PRKAA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of relaxation of muscle (GO:1901077)6.60270255
2response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.49347157
3striated muscle contraction (GO:0006941)5.42693294
4regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.22572990
5lysine catabolic process (GO:0006554)5.21541796
6lysine metabolic process (GO:0006553)5.21541796
7regulation of cell communication by electrical coupling (GO:0010649)5.19662700
8skeletal muscle contraction (GO:0003009)5.05465297
9response to inactivity (GO:0014854)4.93974858
10regulation of actin filament-based movement (GO:1903115)4.92899987
11regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.87044743
12glyoxylate metabolic process (GO:0046487)4.82257472
13actin filament-based movement (GO:0030048)4.82140827
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.79192491
15L-phenylalanine catabolic process (GO:0006559)4.79192491
16cardiac muscle hypertrophy (GO:0003300)4.77926206
17cellular ketone body metabolic process (GO:0046950)4.69188472
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.63225177
19L-phenylalanine metabolic process (GO:0006558)4.63225177
20actomyosin structure organization (GO:0031032)4.58990420
21striated muscle hypertrophy (GO:0014897)4.53695376
22cardiac muscle cell development (GO:0055013)4.44031817
23adult heart development (GO:0007512)4.43469221
24* carnitine shuttle (GO:0006853)4.35825157
25tricarboxylic acid cycle (GO:0006099)4.33135040
262-oxoglutarate metabolic process (GO:0006103)4.32778659
27aromatic amino acid family catabolic process (GO:0009074)4.26877184
28* fatty acid transmembrane transport (GO:1902001)4.25901550
29aspartate family amino acid catabolic process (GO:0009068)4.23726875
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.23593705
31kynurenine metabolic process (GO:0070189)4.20838085
32cardiac cell development (GO:0055006)4.12238318
33ketone body metabolic process (GO:1902224)4.04910636
34alpha-linolenic acid metabolic process (GO:0036109)4.00388477
35acetyl-CoA metabolic process (GO:0006084)3.98348848
36cardiac muscle tissue morphogenesis (GO:0055008)3.94771358
37regulation of sarcomere organization (GO:0060297)3.93399735
38regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.93359904
39negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.89510785
40muscle contraction (GO:0006936)3.89472779
41muscle hypertrophy (GO:0014896)3.88668963
42regulation of striated muscle contraction (GO:0006942)3.86053029
43sarcomere organization (GO:0045214)3.85549680
44tryptophan catabolic process (GO:0006569)3.85422752
45indole-containing compound catabolic process (GO:0042436)3.85422752
46indolalkylamine catabolic process (GO:0046218)3.85422752
47fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.85060530
48sulfur amino acid catabolic process (GO:0000098)3.85001293
49positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.82762857
50response to muscle activity (GO:0014850)3.82660595
51cysteine metabolic process (GO:0006534)3.82027259
52muscle tissue morphogenesis (GO:0060415)3.80784196
53fatty acid beta-oxidation (GO:0006635)3.75977772
54relaxation of cardiac muscle (GO:0055119)3.74012291
55bile acid biosynthetic process (GO:0006699)3.72726866
56short-chain fatty acid metabolic process (GO:0046459)3.71446682
57actin-myosin filament sliding (GO:0033275)3.70057165
58muscle filament sliding (GO:0030049)3.70057165
59amino-acid betaine metabolic process (GO:0006577)3.69281571
60muscle fiber development (GO:0048747)3.68869290
61dicarboxylic acid biosynthetic process (GO:0043650)3.65029675
62positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.64992387
63succinate metabolic process (GO:0006105)3.59690127
64tryptophan metabolic process (GO:0006568)3.58427890
65response to caffeine (GO:0031000)3.56745003
66regulation of membrane repolarization (GO:0060306)3.56715728
67fatty acid oxidation (GO:0019395)3.55015619
68triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.54721592
69muscle system process (GO:0003012)3.52208032
70regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.50656507
71regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.50570832
72regulation of the force of heart contraction (GO:0002026)3.50012969
73homocysteine metabolic process (GO:0050667)3.49974912
74lipid oxidation (GO:0034440)3.47871812
75serine family amino acid catabolic process (GO:0009071)3.47155978
76creatine metabolic process (GO:0006600)3.46833512
77cardiac myofibril assembly (GO:0055003)3.46512376
78fatty acid catabolic process (GO:0009062)3.43996448
79myotube cell development (GO:0014904)3.42079372
80alpha-amino acid catabolic process (GO:1901606)3.41998693
81* amino-acid betaine transport (GO:0015838)3.39215078
82* carnitine transport (GO:0015879)3.39215078
83glutamate metabolic process (GO:0006536)3.38668903
84striated muscle cell development (GO:0055002)3.37274813
85cellular glucuronidation (GO:0052695)3.36333294
86urea cycle (GO:0000050)3.34871438
87urea metabolic process (GO:0019627)3.34871438
88cardiac muscle cell action potential (GO:0086001)3.34443160
89negative regulation of potassium ion transmembrane transport (GO:1901380)3.32199039
90monocarboxylic acid catabolic process (GO:0072329)3.31740448
91* carnitine transmembrane transport (GO:1902603)3.31506354
92regulation of cardiac muscle cell contraction (GO:0086004)3.31180437
93cellular amino acid catabolic process (GO:0009063)3.30396328
94regulation of skeletal muscle contraction (GO:0014819)3.30235059
95positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.29955349
96regulation of acyl-CoA biosynthetic process (GO:0050812)3.29473761
97myofibril assembly (GO:0030239)3.29101436
