PRKAG3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of skeletal muscle contraction (GO:0014819)8.45775208
2muscle filament sliding (GO:0030049)8.38855966
3actin-myosin filament sliding (GO:0033275)8.38855966
4skeletal muscle contraction (GO:0003009)8.36877478
5sarcoplasmic reticulum calcium ion transport (GO:0070296)7.56633577
6actin-mediated cell contraction (GO:0070252)7.20783038
7skeletal muscle adaptation (GO:0043501)6.60540214
8response to stimulus involved in regulation of muscle adaptation (GO:0014874)6.26375469
9skeletal muscle fiber development (GO:0048741)6.17959821
10cardiac myofibril assembly (GO:0055003)5.83398156
11myotube cell development (GO:0014904)5.54932935
12negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.50682080
13actin filament-based movement (GO:0030048)5.32434016
14positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.06582072
15positive regulation of myotube differentiation (GO:0010831)4.90981452
16neuronal action potential propagation (GO:0019227)4.83741184
17striated muscle contraction (GO:0006941)4.81924449
18negative regulation of potassium ion transmembrane transport (GO:1901380)4.80889799
19glycogen catabolic process (GO:0005980)4.60887977
20regulation of cell communication by electrical coupling (GO:0010649)4.56831361
21NADH metabolic process (GO:0006734)4.44704149
22response to inactivity (GO:0014854)4.43578934
23striated muscle atrophy (GO:0014891)4.40554179
24glucan catabolic process (GO:0009251)4.33354764
25fructose metabolic process (GO:0006000)4.29885642
26regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.28539804
27regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.25340977
28muscle atrophy (GO:0014889)4.25331589
29sarcomere organization (GO:0045214)4.25124232
30plasma membrane repair (GO:0001778)4.22454829
31myofibril assembly (GO:0030239)4.22388151
32creatine metabolic process (GO:0006600)4.20867300
33regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.17305435
34cardiac muscle hypertrophy (GO:0003300)4.13203067
35response to activity (GO:0014823)4.12095126
36muscle tissue morphogenesis (GO:0060415)4.02787143
37response to muscle activity (GO:0014850)4.01342754
38heart contraction (GO:0060047)4.00396130
39heart process (GO:0003015)4.00396130
40negative regulation of muscle hypertrophy (GO:0014741)3.97584970
41cellular polysaccharide catabolic process (GO:0044247)3.97335051
42striated muscle hypertrophy (GO:0014897)3.94038180
43muscle contraction (GO:0006936)3.91118890
44polysaccharide catabolic process (GO:0000272)3.83544257
45muscle organ morphogenesis (GO:0048644)3.82565577
46skeletal muscle tissue regeneration (GO:0043403)3.76733744
47gluconeogenesis (GO:0006094)3.75439071
48cardiac muscle tissue morphogenesis (GO:0055008)3.75058760
49neuromuscular synaptic transmission (GO:0007274)3.73203242
50striated muscle tissue development (GO:0014706)3.68251915
51striated muscle adaptation (GO:0014888)3.67154303
52positive regulation of myoblast differentiation (GO:0045663)3.64974937
53positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.64581235
54muscle fiber development (GO:0048747)3.64557601
55* glycogen metabolic process (GO:0005977)3.61170785
56* cellular glucan metabolic process (GO:0006073)3.53921154
57* glucan metabolic process (GO:0044042)3.53921154
58muscle system process (GO:0003012)3.53371394
592-oxoglutarate metabolic process (GO:0006103)3.51496900
60muscle hypertrophy (GO:0014896)3.50820076
61negative regulation of calcium ion transmembrane transport (GO:1903170)3.47414460
62negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.47414460
63carnitine shuttle (GO:0006853)3.44096534
64cardiac muscle cell development (GO:0055013)3.41706844
65muscle cell development (GO:0055001)3.40730318
66hexose biosynthetic process (GO:0019319)3.40008870
67muscle structure development (GO:0061061)3.36541842
68muscle organ development (GO:0007517)3.33475861
69regulation of muscle system process (GO:0090257)3.32693268
70mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.30055046
71adult heart development (GO:0007512)3.29830445
72negative regulation of muscle contraction (GO:0045932)3.28939533
73IMP metabolic process (GO:0046040)3.28024568
74regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.25024405
75tricarboxylic acid cycle (GO:0006099)3.22800499
76negative regulation of skeletal muscle tissue development (GO:0048642)3.21898012
77central nervous system myelination (GO:0022010)3.17167862
78axon ensheathment in central nervous system (GO:0032291)3.17167862
79myoblast fusion (GO:0007520)3.15852392
80regulation of striated muscle contraction (GO:0006942)3.14214894
81negative regulation of protein localization to cell surface (GO:2000009)3.12887038
82regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.10691244
83muscle adaptation (GO:0043500)3.07638211
84actomyosin structure organization (GO:0031032)3.06832397
85limb bud formation (GO:0060174)3.04374330
86calcium ion import (GO:0070509)2.99966344
87muscle cell fate commitment (GO:0042693)2.93880064
88pyrimidine ribonucleoside catabolic process (GO:0046133)2.92101435
89regulation of actin filament-based movement (GO:1903115)2.91904350
90regulation of myoblast differentiation (GO:0045661)2.90564462
91membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.87334689
92skeletal muscle tissue development (GO:0007519)2.85232596
93otic vesicle formation (GO:0030916)2.84397034
94muscle cell cellular homeostasis (GO:0046716)2.80537649
95cytidine deamination (GO:0009972)2.78622551
96cytidine metabolic process (GO:0046087)2.78622551
97cytidine catabolic process (GO:0006216)2.78622551
98cellular response to epinephrine stimulus (GO:0071872)2.75279192
99myotube differentiation (GO:0014902)2.74497224
100import into cell (GO:0098657)2.74424787
101regulation of sarcomere organization (GO:0060297)2.73097757
102neuromuscular junction development (GO:0007528)2.72607509
103response to epinephrine (GO:0071871)2.71029041
104positive regulation of protein kinase C signaling (GO:0090037)2.70764521
105fatty acid transmembrane transport (GO:1902001)2.70682827
106cellular carbohydrate catabolic process (GO:0044275)2.69969903
107negative regulation of cardiac muscle hypertrophy (GO:0010614)2.67849674
108syncytium formation by plasma membrane fusion (GO:0000768)2.64159013
109regulation of skeletal muscle cell differentiation (GO:2001014)2.63680997
110neuron fate determination (GO:0048664)2.63417022
111negative regulation of cAMP-mediated signaling (GO:0043951)2.62918025
112cardiac muscle contraction (GO:0060048)2.62128786
113regulation of membrane repolarization (GO:0060306)2.61138982
114* glucan biosynthetic process (GO:0009250)2.60776259
115* glycogen biosynthetic process (GO:0005978)2.60776259
116regulation of calcium ion transmembrane transport (GO:1903169)2.58848984
117regulation of calcium ion transmembrane transporter activity (GO:1901019)2.58848984
118regulation of relaxation of muscle (GO:1901077)2.57889205
119presynaptic membrane assembly (GO:0097105)2.56708700
120negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.54221720
121postsynaptic membrane organization (GO:0001941)2.54115393
122striated muscle cell development (GO:0055002)2.54059707
123cranial nerve morphogenesis (GO:0021602)2.53233696
124cerebral cortex radially oriented cell migration (GO:0021799)2.52173903
125positive regulation of action potential (GO:0045760)2.52171957
126presynaptic membrane organization (GO:0097090)2.51767780
127positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.51307466
128regulation of muscle contraction (GO:0006937)2.49178424
129carnitine transmembrane transport (GO:1902603)2.48841707
130long-chain fatty acid biosynthetic process (GO:0042759)2.47736836
131membrane depolarization during action potential (GO:0086010)2.47560536
132syncytium formation (GO:0006949)2.47191701
133respiratory electron transport chain (GO:0022904)2.46306036
134positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.44165207

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.28152581
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.73865697
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.65339400
4GBX2_23144817_ChIP-Seq_PC3_Human2.98231636
5TBX20_22328084_ChIP-Seq_HEART_Mouse2.93549476
6TBX20_22080862_ChIP-Seq_HEART_Mouse2.93549476
7ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.63170323
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.58195333
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.57069632
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.44860871
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.42085731
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.39864852
13VDR_22108803_ChIP-Seq_LS180_Human2.36235291
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.33359877
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.32112801
16BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.26318367
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.16532690
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.16532690
19* MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.14863040
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.14531114
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.13049113
22CBX2_27304074_Chip-Seq_ESCs_Mouse2.10734706
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.05408347
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02962172
25JARID2_20075857_ChIP-Seq_MESCs_Mouse2.02747083
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.99333972
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.96503142
28* EZH2_27294783_Chip-Seq_ESCs_Mouse1.95021980
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.90990294
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.90657319
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.86126849
32TAF15_26573619_Chip-Seq_HEK293_Human1.85216910
33AR_21572438_ChIP-Seq_LNCaP_Human1.82869270
34* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79713430
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76884986
36* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.74347469
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72992021
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71197776
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71137150
40NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.65128093
41EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.61977601
