PRIMPOL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a DNA primase-polymerase that belongs to a superfamily of archaeao-eukaryotic primases. Members of this family have primase activity, catalyzing the synthesis of short RNA primers that serve as starting points for DNA synthesis, as well as DNA polymerase activity. The encoded protein facilitates DNA damage tolerance by mediating uninterrupted fork progression after UV irradiation and reinitiating DNA synthesis. An allelic variant in this gene is associated with myopia 22. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)5.47307573
2ribosomal small subunit assembly (GO:0000028)4.95112285
3regulation of meiosis I (GO:0060631)4.27021205
4positive regulation of gamma-delta T cell activation (GO:0046645)4.18256849
5telomere maintenance via semi-conservative replication (GO:0032201)4.17465662
6DNA replication initiation (GO:0006270)4.10734847
7deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.08782731
8centriole replication (GO:0007099)4.08020201
9DNA strand elongation involved in DNA replication (GO:0006271)4.02583597
10DNA strand elongation (GO:0022616)3.97324749
11telomere maintenance via recombination (GO:0000722)3.96941317
12DNA unwinding involved in DNA replication (GO:0006268)3.82231628
13platelet dense granule organization (GO:0060155)3.78618045
14mitotic recombination (GO:0006312)3.78304939
15DNA double-strand break processing (GO:0000729)3.72770451
16maturation of SSU-rRNA (GO:0030490)3.68813485
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.67395862
18pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.60517138
19proteasome assembly (GO:0043248)3.56494312
20protein localization to kinetochore (GO:0034501)3.55904536
21nuclear pore complex assembly (GO:0051292)3.53355514
22nuclear pore organization (GO:0006999)3.52852349
23synapsis (GO:0007129)3.52264536
24reciprocal DNA recombination (GO:0035825)3.50651684
25reciprocal meiotic recombination (GO:0007131)3.50651684
26purine-containing compound salvage (GO:0043101)3.50264333
27anterograde synaptic vesicle transport (GO:0048490)3.50263618
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.49092558
29antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.49092558
30cullin deneddylation (GO:0010388)3.45917502
31DNA replication checkpoint (GO:0000076)3.38565646
32sequestering of actin monomers (GO:0042989)3.38171975
33DNA catabolic process, exonucleolytic (GO:0000738)3.35008932
34deoxyribose phosphate catabolic process (GO:0046386)3.34998720
35adenosine metabolic process (GO:0046085)3.34876817
36viral mRNA export from host cell nucleus (GO:0046784)3.33574573
37regulation of gamma-delta T cell differentiation (GO:0045586)3.32108976
38DNA replication-dependent nucleosome assembly (GO:0006335)3.31682760
39DNA replication-dependent nucleosome organization (GO:0034723)3.31682760
40mitotic nuclear envelope disassembly (GO:0007077)3.31199998
41pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.31154373
42telomere maintenance via telomere lengthening (GO:0010833)3.30541991
43seminiferous tubule development (GO:0072520)3.27254063
44protein deneddylation (GO:0000338)3.26913254
45telomere maintenance (GO:0000723)3.25528993
46nucleotide-excision repair, DNA gap filling (GO:0006297)3.24166518
47histone exchange (GO:0043486)3.23353771
48telomere organization (GO:0032200)3.21513548
49nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.18974602
50pyrimidine nucleotide catabolic process (GO:0006244)3.17210297
51male meiosis I (GO:0007141)3.15802599
52exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.12150132
53deoxyribonucleotide catabolic process (GO:0009264)3.10971671
54antigen processing and presentation of endogenous antigen (GO:0019883)3.09507953
55regulation of B cell differentiation (GO:0045577)3.08405519
56meiosis I (GO:0007127)3.07425660
57aggressive behavior (GO:0002118)3.06161093
58deoxyribose phosphate metabolic process (GO:0019692)3.05813034
59regulation of gamma-delta T cell activation (GO:0046643)3.02658077
60DNA ligation (GO:0006266)3.02585398
61membrane disassembly (GO:0030397)3.01927669
62nuclear envelope disassembly (GO:0051081)3.01927669
63resolution of meiotic recombination intermediates (GO:0000712)3.01204098
64* postreplication repair (GO:0006301)3.00270778
65deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.00262600
66protein localization to chromosome, centromeric region (GO:0071459)2.99790636
67mitotic chromosome condensation (GO:0007076)2.99089465
68double-strand break repair via homologous recombination (GO:0000724)2.97724452
69viral transcription (GO:0019083)2.97713530
70regulation of Golgi to plasma membrane protein transport (GO:0042996)2.97547782
71recombinational repair (GO:0000725)2.97408894
72regulation of cilium movement (GO:0003352)2.97331663
73interferon-gamma production (GO:0032609)2.96979793
74regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.95086858
75* maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.95069669
76RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.94814196
77translational termination (GO:0006415)2.93531964
78pore complex assembly (GO:0046931)2.92990595
79kinetochore organization (GO:0051383)2.92546188
80deoxyribonucleotide metabolic process (GO:0009262)2.88199410
81IMP biosynthetic process (GO:0006188)2.85647377
82purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.84617333
83positive regulation of B cell differentiation (GO:0045579)2.84610563
84microtubule depolymerization (GO:0007019)2.83218939
85centriole assembly (GO:0098534)2.83020673
86CENP-A containing nucleosome assembly (GO:0034080)2.81101147
87pyrimidine dimer repair (GO:0006290)2.80899756
88nucleobase biosynthetic process (GO:0046112)2.80682687
89positive regulation of histone H3-K4 methylation (GO:0051571)2.78822304
90DNA geometric change (GO:0032392)2.76526018
91DNA duplex unwinding (GO:0032508)2.75203928
92mitotic metaphase plate congression (GO:0007080)2.74865464
93regulation of DNA endoreduplication (GO:0032875)2.74828278
942-deoxyribonucleotide metabolic process (GO:0009394)2.74773488
95protein-cofactor linkage (GO:0018065)2.74607366
96meiotic chromosome segregation (GO:0045132)2.74259272
