PRKAB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)7.28137266
2muscle filament sliding (GO:0030049)7.28137266
3sarcoplasmic reticulum calcium ion transport (GO:0070296)7.07601614
4regulation of skeletal muscle contraction (GO:0014819)7.07266722
5positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.48074391
6actin-mediated cell contraction (GO:0070252)6.04505624
7skeletal muscle contraction (GO:0003009)5.83576034
8regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.60802498
9regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.58550403
10plasma membrane repair (GO:0001778)5.54454911
11skeletal muscle adaptation (GO:0043501)5.24563066
12sarcomere organization (GO:0045214)5.18016465
13regulation of cell communication by electrical coupling (GO:0010649)5.13515856
14very-low-density lipoprotein particle assembly (GO:0034379)4.83974347
15negative regulation of fibrinolysis (GO:0051918)4.81027301
16striated muscle contraction (GO:0006941)4.75517733
17plasma lipoprotein particle assembly (GO:0034377)4.74899526
18myofibril assembly (GO:0030239)4.68839912
19actin filament-based movement (GO:0030048)4.61801460
20protein-lipid complex assembly (GO:0065005)4.57245788
21neuronal action potential propagation (GO:0019227)4.50037670
22regulation of fibrinolysis (GO:0051917)4.42459659
23skeletal muscle fiber development (GO:0048741)4.29232637
24negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.25570248
25response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.21718841
26regulation of cholesterol esterification (GO:0010872)4.07904532
27regulation of protein activation cascade (GO:2000257)4.05625365
28regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.05428729
29cardiac muscle contraction (GO:0060048)4.03026222
30peptidyl-glutamic acid carboxylation (GO:0017187)4.00469745
31protein carboxylation (GO:0018214)4.00469745
32regulation of calcium ion transmembrane transport (GO:1903169)3.94619654
33regulation of calcium ion transmembrane transporter activity (GO:1901019)3.94619654
34high-density lipoprotein particle remodeling (GO:0034375)3.92726547
35regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.87719332
36glycogen catabolic process (GO:0005980)3.86949817
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.86631228
38regulation of complement activation (GO:0030449)3.86331391
39muscle contraction (GO:0006936)3.83474349
40cardiac myofibril assembly (GO:0055003)3.83445245
41regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.83223703
42myotube cell development (GO:0014904)3.82706864
43regulation of relaxation of muscle (GO:1901077)3.81858773
44negative regulation of potassium ion transmembrane transport (GO:1901380)3.79505676
45triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.77144406
46positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.75389068
47actomyosin structure organization (GO:0031032)3.72492073
48response to inactivity (GO:0014854)3.71178563
49protein-lipid complex remodeling (GO:0034368)3.70015436
50macromolecular complex remodeling (GO:0034367)3.70015436
51plasma lipoprotein particle remodeling (GO:0034369)3.70015436
52phospholipid efflux (GO:0033700)3.67069078
53cholesterol efflux (GO:0033344)3.66397465
54reverse cholesterol transport (GO:0043691)3.57813607
55blood coagulation, intrinsic pathway (GO:0007597)3.57274396
56glucan catabolic process (GO:0009251)3.56693685
57regulation of membrane repolarization (GO:0060306)3.54473885
58cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.50674264
59membrane depolarization during action potential (GO:0086010)3.50330499
60muscle fiber development (GO:0048747)3.48454560
61muscle system process (GO:0003012)3.45995082
62regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.44897614
63neuromuscular synaptic transmission (GO:0007274)3.43671201
64regulation of acyl-CoA biosynthetic process (GO:0050812)3.42326092
65negative regulation of cholesterol transport (GO:0032375)3.41828452
66negative regulation of sterol transport (GO:0032372)3.41828452
67muscle cell cellular homeostasis (GO:0046716)3.39698354
68striated muscle adaptation (GO:0014888)3.38219058
69striated muscle atrophy (GO:0014891)3.36630262
70regulation of actin filament-based movement (GO:1903115)3.36365950
71plasma lipoprotein particle organization (GO:0071827)3.32971620
72protein-lipid complex subunit organization (GO:0071825)3.31943999
73low-density lipoprotein particle remodeling (GO:0034374)3.28640828
74cellular polysaccharide catabolic process (GO:0044247)3.28330649
75regulation of striated muscle contraction (GO:0006942)3.26678137
76negative regulation of lipase activity (GO:0060192)3.19801606
77creatine metabolic process (GO:0006600)3.19265520
78synaptic vesicle maturation (GO:0016188)3.18741862
79regulation of bile acid biosynthetic process (GO:0070857)3.18316509
80embryonic retina morphogenesis in camera-type eye (GO:0060059)3.18094813
81NADH metabolic process (GO:0006734)3.17016069
82complement activation, alternative pathway (GO:0006957)3.17009191
83regulation of cofactor metabolic process (GO:0051193)3.15991926
84regulation of coenzyme metabolic process (GO:0051196)3.15991926
85negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.15668905
86regulation of cation channel activity (GO:2001257)3.15200544
87positive regulation of cation channel activity (GO:2001259)3.13557237
88cell communication by electrical coupling (GO:0010644)3.12835191
89polysaccharide catabolic process (GO:0000272)3.10263876
90regulation of short-term neuronal synaptic plasticity (GO:0048172)3.09401890
91positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.08946520
92fructose metabolic process (GO:0006000)3.04633351
93intestinal cholesterol absorption (GO:0030299)3.01777028
94glutamate metabolic process (GO:0006536)2.98982639
95erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.97874514
96L-phenylalanine catabolic process (GO:0006559)2.97874514
97cell communication involved in cardiac conduction (GO:0086065)2.97638168
98regulation of plasminogen activation (GO:0010755)2.96746388
99regulation of synapse structural plasticity (GO:0051823)2.96506266
100regulation of skeletal muscle cell differentiation (GO:2001014)2.95665910
101neuromuscular junction development (GO:0007528)2.95106326
102muscle atrophy (GO:0014889)2.94463816
103positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.93875835
104locomotory exploration behavior (GO:0035641)2.93128492
105response to muscle activity (GO:0014850)2.92561251
106skeletal muscle tissue regeneration (GO:0043403)2.91562099
107detection of calcium ion (GO:0005513)2.91062457
108epoxygenase P450 pathway (GO:0019373)2.90534285
109regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.90533946
110regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.87048864
111negative regulation of calcium ion transmembrane transport (GO:1903170)2.86015159
112negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.86015159
113vocalization behavior (GO:0071625)2.85848236
114pyrimidine ribonucleoside catabolic process (GO:0046133)2.85798343
115glyoxylate metabolic process (GO:0046487)2.85758359
116ethanol oxidation (GO:0006069)2.85169476
117regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.83463888
1182-oxoglutarate metabolic process (GO:0006103)2.83414505
119plasma lipoprotein particle clearance (GO:0034381)2.82334192
120phospholipid homeostasis (GO:0055091)2.81292631
121erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.80565737
122L-phenylalanine metabolic process (GO:0006558)2.80565737
123synaptic vesicle exocytosis (GO:0016079)2.80051056
124cardiac muscle cell development (GO:0055013)2.79502479
125striated muscle hypertrophy (GO:0014897)2.78767356
126regulation of cholesterol homeostasis (GO:2000188)2.77807530
127acylglycerol homeostasis (GO:0055090)2.75947319
128triglyceride homeostasis (GO:0070328)2.75947319
129striated muscle cell development (GO:0055002)2.75249838
130glycogen biosynthetic process (GO:0005978)2.74501764
131glucan biosynthetic process (GO:0009250)2.74501764
132synaptic vesicle docking involved in exocytosis (GO:0016081)2.73785895
133fibrinolysis (GO:0042730)2.73768126
134cardiac muscle hypertrophy (GO:0003300)2.72892121
135dicarboxylic acid biosynthetic process (GO:0043650)2.72071906
136regulation of synaptic vesicle exocytosis (GO:2000300)2.72047061
137regulation of apoptotic cell clearance (GO:2000425)2.71184004
138positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.69544788
139negative regulation of muscle hypertrophy (GO:0014741)2.69401225
140regulation of potassium ion transmembrane transporter activity (GO:1901016)2.69378972
141myotube differentiation (GO:0014902)2.66598621
142muscle adaptation (GO:0043500)2.66015602
143activation of protein kinase A activity (GO:0034199)2.65972970
144cardiac muscle cell action potential (GO:0086001)2.65372035
145positive regulation of myoblast differentiation (GO:0045663)2.64973543
146potassium ion import (GO:0010107)2.64744674
147tricarboxylic acid cycle (GO:0006099)2.62986710
148glutamate secretion (GO:0014047)2.62857040
149ventricular cardiac muscle cell action potential (GO:0086005)2.62764759
150positive regulation of potassium ion transmembrane transport (GO:1901381)2.62142169
151regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.62029093
152response to mercury ion (GO:0046689)2.60516006
153negative regulation of fatty acid biosynthetic process (GO:0045717)2.60394232
154negative regulation of protein activation cascade (GO:2000258)2.58652198
155COPII vesicle coating (GO:0048208)2.57651062
156paraxial mesoderm development (GO:0048339)2.57500748
157negative regulation of protein localization to cell surface (GO:2000009)2.57007799
158exogenous drug catabolic process (GO:0042738)2.54868590
159gluconeogenesis (GO:0006094)2.54817272
160intestinal absorption (GO:0050892)2.53383674
161cellular glucuronidation (GO:0052695)2.53354731
162fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.52282933
163negative regulation of hemostasis (GO:1900047)2.50660586
164negative regulation of blood coagulation (GO:0030195)2.50660586
1654-hydroxyproline metabolic process (GO:0019471)2.49150161

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.87249801
2EZH2_22144423_ChIP-Seq_EOC_Human4.75683540
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.38115774
4GBX2_23144817_ChIP-Seq_PC3_Human2.50224083
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.48413533
6LXR_22158963_ChIP-Seq_LIVER_Mouse2.47261054
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.47234122
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.44393613
9WT1_19549856_ChIP-ChIP_CCG9911_Human2.41843876
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.38237489
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.32717388
12CLOCK_20551151_ChIP-Seq_293T_Human2.31737299
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.28865083
14FOXA2_19822575_ChIP-Seq_HepG2_Human2.27745698
15DROSHA_22980978_ChIP-Seq_HELA_Human2.23397352
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.22728026
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.22728026
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.20234640
19AR_21572438_ChIP-Seq_LNCaP_Human2.18437960
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.18160466
21CDX2_19796622_ChIP-Seq_MESCs_Mouse2.17166762
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.16772296
23MTF2_20144788_ChIP-Seq_MESCs_Mouse2.13313261
24RARB_27405468_Chip-Seq_BRAIN_Mouse2.06806978
25EZH2_27304074_Chip-Seq_ESCs_Mouse2.06061217
26JARID2_20075857_ChIP-Seq_MESCs_Mouse2.03284936
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.02899320
