PRKAR1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.72507981
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.31279934
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.23420847
4regulation of synaptic vesicle exocytosis (GO:2000300)5.01086222
5synaptic vesicle exocytosis (GO:0016079)4.94949830
6locomotory exploration behavior (GO:0035641)4.73057172
7glutamate secretion (GO:0014047)4.71501027
8synaptic vesicle docking involved in exocytosis (GO:0016081)4.62773791
9regulation of synaptic vesicle transport (GO:1902803)4.38808915
10neurotransmitter secretion (GO:0007269)4.02209859
11vocalization behavior (GO:0071625)4.01444756
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.96412857
13regulation of synapse structural plasticity (GO:0051823)3.93181628
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.80295505
15cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.80047606
16regulation of glutamate receptor signaling pathway (GO:1900449)3.72989878
17layer formation in cerebral cortex (GO:0021819)3.58649865
18cell communication by electrical coupling (GO:0010644)3.56476860
19exploration behavior (GO:0035640)3.56434138
20cellular potassium ion homeostasis (GO:0030007)3.52095094
21proline transport (GO:0015824)3.49685472
22regulation of neuronal synaptic plasticity (GO:0048168)3.48619503
23* activation of protein kinase A activity (GO:0034199)3.48566849
24membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.47900208
25Golgi transport vesicle coating (GO:0048200)3.47786307
26COPI coating of Golgi vesicle (GO:0048205)3.47786307
27neuronal action potential propagation (GO:0019227)3.46866340
28sodium ion export (GO:0071436)3.45431151
29regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.44751248
30protein localization to synapse (GO:0035418)3.44251477
31neuron cell-cell adhesion (GO:0007158)3.41720520
32regulation of long-term neuronal synaptic plasticity (GO:0048169)3.30587815
33positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.27784665
34vesicle transport along microtubule (GO:0047496)3.24909083
35protein localization to endosome (GO:0036010)3.18310403
36cerebellar Purkinje cell layer development (GO:0021680)3.18146082
37detection of calcium ion (GO:0005513)3.17872936
38positive regulation of synaptic transmission, GABAergic (GO:0032230)3.16124667
39positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.15660315
40cerebellar Purkinje cell differentiation (GO:0021702)3.13392710
41neurotransmitter transport (GO:0006836)3.10374262
42neuromuscular process controlling posture (GO:0050884)3.09934068
43regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.04486298
44regulation of neurotransmitter secretion (GO:0046928)3.02783583
45regulation of vesicle fusion (GO:0031338)3.01674638
46positive regulation of synapse maturation (GO:0090129)3.00192984
47innervation (GO:0060384)2.98781017
48neurotransmitter-gated ion channel clustering (GO:0072578)2.98118953
49membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.97935591
50membrane depolarization during action potential (GO:0086010)2.96719690
51negative regulation of complement activation (GO:0045916)2.94409560
52negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.93700567
53membrane repolarization (GO:0086009)2.92318269
54organelle transport along microtubule (GO:0072384)2.91841329
55ionotropic glutamate receptor signaling pathway (GO:0035235)2.91443355
56positive regulation of potassium ion transmembrane transport (GO:1901381)2.91074729
57response to pheromone (GO:0019236)2.90812088
58macroautophagy (GO:0016236)2.90271400
59glycine transport (GO:0015816)2.87977643
60synaptic transmission, glutamatergic (GO:0035249)2.87951202
61regulation of ARF protein signal transduction (GO:0032012)2.87302835
62neuron-neuron synaptic transmission (GO:0007270)2.86021854
63potassium ion import (GO:0010107)2.85840550
64regulation of neurotransmitter levels (GO:0001505)2.84232417
65long-term memory (GO:0007616)2.83704369
66synaptic vesicle endocytosis (GO:0048488)2.82828739
67gamma-aminobutyric acid transport (GO:0015812)2.81648536
68long-term synaptic potentiation (GO:0060291)2.81612208
69regulation of synaptic plasticity (GO:0048167)2.81510541
70regulation of neurotransmitter transport (GO:0051588)2.80825054
71dendrite morphogenesis (GO:0048813)2.80576487
72positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.80571184
73negative regulation of humoral immune response (GO:0002921)2.79819021
74nerve growth factor signaling pathway (GO:0038180)2.79339625
75negative regulation of microtubule polymerization (GO:0031115)2.77723245
76regulation of excitatory postsynaptic membrane potential (GO:0060079)2.77380660
77positive regulation of membrane potential (GO:0045838)2.76709587
78neuromuscular process controlling balance (GO:0050885)2.76529882
79negative regulation of protein activation cascade (GO:2000258)2.76421025
80regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.74567827
81positive regulation of potassium ion transport (GO:0043268)2.74182993
82regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.73304448
83cellular response to monoamine stimulus (GO:0071868)2.72761227
84cellular response to catecholamine stimulus (GO:0071870)2.72761227
85regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.70422605
86cell communication involved in cardiac conduction (GO:0086065)2.70335674
87positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.70020704
88mating behavior (GO:0007617)2.68393077
89positive regulation of vesicle fusion (GO:0031340)2.68342842
90axon cargo transport (GO:0008088)2.68191856
