PRKAG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1NADH metabolic process (GO:0006734)6.38808361
2tricarboxylic acid cycle (GO:0006099)5.76491269
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.30096052
4oxaloacetate metabolic process (GO:0006107)5.13826793
5ATP synthesis coupled proton transport (GO:0015986)4.70141648
6energy coupled proton transport, down electrochemical gradient (GO:0015985)4.70141648
7oxidative phosphorylation (GO:0006119)4.61668234
8positive regulation of mitochondrial fission (GO:0090141)4.01545437
9succinate metabolic process (GO:0006105)3.91520656
10protein deneddylation (GO:0000338)3.90223943
11L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.73627747
12heme biosynthetic process (GO:0006783)3.63406401
13ribosome assembly (GO:0042255)3.58684243
14cullin deneddylation (GO:0010388)3.57943475
15purine nucleotide salvage (GO:0032261)3.53744290
16cellular ketone body metabolic process (GO:0046950)3.49292951
17formation of translation preinitiation complex (GO:0001731)3.48069295
18positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.46819750
19pentose-phosphate shunt (GO:0006098)3.46505149
20ribosomal large subunit biogenesis (GO:0042273)3.46453558
21short-chain fatty acid metabolic process (GO:0046459)3.41532232
22lysine metabolic process (GO:0006553)3.39882535
23lysine catabolic process (GO:0006554)3.39882535
24COPI coating of Golgi vesicle (GO:0048205)3.38694451
25Golgi transport vesicle coating (GO:0048200)3.38694451
26respiratory electron transport chain (GO:0022904)3.38206019
27ribosomal small subunit assembly (GO:0000028)3.37759427
28proteasome assembly (GO:0043248)3.37700537
29L-methionine salvage (GO:0071267)3.35815809
30L-methionine biosynthetic process (GO:0071265)3.35815809
31amino acid salvage (GO:0043102)3.35815809
32nucleobase biosynthetic process (GO:0046112)3.34528776
33regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.33876031
34DNA deamination (GO:0045006)3.33554915
35valine metabolic process (GO:0006573)3.31473557
36electron transport chain (GO:0022900)3.29246221
372-oxoglutarate metabolic process (GO:0006103)3.28524990
38protoporphyrinogen IX metabolic process (GO:0046501)3.28015641
39protoporphyrinogen IX biosynthetic process (GO:0006782)3.27440899
40purine nucleobase biosynthetic process (GO:0009113)3.26628718
41sarcomere organization (GO:0045214)3.25800940
42porphyrin-containing compound biosynthetic process (GO:0006779)3.23483510
43ribosome biogenesis (GO:0042254)3.22743883
44regulation of mitochondrial translation (GO:0070129)3.22408111
45negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.16558476
46tricarboxylic acid metabolic process (GO:0072350)3.16475260
47ribonucleoprotein complex biogenesis (GO:0022613)3.14782572
48negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.13603815
49tRNA aminoacylation for protein translation (GO:0006418)3.09382817
50rRNA modification (GO:0000154)3.07289316
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.06448248
52NADPH regeneration (GO:0006740)3.05610950
53amino acid activation (GO:0043038)3.05103391
54tRNA aminoacylation (GO:0043039)3.05103391
55regulation of translational fidelity (GO:0006450)3.04993894
56protein maturation by protein folding (GO:0022417)3.04953826
57regulation of acyl-CoA biosynthetic process (GO:0050812)3.04848940
58purine-containing compound salvage (GO:0043101)3.04118108
59muscle filament sliding (GO:0030049)3.02438669
60actin-myosin filament sliding (GO:0033275)3.02438669
61nucleotide transmembrane transport (GO:1901679)3.02159927
62positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.99782949
63ketone body metabolic process (GO:1902224)2.99572857
64antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.98895301
65antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.98895301
66ribosomal small subunit biogenesis (GO:0042274)2.97552370
67termination of RNA polymerase III transcription (GO:0006386)2.97038264
68transcription elongation from RNA polymerase III promoter (GO:0006385)2.97038264
69ubiquinone metabolic process (GO:0006743)2.96895456
70peptidyl-histidine modification (GO:0018202)2.96780037
71galactose catabolic process (GO:0019388)2.96567756
72regulation of coenzyme metabolic process (GO:0051196)2.96552052
73regulation of cofactor metabolic process (GO:0051193)2.96552052
74regulation of cellular amino acid metabolic process (GO:0006521)2.96181938
75tetrapyrrole biosynthetic process (GO:0033014)2.95197863
76cellular component biogenesis (GO:0044085)2.94762718
77purine nucleoside monophosphate biosynthetic process (GO:0009127)2.94184298
78purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.94184298
79mitochondrial fusion (GO:0008053)2.93556771
80DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.93271185
81inner mitochondrial membrane organization (GO:0007007)2.93177620
82metallo-sulfur cluster assembly (GO:0031163)2.92861021
83iron-sulfur cluster assembly (GO:0016226)2.92861021
84intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.91613495
85signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.91613495
86ATP biosynthetic process (GO:0006754)2.91398914
87protein targeting to ER (GO:0045047)2.91187721
88regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.90991268
89SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.90734984
90signal transduction involved in DNA integrity checkpoint (GO:0072401)2.90185469
91signal transduction involved in DNA damage checkpoint (GO:0072422)2.90185469
92signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.88995352
93signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.88995352
94signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.88995352
95AMP metabolic process (GO:0046033)2.88370378
96heme metabolic process (GO:0042168)2.86613442
97mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.86603598
98cotranslational protein targeting to membrane (GO:0006613)2.86412288
99anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.86381795
100negative regulation of ligase activity (GO:0051352)2.85418218
101negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.85418218
102antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.84875758
103protein targeting to mitochondrion (GO:0006626)2.84628924
104protein localization to endoplasmic reticulum (GO:0070972)2.84427879
105heart contraction (GO:0060047)2.84403417
106heart process (GO:0003015)2.84403417
107signal transduction involved in cell cycle checkpoint (GO:0072395)2.83990373
108establishment of protein localization to endoplasmic reticulum (GO:0072599)2.83376241
109viral transcription (GO:0019083)2.83134064
110sphingosine metabolic process (GO:0006670)2.82923823
111GMP metabolic process (GO:0046037)2.82775878
112translation (GO:0006412)2.82304728
113mitochondrial respiratory chain complex I assembly (GO:0032981)2.82189394
114NADH dehydrogenase complex assembly (GO:0010257)2.82189394
115mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.82189394
116regulation of mitochondrial fission (GO:0090140)2.80455785
117maturation of SSU-rRNA (GO:0030490)2.80433496
118protein-cofactor linkage (GO:0018065)2.80241696
119retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.78945232
120telomere maintenance via semi-conservative replication (GO:0032201)2.78273324
121IMP biosynthetic process (GO:0006188)2.78033593
122cellular metabolic compound salvage (GO:0043094)2.77879449
123aerobic respiration (GO:0009060)2.77354679
124chaperone mediated protein folding requiring cofactor (GO:0051085)2.76081969
125DNA strand elongation involved in DNA replication (GO:0006271)2.75185222
126mannosylation (GO:0097502)2.74954187
127base-excision repair, AP site formation (GO:0006285)2.74426713
128translational termination (GO:0006415)2.72746526
129branched-chain amino acid catabolic process (GO:0009083)2.71554099
130establishment of protein localization to mitochondrion (GO:0072655)2.70723623
131nucleoside salvage (GO:0043174)2.69931279
132protein neddylation (GO:0045116)2.69299640
133proline biosynthetic process (GO:0006561)2.68671100
134DNA replication initiation (GO:0006270)2.67971452
135translational initiation (GO:0006413)2.67876461
136glucose catabolic process (GO:0006007)2.67870166
137ribonucleoside monophosphate biosynthetic process (GO:0009156)2.67641156
138pteridine-containing compound biosynthetic process (GO:0042559)2.67563328
139ubiquinone biosynthetic process (GO:0006744)2.67489260
140quinone biosynthetic process (GO:1901663)2.67489260
141nucleoside monophosphate biosynthetic process (GO:0009124)2.66728977
142homocysteine metabolic process (GO:0050667)2.66660918
143misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.66464668
144aspartate family amino acid biosynthetic process (GO:0009067)2.66150696
145GDP-mannose metabolic process (GO:0019673)2.66011559
146DNA strand elongation (GO:0022616)2.65751451
147negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.64397076
148rRNA methylation (GO:0031167)2.63740499
149biotin metabolic process (GO:0006768)2.62898107
150quinone metabolic process (GO:1901661)2.62357638
151branched-chain amino acid metabolic process (GO:0009081)2.61834415
152deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.61462633
153protein localization to mitochondrion (GO:0070585)2.60523948
154viral protein processing (GO:0019082)2.60106776
155glycogen catabolic process (GO:0005980)2.59839412
156protein complex biogenesis (GO:0070271)2.58524171
157dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.58370920
158translational elongation (GO:0006414)2.58203304
159pseudouridine synthesis (GO:0001522)2.57857062
160lipid particle organization (GO:0034389)2.55859593
161galactose metabolic process (GO:0006012)2.55357954
162sphingoid metabolic process (GO:0046519)2.54868553
163diol metabolic process (GO:0034311)2.54580111

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.72140335
2E2F7_22180533_ChIP-Seq_HELA_Human4.50019619
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.11720677
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.06467421
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.02336191
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.97856263
7* GABP_17652178_ChIP-ChIP_JURKAT_Human2.77736814
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.72876159
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.71098248
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.67126208
