PRKACB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.56302402
2synaptic vesicle maturation (GO:0016188)5.53177781
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.27668950
4synaptic vesicle exocytosis (GO:0016079)5.14233276
5regulation of synaptic vesicle exocytosis (GO:2000300)5.04823578
6locomotory exploration behavior (GO:0035641)4.97958883
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.77187561
8glutamate secretion (GO:0014047)4.77182387
9vocalization behavior (GO:0071625)4.62308033
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.56940697
11neuron cell-cell adhesion (GO:0007158)4.40956491
12cerebellar granule cell differentiation (GO:0021707)4.37185271
13regulation of synaptic vesicle transport (GO:1902803)4.36780241
14regulation of glutamate receptor signaling pathway (GO:1900449)4.35934682
15nerve growth factor signaling pathway (GO:0038180)4.30044961
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.26146575
17neurotransmitter secretion (GO:0007269)4.22967993
18neuronal action potential propagation (GO:0019227)4.19340467
19protein localization to synapse (GO:0035418)4.14528380
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.94349121
21ionotropic glutamate receptor signaling pathway (GO:0035235)3.89612824
22regulation of neuronal synaptic plasticity (GO:0048168)3.88243000
23regulation of long-term neuronal synaptic plasticity (GO:0048169)3.87776038
24exploration behavior (GO:0035640)3.85204866
25layer formation in cerebral cortex (GO:0021819)3.83690184
26positive regulation of synapse maturation (GO:0090129)3.78618915
27regulation of synapse structural plasticity (GO:0051823)3.76222139
28L-amino acid import (GO:0043092)3.75193586
29gamma-aminobutyric acid transport (GO:0015812)3.67745484
30negative regulation of neurotransmitter secretion (GO:0046929)3.66267102
31neuron-neuron synaptic transmission (GO:0007270)3.62390851
32dendritic spine morphogenesis (GO:0060997)3.60885487
33cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.60777944
34positive regulation of synaptic transmission, GABAergic (GO:0032230)3.59365472
35proline transport (GO:0015824)3.58148539
36synaptic transmission, glutamatergic (GO:0035249)3.58043229
37neurotransmitter-gated ion channel clustering (GO:0072578)3.57809190
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.56819478
39neurotransmitter transport (GO:0006836)3.51260870
40glutamate receptor signaling pathway (GO:0007215)3.47501795
41presynaptic membrane assembly (GO:0097105)3.45745970
42long-term memory (GO:0007616)3.40735667
43positive regulation of membrane potential (GO:0045838)3.39509950
44gamma-aminobutyric acid signaling pathway (GO:0007214)3.38973430
45neuron recognition (GO:0008038)3.38949224
46neuromuscular process controlling posture (GO:0050884)3.33634356
47auditory behavior (GO:0031223)3.33382395
48regulation of voltage-gated calcium channel activity (GO:1901385)3.33288962
49regulation of excitatory postsynaptic membrane potential (GO:0060079)3.32767778
50cellular potassium ion homeostasis (GO:0030007)3.32060322
51potassium ion import (GO:0010107)3.31947028
52transmission of nerve impulse (GO:0019226)3.30524461
53presynaptic membrane organization (GO:0097090)3.29617281
54negative regulation of dendrite morphogenesis (GO:0050774)3.27065581
55neurotransmitter uptake (GO:0001504)3.27014330
56* activation of protein kinase A activity (GO:0034199)3.25963927
57regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.25940324
58long-term synaptic potentiation (GO:0060291)3.25308774
59vesicle transport along microtubule (GO:0047496)3.24758719
60regulation of neurotransmitter secretion (GO:0046928)3.24634524
61regulation of neurotransmitter levels (GO:0001505)3.22481077
62regulation of postsynaptic membrane potential (GO:0060078)3.21016797
63negative regulation of synaptic transmission, GABAergic (GO:0032229)3.20451289
64postsynaptic membrane organization (GO:0001941)3.20221855
65regulation of vesicle fusion (GO:0031338)3.18001185
66regulation of clathrin-mediated endocytosis (GO:2000369)3.16022441
67regulation of synaptic plasticity (GO:0048167)3.14041736
68detection of calcium ion (GO:0005513)3.13724682
69amino acid import (GO:0043090)3.12454134
70regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.12133702
71positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.11586219
72response to auditory stimulus (GO:0010996)3.10583788
73positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.10313993
74negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.10021718
75potassium ion homeostasis (GO:0055075)3.09958144
76positive regulation of dendritic spine development (GO:0060999)3.08156513
77regulation of synaptic transmission, glutamatergic (GO:0051966)3.08118153
78regulation of neurotransmitter transport (GO:0051588)3.05283814
79positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.04779299
80cerebellar Purkinje cell differentiation (GO:0021702)3.03615675
81regulation of synapse maturation (GO:0090128)3.03233169
82mechanosensory behavior (GO:0007638)3.02997179
83dendrite morphogenesis (GO:0048813)3.01281991
84cell differentiation in hindbrain (GO:0021533)3.01066347
85glycine transport (GO:0015816)3.00897436
86synaptic vesicle endocytosis (GO:0048488)2.99731282
87cellular sodium ion homeostasis (GO:0006883)2.99201459
88organelle transport along microtubule (GO:0072384)2.99129366
89positive regulation of Rap GTPase activity (GO:0032854)2.98851842
90neuromuscular process controlling balance (GO:0050885)2.98564101
91prepulse inhibition (GO:0060134)2.98536393
92axonal fasciculation (GO:0007413)2.98299019
93cell communication by electrical coupling (GO:0010644)2.97974772
94vesicle docking involved in exocytosis (GO:0006904)2.97923311
95cerebellar Purkinje cell layer development (GO:0021680)2.96554520
96regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.96066708
97mating behavior (GO:0007617)2.95291322
98negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.94901603
99response to histamine (GO:0034776)2.94379311
100acidic amino acid transport (GO:0015800)2.94138180
101regulation of synaptic transmission, GABAergic (GO:0032228)2.93931959
102synapse assembly (GO:0007416)2.93186039
103dendritic spine organization (GO:0097061)2.93053290
104neuronal ion channel clustering (GO:0045161)2.92650821
105G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.91968540
106regulation of dendritic spine morphogenesis (GO:0061001)2.90828386
107positive regulation of neurotransmitter transport (GO:0051590)2.90313687
108startle response (GO:0001964)2.89183051
109regulation of dendritic spine development (GO:0060998)2.88420250
110regulation of cell communication by electrical coupling (GO:0010649)2.88243190
111regulation of Rap GTPase activity (GO:0032317)2.87528189
112membrane hyperpolarization (GO:0060081)2.86568481
113relaxation of smooth muscle (GO:0044557)2.85698535
114serotonin metabolic process (GO:0042428)2.84146350
115sleep (GO:0030431)2.83881839
116regulation of calcium ion-dependent exocytosis (GO:0017158)2.83440672
117membrane depolarization (GO:0051899)2.82495400
118adult walking behavior (GO:0007628)2.81939210
119positive regulation of synaptic transmission (GO:0050806)2.81887976
120sodium ion export (GO:0071436)2.81742639
121negative regulation of neurotransmitter transport (GO:0051589)2.81703498
122membrane depolarization during action potential (GO:0086010)2.81583921
123vesicle docking (GO:0048278)2.81434214
124positive regulation of dendritic spine morphogenesis (GO:0061003)2.79880906
125axon ensheathment in central nervous system (GO:0032291)2.79440845
126positive regulation of neurotransmitter secretion (GO:0001956)2.77327990
127* synaptic transmission (GO:0007268)2.77258674
128calcium ion-dependent exocytosis (GO:0017156)2.75118826
129learning (GO:0007612)2.75005610
130regulation of synaptic transmission (GO:0050804)2.74693199
131regulation of exocytosis (GO:0017157)2.74663264
132regulation of ARF protein signal transduction (GO:0032012)2.74044855
133suckling behavior (GO:0001967)2.73110287
134innervation (GO:0060384)2.72954748

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.31836819
2GBX2_23144817_ChIP-Seq_PC3_Human3.58351311
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.01793694
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.91516977
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.79383262
6REST_21632747_ChIP-Seq_MESCs_Mouse2.70443262
7* RARB_27405468_Chip-Seq_BRAIN_Mouse2.55443552
8SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.48969895
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45975503
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43352958
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41293888
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.41261726
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.41261726
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.40233626