97folic acid-containing compound biosynthetic process (GO:0009396)2.73925671
98ubiquinone biosynthetic process (GO:0006744)2.73320850
99chromatin remodeling at centromere (GO:0031055)2.73283591
100* replication fork processing (GO:0031297)2.70186706
101purine nucleotide salvage (GO:0032261)2.70091467
102purine nucleobase biosynthetic process (GO:0009113)2.69833869
103DNA replication-independent nucleosome assembly (GO:0006336)2.67955501
104DNA replication-independent nucleosome organization (GO:0034724)2.67955501
105positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.66581695
106cellular ketone body metabolic process (GO:0046950)2.65847985
107ribosomal small subunit biogenesis (GO:0042274)2.65330196
108somatic diversification of immune receptors via somatic mutation (GO:0002566)2.64682556
109somatic hypermutation of immunoglobulin genes (GO:0016446)2.64682556
110translational elongation (GO:0006414)2.63940867
111B cell mediated immunity (GO:0019724)2.63555268
112formation of translation preinitiation complex (GO:0001731)2.63032213
113axoneme assembly (GO:0035082)2.62801088
114attachment of spindle microtubules to kinetochore (GO:0008608)2.61799773
115regulation of spindle organization (GO:0090224)2.59337740
116nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.58670504
117protein K6-linked ubiquitination (GO:0085020)2.58555311
118metaphase plate congression (GO:0051310)2.57792531
119male meiosis (GO:0007140)2.57582919
120mitotic sister chromatid cohesion (GO:0007064)2.55298287
121cell wall macromolecule metabolic process (GO:0044036)2.55046540
122ribosome biogenesis (GO:0042254)2.54394645
123oxidative phosphorylation (GO:0006119)2.54386300
124SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.54150433
125L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.53764156
126regulation of B cell receptor signaling pathway (GO:0050855)2.53637387
127establishment of chromosome localization (GO:0051303)2.53063044
128negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.52135530
129negative regulation of cell killing (GO:0031342)2.52135530
130intra-S DNA damage checkpoint (GO:0031573)2.51980829
131negative regulation of DNA-dependent DNA replication (GO:2000104)2.51783875
132negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.51736478
133regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.51689923
134IMP metabolic process (GO:0046040)2.50701551
135histone H2A acetylation (GO:0043968)2.50460837
136protein complex biogenesis (GO:0070271)2.49901375
137ubiquinone metabolic process (GO:0006743)2.49293329
138protein localization to chromosome (GO:0034502)2.49077295
139base-excision repair, AP site formation (GO:0006285)2.49032130
140Arp2/3 complex-mediated actin nucleation (GO:0034314)2.47532146
141regulation of double-strand break repair via homologous recombination (GO:0010569)2.47028340
142ribonucleoprotein complex biogenesis (GO:0022613)2.46969338
143DNA recombination (GO:0006310)2.46766330
144poly(A)+ mRNA export from nucleus (GO:0016973)2.46492929
145relaxation of smooth muscle (GO:0044557)2.46001788
146sister chromatid cohesion (GO:0007062)2.45821963
147negative regulation of histone methylation (GO:0031061)2.45210001
148mitochondrial respiratory chain complex I assembly (GO:0032981)2.45172896
149NADH dehydrogenase complex assembly (GO:0010257)2.45172896
150mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.45172896
151peroxisome fission (GO:0016559)2.44985633
152histone mRNA metabolic process (GO:0008334)2.44944183
153rRNA modification (GO:0000154)2.44744097
154regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.44439659
155mismatch repair (GO:0006298)2.44213010
156cotranslational protein targeting to membrane (GO:0006613)2.44144754
157ether lipid metabolic process (GO:0046485)2.44111012
158protein targeting to ER (GO:0045047)2.43859981
159thrombin receptor signaling pathway (GO:0070493)2.43835685
160deoxyribonucleotide biosynthetic process (GO:0009263)2.43363431
161regulation of acyl-CoA biosynthetic process (GO:0050812)2.43056038
162ribosome assembly (GO:0042255)2.42823819
163protein K11-linked ubiquitination (GO:0070979)2.41633223
164mitotic G2/M transition checkpoint (GO:0044818)2.41414779
165S-adenosylmethionine metabolic process (GO:0046500)2.40802097
166kinetochore assembly (GO:0051382)2.40596052
167translational initiation (GO:0006413)2.39652683
168regulation of nuclear cell cycle DNA replication (GO:0033262)2.39590487
169DNA synthesis involved in DNA repair (GO:0000731)2.38816448
170regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.38641808
171regulation of mitotic spindle checkpoint (GO:1903504)2.38641808
172DNA topological change (GO:0006265)2.38181659
173base-excision repair (GO:0006284)2.37501892
174regulation of histone H3-K9 methylation (GO:0051570)2.36833053
175somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.36583264
176somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.36583264
177isotype switching (GO:0045190)2.36583264
178DNA conformation change (GO:0071103)2.35053582
179nuclear-transcribed mRNA catabolic process (GO:0000956)2.34624420
180dosage compensation (GO:0007549)2.32924092
181regulation of histone H3-K27 methylation (GO:0061085)2.32734318

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.85786286
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.41713997
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.30771563
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.17130197
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.91493197
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.86330293
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.60732146
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.57877782
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.50977944
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.48794578
11EWS_26573619_Chip-Seq_HEK293_Human2.29788012
12FUS_26573619_Chip-Seq_HEK293_Human2.28402732
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.27182843
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.27075830
15ZNF274_21170338_ChIP-Seq_K562_Hela2.23397935
16SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.23306036
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.19419790
