosine autophosphorylation (GO:0038083)3.97464219
22cellular potassium ion homeostasis (GO:0030007)3.93121151
23regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.90086177
24sterol biosynthetic process (GO:0016126)3.85620367
25locomotory exploration behavior (GO:0035641)3.80528204
26cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.80018023
27establishment of mitochondrion localization (GO:0051654)3.79024518
28astrocyte development (GO:0014002)3.78375283
29presynaptic membrane organization (GO:0097090)3.73086301
30presynaptic membrane assembly (GO:0097105)3.70703431
31adhesion of symbiont to host cell (GO:0044650)3.70203823
32virion attachment to host cell (GO:0019062)3.70203823
33cerebellar granule cell differentiation (GO:0021707)3.68477998
34neuronal ion channel clustering (GO:0045161)3.67463897
35adult walking behavior (GO:0007628)3.66064285
36negative regulation of protein localization to cell surface (GO:2000009)3.65981160
37peripheral nervous system axon ensheathment (GO:0032292)3.61273340
38myelination in peripheral nervous system (GO:0022011)3.61273340
39ionotropic glutamate receptor signaling pathway (GO:0035235)3.57382040
40negative regulation of axonogenesis (GO:0050771)3.56204770
41response to redox state (GO:0051775)3.55755001
42positive regulation of synapse maturation (GO:0090129)3.53546655
43postsynaptic membrane organization (GO:0001941)3.51180428
44cell communication by electrical coupling (GO:0010644)3.47443402
45asymmetric protein localization (GO:0008105)3.46612692
46L-amino acid import (GO:0043092)3.45886545
47neuron cell-cell adhesion (GO:0007158)3.42527417
48neurotransmitter-gated ion channel clustering (GO:0072578)3.37958310
49cerebral cortex radially oriented cell migration (GO:0021799)3.33377876
50regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.32963625
51photoreceptor cell differentiation (GO:0046530)3.32628059
52eye photoreceptor cell differentiation (GO:0001754)3.32628059
53long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.30613057
54cellular sodium ion homeostasis (GO:0006883)3.29462105
55dendritic spine morphogenesis (GO:0060997)3.28345695
56neuromuscular process controlling balance (GO:0050885)3.28263343
57neuronal action potential propagation (GO:0019227)3.28033053
58cerebellar Purkinje cell differentiation (GO:0021702)3.27713052
59apical protein localization (GO:0045176)3.26327042
60negative regulation of axon extension (GO:0030517)3.26157439
61glutamate secretion (GO:0014047)3.25137546
62regulation of synaptic vesicle exocytosis (GO:2000300)3.24039416
63positive regulation of action potential (GO:0045760)3.23860293
64vocalization behavior (GO:0071625)3.23706283
65cell communication involved in cardiac conduction (GO:0086065)3.23327464
66potassium ion homeostasis (GO:0055075)3.22278760
67limb bud formation (GO:0060174)3.18493916
68neurotransmitter secretion (GO:0007269)3.17995490
69isoprenoid biosynthetic process (GO:0008299)3.17889635
70positive regulation of oligodendrocyte differentiation (GO:0048714)3.13139376
71regulation of neuronal synaptic plasticity (GO:0048168)3.12784085
72cellular response to epinephrine stimulus (GO:0071872)3.11530844
73import into cell (GO:0098657)3.11053002
74cell migration in hindbrain (GO:0021535)3.08701684
75protein palmitoylation (GO:0018345)3.07788556
76membrane hyperpolarization (GO:0060081)3.06765061
77exploration behavior (GO:0035640)3.04944719
78synaptic vesicle maturation (GO:0016188)3.04778795
79membrane tubulation (GO:0097320)3.03985856
80neural nucleus development (GO:0048857)3.03966038
81peripheral nervous system development (GO:0007422)3.03328789
82regulation of catecholamine metabolic process (GO:0042069)3.02487103
83regulation of dopamine metabolic process (GO:0042053)3.02487103
84long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.00545257
85cell differentiation in hindbrain (GO:0021533)2.93072474
86regulation of voltage-gated calcium channel activity (GO:1901385)2.91727299
87regulation of synapse maturation (GO:0090128)2.90058953
88positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.89393649
89layer formation in cerebral cortex (GO:0021819)2.89311717
90fatty-acyl-CoA biosynthetic process (GO:0046949)2.87810056
91enteric nervous system development (GO:0048484)2.86190850
92actin filament depolymerization (GO:0030042)2.85631741
93thalamus development (GO:0021794)2.83467395
94positive regulation of synaptic transmission, GABAergic (GO:0032230)2.81037764
95regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.78889435
96amyloid precursor protein metabolic process (GO:0042982)2.78821785
97cellular response to catecholamine stimulus (GO:0071870)2.78598783
98cellular response to monoamine stimulus (GO:0071868)2.78598783
99adhesion of symbiont to host (GO:0044406)2.76251365
100synaptic transmission, dopaminergic (GO:0001963)2.75395384
101potassium ion import (GO:0010107)2.75372477
102protein localization to synapse (GO:0035418)2.75268188
103negative regulation of dendrite morphogenesis (GO:0050774)2.72999877
104peptidyl-cysteine modification (GO:0018198)2.72501960
105glial cell development (GO:0021782)2.72237016
106regulation of dendritic spine morphogenesis (GO:0061001)2.72187692
107response to epinephrine (GO:0071871)2.71988904
108synaptic transmission, glutamatergic (GO:0035249)2.70998839
109fatty-acyl-CoA metabolic process (GO:0035337)2.70581753
110synaptic vesicle exocytosis (GO:0016079)2.69709943
111positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.68556093
112regulation of synaptic vesicle transport (GO:1902803)2.68005111
113response to lipoprotein particle (GO:0055094)2.67514726
114nerve growth factor signaling pathway (GO:0038180)2.65590011
115glutamate receptor signaling pathway (GO:0007215)2.65547890
116cyclic nucleotide catabolic process (GO:0009214)2.65141629
117neurotransmitter transport (GO:0006836)2.64672434
118regulation of long-term neuronal synaptic plasticity (GO:0048169)2.62999479
119regulation of short-term neuronal synaptic plasticity (GO:0048172)2.62802596
120dendrite morphogenesis (GO:0048813)2.61726703
121mating behavior (GO:0007617)2.61375966
122regulation of glutamate receptor signaling pathway (GO:1900449)2.60587218
123innervation (GO:0060384)2.60006321
124mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.59643079
125membrane assembly (GO:0071709)2.59255629
126neuron projection regeneration (GO:0031102)2.59190510
127gamma-aminobutyric acid transport (GO:0015812)2.58200232
128activation of protein kinase A activity (GO:0034199)2.57625545
129neurofilament cytoskeleton organization (GO:0060052)2.56002799
130glial cell differentiation (GO:0010001)2.55208337
131neuron remodeling (GO:0016322)2.54171012
132response to methylmercury (GO:0051597)2.54115179
133negative regulation of JUN kinase activity (GO:0043508)2.54023607
134positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.51816217
135regulation of excitatory postsynaptic membrane potential (GO:0060079)2.51782508
136amino acid import (GO:0043090)2.51700693
137response to catecholamine (GO:0071869)2.50762917
138response to monoamine (GO:0071867)2.50762917
139neuron recognition (GO:0008038)2.49942281
140L-serine transport (GO:0015825)2.49055466
141positive regulation of amino acid transport (GO:0051957)2.48967485
142adult locomotory behavior (GO:0008344)2.47832321
143thioester biosynthetic process (GO:0035384)2.47124658
144acyl-CoA biosynthetic process (GO:0071616)2.47124658
145regulation of postsynaptic membrane potential (GO:0060078)2.46940275
146cerebellum development (GO:0021549)2.46508267
147long-term memory (GO:0007616)2.45651788
148regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.44949852
149negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.44762760
150leukocyte migration involved in inflammatory response (GO:0002523)2.44670838
151glycine transport (GO:0015816)2.44567424
152gamma-aminobutyric acid signaling pathway (GO:0007214)2.44389052
153regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.42540411
154neurotransmitter uptake (GO:0001504)2.42535899
155positive regulation of dendritic spine development (GO:0060999)2.42365929
156auditory behavior (GO:0031223)2.41980134
157regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.40416518
158positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.39665552
159* regulation of neurotransmitter levels (GO:0001505)2.38877060
160cochlea development (GO:0090102)2.38744804
161neuron-neuron synaptic transmission (GO:0007270)2.35535989
162urogenital system development (GO:0001655)2.35512430
163cytoskeletal anchoring at plasma membrane (GO:0007016)2.35189559
164regulation of neuron migration (GO:2001222)2.35046085
165notochord development (GO:0030903)2.33393771
166cell-cell junction maintenance (GO:0045217)2.32736365
167glomerulus development (GO:0032835)2.29480036
168planar cell polarity pathway involved in neural tube closure (GO:0090179)2.29276579
169glial cell proliferation (GO:0014009)2.28469165
170cranial nerve development (GO:0021545)2.28063208
171cerebellar Purkinje cell layer development (GO:0021680)2.27851072
172renal system development (GO:0072001)2.27060684
173axon ensheathment in central nervous system (GO:0032291)10.2489777
174central nervous system myelination (GO:0022010)10.2489777

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.36853211
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.81287387
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.78228731
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.66631174
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.52904489
6SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.47755582
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45210050
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45210050
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.42924768
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.41972147
11* DROSHA_22980978_ChIP-Seq_HELA_Human2.41030002
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40869513
13EZH2_22144423_ChIP-Seq_EOC_Human2.38911802
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.32527031
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.29300537
16* EZH2_27294783_Chip-Seq_ESCs_Mouse2.25207541
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.21532659
18ZFP281_18757296_ChIP-ChIP_E14_Mouse2.21487619
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16202041
20* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.12682624
21* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09967112
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.09077026
23ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.06931854
24* RARB_27405468_Chip-Seq_BRAIN_Mouse2.06315918
25* EED_16625203_ChIP-ChIP_MESCs_Mouse2.01804808
26TAF15_26573619_Chip-Seq_HEK293_Human1.93272815
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.92345309
28SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.92027229
29* RNF2_27304074_Chip-Seq_ESCs_Mouse1.90320197
30RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.88637984
31OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.79290636
32* REST_21632747_ChIP-Seq_MESCs_Mouse1.73359090
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70332956
34NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.66821264
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.65249343
36TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.62446048
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.58581740
38KDM2B_26808549_Chip-Seq_K562_Human1.57922363
39* REST_18959480_ChIP-ChIP_MESCs_Mouse1.54246352
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.54073719
41* AR_21572438_ChIP-Seq_LNCaP_Human1.53802056
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53219187
43ER_23166858_ChIP-Seq_MCF-7_Human1.48297438
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47552702
45ZFP281_27345836_Chip-Seq_ESCs_Mouse1.44187423
46DNAJC2_21179169_ChIP-ChIP_NT2_Human1.42815662
47* SMAD3_21741376_ChIP-Seq_EPCs_Human1.42157145
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42078220
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.37609740
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36993674
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34791049
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33952187
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.33129923
54TP53_20018659_ChIP-ChIP_R1E_Mouse1.32732299
55* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31606868
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.31461438
57RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29443470
58NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.29179928
59TRIM28_21343339_ChIP-Seq_HEK293_Human1.28619326
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28204664
61ISL1_27105846_Chip-Seq_CPCs_Mouse1.28102933
62CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.27603810
63SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.26026833
64VDR_22108803_ChIP-Seq_LS180_Human1.25057803
65SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.23472940
66* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.23302006
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22101345
68BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21407086
69CLOCK_20551151_ChIP-Seq_293T_Human1.21334155
70GATA1_26923725_Chip-Seq_HPCs_Mouse1.19636502
71ESR1_15608294_ChIP-ChIP_MCF-7_Human1.19477698
72WT1_19549856_ChIP-ChIP_CCG9911_Human1.19411154
73TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18717460
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18362507
75P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17838865
76NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15352322
77ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.15265304
78* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14464830
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14058614
80NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.13177654
81STAT3_23295773_ChIP-Seq_U87_Human1.13144294
82RING1B_27294783_Chip-Seq_ESCs_Mouse1.12493860
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11311268
84* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11247086
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10947498
86GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10927057
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10664079
88RNF2_27304074_Chip-Seq_NSC_Mouse1.10307878
89EOMES_21245162_ChIP-Seq_HESCs_Human1.10110874
90* ERG_21242973_ChIP-ChIP_JURKAT_Human1.09576995
91RING1B_27294783_Chip-Seq_NPCs_Mouse1.09371695
92P300_19829295_ChIP-Seq_ESCs_Human1.07787148
93EP300_21415370_ChIP-Seq_HL-1_Mouse1.06028402
94NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05547675
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05547675
96NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04678960
97LXR_22292898_ChIP-Seq_THP-1_Human1.03354995
98PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02355578
99ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02042001
100MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01306907
101SMAD4_21799915_ChIP-Seq_A2780_Human1.01301887
102FUS_26573619_Chip-Seq_HEK293_Human1.01133859
103SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00480968
104* SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.00422175
105POU5F1_16518401_ChIP-PET_MESCs_Mouse1.00309613
106EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99813501
107TCF4_23295773_ChIP-Seq_U87_Human0.99666020
108* SOX2_21211035_ChIP-Seq_LN229_Gbm0.99647007
109FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98979217
110TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98658623
111* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98236013
112GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96830992
113ESR1_21235772_ChIP-Seq_MCF-7_Human0.96573175
114* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95402062
115RUNX1_26923725_Chip-Seq_HPCs_Mouse0.93933768
116DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93592212
117MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93240847
118PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92957397
119* SMAD3_21741376_ChIP-Seq_ESCs_Human0.92477726
120PRDM14_20953172_ChIP-Seq_ESCs_Human0.91831097
121AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91485201
122POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.91430481
123TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90687974
124EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90610010
125OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90271753
126* AR_19668381_ChIP-Seq_PC3_Human0.89869910
127CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89616249
128* SMAD3_21741376_ChIP-Seq_HESCs_Human0.89200793
129EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89148970
130WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88947985
131STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.88516020
132SOX9_26525672_Chip-Seq_HEART_Mouse0.87778910
133CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87331678
134ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87059129
135* TET1_21490601_ChIP-Seq_MESCs_Mouse0.87010608
136SMAD4_21741376_ChIP-Seq_HESCs_Human0.86653242
137ZNF274_21170338_ChIP-Seq_K562_Hela0.86624230
138LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86594137
139GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.85833774
140TBL1_22424771_ChIP-Seq_293T_Human0.85368096
141CTCF_27219007_Chip-Seq_Bcells_Human0.85325523
142SMC4_20622854_ChIP-Seq_HELA_Human0.84944569
143* FOXA2_19822575_ChIP-Seq_HepG2_Human0.83452450
144TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.81908227
145EGR1_19032775_ChIP-ChIP_M12_Human0.81164030
146* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80704779
147TCF3_18692474_ChIP-Seq_MESCs_Mouse0.80476554
148TCF3_18692474_ChIP-Seq_MEFs_Mouse0.78883914

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.12538273
2MP0000920_abnormal_myelination4.60403170
3MP0004859_abnormal_synaptic_plasticity3.90530748
4MP0004270_analgesia3.83210628
5MP0001529_abnormal_vocalization3.53126367
6MP0003690_abnormal_glial_cell3.01137668
7MP0006292_abnormal_olfactory_placode2.75821708
8MP0001486_abnormal_startle_reflex2.73355039
9MP0002272_abnormal_nervous_system2.66670587
10MP0002064_seizures2.61107879
11MP0001905_abnormal_dopamine_level2.53611096
12MP0005171_absent_coat_pigmentation2.49949072
13MP0004885_abnormal_endolymph2.44920521
14MP0003635_abnormal_synaptic_transmissio2.44553115
15MP0000778_abnormal_nervous_system2.35038470
16MP0009745_abnormal_behavioral_response2.33162350
17MP0003329_amyloid_beta_deposits2.29920144
18MP0003634_abnormal_glial_cell2.28715817
19MP0003122_maternal_imprinting2.23324833
20MP0004142_abnormal_muscle_tone2.23294728
21MP0009046_muscle_twitch2.17634048
22MP0004742_abnormal_vestibular_system2.15592650
23MP0003950_abnormal_plasma_membrane2.11072830
24MP0001485_abnormal_pinna_reflex2.05268032
25MP0002822_catalepsy1.98357657
26MP0005423_abnormal_somatic_nervous1.95077700
27MP0002638_abnormal_pupillary_reflex1.91204743
28MP0002734_abnormal_mechanical_nocicepti1.89677535
29MP0003632_abnormal_nervous_system1.80957146
30MP0000537_abnormal_urethra_morphology1.79875627
31MP0010030_abnormal_orbit_morphology1.77420660
32MP0005670_abnormal_white_adipose1.77187469
33MP0002063_abnormal_learning/memory/cond1.76866707
34MP0002229_neurodegeneration1.76727155
35MP0003879_abnormal_hair_cell1.75809805
36MP0005451_abnormal_body_composition1.75477835
37MP0000955_abnormal_spinal_cord1.72873377
38MP0002572_abnormal_emotion/affect_behav1.70961698
39MP0005409_darkened_coat_color1.67897749
40MP0001440_abnormal_grooming_behavior1.65832288
41MP0004924_abnormal_behavior1.60988180
42MP0005386_behavior/neurological_phenoty1.60988180
43MP0003890_abnormal_embryonic-extraembry1.59882508
44MP0002882_abnormal_neuron_morphology1.54725665
45MP0001299_abnormal_eye_distance/1.48997465
46MP0003123_paternal_imprinting1.48955999
47MP0008569_lethality_at_weaning1.47401342
48MP0005551_abnormal_eye_electrophysiolog1.45587425
49MP0002066_abnormal_motor_capabilities/c1.42445443
50MP0004043_abnormal_pH_regulation1.41640808
51MP0000462_abnormal_digestive_system1.37371870
52MP0003136_yellow_coat_color1.37274459
53MP0002067_abnormal_sensory_capabilities1.36365457
54MP0004147_increased_porphyrin_level1.33727648
55MP0003878_abnormal_ear_physiology1.32973536
56MP0005377_hearing/vestibular/ear_phenot1.32973536
57MP0003631_nervous_system_phenotype1.30925240
58MP0004381_abnormal_hair_follicle1.25343384
59MP0000566_synostosis1.24321607
60MP0000383_abnormal_hair_follicle1.23103341
61MP0001970_abnormal_pain_threshold1.21075272
62MP0001188_hyperpigmentation1.20399569
63MP0002733_abnormal_thermal_nociception1.20174025
64MP0001502_abnormal_circadian_rhythm1.19672906
65MP0000747_muscle_weakness1.19433083
66MP0005623_abnormal_meninges_morphology1.19170580
67MP0002752_abnormal_somatic_nervous1.18322601
68MP0010678_abnormal_skin_adnexa1.17685830
69MP0000534_abnormal_ureter_morphology1.16657438
70MP0002249_abnormal_larynx_morphology1.16367512
71MP0001346_abnormal_lacrimal_gland1.16026012
72MP0005410_abnormal_fertilization1.15481522
73MP0002089_abnormal_postnatal_growth/wei1.15361509
74MP0000604_amyloidosis1.13350721
75MP0001968_abnormal_touch/_nociception1.12915028
76MP0005257_abnormal_intraocular_pressure1.08048033
77MP0003861_abnormal_nervous_system1.07142170
78MP0008260_abnormal_autophagy1.06622403
79MP0004811_abnormal_neuron_physiology1.06329623
80MP0003633_abnormal_nervous_system1.06135884
81MP0003119_abnormal_digestive_system1.06088625
82MP0001177_atelectasis1.05443059
83MP0000049_abnormal_middle_ear1.02467688