15DROSHA_22980978_ChIP-Seq_HELA_Human2.37449818
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.32138804
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29659550
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.22534657
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11207613
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.10635670
21TAF15_26573619_Chip-Seq_HEK293_Human2.09566047
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.08596054
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.07291706
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.04745978
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.01165598
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.99574917
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92093739
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.89005077
29AR_21572438_ChIP-Seq_LNCaP_Human1.86233829
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.78792758
31SMAD4_21799915_ChIP-Seq_A2780_Human1.73360409
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67502477
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.67169748
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58667093
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58199882
36NR3C1_23031785_ChIP-Seq_PC12_Mouse1.51345930
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51088341
38P300_19829295_ChIP-Seq_ESCs_Human1.46245784
39ZNF274_21170338_ChIP-Seq_K562_Hela1.44187517
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43072660
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42859719
42SOX2_21211035_ChIP-Seq_LN229_Gbm1.41179125
43* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41029348
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38633574
45* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37193592
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.36693248
47IGF1R_20145208_ChIP-Seq_DFB_Human1.35352000
48* STAT3_23295773_ChIP-Seq_U87_Human1.34420199
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.30697836
50* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29875356
51GATA1_22025678_ChIP-Seq_K562_Human1.29748578
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.28826688
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.27731564
54* AR_25329375_ChIP-Seq_VCAP_Human1.24999750
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24784570
56* SCL_19346495_ChIP-Seq_HPC-7_Human1.24765164
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24749100
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.24001822
59STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.22257956
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22230893
61SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22062033
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21836310
63AR_19668381_ChIP-Seq_PC3_Human1.19409025
64TCF4_23295773_ChIP-Seq_U87_Human1.18222040
65BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17535093
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16665344
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16403511
68* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16238504
69WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14955635
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14581818
71DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13490983
72RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13321982
73RING1B_27294783_Chip-Seq_ESCs_Mouse1.12008816
74VDR_22108803_ChIP-Seq_LS180_Human1.11643287
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.10301291
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08993123
77TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08390274
78YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08153709
79RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08136503
80P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07976247
81P53_22387025_ChIP-Seq_ESCs_Mouse1.07376785
82CBX2_27304074_Chip-Seq_ESCs_Mouse1.06433071
83RUNX_20019798_ChIP-Seq_JUKART_Human1.06062483
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05788542
85AHR_22903824_ChIP-Seq_MCF-7_Human1.04691617
86CMYC_18555785_Chip-Seq_ESCs_Mouse1.04600065
87ER_23166858_ChIP-Seq_MCF-7_Human1.03775566
88RNF2_27304074_Chip-Seq_NSC_Mouse1.03163597
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02604711
90RUNX2_22187159_ChIP-Seq_PCA_Human1.02322149
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01780630
