PRKAA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)8.05707621
2COPI coating of Golgi vesicle (GO:0048205)8.05707621
3retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.70596126
4negative regulation of complement activation (GO:0045916)4.64620084
5activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.63709397
6maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.61172723
7protein maturation by protein folding (GO:0022417)4.59928869
8positive regulation of nuclease activity (GO:0032075)4.56369551
9negative regulation of protein activation cascade (GO:2000258)4.44558397
10UDP-N-acetylglucosamine metabolic process (GO:0006047)4.34506640
11sequestering of metal ion (GO:0051238)4.27201263
12regulation of nuclease activity (GO:0032069)4.21996100
13endoplasmic reticulum unfolded protein response (GO:0030968)4.15087676
14COPII vesicle coating (GO:0048208)4.10948403
15hypotonic response (GO:0006971)4.10004644
16negative regulation of humoral immune response (GO:0002921)4.01281704
17cellular response to unfolded protein (GO:0034620)3.96902192
18vesicle coating (GO:0006901)3.86938018
19protein retention in ER lumen (GO:0006621)3.86158250
20ER-nucleus signaling pathway (GO:0006984)3.78980610
21protein localization to endosome (GO:0036010)3.73200718
22cellular response to topologically incorrect protein (GO:0035967)3.71230382
23embryonic process involved in female pregnancy (GO:0060136)3.68920859
24definitive hemopoiesis (GO:0060216)3.47731377
25cellular response to vitamin D (GO:0071305)3.35780806
26folic acid-containing compound biosynthetic process (GO:0009396)3.28960183
27cellular response to vitamin (GO:0071295)3.27657441
28hepatocyte apoptotic process (GO:0097284)3.24094878
29response to endoplasmic reticulum stress (GO:0034976)3.17989634
30response to unfolded protein (GO:0006986)3.14298887
31regulation of complement activation (GO:0030449)3.11406744
32positive regulation of histone deacetylation (GO:0031065)3.11285709
33regulation of translational termination (GO:0006449)3.11034767
34negative regulation of fatty acid transport (GO:2000192)3.08810835
35phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.08781241
36hepatocyte differentiation (GO:0070365)3.07962731
37* histone-serine phosphorylation (GO:0035404)3.06963137
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.04721544
39interleukin-6-mediated signaling pathway (GO:0070102)3.03980751
40Golgi organization (GO:0007030)3.02455925
41cell adhesion mediated by integrin (GO:0033627)3.01687061
42low-density lipoprotein particle clearance (GO:0034383)3.00107840
43regulation of protein activation cascade (GO:2000257)3.00030415
44nuclear pore complex assembly (GO:0051292)2.99704643
45protein localization to kinetochore (GO:0034501)2.98930580
46regulation of type B pancreatic cell apoptotic process (GO:2000674)2.96299987
47nuclear pore organization (GO:0006999)2.95955754
48regulation of spindle organization (GO:0090224)2.92720018
49response to topologically incorrect protein (GO:0035966)2.92640371
50negative regulation of glycoprotein biosynthetic process (GO:0010561)2.88588682
51desmosome organization (GO:0002934)2.88040408
52localization within membrane (GO:0051668)2.85294965
53ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.83137497
54iron ion import (GO:0097286)2.83057759
55ER to Golgi vesicle-mediated transport (GO:0006888)2.80126834
56negative regulation of protein localization to plasma membrane (GO:1903077)2.77645073
57membrane budding (GO:0006900)2.77486211
58vascular endothelial growth factor signaling pathway (GO:0038084)2.74887346
59necroptotic process (GO:0070266)2.74369468
60regulation of metalloenzyme activity (GO:0048552)2.74188800
61glucocorticoid receptor signaling pathway (GO:0042921)2.73752616
62type B pancreatic cell development (GO:0003323)2.73748973
63peptidyl-lysine dimethylation (GO:0018027)2.73582949
64regulation of mitotic spindle organization (GO:0060236)2.73030332
65import into cell (GO:0098657)2.71386195
66membrane raft organization (GO:0031579)2.69053139
67peptidyl-proline hydroxylation (GO:0019511)2.67379541
68regulation of transforming growth factor beta1 production (GO:0032908)2.66906586
69protein hydroxylation (GO:0018126)2.65560940
70antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.64641354
71antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.64641354
72peptidyl-asparagine modification (GO:0018196)2.64532101
73regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.63827800
74protein N-linked glycosylation via asparagine (GO:0018279)2.63420850
75nerve growth factor signaling pathway (GO:0038180)2.62872084
76mesodermal cell differentiation (GO:0048333)2.61241199
77nuclear envelope disassembly (GO:0051081)2.61180897
78membrane disassembly (GO:0030397)2.61180897
79monoubiquitinated protein deubiquitination (GO:0035520)2.60840555
80ER overload response (GO:0006983)2.60568771
81apoptotic cell clearance (GO:0043277)2.60448181
82cortical actin cytoskeleton organization (GO:0030866)2.59963653
83regulation of transforming growth factor beta2 production (GO:0032909)2.58169549
84regulation of histone H3-K27 methylation (GO:0061085)2.57323743
85skin morphogenesis (GO:0043589)2.56661274
86cellular extravasation (GO:0045123)2.56474428
87mitotic sister chromatid cohesion (GO:0007064)2.56186279
88positive regulation of protein deacetylation (GO:0090312)2.56137366
89protein autoprocessing (GO:0016540)2.54183653
90growth hormone receptor signaling pathway (GO:0060396)2.53644446
91pore complex assembly (GO:0046931)2.53126095
92positive regulation of glycoprotein metabolic process (GO:1903020)2.52643112
93peptide hormone processing (GO:0016486)2.52027592
94pathway-restricted SMAD protein phosphorylation (GO:0060389)2.51561596
