PRKAR2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline transport (GO:0015824)5.88560294
2regulation of sequestering of triglyceride (GO:0010889)5.74017342
3triglyceride catabolic process (GO:0019433)5.36734602
4white fat cell differentiation (GO:0050872)5.28778822
5low-density lipoprotein particle clearance (GO:0034383)5.15088921
6regulation of platelet aggregation (GO:0090330)5.11338824
7regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)5.05945232
8thrombin receptor signaling pathway (GO:0070493)5.02229051
9carnitine shuttle (GO:0006853)4.94397914
10negative regulation of norepinephrine secretion (GO:0010700)4.90378757
11neutral lipid catabolic process (GO:0046461)4.86362075
12acylglycerol catabolic process (GO:0046464)4.86362075
13fatty acid transmembrane transport (GO:1902001)4.67595594
14brown fat cell differentiation (GO:0050873)4.65238377
15nerve growth factor signaling pathway (GO:0038180)4.55953838
16* regulation of cAMP-dependent protein kinase activity (GO:2000479)4.52485588
17negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.45322936
18negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)4.40627882
19pyrimidine nucleobase catabolic process (GO:0006208)4.37668654
20negative regulation of homotypic cell-cell adhesion (GO:0034111)4.33000268
21adenosine receptor signaling pathway (GO:0001973)4.32118249
22layer formation in cerebral cortex (GO:0021819)4.28470897
23negative regulation of erythrocyte differentiation (GO:0045647)4.17293714
24nucleobase catabolic process (GO:0046113)4.17046085
25glycine transport (GO:0015816)4.08851685
26regulation of platelet activation (GO:0010543)4.08510148
27negative regulation of appetite (GO:0032099)4.06434834
28negative regulation of response to food (GO:0032096)4.06434834
29regulation of glycogen (starch) synthase activity (GO:2000465)4.06368753
30protein neddylation (GO:0045116)4.05395267
31alanine transport (GO:0032328)4.04191628
32lipid particle organization (GO:0034389)3.96640748
33neutrophil activation involved in immune response (GO:0002283)3.95034297
34regulation of lipoprotein metabolic process (GO:0050746)3.92361165
35regulation of fatty acid oxidation (GO:0046320)3.90611787
36regulation of gonadotropin secretion (GO:0032276)3.84323637
37regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.84299743
38NADH metabolic process (GO:0006734)3.76899448
39regulation of synapse structural plasticity (GO:0051823)3.76470297
40biotin metabolic process (GO:0006768)3.75752934
41tricarboxylic acid cycle (GO:0006099)3.74857798
42blood coagulation, intrinsic pathway (GO:0007597)3.74729948
43angiogenesis involved in wound healing (GO:0060055)3.73255070
44regulation of acyl-CoA biosynthetic process (GO:0050812)3.73126103
45carnitine transmembrane transport (GO:1902603)3.70375594
46positive regulation of fatty acid oxidation (GO:0046321)3.67842332
47regulation of short-term neuronal synaptic plasticity (GO:0048172)3.66761780
48negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.65419640
49synaptic vesicle maturation (GO:0016188)3.64771619
50negative regulation of heart rate (GO:0010459)3.63818999
51succinate metabolic process (GO:0006105)3.63609087
52platelet aggregation (GO:0070527)3.63048589
53glycerolipid catabolic process (GO:0046503)3.56954893
54coenzyme A biosynthetic process (GO:0015937)3.52644583
55vocalization behavior (GO:0071625)3.52620822
56triglyceride biosynthetic process (GO:0019432)3.52159692
57regulation of cofactor metabolic process (GO:0051193)3.51647429
58regulation of coenzyme metabolic process (GO:0051196)3.51647429
59cellular response to epinephrine stimulus (GO:0071872)3.48038812
60megakaryocyte development (GO:0035855)3.45624984
61negative regulation of platelet activation (GO:0010544)3.44428854
62positive regulation of endothelial cell differentiation (GO:0045603)3.44216513
63positive regulation of male gonad development (GO:2000020)3.42686063
64regulation of macrophage derived foam cell differentiation (GO:0010743)3.41324087
65negative regulation of catecholamine secretion (GO:0033604)3.38358940
66negative regulation of neurotransmitter transport (GO:0051589)3.37954930
67positive regulation of fatty acid beta-oxidation (GO:0032000)3.37421757
68positive regulation of glucose import (GO:0046326)3.36506429
69positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.33871814
70response to dietary excess (GO:0002021)3.32786331
71triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.29767748
72locomotory exploration behavior (GO:0035641)3.28454767
73regulation of integrin-mediated signaling pathway (GO:2001044)3.27804442
74phagocytosis, recognition (GO:0006910)3.27404046
75valine metabolic process (GO:0006573)3.26460428
76* activation of protein kinase A activity (GO:0034199)3.25626943
77acylglycerol biosynthetic process (GO:0046463)3.24500710
78neutral lipid biosynthetic process (GO:0046460)3.24500710
79neuron cell-cell adhesion (GO:0007158)3.23781840
80protoporphyrinogen IX metabolic process (GO:0046501)3.23397049
81amino-acid betaine transport (GO:0015838)3.22563846
82carnitine transport (GO:0015879)3.22563846
83negative regulation of phagocytosis (GO:0050765)3.21499583
84prepulse inhibition (GO:0060134)3.21495554
85definitive hemopoiesis (GO:0060216)3.19983273
86lipid storage (GO:0019915)3.16847089
87regulation of cholesterol storage (GO:0010885)3.16206501
88dopamine receptor signaling pathway (GO:0007212)3.15541782
89positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.14152240
90adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.13640500