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.60657579
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.56585693
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.35899273
14ZNF263_19887448_ChIP-Seq_K562_Human2.30568148
15SRF_21415370_ChIP-Seq_HL-1_Mouse2.09027118
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.03255276
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.02797280
18* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.00934241
19* VDR_23849224_ChIP-Seq_CD4+_Human2.00390505
20NELFA_20434984_ChIP-Seq_ESCs_Mouse1.92050386
21ELF1_17652178_ChIP-ChIP_JURKAT_Human1.91439058
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.89164943
23E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88413359
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.87698544
25MYC_19030024_ChIP-ChIP_MESCs_Mouse1.86293810
26TP63_17297297_ChIP-ChIP_HaCaT_Human1.85794943
27THAP11_20581084_ChIP-Seq_MESCs_Mouse1.83752978
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82369904
29* GABP_19822575_ChIP-Seq_HepG2_Human1.82239529
30TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.81385027
31DCP1A_22483619_ChIP-Seq_HELA_Human1.80149201
32XRN2_22483619_ChIP-Seq_HELA_Human1.76794577
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.71080926
34MYC_22102868_ChIP-Seq_BL_Human1.70565360
35FOXP3_21729870_ChIP-Seq_TREG_Human1.70510619
36CIITA_25753668_ChIP-Seq_RAJI_Human1.70468096
37* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.68442471
38* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.67975693
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67622537
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.59946651
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.59570026
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.57656328
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.57447773
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57157834
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.56640622
46AR_21909140_ChIP-Seq_LNCAP_Human1.55643717
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.53852238
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.51829659
49ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.51127040
50HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.49126702
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48583505
52* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46401214
53PPARA_22158963_ChIP-Seq_LIVER_Mouse1.43662338
54GATA1_22025678_ChIP-Seq_K562_Human1.42646045
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42480589
56BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.42216372
57* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41634638
58VDR_21846776_ChIP-Seq_THP-1_Human1.40158816
59CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.39343121
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39288497
61* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.38576035
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.38522415
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35339814
64ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34129336
65* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32413854
66CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.31310961
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29953111
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.29097179
69* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.25465680
70* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24541359
71HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.23985192
72TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22280562
73KDM5A_27292631_Chip-Seq_BREAST_Human1.19370272
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19346061
75HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17586350
76RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17107535
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16622224
78CLOCK_20551151_ChIP-Seq_293T_Human1.15772414
79TET1_21451524_ChIP-Seq_MESCs_Mouse1.15414924
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15354234
81ELF5_23300383_ChIP-Seq_T47D_Human1.15202596
82CTCF_18555785_ChIP-Seq_MESCs_Mouse1.15185979
83YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14707735
84ELK1_19687146_ChIP-ChIP_HELA_Human1.13227108
85CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12473337
86* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12017314
87SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11658325
88* SPI1_23547873_ChIP-Seq_NB4_Human1.10151127
89RXR_22158963_ChIP-Seq_LIVER_Mouse1.09619419
90STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09360087
91ATF3_27146783_Chip-Seq_COLON_Human1.08683336
92TBX5_21415370_ChIP-Seq_HL-1_Mouse1.08250791
93* TTF2_22483619_ChIP-Seq_HELA_Human1.07962864
94PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.07805948
95ELF1_20517297_ChIP-Seq_JURKAT_Human1.06920704
96ELK1_22589737_ChIP-Seq_MCF10A_Human1.06910575
97MYCN_18555785_ChIP-Seq_MESCs_Mouse1.06583928
98MAF_26560356_Chip-Seq_TH1_Human1.04411673
99* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.03308385
100SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03136642
101SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01914180
102* FOXP1_21924763_ChIP-Seq_HESCs_Human1.01912826
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01577621
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00830177
105* TFEB_21752829_ChIP-Seq_HELA_Human1.00555291
106* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00274040
107E2F1_21310950_ChIP-Seq_MCF-7_Human1.00185226
108EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99074359
109MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.98091282
110EGR1_19374776_ChIP-ChIP_THP-1_Human0.97382377
111UTX_26944678_Chip-Seq_JUKART_Human0.97098164
112SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.96756676
113STAT4_19710469_ChIP-ChIP_TH1__Mouse0.96709115
114MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96394743
115BCL6_27268052_Chip-Seq_Bcells_Human0.96020561
116ELK3_25401928_ChIP-Seq_HUVEC_Human0.95183883
117TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94932977
118* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93788518
119ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.93062027
120IRF8_22096565_ChIP-ChIP_GC-B_Human0.92852335
121DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91723794
122MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.91485591
123SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91227280
124NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.88737580
125RACK7_27058665_Chip-Seq_MCF-7_Human0.87592980
126P68_20966046_ChIP-Seq_HELA_Human0.87517455
127CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87273078
128CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.87161947

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.52960683
2MP0003656_abnormal_erythrocyte_physiolo3.35166578
3MP0002837_dystrophic_cardiac_calcinosis3.20300110
4MP0003646_muscle_fatigue3.19851075
5MP0004084_abnormal_cardiac_muscle3.10007080
6MP0006036_abnormal_mitochondrial_physio2.90408700
7MP0004147_increased_porphyrin_level2.58516661
8MP0005171_absent_coat_pigmentation2.57833906
9MP0004145_abnormal_muscle_electrophysio2.57397052
10MP0000372_irregular_coat_pigmentation2.40927622
11MP0002876_abnormal_thyroid_physiology2.31030894
12MP0006054_spinal_hemorrhage2.27492154
13MP0003693_abnormal_embryo_hatching2.26367587
14MP0004215_abnormal_myocardial_fiber2.22980165
15MP0000749_muscle_degeneration2.18266338
16MP0004036_abnormal_muscle_relaxation2.14504554
17MP0002396_abnormal_hematopoietic_system2.12695437
18MP0005451_abnormal_body_composition2.10091646
19MP0005503_abnormal_tendon_morphology2.03042331
20MP0004957_abnormal_blastocyst_morpholog1.99773467
21MP0005330_cardiomyopathy1.99453569
22MP0000751_myopathy1.98291678
23MP0003950_abnormal_plasma_membrane1.86565444
24MP0006035_abnormal_mitochondrial_morpho1.84099919
25MP0001873_stomach_inflammation1.78750267
26MP0001661_extended_life_span1.73509540
27MP0002132_abnormal_respiratory_system1.67057820
28MP0003786_premature_aging1.66347272
29MP0003186_abnormal_redox_activity1.60457134
30MP0000490_abnormal_crypts_of1.56233726
31MP0002269_muscular_atrophy1.56058000
32MP0009333_abnormal_splenocyte_physiolog1.53947638
33MP0001346_abnormal_lacrimal_gland1.53462661
34MP0005408_hypopigmentation1.52232068
35MP0008260_abnormal_autophagy1.51713079
36MP0003763_abnormal_thymus_physiology1.48656629
37MP0003221_abnormal_cardiomyocyte_apopto1.48457317
38MP0003111_abnormal_nucleus_morphology1.45478501
39MP0001544_abnormal_cardiovascular_syste1.45412869
40MP0005385_cardiovascular_system_phenoty1.45412869
41MP0008775_abnormal_heart_ventricle1.43563508
42MP0003191_abnormal_cellular_cholesterol1.43386418
43MP0009840_abnormal_foam_cell1.42017067
44MP0010030_abnormal_orbit_morphology1.40989802
45MP0001542_abnormal_bone_strength1.39886220
46MP0002295_abnormal_pulmonary_circulatio1.38079651
47MP0000750_abnormal_muscle_regeneration1.37026742
48MP0008058_abnormal_DNA_repair1.36393906
49MP0005397_hematopoietic_system_phenotyp1.34137528
50MP0001545_abnormal_hematopoietic_system1.34137528
51MP0004484_altered_response_of1.34107399
52MP0003136_yellow_coat_color1.33040615
53MP0000358_abnormal_cell_content/1.32566915
54MP0005501_abnormal_skin_physiology1.31721498
55MP0002972_abnormal_cardiac_muscle1.30690194
56MP0003567_abnormal_fetal_cardiomyocyte1.30344785
57MP0003077_abnormal_cell_cycle1.28563870
58MP0001243_abnormal_dermal_layer1.28105561
59MP0001764_abnormal_homeostasis1.27113715
60MP0000013_abnormal_adipose_tissue1.26811644
61MP0006138_congestive_heart_failure1.26461451
62MP0004087_abnormal_muscle_fiber1.24794613
63MP0003566_abnormal_cell_adhesion1.24573170
64MP0005365_abnormal_bile_salt1.23439161
65MP0005257_abnormal_intraocular_pressure1.23123351
66MP0002139_abnormal_hepatobiliary_system1.19052955
67MP0005636_abnormal_mineral_homeostasis1.18384235
68MP0009643_abnormal_urine_homeostasis1.15452856
69MP0002106_abnormal_muscle_physiology1.15136539
70MP0002722_abnormal_immune_system1.14312250
71MP0002398_abnormal_bone_marrow1.13261772
72MP0005319_abnormal_enzyme/_coenzyme1.12989180
73MP0004808_abnormal_hematopoietic_stem1.12350833
74MP0000689_abnormal_spleen_morphology1.11508780
75MP0004134_abnormal_chest_morphology1.11263354
76MP0003959_abnormal_lean_body1.10947198