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.18345312
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.16457195
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.16169643
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.16057313
22VDR_22108803_ChIP-Seq_LS180_Human2.13805219
23TAF15_26573619_Chip-Seq_HEK293_Human2.09341318
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.08158892
25MYC_22102868_ChIP-Seq_BL_Human2.08086780
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.07136066
27FLI1_27457419_Chip-Seq_LIVER_Mouse2.05654352
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.02741657
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.02531713
30SALL1_21062744_ChIP-ChIP_HESCs_Human2.02487561
31NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02388417
32VDR_23849224_ChIP-Seq_CD4+_Human1.96144419
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.95313031
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.90608087
35FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.88059837
36FOXP3_21729870_ChIP-Seq_TREG_Human1.87367888
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.85468655
38JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.83214713
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.83010002
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.82786666
41MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.80715336
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.79162909
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77158108
44XRN2_22483619_ChIP-Seq_HELA_Human1.75411914
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.71629469
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.70968254
47IRF1_19129219_ChIP-ChIP_H3396_Human1.69990013
48AR_21909140_ChIP-Seq_LNCAP_Human1.69020648
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68867078
50GBX2_23144817_ChIP-Seq_PC3_Human1.67491591
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66542286
52IGF1R_20145208_ChIP-Seq_DFB_Human1.65435107
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.65002374
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63312917
55STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.62950910
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60206318
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.58556606
58SPI1_23547873_ChIP-Seq_NB4_Human1.57500437
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.56433913
60ELK1_19687146_ChIP-ChIP_HELA_Human1.55474982
61MYC_18940864_ChIP-ChIP_HL60_Human1.52485641
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52198159
63KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.51386769
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50419772
65P300_19829295_ChIP-Seq_ESCs_Human1.50084980
66HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.49916484
67E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49885941
68SCL_19346495_ChIP-Seq_HPC-7_Human1.49116424
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.47812268
70MYB_26560356_Chip-Seq_TH2_Human1.47211731
71CIITA_25753668_ChIP-Seq_RAJI_Human1.46692030
72MYB_26560356_Chip-Seq_TH1_Human1.46160226
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46055682
74STAT4_19710469_ChIP-ChIP_TH1__Mouse1.44449912
75MYB_21317192_ChIP-Seq_ERMYB_Mouse1.43236950
76NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.42498041
77DCP1A_22483619_ChIP-Seq_HELA_Human1.40915768
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.40893128
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40075646
80GABP_19822575_ChIP-Seq_HepG2_Human1.38486075
81THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37324030
82TP53_22573176_ChIP-Seq_HFKS_Human1.37176432
83YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36136696
84VDR_21846776_ChIP-Seq_THP-1_Human1.34324531
85TTF2_22483619_ChIP-Seq_HELA_Human1.32682867
86POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32240926
87GATA1_22025678_ChIP-Seq_K562_Human1.29653442
88MAF_26560356_Chip-Seq_TH1_Human1.29410217
89IRF8_21731497_ChIP-ChIP_J774_Mouse1.29267393
90HTT_18923047_ChIP-ChIP_STHdh_Human1.27743217
91NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25345631
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24274274
93ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24097308
94KDM5A_27292631_Chip-Seq_BREAST_Human1.23614462
95FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22642520
96STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22288172
97SOX2_19829295_ChIP-Seq_ESCs_Human1.21802985
98NANOG_19829295_ChIP-Seq_ESCs_Human1.21802985
99CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21694637
100CBP_20019798_ChIP-Seq_JUKART_Human1.21174946
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21174946
102RUNX1_22412390_ChIP-Seq_EML_Mouse1.21063345
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20677416
104ER_23166858_ChIP-Seq_MCF-7_Human1.20521358
105GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.19218564
106SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19191266
107SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17402242
108RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.17400060
109NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17017764
110NFE2_27457419_Chip-Seq_LIVER_Mouse1.16639579
111SRF_21415370_ChIP-Seq_HL-1_Mouse1.16392941
112SALL4_22934838_ChIP-ChIP_CD34+_Human1.15215363
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15176556
114FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14169294
115CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13289103
116HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.12647976
117NANOG_18555785_Chip-Seq_ESCs_Mouse1.12377769
118SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11328359
119NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10023069
120PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09176855
121OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08773748
122MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08768441
123MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08611925
124P53_22387025_ChIP-Seq_ESCs_Mouse1.08173365
125UTX_26944678_Chip-Seq_JUKART_Human1.07128227
126UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06807175