98cell communication by electrical coupling (GO:0010644)3.28924122
99regulation of calcium ion transmembrane transport (GO:1903169)3.26610863
100regulation of calcium ion transmembrane transporter activity (GO:1901019)3.26610863
101cardiac muscle adaptation (GO:0014887)3.26045658
102cardiac muscle hypertrophy in response to stress (GO:0014898)3.26045658
103muscle hypertrophy in response to stress (GO:0003299)3.26045658
104regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.24866544
105branched-chain amino acid catabolic process (GO:0009083)3.24199253
106drug transmembrane transport (GO:0006855)3.23139206
107drug catabolic process (GO:0042737)3.22766931
108coenzyme catabolic process (GO:0009109)3.22007040
109negative regulation of sterol transport (GO:0032372)3.21980118
110negative regulation of cholesterol transport (GO:0032375)3.21980118
111flavonoid metabolic process (GO:0009812)3.20216666
112skeletal muscle fiber development (GO:0048741)3.19823321
113negative regulation of cytosolic calcium ion concentration (GO:0051481)3.19801973
114glycogen catabolic process (GO:0005980)3.18319246
115carnitine metabolic process (GO:0009437)3.17418991
116ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.17346087
117NADH metabolic process (GO:0006734)3.17060649
118relaxation of muscle (GO:0090075)3.16853582
119bile acid metabolic process (GO:0008206)3.16813681
120sarcoplasmic reticulum calcium ion transport (GO:0070296)3.16300276
121muscle cell cellular homeostasis (GO:0046716)3.15309733
122tricarboxylic acid metabolic process (GO:0072350)3.13058513
123regulation of triglyceride catabolic process (GO:0010896)3.12968737
124ethanol oxidation (GO:0006069)3.12774963
125striated muscle adaptation (GO:0014888)3.12428604
126otic vesicle formation (GO:0030916)3.11321414
127actin-mediated cell contraction (GO:0070252)3.10943142
128response to mercury ion (GO:0046689)3.09975158
129oxaloacetate metabolic process (GO:0006107)3.09895200
130organic acid catabolic process (GO:0016054)3.09490572
131carboxylic acid catabolic process (GO:0046395)3.09490572
132cellular modified amino acid catabolic process (GO:0042219)3.08692322
133cardiac muscle contraction (GO:0060048)3.08644028
134ventricular cardiac muscle cell action potential (GO:0086005)3.08400624
135valine metabolic process (GO:0006573)3.07939037
136glucan catabolic process (GO:0009251)3.07838602
137branched-chain amino acid metabolic process (GO:0009081)3.07672364
138complement activation, alternative pathway (GO:0006957)3.06719695
139regulation of heart rate (GO:0002027)3.06666896
140aromatic amino acid family metabolic process (GO:0009072)3.05707415
141nitrogen cycle metabolic process (GO:0071941)3.05698545
142plasma membrane repair (GO:0001778)3.05421312
143regulation of protein activation cascade (GO:2000257)3.05392879
144regulation of fatty acid oxidation (GO:0046320)3.02879394
145regulation of cardiac muscle contraction (GO:0055117)3.02359053
146regulation of cofactor metabolic process (GO:0051193)3.01436258
147regulation of coenzyme metabolic process (GO:0051196)3.01436258
148phospholipid homeostasis (GO:0055091)3.01162070
149bundle of His cell to Purkinje myocyte communication (GO:0086069)3.01129902
150* quaternary ammonium group transport (GO:0015697)2.98842326
151positive regulation of cation channel activity (GO:2001259)2.98495748
152cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.97940315
153cell communication involved in cardiac conduction (GO:0086065)2.97639780
154uronic acid metabolic process (GO:0006063)2.97271975
155glucuronate metabolic process (GO:0019585)2.97271975
156cardiac muscle cell action potential involved in contraction (GO:0086002)2.97009225
157skeletal muscle adaptation (GO:0043501)2.93554846
158regulation of potassium ion transmembrane transporter activity (GO:1901016)2.87759235
159muscle cell development (GO:0055001)2.87112499
160positive regulation of sodium ion transport (GO:0010765)2.85652060
161regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.84250227
162positive regulation of sodium ion transmembrane transport (GO:1902307)2.84024221
163cardiac chamber formation (GO:0003207)2.78353564
164detection of calcium ion (GO:0005513)2.78143696
165positive regulation of ion transmembrane transporter activity (GO:0032414)2.73164238
166skeletal muscle tissue development (GO:0007519)2.72616526
167cardiac ventricle formation (GO:0003211)2.71064123
168negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.69911390
169negative regulation of calcium ion transmembrane transport (GO:1903170)2.69911390
170regulation of ATP catabolic process (GO:1903289)2.66231062
171regulation of ATPase activity (GO:0043462)2.66231062
172heart contraction (GO:0060047)2.65620969
173heart process (GO:0003015)2.65620969
174regulation of sodium ion transmembrane transport (GO:1902305)2.63338195
175regulation of cation channel activity (GO:2001257)2.62808599
176regulation of muscle system process (GO:0090257)2.60201506
177positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.59760250
178myotube differentiation (GO:0014902)2.56864751
179negative regulation of protein localization to cell surface (GO:2000009)2.55344469

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.00396735
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.04479906
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.94265586
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.34970985
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.12762060
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.40896715
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.14066349
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.01912613
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.85234433
10* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.68737389
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.55457828
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.52153547
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.42074036
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37684639
15IGF1R_20145208_ChIP-Seq_DFB_Human2.25636356
16* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.22893125
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13069886
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.09684530
19* FUS_26573619_Chip-Seq_HEK293_Human2.05826991
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01421075
21* EP300_21415370_ChIP-Seq_HL-1_Mouse1.94361787
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.93639843
23ESR1_20079471_ChIP-ChIP_T-47D_Human1.91819670
24ZNF263_19887448_ChIP-Seq_K562_Human1.90471659
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.85228072
26CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.81162203
27* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75330556
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.69301277
29P300_19829295_ChIP-Seq_ESCs_Human1.65025210
30MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.63234597
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62141350
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59310371
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.56985338
34FOXA2_19822575_ChIP-Seq_HepG2_Human1.47017464
35* STAT3_23295773_ChIP-Seq_U87_Human1.45692233
36* SMAD3_21741376_ChIP-Seq_EPCs_Human1.45247380
37TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.43068972
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.42284259
39TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40906153
40* TBX20_22328084_ChIP-Seq_HEART_Mouse1.40706352
41* TBX20_22080862_ChIP-Seq_HEART_Mouse1.40706352
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40338621
43EZH2_22144423_ChIP-Seq_EOC_Human1.40253955
44* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.39669646
45TCF4_23295773_ChIP-Seq_U87_Human1.38904446
46EWS_26573619_Chip-Seq_HEK293_Human1.37951866
47NR3C1_21868756_ChIP-Seq_MCF10A_Human1.36699075
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.35633504
49GBX2_23144817_ChIP-Seq_PC3_Human1.35055069
50RNF2_27304074_Chip-Seq_NSC_Mouse1.34848352
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34845376
52CLOCK_20551151_ChIP-Seq_293T_Human1.33136595
53BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.32090141
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31915693
55SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.31050407
56RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26252628
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24167402
58TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23874977
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.23604766
60FOXM1_26456572_ChIP-Seq_MCF-7_Human1.23222798
61KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22159705
62ER_23166858_ChIP-Seq_MCF-7_Human1.21915062
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21494952
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21493004
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21493004
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21355544
67SOX9_26525672_Chip-Seq_HEART_Mouse1.17228072
68ESR1_21235772_ChIP-Seq_MCF-7_Human1.17139009
69RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16487478
70E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15528997
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13407154
72SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.12036412
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12032379
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11204399
75MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10321316
76TP53_16413492_ChIP-PET_HCT116_Human1.09872051
77HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09655367
78HTT_18923047_ChIP-ChIP_STHdh_Human1.09495652
79CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08678040
80SOX2_19829295_ChIP-Seq_ESCs_Human1.07511273
81NANOG_19829295_ChIP-Seq_ESCs_Human1.07511273
82BCAT_22108803_ChIP-Seq_LS180_Human1.07269201
83* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07188335
84* TBL1_22424771_ChIP-Seq_293T_Human1.05785625
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05624934
86* HNF4A_19822575_ChIP-Seq_HepG2_Human1.05141192
87BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04586724
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04259441
89NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04259441
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03877198
91TAF15_26573619_Chip-Seq_HEK293_Human1.03615729
92LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03489217
93ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01710292
94TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01523532
95TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01085202
96RNF2_27304074_Chip-Seq_ESCs_Mouse1.00495660
97NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00389885
98P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99666656
99PIAS1_25552417_ChIP-Seq_VCAP_Human0.99415658
100* NANOG_18555785_Chip-Seq_ESCs_Mouse0.99207751
101SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99092363
102NFE2_27457419_Chip-Seq_LIVER_Mouse0.99023038
103FLI1_21867929_ChIP-Seq_TH2_Mouse0.98999348
104SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.98920313
105AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.98845479
106DROSHA_22980978_ChIP-Seq_HELA_Human0.98565220
107RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98157859
108EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98157859
109ERG_21242973_ChIP-ChIP_JURKAT_Human0.98155176
110SOX2_21211035_ChIP-Seq_LN229_Gbm0.97705833
111NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96694234
112PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93164194
113TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93086916
114ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92095012
115AR_21572438_ChIP-Seq_LNCaP_Human0.89779388
116GATA1_22025678_ChIP-Seq_K562_Human0.89505122
117SMAD4_21741376_ChIP-Seq_HESCs_Human0.87984506
118AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87915474
119SOX2_27498859_Chip-Seq_STOMACH_Mouse0.87904099
120AHR_22903824_ChIP-Seq_MCF-7_Human0.87758830
121* SMAD4_21799915_ChIP-Seq_A2780_Human0.87401946
122ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87319179
123PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86838160
124EZH2_27294783_Chip-Seq_ESCs_Mouse0.85902828
125GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.84863891
126ZNF274_21170338_ChIP-Seq_K562_Hela0.84835448
127* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.84047700
128SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.82641293
129* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81478906
130JARID2_20075857_ChIP-Seq_MESCs_Mouse0.80734940
131ARNT_22903824_ChIP-Seq_MCF-7_Human0.78809449
132CTCF_27219007_Chip-Seq_Bcells_Human0.78537558
133SMAD3_21741376_ChIP-Seq_HESCs_Human0.77787410
134RARB_27405468_Chip-Seq_BRAIN_Mouse0.77268850
135PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76718266
136MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.76314265
137SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.75288354
138JARID2_20064375_ChIP-Seq_MESCs_Mouse0.74586288
139VDR_22108803_ChIP-Seq_LS180_Human0.73745847
140AR_25329375_ChIP-Seq_VCAP_Human0.73116422
141TRIM28_21343339_ChIP-Seq_HEK293_Human0.72596875
142MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.72502857
143GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.71712422
144AR_19668381_ChIP-Seq_PC3_Human0.71682658
145CDX2_20551321_ChIP-Seq_CACO-2_Human0.70760137
146IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.70069853
147CBP_20019798_ChIP-Seq_JUKART_Human0.70069853
148EZH2_27304074_Chip-Seq_ESCs_Mouse0.70003678
149NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.69650046
150WT1_25993318_ChIP-Seq_PODOCYTE_Human0.69552898
151CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.68771890
152ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.68373722
153RXR_22108803_ChIP-Seq_LS180_Human0.68171533
154CTBP1_25329375_ChIP-Seq_LNCAP_Human0.68165218
155REST_18959480_ChIP-ChIP_MESCs_Mouse0.67999867
156ISL1_27105846_Chip-Seq_CPCs_Mouse0.66572956
157* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.66366664
158SUZ12_27294783_Chip-Seq_ESCs_Mouse0.66207704
159DNAJC2_21179169_ChIP-ChIP_NT2_Human0.65827752

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.31734909
2MP0005360_urolithiasis5.14128893
3MP0005085_abnormal_gallbladder_physiolo4.38792582
4MP0002837_dystrophic_cardiac_calcinosis4.03144723
5MP0005365_abnormal_bile_salt3.90476173
6MP0003646_muscle_fatigue3.68340160
7MP0008875_abnormal_xenobiotic_pharmacok3.15465658
8MP0000751_myopathy3.09215348
9MP0004084_abnormal_cardiac_muscle2.92718648
10MP0003806_abnormal_nucleotide_metabolis2.79747937
11MP0004036_abnormal_muscle_relaxation2.78135200
12MP0000749_muscle_degeneration2.65363085
13MP0003252_abnormal_bile_duct2.64092315
14MP0004215_abnormal_myocardial_fiber2.59131546
15* MP0004130_abnormal_muscle_cell2.36520979
16MP0004145_abnormal_muscle_electrophysio2.29377999
17MP0005332_abnormal_amino_acid2.26709355
18MP0005330_cardiomyopathy2.23589044
19MP0010329_abnormal_lipoprotein_level2.14781651
20MP0003195_calcinosis2.13441999
21MP0005083_abnormal_biliary_tract2.00091661
22MP0005620_abnormal_muscle_contractility1.96581938
23MP0004087_abnormal_muscle_fiber1.96363820
24MP0002269_muscular_atrophy1.93772984
25MP0002972_abnormal_cardiac_muscle1.86639272
26MP0000747_muscle_weakness1.80528785
27MP0006036_abnormal_mitochondrial_physio1.73906617
28MP0001666_abnormal_nutrient_absorption1.71852383
29MP0003950_abnormal_plasma_membrane1.70451385
30MP0004484_altered_response_of1.65965919
31MP0004043_abnormal_pH_regulation1.65193643
32MP0002106_abnormal_muscle_physiology1.65009751
33* MP0002118_abnormal_lipid_homeostasis1.55304686
34MP0003137_abnormal_impulse_conducting1.51878780
35MP0008775_abnormal_heart_ventricle1.51853913
36MP0004019_abnormal_vitamin_homeostasis1.48309684
37MP0001661_extended_life_span1.43226585
38MP0009840_abnormal_foam_cell1.42187913
39MP0001544_abnormal_cardiovascular_syste1.39393451
40MP0005385_cardiovascular_system_phenoty1.39393451
41MP0005319_abnormal_enzyme/_coenzyme1.39338867
42MP0005451_abnormal_body_composition1.37402167
43MP0005369_muscle_phenotype1.31306174
44MP0002138_abnormal_hepatobiliary_system1.31223496
45MP0005584_abnormal_enzyme/coenzyme_acti1.30868483
46MP0006138_congestive_heart_failure1.30080770
47MP0010630_abnormal_cardiac_muscle1.29566488
48MP0004233_abnormal_muscle_weight1.29521676
49MP0000759_abnormal_skeletal_muscle1.29061725
50MP0002638_abnormal_pupillary_reflex1.23704707
51MP0000750_abnormal_muscle_regeneration1.22906781
52MP0004085_abnormal_heartbeat1.22903765
53MP0005423_abnormal_somatic_nervous1.22824003
54MP0003221_abnormal_cardiomyocyte_apopto1.22014726
55MP0000013_abnormal_adipose_tissue1.20862802
56MP0006035_abnormal_mitochondrial_morpho1.20684641
57MP0000733_abnormal_muscle_development1.18927014
58MP0000609_abnormal_liver_physiology1.17510277
59MP0009780_abnormal_chondrocyte_physiolo1.16798752
60MP0003880_abnormal_central_pattern1.13396356