91insulin secretion (GO:0030073)2.67644389
92regulation of postsynaptic membrane potential (GO:0060078)2.66931008
93regulation of calcium ion-dependent exocytosis (GO:0017158)2.66615545
94dendritic spine morphogenesis (GO:0060997)2.65979529
95membrane repolarization during action potential (GO:0086011)2.65537782
96regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.64999606
97regulation of cell communication by electrical coupling (GO:0010649)2.64617800
98G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.64454780
99neuron recognition (GO:0008038)2.64423598
100signal release (GO:0023061)2.63553283
101regulation of membrane repolarization (GO:0060306)2.61743996
102cellular sodium ion homeostasis (GO:0006883)2.61701686
103potassium ion homeostasis (GO:0055075)2.61519755
104retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.60627455
105suckling behavior (GO:0001967)2.60445310
106regulation of synaptic transmission, glutamatergic (GO:0051966)2.58229360
107response to catecholamine (GO:0071869)2.57649148
108response to monoamine (GO:0071867)2.57649148
109glutamate receptor signaling pathway (GO:0007215)2.56766107
110postsynaptic membrane organization (GO:0001941)2.56686324
111regulation of calcium ion transmembrane transporter activity (GO:1901019)2.55709791
112regulation of calcium ion transmembrane transport (GO:1903169)2.55709791
113positive regulation of neurotransmitter transport (GO:0051590)2.55120262
114cytoskeletal anchoring at plasma membrane (GO:0007016)2.50842680
115cellular response to epinephrine stimulus (GO:0071872)2.49805299
116positive regulation of receptor recycling (GO:0001921)2.48139300
117regulation of beta-amyloid formation (GO:1902003)2.44014807
118response to epinephrine (GO:0071871)2.37729291
119regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.36144576
120axonemal dynein complex assembly (GO:0070286)2.33516336
121Golgi to endosome transport (GO:0006895)2.30687838
122clathrin coat assembly (GO:0048268)2.28656012
123regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.28549836
124cilium or flagellum-dependent cell motility (GO:0001539)2.27487449
125vesicle coating (GO:0006901)2.24527306
126establishment of nucleus localization (GO:0040023)2.24104357
127cellular response to prostaglandin stimulus (GO:0071379)2.23009505
128positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.22960419
129regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.21686868
130relaxation of cardiac muscle (GO:0055119)2.19644673
131surfactant homeostasis (GO:0043129)2.17016361
132positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.16639058
133growth hormone receptor signaling pathway (GO:0060396)2.16351443
134regulation of actin filament-based movement (GO:1903115)2.14278332
135regulation of cardiac muscle cell contraction (GO:0086004)2.14066191
136cellular response to growth hormone stimulus (GO:0071378)2.13140614
137regulation of amyloid precursor protein catabolic process (GO:1902991)2.12738842
138cerebellar granule cell differentiation (GO:0021707)2.12242956
139Golgi to plasma membrane protein transport (GO:0043001)2.11645815
140negative regulation of immunoglobulin mediated immune response (GO:0002890)2.06619663
141negative regulation of B cell mediated immunity (GO:0002713)2.06619663
142cell adhesion mediated by integrin (GO:0033627)2.03975689
143Golgi to plasma membrane transport (GO:0006893)2.03439531
144regulation of receptor recycling (GO:0001919)2.01149388
145regulation of clathrin-mediated endocytosis (GO:2000369)2.00766125
146regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.00347166
147cellular response to antibiotic (GO:0071236)1.97991202
148iron ion import (GO:0097286)1.97440655
149positive regulation of cardiac muscle hypertrophy (GO:0010613)1.96110142
150positive regulation of muscle hypertrophy (GO:0014742)1.96110142
151negative regulation of protein localization to plasma membrane (GO:1903077)1.95716652
152import into cell (GO:0098657)1.94029900
153neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)1.93917427
154polyol transport (GO:0015791)1.91606624
155cardiac muscle contraction (GO:0060048)1.91490572
156positive regulation of insulin receptor signaling pathway (GO:0046628)1.90648037
157regulation of complement activation (GO:0030449)1.88735777
158positive regulation of cellular amide metabolic process (GO:0034250)1.88202777
159embryonic retina morphogenesis in camera-type eye (GO:0060059)1.86633034
160negative regulation of neurotransmitter secretion (GO:0046929)1.86483559
161COPII vesicle coating (GO:0048208)1.85817603
162response to stimulus involved in regulation of muscle adaptation (GO:0014874)1.85450125
163regulation of steroid hormone biosynthetic process (GO:0090030)1.84625913
164cilium movement (GO:0003341)1.83484627
165adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)1.83281650
166phosphatidylinositol dephosphorylation (GO:0046856)1.81164312

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.06770036
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.93030636
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.90409031
4GBX2_23144817_ChIP-Seq_PC3_Human2.81507622
5RARB_27405468_Chip-Seq_BRAIN_Mouse2.63968366
6REST_21632747_ChIP-Seq_MESCs_Mouse2.59157579
7DROSHA_22980978_ChIP-Seq_HELA_Human2.53421946
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.51287704
9SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50057397
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48323614
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.48007256
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.48007256
