PRKCA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.01972297
2synaptic vesicle maturation (GO:0016188)5.72338279
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.41670909
4locomotory exploration behavior (GO:0035641)5.34823296
5glutamate secretion (GO:0014047)5.06627159
6vocalization behavior (GO:0071625)5.02431221
7synaptic vesicle docking involved in exocytosis (GO:0016081)5.00241689
8synaptic vesicle exocytosis (GO:0016079)4.94561064
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.93196223
10regulation of synaptic vesicle exocytosis (GO:2000300)4.71287450
11cellular potassium ion homeostasis (GO:0030007)4.31264174
12protein localization to synapse (GO:0035418)4.28972482
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.24822109
14regulation of synaptic vesicle transport (GO:1902803)4.18065318
15regulation of glutamate receptor signaling pathway (GO:1900449)4.12627375
16regulation of neuronal synaptic plasticity (GO:0048168)4.04911525
17neuron cell-cell adhesion (GO:0007158)4.02657885
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.00793662
19exploration behavior (GO:0035640)4.00639659
20regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.97900590
21neurotransmitter secretion (GO:0007269)3.93329877
22regulation of long-term neuronal synaptic plasticity (GO:0048169)3.87534499
23sodium ion export (GO:0071436)3.84628819
24innervation (GO:0060384)3.77717474
25neuronal action potential propagation (GO:0019227)3.74264260
26postsynaptic membrane organization (GO:0001941)3.72085525
27synaptic transmission, glutamatergic (GO:0035249)3.67354686
28glutamate receptor signaling pathway (GO:0007215)3.63619047
29regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.63068860
30dendritic spine morphogenesis (GO:0060997)3.59544435
31regulation of synapse structural plasticity (GO:0051823)3.58829412
32layer formation in cerebral cortex (GO:0021819)3.56695767
33regulation of excitatory postsynaptic membrane potential (GO:0060079)3.53539037
34regulation of postsynaptic membrane potential (GO:0060078)3.50010373
35long-term memory (GO:0007616)3.48851553
36neuron-neuron synaptic transmission (GO:0007270)3.47878545
37proline transport (GO:0015824)3.45603761
38cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.43290315
39regulation of synaptic plasticity (GO:0048167)3.37497691
40positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.35776776
41activation of protein kinase A activity (GO:0034199)3.35648976
42long-term synaptic potentiation (GO:0060291)3.31929338
43positive regulation of membrane potential (GO:0045838)3.29762594
44regulation of ARF protein signal transduction (GO:0032012)3.28656640
45L-amino acid import (GO:0043092)3.28520887
46chemosensory behavior (GO:0007635)3.28346911
47neurotransmitter transport (GO:0006836)3.23472681
48membrane hyperpolarization (GO:0060081)3.20300347
49amino acid import (GO:0043090)3.19833179
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.17697844
51positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.14280933
52gamma-aminobutyric acid transport (GO:0015812)3.12846626
53neurotransmitter-gated ion channel clustering (GO:0072578)3.11092799
54regulation of dendritic spine morphogenesis (GO:0061001)3.10420091
55response to histamine (GO:0034776)3.10362354
56negative regulation of dendrite morphogenesis (GO:0050774)3.09815024
57cell communication by electrical coupling (GO:0010644)3.09352978
58neuron recognition (GO:0008038)3.09283091
59membrane depolarization during action potential (GO:0086010)3.08002903
60presynaptic membrane assembly (GO:0097105)3.07409594
61positive regulation of synapse maturation (GO:0090129)3.05863177
62vesicle transport along microtubule (GO:0047496)3.04660758
63regulation of vesicle fusion (GO:0031338)3.04361895
64regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.02642040
65positive regulation of neurotransmitter transport (GO:0051590)3.02478556
66regulation of neurotransmitter secretion (GO:0046928)3.01096963
67synaptic vesicle endocytosis (GO:0048488)3.00479050
68G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.00090993
69cerebellar Purkinje cell differentiation (GO:0021702)2.98822841
70dendrite morphogenesis (GO:0048813)2.97156731
71positive regulation of fibroblast migration (GO:0010763)2.95826530
72regulation of clathrin-mediated endocytosis (GO:2000369)2.95711952
73positive regulation of neurotransmitter secretion (GO:0001956)2.95001487
74membrane depolarization (GO:0051899)2.94575421
75cellular sodium ion homeostasis (GO:0006883)2.93930522
76axonal fasciculation (GO:0007413)2.93852857
77potassium ion import (GO:0010107)2.93549090
78membrane repolarization (GO:0086009)2.92621620
79regulation of voltage-gated calcium channel activity (GO:1901385)2.92047080
80potassium ion homeostasis (GO:0055075)2.91189796
81regulation of neurotransmitter levels (GO:0001505)2.90356446
82neuromuscular process controlling balance (GO:0050885)2.89743422
83regulation of axon extension involved in axon guidance (GO:0048841)2.89336751
84positive regulation of synaptic transmission, GABAergic (GO:0032230)2.88510767
85regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.87205839
86negative regulation of synaptic transmission, GABAergic (GO:0032229)2.86702369
87regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.85923580
88detection of calcium ion (GO:0005513)2.84367899
89regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.83786872
90response to gravity (GO:0009629)2.83628925
91regulation of synaptic transmission, glutamatergic (GO:0051966)2.81825430
92intraspecies interaction between organisms (GO:0051703)2.81326718
93social behavior (GO:0035176)2.81326718
94nerve growth factor signaling pathway (GO:0038180)2.80210471
95negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.80054043
96regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.79936810
97dendritic spine organization (GO:0097061)2.79332689
98cerebellar granule cell differentiation (GO:0021707)2.79255359
99neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.78720824
100gamma-aminobutyric acid signaling pathway (GO:0007214)2.78534096
101membrane assembly (GO:0071709)2.77725464
102protein localization to endosome (GO:0036010)2.77416800
103regulation of neurotransmitter transport (GO:0051588)2.77070337
104positive regulation of synaptic transmission (GO:0050806)2.76463086
105negative regulation of dendrite development (GO:2000171)2.74577337
106startle response (GO:0001964)2.74184777
107learning (GO:0007612)2.73802271
108behavioral defense response (GO:0002209)2.73693072
109behavioral fear response (GO:0001662)2.73693072
110synapse assembly (GO:0007416)2.73603232
111positive regulation of axon extension (GO:0045773)2.71885295
112positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.71859609
113G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.71488733
114positive regulation of potassium ion transmembrane transport (GO:1901381)2.69900040
115transmission of nerve impulse (GO:0019226)2.69521170
116suckling behavior (GO:0001967)2.68953380
117actin filament depolymerization (GO:0030042)2.68205589
118urinary tract smooth muscle contraction (GO:0014848)2.66263670
119presynaptic membrane organization (GO:0097090)2.59843015
120regulation of dendritic spine development (GO:0060998)2.55250829
121chondrocyte proliferation (GO:0035988)2.54050878
122import into cell (GO:0098657)2.53781922
123regulation of respiratory system process (GO:0044065)2.53287741
124pericardium development (GO:0060039)2.52099577
125dermatan sulfate metabolic process (GO:0030205)2.51518842
126dermatan sulfate biosynthetic process (GO:0030208)2.51451388
127cell adhesion mediated by integrin (GO:0033627)2.50878532
128regulation of axon guidance (GO:1902667)2.46539384
129chondroitin sulfate catabolic process (GO:0030207)2.45087621
130cytoskeletal anchoring at plasma membrane (GO:0007016)2.41442254
131collagen fibril organization (GO:0030199)2.41301769
132regulation of axon extension (GO:0030516)2.40856944
133astrocyte development (GO:0014002)2.39558039
134axon ensheathment in central nervous system (GO:0032291)2.35066260
135central nervous system myelination (GO:0022010)2.35066260
136negative regulation of axon extension (GO:0030517)2.32155585
137regulation of respiratory gaseous exchange (GO:0043576)2.31279743
138substrate-dependent cell migration (GO:0006929)2.28403353
139negative regulation of axon extension involved in axon guidance (GO:0048843)2.28010979
140positive regulation of dendritic spine development (GO:0060999)2.25714279
141positive regulation of extracellular matrix organization (GO:1903055)2.25305048
142acidic amino acid transport (GO:0015800)2.23282838
143positive regulation of dendrite development (GO:1900006)2.23240418
144protein targeting to plasma membrane (GO:0072661)2.22031038
145axon extension (GO:0048675)2.21061122
146cortical actin cytoskeleton organization (GO:0030866)2.20925186
147heparin metabolic process (GO:0030202)2.19717780
148heparin biosynthetic process (GO:0030210)2.19717780
149positive regulation of synapse assembly (GO:0051965)2.15063907

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.15647570
2GBX2_23144817_ChIP-Seq_PC3_Human3.33015019
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.90201602
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.86035112
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.73095321
6DROSHA_22980978_ChIP-Seq_HELA_Human2.66720319
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47870572
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47870572
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.44315794
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.43725633
11* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.42624381
12* RARB_27405468_Chip-Seq_BRAIN_Mouse2.40954893
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.39947767
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.34933089
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.34871184
16* REST_21632747_ChIP-Seq_MESCs_Mouse2.29634002
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.24017777
18* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.23198536
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.04154371
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.03485231