95mitotic nuclear envelope disassembly (GO:0007077)2.51365306
96diterpenoid biosynthetic process (GO:0016102)2.51233321
97cellular response to arsenic-containing substance (GO:0071243)2.51149025
98spindle assembly involved in mitosis (GO:0090307)2.51066561
99regulation of necroptotic process (GO:0060544)2.49259891
100NLS-bearing protein import into nucleus (GO:0006607)2.48833379
101cytoplasmic mRNA processing body assembly (GO:0033962)2.48481215
102positive regulation of osteoblast proliferation (GO:0033690)2.46388415
103early endosome to late endosome transport (GO:0045022)2.45896612
104toxin metabolic process (GO:0009404)2.45364174
105membrane protein ectodomain proteolysis (GO:0006509)2.43885958
106microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.43516412
107response to growth hormone (GO:0060416)2.42970434
108collagen fibril organization (GO:0030199)2.42894635
109intra-Golgi vesicle-mediated transport (GO:0006891)2.42828241
110plasma membrane repair (GO:0001778)2.42085221
111macroautophagy (GO:0016236)2.42031647
112chaperone mediated protein folding requiring cofactor (GO:0051085)2.41725024
113histone H2A monoubiquitination (GO:0035518)2.41134246
114positive regulation of protein import into nucleus, translocation (GO:0033160)2.40921913
115nuclear envelope organization (GO:0006998)2.40167786
116corticosteroid receptor signaling pathway (GO:0031958)2.39748092
117regulation of transforming growth factor beta production (GO:0071634)2.39493196
118sister chromatid segregation (GO:0000819)2.38592531
119IMP metabolic process (GO:0046040)2.38420018
120regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.38181643
121response to lipoprotein particle (GO:0055094)2.37920796
122cytokinetic process (GO:0032506)2.37134830
123negative regulation of anoikis (GO:2000811)2.35529270
124positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.34562381
125regulation of early endosome to late endosome transport (GO:2000641)2.34075168
126protein N-linked glycosylation (GO:0006487)2.32926442
127regulation of anoikis (GO:2000209)2.32624708
128glandular epithelial cell development (GO:0002068)2.32602264
129purine nucleotide salvage (GO:0032261)2.32467130
130negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.31881134
131negative regulation of bone resorption (GO:0045779)2.31337182
132positive regulation of receptor recycling (GO:0001921)2.31206092
133regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.31190231
134sequestering of extracellular ligand from receptor (GO:0035581)2.31050852
135IMP biosynthetic process (GO:0006188)2.30981910
136cellular response to growth hormone stimulus (GO:0071378)2.30709792
137endocrine pancreas development (GO:0031018)2.30114169
138nucleotide-sugar biosynthetic process (GO:0009226)2.29695663
139positive regulation of protein localization to plasma membrane (GO:1903078)2.29319890
1404-hydroxyproline metabolic process (GO:0019471)2.29253439
141protein targeting to lysosome (GO:0006622)2.29004266
142establishment of protein localization to vacuole (GO:0072666)2.29004266
143protein targeting to vacuole (GO:0006623)2.29004266
144protein localization to chromosome, centromeric region (GO:0071459)2.28467732
145positive regulation of transforming growth factor beta production (GO:0071636)2.28155927
146positive regulation of chromosome segregation (GO:0051984)2.28154979
147pericardium development (GO:0060039)2.27367996
148negative regulation of fibrinolysis (GO:0051918)2.22904327
149positive regulation of granulocyte differentiation (GO:0030854)2.22523803
150regulation of RNA export from nucleus (GO:0046831)2.22514834
151retina vasculature morphogenesis in camera-type eye (GO:0061299)2.22179415
152interkinetic nuclear migration (GO:0022027)2.21761882
153urea cycle (GO:0000050)2.20523195
154response to laminar fluid shear stress (GO:0034616)2.19304148
155cell-substrate junction assembly (GO:0007044)2.17992743
156regulation of integrin activation (GO:0033623)2.16706186
157phospholipid translocation (GO:0045332)2.15540250
158lipid translocation (GO:0034204)2.15540250
159urea metabolic process (GO:0019627)2.15351735
160detection of molecule of bacterial origin (GO:0032490)2.15076264
161regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.14884108
162mannose metabolic process (GO:0006013)2.14383891
163positive regulation of hemostasis (GO:1900048)2.14367986
164positive regulation of blood coagulation (GO:0030194)2.14367986
165midgut development (GO:0007494)2.11002773
166regulation of nucleobase-containing compound transport (GO:0032239)2.10193773
167actin filament depolymerization (GO:0030042)2.08006483
168positive regulation of gamma-delta T cell activation (GO:0046645)2.06185131
169programmed necrotic cell death (GO:0097300)2.05624591
170positive regulation of coagulation (GO:0050820)2.03821398
171thrombin receptor signaling pathway (GO:0070493)2.03200943
172necrotic cell death (GO:0070265)2.02833450
173positive regulation of macrophage differentiation (GO:0045651)2.02668543
174hemidesmosome assembly (GO:0031581)2.01625286
175establishment of endothelial barrier (GO:0061028)2.01229993
176regulation of protein localization to plasma membrane (GO:1903076)2.01142426
177Golgi to endosome transport (GO:0006895)2.00212601
178response to interleukin-15 (GO:0070672)1.99053193
179negative regulation of cell killing (GO:0031342)1.99021864
180negative regulation of leukocyte mediated cytotoxicity (GO:0001911)1.99021864
181regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00431.98650940

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.13002446
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.36920164
3E2F7_22180533_ChIP-Seq_HELA_Human3.83978734
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.58936065
