PRKCDBP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene was identified as a binding protein of the protein kinase C, delta (PRKCD). The expression of this gene in cultured cell lines is strongly induced by serum starvation. The expression of this protein was found to be down-regulated in various cancer cell lines, suggesting the possible tumor suppressor function of this protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)6.89957855
2protein maturation by protein folding (GO:0022417)6.57860739
3type B pancreatic cell proliferation (GO:0044342)5.38066910
4collagen fibril organization (GO:0030199)5.24032170
5chondrocyte proliferation (GO:0035988)4.98520587
6barbed-end actin filament capping (GO:0051016)4.87798870
7skin morphogenesis (GO:0043589)4.60778500
8sequestering of extracellular ligand from receptor (GO:0035581)4.46479335
9COPI coating of Golgi vesicle (GO:0048205)4.39097634
10Golgi transport vesicle coating (GO:0048200)4.39097634
11muscle cell migration (GO:0014812)4.34558024
12basement membrane organization (GO:0071711)4.23988328
13retina vasculature morphogenesis in camera-type eye (GO:0061299)4.18212797
14vascular endothelial growth factor signaling pathway (GO:0038084)4.15940447
15extracellular fibril organization (GO:0043206)4.14912945
16negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.10805475
17regulation of tight junction assembly (GO:2000810)4.08583920
18regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.05162090
19regulation of metalloenzyme activity (GO:0048552)4.01247546
20actin filament depolymerization (GO:0030042)4.01217720
21nuclear envelope reassembly (GO:0031468)3.99118431
22mitotic nuclear envelope reassembly (GO:0007084)3.99118431
23fibril organization (GO:0097435)3.98669326
24endothelial cell morphogenesis (GO:0001886)3.98615041
25hemidesmosome assembly (GO:0031581)3.88460587
26establishment of viral latency (GO:0019043)3.88187538
27positive regulation of actin filament depolymerization (GO:0030836)3.85861022
28blood vessel maturation (GO:0001955)3.83762676
29collagen metabolic process (GO:0032963)3.74042281
30endothelium development (GO:0003158)3.73762987
31dermatan sulfate biosynthetic process (GO:0030208)3.68348869
32adhesion of symbiont to host cell (GO:0044650)3.67126128
33virion attachment to host cell (GO:0019062)3.67126128
34endothelial tube morphogenesis (GO:0061154)3.61568555
35morphogenesis of an endothelium (GO:0003159)3.61568555
36low-density lipoprotein particle clearance (GO:0034383)3.60327885
37establishment of integrated proviral latency (GO:0075713)3.59464910
38cell migration involved in heart development (GO:0060973)3.59419188
39endocardial cushion development (GO:0003197)3.58254985
40mesenchymal-epithelial cell signaling (GO:0060638)3.58129783
41cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.57999909
42collagen catabolic process (GO:0030574)3.57734289
43endodermal cell differentiation (GO:0035987)3.56651349
44multicellular organismal macromolecule metabolic process (GO:0044259)3.53436577
45positive regulation of endothelial cell apoptotic process (GO:2000353)3.50617093
46regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.47187286
47glomerular filtration (GO:0003094)3.46239163
48outer ear morphogenesis (GO:0042473)3.45676154
49positive regulation of pseudopodium assembly (GO:0031274)3.42472254
50dermatan sulfate metabolic process (GO:0030205)3.37750367
51negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.37312631
52multicellular organismal metabolic process (GO:0044236)3.36028942
53wound healing, spreading of epidermal cells (GO:0035313)3.34206784
54protein localization to endosome (GO:0036010)3.33840585
55renal filtration (GO:0097205)3.33488002
56bone trabecula formation (GO:0060346)3.33425882
57substrate-dependent cell migration (GO:0006929)3.31672230
58lymph vessel development (GO:0001945)3.29416944
59multicellular organismal catabolic process (GO:0044243)3.26366333
60white fat cell differentiation (GO:0050872)3.25623519
61stress fiber assembly (GO:0043149)3.21094336
62negative regulation of nitric-oxide synthase activity (GO:0051001)3.21000729
63extracellular matrix disassembly (GO:0022617)3.19616281
64lymphangiogenesis (GO:0001946)3.19390998
65cell-substrate junction assembly (GO:0007044)3.18561971
66neuron projection extension involved in neuron projection guidance (GO:1902284)3.14940722
67axon extension involved in axon guidance (GO:0048846)3.14940722
68protein localization to cell surface (GO:0034394)3.14493734
69cellular response to vitamin (GO:0071295)3.13432869
70pinocytosis (GO:0006907)3.10603515
71apoptotic cell clearance (GO:0043277)3.10469365
72positive regulation of epithelial to mesenchymal transition (GO:0010718)3.10107064
73positive regulation of blood vessel endothelial cell migration (GO:0043536)3.09673126
74adhesion of symbiont to host (GO:0044406)3.09375832
75regulation of pseudopodium assembly (GO:0031272)3.08011652
76epithelial cell-cell adhesion (GO:0090136)3.06081014
77negative regulation of catenin import into nucleus (GO:0035414)3.06080686
78metanephric mesenchyme development (GO:0072075)3.04449040
79extracellular matrix assembly (GO:0085029)3.04246010
80positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.03718504