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01320073
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01182210
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00357167
95NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00357167
96E2F1_18555785_Chip-Seq_ESCs_Mouse0.98678068
97RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98200603
98NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98040291
99SMAD3_21741376_ChIP-Seq_ESCs_Human0.97926999
100* PRDM14_20953172_ChIP-Seq_ESCs_Human0.97216488
101FUS_26573619_Chip-Seq_HEK293_Human0.96578297
102GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96570892
103* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96448877
104RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96357732
105KDM2B_26808549_Chip-Seq_REH_Human0.95474438
106CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94765245
107FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.94344158
108* TAL1_26923725_Chip-Seq_HPCs_Mouse0.93502777
109RING1B_27294783_Chip-Seq_NPCs_Mouse0.92757966
110WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92633490
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92065271
112TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91519964
113SMAD4_21741376_ChIP-Seq_HESCs_Human0.91163180
114PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90713737
115* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90644853
116* NANOG_18555785_Chip-Seq_ESCs_Mouse0.87221218
117* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87052100
118FLI1_21867929_ChIP-Seq_TH2_Mouse0.86526965
119ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.86229029
120TP53_16413492_ChIP-PET_HCT116_Human0.86195878
121LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86059997
122JUN_21703547_ChIP-Seq_K562_Human0.85815110
123EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.85481702
124ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85329713

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.58800369
2MP0003880_abnormal_central_pattern4.52656195
3* MP0003635_abnormal_synaptic_transmissio3.91263424
4MP0004270_analgesia3.74413778
5MP0009745_abnormal_behavioral_response3.27708895
6MP0002064_seizures3.12716404
7* MP0002063_abnormal_learning/memory/cond3.07557694
8MP0009046_muscle_twitch2.96103488
9MP0001968_abnormal_touch/_nociception2.78524421
10MP0002822_catalepsy2.76555700
11MP0002572_abnormal_emotion/affect_behav2.74252360
12MP0005423_abnormal_somatic_nervous2.66759160
13MP0002734_abnormal_mechanical_nocicepti2.61195303
14MP0002272_abnormal_nervous_system2.58661381
15MP0009780_abnormal_chondrocyte_physiolo2.57154475
16MP0001486_abnormal_startle_reflex2.47156090
17MP0002909_abnormal_adrenal_gland2.39290470
18MP0001501_abnormal_sleep_pattern2.13780307
19MP0002733_abnormal_thermal_nociception2.07754131
20MP0002736_abnormal_nociception_after2.06435777
21MP0001970_abnormal_pain_threshold2.01276243
22MP0001440_abnormal_grooming_behavior2.01066795
23MP0005646_abnormal_pituitary_gland1.99621437
24MP0002735_abnormal_chemical_nociception1.94784751
25MP0002067_abnormal_sensory_capabilities1.92874002
26MP0003329_amyloid_beta_deposits1.89244862
27MP0005386_behavior/neurological_phenoty1.88523805
28MP0004924_abnormal_behavior1.88523805
29MP0003122_maternal_imprinting1.84080754
30MP0008569_lethality_at_weaning1.83986132
31MP0001529_abnormal_vocalization1.78022030
32MP0005645_abnormal_hypothalamus_physiol1.76456800
33MP0006276_abnormal_autonomic_nervous1.76432528
34MP0000013_abnormal_adipose_tissue1.74266214
35MP0002557_abnormal_social/conspecific_i1.70517105
36MP0004811_abnormal_neuron_physiology1.66944955
37MP0000778_abnormal_nervous_system1.65359220
38MP0002184_abnormal_innervation1.59878802
39MP0000955_abnormal_spinal_cord1.56013842
40MP0003787_abnormal_imprinting1.55169779
41MP0001905_abnormal_dopamine_level1.43592349
42MP0004885_abnormal_endolymph1.42474158
43MP0001984_abnormal_olfaction1.41412881
44MP0002066_abnormal_motor_capabilities/c1.41028104
45MP0003879_abnormal_hair_cell1.40415005
46MP0004142_abnormal_muscle_tone1.39413346
47* MP0003633_abnormal_nervous_system1.38409676
48MP0002882_abnormal_neuron_morphology1.34766239
49MP0001502_abnormal_circadian_rhythm1.34441958
50MP0010386_abnormal_urinary_bladder1.34273895
51MP0004043_abnormal_pH_regulation1.33572629
52MP0004147_increased_porphyrin_level1.32813220
53MP0004858_abnormal_nervous_system1.31062629
54MP0003283_abnormal_digestive_organ1.25826296