5SMAD_19615063_ChIP-ChIP_OVARY_Human3.53325990
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.02130085
7GATA1_22025678_ChIP-Seq_K562_Human2.66823124
8CLOCK_20551151_ChIP-Seq_293T_Human2.58814200
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.33886962
10AR_21909140_ChIP-Seq_LNCAP_Human2.30281530
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.30184265
12GATA2_21666600_ChIP-Seq_HMVEC_Human2.19926095
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.14949577
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.13177930
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.12889012
16TFEB_21752829_ChIP-Seq_HELA_Human2.10004546
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.04522782
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.01866847
19ZNF217_24962896_ChIP-Seq_MCF-7_Human1.98862697
20ESR1_20079471_ChIP-ChIP_T-47D_Human1.98496198
21SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.94680668
22SALL1_21062744_ChIP-ChIP_HESCs_Human1.90294630
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.80477411
24MYC_22102868_ChIP-Seq_BL_Human1.79239949
25* ELK1_19687146_ChIP-ChIP_HELA_Human1.78582851
26IRF8_22096565_ChIP-ChIP_GC-B_Human1.77148895
27FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.76142753
28ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.75051210
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.71186545
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.70814545
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.67143261
32* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.66176583
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63826022
34* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.60959557
35* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.60959557
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59998000
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.59426385
38KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57456452
39ZNF263_19887448_ChIP-Seq_K562_Human1.56642340
40LXR_22158963_ChIP-Seq_LIVER_Mouse1.56157168
41IRF8_27001747_Chip-Seq_BMDM_Mouse1.56008324
42FOXM1_26456572_ChIP-Seq_MCF-7_Human1.55214860
43ATF3_27146783_Chip-Seq_COLON_Human1.53940728
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51713189
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.51259688
46CJUN_26792858_Chip-Seq_BT549_Human1.50676940
47CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.48265869
48FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.46596039
49BRD4_25478319_ChIP-Seq_HGPS_Human1.45851047
50PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.45800005
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45191123
52NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.44379601
53FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.44218017
54ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.42331728
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42328540
56NELFA_20434984_ChIP-Seq_ESCs_Mouse1.41812935
57MYC_18555785_ChIP-Seq_MESCs_Mouse1.40369831
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.40279526
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.39555090
60CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.39221018
61KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39050294
62* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38782369
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38712219
64RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.37888043
65* GATA4_25053715_ChIP-Seq_YYC3_Human1.35848291
66* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.35846596
67CHD1_26751641_Chip-Seq_LNCaP_Human1.35409776
68SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.34548023
69SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.34548023
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.34353187
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33941146
72RUNX_20019798_ChIP-Seq_JUKART_Human1.33903543
73FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.33396163
74IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33219004
75FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.33137533
76BRD4_27068464_Chip-Seq_AML-cells_Mouse1.33026699
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31934595
78MYB_26560356_Chip-Seq_TH2_Human1.30790485
79AHR_22903824_ChIP-Seq_MCF-7_Human1.30372563
80ELK3_25401928_ChIP-Seq_HUVEC_Human1.30324291
81* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.30230460
82FOXO3_23340844_ChIP-Seq_DLD1_Human1.29735967
83ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.29639565
84ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29262708
85SOX9_24532713_ChIP-Seq_HFSC_Mouse1.28769659
86* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28083986
87SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27707035
88* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26358576
89RXR_22158963_ChIP-Seq_LIVER_Mouse1.26130420
90SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24922739
91GATA3_27048872_Chip-Seq_THYMUS_Human1.23822917
92FOXA2_19822575_ChIP-Seq_HepG2_Human1.23722926
93AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.23609472
94ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.23032035
95SALL4_18804426_ChIP-ChIP_XEN_Mouse1.22801682
96FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.21528762
97TCF4_18268006_ChIP-ChIP_LS174T_Human1.19962841
98WT1_19549856_ChIP-ChIP_CCG9911_Human1.19772190
99CREB1_15753290_ChIP-ChIP_HEK293T_Human1.17694977
100TP63_23658742_ChIP-Seq_EP156T_Human1.17170942
101NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.16665563
102VDR_23849224_ChIP-Seq_CD4+_Human1.15772067
103MAF_26560356_Chip-Seq_TH1_Human1.15293971
104MYB_26560356_Chip-Seq_TH1_Human1.14902907
105* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14577710
106NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14333836
107GABP_17652178_ChIP-ChIP_JURKAT_Human1.14329759
108* SPI1_23547873_ChIP-Seq_NB4_Human1.14260362
109KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12202955
110SPI1_23127762_ChIP-Seq_K562_Human1.11813658
111EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.11286665
112GATA6_25053715_ChIP-Seq_YYC3_Human1.11246664
113* FOXA1_25552417_ChIP-Seq_VCAP_Human1.10905088
114PPARA_22158963_ChIP-Seq_LIVER_Mouse1.10652237
115* GATA2_19941826_ChIP-Seq_K562_Human1.10550105
116PU_27001747_Chip-Seq_BMDM_Mouse1.09610875
117CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08993132
118KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08424400
119GATA1_19941826_ChIP-Seq_K562_Human1.07918380
120ARNT_22903824_ChIP-Seq_MCF-7_Human1.07724916
121* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07378385
122STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.06396100
123SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06189947
124PIAS1_25552417_ChIP-Seq_VCAP_Human1.06128449
125GATA3_24758297_ChIP-Seq_MCF-7_Human1.05762965
126VDR_21846776_ChIP-Seq_THP-1_Human1.05625698
127PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05199932
128CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05192841
129AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04941849
130* NCOR1_26117541_ChIP-Seq_K562_Human1.04896198
131EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04886921
132UBF1/2_26484160_Chip-Seq_HMECs_Human1.04859236
133* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04514856
134CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04093940
135SOX2_20726797_ChIP-Seq_SW620_Human1.03493038
136PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03166604
137TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03137558
138MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02721556
139FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02106629
140ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01995429
141STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.01677610
142JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01634857
143* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.01367125
144DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01023299
145UTX_26944678_Chip-Seq_JUKART_Human1.00999417
146ELK1_22589737_ChIP-Seq_MCF10A_Human1.00935548
147JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00711557
148PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00526422
149* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00421848
150* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99619918
151IRF8_21731497_ChIP-ChIP_J774_Mouse0.99515303
152KDM5A_27292631_Chip-Seq_BREAST_Human0.98837708
153TP53_16413492_ChIP-PET_HCT116_Human0.97507863
154CDX2_20551321_ChIP-Seq_CACO-2_Human0.97196474
155SCL_19346495_ChIP-Seq_HPC-7_Human0.95334215

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog4.69761947
2MP0008438_abnormal_cutaneous_collagen3.58617689
3MP0000013_abnormal_adipose_tissue3.07739350
4MP0002009_preneoplasia3.01538016
5MP0003300_gastrointestinal_ulcer2.98499553
6MP0006054_spinal_hemorrhage2.95093496
7MP0003705_abnormal_hypodermis_morpholog2.83220592
8MP0005058_abnormal_lysosome_morphology2.48451517
9MP0010352_gastrointestinal_tract_polyps2.41443384
10MP0003950_abnormal_plasma_membrane2.25468418
11MP0003693_abnormal_embryo_hatching2.23670648
12MP0003566_abnormal_cell_adhesion2.20856983
13MP0005275_abnormal_skin_tensile2.11123688
14MP0010234_abnormal_vibrissa_follicle2.07122197
15MP0010307_abnormal_tumor_latency2.05876953
16MP0003279_aneurysm2.00230401
17MP0000003_abnormal_adipose_tissue1.94245988
18MP0003191_abnormal_cellular_cholesterol1.92805409
19MP0002909_abnormal_adrenal_gland1.92299929
20MP0005076_abnormal_cell_differentiation1.92177051
21MP0000569_abnormal_digit_pigmentation1.83085435
22MP0003724_increased_susceptibility_to1.78202445
23MP0003172_abnormal_lysosome_physiology1.72251012
24MP0004185_abnormal_adipocyte_glucose1.65887554
25MP0005464_abnormal_platelet_physiology1.64085246
26MP0003091_abnormal_cell_migration1.61589461
27MP0003828_pulmonary_edema1.61404670
28MP0001299_abnormal_eye_distance/1.59856455
29MP0003123_paternal_imprinting1.57016203
30MP0001944_abnormal_pancreas_morphology1.52512252
31MP0003183_abnormal_peptide_metabolism1.49693572
32MP0003763_abnormal_thymus_physiology1.47204067
33MP0005023_abnormal_wound_healing1.46407028
34MP0004272_abnormal_basement_membrane1.45707525
35MP0002693_abnormal_pancreas_physiology1.42920877
36MP0002896_abnormal_bone_mineralization1.41514926
37MP0004264_abnormal_extraembryonic_tissu1.39908106
38MP0009780_abnormal_chondrocyte_physiolo1.39617079
39MP0003283_abnormal_digestive_organ1.39230237
40* MP0003656_abnormal_erythrocyte_physiolo1.38695243
41MP0010368_abnormal_lymphatic_system1.38611621
42MP0005623_abnormal_meninges_morphology1.38277422
43MP0003252_abnormal_bile_duct1.37374997
44MP0008057_abnormal_DNA_replication1.36560481
45MP0005085_abnormal_gallbladder_physiolo1.36102008
46MP0000733_abnormal_muscle_development1.29591084
47MP0005164_abnormal_response_to1.29397583
48MP0010678_abnormal_skin_adnexa1.29081233
49MP0002166_altered_tumor_susceptibility1.28680085
50MP0001851_eye_inflammation1.28139911
51MP0005375_adipose_tissue_phenotype1.26317632
52MP0004957_abnormal_blastocyst_morpholog1.25018124
53MP0001730_embryonic_growth_arrest1.22428026
54MP0001958_emphysema1.22373204
55MP0004947_skin_inflammation1.21975911
56MP0003303_peritoneal_inflammation1.17368428
57MP0002396_abnormal_hematopoietic_system1.16100711
58MP0003868_abnormal_feces_composition1.14779881