91negative regulation of heart contraction (GO:0045822)3.13079846
92regulation of protein kinase A signaling (GO:0010738)3.12689600
93positive regulation of synaptic transmission, GABAergic (GO:0032230)3.12343210
94intracellular lipid transport (GO:0032365)3.10988186
95platelet formation (GO:0030220)3.10456992
96fatty acid elongation (GO:0030497)3.09529135
97fatty-acyl-CoA metabolic process (GO:0035337)3.09273863
98exploration behavior (GO:0035640)3.07570185
99positive regulation of receptor recycling (GO:0001921)3.06692667
100regulation of synaptic vesicle transport (GO:1902803)3.06657387
101positive regulation of cellular response to insulin stimulus (GO:1900078)3.06054885
102positive regulation of insulin receptor signaling pathway (GO:0046628)3.05180109
103positive regulation of mast cell activation (GO:0033005)3.04664495
104response to epinephrine (GO:0071871)3.03280228
105dendritic spine morphogenesis (GO:0060997)3.02877487
106negative regulation of amino acid transport (GO:0051956)3.02573667
107linoleic acid metabolic process (GO:0043651)3.00598860
108negative regulation of adherens junction organization (GO:1903392)2.99160248
109negative regulation of focal adhesion assembly (GO:0051895)2.99160248
110negative regulation of cell junction assembly (GO:1901889)2.99160248
111positive regulation of muscle hypertrophy (GO:0014742)2.99041996
112positive regulation of cardiac muscle hypertrophy (GO:0010613)2.99041996
113negative regulation of neurotransmitter secretion (GO:0046929)2.97986739
114positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.97320640
115positive regulation of cAMP-mediated signaling (GO:0043950)2.97254322
116regulation of female receptivity (GO:0045924)2.97173628
117synaptic vesicle exocytosis (GO:0016079)2.97054710
118positive regulation of glucose transport (GO:0010828)2.96224340
119regulation of glutamate receptor signaling pathway (GO:1900449)2.96192711
120negative regulation of blood circulation (GO:1903523)2.95177619
121regulation of synaptic vesicle exocytosis (GO:2000300)2.94354127
122regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.93078617
123clathrin coat assembly (GO:0048268)2.92737305
124regulation of fatty acid beta-oxidation (GO:0031998)2.92231581
125response to leptin (GO:0044321)2.91657252
126protein localization to synapse (GO:0035418)2.91548815
127regulation of inositol phosphate biosynthetic process (GO:0010919)2.90447896
128negative regulation of amine transport (GO:0051953)2.90188181
129positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.88472396
130cellular response to monoamine stimulus (GO:0071868)2.86662878
131cellular response to catecholamine stimulus (GO:0071870)2.86662878
132CDP-diacylglycerol biosynthetic process (GO:0016024)2.84689653
133mating behavior (GO:0007617)2.83972738
134negative regulation of macrophage differentiation (GO:0045650)2.83054979
135regulation of Golgi to plasma membrane protein transport (GO:0042996)2.82715029
136myeloid cell development (GO:0061515)2.82253056
137regulation of homotypic cell-cell adhesion (GO:0034110)2.81199352
138regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.80690050
139striatum development (GO:0021756)2.80616660
140response to nerve growth factor (GO:1990089)2.80393313
141cellular response to nerve growth factor stimulus (GO:1990090)2.80393313
142tricarboxylic acid metabolic process (GO:0072350)2.79659423
143regulation of response to food (GO:0032095)2.79120074
144positive regulation of fibroblast migration (GO:0010763)2.78993324
145fatty acid homeostasis (GO:0055089)2.77431877
146hemoglobin metabolic process (GO:0020027)2.77165293
147positive regulation of neurotransmitter secretion (GO:0001956)2.77144216
148regulation of sulfur metabolic process (GO:0042762)2.76743840
149response to monoamine (GO:0071867)2.76655886
150response to catecholamine (GO:0071869)2.76655886
151regulation of erythrocyte differentiation (GO:0045646)2.76505538
152positive regulation of filopodium assembly (GO:0051491)2.75355496
153androgen biosynthetic process (GO:0006702)2.75190881
154thioester biosynthetic process (GO:0035384)2.75146086
155acyl-CoA biosynthetic process (GO:0071616)2.75146086
156positive regulation of nitric-oxide synthase activity (GO:0051000)2.74802299
157fatty acid beta-oxidation (GO:0006635)2.74745878
158axon extension (GO:0048675)2.74721398
159cerebellar granule cell differentiation (GO:0021707)2.72215274
160fatty-acyl-CoA biosynthetic process (GO:0046949)2.70722396
161cell migration in hindbrain (GO:0021535)2.69966243
162cellular response to leptin stimulus (GO:0044320)2.69862689
163ovulation from ovarian follicle (GO:0001542)2.68960982
164response to cold (GO:0009409)2.66131669
165gas transport (GO:0015669)2.65011111
166positive regulation of synapse maturation (GO:0090129)2.64886243
167CDP-diacylglycerol metabolic process (GO:0046341)2.64536401
168response to insecticide (GO:0017085)2.64332943
169phosphatidic acid biosynthetic process (GO:0006654)2.63139091
170phosphatidic acid metabolic process (GO:0046473)2.63139091
171leukocyte migration involved in inflammatory response (GO:0002523)2.63115063
172glycerol metabolic process (GO:0006071)2.62697140
173oxygen transport (GO:0015671)2.62684708
174regulation of norepinephrine secretion (GO:0014061)2.62364332
175axon cargo transport (GO:0008088)2.61627245
176long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.61053327
177protein heterotrimerization (GO:0070208)2.61034832
178relaxation of smooth muscle (GO:0044557)2.60823589
