PRKAR2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.45145947
2L-phenylalanine catabolic process (GO:0006559)4.45145947
3triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.44526673
4L-phenylalanine metabolic process (GO:0006558)4.39668857
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.39668857
6negative regulation of fibrinolysis (GO:0051918)4.11468561
7actin-mediated cell contraction (GO:0070252)4.03394188
8alpha-linolenic acid metabolic process (GO:0036109)3.97950229
9fatty acid transmembrane transport (GO:1902001)3.95935578
10urea cycle (GO:0000050)3.94753532
11urea metabolic process (GO:0019627)3.94753532
12carnitine shuttle (GO:0006853)3.89156078
13cellular ketone body metabolic process (GO:0046950)3.88655859
14cysteine metabolic process (GO:0006534)3.88575197
15kynurenine metabolic process (GO:0070189)3.82971415
16lysine catabolic process (GO:0006554)3.82053469
17lysine metabolic process (GO:0006553)3.82053469
18pyrimidine nucleobase catabolic process (GO:0006208)3.80890973
19aromatic amino acid family catabolic process (GO:0009074)3.78430848
20plasma membrane repair (GO:0001778)3.75105779
21glyoxylate metabolic process (GO:0046487)3.68953095
22regulation of fibrinolysis (GO:0051917)3.67756675
23regulation of triglyceride catabolic process (GO:0010896)3.56559706
24regulation of protein activation cascade (GO:2000257)3.54682351
25nitrogen cycle metabolic process (GO:0071941)3.54049477
26sulfur amino acid catabolic process (GO:0000098)3.53615664
27nucleobase catabolic process (GO:0046113)3.52929803
28bile acid biosynthetic process (GO:0006699)3.46504957
29complement activation, alternative pathway (GO:0006957)3.45716432
30homocysteine metabolic process (GO:0050667)3.45356217
31negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.44411639
32positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.42782630
33high-density lipoprotein particle remodeling (GO:0034375)3.42129945
34dicarboxylic acid biosynthetic process (GO:0043650)3.40332863
35sarcomere organization (GO:0045214)3.40183227
36serine family amino acid catabolic process (GO:0009071)3.39825359
37protein carboxylation (GO:0018214)3.34294820
38peptidyl-glutamic acid carboxylation (GO:0017187)3.34294820
39regulation of complement activation (GO:0030449)3.33440221
40bundle of His cell to Purkinje myocyte communication (GO:0086069)3.33214539
41glutamate metabolic process (GO:0006536)3.31788353
42lymphangiogenesis (GO:0001946)3.30313343
43regulation of skeletal muscle contraction (GO:0014819)3.30100903
44ketone body metabolic process (GO:1902224)3.28958910
45negative regulation of cholesterol transport (GO:0032375)3.21506922
46negative regulation of sterol transport (GO:0032372)3.21506922
47fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.21250569
48triglyceride homeostasis (GO:0070328)3.18659908
49acylglycerol homeostasis (GO:0055090)3.18659908
50indole-containing compound catabolic process (GO:0042436)3.18377982
51indolalkylamine catabolic process (GO:0046218)3.18377982
52tryptophan catabolic process (GO:0006569)3.18377982
53regulation of cholesterol esterification (GO:0010872)3.17923653
54protein-lipid complex remodeling (GO:0034368)3.16736447
55macromolecular complex remodeling (GO:0034367)3.16736447
56plasma lipoprotein particle remodeling (GO:0034369)3.16736447
57bile acid and bile salt transport (GO:0015721)3.16097142
58behavioral response to nicotine (GO:0035095)3.14110544
59glucan catabolic process (GO:0009251)3.12534431
60positive regulation of fatty acid beta-oxidation (GO:0032000)3.12368586
61drug catabolic process (GO:0042737)3.11019605
62epoxygenase P450 pathway (GO:0019373)3.10615555
63cellular glucuronidation (GO:0052695)3.09507603
64acetyl-CoA metabolic process (GO:0006084)3.08570750
65positive regulation of lipid catabolic process (GO:0050996)3.07961491
66amino-acid betaine metabolic process (GO:0006577)3.07634452
67regulation of cholesterol homeostasis (GO:2000188)3.06431869
68glycogen catabolic process (GO:0005980)3.06409716
692-oxoglutarate metabolic process (GO:0006103)3.05655646
70bile acid metabolic process (GO:0008206)3.05480729
71plasma lipoprotein particle clearance (GO:0034381)3.04653757
72sarcoplasmic reticulum calcium ion transport (GO:0070296)3.03762282
73fibrinolysis (GO:0042730)3.00001378
74intestinal cholesterol absorption (GO:0030299)2.99953018
75response to muscle activity (GO:0014850)2.99316459
76carnitine transmembrane transport (GO:1902603)2.98826444
77reverse cholesterol transport (GO:0043691)2.98499146
78coenzyme catabolic process (GO:0009109)2.96670877
79aspartate family amino acid catabolic process (GO:0009068)2.95422596
80phospholipid efflux (GO:0033700)2.94653731
81alpha-amino acid catabolic process (GO:1901606)2.94432837
82tryptophan metabolic process (GO:0006568)2.93906058
83regulation of sequestering of triglyceride (GO:0010889)2.93478398
84amino-acid betaine transport (GO:0015838)2.92661035
85carnitine transport (GO:0015879)2.92661035
86paraxial mesoderm development (GO:0048339)2.92391897
87phospholipid homeostasis (GO:0055091)2.92042755
88cellular modified amino acid catabolic process (GO:0042219)2.88016010
89negative regulation of potassium ion transmembrane transport (GO:1901380)2.86692509
90cholesterol efflux (GO:0033344)2.85422416
91skeletal muscle contraction (GO:0003009)2.84122971
92cellular polysaccharide catabolic process (GO:0044247)2.82916535
93myofibril assembly (GO:0030239)2.81619697
94regulation of bile acid biosynthetic process (GO:0070857)2.80743533
95muscle filament sliding (GO:0030049)2.79727449
96actin-myosin filament sliding (GO:0033275)2.79727449
97response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.78588396
98sterol homeostasis (GO:0055092)2.76851043
99cholesterol homeostasis (GO:0042632)2.75454144
100cellular amino acid catabolic process (GO:0009063)2.74905867
101uronic acid metabolic process (GO:0006063)2.74704845