59MP0004782_abnormal_surfactant_physiolog1.14288982
60MP0010155_abnormal_intestine_physiology1.14186032
61MP0002060_abnormal_skin_morphology1.09077474
62MP0001533_abnormal_skeleton_physiology1.08516332
63* MP0004808_abnormal_hematopoietic_stem1.07344070
64MP0005408_hypopigmentation1.07149048
65MP0003045_fibrosis1.06802753
66MP0005360_urolithiasis1.04515443
67MP0000767_abnormal_smooth_muscle1.03257782
68MP0005220_abnormal_exocrine_pancreas1.03143889
69MP0001835_abnormal_antigen_presentation1.02909892
70MP0004883_abnormal_blood_vessel1.02240969
71MP0004233_abnormal_muscle_weight1.00766109
72MP0000750_abnormal_muscle_regeneration1.00351644
73MP0005503_abnormal_tendon_morphology0.99289422
74MP0009384_cardiac_valve_regurgitation0.98714764
75MP0001915_intracranial_hemorrhage0.98393132
76MP0003453_abnormal_keratinocyte_physiol0.98365900
77MP0001873_stomach_inflammation0.97491448
78MP0000858_altered_metastatic_potential0.96984425
79MP0005666_abnormal_adipose_tissue0.95111408
80MP0009697_abnormal_copulation0.94654303
81MP0000350_abnormal_cell_proliferation0.94305262
82MP0005621_abnormal_cell_physiology0.93831843
83MP0001661_extended_life_span0.93133336
84MP0001348_abnormal_lacrimal_gland0.93058940
85MP0003436_decreased_susceptibility_to0.92089058
86MP0001849_ear_inflammation0.91681033
87MP0003943_abnormal_hepatobiliary_system0.91588607
88MP0000249_abnormal_blood_vessel0.91307719
89MP0000383_abnormal_hair_follicle0.90231375
90MP0002086_abnormal_extraembryonic_tissu0.89872091
91MP0001243_abnormal_dermal_layer0.87345154
92MP0000428_abnormal_craniofacial_morphol0.86605460
93MP0000465_gastrointestinal_hemorrhage0.86043892
94MP0004036_abnormal_muscle_relaxation0.85910378
95MP0005365_abnormal_bile_salt0.85888953
96MP0002080_prenatal_lethality0.84278215
97MP0005379_endocrine/exocrine_gland_phen0.83978204
98MP0005257_abnormal_intraocular_pressure0.83557879
99MP0001545_abnormal_hematopoietic_system0.83303070
100MP0005397_hematopoietic_system_phenotyp0.83303070
101MP0004197_abnormal_fetal_growth/weight/0.82828222
102MP0005409_darkened_coat_color0.82134143
103MP0000609_abnormal_liver_physiology0.81708090
104MP0001697_abnormal_embryo_size0.81664753
105MP0005165_increased_susceptibility_to0.81457717
106MP0002006_tumorigenesis0.80605686
107MP0009333_abnormal_splenocyte_physiolog0.80483728
108MP0002269_muscular_atrophy0.79467253
109MP0000358_abnormal_cell_content/0.79382118
110MP0003984_embryonic_growth_retardation0.79368186
111MP0001216_abnormal_epidermal_layer0.78579469
112MP0004084_abnormal_cardiac_muscle0.78315249
113MP0002088_abnormal_embryonic_growth/wei0.77953571
114MP0000627_abnormal_mammary_gland0.77614713
115MP0002933_joint_inflammation0.77512983
116MP0002078_abnormal_glucose_homeostasis0.76644385
117MP0004484_altered_response_of0.76593668
118MP0009703_decreased_birth_body0.76399937
119MP0000747_muscle_weakness0.75043411
120MP0008260_abnormal_autophagy0.74788989
121MP0005451_abnormal_body_composition0.74265919
122MP0002971_abnormal_brown_adipose0.73946651
123MP0002136_abnormal_kidney_physiology0.73909901
124MP0008961_abnormal_basal_metabolism0.73664189
125MP0005384_cellular_phenotype0.73606114
126MP0003111_abnormal_nucleus_morphology0.73417488
127MP0002405_respiratory_system_inflammati0.72823771
128MP0008004_abnormal_stomach_pH0.71974770
129MP0006138_congestive_heart_failure0.71885067
130MP0003077_abnormal_cell_cycle0.71763440
131MP0003448_altered_tumor_morphology0.71460331
132MP0001672_abnormal_embryogenesis/_devel0.71148458
133MP0005380_embryogenesis_phenotype0.71148458
134MP0001756_abnormal_urination0.71055424
135MP0000371_diluted_coat_color0.70724674
136MP0002419_abnormal_innate_immunity0.70454714
137MP0000749_muscle_degeneration0.68966804
138MP0003795_abnormal_bone_structure0.68313497
139MP0002128_abnormal_blood_circulation0.67826707
140MP0002970_abnormal_white_adipose0.67159948
141MP0001191_abnormal_skin_condition0.66671674
142MP0008007_abnormal_cellular_replicative0.65621362
143MP0009643_abnormal_urine_homeostasis0.65575921
144MP0001879_abnormal_lymphatic_vessel0.65383644
145MP0002928_abnormal_bile_duct0.65370593
146MP0005390_skeleton_phenotype0.64670792
147MP0002295_abnormal_pulmonary_circulatio0.64594564
148MP0004043_abnormal_pH_regulation0.64570671
149MP0002168_other_aberrant_phenotype0.64317086
150MP0001845_abnormal_inflammatory_respons0.63550775
151MP0009115_abnormal_fat_cell0.63427801

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.38954449
2Cervical subluxation (HP:0003308)3.91453950
3Protrusio acetabuli (HP:0003179)3.67912182
4Papilledema (HP:0001085)3.54602156
5Cerebral aneurysm (HP:0004944)3.53146425
6Ankle contracture (HP:0006466)3.34233328
7Osteolytic defects of the phalanges of the hand (HP:0009771)3.33817483
8Osteolytic defects of the hand bones (HP:0009699)3.33817483
9Thoracolumbar scoliosis (HP:0002944)3.24290499
10Dysostosis multiplex (HP:0000943)3.02886912
11Insulin-resistant diabetes mellitus (HP:0000831)2.97810323
12Cardiovascular calcification (HP:0011915)2.97711123
13Abnormality of the common coagulation pathway (HP:0010990)2.96350564
14Asymmetry of the thorax (HP:0001555)2.92322740
15Increased mean platelet volume (HP:0011877)2.85807634
16Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.84374927
17Aortic aneurysm (HP:0004942)2.84297671
18Gingival bleeding (HP:0000225)2.83156361
19Mitral stenosis (HP:0001718)2.82319055
20Dilatation of the ascending aorta (HP:0005111)2.81113438
21Vascular calcification (HP:0004934)2.76796693
22Urinary glycosaminoglycan excretion (HP:0003541)2.76251252
23Mucopolysacchariduria (HP:0008155)2.76251252
24Severe short stature (HP:0003510)2.76078660
25Vertebral compression fractures (HP:0002953)2.72217730
26Short nail (HP:0001799)2.70833046
27Spinal cord lesions (HP:0100561)2.67428267