21RNF2_27304074_Chip-Seq_ESCs_Mouse1.97283701
22* EZH2_27294783_Chip-Seq_ESCs_Mouse1.94685181
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89802826
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.89755981
25* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.83741055
26* REST_18959480_ChIP-ChIP_MESCs_Mouse1.83118042
27AR_21572438_ChIP-Seq_LNCaP_Human1.77982832
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.73894143
29CJUN_26792858_Chip-Seq_BT549_Human1.72583779
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70182617
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.69931646
32* SMAD4_21799915_ChIP-Seq_A2780_Human1.69439840
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66097102
34* BRD4_25478319_ChIP-Seq_HGPS_Human1.63963365
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63746505
36GATA2_21666600_ChIP-Seq_HMVEC_Human1.61149685
37FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.57338851
38NR3C1_23031785_ChIP-Seq_PC12_Mouse1.55426475
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52169881
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49649156
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.49483411
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.48233711
43WT1_19549856_ChIP-ChIP_CCG9911_Human1.47016832
44* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41778569
45* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41300576
46NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.41230680
47NRF2_20460467_ChIP-Seq_MEFs_Mouse1.41230680
48CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.37484076
49* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35825436
50TP53_16413492_ChIP-PET_HCT116_Human1.34211071
51* SOX2_21211035_ChIP-Seq_LN229_Gbm1.33176067
52* STAT3_23295773_ChIP-Seq_U87_Human1.32122909
53NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.31253986
54* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28617317
55* AR_19668381_ChIP-Seq_PC3_Human1.28226294
56* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26221394
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24272373
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23358325
59P300_19829295_ChIP-Seq_ESCs_Human1.22719253
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.21725733
61AR_25329375_ChIP-Seq_VCAP_Human1.21703279
62* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21618425
63ZNF274_21170338_ChIP-Seq_K562_Hela1.21354162
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.20611674
65AHR_22903824_ChIP-Seq_MCF-7_Human1.20547753
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.19885054
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.18091458
68WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17589926
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.16891650
70P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15624622
71* FOXA2_19822575_ChIP-Seq_HepG2_Human1.15435621
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15269462
73* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15122651
74TAF15_26573619_Chip-Seq_HEK293_Human1.14814729
75* KDM2B_26808549_Chip-Seq_K562_Human1.13876589
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13807807
77* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13651339
78* TCF4_23295773_ChIP-Seq_U87_Human1.12578345
79* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12435945
80BCAT_22108803_ChIP-Seq_LS180_Human1.10771814
81KDM2B_26808549_Chip-Seq_REH_Human1.09888140
82* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09871368
83TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09630885
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09610562
85SMAD3_21741376_ChIP-Seq_HESCs_Human1.09396517
86* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08842792
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08701226
88* TP53_23651856_ChIP-Seq_MEFs_Mouse1.08367970
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07877859
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.07132160
91* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06905276
92JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05752336
93SMAD4_21741376_ChIP-Seq_HESCs_Human1.05349178
94PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04549272
95ESR1_20079471_ChIP-ChIP_T-47D_Human1.04502130
96DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04068285
97RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02896807
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01826339
99RXR_22108803_ChIP-Seq_LS180_Human1.01650408
100ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01297417
101RING1B_27294783_Chip-Seq_NPCs_Mouse1.01252787
102* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00513683
103* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99390258
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98887380
105NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98755444
106* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98264271
107* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.97716947
108GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97355166