102glucuronate metabolic process (GO:0019585)2.74704845
103ventricular cardiac muscle cell action potential (GO:0086005)2.73998345
104aromatic amino acid family metabolic process (GO:0009072)2.73832485
105polysaccharide catabolic process (GO:0000272)2.73790326
106tyrosine metabolic process (GO:0006570)2.73703086
107intestinal absorption (GO:0050892)2.73668864
108actin filament-based movement (GO:0030048)2.73199843
109positive regulation of fatty acid oxidation (GO:0046321)2.70331584
110plasma lipoprotein particle assembly (GO:0034377)2.68296928
111alkaloid metabolic process (GO:0009820)2.67108995
112cell communication involved in cardiac conduction (GO:0086065)2.66631804
113short-chain fatty acid metabolic process (GO:0046459)2.66354101
114myoblast fusion (GO:0007520)2.62698216
115response to inactivity (GO:0014854)2.55758439
116regulation of relaxation of muscle (GO:1901077)2.54733486
117regulation of hippo signaling (GO:0035330)2.53300429
118regulation of hexokinase activity (GO:1903299)2.51490262
119regulation of glucokinase activity (GO:0033131)2.51490262
120cardiac myofibril assembly (GO:0055003)2.46510995
121dorsal/ventral axis specification (GO:0009950)2.45961765
122myotube cell development (GO:0014904)2.45951465
123skeletal muscle fiber development (GO:0048741)2.45939234
124mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.42501958
125artery development (GO:0060840)2.37809161
126protein K6-linked ubiquitination (GO:0085020)2.36955253
127striated muscle contraction (GO:0006941)2.34017246
128actomyosin structure organization (GO:0031032)2.30888738
129dopaminergic neuron differentiation (GO:0071542)2.30049678
130cardiac muscle cell development (GO:0055013)2.29514657
131cornea development in camera-type eye (GO:0061303)2.28053098
132ribonucleoprotein complex disassembly (GO:0032988)2.25583330
133cytoplasmic mRNA processing body assembly (GO:0033962)2.24913417
134regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.24468779
135adult heart development (GO:0007512)2.23425153
136interkinetic nuclear migration (GO:0022027)2.23209441
137positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.22921544
138mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.21489706
139muscle contraction (GO:0006936)2.19271928
140protein localization to microtubule (GO:0035372)2.18142908
141establishment of protein localization to mitochondrial membrane (GO:0090151)2.16870865
142kidney mesenchyme development (GO:0072074)2.15272065
143nuclear pore organization (GO:0006999)2.12945943
144organelle disassembly (GO:1903008)2.12710500
145protein localization to cytoskeleton (GO:0044380)2.11121875
146NLS-bearing protein import into nucleus (GO:0006607)2.10683050
147energy coupled proton transport, down electrochemical gradient (GO:0015985)2.08292223
148ATP synthesis coupled proton transport (GO:0015986)2.08292223
149hindbrain development (GO:0030902)2.08163808
150regulation of sarcomere organization (GO:0060297)2.07552442
151syncytium formation by plasma membrane fusion (GO:0000768)2.07433147
152muscle fiber development (GO:0048747)2.07267364
153protein localization to microtubule cytoskeleton (GO:0072698)2.07157347
154muscle cell fate commitment (GO:0042693)2.06538543
155signal transduction involved in regulation of gene expression (GO:0023019)2.05145175
156striated muscle cell development (GO:0055002)2.04362689
157cardiac cell development (GO:0055006)2.04193745
158otic vesicle formation (GO:0030916)2.03295877
159regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.01780866
160respiratory electron transport chain (GO:0022904)2.00311843
161muscle tissue morphogenesis (GO:0060415)2.00240660
162electron transport chain (GO:0022900)2.00175010
163cell migration involved in gastrulation (GO:0042074)1.99245132
164neuron fate specification (GO:0048665)1.98434674
165hippo signaling (GO:0035329)1.98237668
166regulation of secondary heart field cardioblast proliferation (GO:0003266)1.98009217
167regulation of cardioblast proliferation (GO:0003264)1.98009217
168glucan biosynthetic process (GO:0009250)1.97632397
169glycogen biosynthetic process (GO:0005978)1.97632397
170negative regulation of protein localization to cell surface (GO:2000009)1.97409596
171meiotic cell cycle (GO:0051321)1.96003845
172regulation of DNA endoreduplication (GO:0032875)1.95398902
173positive regulation of cardiac muscle cell differentiation (GO:2000727)1.95351302
174ventricular septum development (GO:0003281)1.94933168
175regulation of cell communication by electrical coupling (GO:0010649)1.94375677
176maturation of SSU-rRNA (GO:0030490)1.93925098
177skeletal muscle tissue development (GO:0007519)1.93464858
178cardiac muscle tissue morphogenesis (GO:0055008)1.93310899
179regulation of action potential (GO:0098900)1.92641495
180muscle system process (GO:0003012)1.92380607
181regulation of translational termination (GO:0006449)1.92303620
182embryonic foregut morphogenesis (GO:0048617)1.91659416
183regulation of meiosis I (GO:0060631)1.91281184
184regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)1.91241622
185notochord development (GO:0030903)1.89793868
186muscle structure development (GO:0061061)1.88255196
187neuron fate determination (GO:0048664)1.88068537
188positive regulation of sodium ion transmembrane transport (GO:1902307)1.87911336
189regulation of acyl-CoA biosynthetic process (GO:0050812)1.87663864

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.76478528
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.00043072
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.52513978
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.49164215
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.48184721
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.64982823
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.62369267
8ZNF263_19887448_ChIP-Seq_K562_Human2.59431461
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.44226628