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06178932
128FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05923848
129FOXA1_25329375_ChIP-Seq_VCAP_Human1.05923848
130CRX_20693478_ChIP-Seq_RETINA_Mouse1.05725283
131CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05610333
132E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05474140
133PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05456622
134TFEB_21752829_ChIP-Seq_HELA_Human1.05431988
135IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04366877
136STAT3_18555785_Chip-Seq_ESCs_Mouse1.04280696
137BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03795914
138LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02239145
139GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01976804
140AR_20517297_ChIP-Seq_VCAP_Human1.01840822
141ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01752123
142SMAD4_21799915_ChIP-Seq_A2780_Human1.01356462
143RUNX_20019798_ChIP-Seq_JUKART_Human1.01105617
144SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00681113
145SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99623674
146E2F1_18555785_Chip-Seq_ESCs_Mouse0.99238878
147EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98346799
148CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97634473
149SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97302723
150STAT3_23295773_ChIP-Seq_U87_Human0.97220882
151FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97031617
152RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96456549
153TCF7_22412390_ChIP-Seq_EML_Mouse0.96291438
154CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96080441
155GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94755787
156TP63_19390658_ChIP-ChIP_HaCaT_Human0.94341989
157MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.93870939
158PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93671940
159KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93524148
160POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92104037
161IRF8_27001747_Chip-Seq_BMDM_Mouse0.91953354
162P300_18555785_Chip-Seq_ESCs_Mouse0.91800296
163STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91354038
164STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91076278
165BCAT_22108803_ChIP-Seq_LS180_Human0.90747287
166RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.90318317
167RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90198776
168TCF4_23295773_ChIP-Seq_U87_Human0.89884171
169OCT4_18555785_Chip-Seq_ESCs_Mouse0.89039944

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.54576727
2MP0003693_abnormal_embryo_hatching3.28831664
3MP0002396_abnormal_hematopoietic_system3.22942902
4MP0000372_irregular_coat_pigmentation3.05813043
5MP0005084_abnormal_gallbladder_morpholo2.98696427
6MP0008057_abnormal_DNA_replication2.97680001
7MP0003077_abnormal_cell_cycle2.80464172
8MP0003111_abnormal_nucleus_morphology2.72417482
9MP0001835_abnormal_antigen_presentation2.56186805
10MP0005671_abnormal_response_to2.55435156
11MP0004957_abnormal_blastocyst_morpholog2.52036518
12MP0003763_abnormal_thymus_physiology2.44774427
13MP0008058_abnormal_DNA_repair2.37434335
14MP0008007_abnormal_cellular_replicative2.28548779
15MP0006292_abnormal_olfactory_placode2.25795444
16MP0010352_gastrointestinal_tract_polyps2.25125509
17MP0003718_maternal_effect2.17477796
18MP0001800_abnormal_humoral_immune2.14670741
19MP0002398_abnormal_bone_marrow2.14294663
20MP0005645_abnormal_hypothalamus_physiol2.04462022
21MP0000685_abnormal_immune_system1.91712324
22MP0006072_abnormal_retinal_apoptosis1.91052769
23MP0004808_abnormal_hematopoietic_stem1.90114742
24MP0006036_abnormal_mitochondrial_physio1.85215898
25MP0005397_hematopoietic_system_phenotyp1.82763104
26MP0001545_abnormal_hematopoietic_system1.82763104
27MP0002166_altered_tumor_susceptibility1.82402711
28MP0002837_dystrophic_cardiac_calcinosis1.82322865
29MP0002722_abnormal_immune_system1.80443826
30MP0002452_abnormal_antigen_presenting1.79990188
31MP0000703_abnormal_thymus_morphology1.79724476
32MP0008877_abnormal_DNA_methylation1.78879367
33MP0002420_abnormal_adaptive_immunity1.78781889
34MP0004215_abnormal_myocardial_fiber1.78654257
35MP0000689_abnormal_spleen_morphology1.77812523
36MP0002006_tumorigenesis1.77579670
37MP0001819_abnormal_immune_cell1.76920103
38MP0000490_abnormal_crypts_of1.76487095
39MP0009333_abnormal_splenocyte_physiolog1.75780421
40MP0002723_abnormal_immune_serum1.70760242
41MP0010307_abnormal_tumor_latency1.70297597
42MP0000716_abnormal_immune_system1.68396419
43MP0009785_altered_susceptibility_to1.65887647
44MP0005000_abnormal_immune_tolerance1.62964874
45MP0001929_abnormal_gametogenesis1.62717088
46MP0002234_abnormal_pharynx_morphology1.62352656
47MP0003136_yellow_coat_color1.60697341
48MP0002429_abnormal_blood_cell1.59902902
49MP0005551_abnormal_eye_electrophysiolog1.58591038
50MP0008995_early_reproductive_senescence1.57724289
51MP0005646_abnormal_pituitary_gland1.57660079
52MP0002019_abnormal_tumor_incidence1.55249267
53MP0002102_abnormal_ear_morphology1.55118530
54MP0003436_decreased_susceptibility_to1.53792214
55MP0001853_heart_inflammation1.53063485
56MP0001790_abnormal_immune_system1.52844356
57MP0005387_immune_system_phenotype1.52844356
58MP0005174_abnormal_tail_pigmentation1.50987309
59MP0001764_abnormal_homeostasis1.48383111
60MP0002160_abnormal_reproductive_system1.48265407
61MP0006054_spinal_hemorrhage1.48009999
62MP0005025_abnormal_response_to1.47213478
63MP0000350_abnormal_cell_proliferation1.44139319
64MP0006035_abnormal_mitochondrial_morpho1.42844597
65MP0006276_abnormal_autonomic_nervous1.41609822
66MP0002405_respiratory_system_inflammati1.41547298
67MP0010155_abnormal_intestine_physiology1.41008650
68MP0002210_abnormal_sex_determination1.40576200
69MP0001984_abnormal_olfaction1.35010204
70MP0003787_abnormal_imprinting1.32466978
71MP0003698_abnormal_male_reproductive1.30572886
72MP0005464_abnormal_platelet_physiology1.29949292
73MP0003011_delayed_dark_adaptation1.29174277
74MP0002132_abnormal_respiratory_system1.28975901
75MP0000569_abnormal_digit_pigmentation1.28540670
76MP0000653_abnormal_sex_gland1.27019438
77MP0004084_abnormal_cardiac_muscle1.26700246