84MP0002184_abnormal_innervation1.02182864
85MP0004215_abnormal_myocardial_fiber0.97865539
86MP0002697_abnormal_eye_size0.97065871
87MP0002152_abnormal_brain_morphology0.96499902
88MP0005408_hypopigmentation0.95032376
89MP0001501_abnormal_sleep_pattern0.94369823
90MP0001849_ear_inflammation0.94244387
91MP0003942_abnormal_urinary_system0.94063591
92MP0004858_abnormal_nervous_system0.92507807
93MP0001963_abnormal_hearing_physiology0.92363354
94MP0000428_abnormal_craniofacial_morphol0.91120997
95MP0002557_abnormal_social/conspecific_i0.90419881
96MP0009672_abnormal_birth_weight0.88246212
97MP0001661_extended_life_span0.87823355
98MP0005058_abnormal_lysosome_morphology0.86971786
99MP0003195_calcinosis0.86461664
100MP0002735_abnormal_chemical_nociception0.86436409
101MP0009379_abnormal_foot_pigmentation0.85909479
102MP0005195_abnormal_posterior_eye0.83634448
103MP0010386_abnormal_urinary_bladder0.83231214
104MP0000579_abnormal_nail_morphology0.82533218
105MP0002736_abnormal_nociception_after0.80625891
106MP0004145_abnormal_muscle_electrophysio0.78586191
107MP0005076_abnormal_cell_differentiation0.77655636
108MP0005646_abnormal_pituitary_gland0.77636935
109MP0003385_abnormal_body_wall0.76465870
110MP0003121_genomic_imprinting0.75831418
111MP0003315_abnormal_perineum_morphology0.74946018
112MP0001286_abnormal_eye_development0.74806739
113MP0006072_abnormal_retinal_apoptosis0.74367490
114MP0003938_abnormal_ear_development0.73018272
115MP0004134_abnormal_chest_morphology0.72965033
116MP0005248_abnormal_Harderian_gland0.72390496
117MP0006276_abnormal_autonomic_nervous0.71775963
118MP0003567_abnormal_fetal_cardiomyocyte0.71679864
119MP0002090_abnormal_vision0.71575616
120MP0001293_anophthalmia0.71219151
121MP0003075_altered_response_to0.69703456
122MP0002751_abnormal_autonomic_nervous0.68697480
123MP0009780_abnormal_chondrocyte_physiolo0.68122075
124MP0005253_abnormal_eye_physiology0.66883185
125MP0000762_abnormal_tongue_morphology0.66396726
126MP0000631_abnormal_neuroendocrine_gland0.65202910
127MP0003137_abnormal_impulse_conducting0.65059857
128MP0002295_abnormal_pulmonary_circulatio0.60240222
129MP0000639_abnormal_adrenal_gland0.59754202
130MP0003806_abnormal_nucleotide_metabolis0.59627964
131MP0000026_abnormal_inner_ear0.59254252
132MP0000647_abnormal_sebaceous_gland0.58573737
133MP0008874_decreased_physiological_sensi0.58554391
134MP0004133_heterotaxia0.57352014
135MP0001984_abnormal_olfaction0.57208780
136MP0004085_abnormal_heartbeat0.56790703
137MP0002069_abnormal_eating/drinking_beha0.56240997
138MP0000751_myopathy0.56107415

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.96418213
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.38709552
3Degeneration of the lateral corticospinal tracts (HP:0002314)5.38709552
4Sensory axonal neuropathy (HP:0003390)5.18370519
5Cerebral hypomyelination (HP:0006808)4.96346488
6Peripheral hypomyelination (HP:0007182)4.70719601
7Ulnar claw (HP:0001178)4.60453672
8Cerebral inclusion bodies (HP:0100314)4.45144537
9Abnormality of the corticospinal tract (HP:0002492)4.37070261
10Myokymia (HP:0002411)4.24479573
11Parakeratosis (HP:0001036)4.08907484
12Supranuclear gaze palsy (HP:0000605)4.01257507
13Segmental peripheral demyelination/remyelination (HP:0003481)3.99661406
14Alacrima (HP:0000522)3.87054879
15Intention tremor (HP:0002080)3.80634010
16Abnormal auditory evoked potentials (HP:0006958)3.75757422
17Spastic gait (HP:0002064)3.54181494
18Onion bulb formation (HP:0003383)3.46857148
19Dysmetria (HP:0001310)3.38456446
20Hypoplastic pelvis (HP:0008839)3.30473697
21Decreased lacrimation (HP:0000633)3.16114722
22Akinesia (HP:0002304)3.07456572
23Spastic paraparesis (HP:0002313)2.99737163
24Leukodystrophy (HP:0002415)2.98406983
25Febrile seizures (HP:0002373)2.92527376
26Scanning speech (HP:0002168)2.86087030
27Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.82003208
28Aplasia involving bones of the upper limbs (HP:0009823)2.80065570
29Aplasia of the phalanges of the hand (HP:0009802)2.80065570
30Aplasia involving bones of the extremities (HP:0009825)2.80065570
31Pheochromocytoma (HP:0002666)2.79553126
32Abnormality of cochlea (HP:0000375)2.74895150
33Partial duplication of thumb phalanx (HP:0009944)2.66771518
34CNS hypomyelination (HP:0003429)2.65047393
35Morphological abnormality of the inner ear (HP:0011390)2.64193307
36Ankle clonus (HP:0011448)2.59315651
37Shawl scrotum (HP:0000049)2.59182470
38Absent septum pellucidum (HP:0001331)2.57415650
39Atonic seizures (HP:0010819)2.51218300
40Obstructive sleep apnea (HP:0002870)2.48878197
41Shallow orbits (HP:0000586)2.48345983
42Megalencephaly (HP:0001355)2.47330389
43Bronchomalacia (HP:0002780)2.45673906
44Abnormality of glycolysis (HP:0004366)2.45151811
45Increased serum pyruvate (HP:0003542)2.45151811
46Premature skin wrinkling (HP:0100678)2.43710720
47Neuroendocrine neoplasm (HP:0100634)2.43537116
48Cerebral hemorrhage (HP:0001342)2.40371441
49Termporal pattern (HP:0011008)2.40078171
50Insidious onset (HP:0003587)2.40078171
51Coronal craniosynostosis (HP:0004440)2.38908555
52Generalized tonic-clonic seizures (HP:0002069)2.38659975
53Cutaneous finger syndactyly (HP:0010554)2.38646431
54Increased circulating renin level (HP:0000848)2.37401132
55Partial duplication of the phalanx of hand (HP:0009999)2.36585370
56Abnormality of the foot musculature (HP:0001436)2.34479128
57Thickened helices (HP:0000391)2.32418305