109NANOG_18555785_Chip-Seq_ESCs_Mouse0.97263262
110RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97066168
111SMAD3_21741376_ChIP-Seq_ESCs_Human0.96987423
112* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96909346
113JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96855441
114EP300_21415370_ChIP-Seq_HL-1_Mouse0.96319741
115SOX9_26525672_Chip-Seq_HEART_Mouse0.95768730
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95694531
117TP53_18474530_ChIP-ChIP_U2OS_Human0.94505206
118GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93515577
119RARG_19884340_ChIP-ChIP_MEFs_Mouse0.93457006
120IGF1R_20145208_ChIP-Seq_DFB_Human0.89808756
121PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89522286
122POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89503255
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88875322
124DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88531880
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88436706
126ZFP281_18757296_ChIP-ChIP_E14_Mouse0.86173619
127SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85449815
128CTCF_27219007_Chip-Seq_Bcells_Human0.82521716

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.58327517
2MP0003880_abnormal_central_pattern4.29055441
3MP0004270_analgesia4.23236009
4MP0003635_abnormal_synaptic_transmissio3.92804289
5MP0008438_abnormal_cutaneous_collagen3.74353973
6MP0001968_abnormal_touch/_nociception3.71642508
7MP0002063_abnormal_learning/memory/cond3.06293386
8MP0009745_abnormal_behavioral_response2.99685964
9MP0002736_abnormal_nociception_after2.84599265
10MP0002064_seizures2.84282760
11MP0002735_abnormal_chemical_nociception2.81451731
12MP0005623_abnormal_meninges_morphology2.78201003
13MP0002734_abnormal_mechanical_nocicepti2.72691769
14MP0009780_abnormal_chondrocyte_physiolo2.64837871
15MP0001958_emphysema2.64416044
16MP0002909_abnormal_adrenal_gland2.53802503
17MP0005423_abnormal_somatic_nervous2.53004282
18MP0003950_abnormal_plasma_membrane2.52654261
19MP0002572_abnormal_emotion/affect_behav2.52374729
20MP0002272_abnormal_nervous_system2.50356475
21MP0002822_catalepsy2.48879806
22MP0003705_abnormal_hypodermis_morpholog2.40958638
23MP0001486_abnormal_startle_reflex2.39643627
24MP0009046_muscle_twitch2.38022141
25MP0002733_abnormal_thermal_nociception2.24116158
26MP0003279_aneurysm2.21438675
27MP0001970_abnormal_pain_threshold2.09155654
28MP0001501_abnormal_sleep_pattern2.05797888
29MP0010368_abnormal_lymphatic_system2.04032360
30MP0005551_abnormal_eye_electrophysiolog1.93595218
31MP0008569_lethality_at_weaning1.87482568
32MP0002067_abnormal_sensory_capabilities1.83866118
33MP0000534_abnormal_ureter_morphology1.79570470
34MP0004858_abnormal_nervous_system1.79128914
35MP0003091_abnormal_cell_migration1.78432117
36MP0004811_abnormal_neuron_physiology1.69081295
37MP0003329_amyloid_beta_deposits1.65822029
38MP0006054_spinal_hemorrhage1.60581101
39MP0004272_abnormal_basement_membrane1.60296073
40MP0001440_abnormal_grooming_behavior1.58194650
41MP0002184_abnormal_innervation1.57659522
42MP0004924_abnormal_behavior1.53432645
43MP0005386_behavior/neurological_phenoty1.53432645
44MP0002557_abnormal_social/conspecific_i1.49950595
45MP0003879_abnormal_hair_cell1.39703166
46MP0005257_abnormal_intraocular_pressure1.39374118
47MP0002882_abnormal_neuron_morphology1.38418497
48MP0006276_abnormal_autonomic_nervous1.35850403
49MP0002090_abnormal_vision1.35034205
50MP0005646_abnormal_pituitary_gland1.34943880
51MP0003633_abnormal_nervous_system1.32477135
52MP0010386_abnormal_urinary_bladder1.32344069
53MP0004885_abnormal_endolymph1.32186119
54MP0005503_abnormal_tendon_morphology1.31715328
55MP0003566_abnormal_cell_adhesion1.31562041
56MP0000778_abnormal_nervous_system1.31215499
57MP0002896_abnormal_bone_mineralization1.30802549
58MP0000955_abnormal_spinal_cord1.30446975
59MP0001984_abnormal_olfaction1.29786640
60MP0000569_abnormal_digit_pigmentation1.29714566
61MP0001502_abnormal_circadian_rhythm1.24844996
62MP0002066_abnormal_motor_capabilities/c1.24554093
63MP0000013_abnormal_adipose_tissue1.18308504
64MP0008961_abnormal_basal_metabolism1.17463690
65MP0009384_cardiac_valve_regurgitation1.17273557
66MP0010234_abnormal_vibrissa_follicle1.17268330
67MP0006072_abnormal_retinal_apoptosis1.17200997
68MP0005171_absent_coat_pigmentation1.16381801
69MP0002229_neurodegeneration1.16036944
70MP0003787_abnormal_imprinting1.14192674
71MP0003690_abnormal_glial_cell1.13366748
72MP0005023_abnormal_wound_healing1.12814296
73MP0001905_abnormal_dopamine_level1.10558084
74MP0002877_abnormal_melanocyte_morpholog1.07657311
75MP0000751_myopathy1.06870715
76MP0001188_hyperpigmentation1.06546188
77MP0000639_abnormal_adrenal_gland1.05140169
78MP0004145_abnormal_muscle_electrophysio1.04114707
79MP0001986_abnormal_taste_sensitivity1.02481702
80MP0005253_abnormal_eye_physiology1.02477128
81MP0003631_nervous_system_phenotype1.02095956
82MP0003045_fibrosis1.00552040
83MP0000767_abnormal_smooth_muscle1.00153706
84MP0005595_abnormal_vascular_smooth0.98675566
85MP0004134_abnormal_chest_morphology0.98156175
86MP0004510_myositis0.96903867