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.61172034
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.60509070
44GATA4_21415370_ChIP-Seq_HL-1_Mouse1.58163075
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.55681983
46CTCF_27219007_Chip-Seq_Bcells_Human1.54781988
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53985237
48ER_23166858_ChIP-Seq_MCF-7_Human1.52120452
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50656348
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50526841
51TRIM28_21343339_ChIP-Seq_HEK293_Human1.48290264
52DROSHA_22980978_ChIP-Seq_HELA_Human1.48266025
53GATA1_22025678_ChIP-Seq_K562_Human1.46948412
54NFIB_24661679_ChIP-Seq_LUNG_Mouse1.42919369
55ESR1_20079471_ChIP-ChIP_T-47D_Human1.42755226
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42155301
57P300_19829295_ChIP-Seq_ESCs_Human1.42014363
58ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.41127702
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.39708129
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39619568
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.38979780
62* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37957120
63RNF2_27304074_Chip-Seq_NSC_Mouse1.37729846
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.37619462
65FUS_26573619_Chip-Seq_HEK293_Human1.33139621
66TP53_18474530_ChIP-ChIP_U2OS_Human1.32965115
67NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32181340
68* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32025329
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29752831
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29468238
71SMAD4_21799915_ChIP-Seq_A2780_Human1.29253149
72* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.28431129
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27925907
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27076619
75SMC3_22415368_ChIP-Seq_MEFs_Mouse1.27033762
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26819799
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26375022
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26289062
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25954357
80* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25377178
81ZNF274_21170338_ChIP-Seq_K562_Hela1.23679630
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21789317
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.21115197
84ZNF263_19887448_ChIP-Seq_K562_Human1.20171160
85IGF1R_20145208_ChIP-Seq_DFB_Human1.20069668
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19711191
87* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16923829
88SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16312215
89* NFE2_27457419_Chip-Seq_LIVER_Mouse1.16222594
90* EZH2_27294783_Chip-Seq_NPCs_Mouse1.16122825
91E2F1_18555785_Chip-Seq_ESCs_Mouse1.15357202
92SA1_27219007_Chip-Seq_Bcells_Human1.11692694
93LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11123643
94SMAD_19615063_ChIP-ChIP_OVARY_Human1.11102432
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10821495
96* P53_22387025_ChIP-Seq_ESCs_Mouse1.10339360
97GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10197181
98REST_21632747_ChIP-Seq_MESCs_Mouse1.09329902
99TP53_16413492_ChIP-PET_HCT116_Human1.09025315
100* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08990951
101PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08777493
102CTCF_21964334_ChIP-Seq_BJAB-B_Human1.08703541
103SPI1_20517297_ChIP-Seq_HL60_Human1.08633964
104* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08353552
105AR_25329375_ChIP-Seq_VCAP_Human1.07842104
106CBP_20019798_ChIP-Seq_JUKART_Human1.07647728
107IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07647728
108WT1_19549856_ChIP-ChIP_CCG9911_Human1.07594835
109TP53_20018659_ChIP-ChIP_R1E_Mouse1.07294283
110MYC_27129775_Chip-Seq_CORNEA_Mouse1.05929864
111GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.05923771
112P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05753310
113OCT4_20526341_ChIP-Seq_ESCs_Human1.04999600
114* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04255054
115ARNT_22903824_ChIP-Seq_MCF-7_Human1.04115915
116EP300_21415370_ChIP-Seq_HL-1_Mouse1.03901465
117STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.02748776
118CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02743726
119STAT3_23295773_ChIP-Seq_U87_Human1.02713899
120ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02577135
121STAT1_20625510_ChIP-Seq_HELA_Human1.02528167
122RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02407086
123SOX2_21211035_ChIP-Seq_LN229_Gbm1.01180420
124* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.00676008
125KDM2B_26808549_Chip-Seq_REH_Human1.00617900
126ESR1_21235772_ChIP-Seq_MCF-7_Human0.99780718
127CMYC_18555785_Chip-Seq_ESCs_Mouse0.99521072
128TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99406961
129POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99406961
130RARB_27405468_Chip-Seq_BRAIN_Mouse0.99350342
131* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98420385
132PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97934174
133* STAT3_18555785_Chip-Seq_ESCs_Mouse0.97352044
134ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96493696
135NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96354192
136* P300_18555785_Chip-Seq_ESCs_Mouse0.96091613
137TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95702164
138SMAD3_21741376_ChIP-Seq_HESCs_Human0.95251338
139* SOX2_18555785_Chip-Seq_ESCs_Mouse0.94761354
140* CRX_20693478_ChIP-Seq_RETINA_Mouse0.94459729
141CLOCK_20551151_ChIP-Seq_293T_Human0.94296306
142E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.94210334
143TCF4_23295773_ChIP-Seq_U87_Human0.93771616
144* OCT4_18555785_Chip-Seq_ESCs_Mouse0.93667203
145* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93593552
146* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.91410645
147LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91282954
148CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.89767804
149* RXR_22158963_ChIP-Seq_LIVER_Mouse0.89200253
150RAD21_21589869_ChIP-Seq_MESCs_Mouse0.88320724
151STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87915830
152* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86426714
153EGR1_19032775_ChIP-ChIP_M12_Human0.84977472
154NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84053062
155NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84053062
156SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84051195
157GATA1_19941827_ChIP-Seq_MEL_Mouse0.83119602
158DPY_21335234_ChIP-Seq_ESCs_Mouse0.82215166
159GATA6_21074721_ChIP-Seq_CACO-2_Human0.79194105
160SMC1_22415368_ChIP-Seq_MEFs_Mouse0.78852707
161CTCF_27219007_Chip-Seq_ERYTHROID_Human0.77937059
162CTCF_21964334_Chip-Seq_Bcells_Human0.76866802
163EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.75782311
164EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.75416725
165PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.74564806
166HTT_18923047_ChIP-ChIP_STHdh_Human0.73876487
167KLF5_20875108_ChIP-Seq_MESCs_Mouse0.73873592
168* LXR_22158963_ChIP-Seq_LIVER_Mouse0.72687764
169DNAJC2_21179169_ChIP-ChIP_NT2_Human0.72325051
170MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.72233313
171LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.71962713
172TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.71704669
173GATA1_19941827_ChIP-Seq_MEL86_Mouse0.70918344
174* CTCF_26484167_Chip-Seq_Bcells_Mouse0.70635060
175GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.69487997

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio7.22759728
2MP0000749_muscle_degeneration5.23383550
3MP0000751_myopathy4.69457791
4MP0003646_muscle_fatigue4.59189771
5MP0002106_abnormal_muscle_physiology3.42459818
6MP0000747_muscle_weakness3.24927537
7MP0002837_dystrophic_cardiac_calcinosis3.22646933
8MP0004036_abnormal_muscle_relaxation3.14016420
9MP0000759_abnormal_skeletal_muscle3.02262840
10MP0005369_muscle_phenotype2.94289659
11MP0005620_abnormal_muscle_contractility2.79569093
12MP0000750_abnormal_muscle_regeneration2.62993459
13MP0004270_analgesia2.56092599
14MP0004087_abnormal_muscle_fiber2.41673555
15MP0004130_abnormal_muscle_cell2.17410105
16MP0002269_muscular_atrophy2.17198105
17MP0003880_abnormal_central_pattern2.08552644
18MP0002332_abnormal_exercise_endurance2.03190260
19MP0002108_abnormal_muscle_morphology1.83776153
20MP0003136_yellow_coat_color1.80221907
21MP0000733_abnormal_muscle_development1.75217326
22MP0004233_abnormal_muscle_weight1.66220551
23MP0003950_abnormal_plasma_membrane1.64857710
24MP0005330_cardiomyopathy1.53167989
25MP0010630_abnormal_cardiac_muscle1.51726893
26MP0002102_abnormal_ear_morphology1.50744544
27MP0004510_myositis1.49637245
28MP0004215_abnormal_myocardial_fiber1.44805367
29MP0004484_altered_response_of1.43816939
30MP0004142_abnormal_muscle_tone1.36005971
31MP0005266_abnormal_metabolism1.33299733
32MP0002971_abnormal_brown_adipose1.28158856
33MP0001486_abnormal_startle_reflex1.22046037
34MP0004185_abnormal_adipocyte_glucose1.22045478
35MP0001188_hyperpigmentation1.18938547
36MP0001440_abnormal_grooming_behavior1.17300247
37MP0002972_abnormal_cardiac_muscle1.17202999
38MP0003137_abnormal_impulse_conducting1.15639178
39MP0006276_abnormal_autonomic_nervous1.15589869
40MP0004134_abnormal_chest_morphology1.14204279
41MP0004742_abnormal_vestibular_system1.13648425
42MP0005645_abnormal_hypothalamus_physiol1.11696018
43MP0009745_abnormal_behavioral_response1.11592009
44MP0002734_abnormal_mechanical_nocicepti1.10995620
45MP0005409_darkened_coat_color1.09344661
46MP0009250_abnormal_appendicular_skeleto1.09113709
47MP0006036_abnormal_mitochondrial_physio1.08368319
48MP0009046_muscle_twitch1.04458520
49MP0002272_abnormal_nervous_system1.03871837
50MP0004859_abnormal_synaptic_plasticity1.03629071
51MP0004381_abnormal_hair_follicle1.02396470
52MP0005666_abnormal_adipose_tissue1.01076902
53MP0002735_abnormal_chemical_nociception0.99763642
54MP0003635_abnormal_synaptic_transmissio0.98197102
55MP0001661_extended_life_span0.97899927
56MP0002067_abnormal_sensory_capabilities0.97745970
57MP0004084_abnormal_cardiac_muscle0.97343966
58MP0000762_abnormal_tongue_morphology0.93722610
59MP0005171_absent_coat_pigmentation0.93578852
60MP0000372_irregular_coat_pigmentation0.93116792
61MP0000566_synostosis0.91724633
62MP0005451_abnormal_body_composition0.91348132