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.45755565
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42775279
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.36732711
16REST_18959480_ChIP-ChIP_MESCs_Mouse2.36018631
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.25507517
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.14719723
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.12041797
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11410276
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.07242215
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.03518645
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.00598474
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.98361615
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.94753721
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.94470091
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.93813168
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.92069719
29WT1_19549856_ChIP-ChIP_CCG9911_Human1.90802724
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.89785929
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.89273974
32* CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.88954352
33CLOCK_20551151_ChIP-Seq_293T_Human1.86596981
34* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85169508
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84473621
36NR3C1_23031785_ChIP-Seq_PC12_Mouse1.79987432
37NRF2_20460467_ChIP-Seq_MEFs_Mouse1.71529917
38NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.71529917
39Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.58658389
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.54781275
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53695829
42DNAJC2_21179169_ChIP-ChIP_NT2_Human1.53336752
43SMAD4_21799915_ChIP-Seq_A2780_Human1.51689886
44TRIM28_21343339_ChIP-Seq_HEK293_Human1.51273580
45AR_21572438_ChIP-Seq_LNCaP_Human1.49112532
46* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.47620651
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.47299815
48ZNF274_21170338_ChIP-Seq_K562_Hela1.45087935
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44983598
50* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42418558
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.39829345
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39519150
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38805663
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36648798
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.35838030
56TP53_16413492_ChIP-PET_HCT116_Human1.35306378
57* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.34436199
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34105225
59SALL4_18804426_ChIP-ChIP_XEN_Mouse1.33420239
60TCF4_18268006_ChIP-ChIP_LS174T_Human1.32592391
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30305231
62KDM2B_26808549_Chip-Seq_K562_Human1.30015602
63WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29507927
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29485366
65FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27755287
66ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.27407112
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26600907
68FOXO3_23340844_ChIP-Seq_DLD1_Human1.25761387
69AR_19668381_ChIP-Seq_PC3_Human1.24463068
70FOXA2_19822575_ChIP-Seq_HepG2_Human1.23648628
71FOXM1_26456572_ChIP-Seq_MCF-7_Human1.23539992
72ERG_21242973_ChIP-ChIP_JURKAT_Human1.22845228
73RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20534079
74DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19875994
75TP53_18474530_ChIP-ChIP_U2OS_Human1.19688833
76PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.19567614
77TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19054727
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18788478
79STAT3_23295773_ChIP-Seq_U87_Human1.18025100
80RING1B_27294783_Chip-Seq_ESCs_Mouse1.17944347
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17156089
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.15659687
83TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13648085
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12760210
85ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12700667
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12389683
87EP300_21415370_ChIP-Seq_HL-1_Mouse1.11960578
88TAF15_26573619_Chip-Seq_HEK293_Human1.11379033
89CJUN_26792858_Chip-Seq_BT549_Human1.10989878
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10378542
91CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10075202
92AR_25329375_ChIP-Seq_VCAP_Human1.08920730
93SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08600127
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08211095
95* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07770758
96PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07715651
97* TBX20_22080862_ChIP-Seq_HEART_Mouse1.07207064
98* TBX20_22328084_ChIP-Seq_HEART_Mouse1.07207064
99CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.05625975
100SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.05049895
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04242428
102TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03680274
103OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.03378055
104SOX2_20726797_ChIP-Seq_SW620_Human1.01911973
105TP63_23658742_ChIP-Seq_EP156T_Human1.01677156
106SMAD3_21741376_ChIP-Seq_ESCs_Human1.01395988
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00967836