61MP0005666_abnormal_adipose_tissue1.12330971
62MP0001299_abnormal_eye_distance/1.10247832
63MP0001984_abnormal_olfaction1.09596085
64MP0003868_abnormal_feces_composition1.08797271
65MP0002909_abnormal_adrenal_gland1.08623035
66* MP0009643_abnormal_urine_homeostasis1.07341918
67MP0002332_abnormal_exercise_endurance1.05126237
68MP0003136_yellow_coat_color1.04363348
69MP0003705_abnormal_hypodermis_morpholog1.03397343
70MP0010030_abnormal_orbit_morphology1.02261983
71MP0004270_analgesia0.98805469
72MP0002822_catalepsy0.97322154
73MP0002234_abnormal_pharynx_morphology0.96897273
74MP0005535_abnormal_body_temperature0.93772391
75MP0000230_abnormal_systemic_arterial0.90655842
76* MP0002078_abnormal_glucose_homeostasis0.89987887
77MP0005636_abnormal_mineral_homeostasis0.88868948
78MP0002971_abnormal_brown_adipose0.88626926
79MP0005670_abnormal_white_adipose0.88308297
80* MP0005266_abnormal_metabolism0.85952430
81MP0003191_abnormal_cellular_cholesterol0.85756362
82MP0002734_abnormal_mechanical_nocicepti0.85622724
83MP0003329_amyloid_beta_deposits0.84472167
84MP0005187_abnormal_penis_morphology0.81927604
85MP0002127_abnormal_cardiovascular_syste0.80745853
86MP0001529_abnormal_vocalization0.79977820
87MP0001765_abnormal_ion_homeostasis0.78656264
88MP0001764_abnormal_homeostasis0.77968201
89MP0001756_abnormal_urination0.75759492
90MP0000579_abnormal_nail_morphology0.75747055
91MP0000266_abnormal_heart_morphology0.74071508
92MP0004142_abnormal_muscle_tone0.73506509
93MP0010234_abnormal_vibrissa_follicle0.72639794
94MP0005248_abnormal_Harderian_gland0.72630037
95MP0008961_abnormal_basal_metabolism0.72448374
96MP0001486_abnormal_startle_reflex0.72215081
97MP0003937_abnormal_limbs/digits/tail_de0.71514479
98MP0001346_abnormal_lacrimal_gland0.69791512
99MP0004859_abnormal_synaptic_plasticity0.68543295
100MP0005334_abnormal_fat_pad0.68470615
101MP0002876_abnormal_thyroid_physiology0.68203121
102MP0005551_abnormal_eye_electrophysiolog0.67322740
103MP0002938_white_spotting0.67012893
104MP0003890_abnormal_embryonic-extraembry0.66715299
105MP0000372_irregular_coat_pigmentation0.65108778
106MP0005253_abnormal_eye_physiology0.63170987
107MP0002272_abnormal_nervous_system0.62606357
108MP0004185_abnormal_adipocyte_glucose0.60813730
109MP0006072_abnormal_retinal_apoptosis0.60395298
110MP0009384_cardiac_valve_regurgitation0.60213236
111MP0004510_myositis0.59844281
112MP0009046_muscle_twitch0.59425385
113MP0003122_maternal_imprinting0.58922689
114MP0003045_fibrosis0.58479077
115MP0003755_abnormal_palate_morphology0.58402005
116MP0003567_abnormal_fetal_cardiomyocyte0.58341875
117MP0003656_abnormal_erythrocyte_physiolo0.57812784
118* MP0009745_abnormal_behavioral_response0.57595923
119MP0006292_abnormal_olfactory_placode0.57363678
120MP0010368_abnormal_lymphatic_system0.57330282
121MP0000631_abnormal_neuroendocrine_gland0.57281292
122MP0005375_adipose_tissue_phenotype0.57038420
123MP0002233_abnormal_nose_morphology0.55790847
124MP0000003_abnormal_adipose_tissue0.55588342
125MP0009250_abnormal_appendicular_skeleto0.54681153
126MP0002108_abnormal_muscle_morphology0.54662272
127* MP0009642_abnormal_blood_homeostasis0.53641841
128MP0000778_abnormal_nervous_system0.53233694
129MP0000604_amyloidosis0.53011518
130MP0005084_abnormal_gallbladder_morpholo0.52759915
131* MP0005376_homeostasis/metabolism_phenot0.52479127
132MP0000566_synostosis0.52049795
133MP0005165_increased_susceptibility_to0.51357748
134MP0004147_increased_porphyrin_level0.50562338
135MP0004924_abnormal_behavior0.50243525
136MP0005386_behavior/neurological_phenoty0.50243525
137MP0000534_abnormal_ureter_morphology0.50016359
138MP0002064_seizures0.49439793
139MP0005646_abnormal_pituitary_gland0.48754993
140MP0000598_abnormal_liver_morphology0.48437608
141MP0004133_heterotaxia0.48342982
142MP0001485_abnormal_pinna_reflex0.48137556
143MP0002067_abnormal_sensory_capabilities0.48030073
144MP0003828_pulmonary_edema0.46842719
145MP0001293_anophthalmia0.46615895
146MP0003942_abnormal_urinary_system0.46507931
147MP0002128_abnormal_blood_circulation0.46439603
148* MP0003953_abnormal_hormone_level0.46319520
149* MP0005448_abnormal_energy_balance0.45901877
150MP0003635_abnormal_synaptic_transmissio0.45896172
151MP0002735_abnormal_chemical_nociception0.45852308
152MP0009672_abnormal_birth_weight0.45493971

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)5.00947929
2Exercise-induced muscle cramps (HP:0003710)4.78489668
3Sudden death (HP:0001699)4.57687269
4Rimmed vacuoles (HP:0003805)4.33185737
5Myoglobinuria (HP:0002913)4.23905544
6Calf muscle hypertrophy (HP:0008981)4.03483120
7Muscle hypertrophy of the lower extremities (HP:0008968)4.00085372
8Intrahepatic cholestasis (HP:0001406)3.94957306
9Ketosis (HP:0001946)3.87980519
10Ketoacidosis (HP:0001993)3.81107445
11Deep venous thrombosis (HP:0002625)3.76084259
12Abnormality of aromatic amino acid family metabolism (HP:0004338)3.65819058
13Myopathic facies (HP:0002058)3.65698070
14Hyperammonemia (HP:0001987)3.60836847
15Hypoglycemic coma (HP:0001325)3.59833134
16Neck muscle weakness (HP:0000467)3.53441120
17Gout (HP:0001997)3.50087438
18Muscle fiber splitting (HP:0003555)3.47827682
19Hyperglycinuria (HP:0003108)3.44768087
20Xanthomatosis (HP:0000991)3.42242476
21Hyporeflexia of lower limbs (HP:0002600)3.35943429
22Abnormality of fatty-acid metabolism (HP:0004359)3.25578965
23Ventricular tachycardia (HP:0004756)3.23891420
24Right ventricular cardiomyopathy (HP:0011663)3.23491890
25Abnormality of serine family amino acid metabolism (HP:0010894)3.17282580
26Abnormality of glycine metabolism (HP:0010895)3.17282580
27Abnormality of monocarboxylic acid metabolism (HP:0010996)3.17193796
28Rhabdomyolysis (HP:0003201)3.15781516