77MP0005671_abnormal_response_to1.10469800
78MP0008438_abnormal_cutaneous_collagen1.10388714
79MP0008875_abnormal_xenobiotic_pharmacok1.09828642
80MP0002166_altered_tumor_susceptibility1.07165557
81MP0001958_emphysema1.06318731
82MP0000003_abnormal_adipose_tissue1.05655125
83MP0004130_abnormal_muscle_cell1.05654089
84MP0010630_abnormal_cardiac_muscle1.04284521
85MP0009697_abnormal_copulation1.03960018
86MP0010094_abnormal_chromosome_stability1.03389226
87MP0005360_urolithiasis1.03188277
88MP0005332_abnormal_amino_acid1.03141185
89MP0002060_abnormal_skin_morphology1.02753822
90MP0005266_abnormal_metabolism1.01656655
91MP0010329_abnormal_lipoprotein_level1.01100230
92MP0005620_abnormal_muscle_contractility1.01045581
93MP0000613_abnormal_salivary_gland1.00938066
94MP0005085_abnormal_gallbladder_physiolo1.00133696
95MP0000747_muscle_weakness1.00078944
96MP0010155_abnormal_intestine_physiology0.99388252
97MP0003315_abnormal_perineum_morphology0.99108869
98MP0000685_abnormal_immune_system0.98095067
99MP0005670_abnormal_white_adipose0.97835175
100MP0002019_abnormal_tumor_incidence0.96420108
101MP0000609_abnormal_liver_physiology0.95827175
102MP0000343_altered_response_to0.94373323
103MP0002877_abnormal_melanocyte_morpholog0.94229844
104MP0005584_abnormal_enzyme/coenzyme_acti0.93752149
105MP0005369_muscle_phenotype0.93712482
106MP0002429_abnormal_blood_cell0.93505580
107MP0003011_delayed_dark_adaptation0.93448331
108MP0009250_abnormal_appendicular_skeleto0.93032268
109MP0005083_abnormal_biliary_tract0.92881536
110MP0005275_abnormal_skin_tensile0.92051174
111MP0000703_abnormal_thymus_morphology0.91390261
112MP0002095_abnormal_skin_pigmentation0.90376483
113MP0001730_embryonic_growth_arrest0.90008112
114MP0000759_abnormal_skeletal_muscle0.89917617
115MP0005187_abnormal_penis_morphology0.88398328
116MP0005464_abnormal_platelet_physiology0.87844120
117MP0005165_increased_susceptibility_to0.87189078
118MP0000858_altered_metastatic_potential0.86963308
119MP0003705_abnormal_hypodermis_morpholog0.86354371
120MP0000465_gastrointestinal_hemorrhage0.85555768
121MP0008932_abnormal_embryonic_tissue0.85455030
122MP0003123_paternal_imprinting0.85356880
123MP0005023_abnormal_wound_healing0.85103490
124MP0009785_altered_susceptibility_to0.84661599
125MP0004043_abnormal_pH_regulation0.83976017
126MP0005075_abnormal_melanosome_morpholog0.83135793
127MP0003279_aneurysm0.82889469
128MP0008007_abnormal_cellular_replicative0.81845281
129MP0005058_abnormal_lysosome_morphology0.81517137
130MP0010771_integument_phenotype0.81371562
131MP0005410_abnormal_fertilization0.80638791
132MP0004858_abnormal_nervous_system0.80583010
133MP0003866_abnormal_defecation0.79197407
134MP0008469_abnormal_protein_level0.78886654
135MP0002108_abnormal_muscle_morphology0.78523227
136MP0004233_abnormal_muscle_weight0.77285287
137MP0001756_abnormal_urination0.77129780
138MP0000762_abnormal_tongue_morphology0.77091624
139MP0001845_abnormal_inflammatory_respons0.76467091
140MP0000716_abnormal_immune_system0.75981243
141MP0002971_abnormal_brown_adipose0.75721139
142MP0005376_homeostasis/metabolism_phenot0.74828891
143MP0001186_pigmentation_phenotype0.74083497
144MP0002332_abnormal_exercise_endurance0.73988799
145MP0000681_abnormal_thyroid_gland0.73579827
146MP0000427_abnormal_hair_cycle0.72576634
147MP0009384_cardiac_valve_regurgitation0.71833666
148MP0000371_diluted_coat_color0.70065641
149MP0002098_abnormal_vibrissa_morphology0.67004018
150MP0001881_abnormal_mammary_gland0.66448352

Predicted human phenotypes

RankGene SetZ-score
1Hepatic necrosis (HP:0002605)4.08430711
2Abnormal mitochondria in muscle tissue (HP:0008316)3.99004656
3Acute necrotizing encephalopathy (HP:0006965)3.88181301
4Pustule (HP:0200039)3.76885633
5Hepatocellular necrosis (HP:0001404)3.76041328
6Vertebral compression fractures (HP:0002953)3.72435391
7Muscle fiber inclusion bodies (HP:0100299)3.59901041
8Nemaline bodies (HP:0003798)3.57358660
9Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.50385611
10Acute encephalopathy (HP:0006846)3.48320367
11Abnormality of fatty-acid metabolism (HP:0004359)3.44158998
12Mitochondrial inheritance (HP:0001427)3.43407428
13Increased CSF lactate (HP:0002490)3.40600947
14Rhabdomyolysis (HP:0003201)3.38049604
15Abnormality of the heme biosynthetic pathway (HP:0010472)3.36745433
16Dicarboxylic aciduria (HP:0003215)3.27658993
17Abnormality of dicarboxylic acid metabolism (HP:0010995)3.27658993
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.21309160
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.21309160
20Abnormality of alanine metabolism (HP:0010916)3.20037760
21Hyperalaninemia (HP:0003348)3.20037760
22Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.20037760
23Increased serum pyruvate (HP:0003542)3.17379442
24Abnormality of glycolysis (HP:0004366)3.17379442
25Palpitations (HP:0001962)3.14218302
26Myoglobinuria (HP:0002913)3.13763000
27Type 1 muscle fiber predominance (HP:0003803)3.08391598
28Petechiae (HP:0000967)3.08390099
29Exercise-induced muscle cramps (HP:0003710)3.07091348
30Progressive macrocephaly (HP:0004481)2.96303279
31Microretrognathia (HP:0000308)2.95410750
32Lactic acidosis (HP:0003128)2.95221419