108TET1_21490601_ChIP-Seq_MESCs_Mouse0.99658735
109CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99444286
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99096659
111ESR2_21235772_ChIP-Seq_MCF-7_Human0.98962052
112* P300_19829295_ChIP-Seq_ESCs_Human0.98592580
113IGF1R_20145208_ChIP-Seq_DFB_Human0.98581374
114SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98213473
115TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97875963
116SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97585260
117SMAD4_21741376_ChIP-Seq_HESCs_Human0.97541800
118CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97105388
119E2F1_18555785_Chip-Seq_ESCs_Mouse0.97033558
120ARNT_22903824_ChIP-Seq_MCF-7_Human0.96553038
121TCF4_23295773_ChIP-Seq_U87_Human0.96291275
122P53_22387025_ChIP-Seq_ESCs_Mouse0.95969218
123NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95078589
124KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95045121
125PIAS1_25552417_ChIP-Seq_VCAP_Human0.94771836
126AHR_22903824_ChIP-Seq_MCF-7_Human0.94757029
127TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94587709
128CMYC_18555785_Chip-Seq_ESCs_Mouse0.94180070
129SMAD3_21741376_ChIP-Seq_EPCs_Human0.93948821
130PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93220748
131ESR1_21235772_ChIP-Seq_MCF-7_Human0.93061940
132SMAD3_21741376_ChIP-Seq_HESCs_Human0.92405707
133P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90458753
134RING1B_27294783_Chip-Seq_NPCs_Mouse0.89883298
135PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89416735
136LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89326874
137SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89060897
138BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88607572
139RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87012288
140MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86849290
141RXR_22108803_ChIP-Seq_LS180_Human0.82926605
142* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.82104034
143CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82081242
144TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.81900655
145EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.81705510
146SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81530764
147AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81106688
148NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81106316
149BCAT_22108803_ChIP-Seq_LS180_Human0.80463206
150THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.80177355

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.45489794
2MP0003635_abnormal_synaptic_transmissio3.62407346
3MP0003880_abnormal_central_pattern3.41294447
4MP0004270_analgesia3.39156917
5MP0009780_abnormal_chondrocyte_physiolo3.00350825
6MP0002063_abnormal_learning/memory/cond2.80130271
7MP0009745_abnormal_behavioral_response2.75147359
8MP0002064_seizures2.66166220
9MP0001968_abnormal_touch/_nociception2.55966824
10MP0010234_abnormal_vibrissa_follicle2.52771300
11MP0009046_muscle_twitch2.44691843
12MP0002734_abnormal_mechanical_nocicepti2.42556262
13* MP0002909_abnormal_adrenal_gland2.36758214
14MP0003122_maternal_imprinting2.34992162
15MP0002572_abnormal_emotion/affect_behav2.32283361
16MP0005248_abnormal_Harderian_gland2.28248415
17MP0002837_dystrophic_cardiac_calcinosis2.28066875
18MP0002822_catalepsy2.26847081
19MP0002272_abnormal_nervous_system2.17925566
20MP0004858_abnormal_nervous_system2.13931214
21MP0002735_abnormal_chemical_nociception2.10522361
22MP0003690_abnormal_glial_cell2.06291502
23MP0002733_abnormal_thermal_nociception2.01940824
24MP0005423_abnormal_somatic_nervous1.98521279
25MP0004272_abnormal_basement_membrane1.97770709
26MP0001970_abnormal_pain_threshold1.90420237
27MP0000751_myopathy1.89687659
28MP0008569_lethality_at_weaning1.89493354
29MP0005409_darkened_coat_color1.87767489
30MP0001501_abnormal_sleep_pattern1.86735132
31MP0008438_abnormal_cutaneous_collagen1.85335742
32MP0002736_abnormal_nociception_after1.85263651
33MP0004811_abnormal_neuron_physiology1.80085925
34MP0003566_abnormal_cell_adhesion1.76010930
35MP0003329_amyloid_beta_deposits1.73525023
36MP0005645_abnormal_hypothalamus_physiol1.71683915
37MP0001486_abnormal_startle_reflex1.71606145
38MP0002067_abnormal_sensory_capabilities1.71434165
39MP0010386_abnormal_urinary_bladder1.71285901
40MP0005646_abnormal_pituitary_gland1.70954542
41MP0002184_abnormal_innervation1.70950012
42MP0003283_abnormal_digestive_organ1.68732012
43MP0001958_emphysema1.67487314
44MP0003183_abnormal_peptide_metabolism1.64740089
45MP0008961_abnormal_basal_metabolism1.64090646
46MP0006276_abnormal_autonomic_nervous1.63623121
47MP0003300_gastrointestinal_ulcer1.60436379
48MP0003191_abnormal_cellular_cholesterol1.59135949
49MP0001440_abnormal_grooming_behavior1.58948358
50MP0003724_increased_susceptibility_to1.58497526
51MP0003787_abnormal_imprinting1.54898445
52MP0003632_abnormal_nervous_system1.53787553
53MP0004924_abnormal_behavior1.52957613
54MP0005386_behavior/neurological_phenoty1.52957613
55* MP0003091_abnormal_cell_migration1.52733588
56MP0002557_abnormal_social/conspecific_i1.52203666
57MP0003879_abnormal_hair_cell1.51625188
58* MP0000013_abnormal_adipose_tissue1.48968824
59MP0003221_abnormal_cardiomyocyte_apopto1.48886699
60MP0001502_abnormal_circadian_rhythm1.48525669
61MP0000955_abnormal_spinal_cord1.48081261
62MP0008260_abnormal_autophagy1.48006427
63MP0003828_pulmonary_edema1.47565129
64MP0010678_abnormal_skin_adnexa1.45105254
65MP0002009_preneoplasia1.43192323
66MP0000920_abnormal_myelination1.38053006
67MP0003633_abnormal_nervous_system1.36195775