28Syringomyelia (HP:0003396)2.67428267
29Abnormal platelet volume (HP:0011876)2.66550816
30Hyperglycemia (HP:0003074)2.60733461
31Ankyloglossia (HP:0010296)2.58894846
32Curly hair (HP:0002212)2.57530777
33Broad face (HP:0000283)2.52596293
34Abnormality of the distal phalanges of the toes (HP:0010182)2.50859959
35Menorrhagia (HP:0000132)2.50394252
36Hyperinsulinemic hypoglycemia (HP:0000825)2.50079470
37Shallow orbits (HP:0000586)2.47610510
38Scapular winging (HP:0003691)2.41588994
39Conjugated hyperbilirubinemia (HP:0002908)2.38380044
40Interstitial pulmonary disease (HP:0006530)2.38259028
41Soft skin (HP:0000977)2.37855633
42Wormian bones (HP:0002645)2.37149890
43Spontaneous hematomas (HP:0007420)2.33511344
44Hand muscle atrophy (HP:0009130)2.31026834
45Papillary thyroid carcinoma (HP:0002895)2.30991277
46Thin bony cortex (HP:0002753)2.29848772
47Increased connective tissue (HP:0009025)2.29610631
48Hypoglycemic coma (HP:0001325)2.28851289
49Hypoglycemic seizures (HP:0002173)2.27570637
50Abnormality of polysaccharide metabolism (HP:0011012)2.26934062
51Abnormality of glycosaminoglycan metabolism (HP:0004371)2.26934062
52Abnormality of mucopolysaccharide metabolism (HP:0011020)2.26934062
53Delayed closure of the anterior fontanelle (HP:0001476)2.26081734
54Abnormality of the calcaneus (HP:0008364)2.25176244
55Abnormality of the hip-girdle musculature (HP:0001445)2.23776136
56Abnormality of the musculature of the pelvis (HP:0001469)2.23776136
57Abnormal glucose tolerance (HP:0001952)2.22587888
58Increased density of long bones (HP:0006392)2.22247573
59Myocardial infarction (HP:0001658)2.21685231
60Aortic dissection (HP:0002647)2.21199789
61Subacute progressive viral hepatitis (HP:0006572)2.20490694
62Hypobetalipoproteinemia (HP:0003563)2.17594854
63Exostoses (HP:0100777)2.15959493
64Aneurysm (HP:0002617)2.15838322
65Distal upper limb amyotrophy (HP:0007149)2.14916961
66Upper limb amyotrophy (HP:0009129)2.14916961
67Prolonged bleeding time (HP:0003010)2.14468268
68Epistaxis (HP:0000421)2.13737167
69Abnormality of monocarboxylic acid metabolism (HP:0010996)2.11914503
70Increased cerebral lipofuscin (HP:0011813)2.10076143
71Hematochezia (HP:0002573)2.07633600
72Termporal pattern (HP:0011008)2.05539101
73Insidious onset (HP:0003587)2.05539101
74Abnormal foot bone ossification (HP:0010675)2.03240496
75Eczematoid dermatitis (HP:0000976)2.03018084
76Entropion (HP:0000621)2.00965014
77Periodontitis (HP:0000704)1.99275881
78Hypercortisolism (HP:0001578)1.97894393
79Abnormality of the intrinsic pathway (HP:0010989)1.97877854
80Thickened calvaria (HP:0002684)1.97610692
81Absent frontal sinuses (HP:0002688)1.97159518
82Persistence of primary teeth (HP:0006335)1.96611789
83Multiple enchondromatosis (HP:0005701)1.95847462
84Spinal rigidity (HP:0003306)1.95708479
85Fatigue (HP:0012378)1.95520593
86Macroorchidism (HP:0000053)1.95248046
87Sparse lateral eyebrow (HP:0005338)1.95035780
88Glucose intolerance (HP:0000833)1.94352903
89Cupped ribs (HP:0000887)1.92818463
90Global brain atrophy (HP:0002283)1.92339168
91Abnormality of oral frenula (HP:0000190)1.91411648
92Mildly elevated creatine phosphokinase (HP:0008180)1.89991173
93Mitral valve prolapse (HP:0001634)1.88388690
94Vascular tortuosity (HP:0004948)1.88358255
95Beaking of vertebral bodies (HP:0004568)1.87913864
96Radial bowing (HP:0002986)1.87611906
97Relative macrocephaly (HP:0004482)1.87367746
98Difficulty climbing stairs (HP:0003551)1.87293805
99Abnormality of the acetabulum (HP:0003170)1.85990903
100Dislocated radial head (HP:0003083)1.85771448
101T lymphocytopenia (HP:0005403)1.85613943
102Fair hair (HP:0002286)1.84976273
103Polycythemia (HP:0001901)1.84389993
104Acute myeloid leukemia (HP:0004808)1.84269991
105Deep venous thrombosis (HP:0002625)1.84034741
106Reduced subcutaneous adipose tissue (HP:0003758)1.83548313
107Genu recurvatum (HP:0002816)1.83154020
108Dysmetric saccades (HP:0000641)1.82591793
109Enlarged penis (HP:0000040)1.82274764
110Platyspondyly (HP:0000926)1.81533723
111Orthostatic hypotension (HP:0001278)1.81462765
112Abnormality of T cell number (HP:0011839)1.81161057
113Volvulus (HP:0002580)1.80801734
114Spinal cord compression (HP:0002176)1.80693897
115Joint stiffness (HP:0001387)1.80239572
116Thyroid carcinoma (HP:0002890)1.80121583
117Chronic diarrhea (HP:0002028)1.79290623
118Spinal muscular atrophy (HP:0007269)1.79261406
119Deep philtrum (HP:0002002)1.78522655
120Vertebral hypoplasia (HP:0008417)1.78103811
121Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.78103811
122Peritonitis (HP:0002586)1.77794464
123Buphthalmos (HP:0000557)1.76023455
124Flat acetabular roof (HP:0003180)1.75979183
125Limb-girdle muscle atrophy (HP:0003797)1.75225997
126Coarse hair (HP:0002208)1.73569010
127Bladder diverticulum (HP:0000015)1.73565100
128Ovoid vertebral bodies (HP:0003300)1.72900588
129Overgrowth (HP:0001548)1.72749307
130Insulin resistance (HP:0000855)1.71589400
131Fragile skin (HP:0001030)1.71468798
132Arterial tortuosity (HP:0005116)1.71434775
133Metaphyseal cupping (HP:0003021)1.71250208
134Cutaneous melanoma (HP:0012056)1.69166967
135Abnormality of the odontoid process (HP:0003310)1.68852104
136Hypoplasia of the odontoid process (HP:0003311)1.68825507
137Wrist flexion contracture (HP:0001239)1.68725611
138Testicular neoplasm (HP:0010788)1.68578668
139Symptomatic seizures (HP:0011145)1.68301405
140Missing ribs (HP:0000921)1.67996569
141Long toe (HP:0010511)1.67764975
142Coxa vara (HP:0002812)1.67498853
143Acanthocytosis (HP:0001927)1.67468656
144Gingivitis (HP:0000230)1.67316777
145Autoimmune hemolytic anemia (HP:0001890)1.67265293
146Increased neuronal autofluorescent lipopigment (HP:0002074)1.67236801
147Spondylolisthesis (HP:0003302)1.66916698
148Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.66480463
149Atrophic scars (HP:0001075)1.65792068
150Arterial thrombosis (HP:0004420)1.65670773
151Tetraparesis (HP:0002273)1.65177292
152Resting tremor (HP:0002322)1.64872976
153Focal segmental glomerulosclerosis (HP:0000097)1.64437214
154Striae distensae (HP:0001065)1.64269467
155Generalized hypopigmentation of hair (HP:0011358)1.64196833
156Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.63556927
157Abnormality of skull ossification (HP:0002703)1.62837749
158Submucous cleft hard palate (HP:0000176)1.62737592
159Congenital glaucoma (HP:0001087)1.62416236
160Vertebral arch anomaly (HP:0008438)1.62130083
161Bowel diverticulosis (HP:0005222)1.61761401
162Autoamputation (HP:0001218)1.61385690
163Cranial hyperostosis (HP:0004437)1.61359533
164Fat malabsorption (HP:0002630)1.61151357
165Gastrointestinal infarctions (HP:0005244)1.59278446
166Right ventricular cardiomyopathy (HP:0011663)1.58993939
167Viral hepatitis (HP:0006562)1.58991394

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SCYL23.46452850
2TRIB32.71286518
3FLT32.64668035
4AKT32.43979240
5PDGFRA2.37184613
6FRK2.30908044
7TTN2.29697498
8CDK122.27730207
9TAOK32.23698968
10LATS12.15549121
11PKN22.14669366
12LRRK22.07487271
13STK101.98256174
14PASK1.91454179
15BUB11.89975222
16ACVR1B1.89582109
17RPS6KA41.89396302
18MAP3K21.89182315
19MAP3K141.87084671
20BMPR21.75113549
21EPHA31.73361502
22ERN11.71061246
23PTK61.68021153
24TESK11.67360958
25IRAK11.60748660
26NEK11.59839296
27STK31.53096562
28PTK21.48171471
29YES11.46449801
30MET1.46319701
31CDK61.44778526
32WEE11.37632339
33EPHB11.36421012
34ERBB31.33926904
35MYLK1.33205754
36NLK1.31300931
37NTRK11.29207190
38EEF2K1.27896572
39TRPM71.26920191
40LIMK11.24064775
41MAP3K31.22594497
42IRAK31.21299543
43INSRR1.20912834
44STK391.16966861
45PIM21.16289048
46NEK21.16224560
47MAP3K81.16151214
48ALK1.15674772
49MAP3K61.15453065
50DDR21.14591443
51PDK21.13625878
52EPHA21.11431596
53PAK21.11410211
54BRD41.04909108
55RIPK11.04241193
56WNK11.04079121
57HIPK21.03947900
58CDC71.03239958
59PAK41.00598329
60PRPF4B0.99894636
61TESK20.99663516
62NEK90.98879904
63JAK10.98665555
64MAPK110.97846480
65ERBB40.97486115
66FER0.96080310
67JAK30.93451790
68STK240.92689176
69ICK0.92682564
70IRAK40.92465556
71MAP2K30.89328335
72EIF2AK10.87626809
73MAP3K120.87486326
74RET0.87234619
75FGFR30.85144181
76BTK0.85122790
77MST1R0.84775462
78PAK30.83018510
79PDGFRB0.82964161
80STK380.81650663
81EIF2AK30.81124645
82MTOR0.79959962
83MAP2K10.79502147
84CSK0.78803955
85PTK2B0.77356071
86SIK10.76689204
87NEK60.76599795
88MST40.75564043
89KSR20.73734696
90CAMK1D0.73608337
91IRAK20.73039615
92KDR0.70930776
93MARK30.70885472
94STK38L0.69334842
95CAMK1G0.68934732
96ITK0.68117956
97SGK30.67458482
98RIPK40.67437944
99TGFBR20.65996945
100AURKB0.65740618
101RPS6KB20.65074508
102HCK0.61760111
103BMX0.61735598
104MAPKAPK30.61619799
105FGFR10.61138502
106TGFBR10.60989863
107GRK60.59500585
108NUAK10.59373484
109JAK20.59110067
110DYRK1B0.58955939
111PRKD30.57770504
112MAP3K70.56838083
113MOS0.56228859
114MAP3K130.54738877
115SIK30.54708043
116PBK0.54304846
117PRKCH0.53766705
118* PRKAA20.53314756
119PIK3CA0.52351782
120PDPK10.52238157
121PDK10.50573383
122FGFR40.50530271
123TBK10.49434928
124GSK3A0.49202112
125KSR10.48345454
126PRKD10.48178959
127LMTK20.47240486
128WNK40.46016361
129PIM10.45098712
130CDK40.42161209
131PRKG20.40772508
132TSSK60.38489190
133MAP3K10.38336046
134MAPK150.38032610
135ZAP700.37012987
136PIK3CG0.35874549
137TYK20.35279906
138TEC0.33511550
139PAK10.33252684
140IGF1R0.32960787
141CDC42BPA0.32657489
142MELK0.32590089
143CSNK1A1L0.32353924
144TTK0.30427578
145PLK30.30302965
146EGFR0.30290623

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.19789465
2Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.98529943
3Protein export_Homo sapiens_hsa030601.95713492
4Lysosome_Homo sapiens_hsa041421.89976959
5Complement and coagulation cascades_Homo sapiens_hsa046101.83897995
6Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.79523668
7Antigen processing and presentation_Homo sapiens_hsa046121.76287957
8Chronic myeloid leukemia_Homo sapiens_hsa052201.71306372
9Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.54068729
10Viral carcinogenesis_Homo sapiens_hsa052031.50718835
11p53 signaling pathway_Homo sapiens_hsa041151.45044385
12N-Glycan biosynthesis_Homo sapiens_hsa005101.42391065
13Cell cycle_Homo sapiens_hsa041101.41405600
14Focal adhesion_Homo sapiens_hsa045101.40329988
15Type II diabetes mellitus_Homo sapiens_hsa049301.40082613
16Proteoglycans in cancer_Homo sapiens_hsa052051.37421861
17* mTOR signaling pathway_Homo sapiens_hsa041501.34305813
18Small cell lung cancer_Homo sapiens_hsa052221.33217676
19Pancreatic cancer_Homo sapiens_hsa052121.30849779
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.29893658
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.27795814
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.26844876
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.25368454
24Bladder cancer_Homo sapiens_hsa052191.22863309
25Adherens junction_Homo sapiens_hsa045201.21703535
26Thyroid cancer_Homo sapiens_hsa052161.19682782
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.17203444
28Renin-angiotensin system_Homo sapiens_hsa046141.16910628
29Sulfur metabolism_Homo sapiens_hsa009201.16885388
30RNA transport_Homo sapiens_hsa030131.16735852
31Legionellosis_Homo sapiens_hsa051341.15986597
32Carbohydrate digestion and absorption_Homo sapiens_hsa049731.15726806
33Prostate cancer_Homo sapiens_hsa052151.15543955
34Choline metabolism in cancer_Homo sapiens_hsa052311.14459439
35Type I diabetes mellitus_Homo sapiens_hsa049401.14217269
36Hepatitis C_Homo sapiens_hsa051601.14127001