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.37905462
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.31579699
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.25638284
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.25262229
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.18077026
15FUS_26573619_Chip-Seq_HEK293_Human2.11674728
16GBX2_23144817_ChIP-Seq_PC3_Human2.03389499
17CBX2_27304074_Chip-Seq_ESCs_Mouse1.93518161
18CLOCK_20551151_ChIP-Seq_293T_Human1.78880129
19TRIM28_21343339_ChIP-Seq_HEK293_Human1.77304258
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73610604
21* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69757625
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69734759
23ESR1_20079471_ChIP-ChIP_T-47D_Human1.69484182
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.68055558
25HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.67542735
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65874011
27EP300_21415370_ChIP-Seq_HL-1_Mouse1.64789435
28EWS_26573619_Chip-Seq_HEK293_Human1.63472560
29AR_21909140_ChIP-Seq_LNCAP_Human1.62066694
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57747324
31KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.55108502
32ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.54600560
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.53975400
34MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.52124963
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46137864
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.45209926
37* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44475050
38TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.41312512
39EZH2_22144423_ChIP-Seq_EOC_Human1.38050478
40FOXA2_19822575_ChIP-Seq_HepG2_Human1.37489556
41ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36555898
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36466533
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.36096027
44ZNF274_21170338_ChIP-Seq_K562_Hela1.34508846
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33983535
46CBP_20019798_ChIP-Seq_JUKART_Human1.33983535
47AHR_22903824_ChIP-Seq_MCF-7_Human1.30935172
48* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28737564
49ELK1_19687146_ChIP-ChIP_HELA_Human1.24473460
50* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.23899497
51IGF1R_20145208_ChIP-Seq_DFB_Human1.21814693
52PPAR_26484153_Chip-Seq_NCI-H1993_Human1.20903216
53NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19568966
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19226055
55* STAT3_23295773_ChIP-Seq_U87_Human1.15429740
56KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14357297
57RNF2_27304074_Chip-Seq_NSC_Mouse1.12841032
58P300_19829295_ChIP-Seq_ESCs_Human1.12776855
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.12432538
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11991797
61* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11855253
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10995068
63MYC_18940864_ChIP-ChIP_HL60_Human1.10941708
64KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.10700002
65* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10134121
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09779999
67NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09385902
68* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09349997
69RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08748001
70AR_21572438_ChIP-Seq_LNCaP_Human1.08588613
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08422531
72FOXO3_23340844_ChIP-Seq_DLD1_Human1.08374157
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.08177447
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07996368
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07996368
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07490981
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07229553
78FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.06784890
79EZH2_18974828_ChIP-Seq_MESCs_Mouse1.06644276
80RNF2_18974828_ChIP-Seq_MESCs_Mouse1.06644276
81BCAT_22108803_ChIP-Seq_LS180_Human1.06266481
82TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.06098426
83CJUN_26792858_Chip-Seq_BT549_Human1.05704717
84FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.05522072
85* TCF4_23295773_ChIP-Seq_U87_Human1.04432527
86ERG_21242973_ChIP-ChIP_JURKAT_Human1.04266108
87TCF4_18268006_ChIP-ChIP_LS174T_Human1.03188710
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02705383
89* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02416525
90RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02351413
91AR_25329375_ChIP-Seq_VCAP_Human1.02005728
92* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01527834
93TAF15_26573619_Chip-Seq_HEK293_Human1.01242527
94TBX20_22080862_ChIP-Seq_HEART_Mouse1.01205575
95TBX20_22328084_ChIP-Seq_HEART_Mouse1.01205575
96TBL1_22424771_ChIP-Seq_293T_Human1.01030354
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01026109
98PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99819534
99WT1_19549856_ChIP-ChIP_CCG9911_Human0.98873043
100GABP_17652178_ChIP-ChIP_JURKAT_Human0.98850118
101SMAD3_21741376_ChIP-Seq_EPCs_Human0.98785951
102FLI1_27457419_Chip-Seq_LIVER_Mouse0.98439345
103CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97961962
104CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97951931
105ER_23166858_ChIP-Seq_MCF-7_Human0.97813732
106MYC_18555785_ChIP-Seq_MESCs_Mouse0.96803954
107HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94720944
108SOX2_21211035_ChIP-Seq_LN229_Gbm0.94719632
109CDX2_22108803_ChIP-Seq_LS180_Human0.94365246
110* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.94252191
111PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94244319
112P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93361441
113SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92942134
114JUN_21703547_ChIP-Seq_K562_Human0.92818568
115SMAD4_21741376_ChIP-Seq_HESCs_Human0.92378911
116PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92289454
117TP53_16413492_ChIP-PET_HCT116_Human0.92045709
118EZH2_27294783_Chip-Seq_ESCs_Mouse0.91956267
119RBPJ_22232070_ChIP-Seq_NCS_Mouse0.91734424
120EZH2_27304074_Chip-Seq_ESCs_Mouse0.91620557
121* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.91270538
122TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90633668
123CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.90351713
124HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.90343610
125PIAS1_25552417_ChIP-Seq_VCAP_Human0.90068891
126ISL1_27105846_Chip-Seq_CPCs_Mouse0.89944795
127SOX2_20726797_ChIP-Seq_SW620_Human0.89398833
128SOX9_26525672_Chip-Seq_HEART_Mouse0.89097125
129TP53_18474530_ChIP-ChIP_U2OS_Human0.89071825
130ESR1_21235772_ChIP-Seq_MCF-7_Human0.88918361
131* HNF4A_19822575_ChIP-Seq_HepG2_Human0.88791271
132* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.88768365
133CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87904312
134NFYB_21822215_ChIP-Seq_K562_Human0.87812201
135ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87553930
136CDX2_20551321_ChIP-Seq_CACO-2_Human0.87330758
137* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.86642166
138KDM2B_26808549_Chip-Seq_K562_Human0.86050497
139PHF8_20622853_ChIP-Seq_HELA_Human0.85752124
140JARID2_20075857_ChIP-Seq_MESCs_Mouse0.85568103
141VDR_22108803_ChIP-Seq_LS180_Human0.85510867
142OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85401649
143AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84258914
144EZH2_27294783_Chip-Seq_NPCs_Mouse0.84136871
145CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83812511
146SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.83001873
147TOP2B_26459242_ChIP-Seq_MCF-7_Human0.82829523
148AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.82688458
149SOX9_24532713_ChIP-Seq_HFSC_Mouse0.82469953
150CREB1_15753290_ChIP-ChIP_HEK293T_Human0.82326014
151MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.82206300
152JARID2_20064375_ChIP-Seq_MESCs_Mouse0.81792519
153SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.81505912
154SALL4_18804426_ChIP-ChIP_XEN_Mouse0.81411190
155SMAD4_21741376_ChIP-Seq_EPCs_Human0.81409171
156TP63_23658742_ChIP-Seq_EP156T_Human0.81406610
157EED_16625203_ChIP-ChIP_MESCs_Mouse0.79695313
158KLF5_20875108_ChIP-Seq_MESCs_Mouse0.78960511
159SMAD4_21799915_ChIP-Seq_A2780_Human0.78525469
160GATA4_25053715_ChIP-Seq_YYC3_Human0.78420854
161ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.78287477
162SMAD3_21741376_ChIP-Seq_HESCs_Human0.78057829
163SALL1_21062744_ChIP-ChIP_HESCs_Human0.78044994
164CTCF_27219007_Chip-Seq_Bcells_Human0.77968497
165FOXM1_26456572_ChIP-Seq_MCF-7_Human0.77848780

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.73107493
2MP0005360_urolithiasis5.46996493
3MP0005085_abnormal_gallbladder_physiolo4.46977955
4MP0005365_abnormal_bile_salt3.62862412
5MP0008875_abnormal_xenobiotic_pharmacok3.13628529
6MP0003705_abnormal_hypodermis_morpholog2.82563831
7MP0003252_abnormal_bile_duct2.74507683
8MP0002837_dystrophic_cardiac_calcinosis2.73772435
9MP0005083_abnormal_biliary_tract2.65013986
10MP0000751_myopathy2.50140738
11MP0010329_abnormal_lipoprotein_level2.44560698
12MP0003806_abnormal_nucleotide_metabolis2.17913811
13MP0004130_abnormal_muscle_cell2.13247085
14MP0001666_abnormal_nutrient_absorption2.03430127
15MP0003950_abnormal_plasma_membrane2.01017180
16MP0003890_abnormal_embryonic-extraembry1.94804724
17MP0004145_abnormal_muscle_electrophysio1.93111950
18MP0006292_abnormal_olfactory_placode1.92377581
19MP0000749_muscle_degeneration1.81265585
20MP0003646_muscle_fatigue1.76581778
21MP0002160_abnormal_reproductive_system1.68865561
22MP0005332_abnormal_amino_acid1.68475069
23MP0004087_abnormal_muscle_fiber1.65251519
24MP0000566_synostosis1.63689967
25MP0003718_maternal_effect1.62330797
26MP0010030_abnormal_orbit_morphology1.59699169
27MP0000747_muscle_weakness1.57053952
28MP0004270_analgesia1.55069532
29MP0002269_muscular_atrophy1.53592481
30MP0009840_abnormal_foam_cell1.51872363
31MP0003937_abnormal_limbs/digits/tail_de1.51545293
32MP0002796_impaired_skin_barrier1.48845786
33MP0010234_abnormal_vibrissa_follicle1.48308035
34MP0005330_cardiomyopathy1.47351325
35MP0000013_abnormal_adipose_tissue1.43283745
36MP0004036_abnormal_muscle_relaxation1.42734133
37MP0002938_white_spotting1.41076215
38MP0002118_abnormal_lipid_homeostasis1.40904562
39MP0009053_abnormal_anal_canal1.40639989
40MP0005620_abnormal_muscle_contractility1.40043501
41MP0005451_abnormal_body_composition1.39142731
42MP0004084_abnormal_cardiac_muscle1.36799639
43MP0000579_abnormal_nail_morphology1.33045659
44MP0009250_abnormal_appendicular_skeleto1.30357194
45MP0004215_abnormal_myocardial_fiber1.29041208
46MP0003868_abnormal_feces_composition1.27162689
47MP0000759_abnormal_skeletal_muscle1.24094243
48MP0000762_abnormal_tongue_morphology1.22776090
49MP0005666_abnormal_adipose_tissue1.19660086
50MP0004185_abnormal_adipocyte_glucose1.14922423
51MP0000049_abnormal_middle_ear1.14661722
52MP0003283_abnormal_digestive_organ1.14544621
53MP0002972_abnormal_cardiac_muscle1.13617125
54MP0006276_abnormal_autonomic_nervous1.13270035
55MP0002106_abnormal_muscle_physiology1.12992232
56MP0009384_cardiac_valve_regurgitation1.12370228
57MP0004019_abnormal_vitamin_homeostasis1.11373512
58MP0000750_abnormal_muscle_regeneration1.10702324
59MP0005187_abnormal_penis_morphology1.10476850
60MP0004233_abnormal_muscle_weight1.09009126
61MP0000609_abnormal_liver_physiology1.08625444
62MP0002138_abnormal_hepatobiliary_system1.08287291
63MP0005319_abnormal_enzyme/_coenzyme1.06357896
64MP0003755_abnormal_palate_morphology1.05863608
65MP0003221_abnormal_cardiomyocyte_apopto1.04656181
66MP0005275_abnormal_skin_tensile1.04442081