33Testicular atrophy (HP:0000029)2.94801892
34Myopathic facies (HP:0002058)2.94314736
35Cerebral edema (HP:0002181)2.90885411
36Increased serum lactate (HP:0002151)2.83323987
37Conjunctival hamartoma (HP:0100780)2.79220964
38Respiratory failure (HP:0002878)2.76671139
39Increased hepatocellular lipid droplets (HP:0006565)2.69892661
40Generalized aminoaciduria (HP:0002909)2.69167825
41Type I transferrin isoform profile (HP:0003642)2.68526595
42Ventricular tachycardia (HP:0004756)2.67589571
43Multiple enchondromatosis (HP:0005701)2.65629923
44Increased muscle lipid content (HP:0009058)2.64608200
45Ragged-red muscle fibers (HP:0003200)2.63639456
46Exercise intolerance (HP:0003546)2.61937899
47Nonimmune hydrops fetalis (HP:0001790)2.61654682
48Neoplasm of the adrenal gland (HP:0100631)2.61446411
49Hypokinesia (HP:0002375)2.58224105
50Abnormality of glycolipid metabolism (HP:0010969)2.54653539
51Abnormality of liposaccharide metabolism (HP:0010968)2.54653539
52Abnormality of glycosphingolipid metabolism (HP:0004343)2.54653539
53Neuroendocrine neoplasm (HP:0100634)2.54147948
54Hypoglycemic coma (HP:0001325)2.51730049
55Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.50590367
56Methylmalonic aciduria (HP:0012120)2.46247245
57Neoplasm of head and neck (HP:0012288)2.45124766
58Esophageal neoplasm (HP:0100751)2.45124766
59Lethargy (HP:0001254)2.44399335
60Renal Fanconi syndrome (HP:0001994)2.43098858
61Exercise-induced myalgia (HP:0003738)2.35947614
62Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.35629771
63Abnormal protein N-linked glycosylation (HP:0012347)2.35629771
64Abnormal protein glycosylation (HP:0012346)2.35629771
65Abnormal glycosylation (HP:0012345)2.35629771
66Cholelithiasis (HP:0001081)2.35394693
67Pheochromocytoma (HP:0002666)2.35074499
68Neck muscle weakness (HP:0000467)2.33986476
69Increased intramyocellular lipid droplets (HP:0012240)2.33497129
70Nausea (HP:0002018)2.33462480
71CNS demyelination (HP:0007305)2.33189353
72IgM deficiency (HP:0002850)2.29626748
73Ulnar deviation of the wrist (HP:0003049)2.29545179
74Sudden death (HP:0001699)2.28219199
75Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.23682185
76Hyperammonemia (HP:0001987)2.21409239
77Lipoatrophy (HP:0100578)2.20923100
78Abnormal number of erythroid precursors (HP:0012131)2.19682269
79Gout (HP:0001997)2.19342912
80Hyperbilirubinemia (HP:0002904)2.18201892
81Ketoacidosis (HP:0001993)2.17346174
82Emotional lability (HP:0000712)2.16234118
83Mitral stenosis (HP:0001718)2.15596822
84Reticulocytosis (HP:0001923)2.13365122
85EMG: myopathic abnormalities (HP:0003458)2.13152148
86Abnormal gallbladder morphology (HP:0012437)2.12692822
87Spastic paraparesis (HP:0002313)2.12255674
88Cholecystitis (HP:0001082)2.08976270
89Abnormal gallbladder physiology (HP:0012438)2.08976270
90Opisthotonus (HP:0002179)2.08911458
91Ketosis (HP:0001946)2.08142682
92Type II lissencephaly (HP:0007260)2.07947830
93Abnormality of the calf musculature (HP:0001430)2.07875094
94Achilles tendon contracture (HP:0001771)2.07532168
95Distal lower limb muscle weakness (HP:0009053)2.01351045
96Abnormal hemoglobin (HP:0011902)2.00610642
97Vacuolated lymphocytes (HP:0001922)2.00174266
98Progressive muscle weakness (HP:0003323)1.98474425
99Lipid accumulation in hepatocytes (HP:0006561)1.98425814
100Dilated cardiomyopathy (HP:0001644)1.98380136
101Round ear (HP:0100830)1.97408173
102Abnormality of cells of the erythroid lineage (HP:0012130)1.96783602
103Polycythemia (HP:0001901)1.95203741
104Abnormality of the intrinsic pathway (HP:0010989)1.94495920
1053-Methylglutaconic aciduria (HP:0003535)1.91808454
106Redundant skin (HP:0001582)1.89515397
107Cerebral palsy (HP:0100021)1.88836312
108Birth length less than 3rd percentile (HP:0003561)1.88671732
109Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.86772320
110Myotonia (HP:0002486)1.85888689
111Hand muscle atrophy (HP:0009130)1.85357065
112Metabolic acidosis (HP:0001942)1.83972030
113Delayed gross motor development (HP:0002194)1.83926802
114Increased connective tissue (HP:0009025)1.83581179
115CNS hypomyelination (HP:0003429)1.83453795
116Muscle fiber splitting (HP:0003555)1.83186827
117Vomiting (HP:0002013)1.82747590
118Cerebellar dysplasia (HP:0007033)1.81939155
119Right ventricular cardiomyopathy (HP:0011663)1.80859242
120Deformed tarsal bones (HP:0008119)1.80378074
121Trismus (HP:0000211)1.80122793
122Premature rupture of membranes (HP:0001788)1.80066328
123Muscle stiffness (HP:0003552)1.79841678
124Muscle hypertrophy of the lower extremities (HP:0008968)1.79247426
125Irregular epiphyses (HP:0010582)1.78825099
126Scapular winging (HP:0003691)1.77965836
127Protrusio acetabuli (HP:0003179)1.77802135
128Abnormality of skeletal muscle fiber size (HP:0012084)1.77240891
129Aplastic anemia (HP:0001915)1.76735196
130Poikilocytosis (HP:0004447)1.76468787
131Respiratory difficulties (HP:0002880)1.75880697
132Asymmetric septal hypertrophy (HP:0001670)1.74781043
133Amniotic constriction ring (HP:0009775)1.74583451
134Abnormality of placental membranes (HP:0011409)1.74583451
135Congenital ichthyosiform erythroderma (HP:0007431)1.74565147
136Increased serum ferritin (HP:0003281)1.72604343
137Cerebral hypomyelination (HP:0006808)1.72242440