63MP0000383_abnormal_hair_follicle0.89719026
64MP0002277_abnormal_respiratory_mucosa0.87716488
65MP0005670_abnormal_white_adipose0.86639920
66MP0008775_abnormal_heart_ventricle0.86525055
67MP0002064_seizures0.85724176
68MP0009780_abnormal_chondrocyte_physiolo0.85094694
69MP0002822_catalepsy0.84898019
70MP0001299_abnormal_eye_distance/0.84311451
71MP0000920_abnormal_myelination0.82528651
72MP0005423_abnormal_somatic_nervous0.82148591
73MP0003045_fibrosis0.79421722
74MP0001501_abnormal_sleep_pattern0.78303939
75MP0003828_pulmonary_edema0.78216417
76MP0000003_abnormal_adipose_tissue0.78130171
77MP0004147_increased_porphyrin_level0.77225442
78MP0000026_abnormal_inner_ear0.75231713
79MP0005375_adipose_tissue_phenotype0.74899295
80MP0001727_abnormal_embryo_implantation0.74661344
81MP0003879_abnormal_hair_cell0.73516744
82MP0003959_abnormal_lean_body0.73435759
83MP0002876_abnormal_thyroid_physiology0.73017132
84MP0002066_abnormal_motor_capabilities/c0.71271762
85MP0002184_abnormal_innervation0.70659111
86MP0004043_abnormal_pH_regulation0.70564717
87MP0002572_abnormal_emotion/affect_behav0.70182813
88MP0000778_abnormal_nervous_system0.69461277
89MP0001346_abnormal_lacrimal_gland0.68284496
90MP0001485_abnormal_pinna_reflex0.68172192
91MP0002063_abnormal_learning/memory/cond0.67921306
92MP0002249_abnormal_larynx_morphology0.67598032
93MP0001905_abnormal_dopamine_level0.66043831
94MP0000013_abnormal_adipose_tissue0.65635698
95MP0002638_abnormal_pupillary_reflex0.65120974
96MP0002752_abnormal_somatic_nervous0.65013023
97MP0003221_abnormal_cardiomyocyte_apopto0.63869473
98MP0006138_congestive_heart_failure0.63468448
99MP0005646_abnormal_pituitary_gland0.63168018
100MP0008569_lethality_at_weaning0.62727021
101MP0001529_abnormal_vocalization0.62439652
102MP0006292_abnormal_olfactory_placode0.60490219
103MP0001968_abnormal_touch/_nociception0.59182740
104MP0004085_abnormal_heartbeat0.59057529
105MP0001963_abnormal_hearing_physiology0.58594734
106MP0003938_abnormal_ear_development0.57787171
107MP0003385_abnormal_body_wall0.57414080
108MP0002127_abnormal_cardiovascular_syste0.57305491
109MP0005385_cardiovascular_system_phenoty0.56445177
110MP0001544_abnormal_cardiovascular_syste0.56445177
111MP0000266_abnormal_heart_morphology0.55917840
112MP0010030_abnormal_orbit_morphology0.49316848
113MP0005083_abnormal_biliary_tract0.48792972
114MP0003656_abnormal_erythrocyte_physiolo0.47742134
115* MP0002078_abnormal_glucose_homeostasis0.41511325
116MP0003806_abnormal_nucleotide_metabolis0.41366845
117MP0005166_decreased_susceptibility_to0.41031263
118MP0002114_abnormal_axial_skeleton0.40661476
119MP0005376_homeostasis/metabolism_phenot0.39891559
120MP0005167_abnormal_blood-brain_barrier0.37061897
121MP0005319_abnormal_enzyme/_coenzyme0.36098091
122MP0002896_abnormal_bone_mineralization0.36055954
123MP0005452_abnormal_adipose_tissue0.35981102
124MP0002128_abnormal_blood_circulation0.35742723
125MP0003705_abnormal_hypodermis_morpholog0.34188659
126MP0000230_abnormal_systemic_arterial0.32100737
127MP0009672_abnormal_birth_weight0.31497936
128MP0004858_abnormal_nervous_system0.30414002
129MP0005584_abnormal_enzyme/coenzyme_acti0.29945354
130MP0003279_aneurysm0.27427043
131MP0005332_abnormal_amino_acid0.27063038
132MP0003948_abnormal_gas_homeostasis0.27002339
133MP0005535_abnormal_body_temperature0.26461896
134MP0005165_increased_susceptibility_to0.26359497
135MP0001943_abnormal_respiration0.25498123
136MP0003011_delayed_dark_adaptation0.24115672
137MP0005334_abnormal_fat_pad0.22011405
138MP0006035_abnormal_mitochondrial_morpho0.20412462
139MP0001542_abnormal_bone_strength0.18590581
140MP0002234_abnormal_pharynx_morphology0.16039320
141MP0000343_altered_response_to0.14604944
142MP0003191_abnormal_cellular_cholesterol0.13012070

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)8.45468844
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)8.21943751
3Exercise-induced myalgia (HP:0003738)7.74974987
4Nemaline bodies (HP:0003798)7.70455770
5Muscle hypertrophy of the lower extremities (HP:0008968)7.25210348
6Exercise-induced muscle cramps (HP:0003710)6.72446384
7Distal arthrogryposis (HP:0005684)6.43285671
8Calf muscle hypertrophy (HP:0008981)6.31940909
9Round ear (HP:0100830)6.03999492
10Type 1 muscle fiber predominance (HP:0003803)6.02863008
11Myopathic facies (HP:0002058)5.58304547
12Ulnar deviation of the wrist (HP:0003049)5.18672034
13Difficulty running (HP:0009046)4.90072797
14Muscle fiber splitting (HP:0003555)4.75524750
15Calcaneovalgus deformity (HP:0001848)4.63445571
16Absent phalangeal crease (HP:0006109)4.55964931
17Abnormality of the calf musculature (HP:0001430)4.31827883
18Muscle stiffness (HP:0003552)4.27944356
19Deformed tarsal bones (HP:0008119)4.24633193
20EMG: myopathic abnormalities (HP:0003458)4.18523092
21Hyporeflexia of lower limbs (HP:0002600)4.15496815
22Abnormal finger flexion creases (HP:0006143)3.84441501
23Malignant hyperthermia (HP:0002047)3.82573664
24Myoglobinuria (HP:0002913)3.76186331
25Hyperkalemia (HP:0002153)3.67802262
26Myotonia (HP:0002486)3.60436624
27Abnormality of the left ventricular outflow tract (HP:0011103)3.45248337
28Subaortic stenosis (HP:0001682)3.45248337
29Increased connective tissue (HP:0009025)3.22780314