68MP0004215_abnormal_myocardial_fiber1.34008667
69MP0004084_abnormal_cardiac_muscle1.33941322
70MP0006054_spinal_hemorrhage1.33428041
71MP0001984_abnormal_olfaction1.29480503
72MP0004043_abnormal_pH_regulation1.28021772
73MP0002877_abnormal_melanocyte_morpholog1.26104380
74MP0004233_abnormal_muscle_weight1.23967757
75MP0002066_abnormal_motor_capabilities/c1.23595465
76MP0000778_abnormal_nervous_system1.21595900
77MP0002882_abnormal_neuron_morphology1.20900684
78MP0004885_abnormal_endolymph1.20146371
79MP0008004_abnormal_stomach_pH1.19406040
80MP0004145_abnormal_muscle_electrophysio1.19210477
81MP0005408_hypopigmentation1.18343642
82MP0002332_abnormal_exercise_endurance1.18256059
83MP0003656_abnormal_erythrocyte_physiolo1.17443535
84MP0005167_abnormal_blood-brain_barrier1.15434541
85MP0004036_abnormal_muscle_relaxation1.14767505
86MP0004883_abnormal_blood_vessel1.14190099
87MP0005058_abnormal_lysosome_morphology1.12665004
88MP0000465_gastrointestinal_hemorrhage1.12549894
89MP0001299_abnormal_eye_distance/1.11405662
90MP0001915_intracranial_hemorrhage1.10254157
91MP0002133_abnormal_respiratory_system1.09906049
92MP0005388_respiratory_system_phenotype1.09906049
93* MP0004085_abnormal_heartbeat1.09360119
94MP0006138_congestive_heart_failure1.08872164
95MP0005171_absent_coat_pigmentation1.08179250
96MP0005164_abnormal_response_to1.05795211
97MP0005623_abnormal_meninges_morphology1.04170108
98MP0005257_abnormal_intraocular_pressure1.01613655
99MP0005165_increased_susceptibility_to1.01020832
100MP0005275_abnormal_skin_tensile1.00870052
101MP0003172_abnormal_lysosome_physiology0.99370684
102MP0003631_nervous_system_phenotype0.97505154
103MP0002638_abnormal_pupillary_reflex0.97239552
104MP0001177_atelectasis0.95470647
105MP0002693_abnormal_pancreas_physiology0.94240795
106MP0001944_abnormal_pancreas_morphology0.93889013
107MP0000747_muscle_weakness0.92131947
108MP0010368_abnormal_lymphatic_system0.91830706
109MP0002069_abnormal_eating/drinking_beha0.90334854
110MP0004510_myositis0.90258215
111MP0005535_abnormal_body_temperature0.89530204
112MP0004130_abnormal_muscle_cell0.89335879
113MP0003634_abnormal_glial_cell0.89316805
114MP0001905_abnormal_dopamine_level0.88954604
115MP0000383_abnormal_hair_follicle0.88832687
116MP0010630_abnormal_cardiac_muscle0.87806718
117MP0002971_abnormal_brown_adipose0.85401553
118MP0002152_abnormal_brain_morphology0.85195163
119MP0000569_abnormal_digit_pigmentation0.84714768
120MP0001879_abnormal_lymphatic_vessel0.84232288
121* MP0002896_abnormal_bone_mineralization0.83970517
122MP0002234_abnormal_pharynx_morphology0.82497557
123MP0001348_abnormal_lacrimal_gland0.81894614
124MP0002229_neurodegeneration0.81717132
125MP0002972_abnormal_cardiac_muscle0.80990131
126MP0003137_abnormal_impulse_conducting0.80822218
127MP0002090_abnormal_vision0.80428900
128MP0002078_abnormal_glucose_homeostasis0.80163188
129MP0003115_abnormal_respiratory_system0.78256376
130MP0006072_abnormal_retinal_apoptosis0.78157471
131MP0004484_altered_response_of0.77888229
132MP0003045_fibrosis0.77664098
133MP0000749_muscle_degeneration0.76975168
134MP0001529_abnormal_vocalization0.76919025
135MP0001851_eye_inflammation0.76148533
136MP0005330_cardiomyopathy0.75267913
137MP0001544_abnormal_cardiovascular_syste0.74926123
138MP0005385_cardiovascular_system_phenoty0.74926123
139MP0005620_abnormal_muscle_contractility0.72847004
140MP0000631_abnormal_neuroendocrine_gland0.71924601
141* MP0002269_muscular_atrophy0.71316936
142MP0004142_abnormal_muscle_tone0.69386593
143MP0005187_abnormal_penis_morphology0.68553586
144MP0000604_amyloidosis0.65572840
145MP0005379_endocrine/exocrine_gland_phen0.64242378
146MP0002751_abnormal_autonomic_nervous0.63163478
147MP0003123_paternal_imprinting0.63062038
148* MP0000003_abnormal_adipose_tissue0.61189237
149MP0000534_abnormal_ureter_morphology0.60456974
150MP0004087_abnormal_muscle_fiber0.59459560

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.13675185
2Myokymia (HP:0002411)4.81905073
3Visual hallucinations (HP:0002367)4.58116736
4Focal seizures (HP:0007359)4.22759996
5Atonic seizures (HP:0010819)4.11327472
6Epileptic encephalopathy (HP:0200134)3.65629916
7Action tremor (HP:0002345)3.49901215
8Papilledema (HP:0001085)3.39238015
9Absence seizures (HP:0002121)3.35908326
10Progressive cerebellar ataxia (HP:0002073)3.31322744
11Febrile seizures (HP:0002373)3.23847287
12Ankle clonus (HP:0011448)3.22381797
13Supranuclear gaze palsy (HP:0000605)3.20345670
14* Depression (HP:0000716)3.05036276
15Truncal ataxia (HP:0002078)2.99069883
16Generalized tonic-clonic seizures (HP:0002069)2.97876500
17Arterial tortuosity (HP:0005116)2.91660911
18Dialeptic seizures (HP:0011146)2.88496279
19Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.84036196
20Neurofibrillary tangles (HP:0002185)2.82156749
21Ventricular fibrillation (HP:0001663)2.69066971
22* Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.66358240
23Vascular tortuosity (HP:0004948)2.65555622
24Failure to thrive in infancy (HP:0001531)2.65363886
25* Pheochromocytoma (HP:0002666)2.60813388
26Poor eye contact (HP:0000817)2.60421445
27Hypoventilation (HP:0002791)2.58751241
28* Anxiety (HP:0000739)2.56569222
29Abnormal respiratory motile cilium morphology (HP:0005938)2.49117725
30Abnormal respiratory epithelium morphology (HP:0012253)2.49117725
31Bundle branch block (HP:0011710)2.47988803
32Rhinitis (HP:0012384)2.47090433
33Epileptiform EEG discharges (HP:0011182)2.46039923
34Dysmetric saccades (HP:0000641)2.45980328
35Limb dystonia (HP:0002451)2.44363538
36Hyporeflexia of lower limbs (HP:0002600)2.44217967