87MP0002837_dystrophic_cardiac_calcinosis0.96613981
88MP0008874_decreased_physiological_sensi0.96230537
89MP0001270_distended_abdomen0.96099075
90MP0010352_gastrointestinal_tract_polyps0.95713093
91MP0005645_abnormal_hypothalamus_physiol0.90510780
92MP0004085_abnormal_heartbeat0.90466739
93MP0008872_abnormal_physiological_respon0.88920569
94MP0003075_altered_response_to0.88852324
95MP0003283_abnormal_digestive_organ0.88521335
96MP0004484_altered_response_of0.87434894
97MP0005409_darkened_coat_color0.87411696
98MP0005535_abnormal_body_temperature0.87274933
99MP0002069_abnormal_eating/drinking_beha0.86860351
100MP0001299_abnormal_eye_distance/0.86292349
101MP0002168_other_aberrant_phenotype0.85521303
102MP0002152_abnormal_brain_morphology0.84999790
103MP0003942_abnormal_urinary_system0.84420648
104MP0000003_abnormal_adipose_tissue0.83498760
105MP0001177_atelectasis0.83001847
106MP0004215_abnormal_myocardial_fiber0.82047002
107MP0003385_abnormal_body_wall0.81866482
108MP0002295_abnormal_pulmonary_circulatio0.80275093
109MP0004233_abnormal_muscle_weight0.80247042
110MP0004084_abnormal_cardiac_muscle0.80065326
111MP0005360_urolithiasis0.78803901
112MP0001664_abnormal_digestion0.78599600
113MP0004043_abnormal_pH_regulation0.77675099
114MP0000538_abnormal_urinary_bladder0.76794063
115MP0003868_abnormal_feces_composition0.76622682
116MP0003634_abnormal_glial_cell0.76096228
117MP0003172_abnormal_lysosome_physiology0.75902747
118MP0009250_abnormal_appendicular_skeleto0.73933156
119MP0000747_muscle_weakness0.73149862
120MP0005174_abnormal_tail_pigmentation0.72346029
121MP0000733_abnormal_muscle_development0.72051141
122MP0004142_abnormal_muscle_tone0.71290484
123MP0000920_abnormal_myelination0.71124842
124MP0002752_abnormal_somatic_nervous0.70772951
125MP0001529_abnormal_vocalization0.70351791
126MP0000604_amyloidosis0.69875310
127MP0001243_abnormal_dermal_layer0.69146187
128MP0001765_abnormal_ion_homeostasis0.67815034
129MP0004036_abnormal_muscle_relaxation0.65234954
130MP0000428_abnormal_craniofacial_morphol0.64526591
131MP0005508_abnormal_skeleton_morphology0.64041970
132MP0005076_abnormal_cell_differentiation0.63798943
133MP0003183_abnormal_peptide_metabolism0.62487586
134MP0000462_abnormal_digestive_system0.62285498
135MP0001963_abnormal_hearing_physiology0.61370087
136MP0003122_maternal_imprinting0.61313557
137MP0005620_abnormal_muscle_contractility0.60286110
138MP0001943_abnormal_respiration0.58517261
139MP0001348_abnormal_lacrimal_gland0.56849302
140MP0003300_gastrointestinal_ulcer0.56617616
141MP0003632_abnormal_nervous_system0.56353819
142MP0005187_abnormal_penis_morphology0.53990115
143MP0004742_abnormal_vestibular_system0.53962335

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.51103799
2Myokymia (HP:0002411)5.59506659
3Focal seizures (HP:0007359)5.05236278
4Visual hallucinations (HP:0002367)4.85425337
5Congenital stationary night blindness (HP:0007642)4.67541135
6Premature rupture of membranes (HP:0001788)4.66390859
7Epileptic encephalopathy (HP:0200134)4.46644222
8Protrusio acetabuli (HP:0003179)4.39850598
9Progressive cerebellar ataxia (HP:0002073)4.10558044
10Absence seizures (HP:0002121)4.07113673
11Action tremor (HP:0002345)4.02946561
12Atonic seizures (HP:0010819)3.98896323
13Febrile seizures (HP:0002373)3.88871414
14Aortic aneurysm (HP:0004942)3.67969052
15Dialeptic seizures (HP:0011146)3.64190488
16Aortic dissection (HP:0002647)3.51689601
17Vascular tortuosity (HP:0004948)3.44329244
18Arterial tortuosity (HP:0005116)3.39450800
19Generalized tonic-clonic seizures (HP:0002069)3.32843635
20Truncal ataxia (HP:0002078)3.27441999
21Depression (HP:0000716)3.24590948
22Papilledema (HP:0001085)3.24316272
23Abnormality of macular pigmentation (HP:0008002)3.14746605
24Supranuclear gaze palsy (HP:0000605)3.12067714
25Broad-based gait (HP:0002136)3.05724405
26Poor eye contact (HP:0000817)3.02094983
27Impaired social interactions (HP:0000735)2.99084196
28Abnormal social behavior (HP:0012433)2.99084196
29Impaired vibration sensation in the lower limbs (HP:0002166)2.98519278
30Central scotoma (HP:0000603)2.98367186
31Dysmetria (HP:0001310)2.97159369
32Genetic anticipation (HP:0003743)2.96389603
33Spondylolisthesis (HP:0003302)2.93961622
34Dysdiadochokinesis (HP:0002075)2.92881509
35Gaze-evoked nystagmus (HP:0000640)2.92669319
36Urinary bladder sphincter dysfunction (HP:0002839)2.92142071
37Hyperventilation (HP:0002883)2.92054607
38Ankle clonus (HP:0011448)2.85558474
39Insidious onset (HP:0003587)2.82890131
40Termporal pattern (HP:0011008)2.82890131
41Anxiety (HP:0000739)2.80367739
42Shallow orbits (HP:0000586)2.79860274
43Wormian bones (HP:0002645)2.71050799
44Urinary urgency (HP:0000012)2.70867302
45Postural instability (HP:0002172)2.68337591
46Amblyopia (HP:0000646)2.61605027
47Scanning speech (HP:0002168)2.59626302
48Ventricular fibrillation (HP:0001663)2.59464727
49Impaired smooth pursuit (HP:0007772)2.58003703
50Epileptiform EEG discharges (HP:0011182)2.56536965
51Macroorchidism (HP:0000053)2.56180012
52Dysmetric saccades (HP:0000641)2.56084445
53Mitral stenosis (HP:0001718)2.54625428
54Broad face (HP:0000283)2.52977905