58Clumsiness (HP:0002312)2.32194274
59Stridor (HP:0010307)2.31691406
60Focal motor seizures (HP:0011153)2.31425156
61Split foot (HP:0001839)2.30598359
62Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.30050488
63Decreased motor nerve conduction velocity (HP:0003431)2.28166416
64Hepatoblastoma (HP:0002884)2.27588871
65Limb dystonia (HP:0002451)2.26894018
66Congenital ichthyosiform erythroderma (HP:0007431)2.26754426
67Retinal dysplasia (HP:0007973)2.25058779
68Action tremor (HP:0002345)2.23819090
69White forelock (HP:0002211)2.22238506
70Partial agenesis of the corpus callosum (HP:0001338)2.21843707
71Slow saccadic eye movements (HP:0000514)2.21643021
72Progressive inability to walk (HP:0002505)2.19333000
73Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.18313257
74Abnormality of the septum pellucidum (HP:0007375)2.17281396
75Septo-optic dysplasia (HP:0100842)2.17280734
76Cutaneous syndactyly (HP:0012725)2.14571522
77Vaginal atresia (HP:0000148)2.14445982
78Lower limb muscle weakness (HP:0007340)2.13836070
79Torticollis (HP:0000473)2.09773971
80Patchy hypopigmentation of hair (HP:0011365)2.08787358
81Bowel incontinence (HP:0002607)2.08732088
82Abnormality of the labia minora (HP:0012880)2.05850657
83Turricephaly (HP:0000262)2.05118955
84Right ventricular cardiomyopathy (HP:0011663)2.05002310
85Focal seizures (HP:0007359)2.00824331
86Abnormal umbilical cord blood vessels (HP:0011403)2.00561083
87Single umbilical artery (HP:0001195)2.00561083
88Abnormality of the fetal cardiovascular system (HP:0010948)2.00561083
89Renal Fanconi syndrome (HP:0001994)2.00376703
90Synostosis involving the elbow (HP:0003938)1.99994438
91Humeroradial synostosis (HP:0003041)1.99994438
92Choanal stenosis (HP:0000452)1.99786999
93Genital tract atresia (HP:0001827)1.99597027
94Abnormality of binocular vision (HP:0011514)1.98786850
95Diplopia (HP:0000651)1.98786850
96Paraparesis (HP:0002385)1.97183751
97Abnormality of the salivary glands (HP:0010286)1.97108090
98Anteriorly placed anus (HP:0001545)1.96928136
99Sleep apnea (HP:0010535)1.96897840
100Hypoplasia of the iris (HP:0007676)1.96733300
101Abnormal ventriculo-arterial connection (HP:0011563)1.96127499
102Transposition of the great arteries (HP:0001669)1.96127499
103Abnormal connection of the cardiac segments (HP:0011545)1.96127499
104Dysdiadochokinesis (HP:0002075)1.94957214
105Infantile muscular hypotonia (HP:0008947)1.93645538
106Morphological abnormality of the pyramidal tract (HP:0002062)1.92809182
107Metabolic alkalosis (HP:0200114)1.92745313
108Abnormality of the phalanges of the 2nd finger (HP:0009541)1.91717006
109Abnormal large intestine physiology (HP:0012700)1.91143996
110Neoplasm of the heart (HP:0100544)1.90270059
111Autoamputation (HP:0001218)1.90172698
112Absent epiphyses (HP:0010577)1.89627140
113Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.89627140
114Choreoathetosis (HP:0001266)1.89273564
115Cupped ear (HP:0000378)1.88751341
116Back pain (HP:0003418)1.87287839
117Hypomagnesemia (HP:0002917)1.87255311
118Midline defect of the nose (HP:0004122)1.87242264
119Trigonocephaly (HP:0000243)1.87043769
120Hepatosplenomegaly (HP:0001433)1.86271967
121Distal sensory impairment (HP:0002936)1.84497160
122Abnormality of the middle phalanges of the toes (HP:0010183)1.83668724
123Abnormality of the musculature of the hand (HP:0001421)1.80861555
124Status epilepticus (HP:0002133)1.80192045
125Conical tooth (HP:0000698)1.79699137
126Esophageal atresia (HP:0002032)1.79384285
127Foot dorsiflexor weakness (HP:0009027)1.78535330
128Urinary incontinence (HP:0000020)1.77790744
129Small epiphyses (HP:0010585)1.77667269
130Progressive cerebellar ataxia (HP:0002073)1.77195265
131Steppage gait (HP:0003376)1.76616213
132Diminished movement (HP:0002374)1.76435250
133Broad-based gait (HP:0002136)1.75319545
134Epileptic encephalopathy (HP:0200134)1.74357934
135Arnold-Chiari malformation (HP:0002308)1.74319846
136Muscle fiber splitting (HP:0003555)1.74290425
137Absence seizures (HP:0002121)1.74266128
138Supernumerary ribs (HP:0005815)1.72781984
139Postural instability (HP:0002172)1.72678322
140Anxiety (HP:0000739)1.72676296
141Hammertoe (HP:0001765)1.71945019
142Dialeptic seizures (HP:0011146)1.71765208
143Fetal akinesia sequence (HP:0001989)1.71246680
144Clonus (HP:0002169)1.70720527
145Abnormality of the lower motor neuron (HP:0002366)1.70711444
146Broad metatarsal (HP:0001783)1.70523711
147Myelomeningocele (HP:0002475)1.69910165
148Aplasia/Hypoplasia of the sternum (HP:0006714)1.68123122
149Bicornuate uterus (HP:0000813)1.65848314
150Mixed hearing impairment (HP:0000410)1.64923046
151Omphalocele (HP:0001539)1.62490287
152Facial shape deformation (HP:0011334)1.62350902
153Potter facies (HP:0002009)1.62350902
154Lower limb amyotrophy (HP:0007210)1.60930698
155Abnormality of the aortic arch (HP:0012303)1.60159209
156Insomnia (HP:0100785)1.59119778
157Bundle branch block (HP:0011710)1.57661934
158Maternal diabetes (HP:0009800)1.57369363
159Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.56341621
160Preaxial foot polydactyly (HP:0001841)1.54976670
161Annular pancreas (HP:0001734)1.53648958

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.21586011
2OXSR14.26418311
3BCR3.59445332
4WNK43.33744458
5EPHB13.32732947
6TNIK3.27963413
7CDK193.00266984
8RIPK12.86749833
9EPHA42.60963646
10CSNK1G32.43673303
11FGFR22.37257162
12TRIB32.24239575
13LIMK12.22960868
14CSNK1A1L2.17385218
15WNK12.11513447