29Hypobetalipoproteinemia (HP:0003563)3.15610852
30Abnormality of the calf musculature (HP:0001430)3.13453542
31Hyperglycinemia (HP:0002154)3.12928464
32Muscle fiber inclusion bodies (HP:0100299)3.03076835
33Distal lower limb muscle weakness (HP:0009053)3.02666718
34Hypoalphalipoproteinemia (HP:0003233)3.01403430
35Abnormality of dicarboxylic acid metabolism (HP:0010995)2.94153606
36Dicarboxylic aciduria (HP:0003215)2.94153606
37Syncope (HP:0001279)2.93722704
38Frequent falls (HP:0002359)2.92987516
39Hypolipoproteinemia (HP:0010981)2.92690069
40Calcaneovalgus deformity (HP:0001848)2.92480790
41Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.91631723
42Centrally nucleated skeletal muscle fibers (HP:0003687)2.90535492
43Absent phalangeal crease (HP:0006109)2.89535868
44Ulnar deviation of the wrist (HP:0003049)2.89485137
45Round ear (HP:0100830)2.88500522
46Fetal akinesia sequence (HP:0001989)2.87454621
47EMG: myopathic abnormalities (HP:0003458)2.81678746
48Hyperlipoproteinemia (HP:0010980)2.81573084
49Cerebral edema (HP:0002181)2.78278597
50Areflexia of lower limbs (HP:0002522)2.78027135
51Palpitations (HP:0001962)2.77651656
52Abnormality of glutamine family amino acid metabolism (HP:0010902)2.76812813
53EMG: neuropathic changes (HP:0003445)2.67083625
54Hyperuricemia (HP:0002149)2.66857655
55Increased purine levels (HP:0004368)2.66857655
56Generalized muscle weakness (HP:0003324)2.66317089
57Epidermoid cyst (HP:0200040)2.65944276
58Atrial fibrillation (HP:0005110)2.65634261
59Prolonged partial thromboplastin time (HP:0003645)2.63879374
60Abnormality of purine metabolism (HP:0004352)2.63699802
61Subaortic stenosis (HP:0001682)2.60484841
62Abnormality of the left ventricular outflow tract (HP:0011103)2.60484841
63Asymmetric septal hypertrophy (HP:0001670)2.60134618
64Metabolic acidosis (HP:0001942)2.59264657
65Muscle stiffness (HP:0003552)2.58666184
66Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.58485829
67Complement deficiency (HP:0004431)2.58232230
68Hip contracture (HP:0003273)2.57685750
69Deformed tarsal bones (HP:0008119)2.56861026
70Abnormality of aspartate family amino acid metabolism (HP:0010899)2.53541005
71Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.53105266
72Difficulty running (HP:0009046)2.51631297
73Nemaline bodies (HP:0003798)2.49620898
74Type 1 muscle fiber predominance (HP:0003803)2.49498276
75Ventricular arrhythmia (HP:0004308)2.48814678
76Lipoatrophy (HP:0100578)2.48153924
77Primary atrial arrhythmia (HP:0001692)2.47343874
78Myotonia (HP:0002486)2.46556334
79Abnormal finger flexion creases (HP:0006143)2.44051769
80Abnormality of skeletal muscle fiber size (HP:0012084)2.40170131
81Lethargy (HP:0001254)2.39029735
82Cholelithiasis (HP:0001081)2.34082239
83Abnormal atrioventricular conduction (HP:0005150)2.33254145
84Proximal tubulopathy (HP:0000114)2.33208397
85Bundle branch block (HP:0011710)2.33052049
86Supraventricular tachycardia (HP:0004755)2.32692936
87Hyperventilation (HP:0002883)2.32402107
88Gowers sign (HP:0003391)2.32111207
89Limb-girdle muscle atrophy (HP:0003797)2.28111556
90Supraventricular arrhythmia (HP:0005115)2.27637648
91Scapular winging (HP:0003691)2.27551855
92Dilated cardiomyopathy (HP:0001644)2.26390557
93Muscular dystrophy (HP:0003560)2.26097093
94Proximal amyotrophy (HP:0007126)2.25796050
95Hyperkalemia (HP:0002153)2.24529114
96Abnormality of sulfur amino acid metabolism (HP:0004339)2.24524648
97Acute encephalopathy (HP:0006846)2.24182960
98Prolonged QT interval (HP:0001657)2.22914634
99Abnormal gallbladder morphology (HP:0012437)2.22575820
100Abnormality of serum amino acid levels (HP:0003112)2.22540147
101Left ventricular hypertrophy (HP:0001712)2.22085625
102Generalized aminoaciduria (HP:0002909)2.19025985
103Increased variability in muscle fiber diameter (HP:0003557)2.17980295
104Increased connective tissue (HP:0009025)2.17505531
105Limited hip movement (HP:0008800)2.15506139
106Skin nodule (HP:0200036)2.15165959
107Fat malabsorption (HP:0002630)2.14881139
108Heart block (HP:0012722)2.11937300
109Abnormality of nucleobase metabolism (HP:0010932)2.11836294
110Atrioventricular block (HP:0001678)2.11653854
111Delayed CNS myelination (HP:0002188)2.11294465
112Hyperinsulinemic hypoglycemia (HP:0000825)2.10691449
113Hyperglycemia (HP:0003074)2.09767927
114Mildly elevated creatine phosphokinase (HP:0008180)2.08915924
115Ventricular fibrillation (HP:0001663)2.07101734
116Ragged-red muscle fibers (HP:0003200)2.04448909
117Malignant hyperthermia (HP:0002047)2.03869862
118Vomiting (HP:0002013)2.02216330
119Pheochromocytoma (HP:0002666)2.00766041
120Abnormality of methionine metabolism (HP:0010901)2.00741845
121Late onset (HP:0003584)2.00095384
122Abnormal gallbladder physiology (HP:0012438)1.99614852
123Cholecystitis (HP:0001082)1.99614852
124Abnormality of the shoulder girdle musculature (HP:0001435)1.96927409
125Hepatic necrosis (HP:0002605)1.95079979
126Distal arthrogryposis (HP:0005684)1.94980892
127Conjunctival hamartoma (HP:0100780)1.94778648
128Abnormal mitochondria in muscle tissue (HP:0008316)1.94555867
129Neonatal onset (HP:0003623)1.93560447
130Abnormality of urine glucose concentration (HP:0011016)1.92473949
131Glycosuria (HP:0003076)1.92473949
132Abnormality of the foot musculature (HP:0001436)1.92373907
133Waddling gait (HP:0002515)1.84950476
134Long clavicles (HP:0000890)1.74857902
135Aplasia of the musculature (HP:0100854)1.69327339
136Diaphragmatic weakness (HP:0009113)1.68076100
137Steppage gait (HP:0003376)1.67704721
138Foot dorsiflexor weakness (HP:0009027)1.65907512
139Broad-based gait (HP:0002136)1.63289670
140Weak cry (HP:0001612)1.63010623
141Fatigable weakness (HP:0003473)1.59524453
142Abnormality of the neuromuscular junction (HP:0003398)1.59524453