30Rhabdomyolysis (HP:0003201)3.19207066
31Fetal akinesia sequence (HP:0001989)3.17671605
32Neck muscle weakness (HP:0000467)3.09539857
33Abnormality of skeletal muscle fiber size (HP:0012084)3.02309908
34Abnormality of the neuromuscular junction (HP:0003398)2.93205949
35Fatigable weakness (HP:0003473)2.93205949
36Nonprogressive disorder (HP:0003680)2.86511647
37Muscle fiber atrophy (HP:0100295)2.84002469
38Sudden death (HP:0001699)2.75942741
39Rimmed vacuoles (HP:0003805)2.74149420
40Increased variability in muscle fiber diameter (HP:0003557)2.68665036
41Bundle branch block (HP:0011710)2.65144754
42Shoulder girdle muscle weakness (HP:0003547)2.60949022
43Difficulty climbing stairs (HP:0003551)2.59534604
44Distal lower limb muscle weakness (HP:0009053)2.55622916
45Limb-girdle muscle atrophy (HP:0003797)2.53518281
46Paralysis (HP:0003470)2.50880568
47Abnormality of the musculature of the pelvis (HP:0001469)2.50865475
48Abnormality of the hip-girdle musculature (HP:0001445)2.50865475
49Areflexia of lower limbs (HP:0002522)2.48315565
50Hypoplastic ischia (HP:0003175)2.48070311
51Pelvic girdle muscle weakness (HP:0003749)2.47427893
52Bulbar palsy (HP:0001283)2.42632975
53Focal motor seizures (HP:0011153)2.42618708
54Gowers sign (HP:0003391)2.31250195
55Weak cry (HP:0001612)2.28643384
56Abnormality of the calcaneus (HP:0008364)2.26227275
57Dilated cardiomyopathy (HP:0001644)2.22581689
58Frequent falls (HP:0002359)2.18376205
59Muscular dystrophy (HP:0003560)2.16886504
60Abnormality of the ischium (HP:0003174)2.15648255
61Generalized muscle weakness (HP:0003324)2.14570063
62Popliteal pterygium (HP:0009756)2.12266762
63Slender build (HP:0001533)2.11392441
64Distal lower limb amyotrophy (HP:0008944)2.11367503
65Easy fatigability (HP:0003388)2.08409363
66Lipoatrophy (HP:0100578)2.07598248
67Progressive muscle weakness (HP:0003323)2.02980172
68Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.00861687
69Abnormality of potassium homeostasis (HP:0011042)1.93891192
70Abnormality of the shoulder girdle musculature (HP:0001435)1.93670204
71Parakeratosis (HP:0001036)1.91516636
72EMG: neuropathic changes (HP:0003445)1.87591704
73Broad-based gait (HP:0002136)1.85656636
74Asymmetric septal hypertrophy (HP:0001670)1.83800992
75Scapular winging (HP:0003691)1.80527345
76Type 2 muscle fiber atrophy (HP:0003554)1.79855128
77Facial diplegia (HP:0001349)1.77756545
78Ventricular tachycardia (HP:0004756)1.74792459
79Centrally nucleated skeletal muscle fibers (HP:0003687)1.74657797
80Ulnar deviation of finger (HP:0009465)1.74316259
81Hip contracture (HP:0003273)1.73656805
82Heart block (HP:0012722)1.71788275
83Proximal amyotrophy (HP:0007126)1.71636857
84Abnormality of the foot musculature (HP:0001436)1.71438128
85Aplasia of the musculature (HP:0100854)1.71284186
86Acute necrotizing encephalopathy (HP:0006965)1.69868300
87Thin ribs (HP:0000883)1.69832419
88Pterygium (HP:0001059)1.67680527
89Akinesia (HP:0002304)1.65692616
90Limb-girdle muscle weakness (HP:0003325)1.63407005
91Ventricular arrhythmia (HP:0004308)1.63065170
92Fibular aplasia (HP:0002990)1.63007978
93Abnormal atrioventricular conduction (HP:0005150)1.62442140
94Mildly elevated creatine phosphokinase (HP:0008180)1.61702932
95Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.60854490
96Foot dorsiflexor weakness (HP:0009027)1.60130690
97Metatarsus adductus (HP:0001840)1.59714212
98Nasal speech (HP:0001611)1.57468559
99Bell-shaped thorax (HP:0001591)1.57280010
100Spinal rigidity (HP:0003306)1.54103039
101Limited hip movement (HP:0008800)1.53846352
102Amniotic constriction ring (HP:0009775)1.53846177
103Abnormality of placental membranes (HP:0011409)1.53846177
104Respiratory insufficiency due to muscle weakness (HP:0002747)1.53351083
105Absent/shortened dynein arms (HP:0200106)1.53167325
106Dynein arm defect of respiratory motile cilia (HP:0012255)1.53167325
107Exercise intolerance (HP:0003546)1.52034011
108Atonic seizures (HP:0010819)1.52001991
109Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.48975482
110Febrile seizures (HP:0002373)1.47997116
111Long clavicles (HP:0000890)1.47819286
112Hypoplastic heart (HP:0001961)1.47410821
113Hypokalemia (HP:0002900)1.47116582
114Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.46873065
115Waddling gait (HP:0002515)1.46326259
116Lower limb amyotrophy (HP:0007210)1.46239059
117Ragged-red muscle fibers (HP:0003200)1.38542679
118Short palpebral fissure (HP:0012745)1.31822409
119Cystic hygroma (HP:0000476)1.31417638

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.16999065
2PHKG25.02180566
3PHKG15.02180566
4TTN3.77439276
5NME13.71347426
6PIK3CG3.34186003
7CASK2.99972593
8MUSK2.54353033
9TNIK2.48182471
10BLK2.29089343
11PIK3CA1.88174025
12MAP2K41.73561528
13MAP3K71.70081249
14PKN11.66532341
15MAPK121.57997143
16OXSR11.56850703
17PINK11.46156903
18DMPK1.42511095
19PNCK1.39662007
20INSRR1.38643826
21MAP2K31.36320652
22STK391.36224428
23EPHB11.36023180
24MAPKAPK31.35806026
25GRK71.30523449
26MKNK21.28270397
27LIMK11.24801172
28CCNB11.21759225
29PRKAA21.09205190
30EEF2K0.91882763
31MAP2K70.90913937
32EPHA40.90728982
33MAPK130.84261153
34BCR0.83078465
35NTRK30.81386565
36NEK10.80646252
37FGR0.77657492
38CDK30.77096895