16DDR22.04585619
17CSNK1G11.96659895
18CSNK1G21.94420590
19PKN11.91697522
20PBK1.88575748
21ICK1.81847803
22PRPF4B1.71631123
23NTRK11.71276400
24NEK61.68236695
25UHMK11.66165079
26LATS21.59950541
27SGK21.59039396
28PAK61.56096477
29PNCK1.55747981
30ROCK21.50012049
31CAMK2B1.49045239
32FGFR41.48733654
33MET1.37152430
34PDGFRA1.33944126
35CAMK2D1.31932887
36SGK31.27757286
37CDK141.23864285
38MARK11.19943918
39FGFR11.15801092
40ARAF1.15741757
41MAPKAPK51.13521488
42NTRK31.11271777
43CAMK2G1.07264112
44FGR1.06873134
45CDK51.06330181
46CDK151.04550821
47SGK4941.01705159
48SGK2231.01705159
49CDK181.00252748
50CDK11A0.97308967
51SIK10.96292762
52ERBB20.95655797
53CLK10.93554354
54CAMK10.90925330
55PHKG20.87141477
56PHKG10.87141477
57TYRO30.84941892
58PIK3CA0.84276836
59CAMK2A0.84030594
60NTRK20.83028319
61TESK20.82973611
62MARK20.82649064
63EPHB20.80335654
64BRSK10.80137746
65PLK40.79784724
66PAK30.79722984
67EEF2K0.79311560
68MAP3K90.78989598
69SIK20.78747265
70PRKCQ0.77989585
71LMTK20.74244605
72MINK10.72542248
73DYRK20.71275382
74RET0.70782355
75MAP2K60.70123404
76WNK30.69015585
77PDPK10.66007825
78FYN0.65364767
79CASK0.65088403
80BRD40.62879224
81PDK20.62493750
82FGFR30.62073065
83MKNK20.61032282
84DMPK0.60477378
85MAPK130.60117316
86PRKDC0.56749154
87CSNK1D0.55613832
88PDGFRB0.55402941
89ERBB40.54793355
90CAMK40.54746501
91PTK20.53282992
92FES0.52821302
93MAPK120.52726244
94TRPM70.51324569
95MST40.49515260
96CDC70.48748615
97KSR10.48702888
98PRKCH0.47920860
99MAP2K10.47846913
100STK110.47103653
101PRKCE0.46967200
102CDK120.46181101
103TTK0.45491850
104PRKD10.45308139
105ACVR1B0.45072053
106CSNK1A10.45020168
107MTOR0.44638359
108DYRK1B0.43314830
109GSK3B0.41147780
110PDK10.40806643
111KSR20.39581134
112CDK30.39543331
113ROCK10.38662076
114PLK20.36047263
115PRKACB0.35924765
116PRKG10.33498435
117MAPK70.32771257
118PRKCG0.32581864
119GSK3A0.31651403
120DAPK20.31487267
121DYRK1A0.30825108
122NME10.30141972
123CSNK1E0.29644962
124MAPK100.28879786
125MAP3K20.28202957
126MAP3K40.27182391
127MAP3K130.26910944
128PRKACA0.26741208
129PINK10.25958943
130IRAK20.25111512
131CAMKK10.23598344
132CAMK1G0.23519668
133PRKD30.23116805
134SGK10.22946414
135PAK10.22287070
136MUSK0.22203547
137OBSCN0.21232929
138GRK50.21185252
139RPS6KA30.19166749
140PTK2B0.18654822
141ALK0.18302533
142PRKCZ0.18041381

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.09505647
2Steroid biosynthesis_Homo sapiens_hsa001004.39139498
3Fatty acid elongation_Homo sapiens_hsa000623.33932460
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.21515439
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.01112308
6Ether lipid metabolism_Homo sapiens_hsa005652.39740075
7Axon guidance_Homo sapiens_hsa043602.30767415
8Oxidative phosphorylation_Homo sapiens_hsa001902.12277483
9GABAergic synapse_Homo sapiens_hsa047271.94697739
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.94519873
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91615015
12Glutamatergic synapse_Homo sapiens_hsa047241.74077473
13Synaptic vesicle cycle_Homo sapiens_hsa047211.67485655
14Sulfur metabolism_Homo sapiens_hsa009201.64988772
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.63749535
16Morphine addiction_Homo sapiens_hsa050321.62937728
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.61670797
18Parkinsons disease_Homo sapiens_hsa050121.60971133
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.54170546
20Butanoate metabolism_Homo sapiens_hsa006501.53092376
21Bile secretion_Homo sapiens_hsa049761.52438124
22Alzheimers disease_Homo sapiens_hsa050101.50579861
23Serotonergic synapse_Homo sapiens_hsa047261.49896163
24Cocaine addiction_Homo sapiens_hsa050301.47108592
25Nicotine addiction_Homo sapiens_hsa050331.45750330
26Collecting duct acid secretion_Homo sapiens_hsa049661.43516979
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.42561969
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.39442238
29Circadian entrainment_Homo sapiens_hsa047131.38765197
30Thyroid hormone synthesis_Homo sapiens_hsa049181.37388721
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.35602602
32Nitrogen metabolism_Homo sapiens_hsa009101.33488470
33Vibrio cholerae infection_Homo sapiens_hsa051101.33317633
34Arginine biosynthesis_Homo sapiens_hsa002201.27638731
35Sphingolipid metabolism_Homo sapiens_hsa006001.27248309
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.25615249
37Cardiac muscle contraction_Homo sapiens_hsa042601.22623124
38Cholinergic synapse_Homo sapiens_hsa047251.22620767
39Circadian rhythm_Homo sapiens_hsa047101.20574432
40Long-term depression_Homo sapiens_hsa047301.17483749
41Dopaminergic synapse_Homo sapiens_hsa047281.13010292
42Salivary secretion_Homo sapiens_hsa049701.10141340
43Arginine and proline metabolism_Homo sapiens_hsa003301.09517951
44Basal cell carcinoma_Homo sapiens_hsa052171.08171154
45Estrogen signaling pathway_Homo sapiens_hsa049151.07088116
46Olfactory transduction_Homo sapiens_hsa047401.06682545
47Protein export_Homo sapiens_hsa030601.06102897
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05876183
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05352641
50Linoleic acid metabolism_Homo sapiens_hsa005911.04511971
51Vitamin B6 metabolism_Homo sapiens_hsa007501.03379352
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.02701423
53beta-Alanine metabolism_Homo sapiens_hsa004101.00758341
54Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.00201467