37EEG with generalized epileptiform discharges (HP:0011198)2.44044773
38Abnormal eating behavior (HP:0100738)2.42233568
39Impaired vibration sensation in the lower limbs (HP:0002166)2.41778665
40Impaired social interactions (HP:0000735)2.39696656
41Abnormal social behavior (HP:0012433)2.39696656
42Macroorchidism (HP:0000053)2.38491537
43Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.38454249
44Impaired smooth pursuit (HP:0007772)2.37910981
45Postural instability (HP:0002172)2.37023473
46Hypsarrhythmia (HP:0002521)2.35151625
47Urinary urgency (HP:0000012)2.34258375
48* Papillary thyroid carcinoma (HP:0002895)2.33852363
49Abnormal respiratory motile cilium physiology (HP:0012261)2.33203543
50Abnormal ciliary motility (HP:0012262)2.32219988
51Postural tremor (HP:0002174)2.30736949
52Genetic anticipation (HP:0003743)2.30390304
53Interstitial pulmonary disease (HP:0006530)2.29185555
54Resting tremor (HP:0002322)2.28882912
55Abnormality of the lower motor neuron (HP:0002366)2.28790841
56Urinary bladder sphincter dysfunction (HP:0002839)2.27913435
57Heterochromia iridis (HP:0001100)2.27697800
58Dysdiadochokinesis (HP:0002075)2.26662963
59Prolonged QT interval (HP:0001657)2.26630072
60Torticollis (HP:0000473)2.24210784
61* Neuroendocrine neoplasm (HP:0100634)2.23077486
62* Hypercortisolism (HP:0001578)2.22703365
63Amblyopia (HP:0000646)2.20662102
64Dynein arm defect of respiratory motile cilia (HP:0012255)2.19487084
65Absent/shortened dynein arms (HP:0200106)2.19487084
66Insidious onset (HP:0003587)2.17491749
67Termporal pattern (HP:0011008)2.17491749
68Broad-based gait (HP:0002136)2.15855081
69Absent frontal sinuses (HP:0002688)2.15254917
70Sudden death (HP:0001699)2.14972728
71Insomnia (HP:0100785)2.14312432
72Abnormal EKG (HP:0003115)2.13621050
73Gaze-evoked nystagmus (HP:0000640)2.12928273
74Cerebral aneurysm (HP:0004944)2.12903566
75Dysmetria (HP:0001310)2.11880151
76Hyperventilation (HP:0002883)2.10707172
77Bradykinesia (HP:0002067)2.09307758
78Impaired pain sensation (HP:0007328)2.06723868
79Abnormality of pain sensation (HP:0010832)2.06723868
80Hemiplegia (HP:0002301)2.04462047
81Focal dystonia (HP:0004373)2.03611912
82* Agitation (HP:0000713)2.02088966
83Mutism (HP:0002300)2.01333521
84Subaortic stenosis (HP:0001682)2.00489176
85Abnormality of the left ventricular outflow tract (HP:0011103)2.00489176
86Difficulty running (HP:0009046)2.00185074
87Abnormality of binocular vision (HP:0011514)2.00065828
88Diplopia (HP:0000651)2.00065828
89Abnormality of ocular smooth pursuit (HP:0000617)1.99903741
90Abnormality of the corticospinal tract (HP:0002492)1.99578082
91Megalencephaly (HP:0001355)1.99530471
92Asymmetric septal hypertrophy (HP:0001670)1.99125796
93Subacute progressive viral hepatitis (HP:0006572)1.98957447
94Atrioventricular block (HP:0001678)1.98760309
95Rapidly progressive (HP:0003678)1.98627790
96Muscle fiber splitting (HP:0003555)1.98591090
97Intention tremor (HP:0002080)1.98206806
98Progressive inability to walk (HP:0002505)1.98171500
99Asymmetry of the thorax (HP:0001555)1.95806717
100Tetraparesis (HP:0002273)1.94563858
101Scanning speech (HP:0002168)1.94112684
102Spastic gait (HP:0002064)1.93830643
103Pointed chin (HP:0000307)1.93786138
104Excessive salivation (HP:0003781)1.92218572
105Drooling (HP:0002307)1.92218572
106Hammertoe (HP:0001765)1.92098177
107Hand muscle atrophy (HP:0009130)1.92083410
108Skin nodule (HP:0200036)1.90683025
109Right ventricular cardiomyopathy (HP:0011663)1.89767184
110Myotonia (HP:0002486)1.88840525
111Hyperparathyroidism (HP:0000843)1.88239203
112Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.87760458
113Craniofacial dystonia (HP:0012179)1.87546945
114Hyperinsulinemic hypoglycemia (HP:0000825)1.87269591
115Fetal akinesia sequence (HP:0001989)1.85854694
116Stereotypic behavior (HP:0000733)1.85187874
117Gait ataxia (HP:0002066)1.85121549
118Abnormality of the common coagulation pathway (HP:0010990)1.84372379
119Lower limb muscle weakness (HP:0007340)1.83474716
120Syncope (HP:0001279)1.83460892
121Hemiparesis (HP:0001269)1.83380882
122* Abnormality of calcium-phosphate metabolism (HP:0100530)1.82821461
123Abnormality of the foot musculature (HP:0001436)1.80884311
124Decreased motor nerve conduction velocity (HP:0003431)1.80313211
125Degeneration of the lateral corticospinal tracts (HP:0002314)1.80296489
126Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.80296489
127Autoamputation (HP:0001218)1.79169929
128Exercise-induced myalgia (HP:0003738)1.78590233
129Foot dorsiflexor weakness (HP:0009027)1.78164320
130Cerebral inclusion bodies (HP:0100314)1.77137184
131Enlarged penis (HP:0000040)1.74859084
132Heart block (HP:0012722)1.74453948
133Protrusio acetabuli (HP:0003179)1.74363846
134Abnormal atrioventricular conduction (HP:0005150)1.74191465
135Rigidity (HP:0002063)1.73644842
136Limb-girdle muscle atrophy (HP:0003797)1.73058105
137Central scotoma (HP:0000603)1.72851876
138Amyotrophic lateral sclerosis (HP:0007354)1.72563903
139Upper limb amyotrophy (HP:0009129)1.72273222
140Distal upper limb amyotrophy (HP:0007149)1.72273222
141Abnormality of the calf musculature (HP:0001430)1.72053244
142Exercise-induced muscle cramps (HP:0003710)1.71354515
143Male infertility (HP:0003251)1.71031332
144Ventricular arrhythmia (HP:0004308)1.70485954
145Abnormality of the hip-girdle musculature (HP:0001445)1.69904797
146Abnormality of the musculature of the pelvis (HP:0001469)1.69904797
147Deep venous thrombosis (HP:0002625)1.69551089
148Clonus (HP:0002169)1.68881491
149Shoulder girdle muscle weakness (HP:0003547)1.68836621
150Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.68300320
151Atrial fibrillation (HP:0005110)1.67958449
152Distal lower limb amyotrophy (HP:0008944)1.67853585
153* Neoplasm of the peripheral nervous system (HP:0100007)1.67535370
154Distal lower limb muscle weakness (HP:0009053)1.67303347
155Primary atrial arrhythmia (HP:0001692)1.67049987
156Decreased circulating renin level (HP:0003351)1.66773394
157* Thyroid carcinoma (HP:0002890)1.66755056
158* Blue irides (HP:0000635)1.66316179
159Ventricular tachycardia (HP:0004756)1.65966194
160Mucopolysacchariduria (HP:0008155)1.65776887
161Urinary glycosaminoglycan excretion (HP:0003541)1.65776887
162Frequent falls (HP:0002359)1.65351061
163Hyperthyroidism (HP:0000836)1.64918750
164Ankyloglossia (HP:0010296)1.64886377
165Lower limb amyotrophy (HP:0007210)1.64286441
166Gingival bleeding (HP:0000225)1.62880494
167Orthostatic hypotension (HP:0001278)1.62420568
168Hypoplasia of the iris (HP:0007676)1.61119331
169Flat acetabular roof (HP:0003180)1.60464377
170Menorrhagia (HP:0000132)1.59902990
171EMG: myopathic abnormalities (HP:0003458)1.59899539
172Difficulty climbing stairs (HP:0003551)1.59504954
173Neuronal loss in central nervous system (HP:0002529)1.58253627
174Bronchiectasis (HP:0002110)1.56806861
175Aneurysm (HP:0002617)1.54602104

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.02105509
2MAP3K93.40737905
3MARK12.65081170
4MAP3K42.62492158
5MINK12.60762787
6BCR2.48230151
7PRKD32.44787035
8NTRK12.41308672
9KSR22.32809818
10MAP3K122.17075535
11EPHA42.15435462
12EPHB12.14132521
13PAK62.12681616
14FGFR32.08471866
15MAP2K72.07600217
16DAPK22.04116936
17CAMKK11.99266997
18FGFR41.94517184
19NEK91.88739042
20MAP3K21.84097142
21CAMKK21.76411676
22MAP3K61.72760326
23UHMK11.66920449
24NTRK21.66640986
25MAP2K41.64747278
26JAK11.60268759
27LMTK21.57961503
28PRKCH1.48296419
29RET1.46815759
30CDK51.46074408
31TRIB31.45046302
32SCYL21.43614386
33KSR11.42204519
34YES11.37049586
35TRIM281.32568164
36PAK31.32500678
37DAPK11.30296429
38CASK1.30286846
39PHKG11.27912462
40PHKG21.27912462
41CDK191.19541606
42MAP3K11.17511979
43PLK21.17198875
44WNK31.13425541
45ARAF1.11176961
46NEK61.08604753
47GRK51.07846536
48DYRK1B1.07604315
49STK381.03141019
50PDGFRA1.01995669
51SGK2231.01734690
52SGK4941.01734690
53STK38L0.99256067
54PRPF4B0.99223453
55TTN0.96227862
56NEK10.95724947
57INSRR0.95243395
58PRKCG0.94907340
59CDK140.94564437
60HIPK20.93600387
61PDGFRB0.93550107
62PIK3CA0.93266746
63LATS10.92507243
64CDC42BPA0.91636491
65RIPK10.89266840
66LIMK10.88299537
67SGK30.88265525
68MAPK130.87954076
69TAOK10.87655360
70CDK180.85424978
71MAP3K50.84752710
72SGK20.84150544
73ALK0.83030122
74FGR0.82470955
75FER0.82225397
76CDK150.81630577
77MYLK0.81145869
78WNK10.80500317
79SIK30.80462451
80WNK40.80409116
81ROCK20.79815377
82JAK20.77908978
83PKN20.77713878
84CAMK2A0.76928214
85CSK0.76891417
86PTK2B0.76524434
87SIK20.75129088
88TYRO30.70554323
89FES0.70110663
90CDK11A0.69826737
91FGFR20.69804506
92CAMK10.69521211
93CDK60.69080055
94TRPM70.68976858
95MAPK150.66153219
96BMPR20.65020159
97LATS20.64583034
98MAP2K10.64507079
99MAP3K130.63150091
100RPS6KA20.62876162
101PTK20.61026725
102CAMK2D0.59843140
103PDK10.59766040
104MAP3K140.59755740
105PINK10.59677645
106STK110.59484990
107PRKCE0.59471670
108CSNK1G20.59141268
109TESK10.57387556
110DMPK0.56953918
111MARK20.56526531
112PDPK10.55794173
113CAMK2B0.55755035
114MET0.55591668
115CSNK1A1L0.54985057
116TGFBR20.54774407
117MAPK70.53395853
118MAPK120.51591274
119BRD40.51226674
120RIPK40.49778477
121RAF10.49418026
122CAMK2G0.49047368
123ICK0.48836616
124IRAK10.48288322
125SGK10.48130099
126ERBB20.46348763
127RPS6KB10.45891330
128MAPK100.45816619
129ERBB30.45168165
130BRSK10.44624032
131MOS0.44009123
132FYN0.43056795
133DYRK1A0.42158331
134ROCK10.41799077
135PDK30.41314438
136PDK40.41314438
137EPHA30.40830643
138PRKD10.40761906
139RPS6KA30.40503103
140AKT30.39359718

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.19588107
2Nicotine addiction_Homo sapiens_hsa050332.40791699
3Insulin secretion_Homo sapiens_hsa049112.37790249
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.36721884
5Circadian entrainment_Homo sapiens_hsa047132.32762487
6GABAergic synapse_Homo sapiens_hsa047272.27944182
7Olfactory transduction_Homo sapiens_hsa047402.26095422
8Long-term potentiation_Homo sapiens_hsa047202.19504126
9Amphetamine addiction_Homo sapiens_hsa050312.14444325
10Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.07537862
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.04432068
12Morphine addiction_Homo sapiens_hsa050322.02746438
13Dopaminergic synapse_Homo sapiens_hsa047282.01808678
14Glutamatergic synapse_Homo sapiens_hsa047241.83124282
15Cholinergic synapse_Homo sapiens_hsa047251.75063851
16Cocaine addiction_Homo sapiens_hsa050301.72737387
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.71234254
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.69659345
19Gastric acid secretion_Homo sapiens_hsa049711.62238261
20Salivary secretion_Homo sapiens_hsa049701.61161730
21Type II diabetes mellitus_Homo sapiens_hsa049301.58669183
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.55659286
23Vibrio cholerae infection_Homo sapiens_hsa051101.54727740
24Taste transduction_Homo sapiens_hsa047421.53704047
25Renin secretion_Homo sapiens_hsa049241.51109768
26Collecting duct acid secretion_Homo sapiens_hsa049661.46511841
27Oxytocin signaling pathway_Homo sapiens_hsa049211.42095794
28Long-term depression_Homo sapiens_hsa047301.36245794
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.35463166
30Serotonergic synapse_Homo sapiens_hsa047261.35198507