179positive regulation of histone deacetylation (GO:0031065)2.60695860
180positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.60406794
181dendrite morphogenesis (GO:0048813)2.60368935

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse9.38798455
2EZH2_22144423_ChIP-Seq_EOC_Human4.78431112
3TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.08638661
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.99076288
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.71976397
6* GBX2_23144817_ChIP-Seq_PC3_Human2.57923309
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.47249171
8* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.40961450
9ZNF263_19887448_ChIP-Seq_K562_Human2.40396480
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.38221391
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.38221391
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.29099145
13ZNF274_21170338_ChIP-Seq_K562_Hela2.26010367
14* RARB_27405468_Chip-Seq_BRAIN_Mouse2.24724610
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.23056071
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.21859266
17CLOCK_20551151_ChIP-Seq_293T_Human2.18708301
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.06167952
19GATA1_22025678_ChIP-Seq_K562_Human2.05994926
20LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.00894062
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.00705735
22ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.99186530
23REST_21632747_ChIP-Seq_MESCs_Mouse1.99016794
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.98435880
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.94568271
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.92318110
27* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.88428944
28IGF1R_20145208_ChIP-Seq_DFB_Human1.86335112
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.83353548
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.78274832
31RNF2_27304074_Chip-Seq_NSC_Mouse1.72459004
32* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.71249241
33TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.70564299
34* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.69321371
35* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68111383
36* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65260646
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.54730136
38AR_21572438_ChIP-Seq_LNCaP_Human1.52012531
39TAF15_26573619_Chip-Seq_HEK293_Human1.47514554
40GATA2_21666600_ChIP-Seq_HMVEC_Human1.46918024
41NR3C1_23031785_ChIP-Seq_PC12_Mouse1.45039364
42ELK4_26923725_Chip-Seq_MESODERM_Mouse1.44879073
43* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44516582
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43732635
45DROSHA_22980978_ChIP-Seq_HELA_Human1.43135753
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42718937
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42488707
48* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.41452717
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.40140638
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.36777449
51* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36004233
52* EZH2_27294783_Chip-Seq_ESCs_Mouse1.35656010
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.35045043
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.34679519
55EED_16625203_ChIP-ChIP_MESCs_Mouse1.34424028
56* GATA1_19941827_ChIP-Seq_MEL86_Mouse1.34355773
57AR_25329375_ChIP-Seq_VCAP_Human1.32788581
58TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31969334
59GATA1_22383799_ChIP-Seq_G1ME_Mouse1.30450235
60* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.30256550
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29378595
62* GATA1_19941826_ChIP-Seq_K562_Human1.27946172
63TRIM28_21343339_ChIP-Seq_HEK293_Human1.27811541
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.27449035
65STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26306631
66KDM2B_26808549_Chip-Seq_K562_Human1.25004485
67VDR_22108803_ChIP-Seq_LS180_Human1.24667843
68* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24181677
69RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.24118366
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23522418
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23413355
72* SPI1_23127762_ChIP-Seq_K562_Human1.22537790
73KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.22329722
74ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20191524
75EWS_26573619_Chip-Seq_HEK293_Human1.19068183
76KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18332515
77NCOR1_26117541_ChIP-Seq_K562_Human1.18234657
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16852910
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16622313
80* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.16382636
81* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.16382636
82OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16074798
83SMAD4_21799915_ChIP-Seq_A2780_Human1.14530717
84CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14034696
85EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13200849
86* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12993488
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10518722
88TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10518722
89LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10045065
90DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.09995633
91LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09878797
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09295840
93PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09139313
94POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08087748
95* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07701266
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07495422
97CBP_20019798_ChIP-Seq_JUKART_Human1.07495422
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05612273
99TCF4_23295773_ChIP-Seq_U87_Human1.05075017
100HTT_18923047_ChIP-ChIP_STHdh_Human1.04951025
101TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04934505
102ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03896497
103RXR_22108803_ChIP-Seq_LS180_Human1.03521316
104EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03264771
105* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03193115
106GF1_26923725_Chip-Seq_HPCs_Mouse1.03037002
107ERG_21242973_ChIP-ChIP_JURKAT_Human1.02662474
108GATA2_19941826_ChIP-Seq_K562_Human1.02150516
109TAL1_26923725_Chip-Seq_HPCs_Mouse1.01112822
110PIAS1_25552417_ChIP-Seq_VCAP_Human1.01077197
111YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00681815
112ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00597809
113* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99817790
114DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99153665
115CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.98858777
116* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98822900
117FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98045247
118NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97253838
119SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96139150
120TBL1_22424771_ChIP-Seq_293T_Human0.95039829
121GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94999869
122KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94811234
123BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94601846
124* IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94495258
125TCF4_18268006_ChIP-ChIP_LS174T_Human0.93958331
126* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93851043
127* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93342467
128TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93075815
129BCAT_22108803_ChIP-Seq_LS180_Human0.89637629
130P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89596336
131KDM2B_26808549_Chip-Seq_DND41_Human0.89364078
132* GATA1_19941827_ChIP-Seq_MEL_Mouse0.88653671
133SCL_19346495_ChIP-Seq_HPC-7_Human0.88337783
134JUN_21703547_ChIP-Seq_K562_Human0.87835640
135GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.87230744
136ESR1_20079471_ChIP-ChIP_T-47D_Human0.86369318
137HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.86367523
138AR_19668381_ChIP-Seq_PC3_Human0.85922157
139KDM2B_26808549_Chip-Seq_JURKAT_Human0.85613817
140TET1_21490601_ChIP-Seq_MESCs_Mouse0.84792312
141* STAT3_23295773_ChIP-Seq_U87_Human0.83717101
142P300_19829295_ChIP-Seq_ESCs_Human0.83500651
143CDX2_19796622_ChIP-Seq_MESCs_Mouse0.81580454
144CTNNB1_20460455_ChIP-Seq_HCT116_Human0.81194030

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology5.84338208
2MP0005670_abnormal_white_adipose5.31103269
3MP0008004_abnormal_stomach_pH4.93597665
4MP0004130_abnormal_muscle_cell4.38060322
5MP0005666_abnormal_adipose_tissue3.81909874
6MP0004859_abnormal_synaptic_plasticity3.53221627
7MP0004185_abnormal_adipocyte_glucose3.19730757
8MP0003724_increased_susceptibility_to3.12059254
9MP0005375_adipose_tissue_phenotype2.81906959
10MP0000013_abnormal_adipose_tissue2.77066978
11MP0002909_abnormal_adrenal_gland2.74157080
12MP0003828_pulmonary_edema2.70709047
13MP0002971_abnormal_brown_adipose2.58815318
14MP0002837_dystrophic_cardiac_calcinosis2.51452002
15MP0004084_abnormal_cardiac_muscle2.49895436
16MP0004270_analgesia2.41344843
17MP0001968_abnormal_touch/_nociception2.38690221
18MP0000465_gastrointestinal_hemorrhage2.34807933
19MP0003635_abnormal_synaptic_transmissio2.30205941
20MP0004147_increased_porphyrin_level2.27288812
21MP0000003_abnormal_adipose_tissue2.10788736
22MP0006276_abnormal_autonomic_nervous2.09605789
23MP0002733_abnormal_thermal_nociception2.08971806
24* MP0005535_abnormal_body_temperature2.07860045
25MP0003011_delayed_dark_adaptation2.07644644
26MP0002876_abnormal_thyroid_physiology2.06056018
27MP0002735_abnormal_chemical_nociception2.06053793
28MP0008438_abnormal_cutaneous_collagen2.00673474
29MP0002734_abnormal_mechanical_nocicepti1.98773909
30MP0005083_abnormal_biliary_tract1.98749923
31MP0005334_abnormal_fat_pad1.95211065
32MP0009780_abnormal_chondrocyte_physiolo1.93559909
33MP0009115_abnormal_fat_cell1.88823413
34MP0002063_abnormal_learning/memory/cond1.87973104
35MP0001348_abnormal_lacrimal_gland1.81984891
36* MP0002970_abnormal_white_adipose1.79069896
37MP0002736_abnormal_nociception_after1.77398594
38MP0008995_early_reproductive_senescence1.71958035
39MP0000343_altered_response_to1.65857476
40MP0005386_behavior/neurological_phenoty1.65322122
41MP0004924_abnormal_behavior1.65322122
42MP0001970_abnormal_pain_threshold1.63270544
43MP0003880_abnormal_central_pattern1.62622323
44MP0004510_myositis1.58753642
45MP0001501_abnormal_sleep_pattern1.54689814
46MP0000569_abnormal_digit_pigmentation1.51725363
47MP0003959_abnormal_lean_body1.49466492
48* MP0009745_abnormal_behavioral_response1.49455797
49MP0008877_abnormal_DNA_methylation1.47210621
50MP0004036_abnormal_muscle_relaxation1.46775743
51MP0003221_abnormal_cardiomyocyte_apopto1.45313717
52MP0003122_maternal_imprinting1.44942269