39MAP2K60.75994015
40CAMK1G0.75305236
41CAMK2G0.72758021
42CAMK2A0.69877995
43EIF2AK20.69735361
44PRKG10.69720603
45MAP3K40.69350405
46DYRK1B0.69201762
47NEK60.67526268
48GRK10.67444890
49MOS0.67101629
50MAP3K120.66111943
51BMPR20.63996369
52ADRBK20.63751580
53SGK10.62544985
54MAP2K10.62398415
55BCKDK0.61882304
56CAMK2D0.59976013
57MARK10.58237857
58MAPK110.57452185
59NEK90.56060768
60PDK20.55892936
61MAP3K60.55766304
62SIK20.54754931
63CAMK2B0.54671512
64ZAK0.53811934
65PRKAA10.53246809
66GRK50.53058242
67PTK2B0.52326493
68PRKCE0.52233708
69TRPM70.51823534
70PLK20.51734505
71MAPK150.51603732
72ROCK20.50864084
73IRAK40.48738751
74TRIB30.48448150
75PRKACB0.48444845
76PRKACA0.48233574
77MAPK40.47897158
78CAMK40.47624293
79PAK60.47614144
80WNK10.47497609
81MAPK70.46438132
82IRAK10.46060398
83SIK30.45739383
84IRAK30.44638704
85PDK30.44406451
86PDK40.44406451
87MARK20.43412886
88AKT20.43402749
89SGK30.43347433
90RIPK10.42943766
91WNK40.42148970
92BMPR1B0.42121422
93MAP3K130.41030717
94STK160.40127843
95CDK190.39368853
96ADRBK10.38755530
97MKNK10.38476481
98ICK0.37897593
99EPHB20.36953147
100SIK10.36770159
101TIE10.36455745
102IRAK20.36164070
103FER0.35813149
104LATS20.35669886
105PRKCQ0.34915786
106STK110.34739742
107CDK50.34055650
108RIPK40.33864526
109NTRK20.33723478
110TNK20.33362680
111TBK10.32996134
112KSR20.32839262
113ERBB30.32018932
114MAP3K140.31250126
115PAK30.30635573
116SGK20.29558075
117CAMK10.28621393
118DYRK1A0.28288459
119RPS6KA30.27609167
120ROCK10.27524069
121FES0.26429989
122MAPK100.24205947
123MAP3K10.23120794
124RPS6KB10.22311541
125PDPK10.21883090
126TAOK20.21770059
127DAPK20.20985892
128MAP3K100.16776518
129CDK80.16334000
130RPS6KA10.15904943
131PDK10.14481149
132ARAF0.13794705
133MAP3K50.13104971
134RPS6KB20.12471692
135MAP3K110.12090268
136ZAP700.11928189
137MTOR0.11012059
138PRKACG0.10350746
139RPS6KL10.09587552
140RPS6KC10.09587552
141PRKD10.08199438
142TGFBR20.08065019
143SGK2230.07463623
144SGK4940.07463623
145RPS6KA60.05955489
146MARK30.04675385
147ILK0.03286464
148MAPK80.03235650
149RPS6KA20.02699588
150RAF10.02629096
151CSNK1D0.02567171
152PRPF4B0.02527851
153PAK10.01725692

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042603.55178524
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.52611071
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.22400341
4* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.21498735
5Dilated cardiomyopathy_Homo sapiens_hsa054142.96196027
6Oxidative phosphorylation_Homo sapiens_hsa001902.95275858
7Calcium signaling pathway_Homo sapiens_hsa040202.41006664
8Alzheimers disease_Homo sapiens_hsa050102.39062467
9Nicotine addiction_Homo sapiens_hsa050332.35632858
10Pentose phosphate pathway_Homo sapiens_hsa000302.26619851
11Parkinsons disease_Homo sapiens_hsa050122.24047733
12Carbon metabolism_Homo sapiens_hsa012002.18646876
13* Oxytocin signaling pathway_Homo sapiens_hsa049212.02489185
14Fructose and mannose metabolism_Homo sapiens_hsa000511.94173322
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.91902772
16Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.79339952
17Starch and sucrose metabolism_Homo sapiens_hsa005001.76085686
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.73856900
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68383271
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.64086567
21Arginine biosynthesis_Homo sapiens_hsa002201.60677270
22* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.55795174
23Serotonergic synapse_Homo sapiens_hsa047261.50190825
24GABAergic synapse_Homo sapiens_hsa047271.48115828
25Fatty acid elongation_Homo sapiens_hsa000621.46316154
26Renin secretion_Homo sapiens_hsa049241.44560718
27Phototransduction_Homo sapiens_hsa047441.44108907
28Glutamatergic synapse_Homo sapiens_hsa047241.42887663
29Gastric acid secretion_Homo sapiens_hsa049711.42730180
30Morphine addiction_Homo sapiens_hsa050321.37816077
31Vascular smooth muscle contraction_Homo sapiens_hsa042701.35422418
32Propanoate metabolism_Homo sapiens_hsa006401.34481686
33Taste transduction_Homo sapiens_hsa047421.34248299
34Huntingtons disease_Homo sapiens_hsa050161.33400337
35Fatty acid degradation_Homo sapiens_hsa000711.32198202
36Arginine and proline metabolism_Homo sapiens_hsa003301.28800226
37cGMP-PKG signaling pathway_Homo sapiens_hsa040221.27276606
38Axon guidance_Homo sapiens_hsa043601.26678319
39Circadian entrainment_Homo sapiens_hsa047131.21690340
40Biosynthesis of amino acids_Homo sapiens_hsa012301.20951842
41* Glucagon signaling pathway_Homo sapiens_hsa049221.19340100
42Salivary secretion_Homo sapiens_hsa049701.17643334
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16497293
44Long-term depression_Homo sapiens_hsa047301.12790160
45Insulin secretion_Homo sapiens_hsa049111.09003594
46Tight junction_Homo sapiens_hsa045301.08844635
47GnRH signaling pathway_Homo sapiens_hsa049121.07344815
48Nitrogen metabolism_Homo sapiens_hsa009101.07282219
49Ether lipid metabolism_Homo sapiens_hsa005651.06868811
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00930480
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98679806
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97720774
53Collecting duct acid secretion_Homo sapiens_hsa049660.97712169