143Abnormality of the calcaneus (HP:0008364)1.58794712
144Nonprogressive disorder (HP:0003680)1.55988869
145Progressive muscle weakness (HP:0003323)1.54733010
146Bulbar palsy (HP:0001283)1.51107934
147Exercise intolerance (HP:0003546)1.49501905
148Increased serum pyruvate (HP:0003542)1.47664569
149Respiratory insufficiency due to muscle weakness (HP:0002747)1.46991593
150Abnormality of the ischium (HP:0003174)1.46398702
151Abnormality of potassium homeostasis (HP:0011042)1.42825125
152Abnormal EKG (HP:0003115)1.40125840
153Abnormality of glycolysis (HP:0004366)1.36121325
154Difficulty climbing stairs (HP:0003551)1.35689013
155Metatarsus adductus (HP:0001840)1.34266944
156Distal lower limb amyotrophy (HP:0008944)1.33761240
157Toxemia of pregnancy (HP:0100603)1.33392671
158Abnormality of the musculature of the pelvis (HP:0001469)1.33238801

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.52516677
2PHKG13.67264309
3PHKG23.67264309
4BCKDK3.44766001
5PDK33.02486147
6PDK43.02486147
7TTN2.98881182
8PKN22.45829356
9NEK12.43210646
10MAP2K42.11353460
11LMTK22.03652720
12WNK41.96560939
13MYLK1.92686534
14TRIB31.90625621
15PINK11.87164359
16PDK21.70739114
17PIK3CA1.67882491
18INSRR1.63777521
19SIK11.62650006
20TNIK1.61363388
21STK241.59538421
22DMPK1.48340008
23MAP3K41.46096677
24MARK11.45189270
25MST1R1.37784812
26FRK1.33528755
27MAPK121.26784394
28NME11.23494942
29DAPK21.22044447
30PIK3CG1.19267520
31MAP3K91.16474426
32STK38L1.16212061
33WNK31.16207243
34ERBB31.11510017
35PNCK1.08796257
36CAMK1D1.08248262
37PAK31.03443042
38OXSR11.03318302
39LATS21.03233958
40LATS11.03056482
41STK391.00340688
42* PRKAA10.99422552
43BMPR1B0.99211524
44TIE10.98390263
45RIPK10.98323866
46EPHA40.97369282
47CAMK1G0.96922887
48TRPM70.94147068
49FGFR40.92500072
50ERBB40.92376356
51STK380.89375377
52KSR20.88725865
53* MAP3K70.85886855
54MAP4K20.84537710
55PTK60.81211105
56LIMK10.79258061
57* PRKAA20.77491855
58MAPK130.75809196
59MAPK110.74668192
60MUSK0.74630497
61STK30.73463340
62CAMK2D0.73368227
63CAMKK10.72682318
64CAMK2G0.72314464
65SGK30.71949705
66PAK60.71607017
67SGK2230.71176317
68SGK4940.71176317
69EPHA30.69152181
70CAMKK20.67841127
71CAMK40.66729101
72MAP2K70.65972269
73CAMK2A0.65563977
74SGK20.64715855
75MINK10.64451385
76MAP2K60.62729995
77RET0.62227451
78CCNB10.62218607
79NTRK30.61126002
80PRKG10.59892495
81PDPK10.57255194
82EEF2K0.56865445
83MAP3K50.56291773
84MAPKAPK30.55981639
85FLT30.55366437
86ROCK10.55328733
87CAMK2B0.54742483
88MAP2K30.54718837
89PRKCE0.54342416
90PRKD10.53900137
91NLK0.53748484
92GRK70.53645953
93AKT20.53342809
94DAPK30.52266258
95* PRKACG0.50863327
96PDK10.50582941
97CAMK10.50443496
98BRSK20.50387111
99PKN10.50203665
100MAP2K10.46726230
101MET0.46347340
102ILK0.44890496
103ZAK0.44725004
104KSR10.44191974
105PLK20.44012143
106PRKCZ0.43906417
107ERN10.43295996
108FGFR10.42504530
109PRKACA0.42124181
110PRKACB0.41722503
111SGK10.41603043
112WNK10.41534078
113NTRK10.41511226
114CDC42BPA0.41476834
115EPHB20.40242259
116NEK90.39489074
117MAP3K20.39438693
118FGFR20.39084327
119RPS6KA30.38315586
120JAK20.37605266
121ACVR1B0.36832382
122CSNK1G10.36022861
123FER0.36003047
124CASK0.35503044
125WEE10.35415723
126ARAF0.34879621
127MKNK20.33112634
128BCR0.31981005
129PRKDC0.31550572
130CSNK1E0.30171128
131STK40.28935448
132TLK10.28357905
133AKT30.27933423
134ADRBK20.27500755
135RPS6KB10.26172404
136NTRK20.25927975
137MAPK100.25723123
138PRKCG0.24333822
139NUAK10.23407548

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.54588114
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.08405551
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.93185607
4Propanoate metabolism_Homo sapiens_hsa006402.88205666
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.87155056
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.84755414
7Fatty acid degradation_Homo sapiens_hsa000712.80931290
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.70094418
9Nitrogen metabolism_Homo sapiens_hsa009102.62630121
10Butanoate metabolism_Homo sapiens_hsa006502.54380616
11Arginine biosynthesis_Homo sapiens_hsa002202.49314009
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.45316700
13Tryptophan metabolism_Homo sapiens_hsa003802.22358951
14Fatty acid metabolism_Homo sapiens_hsa012122.20614116
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.12059104
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.10055870
17Pyruvate metabolism_Homo sapiens_hsa006201.98738022
18Carbon metabolism_Homo sapiens_hsa012001.91327401
19* Circadian rhythm_Homo sapiens_hsa047101.88743631
20Peroxisome_Homo sapiens_hsa041461.72690550
21PPAR signaling pathway_Homo sapiens_hsa033201.69927824
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.69089847
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.67926769
24Starch and sucrose metabolism_Homo sapiens_hsa005001.61032382
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.57085046
26Sulfur metabolism_Homo sapiens_hsa009201.52362805
27beta-Alanine metabolism_Homo sapiens_hsa004101.49581144
28Cardiac muscle contraction_Homo sapiens_hsa042601.49298578
29Bile secretion_Homo sapiens_hsa049761.47967513
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.38757630
31Complement and coagulation cascades_Homo sapiens_hsa046101.34938656
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.29992028
33Biosynthesis of amino acids_Homo sapiens_hsa012301.29828505
34Phenylalanine metabolism_Homo sapiens_hsa003601.27750435
35Fatty acid elongation_Homo sapiens_hsa000621.24989026
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.17009294
37Caffeine metabolism_Homo sapiens_hsa002321.11538172
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.07730038