55MP0000920_abnormal_myelination1.25719056
56MP0002837_dystrophic_cardiac_calcinosis1.21316538
57MP0008877_abnormal_DNA_methylation1.20078059
58MP0002009_preneoplasia1.13081131
59* MP0003631_nervous_system_phenotype1.12417909
60MP0002229_neurodegeneration1.12410185
61MP0003690_abnormal_glial_cell1.09077213
62MP0003634_abnormal_glial_cell1.07060628
63MP0003183_abnormal_peptide_metabolism1.06694890
64MP0004130_abnormal_muscle_cell1.03895329
65MP0005535_abnormal_body_temperature1.01405282
66MP0002152_abnormal_brain_morphology1.00645909
67MP0001188_hyperpigmentation0.99622958
68MP0008961_abnormal_basal_metabolism0.98625520
69MP0000631_abnormal_neuroendocrine_gland0.97910023
70MP0002069_abnormal_eating/drinking_beha0.96879599
71MP0005464_abnormal_platelet_physiology0.96537363
72MP0004145_abnormal_muscle_electrophysio0.94665571
73MP0003172_abnormal_lysosome_physiology0.90681495
74MP0005551_abnormal_eye_electrophysiolog0.89730856
75MP0000569_abnormal_digit_pigmentation0.87836381
76MP0004742_abnormal_vestibular_system0.87495876
77MP0000604_amyloidosis0.86883405
78MP0004085_abnormal_heartbeat0.86131939
79MP0006072_abnormal_retinal_apoptosis0.85703909
80MP0005379_endocrine/exocrine_gland_phen0.84596142
81MP0002090_abnormal_vision0.84396871
82MP0008872_abnormal_physiological_respon0.84237817
83MP0000465_gastrointestinal_hemorrhage0.83977069
84MP0005167_abnormal_blood-brain_barrier0.82932360
85MP0005084_abnormal_gallbladder_morpholo0.82619287
86MP0008874_decreased_physiological_sensi0.82241568
87MP0000751_myopathy0.82026475
88MP0003632_abnormal_nervous_system0.80888612
89MP0002693_abnormal_pancreas_physiology0.80124703
90MP0001177_atelectasis0.79658910
91MP0005409_darkened_coat_color0.76370210
92MP0002876_abnormal_thyroid_physiology0.75516869
93MP0001348_abnormal_lacrimal_gland0.75112198
94MP0001963_abnormal_hearing_physiology0.74055578
95MP0001299_abnormal_eye_distance/0.73587484
96MP0004484_altered_response_of0.72750728
97MP0003123_paternal_imprinting0.72331875
98MP0003724_increased_susceptibility_to0.68683050
99MP0001944_abnormal_pancreas_morphology0.68381600
100MP0001664_abnormal_digestion0.67652322
101MP0000003_abnormal_adipose_tissue0.67565917
102MP0003866_abnormal_defecation0.67452638
103MP0002638_abnormal_pupillary_reflex0.66823002
104MP0002752_abnormal_somatic_nervous0.64551895
105MP0003763_abnormal_thymus_physiology0.64477141
106MP0002078_abnormal_glucose_homeostasis0.62712226
107MP0001986_abnormal_taste_sensitivity0.61610645
108MP0001485_abnormal_pinna_reflex0.61048733
109MP0003075_altered_response_to0.60872471
110MP0001943_abnormal_respiration0.60266580
111MP0001765_abnormal_ion_homeostasis0.55263860
112MP0000747_muscle_weakness0.54637339
113MP0003121_genomic_imprinting0.53929761
114MP0004215_abnormal_myocardial_fiber0.53797258
115MP0002083_premature_death0.53555965
116MP0010769_abnormal_survival0.53519918
117MP0005394_taste/olfaction_phenotype0.53453373
118MP0003956_abnormal_body_size0.51963465
119MP0010768_mortality/aging0.51029467

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.73432854
2Myokymia (HP:0002411)5.73155323
3Visual hallucinations (HP:0002367)5.10575384
4Focal seizures (HP:0007359)5.08931260
5Atonic seizures (HP:0010819)4.50434456
6Epileptic encephalopathy (HP:0200134)4.41950551
7Absence seizures (HP:0002121)3.98227865
8Papilledema (HP:0001085)3.93378339
9Supranuclear gaze palsy (HP:0000605)3.90121812
10Febrile seizures (HP:0002373)3.72002699
11Generalized tonic-clonic seizures (HP:0002069)3.67574719
12Dialeptic seizures (HP:0011146)3.65386432
13Progressive cerebellar ataxia (HP:0002073)3.55458702
14Ankle clonus (HP:0011448)3.45369903
15Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.33016069
16Action tremor (HP:0002345)3.29967219
17Pheochromocytoma (HP:0002666)3.29133544
18Neurofibrillary tangles (HP:0002185)3.27474789
19Depression (HP:0000716)3.24398833
20Broad-based gait (HP:0002136)3.15964465
21Anxiety (HP:0000739)3.15892481
22Poor eye contact (HP:0000817)3.12961426
23Truncal ataxia (HP:0002078)3.09362314
24Limb dystonia (HP:0002451)2.98972862
25Cerebral inclusion bodies (HP:0100314)2.96614226
26Abnormal eating behavior (HP:0100738)2.94856253
27Impaired vibration sensation in the lower limbs (HP:0002166)2.94835964
28Agitation (HP:0000713)2.94538302
29Urinary bladder sphincter dysfunction (HP:0002839)2.94326071
30Spastic gait (HP:0002064)2.93066567
31Mutism (HP:0002300)2.91678009
32Hyperventilation (HP:0002883)2.89473830
33Insidious onset (HP:0003587)2.88725716