53MP0004811_abnormal_neuron_physiology1.40149779
54MP0005423_abnormal_somatic_nervous1.39675385
55MP0003646_muscle_fatigue1.38241021
56MP0005167_abnormal_blood-brain_barrier1.37677214
57MP0002572_abnormal_emotion/affect_behav1.35236094
58MP0002332_abnormal_exercise_endurance1.34494512
59* MP0005448_abnormal_energy_balance1.32841297
60* MP0005452_abnormal_adipose_tissue1.31715911
61MP0003656_abnormal_erythrocyte_physiolo1.30659563
62MP0008872_abnormal_physiological_respon1.28135247
63MP0009046_muscle_twitch1.25457252
64MP0000778_abnormal_nervous_system1.25019908
65MP0001486_abnormal_startle_reflex1.22493358
66MP0005645_abnormal_hypothalamus_physiol1.18186829
67MP0004858_abnormal_nervous_system1.17916291
68MP0003787_abnormal_imprinting1.15051435
69MP0006036_abnormal_mitochondrial_physio1.14422715
70MP0001879_abnormal_lymphatic_vessel1.14143105
71MP0002064_seizures1.13968755
72MP0003329_amyloid_beta_deposits1.13406878
73* MP0002078_abnormal_glucose_homeostasis1.13303955
74MP0002272_abnormal_nervous_system1.12247680
75MP0002184_abnormal_innervation1.12021643
76MP0002067_abnormal_sensory_capabilities1.08547946
77MP0001545_abnormal_hematopoietic_system1.07718916
78MP0005397_hematopoietic_system_phenotyp1.07718916
79MP0004085_abnormal_heartbeat1.07221436
80MP0008961_abnormal_basal_metabolism1.05916116
81MP0004484_altered_response_of1.03318028
82MP0001440_abnormal_grooming_behavior1.02464658
83MP0001851_eye_inflammation1.01931021
84MP0003186_abnormal_redox_activity1.00447227
85MP0003123_paternal_imprinting0.99572083
86MP0002972_abnormal_cardiac_muscle0.99303877
87MP0002638_abnormal_pupillary_reflex0.98985484
88MP0001661_extended_life_span0.98072153
89* MP0010329_abnormal_lipoprotein_level0.97223259
90MP0003121_genomic_imprinting0.96433312
91MP0000639_abnormal_adrenal_gland0.96033758
92MP0001177_atelectasis0.96022887
93MP0001188_hyperpigmentation0.95969865
94MP0005409_darkened_coat_color0.95665322
95MP0000751_myopathy0.94874683
96MP0008569_lethality_at_weaning0.93687018
97MP0008775_abnormal_heart_ventricle0.92991230
98MP0005275_abnormal_skin_tensile0.92036091
99* MP0002118_abnormal_lipid_homeostasis0.90906728
100MP0003283_abnormal_digestive_organ0.87210915
101MP0004215_abnormal_myocardial_fiber0.86230548
102MP0003948_abnormal_gas_homeostasis0.85624451
103MP0001529_abnormal_vocalization0.84917643
104MP0002557_abnormal_social/conspecific_i0.83533821
105MP0000955_abnormal_spinal_cord0.82352034
106* MP0002069_abnormal_eating/drinking_beha0.82048965
107MP0003890_abnormal_embryonic-extraembry0.81680027
108* MP0003953_abnormal_hormone_level0.80404647
109MP0005620_abnormal_muscle_contractility0.80356399
110MP0005084_abnormal_gallbladder_morpholo0.79457001
111MP0005646_abnormal_pituitary_gland0.79044122
112MP0000759_abnormal_skeletal_muscle0.78594062
113* MP0002066_abnormal_motor_capabilities/c0.78302519
114MP0003638_abnormal_response/metabolism_0.75535889
115MP0001986_abnormal_taste_sensitivity0.75433757
116MP0002822_catalepsy0.74388478
117MP0008874_decreased_physiological_sensi0.74104570
118MP0000249_abnormal_blood_vessel0.74036142
119MP0003566_abnormal_cell_adhesion0.73601324
120MP0003633_abnormal_nervous_system0.73399444
121MP0005647_abnormal_sex_gland0.72258099
122MP0005584_abnormal_enzyme/coenzyme_acti0.70616629
123MP0005187_abnormal_penis_morphology0.70035851
124MP0003690_abnormal_glial_cell0.67089929
125MP0002128_abnormal_blood_circulation0.66645414
126MP0004145_abnormal_muscle_electrophysio0.65708968
127MP0002882_abnormal_neuron_morphology0.64418810
128MP0002132_abnormal_respiratory_system0.64382404
129MP0005385_cardiovascular_system_phenoty0.63311169
130MP0001544_abnormal_cardiovascular_syste0.63311169
131MP0006138_congestive_heart_failure0.63294076
132MP0004142_abnormal_muscle_tone0.62307749
133MP0000230_abnormal_systemic_arterial0.61107266
134MP0003303_peritoneal_inflammation0.60484469
135MP0002152_abnormal_brain_morphology0.58570823
136MP0004087_abnormal_muscle_fiber0.58328324
137MP0003879_abnormal_hair_cell0.57042142
138MP0004233_abnormal_muscle_weight0.57021641
139MP0000681_abnormal_thyroid_gland0.56384005
140MP0001727_abnormal_embryo_implantation0.55506747

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)9.81867090
2Increased mean platelet volume (HP:0011877)9.33031616
3Abnormal platelet volume (HP:0011876)8.67738165
4Menorrhagia (HP:0000132)7.89675039
5Petechiae (HP:0000967)6.80976553
6Purpura (HP:0000979)6.32817784
7Oligomenorrhea (HP:0000876)5.76050967
8Epistaxis (HP:0000421)5.49369380
9Poikilocytosis (HP:0004447)5.05133800
10Impaired platelet aggregation (HP:0003540)4.87089633
11Abnormal platelet function (HP:0011869)4.87089633
12Gingival bleeding (HP:0000225)4.50422217
13Hyperlipoproteinemia (HP:0010980)4.42245213
14Spontaneous hematomas (HP:0007420)4.09168030
15Acanthocytosis (HP:0001927)4.03852300
16Papilledema (HP:0001085)3.91046266
17Gonadal dysgenesis (HP:0000133)3.68259885
18Poor eye contact (HP:0000817)3.68188045
19Polycythemia (HP:0001901)3.51307640
20Enlarged penis (HP:0000040)3.48382354
21Progressive inability to walk (HP:0002505)3.45685646
22Acanthosis nigricans (HP:0000956)3.32374410
23Abnormal social behavior (HP:0012433)3.31775085
24Impaired social interactions (HP:0000735)3.31775085
25Papillary thyroid carcinoma (HP:0002895)3.30758761
26Myokymia (HP:0002411)3.29182513
27Myoglobinuria (HP:0002913)3.24711041
28Hypertriglyceridemia (HP:0002155)3.12114387
29Pheochromocytoma (HP:0002666)3.07947632
30Visual hallucinations (HP:0002367)2.99474543
31Abnormal eating behavior (HP:0100738)2.96794628