67MP0002876_abnormal_thyroid_physiology1.03181206
68MP0008789_abnormal_olfactory_epithelium1.02251085
69MP0003119_abnormal_digestive_system0.98677716
70MP0002735_abnormal_chemical_nociception0.97928454
71MP0003137_abnormal_impulse_conducting0.97780845
72MP0005369_muscle_phenotype0.96467047
73MP0003329_amyloid_beta_deposits0.96441067
74MP0006138_congestive_heart_failure0.96241838
75MP0002697_abnormal_eye_size0.95770991
76MP0009780_abnormal_chondrocyte_physiolo0.95525941
77MP0001879_abnormal_lymphatic_vessel0.95524906
78MP0000537_abnormal_urethra_morphology0.95084013
79MP0002971_abnormal_brown_adipose0.94437741
80MP0003942_abnormal_urinary_system0.93930114
81MP0005248_abnormal_Harderian_gland0.93787198
82MP0010630_abnormal_cardiac_muscle0.93244390
83MP0003195_calcinosis0.92812420
84MP0004484_altered_response_of0.92527399
85MP0000534_abnormal_ureter_morphology0.92245306
86MP0001544_abnormal_cardiovascular_syste0.91352514
87MP0005385_cardiovascular_system_phenoty0.91352514
88MP0009379_abnormal_foot_pigmentation0.89345360
89MP0005670_abnormal_white_adipose0.88247945
90MP0003567_abnormal_fetal_cardiomyocyte0.87940495
91MP0005084_abnormal_gallbladder_morpholo0.87647188
92MP0005623_abnormal_meninges_morphology0.87537906
93MP0003136_yellow_coat_color0.87302655
94MP0002233_abnormal_nose_morphology0.86799013
95MP0001286_abnormal_eye_development0.86624784
96MP0000372_irregular_coat_pigmentation0.86458826
97MP0004134_abnormal_chest_morphology0.86338602
98MP0002084_abnormal_developmental_patter0.85500438
99MP0003011_delayed_dark_adaptation0.84909870
100MP0003385_abnormal_body_wall0.84888973
101MP0001188_hyperpigmentation0.84818354
102MP0001293_anophthalmia0.84391913
103MP0001661_extended_life_span0.84024836
104MP0004043_abnormal_pH_regulation0.83936006
105MP0003315_abnormal_perineum_morphology0.83695537
106MP0002877_abnormal_melanocyte_morpholog0.83333863
107MP0005257_abnormal_intraocular_pressure0.82771353
108MP0000631_abnormal_neuroendocrine_gland0.82439020
109MP0000428_abnormal_craniofacial_morphol0.82342245
110MP0008775_abnormal_heart_ventricle0.82123590
111MP0005584_abnormal_enzyme/coenzyme_acti0.82010365
112MP0004142_abnormal_muscle_tone0.81628991
113MP0009697_abnormal_copulation0.81404874
114MP0002009_preneoplasia0.81352584
115MP0003935_abnormal_craniofacial_develop0.80432100
116MP0004858_abnormal_nervous_system0.79998196
117MP0005389_reproductive_system_phenotype0.79024100
118MP0002102_abnormal_ear_morphology0.78322997
119MP0003693_abnormal_embryo_hatching0.76871351
120MP0004085_abnormal_heartbeat0.76294319
121MP0002234_abnormal_pharynx_morphology0.75191637
122MP0002177_abnormal_outer_ear0.74460923
123MP0005375_adipose_tissue_phenotype0.71859763
124MP0005197_abnormal_uvea_morphology0.71738149
125MP0001299_abnormal_eye_distance/0.71240774
126MP0000733_abnormal_muscle_development0.70914150
127MP0005408_hypopigmentation0.70791636
128MP0005334_abnormal_fat_pad0.69842643
129MP0000003_abnormal_adipose_tissue0.69330330
130MP0003959_abnormal_lean_body0.68911144
131MP0006036_abnormal_mitochondrial_physio0.68802272
132MP0003941_abnormal_skin_development0.68236264
133MP0002108_abnormal_muscle_morphology0.67969029
134MP0000604_amyloidosis0.67845521
135MP0000462_abnormal_digestive_system0.67691725
136MP0008961_abnormal_basal_metabolism0.67436482
137MP0000778_abnormal_nervous_system0.67336550
138MP0010368_abnormal_lymphatic_system0.66725909
139MP0006035_abnormal_mitochondrial_morpho0.66393441
140MP0002078_abnormal_glucose_homeostasis0.66223408
141MP0004272_abnormal_basement_membrane0.65674924
142MP0002733_abnormal_thermal_nociception0.64331112
143MP0003566_abnormal_cell_adhesion0.61997978
144MP0002734_abnormal_mechanical_nocicepti0.61214686
145MP0002332_abnormal_exercise_endurance0.59912866
146MP0002127_abnormal_cardiovascular_syste0.59151805
147MP0001968_abnormal_touch/_nociception0.58704137
148MP0005501_abnormal_skin_physiology0.55489203
149MP0000427_abnormal_hair_cycle0.55383065
150MP0000538_abnormal_urinary_bladder0.55352761
151MP0005448_abnormal_energy_balance0.55147796
152MP0000467_abnormal_esophagus_morphology0.54251041
153MP0000569_abnormal_digit_pigmentation0.53648341
154MP0003191_abnormal_cellular_cholesterol0.53189287

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.85290970
2Intrahepatic cholestasis (HP:0001406)4.20479740
3Hyporeflexia of lower limbs (HP:0002600)4.09753599
4Xanthomatosis (HP:0000991)4.03894803
5Hypobetalipoproteinemia (HP:0003563)3.93111060
6Exercise-induced myalgia (HP:0003738)3.90014221
7Exercise-induced muscle cramps (HP:0003710)3.80914973
8Muscle fiber inclusion bodies (HP:0100299)3.74446231
9Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.67673626
10Right ventricular cardiomyopathy (HP:0011663)3.65564607
11Abnormality of monocarboxylic acid metabolism (HP:0010996)3.63051464
12Hypolipoproteinemia (HP:0010981)3.44088636
13Epidermoid cyst (HP:0200040)3.39541314
14Hypoalphalipoproteinemia (HP:0003233)3.31616847
15Abnormality of aromatic amino acid family metabolism (HP:0004338)3.31269507
16Sudden death (HP:0001699)3.21620944
17Muscle hypertrophy of the lower extremities (HP:0008968)3.12020458
18Myoglobinuria (HP:0002913)3.11977062
19Hyperlipoproteinemia (HP:0010980)3.09936586
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.09129008
21Calf muscle hypertrophy (HP:0008981)3.07294913
22Increased connective tissue (HP:0009025)3.06253866
23Muscle fiber splitting (HP:0003555)3.03719444
24Complement deficiency (HP:0004431)2.98449678
25Nemaline bodies (HP:0003798)2.96005363
26Difficulty running (HP:0009046)2.93397982
27Abnormality of the Achilles tendon (HP:0005109)2.89386361
28Type 1 muscle fiber predominance (HP:0003803)2.83845954
29Ketosis (HP:0001946)2.81630409
30Subaortic stenosis (HP:0001682)2.76696873
31Abnormality of the left ventricular outflow tract (HP:0011103)2.76696873
32Prolonged partial thromboplastin time (HP:0003645)2.66399336