34Termporal pattern (HP:0011008)2.88725716
35Dysmetria (HP:0001310)2.87551880
36Impaired social interactions (HP:0000735)2.84503091
37Abnormal social behavior (HP:0012433)2.84503091
38Neuroendocrine neoplasm (HP:0100634)2.83145357
39Progressive inability to walk (HP:0002505)2.82546657
40Abnormality of the corticospinal tract (HP:0002492)2.81522003
41Epileptiform EEG discharges (HP:0011182)2.78324588
42EEG with generalized epileptiform discharges (HP:0011198)2.74102481
43Tetraplegia (HP:0002445)2.73427642
44Drooling (HP:0002307)2.71657861
45Excessive salivation (HP:0003781)2.71657861
46Gaze-evoked nystagmus (HP:0000640)2.68905950
47Postural instability (HP:0002172)2.67586424
48Urinary urgency (HP:0000012)2.64473696
49Dysdiadochokinesis (HP:0002075)2.64398726
50Hypsarrhythmia (HP:0002521)2.63427834
51Diplopia (HP:0000651)2.57052181
52Abnormality of binocular vision (HP:0011514)2.57052181
53Scanning speech (HP:0002168)2.53570962
54Torticollis (HP:0000473)2.49284528
55Delusions (HP:0000746)2.47843864
56Obstructive sleep apnea (HP:0002870)2.44104042
57Degeneration of the lateral corticospinal tracts (HP:0002314)2.42064186
58Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.42064186
59Intention tremor (HP:0002080)2.41490418
60Impaired smooth pursuit (HP:0007772)2.40088988
61Morphological abnormality of the pyramidal tract (HP:0002062)2.36872215
62Hemiparesis (HP:0001269)2.35373165
63Amblyopia (HP:0000646)2.35178177
64Bradykinesia (HP:0002067)2.33462129
65Polyphagia (HP:0002591)2.32230003
66Resting tremor (HP:0002322)2.31480939
67Megalencephaly (HP:0001355)2.25822650
68Lower limb muscle weakness (HP:0007340)2.25347275
69Focal dystonia (HP:0004373)2.24565431
70Genetic anticipation (HP:0003743)2.24303409
71Neuronal loss in central nervous system (HP:0002529)2.23976909
72Cerebral hypomyelination (HP:0006808)2.21559450
73Failure to thrive in infancy (HP:0001531)2.20886594
74Menstrual irregularities (HP:0000858)2.18733972
75Blue irides (HP:0000635)2.17080887
76Stereotypic behavior (HP:0000733)2.14077329
77Choreoathetosis (HP:0001266)2.13852373
78Hemiplegia (HP:0002301)2.10540424
79Clonus (HP:0002169)2.09646262
80Generalized myoclonic seizures (HP:0002123)2.08672511
81Psychosis (HP:0000709)2.08151540
82Craniofacial dystonia (HP:0012179)2.07970649
83Bundle branch block (HP:0011710)2.04712304
84Sleep apnea (HP:0010535)2.04684097
85Amyotrophic lateral sclerosis (HP:0007354)2.04184534
86Abnormality of ocular smooth pursuit (HP:0000617)2.03801139
87Postural tremor (HP:0002174)2.03116915
88Inability to walk (HP:0002540)2.02780422
89Paraplegia (HP:0010550)2.02370471
90Abnormality of calcium-phosphate metabolism (HP:0100530)2.01049695
91Annular pancreas (HP:0001734)2.00802039
92Lower limb asymmetry (HP:0100559)1.99054877
93Absent speech (HP:0001344)1.96461635
94Gait imbalance (HP:0002141)1.95788426
95Memory impairment (HP:0002354)1.95246014
96Impaired vibratory sensation (HP:0002495)1.94656351
97Akinesia (HP:0002304)1.94626261
98Spastic tetraparesis (HP:0001285)1.93816664
99CNS hypomyelination (HP:0003429)1.93373587
100Dyskinesia (HP:0100660)1.92914915
101Neoplasm of the peripheral nervous system (HP:0100007)1.92846689
102Abnormality of the periventricular white matter (HP:0002518)1.91852852
103Gait ataxia (HP:0002066)1.91549983
104Slow saccadic eye movements (HP:0000514)1.91113993
105Increased circulating renin level (HP:0000848)1.90855827
106Spastic paraplegia (HP:0001258)1.90295957
107Rigidity (HP:0002063)1.89597135
108Hypoventilation (HP:0002791)1.85423170
109Spastic tetraplegia (HP:0002510)1.84233108
110Abnormality of the lower motor neuron (HP:0002366)1.83847219
111Inappropriate behavior (HP:0000719)1.83413655
112Abnormality of salivation (HP:0100755)1.82045594
113Diminished motivation (HP:0000745)1.81604672
114Macroorchidism (HP:0000053)1.81422834
115Status epilepticus (HP:0002133)1.81419936
116Specific learning disability (HP:0001328)1.78354232
117Protruding tongue (HP:0010808)1.77631758
118Dysmetric saccades (HP:0000641)1.77364795
119Fetal akinesia sequence (HP:0001989)1.75269070
120Insomnia (HP:0100785)1.73350137
121Abnormality of saccadic eye movements (HP:0000570)1.71951764
122Abnormal hair whorl (HP:0010721)1.71777738

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.24916820
2MARK13.50819765
3MAP3K93.44576702
4EPHA43.30284762
5MAP3K43.01392662
6MAP2K72.52926790
7MINK12.42499559
8DAPK22.26972441
9MAP3K122.26697670
10NTRK12.16156878
11NTRK22.14474257
12CASK2.08866410