32Polyphagia (HP:0002591)2.90696881
33Macroorchidism (HP:0000053)2.90513386
34Focal seizures (HP:0007359)2.90299129
35Abnormality of the heme biosynthetic pathway (HP:0010472)2.86150470
36Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.81768979
37Abnormality of alanine metabolism (HP:0010916)2.81768979
38Hyperalaninemia (HP:0003348)2.81768979
39Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.77539406
40Degeneration of the lateral corticospinal tracts (HP:0002314)2.77539406
41Neuroendocrine neoplasm (HP:0100634)2.76482217
42Limb dystonia (HP:0002451)2.74942313
43Conjunctival telangiectasia (HP:0000524)2.73364952
44Focal motor seizures (HP:0011153)2.72401180
45Hypercortisolism (HP:0001578)2.70700175
46Hyperthyroidism (HP:0000836)2.68034940
47Mutism (HP:0002300)2.67746326
48Insidious onset (HP:0003587)2.64940143
49Termporal pattern (HP:0011008)2.64940143
50Gonadotropin excess (HP:0000837)2.62429579
51Growth hormone excess (HP:0000845)2.61516742
52Abnormal hemoglobin (HP:0011902)2.59109417
53Increased muscle lipid content (HP:0009058)2.55646491
54Paralysis (HP:0003470)2.55519934
55Resting tremor (HP:0002322)2.52232679
56Difficulty running (HP:0009046)2.51297159
57Male infertility (HP:0003251)2.49124586
58Insomnia (HP:0100785)2.48958950
59Hyperpituitarism (HP:0010514)2.46292845
60Ventricular fibrillation (HP:0001663)2.45929844
61Relative macrocephaly (HP:0004482)2.45271605
62Neoplasm of the peripheral nervous system (HP:0100007)2.44289354
63Postural instability (HP:0002172)2.43707041
64Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.38686945
65Conjunctival hamartoma (HP:0100780)2.36903636
66Bruising susceptibility (HP:0000978)2.35590695
67Truncus arteriosus (HP:0001660)2.32395441
68Truncal ataxia (HP:0002078)2.31983691
69Anomalous pulmonary venous return (HP:0010772)2.30410893
70Torticollis (HP:0000473)2.29935636
71Atonic seizures (HP:0010819)2.26598709
72Inappropriate behavior (HP:0000719)2.26028209
73Increased variability in muscle fiber diameter (HP:0003557)2.25713112
74Action tremor (HP:0002345)2.25496683
75Abnormality of the corticospinal tract (HP:0002492)2.25163150
76Anxiety (HP:0000739)2.22851300
77Insulin-resistant diabetes mellitus (HP:0000831)2.22807610
78Thyroid carcinoma (HP:0002890)2.22776240
79Ankle clonus (HP:0011448)2.20263214
80Abnormality of the vasculature of the conjunctiva (HP:0008054)2.20013167
81Testicular neoplasm (HP:0010788)2.19250158
82Depression (HP:0000716)2.18747454
83Amyotrophic lateral sclerosis (HP:0007354)2.18310960
84Drooling (HP:0002307)2.18289045
85Excessive salivation (HP:0003781)2.18289045
86Epileptic encephalopathy (HP:0200134)2.18033641
87Supranuclear gaze palsy (HP:0000605)2.17029853
88Hyperacusis (HP:0010780)2.16514022
89Increased density of long bones (HP:0006392)2.16298828
90Neoplasm of the adrenal gland (HP:0100631)2.15682353
91Focal dystonia (HP:0004373)2.15176509
92Craniofacial dystonia (HP:0012179)2.15004803
93Diminished motivation (HP:0000745)2.14946469
94Agitation (HP:0000713)2.13801069
95Generalized tonic-clonic seizures (HP:0002069)2.11997324
96Febrile seizures (HP:0002373)2.10626337
97Impaired vibration sensation in the lower limbs (HP:0002166)2.09617129
98Bone cyst (HP:0012062)2.09545338
99Hamartoma of the eye (HP:0010568)2.08892241
100Inability to walk (HP:0002540)2.07219082
101Menstrual irregularities (HP:0000858)2.06209409
102Dyschromatopsia (HP:0007641)2.03900591
103Large hands (HP:0001176)2.02619450
104Lower limb muscle weakness (HP:0007340)2.01674178
105Buphthalmos (HP:0000557)2.01125515
106Abnormality of the vocal cords (HP:0008777)2.01001216
107Bradykinesia (HP:0002067)2.00054768
108Hypoventilation (HP:0002791)1.99928519
109Long foot (HP:0001833)1.99784077
110Abnormality of the common coagulation pathway (HP:0010990)1.97194632
111Scanning speech (HP:0002168)1.96865664
112Pachygyria (HP:0001302)1.93986695
113Nausea (HP:0002018)1.93614028
114Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.93114257
115Abnormality of the pulmonary veins (HP:0011718)1.93011865
116Urinary urgency (HP:0000012)1.92889473
117Urinary bladder sphincter dysfunction (HP:0002839)1.92576952
118Rhabdomyolysis (HP:0003201)1.92233723
119Large earlobe (HP:0009748)1.91712073
120Hyperglycinuria (HP:0003108)1.90623922
121Abnormal large intestine physiology (HP:0012700)1.90390785
122Reticulocytosis (HP:0001923)1.89770341
123Neonatal hypoglycemia (HP:0001998)1.89708330
124Sex reversal (HP:0012245)1.89705756
125Abnormal sex determination (HP:0012244)1.89705756
126Progressive microcephaly (HP:0000253)1.88578106
127Abnormality of pain sensation (HP:0010832)1.85374651
128Impaired pain sensation (HP:0007328)1.85374651
129Dysmetric saccades (HP:0000641)1.85338627
130Abnormal pupillary function (HP:0007686)1.83394846
131Accelerated skeletal maturation (HP:0005616)1.82773799
132Abnormality of skeletal muscle fiber size (HP:0012084)1.82322390
133Upper limb muscle weakness (HP:0003484)1.82156008
134Osteomalacia (HP:0002749)1.82012369
135Tinnitus (HP:0000360)1.81085432
136Hepatic necrosis (HP:0002605)1.80596465
137Bowel incontinence (HP:0002607)1.80593268
138Amblyopia (HP:0000646)1.79725347
139Lymphangioma (HP:0100764)1.79534366
140Broad-based gait (HP:0002136)1.78377227
141Cortical dysplasia (HP:0002539)1.77363833
142Nasal polyposis (HP:0100582)1.76083032
143Ileus (HP:0002595)1.75644461
144Facial diplegia (HP:0001349)1.74920921
145Bowel diverticulosis (HP:0005222)1.74264352
146Abnormality of binocular vision (HP:0011514)1.73468730
147Diplopia (HP:0000651)1.73468730