33Distal arthrogryposis (HP:0005684)2.65365184
34Hyperammonemia (HP:0001987)2.65052304
35Abnormality of glutamine family amino acid metabolism (HP:0010902)2.64785815
36Muscle stiffness (HP:0003552)2.64189890
37Ketoacidosis (HP:0001993)2.61812643
38Achilles tendon contracture (HP:0001771)2.59896210
39Hypoglycemic coma (HP:0001325)2.58762807
40Abnormality of the calf musculature (HP:0001430)2.57739526
41Absent phalangeal crease (HP:0006109)2.52061554
42EMG: myopathic abnormalities (HP:0003458)2.52019790
43Ventricular tachycardia (HP:0004756)2.51105940
44Difficulty climbing stairs (HP:0003551)2.46111611
45Abnormality of the common coagulation pathway (HP:0010990)2.43836656
46Hyperglycinuria (HP:0003108)2.43743884
47Calcaneovalgus deformity (HP:0001848)2.41215601
48Abnormal gallbladder physiology (HP:0012438)2.40938198
49Cholecystitis (HP:0001082)2.40938198
50Neck muscle weakness (HP:0000467)2.38657430
51Abnormality of glycine metabolism (HP:0010895)2.37103232
52Abnormality of serine family amino acid metabolism (HP:0010894)2.37103232
53Myopathic facies (HP:0002058)2.36050153
54Myotonia (HP:0002486)2.34615720
55Termporal pattern (HP:0011008)2.33685633
56Insidious onset (HP:0003587)2.33685633
57Skin nodule (HP:0200036)2.32996816
58Hypercholesterolemia (HP:0003124)2.31138606
59Rhabdomyolysis (HP:0003201)2.30390600
60Hyperglycinemia (HP:0002154)2.30022617
61Cholelithiasis (HP:0001081)2.28408853
62Malnutrition (HP:0004395)2.23912722
63Fat malabsorption (HP:0002630)2.22687392
64Deformed tarsal bones (HP:0008119)2.22673923
65Frequent falls (HP:0002359)2.22007557
66Ulnar deviation of the wrist (HP:0003049)2.19909258
67Abnormality of complement system (HP:0005339)2.18851869
68Round ear (HP:0100830)2.18813653
69Hip contracture (HP:0003273)2.18807438
70Gout (HP:0001997)2.18538746
71Areflexia of lower limbs (HP:0002522)2.10593130
72Abnormal gallbladder morphology (HP:0012437)2.09788650
73Concave nail (HP:0001598)2.07003518
74Neonatal onset (HP:0003623)2.06127016
75Abnormal finger flexion creases (HP:0006143)2.04095305
76Abnormality of sulfur amino acid metabolism (HP:0004339)2.00051256
77Abnormality of aspartate family amino acid metabolism (HP:0010899)1.99420024
78Conjunctival hamartoma (HP:0100780)1.99257457
79Rimmed vacuoles (HP:0003805)1.98872320
80Back pain (HP:0003418)1.98662373
81Decreased subcutaneous fat (HP:0001002)1.98302593
82Ventricular fibrillation (HP:0001663)1.98132015
83Palpitations (HP:0001962)1.96994943
84Bundle branch block (HP:0011710)1.96875172
85Syncope (HP:0001279)1.96643204
86Type II lissencephaly (HP:0007260)1.94857657
87Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93974134
88Abnormality of alanine metabolism (HP:0010916)1.93974134
89Hyperalaninemia (HP:0003348)1.93974134
90Abnormality of the renal cortex (HP:0011035)1.89663320
91Hyperglycemia (HP:0003074)1.89458873
92Limited hip movement (HP:0008800)1.88460172
93Shoulder girdle muscle weakness (HP:0003547)1.88363446
94Ventricular arrhythmia (HP:0004308)1.88234105
95Asymmetric septal hypertrophy (HP:0001670)1.87372333
96Centrally nucleated skeletal muscle fibers (HP:0003687)1.86747614
97Abnormality of purine metabolism (HP:0004352)1.83997183
98EMG: neuropathic changes (HP:0003445)1.82465569
99Abnormality of the lower motor neuron (HP:0002366)1.81485356
100Spinal rigidity (HP:0003306)1.79890983
101Ileus (HP:0002595)1.76928103
102Delayed gross motor development (HP:0002194)1.76597587
103Fibular aplasia (HP:0002990)1.76364703
104Myocardial infarction (HP:0001658)1.76341609
105Hamartoma of the eye (HP:0010568)1.76012298
106Increased variability in muscle fiber diameter (HP:0003557)1.75336412
107Renal cortical cysts (HP:0000803)1.74446386
108Scapular winging (HP:0003691)1.73787489
109Hyperuricemia (HP:0002149)1.73421151
110Increased purine levels (HP:0004368)1.73421151
111Pheochromocytoma (HP:0002666)1.72716444
112Abnormality of fatty-acid metabolism (HP:0004359)1.72087360
113Hepatocellular carcinoma (HP:0001402)1.72041216
114Ulnar deviation of finger (HP:0009465)1.69694284
115Muscular dystrophy (HP:0003560)1.69628185
116Abnormality of the shoulder girdle musculature (HP:0001435)1.69394126
117Limb-girdle muscle atrophy (HP:0003797)1.68630072
118Distal lower limb muscle weakness (HP:0009053)1.66416579
119Abnormality of the musculature of the pelvis (HP:0001469)1.65954563
120Abnormality of the hip-girdle musculature (HP:0001445)1.65954563
121Symphalangism affecting the phalanges of the hand (HP:0009773)1.65009633
122Late onset (HP:0003584)1.64470761
123Abnormality of the intrinsic pathway (HP:0010989)1.64052190
124Lipoatrophy (HP:0100578)1.63974381
125Generalized muscle weakness (HP:0003324)1.62822185
126Mildly elevated creatine phosphokinase (HP:0008180)1.62380871
127Central scotoma (HP:0000603)1.61595907
128Proximal tubulopathy (HP:0000114)1.59613327
129Hyperkalemia (HP:0002153)1.57066539
130Fetal akinesia sequence (HP:0001989)1.56533055
131Gowers sign (HP:0003391)1.55847508
132Pancreatic cysts (HP:0001737)1.55401744
133Aplasia/Hypoplasia of the fovea (HP:0008060)1.54435665
134Hypoplasia of the fovea (HP:0007750)1.54435665
135Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.52766798
136Unilateral renal agenesis (HP:0000122)1.51391751
137Fatigable weakness (HP:0003473)1.49227352
138Abnormality of the neuromuscular junction (HP:0003398)1.49227352
139Cerebellar dysplasia (HP:0007033)1.48342990
140Congenital, generalized hypertrichosis (HP:0004540)1.46757577
141Coronal craniosynostosis (HP:0004440)1.43855519
142Congenital sensorineural hearing impairment (HP:0008527)1.43334244
143Chorioretinal atrophy (HP:0000533)1.43184093
144Aplasia of the musculature (HP:0100854)1.42564059
145Pachygyria (HP:0001302)1.42054354
146Molar tooth sign on MRI (HP:0002419)1.39663205
147Abnormality of midbrain morphology (HP:0002418)1.39663205
148Abnormality of the calcaneus (HP:0008364)1.39537930
149Tubular atrophy (HP:0000092)1.39494741