13PAK61.98224163
14PRKD31.92324648
15KSR21.92185856
16MAP2K41.87554956
17TAOK31.77403566
18MAP3K21.77325796
19CAMKK11.67897943
20UHMK11.65589192
21CDK191.64476525
22CDK51.59430389
23CAMKK21.58531068
24TNIK1.40377438
25PNCK1.38673718
26RIPK41.35385397
27MAPK131.35063917
28OXSR11.27285289
29DAPK11.25370209
30INSRR1.21489647
31PRKCH1.19355250
32PLK21.19064162
33FES1.18089564
34GRK51.16718961
35ARAF1.16363041
36KSR11.15350954
37MAP3K131.14366800
38SGK4941.13237382
39SGK2231.13237382
40PRKCG1.09515494
41CSNK1G21.02851531
42PHKG11.02737432
43PHKG21.02737432
44PAK31.01317820
45CAMK2A1.01230762
46SIK20.99776097
47PRPF4B0.99535792
48TXK0.99340204
49CAMK2B0.99102950
50RET0.97296206
51MAP3K10.92535516
52SYK0.91033485
53TYRO30.89751054
54STK110.89132180
55MARK20.86766434
56CDK140.84571959
57SCYL20.84233776
58ERBB30.84199952
59TRIM280.83843762
60CDK180.82541791
61CDK150.81742009
62MAPKAPK50.79533174
63MAPK120.77751663
64STK380.77534233
65SGK20.77359579
66WNK10.76710976
67STK390.75257403
68PRKCE0.73497716
69TEC0.72392216
70ITK0.70186838
71CDK11A0.69472230
72TAOK10.69108817
73CAMK10.68946666
74JAK10.68625945
75CAMK2D0.68515247
76WNK30.68162497
77SGK10.67800328
78HIPK20.67735633
79SGK30.66577748
80CAMK40.66096528
81WNK40.65128604
82CAMK1G0.65052401
83PDPK10.64969090
84PDK10.63900211
85ALK0.61431680
86CDC42BPA0.60778921
87FGFR20.60535970
88DYRK1A0.59042216
89PRKG20.56727562
90CCNB10.54769701
91TNK20.54430897
92CSNK1G30.54415661
93PKN10.54334313
94FYN0.52924368
95CAMK2G0.52746943
96BMPR20.51635107
97NEK60.50992024
98BCR0.49729208
99RPS6KA30.49172144
100RAF10.47401063
101RPS6KA20.45178648
102AKT30.44447198
103MAPK100.43964431
104PRKCQ0.43789096
105PRKCZ0.43660713
106MAP3K60.42194537
107SIK30.42169751
108PINK10.41623696
109LATS20.40035684
110FRK0.39729149
111MAP4K10.38351768
112CSNK1A1L0.38027927
113FER0.37750200
114MAP2K60.36907378
115JAK20.35948905
116MAPK70.35812414
117MAPK150.35740415
118PRKCB0.35678865

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.35011292
2Synaptic vesicle cycle_Homo sapiens_hsa047213.33552803
3* GABAergic synapse_Homo sapiens_hsa047272.75506848
4* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.52780911
5* Circadian entrainment_Homo sapiens_hsa047132.52509597
6* Morphine addiction_Homo sapiens_hsa050322.48926752
7* Olfactory transduction_Homo sapiens_hsa047402.40520361
8* Long-term potentiation_Homo sapiens_hsa047202.37082336
9* Amphetamine addiction_Homo sapiens_hsa050312.35811866
10* Insulin secretion_Homo sapiens_hsa049112.34438598
11* Glutamatergic synapse_Homo sapiens_hsa047242.31951964
12* Dopaminergic synapse_Homo sapiens_hsa047282.20199413
13* Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.97230226
14* Cocaine addiction_Homo sapiens_hsa050301.91186461
15* Cholinergic synapse_Homo sapiens_hsa047251.89860570
16Collecting duct acid secretion_Homo sapiens_hsa049661.85932423
17* Salivary secretion_Homo sapiens_hsa049701.84017845
18* Serotonergic synapse_Homo sapiens_hsa047261.73838075
19Long-term depression_Homo sapiens_hsa047301.70692212
20* Taste transduction_Homo sapiens_hsa047421.70101455
21* Renin secretion_Homo sapiens_hsa049241.69447865
22* Aldosterone synthesis and secretion_Homo sapiens_hsa049251.67265829
23* Gastric acid secretion_Homo sapiens_hsa049711.66424450
24* Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.61969378
25* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.51908161
26Type II diabetes mellitus_Homo sapiens_hsa049301.50670026
27* Oxytocin signaling pathway_Homo sapiens_hsa049211.46520852
28* Calcium signaling pathway_Homo sapiens_hsa040201.33265493
29* Vibrio cholerae infection_Homo sapiens_hsa051101.29524803
30* Gap junction_Homo sapiens_hsa045401.22664579
31* GnRH signaling pathway_Homo sapiens_hsa049121.19974761
32* cAMP signaling pathway_Homo sapiens_hsa040241.18769330
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16542217
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14427239
35* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13891895
36* Estrogen signaling pathway_Homo sapiens_hsa049151.12999656
37cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08036330
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06792319
39* Platelet activation_Homo sapiens_hsa046111.04927788
40Type I diabetes mellitus_Homo sapiens_hsa049401.02134446
41Pancreatic secretion_Homo sapiens_hsa049721.00646841
42Axon guidance_Homo sapiens_hsa043601.00470292
43ErbB signaling pathway_Homo sapiens_hsa040120.98376816