148Abnormal hair whorl (HP:0010721)1.72445251
149Complete atrioventricular canal defect (HP:0001674)1.71053318
150Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.69420121
151Precocious puberty (HP:0000826)1.69185532
152Acute myeloid leukemia (HP:0004808)1.68937934
153Hyperventilation (HP:0002883)1.67298082
154Absent/shortened dynein arms (HP:0200106)1.67186353
155Dynein arm defect of respiratory motile cilia (HP:0012255)1.67186353
156Muscle fiber splitting (HP:0003555)1.65903172
157Reduced subcutaneous adipose tissue (HP:0003758)1.65461049
158Abnormality of lateral ventricle (HP:0030047)1.64280450
159Myocardial infarction (HP:0001658)1.63915969
160Spastic gait (HP:0002064)1.59786742
161Atrioventricular canal defect (HP:0006695)1.59289007
162Cerebral hemorrhage (HP:0001342)1.58582318
163Failure to thrive in infancy (HP:0001531)1.56320623
164Male pseudohermaphroditism (HP:0000037)1.51006736
165Back pain (HP:0003418)1.50986329
166Delayed puberty (HP:0000823)1.46314080
167Rimmed vacuoles (HP:0003805)1.45494564

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.07277020
2CAMK1D3.74325776
3TRIB33.72789878
4CAMK1G2.97059159
5NTRK32.84230439
6TEC2.55871078
7BMX2.51750580
8MINK12.48273451
9MAP3K92.42584527
10MAP3K42.26925123
11MAP2K72.17907952
12SCYL22.13287972
13MAP3K122.07927387
14PDK31.97443329
15PDK41.97443329
16KSR21.92205242
17MYLK1.74434706
18MAPK131.69996034
19BTK1.66087308
20PRPF4B1.64272476
21LATS21.61142561
22MAP3K21.58502839
23MAP3K61.57825989
24PHKG21.53747353
25PHKG11.53747353
26DAPK21.51353294
27PNCK1.50966318
28RET1.49891866
29FRK1.48131997
30CAMKK21.47459279
31CDK51.46659504
32BMPR21.45477084
33KSR11.44952163
34DAPK11.44378040
35DYRK21.43714894
36MAP2K41.43169652
37NTRK21.39787350
38STK31.34069632
39NTRK11.32189133
40PAK61.30085638
41ERBB31.26197505
42LMTK21.26166871
43PTK2B1.23635121
44CAMKK11.23052991
45MST41.23027011
46CDK91.20913216
47SIK21.20092950
48PRKD31.20055054
49FGFR21.19656052
50YES11.14924144
51TAOK21.13336499
52RPS6KA21.11759484
53RIPK11.01937467
54BCKDK1.01872188
55MAP3K51.01544717
56MAP2K11.00835487
57FGFR30.99720991
58CSNK1G20.97766154
59PKN20.97503082
60FGR0.94503662
61GRK50.91140069
62SIK10.85265609
63DYRK1A0.82623656
64TAOK30.81067595
65HCK0.79509235
66PRKCH0.79083515
67ILK0.78162947
68PAK10.77559560
69PDGFRA0.76602051
70MUSK0.76120308
71EPHA40.75826977
72PRKAA20.75632477
73NLK0.75066483
74EEF2K0.74331910
75DYRK30.73245177
76PDK10.73222028
77PINK10.72023042
78PIK3CG0.70237564
79MARK20.70202318
80PDPK10.69939355
81CDK140.67621804
82RPS6KB10.67388428
83PRKG10.65621579
84SGK30.65588818
85TAOK10.64974946
86STK110.64751113
87STK40.64511254
88ARAF0.63192732
89PRKAA10.62803864
90PKN10.62036271
91ADRBK10.61571652
92TIE10.61177629
93EPHA30.60721808
94CAMK10.60591838
95DMPK0.60355852
96STK240.59021079
97SGK20.57765069
98CASK0.57000401
99FES0.55759840
100MAPK40.54917629
101CSNK1G30.54559186
102PDK20.54382011
103CDK180.52860639
104PRKCZ0.52776450
105PDGFRB0.51910457
106UHMK10.51772972
107MAP3K10.51295810
108PAK30.50818249
109MAP2K30.49819451
110PLK20.49252185
111CDK150.49085605
112ZAP700.48575778
113CDK60.48399976
114ERBB20.47463869
115LYN0.47302110
116CCNB10.45834631
117ADRBK20.45833137
118MAPKAPK30.44260356
119LIMK10.44145700
120MAPK120.44096374
121EPHB20.43322323
122SGK2230.42762327
123SGK4940.42762327
124TNIK0.42583422
125* PRKACG0.42506313
126CAMK2A0.42448139
127JAK20.42417672
128CSNK1G10.42253804
129EIF2AK10.41129730
130ACVR1B0.40673586
131RAF10.40212009
132CDK11A0.40182575
133CDK190.40002278
134WNK10.39631162
135PRKCG0.39518405
136TYRO30.36353216
137JAK10.35986320
138GRK60.35707832
139HIPK20.35002610
140SGK10.34645297
141MAPK100.34596598
142ROCK10.34503238
143PRKCB0.34450716
144RIPK40.33988036
145* RPS6KA30.32829065
146SYK0.32364017

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.93426854
2Regulation of lipolysis in adipocytes_Homo sapiens_hsa049233.59593145
3Fatty acid biosynthesis_Homo sapiens_hsa000613.08211870
4Propanoate metabolism_Homo sapiens_hsa006402.54777772
5PPAR signaling pathway_Homo sapiens_hsa033202.18073725
6Fatty acid metabolism_Homo sapiens_hsa012122.06832895
7Fatty acid elongation_Homo sapiens_hsa000622.02779918
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.83898686
9Renin secretion_Homo sapiens_hsa049241.81061749
10Steroid biosynthesis_Homo sapiens_hsa001001.80798368
11Dopaminergic synapse_Homo sapiens_hsa047281.74157202
12AMPK signaling pathway_Homo sapiens_hsa041521.67704447
13Olfactory transduction_Homo sapiens_hsa047401.67434124
14Circadian entrainment_Homo sapiens_hsa047131.63348280
15Adipocytokine signaling pathway_Homo sapiens_hsa049201.63189715
16Morphine addiction_Homo sapiens_hsa050321.60347434
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.59123869
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.57884521
19Synaptic vesicle cycle_Homo sapiens_hsa047211.56376125
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.55205673
21* Insulin signaling pathway_Homo sapiens_hsa049101.53383338
22Long-term potentiation_Homo sapiens_hsa047201.51539495
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.49643518
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46863806
25ECM-receptor interaction_Homo sapiens_hsa045121.42143775
26Fatty acid degradation_Homo sapiens_hsa000711.41387013
27Glycerolipid metabolism_Homo sapiens_hsa005611.40352118
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.39043889
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38448458
30Cholinergic synapse_Homo sapiens_hsa047251.38129934
31Salivary secretion_Homo sapiens_hsa049701.35807163