28EP300_21415370_ChIP-Seq_HL-1_Mouse2.02224498
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.99608734
30SALL4_18804426_ChIP-ChIP_XEN_Mouse1.99438064
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.97239440
32PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.95408581
33PPARA_22158963_ChIP-Seq_LIVER_Mouse1.95123795
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.92316198
35ZNF274_21170338_ChIP-Seq_K562_Hela1.87550503
36* ESR1_20079471_ChIP-ChIP_T-47D_Human1.82223156
37ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.81555467
38* TCF4_18268006_ChIP-ChIP_LS174T_Human1.79659761
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.73113895
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.72972128
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72733881
42SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.72386508
43NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.67782154
44REST_21632747_ChIP-Seq_MESCs_Mouse1.63621933
45* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.61891028
46TRIM28_21343339_ChIP-Seq_HEK293_Human1.61543899
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60947487
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.55332989
49* HNF4A_19822575_ChIP-Seq_HepG2_Human1.53690946
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.52007996
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.51576634
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.49401571
53HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.47423949
54* SMAD4_21799915_ChIP-Seq_A2780_Human1.46037229
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.45727357
56* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42878521
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42851847
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.41313348
59TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.39894414
60REST_18959480_ChIP-ChIP_MESCs_Mouse1.39848398
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.39335998
62CTNNB1_20460455_ChIP-Seq_HCT116_Human1.38548100
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35863224
64HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.35420428
65AR_21909140_ChIP-Seq_LNCAP_Human1.33370944
66WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32654041
67IGF1R_20145208_ChIP-Seq_DFB_Human1.31934431
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27430035
69TBX20_22328084_ChIP-Seq_HEART_Mouse1.25854661
70TBX20_22080862_ChIP-Seq_HEART_Mouse1.25854661
71EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25181864
72* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24930955
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24278318
74ZNF263_19887448_ChIP-Seq_K562_Human1.23830851
75ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23161249
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22066422
77NFIB_24661679_ChIP-Seq_LUNG_Mouse1.21538721
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21000025
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20859298
80* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20384662
81ISL1_27105846_Chip-Seq_CPCs_Mouse1.20085981
82AR_19668381_ChIP-Seq_PC3_Human1.19638169
83AR_25329375_ChIP-Seq_VCAP_Human1.18973415
84SMAD_19615063_ChIP-ChIP_OVARY_Human1.18634950
85WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18335509
86FLI1_27457419_Chip-Seq_LIVER_Mouse1.17863353
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16841381
88PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.16370539
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16210592
90NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.15881169
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15169934
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.14201273
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13449094
94FUS_26573619_Chip-Seq_HEK293_Human1.12886253
95* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10578039
96EZH2_27294783_Chip-Seq_NPCs_Mouse1.10346309
97PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09524756
98MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.07952433
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07296834
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.05631005
101STAT3_23295773_ChIP-Seq_U87_Human1.05592499
102* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05355167
103HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04971332
104* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04535152
105AHR_22903824_ChIP-Seq_MCF-7_Human1.04521847
106SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04518739
107* CTCF_27219007_Chip-Seq_Bcells_Human1.04503685
108P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04400220
109ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04357601
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04092654
111RING1B_27294783_Chip-Seq_ESCs_Mouse1.04066068
112SMAD3_21741376_ChIP-Seq_EPCs_Human1.03934203
113TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03791686
114SMAD3_21741376_ChIP-Seq_HESCs_Human1.03635886
115* BCAT_22108803_ChIP-Seq_LS180_Human1.03529295
116TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03131156
117TP53_18474530_ChIP-ChIP_U2OS_Human1.02737442
118KDM2B_26808549_Chip-Seq_K562_Human1.02648625
119TP53_16413492_ChIP-PET_HCT116_Human1.02149728
120GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02129150
121DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01859151
122CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01826103
123EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01779424
124SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.01723564
125FOXO3_23340844_ChIP-Seq_DLD1_Human1.01395092
126CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01134105