78MP0008789_abnormal_olfactory_epithelium1.26636672
79MP0003806_abnormal_nucleotide_metabolis1.25857783
80MP0005220_abnormal_exocrine_pancreas1.25355344
81MP0001145_abnormal_male_reproductive1.25248807
82MP0005410_abnormal_fertilization1.24736016
83MP0003724_increased_susceptibility_to1.23380517
84MP0005253_abnormal_eye_physiology1.22717174
85MP0002736_abnormal_nociception_after1.21074679
86MP0002419_abnormal_innate_immunity1.20505480
87MP0001873_stomach_inflammation1.19628547
88MP0003786_premature_aging1.19030981
89MP0001730_embryonic_growth_arrest1.18988727
90MP0008872_abnormal_physiological_respon1.18822756
91MP0000858_altered_metastatic_potential1.18815391
92MP0005389_reproductive_system_phenotype1.18585067
93MP0008775_abnormal_heart_ventricle1.16771012
94MP0002148_abnormal_hypersensitivity_rea1.16014712
95MP0009278_abnormal_bone_marrow1.15456212
96MP0000465_gastrointestinal_hemorrhage1.14976430
97MP0002009_preneoplasia1.13388760
98MP0000313_abnormal_cell_death1.13126877
99MP0001986_abnormal_taste_sensitivity1.12915016
100MP0001529_abnormal_vocalization1.12740407
101MP0004947_skin_inflammation1.10301615
102MP0002877_abnormal_melanocyte_morpholog1.10138408
103MP0001293_anophthalmia1.09384445
104MP0008932_abnormal_embryonic_tissue1.08587197
105MP0001845_abnormal_inflammatory_respons1.08377331
106MP0009697_abnormal_copulation1.06080987
107MP0001697_abnormal_embryo_size1.05866376
108MP0005075_abnormal_melanosome_morpholog1.05772833
109MP0005076_abnormal_cell_differentiation1.03896483
110MP0002086_abnormal_extraembryonic_tissu1.03160927
111MP0003656_abnormal_erythrocyte_physiolo1.03016060
112MP0000631_abnormal_neuroendocrine_gland1.02872230
113MP0000230_abnormal_systemic_arterial1.02125519
114MP0004142_abnormal_muscle_tone1.01840657
115MP0003866_abnormal_defecation0.98808555
116MP0000371_diluted_coat_color0.97694256
117MP0002080_prenatal_lethality0.97312922
118MP0001672_abnormal_embryogenesis/_devel0.97242259
119MP0005380_embryogenesis_phenotype0.97242259
120MP0001119_abnormal_female_reproductive0.97117843
121MP0002822_catalepsy0.94604696
122MP0003186_abnormal_redox_activity0.93486107
123MP0003984_embryonic_growth_retardation0.93275476
124MP0006082_CNS_inflammation0.92018395
125MP0003567_abnormal_fetal_cardiomyocyte0.91843240
126MP0002095_abnormal_skin_pigmentation0.91492092
127MP0002088_abnormal_embryonic_growth/wei0.90774379
128MP0004197_abnormal_fetal_growth/weight/0.88032165
129MP0004043_abnormal_pH_regulation0.87192943
130MP0001324_abnormal_eye_pigmentation0.86747548
131MP0003121_genomic_imprinting0.85777598
132MP0002653_abnormal_ependyma_morphology0.85215103
133MP0005023_abnormal_wound_healing0.85060080
134MP0004147_increased_porphyrin_level0.84925856
135MP0003448_altered_tumor_morphology0.84451830
136MP0003566_abnormal_cell_adhesion0.84245175
137MP0002928_abnormal_bile_duct0.82664477
138MP0002751_abnormal_autonomic_nervous0.82439803
139MP0000358_abnormal_cell_content/0.82037031
140MP0008004_abnormal_stomach_pH0.80691993
141MP0000015_abnormal_ear_pigmentation0.79926571
142MP0005367_renal/urinary_system_phenotyp0.78456436
143MP0000516_abnormal_urinary_system0.78456436
144MP0002638_abnormal_pupillary_reflex0.78253887
145MP0003123_paternal_imprinting0.77954081
146MP0001188_hyperpigmentation0.77923475
147MP0003252_abnormal_bile_duct0.76884117
148MP0003943_abnormal_hepatobiliary_system0.76563046
149MP0008469_abnormal_protein_level0.75852262
150MP0002233_abnormal_nose_morphology0.75404043
151MP0003300_gastrointestinal_ulcer0.73597762
152MP0005171_absent_coat_pigmentation0.73509922
153MP0005310_abnormal_salivary_gland0.72770730
154MP0000477_abnormal_intestine_morphology0.71777432
155MP0002735_abnormal_chemical_nociception0.71453123
156MP0000598_abnormal_liver_morphology0.70205775
157MP0002090_abnormal_vision0.70118068
158MP0002085_abnormal_embryonic_tissue0.69797508
159MP0009765_abnormal_xenobiotic_induced0.69480950
160MP0010234_abnormal_vibrissa_follicle0.69013260
161MP0000647_abnormal_sebaceous_gland0.67458421
162MP0002938_white_spotting0.66554610
163MP0005266_abnormal_metabolism0.66073225

Predicted human phenotypes

RankGene SetZ-score
1Renal cortical cysts (HP:0000803)4.45440848
2IgM deficiency (HP:0002850)4.33512184
3Reticulocytopenia (HP:0001896)3.91794828
4Birth length less than 3rd percentile (HP:0003561)3.88185019
5Pancreatic fibrosis (HP:0100732)3.26642276
6Abnormality of the renal cortex (HP:0011035)3.26122758
7Severe combined immunodeficiency (HP:0004430)3.23722283
8Panhypogammaglobulinemia (HP:0003139)3.20675490
9Thyroiditis (HP:0100646)3.16826089
10Combined immunodeficiency (HP:0005387)3.14818410
1111 pairs of ribs (HP:0000878)3.07281440
12Recurrent viral infections (HP:0004429)3.06033622
13Chromsome breakage (HP:0040012)3.05240158
14Breast hypoplasia (HP:0003187)3.04491944
15Thrombocytosis (HP:0001894)3.03467344
16Abnormality of B cell number (HP:0010975)3.00775968
17B lymphocytopenia (HP:0010976)3.00775968
18Pancreatic cysts (HP:0001737)2.98354670
19Abnormality of T cells (HP:0002843)2.96653760
20Medial flaring of the eyebrow (HP:0010747)2.96280288
21Aplastic anemia (HP:0001915)2.93365632
22IgA deficiency (HP:0002720)2.89604652
23IgG deficiency (HP:0004315)2.88899469
24Myositis (HP:0100614)2.86073518
25Abnormality of T cell physiology (HP:0011840)2.85657171
26T lymphocytopenia (HP:0005403)2.85234167
273-Methylglutaconic aciduria (HP:0003535)2.85200789
28Abnormality of cells of the erythroid lineage (HP:0012130)2.84648595
29Recurrent bronchitis (HP:0002837)2.84074663
30Abnormality of chromosome stability (HP:0003220)2.83374776
31Abnormal number of erythroid precursors (HP:0012131)2.82592567
32True hermaphroditism (HP:0010459)2.76582796
33Myelodysplasia (HP:0002863)2.75945575
34Hypoglycemic coma (HP:0001325)2.75068383
35Abnormality of the fingertips (HP:0001211)2.74171611
36Abnormality of T cell number (HP:0011839)2.73955488
37Colon cancer (HP:0003003)2.72666760
38Hypoplasia of the thymus (HP:0000778)2.69144660
39Hyperglycinemia (HP:0002154)2.66715184
40Lymphoma (HP:0002665)2.62376948
41Chromosomal breakage induced by crosslinking agents (HP:0003221)2.61545496
42Acute myeloid leukemia (HP:0004808)2.61116020
43Renal Fanconi syndrome (HP:0001994)2.56284793