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26327901
32Gap junction_Homo sapiens_hsa045401.25781183
33Estrogen signaling pathway_Homo sapiens_hsa049151.24846172
34GnRH signaling pathway_Homo sapiens_hsa049121.23929837
35Calcium signaling pathway_Homo sapiens_hsa040201.15081105
36Adherens junction_Homo sapiens_hsa045201.14292342
37cAMP signaling pathway_Homo sapiens_hsa040241.13849124
38Dilated cardiomyopathy_Homo sapiens_hsa054141.12968940
39Glioma_Homo sapiens_hsa052141.12186688
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09449761
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.08115615
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06051327
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03716761
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03468439
45Type I diabetes mellitus_Homo sapiens_hsa049401.02027040
46ECM-receptor interaction_Homo sapiens_hsa045120.98524080
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97494889
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.96592071
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95694362
50Neurotrophin signaling pathway_Homo sapiens_hsa047220.95371331
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.92609631
52Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90520439
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.89726142
54Dorso-ventral axis formation_Homo sapiens_hsa043200.89335083
55ErbB signaling pathway_Homo sapiens_hsa040120.88730183
56Complement and coagulation cascades_Homo sapiens_hsa046100.87586725
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87469501
58Cardiac muscle contraction_Homo sapiens_hsa042600.87020130
59Thyroid hormone synthesis_Homo sapiens_hsa049180.86740219
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.86724694
61Melanogenesis_Homo sapiens_hsa049160.86406062
62Amoebiasis_Homo sapiens_hsa051460.86043799
63Glucagon signaling pathway_Homo sapiens_hsa049220.83678720
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83628638
65Pancreatic secretion_Homo sapiens_hsa049720.81660447
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81555892
67Phagosome_Homo sapiens_hsa041450.81167441
68Proteoglycans in cancer_Homo sapiens_hsa052050.77477364
69Axon guidance_Homo sapiens_hsa043600.77403477
70Circadian rhythm_Homo sapiens_hsa047100.77267400
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.72817460
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.72767185
73AMPK signaling pathway_Homo sapiens_hsa041520.72740233
74Endocytosis_Homo sapiens_hsa041440.72444100
75Phenylalanine metabolism_Homo sapiens_hsa003600.72142444
76mTOR signaling pathway_Homo sapiens_hsa041500.71982095
77Tight junction_Homo sapiens_hsa045300.71849119
78Oocyte meiosis_Homo sapiens_hsa041140.71641497
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70820895
80Bile secretion_Homo sapiens_hsa049760.70706931
81Pancreatic cancer_Homo sapiens_hsa052120.69927430
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69841185
83Endometrial cancer_Homo sapiens_hsa052130.69315119
84MAPK signaling pathway_Homo sapiens_hsa040100.69168339
85* Insulin signaling pathway_Homo sapiens_hsa049100.68713919
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67605580
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67558253
88VEGF signaling pathway_Homo sapiens_hsa043700.67508384
89Histidine metabolism_Homo sapiens_hsa003400.66331713
90ABC transporters_Homo sapiens_hsa020100.65424764
91Prolactin signaling pathway_Homo sapiens_hsa049170.65214701
92Renal cell carcinoma_Homo sapiens_hsa052110.63883471
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63543983
94Fatty acid biosynthesis_Homo sapiens_hsa000610.63014889
95Prion diseases_Homo sapiens_hsa050200.61326003
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.60540030
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60395603
98FoxO signaling pathway_Homo sapiens_hsa040680.56854001
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56171495
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56019592
101Salmonella infection_Homo sapiens_hsa051320.56012348
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54253933
103Inositol phosphate metabolism_Homo sapiens_hsa005620.54114312
104Rap1 signaling pathway_Homo sapiens_hsa040150.53357458
105Ras signaling pathway_Homo sapiens_hsa040140.50803885
106Colorectal cancer_Homo sapiens_hsa052100.50572494
107Choline metabolism in cancer_Homo sapiens_hsa052310.49979389
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.49504417
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48756622
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48031814
111Non-small cell lung cancer_Homo sapiens_hsa052230.47909995
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47904850
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.45089736
114Chemokine signaling pathway_Homo sapiens_hsa040620.44772642
115Insulin resistance_Homo sapiens_hsa049310.40650972
116Lysosome_Homo sapiens_hsa041420.40437157
117Alcoholism_Homo sapiens_hsa050340.40129879
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38289815
119Platelet activation_Homo sapiens_hsa046110.36861267
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36812947
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36038038
122Focal adhesion_Homo sapiens_hsa045100.34983469
123Ovarian steroidogenesis_Homo sapiens_hsa049130.34236212
124Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33123466
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33040615

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