127SMAD4_21741376_ChIP-Seq_HESCs_Human0.99274372
128YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98945227
129CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.98914720
130POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98864136
131PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98644642
132CBP_20019798_ChIP-Seq_JUKART_Human0.98399706
133IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98399706
134ESR2_21235772_ChIP-Seq_MCF-7_Human0.98309201
135TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98227249
136RXR_22108803_ChIP-Seq_LS180_Human0.98099058
137OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98069008
138CBX2_27304074_Chip-Seq_ESCs_Mouse0.97687360
139TAF15_26573619_Chip-Seq_HEK293_Human0.97622702
140NANOG_21062744_ChIP-ChIP_HESCs_Human0.97084734
141GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.97057215
142TCF4_23295773_ChIP-Seq_U87_Human0.96547006
143P300_19829295_ChIP-Seq_ESCs_Human0.96436886
144ERG_21242973_ChIP-ChIP_JURKAT_Human0.95542850
145PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94505685
146EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94290560
147TP53_20018659_ChIP-ChIP_R1E_Mouse0.93876937
148POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93662797
149ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92318782
150STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91812141
151TCF3_18692474_ChIP-Seq_MESCs_Mouse0.91483544
152NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91259364
153NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91259364
154FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91083887
155STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91053811
156MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90668969
157TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88790334
158NFE2_27457419_Chip-Seq_LIVER_Mouse0.88706343
159* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.88585688
160FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.88343992
161SMAD3_21741376_ChIP-Seq_ESCs_Human0.88138428
162ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88035203
163NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87003566
164E2F1_18555785_Chip-Seq_ESCs_Mouse0.86909672
165TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86887068

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio6.12287609
2MP0000751_myopathy4.94351677
3MP0000749_muscle_degeneration4.78270351
4MP0003646_muscle_fatigue4.63307074
5MP0002837_dystrophic_cardiac_calcinosis3.75258260
6MP0004036_abnormal_muscle_relaxation3.51895141
7MP0000747_muscle_weakness3.22871003
8MP0002139_abnormal_hepatobiliary_system3.19982502
9MP0002106_abnormal_muscle_physiology3.15468658
10MP0004859_abnormal_synaptic_plasticity3.07137023
11MP0004270_analgesia2.82436597
12MP0004087_abnormal_muscle_fiber2.80302148
13MP0000759_abnormal_skeletal_muscle2.78917282
14MP0005620_abnormal_muscle_contractility2.75030199
15MP0002269_muscular_atrophy2.75009439
16MP0004130_abnormal_muscle_cell2.69276670
17MP0005369_muscle_phenotype2.68350263
18MP0003941_abnormal_skin_development2.60689659
19MP0004233_abnormal_muscle_weight2.48701752
20MP0004084_abnormal_cardiac_muscle2.44352105
21MP0000750_abnormal_muscle_regeneration2.43521496
22MP0005085_abnormal_gallbladder_physiolo2.36950940
23MP0005360_urolithiasis2.36414451
24MP0004215_abnormal_myocardial_fiber2.28140513
25MP0005365_abnormal_bile_salt2.25962934
26MP0004272_abnormal_basement_membrane2.19380615
27MP0003122_maternal_imprinting2.18383819
28MP0005451_abnormal_body_composition2.08654907
29MP0005330_cardiomyopathy2.05944757
30MP0010329_abnormal_lipoprotein_level2.02647053
31MP0003195_calcinosis1.98506062
32MP0001666_abnormal_nutrient_absorption1.89383944
33MP0003635_abnormal_synaptic_transmissio1.85297416
34MP0003890_abnormal_embryonic-extraembry1.79952675
35MP0002972_abnormal_cardiac_muscle1.74776492
36MP0004484_altered_response_of1.73230472
37MP0002108_abnormal_muscle_morphology1.71203075
38MP0003880_abnormal_central_pattern1.65336549
39MP0009697_abnormal_copulation1.56119345
40MP0003137_abnormal_impulse_conducting1.53574414
41MP0002332_abnormal_exercise_endurance1.50359689
42MP0002734_abnormal_mechanical_nocicepti1.47947231
43MP0009046_muscle_twitch1.43184305
44MP0003868_abnormal_feces_composition1.42403244
45MP0002063_abnormal_learning/memory/cond1.39242040
46MP0000013_abnormal_adipose_tissue1.38683434
47MP0009745_abnormal_behavioral_response1.37445805
48MP0001661_extended_life_span1.36287316
49MP0009780_abnormal_chondrocyte_physiolo1.34786302
50MP0000733_abnormal_muscle_development1.33676868
51MP0009840_abnormal_foam_cell1.27978958
52MP0010630_abnormal_cardiac_muscle1.27451399
53MP0001968_abnormal_touch/_nociception1.26398390
54MP0004085_abnormal_heartbeat1.23885999
55MP0005409_darkened_coat_color1.23804297
56MP0010368_abnormal_lymphatic_system1.22697592
57MP0002064_seizures1.21657320
58MP0001915_intracranial_hemorrhage1.21207227
59MP0004858_abnormal_nervous_system1.16587297
60MP0009672_abnormal_birth_weight1.15899360
61MP0008569_lethality_at_weaning1.15808153
62MP0005385_cardiovascular_system_phenoty1.14641557
63MP0001544_abnormal_cardiovascular_syste1.14641557
64MP0002909_abnormal_adrenal_gland1.14638740
65MP0002735_abnormal_chemical_nociception1.14494757
66MP0008775_abnormal_heart_ventricle1.13842492
67MP0001440_abnormal_grooming_behavior1.13829532
68MP0004510_myositis1.12891691
69MP0003385_abnormal_body_wall1.10488178
70MP0003123_paternal_imprinting1.09469575
71MP0008438_abnormal_cutaneous_collagen1.07835020
72MP0003252_abnormal_bile_duct1.07727579
73MP0002272_abnormal_nervous_system1.07370630
74MP0006036_abnormal_mitochondrial_physio1.06405860
75MP0002067_abnormal_sensory_capabilities1.05480108
76MP0003566_abnormal_cell_adhesion1.04508610
77MP0005332_abnormal_amino_acid1.02280201