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35676559
33GABAergic synapse_Homo sapiens_hsa047271.34457483
34Gap junction_Homo sapiens_hsa045401.26453262
35Glutamatergic synapse_Homo sapiens_hsa047241.22573370
36Type II diabetes mellitus_Homo sapiens_hsa049301.22222046
37Nicotine addiction_Homo sapiens_hsa050331.20122089
38Glucagon signaling pathway_Homo sapiens_hsa049221.19098072
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.18063227
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17263595
41Glioma_Homo sapiens_hsa052141.15001218
42Cocaine addiction_Homo sapiens_hsa050301.13463231
43Pyruvate metabolism_Homo sapiens_hsa006201.13351838
44Longevity regulating pathway - mammal_Homo sapiens_hsa042111.11136993
45Oxytocin signaling pathway_Homo sapiens_hsa049211.08496840
46Oocyte meiosis_Homo sapiens_hsa041141.03792509
47Estrogen signaling pathway_Homo sapiens_hsa049151.03589295
48Chemokine signaling pathway_Homo sapiens_hsa040621.02051423
49Long-term depression_Homo sapiens_hsa047301.01977988
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.00819784
51Amphetamine addiction_Homo sapiens_hsa050310.99822687
52Ovarian steroidogenesis_Homo sapiens_hsa049130.99753449
53Neurotrophin signaling pathway_Homo sapiens_hsa047220.99627898
54cAMP signaling pathway_Homo sapiens_hsa040240.99571015
55Gastric acid secretion_Homo sapiens_hsa049710.99259736
56Insulin resistance_Homo sapiens_hsa049310.98833678
57Pancreatic secretion_Homo sapiens_hsa049720.97958203
58Serotonergic synapse_Homo sapiens_hsa047260.97154568
59GnRH signaling pathway_Homo sapiens_hsa049120.95922473
60mTOR signaling pathway_Homo sapiens_hsa041500.95050027
61Fat digestion and absorption_Homo sapiens_hsa049750.95035029
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.93866363
63beta-Alanine metabolism_Homo sapiens_hsa004100.93399620
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92685888
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89975072
66Endometrial cancer_Homo sapiens_hsa052130.89242893
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86766319
68Ras signaling pathway_Homo sapiens_hsa040140.86399783
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84990112
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.84590852
71Parkinsons disease_Homo sapiens_hsa050120.80876997
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80468516
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78820292
74Platelet activation_Homo sapiens_hsa046110.78457045
75Insulin secretion_Homo sapiens_hsa049110.78293386
76Non-small cell lung cancer_Homo sapiens_hsa052230.76300271
77Calcium signaling pathway_Homo sapiens_hsa040200.75158353
78B cell receptor signaling pathway_Homo sapiens_hsa046620.75149283
79ErbB signaling pathway_Homo sapiens_hsa040120.74479969
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.73377667
81Carbon metabolism_Homo sapiens_hsa012000.73042335
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72301231
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72042721
84VEGF signaling pathway_Homo sapiens_hsa043700.71774561
85Dilated cardiomyopathy_Homo sapiens_hsa054140.70837335
86Thyroid cancer_Homo sapiens_hsa052160.70117949
87Butanoate metabolism_Homo sapiens_hsa006500.69757431
88Melanogenesis_Homo sapiens_hsa049160.69065080
89Taste transduction_Homo sapiens_hsa047420.67677169
90Hematopoietic cell lineage_Homo sapiens_hsa046400.67436480
91Alcoholism_Homo sapiens_hsa050340.66931367
92Colorectal cancer_Homo sapiens_hsa052100.65467735
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65354263
94Axon guidance_Homo sapiens_hsa043600.65051738
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64148732
96MAPK signaling pathway_Homo sapiens_hsa040100.62192217
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60445308
98Alzheimers disease_Homo sapiens_hsa050100.58984780
99Chronic myeloid leukemia_Homo sapiens_hsa052200.57608853
100Renal cell carcinoma_Homo sapiens_hsa052110.56940411
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55154469
102Nitrogen metabolism_Homo sapiens_hsa009100.54615461
103Prolactin signaling pathway_Homo sapiens_hsa049170.54461755
104Choline metabolism in cancer_Homo sapiens_hsa052310.53471491
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53449594
106Arachidonic acid metabolism_Homo sapiens_hsa005900.52026117
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51783918
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.51655360
109Dorso-ventral axis formation_Homo sapiens_hsa043200.50751491
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49195425
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47941265
112Thyroid hormone synthesis_Homo sapiens_hsa049180.47868515
113Pancreatic cancer_Homo sapiens_hsa052120.47451101
114Acute myeloid leukemia_Homo sapiens_hsa052210.46597443
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44323324
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43073583
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42470141
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42413916
119FoxO signaling pathway_Homo sapiens_hsa040680.41083248
120Endocytosis_Homo sapiens_hsa041440.39967801
121HIF-1 signaling pathway_Homo sapiens_hsa040660.38271411
122Melanoma_Homo sapiens_hsa052180.37815355
123Focal adhesion_Homo sapiens_hsa045100.37766330
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.36746392
125Rap1 signaling pathway_Homo sapiens_hsa040150.36708802

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