37Shigellosis_Homo sapiens_hsa051311.14098836
38T cell receptor signaling pathway_Homo sapiens_hsa046601.13699433
39Endocytosis_Homo sapiens_hsa041441.13306610
40Fatty acid biosynthesis_Homo sapiens_hsa000611.11988875
41ABC transporters_Homo sapiens_hsa020101.11669068
42ECM-receptor interaction_Homo sapiens_hsa045121.11583232
43Toxoplasmosis_Homo sapiens_hsa051451.11124391
44MicroRNAs in cancer_Homo sapiens_hsa052061.10311399
45Amoebiasis_Homo sapiens_hsa051461.09840667
46Apoptosis_Homo sapiens_hsa042101.08142694
47Renal cell carcinoma_Homo sapiens_hsa052111.07150858
48Viral myocarditis_Homo sapiens_hsa054161.04181855
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03932192
50Neurotrophin signaling pathway_Homo sapiens_hsa047221.03783139
51* Insulin resistance_Homo sapiens_hsa049311.01251405
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99900004
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99696821
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99577530
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96354748
56Hepatitis B_Homo sapiens_hsa051610.95120412
57Platelet activation_Homo sapiens_hsa046110.95020232
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94059045
59Leishmaniasis_Homo sapiens_hsa051400.93527166
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93360165
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92394761
62Vibrio cholerae infection_Homo sapiens_hsa051100.91961425
63Glioma_Homo sapiens_hsa052140.91849478
64Starch and sucrose metabolism_Homo sapiens_hsa005000.91525315
65Osteoclast differentiation_Homo sapiens_hsa043800.89904679
66Epstein-Barr virus infection_Homo sapiens_hsa051690.89649863
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.89413005
68Histidine metabolism_Homo sapiens_hsa003400.88137487
69Phagosome_Homo sapiens_hsa041450.86312089
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84673841
71Oocyte meiosis_Homo sapiens_hsa041140.84670519
72VEGF signaling pathway_Homo sapiens_hsa043700.84639927
73Influenza A_Homo sapiens_hsa051640.83376947
74Sphingolipid metabolism_Homo sapiens_hsa006000.83171325
75Prolactin signaling pathway_Homo sapiens_hsa049170.83106112
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83000338
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79898764
78Acute myeloid leukemia_Homo sapiens_hsa052210.78844681
79Estrogen signaling pathway_Homo sapiens_hsa049150.78400307
80* Insulin signaling pathway_Homo sapiens_hsa049100.78385631
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76964821
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76687381
83Tuberculosis_Homo sapiens_hsa051520.75991292
84* AMPK signaling pathway_Homo sapiens_hsa041520.75566626
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75298733
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75247928
87* FoxO signaling pathway_Homo sapiens_hsa040680.74808375
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74168397
89Non-small cell lung cancer_Homo sapiens_hsa052230.73621349
90HTLV-I infection_Homo sapiens_hsa051660.73528463
91Hematopoietic cell lineage_Homo sapiens_hsa046400.73386218
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73276049
93Thyroid hormone synthesis_Homo sapiens_hsa049180.72384659
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72201286
95NF-kappa B signaling pathway_Homo sapiens_hsa040640.71756962
96* Adipocytokine signaling pathway_Homo sapiens_hsa049200.71047690
97HIF-1 signaling pathway_Homo sapiens_hsa040660.69597213
98Endometrial cancer_Homo sapiens_hsa052130.69161757
99Measles_Homo sapiens_hsa051620.69002268
100Insulin secretion_Homo sapiens_hsa049110.68890510
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68515760
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68083961
103Protein digestion and absorption_Homo sapiens_hsa049740.68051926
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.67828132
105B cell receptor signaling pathway_Homo sapiens_hsa046620.67519721
106Colorectal cancer_Homo sapiens_hsa052100.65870763
107* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64834559
108ErbB signaling pathway_Homo sapiens_hsa040120.64619897
109Pathways in cancer_Homo sapiens_hsa052000.64386626
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64291450
111Arginine biosynthesis_Homo sapiens_hsa002200.64261678
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63907094
113Chemical carcinogenesis_Homo sapiens_hsa052040.62271225
114Inositol phosphate metabolism_Homo sapiens_hsa005620.61501885
115TNF signaling pathway_Homo sapiens_hsa046680.60973607
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.59975579
117NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59763042
118Pertussis_Homo sapiens_hsa051330.59609861
119Malaria_Homo sapiens_hsa051440.59262943
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58921643
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58271357
122Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57923012
123Other glycan degradation_Homo sapiens_hsa005110.56845348
124* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56503753
125Retinol metabolism_Homo sapiens_hsa008300.56219632
126Chemokine signaling pathway_Homo sapiens_hsa040620.55947053
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55918342
128Dorso-ventral axis formation_Homo sapiens_hsa043200.55481824
129Jak-STAT signaling pathway_Homo sapiens_hsa046300.54951104
130* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54316202
131Mineral absorption_Homo sapiens_hsa049780.53891198
132Pancreatic secretion_Homo sapiens_hsa049720.52695854
133Melanoma_Homo sapiens_hsa052180.52630756
134Selenocompound metabolism_Homo sapiens_hsa004500.51651272

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