78MP0001299_abnormal_eye_distance/1.01560980
79MP0004185_abnormal_adipocyte_glucose1.01136189
80MP0002572_abnormal_emotion/affect_behav1.00581010
81MP0003567_abnormal_fetal_cardiomyocyte0.99481416
82MP0002184_abnormal_innervation0.99225241
83MP0003221_abnormal_cardiomyocyte_apopto0.97635604
84MP0001486_abnormal_startle_reflex0.97139367
85MP0008961_abnormal_basal_metabolism0.95933529
86MP0005423_abnormal_somatic_nervous0.92679817
87MP0002697_abnormal_eye_size0.92182076
88MP0002127_abnormal_cardiovascular_syste0.90655319
89MP0002234_abnormal_pharynx_morphology0.90435812
90MP0009384_cardiac_valve_regurgitation0.90224968
91MP0002089_abnormal_postnatal_growth/wei0.90048401
92MP0002822_catalepsy0.89535133
93MP0002736_abnormal_nociception_after0.89226945
94MP0003705_abnormal_hypodermis_morpholog0.88638160
95MP0002733_abnormal_thermal_nociception0.85649630
96MP0006035_abnormal_mitochondrial_morpho0.85348722
97MP0001501_abnormal_sleep_pattern0.85203184
98MP0006138_congestive_heart_failure0.85024957
99MP0003329_amyloid_beta_deposits0.84011065
100MP0005623_abnormal_meninges_morphology0.83965780
101MP0000566_synostosis0.82847895
102MP0000955_abnormal_spinal_cord0.82361072
103MP0004924_abnormal_behavior0.81556241
104MP0005386_behavior/neurological_phenoty0.81556241
105MP0005666_abnormal_adipose_tissue0.81498615
106MP0002233_abnormal_nose_morphology0.80261344
107MP0004811_abnormal_neuron_physiology0.79426458
108MP0000762_abnormal_tongue_morphology0.79124803
109MP0002066_abnormal_motor_capabilities/c0.77423391
110MP0000534_abnormal_ureter_morphology0.76934370
111MP0001970_abnormal_pain_threshold0.76641852
112MP0005375_adipose_tissue_phenotype0.76411542
113MP0010030_abnormal_orbit_morphology0.73837139
114MP0009703_decreased_birth_body0.73426578
115MP0003937_abnormal_limbs/digits/tail_de0.73038366
116MP0003950_abnormal_plasma_membrane0.72446578
117MP0005670_abnormal_white_adipose0.72032123
118MP0006276_abnormal_autonomic_nervous0.71796266
119MP0004142_abnormal_muscle_tone0.71386310
120MP0004043_abnormal_pH_regulation0.71166887
121MP0003045_fibrosis0.71012339
122MP0002128_abnormal_blood_circulation0.70472054
123MP0002118_abnormal_lipid_homeostasis0.69586424
124MP0008875_abnormal_xenobiotic_pharmacok0.69053581
125MP0001730_embryonic_growth_arrest0.68957780
126MP0004197_abnormal_fetal_growth/weight/0.68773176
127MP0003984_embryonic_growth_retardation0.68723658
128MP0000003_abnormal_adipose_tissue0.68035947
129MP0003119_abnormal_digestive_system0.67549159
130MP0002971_abnormal_brown_adipose0.67498609
131MP0002084_abnormal_developmental_patter0.66668970
132MP0002088_abnormal_embryonic_growth/wei0.65920844
133MP0002882_abnormal_neuron_morphology0.65526372
134MP0001529_abnormal_vocalization0.64780273
135MP0000778_abnormal_nervous_system0.64010926
136MP0003942_abnormal_urinary_system0.63726751
137MP0003121_genomic_imprinting0.62891291
138MP0003935_abnormal_craniofacial_develop0.62738052
139MP0000462_abnormal_digestive_system0.61141477
140MP0000428_abnormal_craniofacial_morphol0.60363257
141MP0005380_embryogenesis_phenotype0.60050083
142MP0001672_abnormal_embryogenesis/_devel0.60050083
143MP0000266_abnormal_heart_morphology0.59174981
144MP0003879_abnormal_hair_cell0.57678439
145MP0002557_abnormal_social/conspecific_i0.56932326
146MP0005187_abnormal_penis_morphology0.52855191
147MP0003828_pulmonary_edema0.52759715
148MP0005275_abnormal_skin_tensile0.51928510
149MP0003283_abnormal_digestive_organ0.51561149
150MP0003633_abnormal_nervous_system0.51278401
151MP0009250_abnormal_appendicular_skeleto0.50713073
152MP0004134_abnormal_chest_morphology0.49136257
153MP0005503_abnormal_tendon_morphology0.48829962
154MP0005535_abnormal_body_temperature0.48571075
155MP0000230_abnormal_systemic_arterial0.47429256
156MP0001943_abnormal_respiration0.46529909

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)7.76810727
2Muscle fiber inclusion bodies (HP:0100299)7.17143030
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.98629477
4Exercise-induced muscle cramps (HP:0003710)6.93215015
5Muscle hypertrophy of the lower extremities (HP:0008968)6.56438774
6Nemaline bodies (HP:0003798)6.32524501
7Calf muscle hypertrophy (HP:0008981)6.06518462
8Distal arthrogryposis (HP:0005684)5.55017988
9Type 1 muscle fiber predominance (HP:0003803)5.44606616
10Deep venous thrombosis (HP:0002625)5.11029045
11Hyporeflexia of lower limbs (HP:0002600)5.06278986
12Difficulty running (HP:0009046)4.99800101
13Myopathic facies (HP:0002058)4.82388000
14Muscle fiber splitting (HP:0003555)4.80999267
15Round ear (HP:0100830)4.71194710
16Abnormality of the calf musculature (HP:0001430)4.65630394
17Myoglobinuria (HP:0002913)4.50882578
18EMG: myopathic abnormalities (HP:0003458)4.41318288
19Myotonia (HP:0002486)4.28087722
20Prolonged partial thromboplastin time (HP:0003645)4.24819235
21Ulnar deviation of the wrist (HP:0003049)4.18047126
22Muscle stiffness (HP:0003552)4.07417703
23Sudden death (HP:0001699)4.06766552
24Hypobetalipoproteinemia (HP:0003563)3.88371321
25Increased connective tissue (HP:0009025)3.76445587
26Absent phalangeal crease (HP:0006109)3.64017237
27Calcaneovalgus deformity (HP:0001848)3.44741828
28Abnormality of the left ventricular outflow tract (HP:0011103)3.43969628
29Subaortic stenosis (HP:0001682)3.43969628
30Abnormality of skeletal muscle fiber size (HP:0012084)3.40449354
31Increased variability in muscle fiber diameter (HP:0003557)3.35054425
32Hypolipoproteinemia (HP:0010981)3.33226650
33Difficulty climbing stairs (HP:0003551)3.32029144
34Rhabdomyolysis (HP:0003201)3.31464361
35Deformed tarsal bones (HP:0008119)3.17224482
36Abnormality of the common coagulation pathway (HP:0010990)3.11460317
37Rimmed vacuoles (HP:0003805)3.09382098
38Abnormal finger flexion creases (HP:0006143)3.08191997
39Shoulder girdle muscle weakness (HP:0003547)2.99891328