55Obstructive sleep apnea (HP:0002870)2.49989039
56Aortic regurgitation (HP:0001659)2.49321869
57Pheochromocytoma (HP:0002666)2.49099428
58Cervical subluxation (HP:0003308)2.46395035
59Ankle contracture (HP:0006466)2.44470595
60EEG with generalized epileptiform discharges (HP:0011198)2.40269911
61Drooling (HP:0002307)2.40098102
62Excessive salivation (HP:0003781)2.40098102
63Stereotypic behavior (HP:0000733)2.39096681
64Relative macrocephaly (HP:0004482)2.35195700
65Bowel diverticulosis (HP:0005222)2.34088524
66Hemiparesis (HP:0001269)2.31839634
67Dyschromatopsia (HP:0007641)2.31784507
68Intention tremor (HP:0002080)2.30518684
69Mitral regurgitation (HP:0001653)2.30269256
70Torticollis (HP:0000473)2.27920679
71Bladder diverticulum (HP:0000015)2.27884810
72Megalencephaly (HP:0001355)2.27472914
73Spastic gait (HP:0002064)2.27324101
74Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.26607109
75Abnormality of ocular smooth pursuit (HP:0000617)2.23593968
76Neonatal short-limb short stature (HP:0008921)2.23132949
77Spinal rigidity (HP:0003306)2.21413665
78Osteolytic defects of the hand bones (HP:0009699)2.20311468
79Osteolytic defects of the phalanges of the hand (HP:0009771)2.20311468
80Hypercortisolism (HP:0001578)2.20187578
81Cerebral inclusion bodies (HP:0100314)2.20110880
82Agitation (HP:0000713)2.19874084
83Abnormality of dentin (HP:0010299)2.19111194
84Hypsarrhythmia (HP:0002521)2.18427323
85Ulnar bowing (HP:0003031)2.18184353
86Follicular hyperkeratosis (HP:0007502)2.17304102
87Bradykinesia (HP:0002067)2.16555635
88Prolonged QT interval (HP:0001657)2.14737817
89Hypoventilation (HP:0002791)2.14572045
90Overgrowth (HP:0001548)2.14396092
91Bony spicule pigmentary retinopathy (HP:0007737)2.14390474
92Scotoma (HP:0000575)2.09143819
93Glucose intolerance (HP:0000833)2.09096133
94Mutism (HP:0002300)2.08115542
95Impaired vibratory sensation (HP:0002495)2.07898531
96Focal dystonia (HP:0004373)2.05418326
97Abnormal eating behavior (HP:0100738)2.02913497
98Neuroendocrine neoplasm (HP:0100634)2.02375494
99Abnormal EKG (HP:0003115)2.01713748
100Genu recurvatum (HP:0002816)2.01497085
101Slender build (HP:0001533)2.01172587
102Abnormality of the lower motor neuron (HP:0002366)2.00642321
103Absent speech (HP:0001344)1.99960850
104Bundle branch block (HP:0011710)1.98448632
105Ankyloglossia (HP:0010296)1.96322928
106Dilatation of the ascending aorta (HP:0005111)1.96029473
107Soft skin (HP:0000977)1.95837145
108Mild short stature (HP:0003502)1.95817051
109Lower limb asymmetry (HP:0100559)1.94881765
110Atrophic scars (HP:0001075)1.94630673
111Fragile skin (HP:0001030)1.93817402
112Rapidly progressive (HP:0003678)1.92179941
113Hemiplegia (HP:0002301)1.91896416
114Abnormality of the corticospinal tract (HP:0002492)1.91580149
115Progressive inability to walk (HP:0002505)1.90719460
116Neurofibrillary tangles (HP:0002185)1.90705901
117Lower limb amyotrophy (HP:0007210)1.89940908
118Hyperextensible skin (HP:0000974)1.88837621
119Gait ataxia (HP:0002066)1.87805354
120Short chin (HP:0000331)1.86896353
121Abnormality of carpal bone ossification (HP:0006257)1.86861747
122Abnormality of binocular vision (HP:0011514)1.86077391
123Diplopia (HP:0000651)1.86077391
124Biconcave vertebral bodies (HP:0004586)1.83981098
125Lower limb muscle weakness (HP:0007340)1.83702858
126Abnormal ossification of hand bones (HP:0005921)1.83669091
127Disproportionate tall stature (HP:0001519)1.81052411
128Narrow palate (HP:0000189)1.80999091
129Psychosis (HP:0000709)1.80764084
130Limb dystonia (HP:0002451)1.80477056
131Absent frontal sinuses (HP:0002688)1.79357209
132Mitral valve prolapse (HP:0001634)1.79171498
133Bradycardia (HP:0001662)1.79167617
134Postural tremor (HP:0002174)1.78754604
135Short nail (HP:0001799)1.78355963
136Hammertoe (HP:0001765)1.78117691
137Aneurysm (HP:0002617)1.76781514
138Blue irides (HP:0000635)1.76672556
139Long toe (HP:0010511)1.76652413
140Craniofacial dystonia (HP:0012179)1.76627735
141Abnormal rod and cone electroretinograms (HP:0008323)1.74517185
142Aqueductal stenosis (HP:0002410)1.73528207
143Insomnia (HP:0100785)1.73445280
144Decreased central vision (HP:0007663)1.73410250
145Vertebral compression fractures (HP:0002953)1.72682411
146Pointed chin (HP:0000307)1.72599335
147Impaired pain sensation (HP:0007328)1.72253337
148Abnormality of pain sensation (HP:0010832)1.72253337
149Heterotopia (HP:0002282)1.71617692
150Wide anterior fontanel (HP:0000260)1.71088396
151Annular pancreas (HP:0001734)1.70972678
152Generalized myoclonic seizures (HP:0002123)1.70746552
153Broad metatarsal (HP:0001783)1.70368749
154Joint laxity (HP:0001388)1.68285845
155Fair hair (HP:0002286)1.67863415
156Renal duplication (HP:0000075)1.66231630
157Cerebral aneurysm (HP:0004944)1.66113602
158Striae distensae (HP:0001065)1.65597542
159Tibial bowing (HP:0002982)1.65411357
160Delayed closure of the anterior fontanelle (HP:0001476)1.65388919
161Hypoplasia of the iris (HP:0007676)1.61831708
162Pulmonic stenosis (HP:0001642)1.61799042
163Syringomyelia (HP:0003396)1.61563103
164Spinal cord lesions (HP:0100561)1.61563103
165Abnormal glucose tolerance (HP:0001952)1.60752497