138Thrombocytosis (HP:0001894)1.69967110
139Microvesicular hepatic steatosis (HP:0001414)1.65711990
140Abnormality of serum amino acid levels (HP:0003112)1.64965041
141Verrucae (HP:0200043)1.64715679
142Papilloma (HP:0012740)1.64715679
143Proximal tubulopathy (HP:0000114)1.64279021
144Abnormality of reticulocytes (HP:0004312)1.64211761
145Abnormal cartilage morphology (HP:0002763)1.61823130
146Abnormal foot bone ossification (HP:0010675)1.61692711
147Reduced antithrombin III activity (HP:0001976)1.61660743
148Atrioventricular block (HP:0001678)1.60463145

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN23.43499414
2NEK13.42178862
3BUB13.32693563
4BCKDK3.01490745
5TIE12.97725239
6STK162.95118827
7TTN2.75627137
8TRIB32.73318666
9NME22.70810269
10MYLK2.51135257
11TSSK62.51075565
12PHKG12.44444604
13PHKG22.44444604
14KDR2.22526560
15MAP4K12.02115740
16PDK31.98757210
17PDK41.98757210
18FLT31.96937821
19PASK1.84400828
20VRK21.77261263
21PBK1.76530570
22EIF2AK11.76151069
23MAP3K121.71746017
24EEF2K1.66078241
25PIK3CA1.62238361
26IRAK31.58871418
27LRRK21.55273923
28MAPKAPK31.51217984
29ZAP701.48753724
30ACVR1B1.47701018
31TESK21.44060472
32ERN11.42122322
33TESK11.41419312
34MAP4K21.39723795
35PIM21.33925693
36WEE11.32509519
37GRK61.31873102
38CCNB11.30640987
39TGFBR21.27504281
40PAK41.27259719
41STK241.25510125
42RAF11.23982568
43ILK1.22167870
44OBSCN1.21906947
45EPHB21.18220100
46ABL21.17604835
47TGFBR11.13757215
48MAP3K111.13019058
49NEK91.12419677
50WNK41.11277294
51CSNK1G31.10614854
52MAP2K71.08263434
53EIF2AK31.08207206
54STK101.06937616
55BRSK21.05512353
56MAP2K31.05121929
57MST1R1.03356222
58MUSK1.02843989
59CSNK1A1L1.02510720
60MOS1.02213321
61PDK21.02059860
62TLK11.00781112
63VRK10.99688715
64BRSK10.98256473
65EPHA20.95610021
66MET0.94339007
67AKT30.94315147
68LMTK20.94013231
69BCR0.92919446
70CDC70.90857473
71RPS6KB20.87694097
72NME10.86412491
73MAP3K30.82407720
74AKT20.78506430
75BRAF0.78030093
76TEC0.77325397
77TXK0.75940106
78BTK0.75810384
79CAMK2G0.73459227
80RPS6KA50.72179651
81TYK20.71749160
82ERBB30.71343568
83STK390.70306848
84DAPK10.70199043
85SRPK10.70193676
86ADRBK20.69106955
87CDK40.69023524
88AURKB0.67147936
89ZAK0.66542199
90NEK20.66507317
91ARAF0.63235942
92CDK80.62293201
93EPHA30.61975516
94PIK3CG0.61838763
95MAPK110.61105065
96MAP3K100.60785535
97LIMK10.60539362
98ICK0.60226518
99ITK0.59596319
100RPS6KL10.59125903
101RPS6KC10.59125903
102PRKG20.58922262
103MAP2K40.57511874
104CSNK1G10.57162750
105MST40.56346547
106CDK190.56113335
107SCYL20.55633283
108CAMK2D0.55605744
109JAK30.54996547
110DAPK30.54752541
111GRK10.53869100
112TBK10.51006868
113TRPM70.50633788
114RPS6KA60.50437140
115TAOK20.50149422
116MAP3K80.49680146
117PRKD20.49233010
118RPS6KA40.47609208
119PINK10.47202870
120ADRBK10.45933090
121CDK70.44845330
122SYK0.44343068
123KSR20.43661763
124CSNK1G20.41568678
125DYRK30.39516921
126NUAK10.39153499
127AURKA0.38469737
128PRKD30.38300406
129CSNK2A10.37934835
130PAK10.37913473
131MAP2K10.36988766
132MAPKAPK50.36901413
133DMPK0.36147082
134CSNK2A20.35812901
135PLK10.35716694
136MAP3K50.35583217
137TNK20.35539921
138PIM10.35126999
139STK40.34543267
140MAPK120.33865421
141FGFR40.32363392
142OXSR10.32281879
143CAMKK10.31282958
144IRAK40.30577281
145TAOK10.30195990
146KSR10.29953985
147PRKCE0.28741275
148TTK0.28626641
149PRKCI0.26045524
150MAPKAPK20.24954601
151KIT0.24533921
152PLK30.24174176

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.47537048
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.83245213
3Proteasome_Homo sapiens_hsa030503.21179642
4Parkinsons disease_Homo sapiens_hsa050122.80180398
5Oxidative phosphorylation_Homo sapiens_hsa001902.74703562
6Carbon metabolism_Homo sapiens_hsa012002.70080824
7DNA replication_Homo sapiens_hsa030302.55080449
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.37037795
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.21045996
10Propanoate metabolism_Homo sapiens_hsa006402.12917600
11Pyruvate metabolism_Homo sapiens_hsa006202.04977124
12Biosynthesis of amino acids_Homo sapiens_hsa012302.00850498
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.88625071
14Pentose phosphate pathway_Homo sapiens_hsa000301.87603089
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83443961
16Fatty acid degradation_Homo sapiens_hsa000711.77424884
17Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.75607298
18* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.73440830
19Vitamin B6 metabolism_Homo sapiens_hsa007501.67698499
20Ribosome_Homo sapiens_hsa030101.66026967
21Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.62710517
22Huntingtons disease_Homo sapiens_hsa050161.59397591
23Pyrimidine metabolism_Homo sapiens_hsa002401.58460097
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.56526951
25Fructose and mannose metabolism_Homo sapiens_hsa000511.56437501
26Alzheimers disease_Homo sapiens_hsa050101.56041400
27Base excision repair_Homo sapiens_hsa034101.52611170
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.49158176
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48524885
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48214286
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.46175511