40Hypoalphalipoproteinemia (HP:0003233)2.97432649
41Joint hemorrhage (HP:0005261)2.96824911
42Areflexia of lower limbs (HP:0002522)2.94768705
43Neck muscle weakness (HP:0000467)2.90375434
44Complement deficiency (HP:0004431)2.83824727
45Pelvic girdle muscle weakness (HP:0003749)2.80128025
46Abnormality of the hip-girdle musculature (HP:0001445)2.79513673
47Abnormality of the musculature of the pelvis (HP:0001469)2.79513673
48Focal motor seizures (HP:0011153)2.78232007
49Asymmetric septal hypertrophy (HP:0001670)2.77092637
50Hyperkalemia (HP:0002153)2.75800776
51Distal lower limb muscle weakness (HP:0009053)2.65625941
52Malignant hyperthermia (HP:0002047)2.61494251
53Abnormality of monocarboxylic acid metabolism (HP:0010996)2.59919929
54Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.55238964
55Frequent falls (HP:0002359)2.49486021
56EMG: neuropathic changes (HP:0003445)2.48583844
57Ventricular tachycardia (HP:0004756)2.47995403
58Muscular dystrophy (HP:0003560)2.46432213
59Bundle branch block (HP:0011710)2.39236152
60Visual hallucinations (HP:0002367)2.36477452
61Hepatoblastoma (HP:0002884)2.36211545
62Hypercholesterolemia (HP:0003124)2.31341467
63Distal lower limb amyotrophy (HP:0008944)2.31306416
64Papillary thyroid carcinoma (HP:0002895)2.27899791
65Lower limb amyotrophy (HP:0007210)2.27343581
66Xanthomatosis (HP:0000991)2.26878493
67Increased serum pyruvate (HP:0003542)2.25845683
68Mildly elevated creatine phosphokinase (HP:0008180)2.25513892
69Atrial fibrillation (HP:0005110)2.25093034
70Spontaneous abortion (HP:0005268)2.23151670
71Abnormality of the neuromuscular junction (HP:0003398)2.22283084
72Fatigable weakness (HP:0003473)2.22283084
73Prolonged QT interval (HP:0001657)2.21138852
74Fetal akinesia sequence (HP:0001989)2.19809548
75Proximal amyotrophy (HP:0007126)2.18243484
76Primary atrial arrhythmia (HP:0001692)2.17357380
77Abnormality of aromatic amino acid family metabolism (HP:0004338)2.17156891
78Acanthocytosis (HP:0001927)2.16343609
79Gowers sign (HP:0003391)2.14557642
80Limb-girdle muscle atrophy (HP:0003797)2.14454619
81Scapular winging (HP:0003691)2.10530682
82Limb-girdle muscle weakness (HP:0003325)2.08894345
83Hypoplastic ischia (HP:0003175)2.08031977
84Supraventricular tachycardia (HP:0004755)2.04417298
85Broad-based gait (HP:0002136)2.04006664
86Focal seizures (HP:0007359)2.03173849
87Abnormality of glycolysis (HP:0004366)2.03139146
88Lipoatrophy (HP:0100578)2.00310842
89Supraventricular arrhythmia (HP:0005115)1.99941153
90Abnormality of the calcaneus (HP:0008364)1.99856165
91Facial diplegia (HP:0001349)1.99764567
92Abnormality of the shoulder girdle musculature (HP:0001435)1.99332246
93Abnormality of complement system (HP:0005339)1.96387257
94Slender build (HP:0001533)1.95732458
95Foot dorsiflexor weakness (HP:0009027)1.92597859
96Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.92210783
97Centrally nucleated skeletal muscle fibers (HP:0003687)1.91026824
98Syncope (HP:0001279)1.90832261
99Hyperlipoproteinemia (HP:0010980)1.89382002
100Ventricular arrhythmia (HP:0004308)1.89327734
101Myokymia (HP:0002411)1.89165241
102Popliteal pterygium (HP:0009756)1.88933101
103Intrahepatic cholestasis (HP:0001406)1.88495421
104Pheochromocytoma (HP:0002666)1.87918149
105Right ventricular cardiomyopathy (HP:0011663)1.86381355
106Generalized muscle weakness (HP:0003324)1.86298103
107Abnormality of the foot musculature (HP:0001436)1.85665990
108Abnormality of the ischium (HP:0003174)1.84729782
109Atonic seizures (HP:0010819)1.83705282
110Back pain (HP:0003418)1.83695915
111Abnormality of the intrinsic pathway (HP:0010989)1.82786693
112Limited hip movement (HP:0008800)1.81865471
113Steppage gait (HP:0003376)1.81108182
114Spinal rigidity (HP:0003306)1.80977330
115Mitral stenosis (HP:0001718)1.80846763
116Nonprogressive disorder (HP:0003680)1.79796180
117Abnormal EKG (HP:0003115)1.78265233
118Urinary urgency (HP:0000012)1.75953967
119Ventricular fibrillation (HP:0001663)1.75252732
120Epidermoid cyst (HP:0200040)1.74127181
121Heart block (HP:0012722)1.73919086
122Ulnar deviation of finger (HP:0009465)1.73828099
123Bulbar palsy (HP:0001283)1.73379414
124Pterygium (HP:0001059)1.73016839
125Dilated cardiomyopathy (HP:0001644)1.71341286
126Febrile seizures (HP:0002373)1.70914502
127Hyperglycinuria (HP:0003108)1.70233963
128Urinary bladder sphincter dysfunction (HP:0002839)1.70141983
129Achilles tendon contracture (HP:0001771)1.69565893
130Palpitations (HP:0001962)1.68973615
131Pancreatic islet-cell hyperplasia (HP:0004510)1.66260107
132Impaired pain sensation (HP:0007328)1.65310556
133Abnormality of pain sensation (HP:0010832)1.65310556
134Vascular calcification (HP:0004934)1.64797731
135Menorrhagia (HP:0000132)1.63192774
136Gout (HP:0001997)1.60515338
137Protrusio acetabuli (HP:0003179)1.57651711
138Cardiovascular calcification (HP:0011915)1.56973319
139Proximal tubulopathy (HP:0000114)1.55820276
140Abnormal delivery (HP:0001787)1.55546867
141Osteomalacia (HP:0002749)1.54241954
142Asymmetry of the thorax (HP:0001555)1.53698234
143Glomerulonephritis (HP:0000099)1.53488568
144Fat malabsorption (HP:0002630)1.50936435

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN5.79669036
2PHKG24.91784788
3PHKG14.91784788
4TTN4.63651662
5NME12.99441385
6LATS12.78690007
7FGFR42.32319118
8DMPK2.30781067
9MAP3K92.19417444
10NTRK32.15732207
11MAP2K41.98670139
12PDK31.97731927
13PDK41.97731927
14FGFR31.92794749
15EEF2K1.86845772
16NEK11.78182945
17EPHA41.76083742
18MARK11.74187312
19PIK3CA1.67659868
20PINK11.65896980
21PIK3CG1.58584435
22MAP3K71.58290800
23MAP3K41.57864598
24MUSK1.50371809
25BCR1.50128545
26BRD41.49877892
27MINK11.49787179
28KSR21.36022432
29MAP2K31.33201444
30FGFR11.32622080
31TNIK1.31272158
32TAOK21.27427689
33MAPK121.23159583
34ICK1.22239599
35PAK61.20780167
36TRIB31.15295687