166Abnormal hand bone ossification (HP:0010660)1.60487993
167Open mouth (HP:0000194)1.58857942
168Hyperacusis (HP:0010780)1.57781075
169Submucous cleft hard palate (HP:0000176)1.56251377
170Cardiovascular calcification (HP:0011915)1.55136137
171Coronal craniosynostosis (HP:0004440)1.54913514
172Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.54730896

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.46647769
2EPHA43.80526224
3MAP3K93.52765569
4PRKD32.77384339
5MAP3K42.72032484
6MINK12.45424414
7KSR22.35300566
8RIPK42.31400458
9MARK12.27156366
10NTRK12.21191430
11PAK62.20244999
12CAMKK12.04073465
13MAP2K71.95588498
14MAP3K21.89573859
15DAPK21.87235972
16PTK21.77218422
17MAP2K41.71932914
18SIK21.58770402
19CDK51.58186009
20MET1.56692024
21TTN1.53517071
22LIMK11.52068116
23MYLK1.49547861
24NTRK21.45107023
25MAP3K121.41892558
26NEK91.39382357
27TRPM71.39135856
28KSR11.38515388
29LMTK21.36558363
30FRK1.36078383
31ICK1.34882860
32GRK51.34317386
33PRKCH1.31862637
34PNCK1.31660650
35RET1.30573127
36PDGFRB1.30164301
37FES1.29877519
38STK381.27842417
39PLK21.21887572
40SIK31.20513473
41DAPK11.17100238
42ROCK11.16242922
43PAK21.15617162
44MAP3K71.14421548
45MELK1.13871897
46NME11.10798157
47CAMK1G1.09375880
48CAMK11.07824484
49TRIM281.05198690
50MAP3K131.01458719
51PAK31.01143018
52PRKCG1.00282177
53CAMK2A0.99250709
54MST1R0.97531722
55ERBB40.97360217
56BCR0.96201297
57DMPK0.95443357
58PHKG10.94281689
59PHKG20.94281689
60CAMKK20.94255506
61JAK10.94098973
62FGFR30.92871862
63ARAF0.92760604
64PTK2B0.91912800
65MAP3K10.91845871
66SGK30.90850059
67SGK2230.90241197
68SGK4940.90241197
69UHMK10.88846569
70STK110.87497400
71ALK0.87331270
72CAMK2B0.86728288
73CDK120.82321561
74MARK20.82079148
75SCYL20.81436192
76SGK20.81096040
77TYRO30.81035347
78ROCK20.80659245
79MAPK130.79942761
80HIPK20.78504888
81PDPK10.77878953
82CAMK1D0.77623088
83LATS10.77486107
84* PDK10.77441530
85PRPF4B0.76902032
86RAF10.76535146
87MAPK110.76346171
88CDK140.75372118
89TAOK10.74935267
90SGK10.72541191
91CDC42BPA0.72326632
92CASK0.72059133
93WNK10.71052357
94CDK180.70587821
95CDK150.70330526
96CAMK2G0.66585855
97FER0.65711395
98CSNK1G20.65066832
99TNIK0.63828555
100FGFR20.63003021
101PINK10.59943289
102INSRR0.59866653
103LATS20.59480897
104PDGFRA0.59399217
105CDK11A0.58938150
106BRSK10.58181322
107FYN0.58085520
108ACVR1B0.57109469
109CAMK2D0.57056391
110RPS6KA30.54086197
111PKN10.52992403
112BMPR20.52268269
113PRKD20.52143543
114PRKCE0.51073879
115MAP2K10.50313483
116WNK40.49547036
117NEK60.49025317
118MTOR0.48662952
119RIPK10.48398230
120RPS6KA20.47328984
121FGFR40.46974898
122CDK190.46747418
123STK390.46255721
124TNK20.44738462
125TRIB30.44357426
126PIK3CA0.43632853
127MAPK100.43620892
128AKT30.43053170
129DYRK1A0.42459137
130MAPK120.42366492
131TGFBR20.42214945
132CAMK40.41577415
133DDR20.41029089

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.84208151
2Synaptic vesicle cycle_Homo sapiens_hsa047212.81548601
3Olfactory transduction_Homo sapiens_hsa047402.58284611
4* Long-term potentiation_Homo sapiens_hsa047202.57740839
5* Circadian entrainment_Homo sapiens_hsa047132.43652185
6* GABAergic synapse_Homo sapiens_hsa047272.29835417
7* Glutamatergic synapse_Homo sapiens_hsa047242.29203068
8* Amphetamine addiction_Homo sapiens_hsa050312.26128699
9* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.25822823
10* Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.24906793
11* Insulin secretion_Homo sapiens_hsa049112.16566075
12Phototransduction_Homo sapiens_hsa047442.08753789
13* Salivary secretion_Homo sapiens_hsa049702.05466242
14* Dopaminergic synapse_Homo sapiens_hsa047282.05001112
15* Morphine addiction_Homo sapiens_hsa050322.03693944
16* Cholinergic synapse_Homo sapiens_hsa047251.87182953
17* Gastric acid secretion_Homo sapiens_hsa049711.80926633
18* Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80617372
19Vitamin B6 metabolism_Homo sapiens_hsa007501.76942026
20Renin secretion_Homo sapiens_hsa049241.65661832
21* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.63486931
22* Oxytocin signaling pathway_Homo sapiens_hsa049211.60206232
23* Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.59893661
24Cocaine addiction_Homo sapiens_hsa050301.59124522
25ECM-receptor interaction_Homo sapiens_hsa045121.49047892
26* Serotonergic synapse_Homo sapiens_hsa047261.48221778
27Taste transduction_Homo sapiens_hsa047421.45821749
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.44594679
29* Long-term depression_Homo sapiens_hsa047301.44460221
30* Focal adhesion_Homo sapiens_hsa045101.42732675
31* Calcium signaling pathway_Homo sapiens_hsa040201.42102864
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41826782
33* GnRH signaling pathway_Homo sapiens_hsa049121.39267469
34Type II diabetes mellitus_Homo sapiens_hsa049301.36013199
35* Phosphatidylinositol signaling system_Homo sapiens_hsa040701.32976006
36Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.32323432
37cGMP-PKG signaling pathway_Homo sapiens_hsa040221.24841673
38* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24445352
39* Glioma_Homo sapiens_hsa052141.22697344
40cAMP signaling pathway_Homo sapiens_hsa040241.22648526