44Amaurosis fugax (HP:0100576)2.55213897
45Recurrent fungal infections (HP:0002841)2.54864620
46Retrobulbar optic neuritis (HP:0100654)2.53572233
47Optic neuritis (HP:0100653)2.53572233
48Increased hepatocellular lipid droplets (HP:0006565)2.53165669
49Generalized aminoaciduria (HP:0002909)2.52164373
50Metaphyseal dysplasia (HP:0100255)2.51026201
51Agnosia (HP:0010524)2.49946654
52Tubulointerstitial nephritis (HP:0001970)2.49896994
53Volvulus (HP:0002580)2.49320310
54Congenital primary aphakia (HP:0007707)2.49200646
55Acute necrotizing encephalopathy (HP:0006965)2.48859636
56Hepatic necrosis (HP:0002605)2.47209107
57Abnormality of macular pigmentation (HP:0008002)2.42630878
58Abnormality of midbrain morphology (HP:0002418)2.42331242
59Molar tooth sign on MRI (HP:0002419)2.42331242
60Decreased central vision (HP:0007663)2.40809889
61Chronic otitis media (HP:0000389)2.40395584
62Abolished electroretinogram (ERG) (HP:0000550)2.39638394
63Abnormal mitochondria in muscle tissue (HP:0008316)2.39576360
64Progressive macrocephaly (HP:0004481)2.37982051
65Syringomyelia (HP:0003396)2.37226657
66Spinal cord lesions (HP:0100561)2.37226657
67Acute encephalopathy (HP:0006846)2.35047076
68Increased mean platelet volume (HP:0011877)2.34616173
69Lipid accumulation in hepatocytes (HP:0006561)2.33143200
70Nephrogenic diabetes insipidus (HP:0009806)2.32951703
71Increased CSF lactate (HP:0002490)2.31158599
72Absent thumb (HP:0009777)2.31081279
73Methylmalonic acidemia (HP:0002912)2.31061122
74Mitochondrial inheritance (HP:0001427)2.30414737
75Orchitis (HP:0100796)2.30355209
76Granulocytopenia (HP:0001913)2.30196964
77Abnormality of the preputium (HP:0100587)2.30083144
78Abnormality of lateral ventricle (HP:0030047)2.28959815
79Gait imbalance (HP:0002141)2.24890095
80Attenuation of retinal blood vessels (HP:0007843)2.23571045
81Abnormality of eosinophils (HP:0001879)2.23445448
82Eosinophilia (HP:0001880)2.21669442
83Oral leukoplakia (HP:0002745)2.21390365
84Selective tooth agenesis (HP:0001592)2.21169277
85Lymphopenia (HP:0001888)2.19870660
86Median cleft lip (HP:0000161)2.18948852
87Aplasia/Hypoplasia of the uvula (HP:0010293)2.18471672
88Decreased activity of mitochondrial respiratory chain (HP:0008972)2.18282036
89Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.18282036
90Abnormality of cells of the lymphoid lineage (HP:0012140)2.15467547
91Recurrent abscess formation (HP:0002722)2.14629251
92Abnormal biliary tract physiology (HP:0012439)2.13811820
93Bile duct proliferation (HP:0001408)2.13811820
94Elevated erythrocyte sedimentation rate (HP:0003565)2.12601563
95Nausea (HP:0002018)2.11955337
96Gonadotropin excess (HP:0000837)2.11190324
97Abnormal platelet volume (HP:0011876)2.10378303
98Abnormality of aspartate family amino acid metabolism (HP:0010899)2.09778092
99Meckel diverticulum (HP:0002245)2.07806389
100Constricted visual fields (HP:0001133)2.07500950
101Basal cell carcinoma (HP:0002671)2.06187589
102Chronic hepatic failure (HP:0100626)2.04733657
103Abnormal glycosylation (HP:0012345)2.04391781
104Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.04391781
105Abnormal protein N-linked glycosylation (HP:0012347)2.04391781
106Abnormal protein glycosylation (HP:0012346)2.04391781
107Encephalitis (HP:0002383)2.01880342
108Bone marrow hypocellularity (HP:0005528)2.00893556
109Mediastinal lymphadenopathy (HP:0100721)2.00701838
110Congenital hepatic fibrosis (HP:0002612)2.00404730
111Abnormality of the prostate (HP:0008775)1.99225363
112Meningitis (HP:0001287)1.98962441
113Pallor (HP:0000980)1.98544280
114Keratoconjunctivitis sicca (HP:0001097)1.97640348
115Abnormality of the ileum (HP:0001549)1.97252935
116Sloping forehead (HP:0000340)1.96978307
117Albinism (HP:0001022)1.96754261
118Leukocytosis (HP:0001974)1.96421334
119Postaxial foot polydactyly (HP:0001830)1.95797518
120Exertional dyspnea (HP:0002875)1.95386370
121Clubbing of toes (HP:0100760)1.95356914
122Nephronophthisis (HP:0000090)1.95205777
123Arterial thrombosis (HP:0004420)1.94826123
124Ependymoma (HP:0002888)1.94701200
125Abnormality of the anterior horn cell (HP:0006802)1.94218913
126Degeneration of anterior horn cells (HP:0002398)1.94218913
127Abnormal delayed hypersensitivity skin test (HP:0002963)1.94094097
128Recurrent sinusitis (HP:0011108)1.92885856
129Type I transferrin isoform profile (HP:0003642)1.92006018
130Pustule (HP:0200039)1.91896372
131Abnormality of the renal medulla (HP:0100957)1.91895428
132Aplasia/Hypoplasia of the tongue (HP:0010295)1.90481321
133Dyschromatopsia (HP:0007641)1.90418861
134Recurrent bacterial skin infections (HP:0005406)1.89704598
135Hepatocellular necrosis (HP:0001404)1.89272247
136Patellar aplasia (HP:0006443)1.88019316
137Petechiae (HP:0000967)1.87447847
138Abnormality of reticulocytes (HP:0004312)1.86853693
139Leukopenia (HP:0001882)1.85674638
140Abnormality of urine glucose concentration (HP:0011016)1.85114409
141Glycosuria (HP:0003076)1.85114409
142Abnormality of DNA repair (HP:0003254)1.84964688
143Prominent nose (HP:0000448)1.83369490
144Proximal placement of thumb (HP:0009623)1.83272808
145Eczematoid dermatitis (HP:0000976)1.82932123
146Deviation of the thumb (HP:0009603)1.82828845
147Nasal polyposis (HP:0100582)1.82590104
148High pitched voice (HP:0001620)1.82425725
149Hypoproteinemia (HP:0003075)1.82419987
150Genital tract atresia (HP:0001827)1.81656261
151Short tibia (HP:0005736)1.81315117
152Male pseudohermaphroditism (HP:0000037)1.79896304
153Small intestinal stenosis (HP:0012848)1.78798870
154Duodenal stenosis (HP:0100867)1.78798870
155Choroideremia (HP:0001139)1.78379331
156Cellulitis (HP:0100658)1.78356974
157Congenital, generalized hypertrichosis (HP:0004540)1.77622218
158Abnormality of pyrimidine metabolism (HP:0004353)1.77366528
159Abnormality of methionine metabolism (HP:0010901)1.76672244
160Keratoconjunctivitis (HP:0001096)1.76432534
161Abnormal ciliary motility (HP:0012262)1.75671574
162Autoimmune thrombocytopenia (HP:0001973)1.75605943
163Medulloblastoma (HP:0002885)1.75600736
164Abnormality of the heme biosynthetic pathway (HP:0010472)1.75465165
165Abnormality of the duodenum (HP:0002246)1.75445442
166Agammaglobulinemia (HP:0004432)1.74830343
167Epistaxis (HP:0000421)1.74392282