44Glioma_Homo sapiens_hsa052140.98339761
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96254477
46* Vascular smooth muscle contraction_Homo sapiens_hsa042700.94475647
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92349364
48Dorso-ventral axis formation_Homo sapiens_hsa043200.92046068
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.91528183
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90991943
51Nitrogen metabolism_Homo sapiens_hsa009100.88069383
52* Melanogenesis_Homo sapiens_hsa049160.86346389
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83719184
54Cardiac muscle contraction_Homo sapiens_hsa042600.80698160
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76731634
56* Thyroid hormone synthesis_Homo sapiens_hsa049180.76494438
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.76084003
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74886364
59T cell receptor signaling pathway_Homo sapiens_hsa046600.73394930
60Fatty acid biosynthesis_Homo sapiens_hsa000610.72560770
61Phototransduction_Homo sapiens_hsa047440.69686688
62* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69032665
63* MAPK signaling pathway_Homo sapiens_hsa040100.66944969
64Alcoholism_Homo sapiens_hsa050340.65443781
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.63296853
66Renal cell carcinoma_Homo sapiens_hsa052110.62580503
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.61148591
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59563681
69Regulation of autophagy_Homo sapiens_hsa041400.58845930
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58761859
71Choline metabolism in cancer_Homo sapiens_hsa052310.58704194
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58635302
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57741969
74Inositol phosphate metabolism_Homo sapiens_hsa005620.56810067
75* Ras signaling pathway_Homo sapiens_hsa040140.56790332
76Ether lipid metabolism_Homo sapiens_hsa005650.56663164
77* Glucagon signaling pathway_Homo sapiens_hsa049220.55806262
78* Dilated cardiomyopathy_Homo sapiens_hsa054140.55528103
79Alzheimers disease_Homo sapiens_hsa050100.55271827
80* Oocyte meiosis_Homo sapiens_hsa041140.55004978
81Endocytosis_Homo sapiens_hsa041440.54459700
82B cell receptor signaling pathway_Homo sapiens_hsa046620.54278619
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50581924
84Circadian rhythm_Homo sapiens_hsa047100.50438015
85Mineral absorption_Homo sapiens_hsa049780.48380627
86VEGF signaling pathway_Homo sapiens_hsa043700.46560463
87Rap1 signaling pathway_Homo sapiens_hsa040150.45838842
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45542810
89Butanoate metabolism_Homo sapiens_hsa006500.43978713
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43816826
91* Bile secretion_Homo sapiens_hsa049760.43716125
92Endometrial cancer_Homo sapiens_hsa052130.43636665
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43497418
94mTOR signaling pathway_Homo sapiens_hsa041500.43429232
95Oxidative phosphorylation_Homo sapiens_hsa001900.39927388
96Non-small cell lung cancer_Homo sapiens_hsa052230.38981866
97Rheumatoid arthritis_Homo sapiens_hsa053230.38180013
98* Chemokine signaling pathway_Homo sapiens_hsa040620.37797323
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36896475
100Prolactin signaling pathway_Homo sapiens_hsa049170.36796731
101* Insulin signaling pathway_Homo sapiens_hsa049100.36370591
102* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35956386
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.35033510
104Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34102219
105Lysosome_Homo sapiens_hsa041420.32526755
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30588498
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29918007
108Phagosome_Homo sapiens_hsa041450.28841866
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27957829
110* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27182914
111* Prion diseases_Homo sapiens_hsa050200.26305163
112* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26135987
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23296352
114African trypanosomiasis_Homo sapiens_hsa051430.21568665
115alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20278174
116AMPK signaling pathway_Homo sapiens_hsa041520.19475883

Most similar genes based on co-expression Upload to Enrichr

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