41Estrogen signaling pathway_Homo sapiens_hsa049151.20984554
42Nitrogen metabolism_Homo sapiens_hsa009101.18649858
43* Gap junction_Homo sapiens_hsa045401.17461840
44Carbohydrate digestion and absorption_Homo sapiens_hsa049731.09045420
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07859831
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.07374896
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.06012977
48Adherens junction_Homo sapiens_hsa045201.05232284
49* ErbB signaling pathway_Homo sapiens_hsa040121.02436215
50* Vascular smooth muscle contraction_Homo sapiens_hsa042700.98157896
51Dorso-ventral axis formation_Homo sapiens_hsa043200.96518729
52* Pancreatic secretion_Homo sapiens_hsa049720.95352588
53Dilated cardiomyopathy_Homo sapiens_hsa054140.94154285
54* Melanogenesis_Homo sapiens_hsa049160.92820754
55* Proteoglycans in cancer_Homo sapiens_hsa052050.92548121
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92071573
57Prion diseases_Homo sapiens_hsa050200.91053301
58Axon guidance_Homo sapiens_hsa043600.86576904
59* Thyroid hormone synthesis_Homo sapiens_hsa049180.86343685
60Collecting duct acid secretion_Homo sapiens_hsa049660.85054400
61* Phospholipase D signaling pathway_Homo sapiens_hsa040720.84850467
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.78417599
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77998189
64Hippo signaling pathway_Homo sapiens_hsa043900.76840683
65* Choline metabolism in cancer_Homo sapiens_hsa052310.76313641
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.76129391
67Melanoma_Homo sapiens_hsa052180.75358273
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75185997
69Lysine degradation_Homo sapiens_hsa003100.74903403
70Glucagon signaling pathway_Homo sapiens_hsa049220.74480757
71* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74457288
72* MicroRNAs in cancer_Homo sapiens_hsa052060.73979746
73* MAPK signaling pathway_Homo sapiens_hsa040100.73950711
74Chronic myeloid leukemia_Homo sapiens_hsa052200.73848504
75Circadian rhythm_Homo sapiens_hsa047100.73216398
76ABC transporters_Homo sapiens_hsa020100.73192566
77* VEGF signaling pathway_Homo sapiens_hsa043700.73108398
78Cardiac muscle contraction_Homo sapiens_hsa042600.72406094
79Inositol phosphate metabolism_Homo sapiens_hsa005620.70067404
80* Vibrio cholerae infection_Homo sapiens_hsa051100.69883202
81* mTOR signaling pathway_Homo sapiens_hsa041500.68603456
82* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68250325
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68102546
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66932805
85* Rap1 signaling pathway_Homo sapiens_hsa040150.65162038
86Ovarian steroidogenesis_Homo sapiens_hsa049130.64789780
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64564076
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63753150
89Fatty acid biosynthesis_Homo sapiens_hsa000610.63717690
90Oocyte meiosis_Homo sapiens_hsa041140.63422467
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61792253
92Endocytosis_Homo sapiens_hsa041440.60688385
93Endometrial cancer_Homo sapiens_hsa052130.60530358
94* Ras signaling pathway_Homo sapiens_hsa040140.57975756
95* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57666570
96* Sphingolipid signaling pathway_Homo sapiens_hsa040710.55554629
97Protein digestion and absorption_Homo sapiens_hsa049740.55304944
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55022012
99AMPK signaling pathway_Homo sapiens_hsa041520.54387598
100Renal cell carcinoma_Homo sapiens_hsa052110.53945677
101Insulin signaling pathway_Homo sapiens_hsa049100.53491441
102* Non-small cell lung cancer_Homo sapiens_hsa052230.51375013
103Pancreatic cancer_Homo sapiens_hsa052120.51097943
104Type I diabetes mellitus_Homo sapiens_hsa049400.50658070
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50436106
106Prolactin signaling pathway_Homo sapiens_hsa049170.50106469
107Bile secretion_Homo sapiens_hsa049760.49348239
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45886491
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45493596
110Platelet activation_Homo sapiens_hsa046110.44287602
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44038692
112Chemokine signaling pathway_Homo sapiens_hsa040620.42555010
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41034656
114* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40871094
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.39906199
116* Wnt signaling pathway_Homo sapiens_hsa043100.39324592
117T cell receptor signaling pathway_Homo sapiens_hsa046600.38061411
118Alcoholism_Homo sapiens_hsa050340.37327542
119Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35112358
120Colorectal cancer_Homo sapiens_hsa052100.34029855
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33110099
122* Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33098405
123Mineral absorption_Homo sapiens_hsa049780.32049716
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30439663
125Insulin resistance_Homo sapiens_hsa049310.29887667

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