150Pancreatic fibrosis (HP:0100732)1.39017843
151Knee flexion contracture (HP:0006380)1.38215005
152Aplasia/Hypoplasia involving the musculature (HP:0001460)1.35412109
153Aplasia/Hypoplasia of the tibia (HP:0005772)1.35115040
154Abnormality of skeletal muscle fiber size (HP:0012084)1.34520228
155Metatarsus adductus (HP:0001840)1.34148184
156Nephronophthisis (HP:0000090)1.33291050
157Abnormality of subcutaneous fat tissue (HP:0001001)1.32319280
158Abnormal biliary tract morphology (HP:0012440)1.32275514
159Acute encephalopathy (HP:0006846)1.32222164
160Acute necrotizing encephalopathy (HP:0006965)1.31752972
161Abnormality of the pons (HP:0007361)1.31057861
162Limb-girdle muscle weakness (HP:0003325)1.30362657
163Progressive muscle weakness (HP:0003323)1.28867853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN3.22545266
2NEK13.10175538
3PHKG12.98766762
4PHKG22.98766762
5PNCK2.92443558
6LATS22.91305020
7PDK42.69060591
8PDK32.69060591
9MARK12.60695018
10TRIB32.58634485
11LMTK22.48185226
12OBSCN2.43029776
13LATS12.40380728
14MAP2K42.20890091
15PINK12.08550514
16PKN22.00648107
17EEF2K1.99516257
18WNK31.68628881
19EPHB21.64867279
20MAP3K91.58894553
21PAK31.58311398
22DMPK1.57067877
23FRK1.56855261
24PTK61.47774861
25ERBB41.45760047
26TLK11.40739010
27KSR21.37556838
28PDK21.33169877
29TSSK61.27981405
30BCKDK1.27108451
31TTK1.26209081
32MINK11.24233371
33LIMK11.24066730
34SIK11.23473547
35MST1R1.22052954
36CAMK1G1.21149384
37MAP3K21.19973490
38FER1.19081870
39RIPK11.18357963
40NTRK11.16326333
41PAK61.14037878
42MAP3K41.13216851
43RET1.13101496
44TNIK1.13002727
45STK31.07166407
46TRPM71.06528451
47PDGFRA1.06395108
48PIK3CA1.05400811
49BMPR1B1.04778343
50NME11.04092398
51MAPKAPK31.02533489
52TAOK11.02040760
53NEK21.01124581
54MAP2K11.00933928
55PIK3CG0.99508499
56MUSK0.98106733
57PBK0.96224947
58CCNB10.95869318
59STK38L0.95199859
60MAP3K70.94266840
61DDR20.93530703
62NEK90.93322650
63CHEK20.92509636
64GRK10.90393518
65WEE10.89109871
66ABL20.86287290
67STK160.85629870
68MAP3K50.83608213
69PRKAA10.82182181
70FGFR40.81876932
71MOS0.81687980
72ERBB30.81520329
73PTK20.79593154
74BMX0.78067801
75MAPK130.77627856
76MAP2K60.77190878
77TESK10.76411736
78ROCK10.76348766
79WNK40.76006883
80ICK0.74472183
81STK380.74434317
82MYLK0.72607094
83MAP3K60.71981151
84CDC70.71035392
85MAP2K30.70869234
86EPHA20.70851099
87PRKAA20.70443292
88PAK20.69993200
89MAPKAPK50.69602893
90BUB10.69014339
91ERBB20.68872302
92AKT30.68683518
93STK390.68645575
94MAP3K30.68588730
95EIF2AK30.66647468
96BRSK20.65290501
97MAPK120.63852350
98OXSR10.63825229
99KSR10.60909606
100STK110.60840023
101MAP3K110.58340702
102PRKCI0.57172065
103CAMK1D0.56880447
104CDK80.56816017
105SRPK10.56091839
106PLK10.55537406
107BRAF0.55340857
108CSNK1G20.53419127
109CDK90.52517384
110SCYL20.51995655
111NTRK30.51073937
112DYRK20.51039185
113CDK140.50280545
114AURKA0.49028704
115CAMK2D0.48619847
116TIE10.47282678
117CAMK2A0.47223860
118CAMKK10.47173167
119GRK50.46176709
120TGFBR10.46160349
121PTK2B0.45780206
122MET0.44925741
123FGFR10.44635392
124MTOR0.44430635
125TAF10.44192906
126ILK0.44011892
127AURKB0.43566956
128FGFR20.43322386
129* CSNK1E0.43253286
130STK240.43132567
131PRKACB0.42933101
132PLK30.42895555
133ZAK0.42797669
134DAPK20.42660712
135EPHA30.41868373
136CDK60.41810516
137CDK120.40568068
138MAPK40.40388304
139CAMK2G0.40090737
140RPS6KA20.40051152
141PRKD10.40012674
142ALK0.39930510
143NTRK20.39782696
144* PRKACG0.39763823
145MAPK150.39421936
146AKT20.39050993
147PDPK10.38552082
148PRKG10.38521682
149CASK0.38383198
150TYRO30.38247484
151PRKCG0.37896469
152* GSK3A0.37771886
153WNK10.37118019
154ADRBK10.36138258
155CHEK10.35628680

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.37267976
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.35683661
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.99399637
4Arginine biosynthesis_Homo sapiens_hsa002202.75025384
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.56922868
6Fatty acid degradation_Homo sapiens_hsa000712.41844146
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.27197098
8Butanoate metabolism_Homo sapiens_hsa006502.26374453
9Tryptophan metabolism_Homo sapiens_hsa003802.21116178
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.03869443
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.03839325
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.00724599
13Oxidative phosphorylation_Homo sapiens_hsa001901.96935913
14Propanoate metabolism_Homo sapiens_hsa006401.96739189
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90124252
16Fatty acid metabolism_Homo sapiens_hsa012121.85763899
17Complement and coagulation cascades_Homo sapiens_hsa046101.83965636
18PPAR signaling pathway_Homo sapiens_hsa033201.83056948
19Parkinsons disease_Homo sapiens_hsa050121.82451658
20Bile secretion_Homo sapiens_hsa049761.81879380
21Fat digestion and absorption_Homo sapiens_hsa049751.66702643
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.63015474
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.58323308
24Starch and sucrose metabolism_Homo sapiens_hsa005001.56996436
25Huntingtons disease_Homo sapiens_hsa050161.53350561
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.53042220
27Pyruvate metabolism_Homo sapiens_hsa006201.49116484
28Basal transcription factors_Homo sapiens_hsa030221.48007811
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.47941760
30Phenylalanine metabolism_Homo sapiens_hsa003601.46643282
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46497691
32Alzheimers disease_Homo sapiens_hsa050101.46362648
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.45426206
34Histidine metabolism_Homo sapiens_hsa003401.44637324
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43221107
36Carbon metabolism_Homo sapiens_hsa012001.42576265
37Ribosome_Homo sapiens_hsa030101.41966468
38beta-Alanine metabolism_Homo sapiens_hsa004101.36817699