39Chemical carcinogenesis_Homo sapiens_hsa052041.07607783
40Tight junction_Homo sapiens_hsa045301.05218248
41Fat digestion and absorption_Homo sapiens_hsa049751.05138596
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.04109564
43Circadian entrainment_Homo sapiens_hsa047131.03709000
44Histidine metabolism_Homo sapiens_hsa003401.03399980
45Dilated cardiomyopathy_Homo sapiens_hsa054141.00493437
46Oxidative phosphorylation_Homo sapiens_hsa001901.00147691
47Parkinsons disease_Homo sapiens_hsa050120.97248872
48Tyrosine metabolism_Homo sapiens_hsa003500.97012933
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95084699
50* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.94057602
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92247707
52Retinol metabolism_Homo sapiens_hsa008300.91560271
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.89249728
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.89059006
55Arginine and proline metabolism_Homo sapiens_hsa003300.88049756
56Fatty acid biosynthesis_Homo sapiens_hsa000610.88031108
57Nicotine addiction_Homo sapiens_hsa050330.86894310
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.86398672
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.83912918
60Hedgehog signaling pathway_Homo sapiens_hsa043400.79683482
61Basal cell carcinoma_Homo sapiens_hsa052170.79523750
62Olfactory transduction_Homo sapiens_hsa047400.78415607
63Phototransduction_Homo sapiens_hsa047440.76802465
64ABC transporters_Homo sapiens_hsa020100.76691709
65Alzheimers disease_Homo sapiens_hsa050100.76430578
66Lysine degradation_Homo sapiens_hsa003100.76189938
67Selenocompound metabolism_Homo sapiens_hsa004500.75660317
68* Glucagon signaling pathway_Homo sapiens_hsa049220.74656135
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73754067
70Salivary secretion_Homo sapiens_hsa049700.73041807
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70569640
72Hippo signaling pathway_Homo sapiens_hsa043900.70231733
73* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69640939
74Glycerolipid metabolism_Homo sapiens_hsa005610.68235976
75Taste transduction_Homo sapiens_hsa047420.66216805
76cAMP signaling pathway_Homo sapiens_hsa040240.63280700
77Fructose and mannose metabolism_Homo sapiens_hsa000510.62162512
78* Insulin resistance_Homo sapiens_hsa049310.61938547
79Glutamatergic synapse_Homo sapiens_hsa047240.61503611
80Galactose metabolism_Homo sapiens_hsa000520.59988947
81Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59202666
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57541157
83Amphetamine addiction_Homo sapiens_hsa050310.57294717
84Morphine addiction_Homo sapiens_hsa050320.56396941
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.56349915
86Dopaminergic synapse_Homo sapiens_hsa047280.55418964
87Adherens junction_Homo sapiens_hsa045200.54700841
88Vitamin digestion and absorption_Homo sapiens_hsa049770.49159286
89RNA degradation_Homo sapiens_hsa030180.49050616
90Purine metabolism_Homo sapiens_hsa002300.48732558
91* Insulin signaling pathway_Homo sapiens_hsa049100.48547813
92* Adipocytokine signaling pathway_Homo sapiens_hsa049200.48354446
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48234494
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46503385
95* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45325807
96Pancreatic secretion_Homo sapiens_hsa049720.43988804
97Ovarian steroidogenesis_Homo sapiens_hsa049130.42364901
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41970939
99Melanogenesis_Homo sapiens_hsa049160.41734582
100Metabolic pathways_Homo sapiens_hsa011000.41730106
101Wnt signaling pathway_Homo sapiens_hsa043100.41129645
102Pentose phosphate pathway_Homo sapiens_hsa000300.40469014
103* AMPK signaling pathway_Homo sapiens_hsa041520.40299926
104Huntingtons disease_Homo sapiens_hsa050160.40285454
105Staphylococcus aureus infection_Homo sapiens_hsa051500.39980778
106Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39873593
107TGF-beta signaling pathway_Homo sapiens_hsa043500.39012462
108Thyroid hormone synthesis_Homo sapiens_hsa049180.38605648
109Cholinergic synapse_Homo sapiens_hsa047250.38135762
110Oocyte meiosis_Homo sapiens_hsa041140.37200674
111Maturity onset diabetes of the young_Homo sapiens_hsa049500.36855547
112Long-term depression_Homo sapiens_hsa047300.36806852
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34338335
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33104385
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32340375
116Insulin secretion_Homo sapiens_hsa049110.29847657
117Folate biosynthesis_Homo sapiens_hsa007900.29614337
118Glutathione metabolism_Homo sapiens_hsa004800.29515450
119Gastric acid secretion_Homo sapiens_hsa049710.28443479
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.27524995
121Calcium signaling pathway_Homo sapiens_hsa040200.27311596
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27168605
123Sulfur relay system_Homo sapiens_hsa041220.24817762
124Steroid biosynthesis_Homo sapiens_hsa001000.24648150
125Type II diabetes mellitus_Homo sapiens_hsa049300.23913531
126* Oxytocin signaling pathway_Homo sapiens_hsa049210.21038940
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.19926746
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.19403279
129GABAergic synapse_Homo sapiens_hsa047270.19136462
130Renin secretion_Homo sapiens_hsa049240.18858331
131Vitamin B6 metabolism_Homo sapiens_hsa007500.18772180
132Aldosterone synthesis and secretion_Homo sapiens_hsa049250.18754637
133Linoleic acid metabolism_Homo sapiens_hsa005910.18294783
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.18015258

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