55Renal cell carcinoma_Homo sapiens_hsa052110.99671011
56Wnt signaling pathway_Homo sapiens_hsa043100.96738233
57Hippo signaling pathway_Homo sapiens_hsa043900.96461039
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95859520
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92112162
60Gastric acid secretion_Homo sapiens_hsa049710.91775680
61Amphetamine addiction_Homo sapiens_hsa050310.91389789
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89783656
63Endocytosis_Homo sapiens_hsa041440.88605009
64Biosynthesis of amino acids_Homo sapiens_hsa012300.84231862
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.83032772
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82054148
67Phototransduction_Homo sapiens_hsa047440.81766898
68Rheumatoid arthritis_Homo sapiens_hsa053230.81311540
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81021203
70Long-term potentiation_Homo sapiens_hsa047200.80784158
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.80776799
72Tight junction_Homo sapiens_hsa045300.79835288
73Phenylalanine metabolism_Homo sapiens_hsa003600.79160068
74Prion diseases_Homo sapiens_hsa050200.77949071
75Glucagon signaling pathway_Homo sapiens_hsa049220.76265046
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75977872
77Ras signaling pathway_Homo sapiens_hsa040140.75129374
78Gap junction_Homo sapiens_hsa045400.74712758
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74613119
80Histidine metabolism_Homo sapiens_hsa003400.73535759
81Fatty acid metabolism_Homo sapiens_hsa012120.72968731
82Oocyte meiosis_Homo sapiens_hsa041140.72819283
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71797343
84Oxytocin signaling pathway_Homo sapiens_hsa049210.71349097
85Propanoate metabolism_Homo sapiens_hsa006400.68442950
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.67789826
87Rap1 signaling pathway_Homo sapiens_hsa040150.67667836
88Renin secretion_Homo sapiens_hsa049240.67630607
89Huntingtons disease_Homo sapiens_hsa050160.67518373
90Glioma_Homo sapiens_hsa052140.67461408
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66894118
92Ovarian steroidogenesis_Homo sapiens_hsa049130.65542875
93ErbB signaling pathway_Homo sapiens_hsa040120.65538905
94Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65307408
95AMPK signaling pathway_Homo sapiens_hsa041520.64010649
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63812242
97Calcium signaling pathway_Homo sapiens_hsa040200.62992546
98Protein digestion and absorption_Homo sapiens_hsa049740.61963222
99Pancreatic secretion_Homo sapiens_hsa049720.61807512
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61739362
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61495089
102Lysosome_Homo sapiens_hsa041420.61069020
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59017998
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58874814
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58725888
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58230763
107Insulin signaling pathway_Homo sapiens_hsa049100.58045367
108cAMP signaling pathway_Homo sapiens_hsa040240.57263336
109Taste transduction_Homo sapiens_hsa047420.57021956
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.56126874
111Dorso-ventral axis formation_Homo sapiens_hsa043200.53652850
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52832571
113Insulin secretion_Homo sapiens_hsa049110.52773584
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51801230
115Endometrial cancer_Homo sapiens_hsa052130.49938838
116Alcoholism_Homo sapiens_hsa050340.49424319
117ECM-receptor interaction_Homo sapiens_hsa045120.49366861
118Inositol phosphate metabolism_Homo sapiens_hsa005620.48903414
119Adherens junction_Homo sapiens_hsa045200.48470908
120Phagosome_Homo sapiens_hsa041450.48016254
121Notch signaling pathway_Homo sapiens_hsa043300.47919511
122Vitamin digestion and absorption_Homo sapiens_hsa049770.47662655
123Carbon metabolism_Homo sapiens_hsa012000.47603183
124Arachidonic acid metabolism_Homo sapiens_hsa005900.47497658
125Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47310813
126Glutathione metabolism_Homo sapiens_hsa004800.46780055
127Choline metabolism in cancer_Homo sapiens_hsa052310.46721323
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46357871
129Fat digestion and absorption_Homo sapiens_hsa049750.46152055
130Fatty acid biosynthesis_Homo sapiens_hsa000610.45458672
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.44971893
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44935730
133Hedgehog signaling pathway_Homo sapiens_hsa043400.44904620
134PPAR signaling pathway_Homo sapiens_hsa033200.43509101
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42478407
136Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42279772
137Pyruvate metabolism_Homo sapiens_hsa006200.40789942
138MAPK signaling pathway_Homo sapiens_hsa040100.40491464
139Steroid hormone biosynthesis_Homo sapiens_hsa001400.39992214
140GnRH signaling pathway_Homo sapiens_hsa049120.39438178
141Folate biosynthesis_Homo sapiens_hsa007900.39288345
142Dilated cardiomyopathy_Homo sapiens_hsa054140.38672624
143Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37404442
144Peroxisome_Homo sapiens_hsa041460.36052535
145Melanogenesis_Homo sapiens_hsa049160.33464619
146Mineral absorption_Homo sapiens_hsa049780.30530355

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