168Increased intramyocellular lipid droplets (HP:0012240)1.74005805
169Aplasia/Hypoplasia of the tibia (HP:0005772)1.73856307
170Abnormality of the labia minora (HP:0012880)1.73531719
171Poikiloderma (HP:0001029)1.73171136
172Atrophy/Degeneration involving motor neurons (HP:0007373)1.73120630
173Pancreatic islet-cell hyperplasia (HP:0004510)1.71528389
174Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.71410064
175Abnormality of the fovea (HP:0000493)1.70857992
176Prolonged bleeding time (HP:0003010)1.70039396
177Abnormal spermatogenesis (HP:0008669)1.69843092
178Lactic acidosis (HP:0003128)1.69744339
179Reduced antithrombin III activity (HP:0001976)1.69167236
180Increased serum lactate (HP:0002151)1.68614560

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.74255489
2MAP4K23.39828734
3MAP4K13.13371441
4FRK2.69090121
5WEE12.55908937
6FLT32.52899908
7JAK32.41953189
8NME22.28520541
9TRIM282.23495572
10EIF2AK12.20211404
11NUAK12.10646737
12VRK22.09862920
13ACVR1B2.05935386
14TSSK62.03605203
15BTK2.00544117
16BMPR1B1.96444967
17NEK21.93574262
18ERBB31.87094370
19PASK1.85679074
20MAP3K41.81801483
21TXK1.81390039
22PNCK1.77240192
23STK101.76530170
24TGFBR11.75539929
25TGFBR21.69770959
26ATR1.66143566
27BUB11.64477993
28WNK31.60999085
29KIT1.59299418
30TEC1.58818537
31STK161.58181418
32PIM11.55996544
33MUSK1.55073577
34SRPK11.54303988
35CDK121.51437933
36TYK21.49601383
37INSRR1.49154455
38VRK11.47655376
39MAP3K141.47538437
40CDK41.41992326
41ITK1.41582188
42PKN21.41434818
43BCKDK1.39134408
44BRSK21.37945219
45STK41.37093707
46CDK71.35609852
47ZAP701.34518225
48PLK21.31873995
49GRK61.27894425
50BMPR21.27085530
51AURKB1.26828641
52RPS6KB21.17939410
53ADRBK21.17617784
54EEF2K1.17192353
55PLK11.17097727
56EIF2AK31.15025708
57CDK191.14880219
58PLK41.14566245
59CSF1R1.12607730
60PIK3CG1.11995750
61MKNK21.09883288
62NEK11.08641575
63SYK1.08179832
64TTK1.07288079
65OXSR11.04457038
66IKBKB1.02927952
67RPS6KA41.01744767
68GRK11.00111021
69CHEK20.99933443
70TNIK0.99557490
71MELK0.97368769
72MAPK130.95628039
73NEK90.93785549
74MAP3K80.90560369
75CHUK0.90219774
76ZAK0.88508300
77TAF10.86566035
78LCK0.86539412
79ATM0.85554229
80PLK30.85050647
81CDK60.84745821
82RAF10.84715350
83TESK20.84619340
84LYN0.83901398
85LRRK20.82956287
86DYRK20.82574523
87TLK10.80975929
88STK390.79776227
89IRAK40.79484811
90PIM20.78830162
91CHEK10.78629829
92MARK30.78510400
93MAP2K70.77778256
94STK30.77742634
95MKNK10.77509181
96CSNK1G30.77325535
97TAOK30.76632448
98JAK10.76163494
99CSNK1G10.75668362
100SCYL20.75568488
101FES0.73408869
102PBK0.72488009
103CSNK1G20.72466651
104MAP3K100.72450886
105PRKD30.70030370
106CCNB10.69661443
107CDK80.69133240
108PRKCE0.68662269
109MINK10.66980206
110TBK10.65451546
111IKBKE0.65124227
112EIF2AK20.62590596
113BCR0.62583096
114DAPK10.61273076
115DYRK30.60054327
116CDK20.59975355
117MAPKAPK30.58356210
118JAK20.57846381
119NLK0.57429366
120ADRBK10.56587887
121CDK90.56328396
122LATS10.56254351
123BRD40.55497973
124MAP3K50.55399440
125PINK10.53853957
126CSK0.53366166
127CLK10.52795911
128GRK50.51088015
129RPS6KB10.51020760
130RPS6KA60.50798289
131HCK0.50401177
132BRSK10.48231321
133MST40.47409352
134IRAK30.46782195
135ILK0.46016313
136CDK30.45851615
137PTK60.45679295
138RPS6KL10.45591697
139RPS6KC10.45591697
140TRPM70.45499534
141CSNK2A20.43115545
142MAPK110.42305403
143MAP3K120.41089032
144CASK0.39389293
145AURKA0.39313477
146CSNK1A1L0.39058389
147DAPK30.37937666
148RPS6KA50.36753133
149PRKCQ0.35350186
150CSNK2A10.34664895

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.53424360
2Mismatch repair_Homo sapiens_hsa034303.86871636
3Non-homologous end-joining_Homo sapiens_hsa034502.89921940
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.87668188
5Base excision repair_Homo sapiens_hsa034102.87073004
6Homologous recombination_Homo sapiens_hsa034402.86916699
7Primary immunodeficiency_Homo sapiens_hsa053402.76745287
8Ribosome_Homo sapiens_hsa030102.56985275
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.40801490
10Nucleotide excision repair_Homo sapiens_hsa034202.32619395
11Cell cycle_Homo sapiens_hsa041102.30061490
12Spliceosome_Homo sapiens_hsa030402.28936645
13Propanoate metabolism_Homo sapiens_hsa006402.25074669
14Fatty acid elongation_Homo sapiens_hsa000622.17518274
15RNA transport_Homo sapiens_hsa030132.16349825
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.06532036
17RNA polymerase_Homo sapiens_hsa030201.95414745
18Pyrimidine metabolism_Homo sapiens_hsa002401.93367604
19One carbon pool by folate_Homo sapiens_hsa006701.90254487
20Antigen processing and presentation_Homo sapiens_hsa046121.87754139
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83354798
22Fanconi anemia pathway_Homo sapiens_hsa034601.82853656
23Butanoate metabolism_Homo sapiens_hsa006501.79227367
24Oxidative phosphorylation_Homo sapiens_hsa001901.78720852
25Parkinsons disease_Homo sapiens_hsa050121.73722374
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73170392
27RNA degradation_Homo sapiens_hsa030181.72337680
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.69609727
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.60763764
30p53 signaling pathway_Homo sapiens_hsa041151.54373706
31Peroxisome_Homo sapiens_hsa041461.53889640
32Type I diabetes mellitus_Homo sapiens_hsa049401.51724321
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.49383700
34Proteasome_Homo sapiens_hsa030501.48143286
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.44700134
36Herpes simplex infection_Homo sapiens_hsa051681.43150454
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.42257957
38Nitrogen metabolism_Homo sapiens_hsa009101.42146007
39NF-kappa B signaling pathway_Homo sapiens_hsa040641.38273726
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.38203331
41Measles_Homo sapiens_hsa051621.36989942
42Basal transcription factors_Homo sapiens_hsa030221.33112593
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29639154
44Phototransduction_Homo sapiens_hsa047441.26505286
45B cell receptor signaling pathway_Homo sapiens_hsa046621.18665963
46mRNA surveillance pathway_Homo sapiens_hsa030151.17480457
47Huntingtons disease_Homo sapiens_hsa050161.09011195
48Hematopoietic cell lineage_Homo sapiens_hsa046401.08373907