37LMTK21.15003003
38MAP3K101.05291024
39FGFR21.05029482
40DAPK21.04896190
41PDK21.04382627
42NEK91.03730686
43WNK31.02865628
44LATS21.02840228
45CDK121.01173251
46PRKD30.97431999
47DYRK1B0.95495853
48TYRO30.95112668
49MET0.95027185
50MAP2K60.93178835
51KSR10.93152743
52PLK20.88373661
53PNCK0.87291022
54PTK2B0.86956624
55STK240.85598023
56MAP2K70.84147360
57MAPKAPK30.83266891
58ERBB30.83183887
59STK380.82334869
60NTRK10.82040625
61PBK0.79128235
62MAPK130.78515507
63MYLK0.77363723
64RPS6KB10.76774778
65WNK10.74935556
66CAMKK10.74728890
67EPHA30.72797077
68SGK10.71970069
69PRKAA10.71704432
70RET0.71454459
71ERBB40.69719329
72CAMK1G0.66442962
73ACVR1B0.66240346
74CAMK2A0.64978059
75DDR20.64970999
76MAP3K20.63261119
77PAK30.63045649
78RIPK10.63000082
79CDK50.62942219
80LIMK10.62422285
81TAOK10.62370278
82CAMK2D0.61416797
83MAP3K120.60946347
84MAP3K10.60525895
85GRK50.60426086
86ROCK10.59744339
87NTRK20.57888690
88CAMK2G0.57416235
89RIPK40.57412150
90TTK0.56736650
91SGK20.56326564
92CAMKK20.55378019
93SGK30.55334937
94CSNK1E0.55265448
95PRKAA20.54711440
96CDC42BPA0.54356425
97STK38L0.54066610
98STK30.53212149
99CASK0.51549758
100RPS6KA20.51379312
101MTOR0.50895406
102PKN20.49182663
103FER0.48707173
104PDGFRB0.48240762
105EIF2AK30.47615368
106ERBB20.46652505
107RPS6KA30.45412734
108MAP2K10.45335741
109CAMK10.45301585
110SGK4940.45231567
111SGK2230.45231567
112PRKG10.44353324
113STK110.44311633
114PKN10.43049627
115PDPK10.42138287
116CAMK40.41899032
117MAP3K50.41744411
118PDK10.40860872
119FLT30.40150362
120PRKCH0.39768760
121PRKACG0.39340285
122ZAK0.39269005
123MAP3K60.38829516
124PRKACB0.38473881
125ILK0.38120537
126PRKG20.37999346
127YES10.35713416
128TRIM280.35698937
129PRKCG0.35417967
130TRPM70.34657141
131MAPK110.34607727
132PRKACA0.34547779
133DYRK1A0.34347100
134CSNK1D0.34328799
135PRKD10.33450251
136PDGFRA0.33118637
137AKT30.32654370
138ROCK20.31795739
139MAPK100.31233129
140SIK20.28447935
141AKT20.27960969

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042603.04131570
2Dilated cardiomyopathy_Homo sapiens_hsa054142.83622463
3* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.80526345
4Complement and coagulation cascades_Homo sapiens_hsa046102.78538751
5Arginine biosynthesis_Homo sapiens_hsa002202.57344162
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.54250195
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.35618920
8Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.25170515
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.15587123
10* Oxytocin signaling pathway_Homo sapiens_hsa049212.14274822
11Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.10092508
12Fatty acid degradation_Homo sapiens_hsa000712.07999745
13Circadian entrainment_Homo sapiens_hsa047131.97751612
14Calcium signaling pathway_Homo sapiens_hsa040201.93834233
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.93592659
16Long-term potentiation_Homo sapiens_hsa047201.90327892
17Nicotine addiction_Homo sapiens_hsa050331.89789650
18Olfactory transduction_Homo sapiens_hsa047401.75526175
19Synaptic vesicle cycle_Homo sapiens_hsa047211.73432981
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.71217232
21Gastric acid secretion_Homo sapiens_hsa049711.70193419
22Insulin secretion_Homo sapiens_hsa049111.69412616
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.62382222
24Arginine and proline metabolism_Homo sapiens_hsa003301.62246427
25Phenylalanine metabolism_Homo sapiens_hsa003601.60293929
26Pyruvate metabolism_Homo sapiens_hsa006201.59893999
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.58704710
28Fat digestion and absorption_Homo sapiens_hsa049751.57686609
29Renin secretion_Homo sapiens_hsa049241.57289390
30Biosynthesis of amino acids_Homo sapiens_hsa012301.57095801
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.56041620
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.55027619
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.53841454
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.53624155
35Amphetamine addiction_Homo sapiens_hsa050311.53358047
36GABAergic synapse_Homo sapiens_hsa047271.52508070
37PPAR signaling pathway_Homo sapiens_hsa033201.51936621
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.51639346
39Cholinergic synapse_Homo sapiens_hsa047251.49140454
40Retinol metabolism_Homo sapiens_hsa008301.48323000
41GnRH signaling pathway_Homo sapiens_hsa049121.47743925
42Dopaminergic synapse_Homo sapiens_hsa047281.47179549
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.46528663
44Histidine metabolism_Homo sapiens_hsa003401.44357195
45Glutamatergic synapse_Homo sapiens_hsa047241.43762762
46Fatty acid metabolism_Homo sapiens_hsa012121.42448547
47* Glucagon signaling pathway_Homo sapiens_hsa049221.42345575
48Alzheimers disease_Homo sapiens_hsa050101.38833141
49Morphine addiction_Homo sapiens_hsa050321.38720870
50Salivary secretion_Homo sapiens_hsa049701.34265799
51* Insulin signaling pathway_Homo sapiens_hsa049101.33593241
52Vascular smooth muscle contraction_Homo sapiens_hsa042701.33510980
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31488818
54Bile secretion_Homo sapiens_hsa049761.30939449
55Parkinsons disease_Homo sapiens_hsa050121.30875268
56Butanoate metabolism_Homo sapiens_hsa006501.30399518
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24948368
58Long-term depression_Homo sapiens_hsa047301.23695586
59Oxidative phosphorylation_Homo sapiens_hsa001901.20604632
60Type II diabetes mellitus_Homo sapiens_hsa049301.19366951
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.18086220
62Taste transduction_Homo sapiens_hsa047421.15050685
63Chemical carcinogenesis_Homo sapiens_hsa052041.14146138
64Vitamin digestion and absorption_Homo sapiens_hsa049771.13544704
65Caffeine metabolism_Homo sapiens_hsa002321.12736351