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94181901
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92278212
56* Circadian rhythm_Homo sapiens_hsa047100.90554747
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89479205
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85081029
59Cholinergic synapse_Homo sapiens_hsa047250.83920127
60Galactose metabolism_Homo sapiens_hsa000520.82916975
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82644602
62MAPK signaling pathway_Homo sapiens_hsa040100.82570519
63* Insulin signaling pathway_Homo sapiens_hsa049100.81604065
64Melanogenesis_Homo sapiens_hsa049160.77680125
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77301296
66Olfactory transduction_Homo sapiens_hsa047400.77278736
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74525932
68cAMP signaling pathway_Homo sapiens_hsa040240.73552997
69Amphetamine addiction_Homo sapiens_hsa050310.73025800
70Phenylalanine metabolism_Homo sapiens_hsa003600.72465172
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72110918
72Autoimmune thyroid disease_Homo sapiens_hsa053200.71469588
73Sphingolipid metabolism_Homo sapiens_hsa006000.67648772
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67438830
75Sulfur metabolism_Homo sapiens_hsa009200.67250293
76Long-term potentiation_Homo sapiens_hsa047200.67068286
77Basal cell carcinoma_Homo sapiens_hsa052170.65015441
78Wnt signaling pathway_Homo sapiens_hsa043100.62828030
79Dopaminergic synapse_Homo sapiens_hsa047280.60689644
80Pancreatic secretion_Homo sapiens_hsa049720.58403601
81Arachidonic acid metabolism_Homo sapiens_hsa005900.57925527
82* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56681050
83Linoleic acid metabolism_Homo sapiens_hsa005910.55742671
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54852112
85* AMPK signaling pathway_Homo sapiens_hsa041520.54595487
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54496429
87Dorso-ventral axis formation_Homo sapiens_hsa043200.53824522
88Ovarian steroidogenesis_Homo sapiens_hsa049130.53381076
89Ras signaling pathway_Homo sapiens_hsa040140.52575134
90PPAR signaling pathway_Homo sapiens_hsa033200.51924482
91Focal adhesion_Homo sapiens_hsa045100.51862485
92Histidine metabolism_Homo sapiens_hsa003400.51226273
93Fatty acid biosynthesis_Homo sapiens_hsa000610.50444888
94Butanoate metabolism_Homo sapiens_hsa006500.49845380
95* Adipocytokine signaling pathway_Homo sapiens_hsa049200.48690251
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48655255
97Hedgehog signaling pathway_Homo sapiens_hsa043400.48284205
98Viral myocarditis_Homo sapiens_hsa054160.47198878
99beta-Alanine metabolism_Homo sapiens_hsa004100.46691246
100Pyruvate metabolism_Homo sapiens_hsa006200.46515026
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44377693
102Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43315131
103ErbB signaling pathway_Homo sapiens_hsa040120.42924841
104Rheumatoid arthritis_Homo sapiens_hsa053230.42468070
105* Insulin resistance_Homo sapiens_hsa049310.40828751
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40220224
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39856889
108* FoxO signaling pathway_Homo sapiens_hsa040680.39687633
109Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39494039
110Tryptophan metabolism_Homo sapiens_hsa003800.39114416
111Peroxisome_Homo sapiens_hsa041460.37693114
112Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36812024
113Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36222995
114Type II diabetes mellitus_Homo sapiens_hsa049300.35587446
115Cocaine addiction_Homo sapiens_hsa050300.32331749
116Regulation of autophagy_Homo sapiens_hsa041400.32304858
117Choline metabolism in cancer_Homo sapiens_hsa052310.31116412
1182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31108929
119Fatty acid metabolism_Homo sapiens_hsa012120.29933285
120Phagosome_Homo sapiens_hsa041450.29857747
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29613423
122Metabolic pathways_Homo sapiens_hsa011000.29437798
123Amoebiasis_Homo sapiens_hsa051460.29396394
124Gap junction_Homo sapiens_hsa045400.28970718
125Lysine degradation_Homo sapiens_hsa003100.26798657
126Platelet activation_Homo sapiens_hsa046110.24891429
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.24089542
128Glioma_Homo sapiens_hsa052140.23630076
129HIF-1 signaling pathway_Homo sapiens_hsa040660.22820800
130* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22251892
131VEGF signaling pathway_Homo sapiens_hsa043700.21607104
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.20720762
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19223881
134mTOR signaling pathway_Homo sapiens_hsa041500.18727461
135Leukocyte transendothelial migration_Homo sapiens_hsa046700.18628091
136Adherens junction_Homo sapiens_hsa045200.18546907
137Purine metabolism_Homo sapiens_hsa002300.16907368
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.11401059
139Sulfur relay system_Homo sapiens_hsa041220.10823105
140Tyrosine metabolism_Homo sapiens_hsa003500.09494795
141Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.08107587

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