32Folate biosynthesis_Homo sapiens_hsa007901.41834838
33RNA polymerase_Homo sapiens_hsa030201.38441076
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.29184014
35Nucleotide excision repair_Homo sapiens_hsa034201.27735669
36Mismatch repair_Homo sapiens_hsa034301.27566128
37Fatty acid metabolism_Homo sapiens_hsa012121.24377524
38Cardiac muscle contraction_Homo sapiens_hsa042601.22628275
39Butanoate metabolism_Homo sapiens_hsa006501.22372750
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.18084998
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.13753505
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.07405921
43Sulfur metabolism_Homo sapiens_hsa009201.05221928
44Lysosome_Homo sapiens_hsa041421.03990909
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02825959
46Galactose metabolism_Homo sapiens_hsa000521.01581188
47RNA transport_Homo sapiens_hsa030131.00760320
48Protein export_Homo sapiens_hsa030600.98032889
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95768271
50One carbon pool by folate_Homo sapiens_hsa006700.92721071
51Spliceosome_Homo sapiens_hsa030400.92714507
52Tryptophan metabolism_Homo sapiens_hsa003800.92624633
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90386834
54Cell cycle_Homo sapiens_hsa041100.90244072
55Peroxisome_Homo sapiens_hsa041460.90080063
56Phenylalanine metabolism_Homo sapiens_hsa003600.87882903
57Regulation of autophagy_Homo sapiens_hsa041400.86684893
58Purine metabolism_Homo sapiens_hsa002300.84597347
59Primary immunodeficiency_Homo sapiens_hsa053400.82073246
60beta-Alanine metabolism_Homo sapiens_hsa004100.81392933
61Glutathione metabolism_Homo sapiens_hsa004800.79161615
62Starch and sucrose metabolism_Homo sapiens_hsa005000.74930244
63Selenocompound metabolism_Homo sapiens_hsa004500.73037825
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69027506
65Metabolic pathways_Homo sapiens_hsa011000.68158234
66Fatty acid elongation_Homo sapiens_hsa000620.68128734
67Antigen processing and presentation_Homo sapiens_hsa046120.66813824
68Sulfur relay system_Homo sapiens_hsa041220.63561417
69PPAR signaling pathway_Homo sapiens_hsa033200.62929878
70Sphingolipid metabolism_Homo sapiens_hsa006000.61088751
71Homologous recombination_Homo sapiens_hsa034400.60182962
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59348104
73Fanconi anemia pathway_Homo sapiens_hsa034600.58835125
74Non-homologous end-joining_Homo sapiens_hsa034500.57678204
75* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57600183
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57495488
77Arginine and proline metabolism_Homo sapiens_hsa003300.56543783
78Legionellosis_Homo sapiens_hsa051340.54897053
79Steroid biosynthesis_Homo sapiens_hsa001000.53588167
80Dilated cardiomyopathy_Homo sapiens_hsa054140.51936033
81p53 signaling pathway_Homo sapiens_hsa041150.51631961
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50103593
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49788625
84N-Glycan biosynthesis_Homo sapiens_hsa005100.46997541
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46576288
86RNA degradation_Homo sapiens_hsa030180.45498098
87Epstein-Barr virus infection_Homo sapiens_hsa051690.44594674
88Mineral absorption_Homo sapiens_hsa049780.44262100
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42697548
90HIF-1 signaling pathway_Homo sapiens_hsa040660.41562779
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39525181
92Nitrogen metabolism_Homo sapiens_hsa009100.38867692
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.35995153
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35815353
95Tyrosine metabolism_Homo sapiens_hsa003500.34909800
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34821474
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.32187097
98Chemical carcinogenesis_Homo sapiens_hsa052040.29801096
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29355236
100Basal transcription factors_Homo sapiens_hsa030220.28998091
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28927440
102Other glycan degradation_Homo sapiens_hsa005110.28346957
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27867785
104Vibrio cholerae infection_Homo sapiens_hsa051100.27753109
105Cyanoamino acid metabolism_Homo sapiens_hsa004600.27339669
106Viral myocarditis_Homo sapiens_hsa054160.27169436
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27158875
108Arginine biosynthesis_Homo sapiens_hsa002200.26649279
109Rheumatoid arthritis_Homo sapiens_hsa053230.23093682
110Viral carcinogenesis_Homo sapiens_hsa052030.22284407
111Apoptosis_Homo sapiens_hsa042100.21823850
112Collecting duct acid secretion_Homo sapiens_hsa049660.21503347
113Phagosome_Homo sapiens_hsa041450.21347662
114Bladder cancer_Homo sapiens_hsa052190.20969404
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.20546265
116Caffeine metabolism_Homo sapiens_hsa002320.20510499
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.19837656
118Shigellosis_Homo sapiens_hsa051310.19226992
119* Insulin signaling pathway_Homo sapiens_hsa049100.18997733
120Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.13962494

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