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.12065423
67Dorso-ventral axis formation_Homo sapiens_hsa043201.12038676
68Tyrosine metabolism_Homo sapiens_hsa003501.11193006
69Serotonergic synapse_Homo sapiens_hsa047261.10600577
70* Circadian rhythm_Homo sapiens_hsa047101.06538484
71cAMP signaling pathway_Homo sapiens_hsa040241.03336798
72Steroid hormone biosynthesis_Homo sapiens_hsa001401.03139178
73Gap junction_Homo sapiens_hsa045400.99491289
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98229503
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96463605
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93690971
77MAPK signaling pathway_Homo sapiens_hsa040100.93360508
78* Insulin resistance_Homo sapiens_hsa049310.93251131
79mTOR signaling pathway_Homo sapiens_hsa041500.90682353
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88951283
81Tight junction_Homo sapiens_hsa045300.88263082
82Lysine degradation_Homo sapiens_hsa003100.87251145
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86508928
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86401220
85Focal adhesion_Homo sapiens_hsa045100.85970197
86Melanogenesis_Homo sapiens_hsa049160.84849506
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.84162948
88Glioma_Homo sapiens_hsa052140.83014761
89Viral myocarditis_Homo sapiens_hsa054160.82473867
90* AMPK signaling pathway_Homo sapiens_hsa041520.82320203
91Steroid biosynthesis_Homo sapiens_hsa001000.81725996
92VEGF signaling pathway_Homo sapiens_hsa043700.81604558
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79800219
94ErbB signaling pathway_Homo sapiens_hsa040120.79255008
95Cocaine addiction_Homo sapiens_hsa050300.78645886
96ECM-receptor interaction_Homo sapiens_hsa045120.78322103
97beta-Alanine metabolism_Homo sapiens_hsa004100.77067075
98Estrogen signaling pathway_Homo sapiens_hsa049150.76915394
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.76397915
100Starch and sucrose metabolism_Homo sapiens_hsa005000.75939068
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75778459
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.75317535
103Pentose phosphate pathway_Homo sapiens_hsa000300.75117580
104Huntingtons disease_Homo sapiens_hsa050160.74206956
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73978957
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.72687791
107Axon guidance_Homo sapiens_hsa043600.72329571
108Peroxisome_Homo sapiens_hsa041460.72002084
109* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70523109
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.69307585
111* Adipocytokine signaling pathway_Homo sapiens_hsa049200.68233787
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67741406
113Fatty acid biosynthesis_Homo sapiens_hsa000610.66377502
114Renal cell carcinoma_Homo sapiens_hsa052110.65665959
115* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64904753
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63268561
117HIF-1 signaling pathway_Homo sapiens_hsa040660.63048912
118* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61576411
119Fatty acid elongation_Homo sapiens_hsa000620.60116112
120Carbon metabolism_Homo sapiens_hsa012000.59772301
121Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59641411
122Pancreatic secretion_Homo sapiens_hsa049720.59580187
123Tryptophan metabolism_Homo sapiens_hsa003800.58689950
124Fructose and mannose metabolism_Homo sapiens_hsa000510.58493171
125Oocyte meiosis_Homo sapiens_hsa041140.57918952
126Propanoate metabolism_Homo sapiens_hsa006400.57268867
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56990894
128ABC transporters_Homo sapiens_hsa020100.56466861
129Renin-angiotensin system_Homo sapiens_hsa046140.55868792
130Collecting duct acid secretion_Homo sapiens_hsa049660.54431043
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54187928
132TGF-beta signaling pathway_Homo sapiens_hsa043500.53823738
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53502387
134Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52440036
135Prion diseases_Homo sapiens_hsa050200.52111006
136Choline metabolism in cancer_Homo sapiens_hsa052310.51667501
137Platelet activation_Homo sapiens_hsa046110.51566624
138Phospholipase D signaling pathway_Homo sapiens_hsa040720.51411627
139Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50720407
140Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49317029
141* FoxO signaling pathway_Homo sapiens_hsa040680.49183158
142Proteoglycans in cancer_Homo sapiens_hsa052050.48826895
143Thyroid cancer_Homo sapiens_hsa052160.47568988
144Galactose metabolism_Homo sapiens_hsa000520.45031696
145Amoebiasis_Homo sapiens_hsa051460.44174250
146Thyroid hormone synthesis_Homo sapiens_hsa049180.43664454
147Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43497025
148Phototransduction_Homo sapiens_hsa047440.42559197
149Protein digestion and absorption_Homo sapiens_hsa049740.42462156
150Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42031407
151Adherens junction_Homo sapiens_hsa045200.41793167
152Ras signaling pathway_Homo sapiens_hsa040140.41037735
153Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40773432
154Rap1 signaling pathway_Homo sapiens_hsa040150.40157789
155Wnt signaling pathway_Homo sapiens_hsa043100.39442484
156Hippo signaling pathway_Homo sapiens_hsa043900.39194132
157Endometrial cancer_Homo sapiens_hsa052130.37362196
158Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36671878
159Vitamin B6 metabolism_Homo sapiens_hsa007500.34270969
160mRNA surveillance pathway_Homo sapiens_hsa030150.29192526
161Nitrogen metabolism_Homo sapiens_hsa009100.26835087
162Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.25608614
163Maturity onset diabetes of the young_Homo sapiens_hsa049500.25267977

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