49Allograft rejection_Homo sapiens_hsa053301.07666187
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.07560173
51Regulation of autophagy_Homo sapiens_hsa041401.07437598
52Graft-versus-host disease_Homo sapiens_hsa053321.04355090
53Epstein-Barr virus infection_Homo sapiens_hsa051691.04033993
54Glutathione metabolism_Homo sapiens_hsa004801.03263258
55T cell receptor signaling pathway_Homo sapiens_hsa046601.02759041
56Leishmaniasis_Homo sapiens_hsa051401.01569476
57Viral carcinogenesis_Homo sapiens_hsa052031.00100038
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.96944921
59Oocyte meiosis_Homo sapiens_hsa041140.95754988
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93274066
61Legionellosis_Homo sapiens_hsa051340.92492800
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91793126
63Systemic lupus erythematosus_Homo sapiens_hsa053220.90557445
64Selenocompound metabolism_Homo sapiens_hsa004500.90300206
65HTLV-I infection_Homo sapiens_hsa051660.90270816
66Platelet activation_Homo sapiens_hsa046110.89898052
67Olfactory transduction_Homo sapiens_hsa047400.89660553
68Acute myeloid leukemia_Homo sapiens_hsa052210.89090466
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87774511
70Purine metabolism_Homo sapiens_hsa002300.86275661
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85409526
72Protein export_Homo sapiens_hsa030600.81280219
73Hepatitis B_Homo sapiens_hsa051610.80339558
74Chronic myeloid leukemia_Homo sapiens_hsa052200.79773796
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78741021
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78144904
77Thyroid cancer_Homo sapiens_hsa052160.77134731
78beta-Alanine metabolism_Homo sapiens_hsa004100.76746822
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.75848094
80Apoptosis_Homo sapiens_hsa042100.75800710
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.75691009
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72838200
83Alzheimers disease_Homo sapiens_hsa050100.72314013
84Pentose phosphate pathway_Homo sapiens_hsa000300.69592855
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68705674
86Small cell lung cancer_Homo sapiens_hsa052220.68613155
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.68137210
88Influenza A_Homo sapiens_hsa051640.67783246
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67778601
90Caffeine metabolism_Homo sapiens_hsa002320.67088636
91Fatty acid metabolism_Homo sapiens_hsa012120.65242167
92MicroRNAs in cancer_Homo sapiens_hsa052060.64167841
93Alcoholism_Homo sapiens_hsa050340.63615857
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61588627
95Folate biosynthesis_Homo sapiens_hsa007900.61062973
96Arachidonic acid metabolism_Homo sapiens_hsa005900.60516750
97Pancreatic cancer_Homo sapiens_hsa052120.60210435
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59141196
99Osteoclast differentiation_Homo sapiens_hsa043800.58751109
100Viral myocarditis_Homo sapiens_hsa054160.58702045
101Toxoplasmosis_Homo sapiens_hsa051450.58590785
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58398921
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.57738911
104Colorectal cancer_Homo sapiens_hsa052100.57373209
105Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56469114
106Metabolic pathways_Homo sapiens_hsa011000.55047380
107Lysine degradation_Homo sapiens_hsa003100.54471073
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53192730
109Chemical carcinogenesis_Homo sapiens_hsa052040.53166655
110Linoleic acid metabolism_Homo sapiens_hsa005910.53109689
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52424499
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51483697
113Collecting duct acid secretion_Homo sapiens_hsa049660.51414599
114Tryptophan metabolism_Homo sapiens_hsa003800.51371622
115Staphylococcus aureus infection_Homo sapiens_hsa051500.51182500
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50057964
117Shigellosis_Homo sapiens_hsa051310.49755654
118Cyanoamino acid metabolism_Homo sapiens_hsa004600.49487682
119Non-small cell lung cancer_Homo sapiens_hsa052230.48661051
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47694694
121N-Glycan biosynthesis_Homo sapiens_hsa005100.47648439
122Galactose metabolism_Homo sapiens_hsa000520.47481227
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47410869
124Autoimmune thyroid disease_Homo sapiens_hsa053200.46144415
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.45929452
126alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45631786
127Sulfur metabolism_Homo sapiens_hsa009200.44865637
128Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43488856
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43214387
130Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43064556
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42140891
132Pyruvate metabolism_Homo sapiens_hsa006200.42123315
133Fatty acid degradation_Homo sapiens_hsa000710.42096607
134Asthma_Homo sapiens_hsa053100.41184482
135TNF signaling pathway_Homo sapiens_hsa046680.40772985
136Cysteine and methionine metabolism_Homo sapiens_hsa002700.40216997
137Malaria_Homo sapiens_hsa051440.38345346
138Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37128793
139Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36261805
140Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34266271
141Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34188153
142Rheumatoid arthritis_Homo sapiens_hsa053230.31111170
143Biosynthesis of amino acids_Homo sapiens_hsa012300.30647381
144Prostate cancer_Homo sapiens_hsa052150.30545946
145Other glycan degradation_Homo sapiens_hsa005110.30266654
146Serotonergic synapse_Homo sapiens_hsa047260.28851984
147Central carbon metabolism in cancer_Homo sapiens_hsa052300.27198469
148mTOR signaling pathway_Homo sapiens_hsa041500.27093782
149Steroid biosynthesis_Homo sapiens_hsa001000.26838203
150Retinol metabolism_Homo sapiens_hsa008300.24790661
151Pathways in cancer_Homo sapiens_hsa052000.24632729
152FoxO signaling pathway_Homo sapiens_hsa040680.23564068
153Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23177767
154Notch signaling pathway_Homo sapiens_hsa043300.22416191

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