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.28491319
40Chemical carcinogenesis_Homo sapiens_hsa052041.26857547
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.22741757
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17334837
43Peroxisome_Homo sapiens_hsa041461.16638375
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.14548803
45Protein export_Homo sapiens_hsa030601.14021989
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13277322
47RNA transport_Homo sapiens_hsa030131.12043785
48Tyrosine metabolism_Homo sapiens_hsa003501.08692667
49Retinol metabolism_Homo sapiens_hsa008301.08207394
50Caffeine metabolism_Homo sapiens_hsa002321.08159242
51Phototransduction_Homo sapiens_hsa047441.07529812
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.06641691
53Hippo signaling pathway_Homo sapiens_hsa043901.06483814
54RNA polymerase_Homo sapiens_hsa030201.06402091
55Circadian rhythm_Homo sapiens_hsa047101.06207150
56RNA degradation_Homo sapiens_hsa030181.04696266
57Steroid hormone biosynthesis_Homo sapiens_hsa001401.04692221
58Biosynthesis of amino acids_Homo sapiens_hsa012301.03646755
59Steroid biosynthesis_Homo sapiens_hsa001001.03405795
60Sulfur metabolism_Homo sapiens_hsa009200.98862469
61Fatty acid elongation_Homo sapiens_hsa000620.98148671
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97951608
63Fatty acid biosynthesis_Homo sapiens_hsa000610.97734486
64Nucleotide excision repair_Homo sapiens_hsa034200.94547205
65Arginine and proline metabolism_Homo sapiens_hsa003300.90891919
66Sulfur relay system_Homo sapiens_hsa041220.90850424
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.89778484
68Cardiac muscle contraction_Homo sapiens_hsa042600.89059113
69TGF-beta signaling pathway_Homo sapiens_hsa043500.88962542
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85849097
71Dilated cardiomyopathy_Homo sapiens_hsa054140.85618006
72One carbon pool by folate_Homo sapiens_hsa006700.84902372
73Glucagon signaling pathway_Homo sapiens_hsa049220.83648118
74Basal cell carcinoma_Homo sapiens_hsa052170.81653547
75Lysine degradation_Homo sapiens_hsa003100.78335222
76Hedgehog signaling pathway_Homo sapiens_hsa043400.77245863
77ABC transporters_Homo sapiens_hsa020100.77120147
78Selenocompound metabolism_Homo sapiens_hsa004500.76200725
79Linoleic acid metabolism_Homo sapiens_hsa005910.75150147
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72110521
81Glycerolipid metabolism_Homo sapiens_hsa005610.71043223
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.70711485
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70524648
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69937136
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68646585
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.68632638
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.68595244
88Insulin resistance_Homo sapiens_hsa049310.67767747
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65965420
90* Insulin signaling pathway_Homo sapiens_hsa049100.65923778
91Homologous recombination_Homo sapiens_hsa034400.65599302
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64328551
93AMPK signaling pathway_Homo sapiens_hsa041520.63523066
94Tight junction_Homo sapiens_hsa045300.60363986
95Metabolic pathways_Homo sapiens_hsa011000.57868589
96ECM-receptor interaction_Homo sapiens_hsa045120.57823208
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.57587522
98Fanconi anemia pathway_Homo sapiens_hsa034600.57348982
99Purine metabolism_Homo sapiens_hsa002300.56997194
100Staphylococcus aureus infection_Homo sapiens_hsa051500.56423441
101Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56295440
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55167379
103Cell cycle_Homo sapiens_hsa041100.54758658
104Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54622616
105Pyrimidine metabolism_Homo sapiens_hsa002400.54188573
106Ovarian steroidogenesis_Homo sapiens_hsa049130.52433971
107Folate biosynthesis_Homo sapiens_hsa007900.49878214
108Melanoma_Homo sapiens_hsa052180.48305912
109Glutathione metabolism_Homo sapiens_hsa004800.46860317
110Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44219328
111Adherens junction_Homo sapiens_hsa045200.43641611
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.41736560
113Dorso-ventral axis formation_Homo sapiens_hsa043200.39596120
114Vitamin digestion and absorption_Homo sapiens_hsa049770.38368608
115Galactose metabolism_Homo sapiens_hsa000520.37290450
116Prion diseases_Homo sapiens_hsa050200.36817693
117GnRH signaling pathway_Homo sapiens_hsa049120.36339671
118Maturity onset diabetes of the young_Homo sapiens_hsa049500.35164541
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33990206
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33678209
121Mineral absorption_Homo sapiens_hsa049780.32621754
122Vitamin B6 metabolism_Homo sapiens_hsa007500.32131753
123Viral myocarditis_Homo sapiens_hsa054160.31259583
124Axon guidance_Homo sapiens_hsa043600.30957121
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30925985
126Renin secretion_Homo sapiens_hsa049240.30624033
127Amoebiasis_Homo sapiens_hsa051460.29953643
128Fructose and mannose metabolism_Homo sapiens_hsa000510.29341767
129Focal adhesion_Homo sapiens_hsa045100.28683941
130Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27020855
131alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25623380
132Bladder cancer_Homo sapiens_hsa052190.24379278
133Gastric acid secretion_Homo sapiens_hsa049710.24230450
134Oxytocin signaling pathway_Homo sapiens_hsa049210.24219889
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24164694
136Gap junction_Homo sapiens_hsa045400.23653962
137Estrogen signaling pathway_Homo sapiens_hsa049150.22825781
138Type II diabetes mellitus_Homo sapiens_hsa049300.22275531
139Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.22096100

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