81regulation of integrin-mediated signaling pathway (GO:2001044)3.03691019
82mesenchymal cell differentiation involved in kidney development (GO:0072161)3.03392095
83mesenchymal cell differentiation involved in renal system development (GO:2001012)3.03392095
84lipopolysaccharide biosynthetic process (GO:0009103)3.03054754
85regulation of extracellular matrix disassembly (GO:0010715)3.02731433
86endothelial cell chemotaxis (GO:0035767)2.95132785
87glomerular basement membrane development (GO:0032836)2.94270477
88negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.93624528
89UV protection (GO:0009650)2.92363267
90peptidyl-proline hydroxylation (GO:0019511)2.92180443
91middle ear morphogenesis (GO:0042474)2.92045522
92glomerular visceral epithelial cell development (GO:0072015)2.91886803
93plasma membrane repair (GO:0001778)2.91715720
94negative regulation of cartilage development (GO:0061037)2.91148518
95negative regulation of chondrocyte differentiation (GO:0032331)2.91142250
96hypotonic response (GO:0006971)2.86706851
97ventricular cardiac muscle cell development (GO:0055015)2.85605132
98protein targeting to plasma membrane (GO:0072661)2.84298622
99negative regulation of leukocyte chemotaxis (GO:0002689)2.84288343
100ovulation from ovarian follicle (GO:0001542)2.83812242
101regulation of gonadotropin secretion (GO:0032276)2.82612187
102negative regulation of fatty acid transport (GO:2000192)2.82597865
103negative regulation of smooth muscle cell migration (GO:0014912)2.81182672
104cardiac epithelial to mesenchymal transition (GO:0060317)2.80292766
105kidney mesenchyme development (GO:0072074)2.80029707
106membrane raft organization (GO:0031579)2.78823241
107regulation of collagen metabolic process (GO:0010712)2.74876735
108negative regulation of nitric oxide biosynthetic process (GO:0045019)2.73531726
109positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.73367883
110cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.72762244
111galactose catabolic process (GO:0019388)2.72652885
112extracellular matrix organization (GO:0030198)2.70765314
113cell migration involved in sprouting angiogenesis (GO:0002042)2.70011984
114extracellular structure organization (GO:0043062)2.69292530
115negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.68813792
116trabecula formation (GO:0060343)2.68182894
117vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.67529602
118heart trabecula formation (GO:0060347)2.67209207
119mesodermal cell differentiation (GO:0048333)2.66918884
120positive regulation of collagen biosynthetic process (GO:0032967)2.63822355
121positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.63007315
122atrioventricular valve morphogenesis (GO:0003181)2.62660468
123G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.62378734
124regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.61852179
125pattern specification involved in kidney development (GO:0061004)2.61840556
126brown fat cell differentiation (GO:0050873)2.61031353
127cell adhesion mediated by integrin (GO:0033627)2.60931279
128negative regulation of stem cell proliferation (GO:2000647)2.59630184
129embryonic skeletal joint morphogenesis (GO:0060272)2.59528961
130substrate adhesion-dependent cell spreading (GO:0034446)2.57483911
131regulation of smooth muscle cell migration (GO:0014910)2.57191628
132response to gravity (GO:0009629)2.56958212
133positive regulation of fatty acid oxidation (GO:0046321)2.56926346
134cellular copper ion homeostasis (GO:0006878)2.56542797
135cell proliferation involved in kidney development (GO:0072111)2.55590829
136extracellular negative regulation of signal transduction (GO:1900116)2.55428531
137extracellular regulation of signal transduction (GO:1900115)2.55428531
138proteasome assembly (GO:0043248)2.54291630
139hyaluronan catabolic process (GO:0030214)2.54246730
140glomerular epithelial cell development (GO:0072310)2.53485348
141adherens junction assembly (GO:0034333)2.53166075
142wound healing, spreading of cells (GO:0044319)2.52223067
143regulation of plasminogen activation (GO:0010755)2.51752892
144protein retention in ER lumen (GO:0006621)2.51633368
145GDP-mannose metabolic process (GO:0019673)2.51486673
146lung morphogenesis (GO:0060425)2.51428103
147endothelial cell proliferation (GO:0001935)2.50425966
148response to copper ion (GO:0046688)2.50089343
149mesenchyme morphogenesis (GO:0072132)2.49789530
150fibrinolysis (GO:0042730)2.48646708
151cardiac muscle cell proliferation (GO:0060038)2.47926771
152branching involved in salivary gland morphogenesis (GO:0060445)2.47149608
153cell proliferation involved in metanephros development (GO:0072203)2.45729641
154craniofacial suture morphogenesis (GO:0097094)2.45469942
155blood vessel endothelial cell migration (GO:0043534)2.45001490
156keratan sulfate catabolic process (GO:0042340)2.44268123
157glial cell migration (GO:0008347)2.43912628
158fibroblast migration (GO:0010761)2.43447245
159maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.42009125
160lipid particle organization (GO:0034389)2.40857557
161protein hydroxylation (GO:0018126)2.40186405

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.69685097
2TRIM28_21343339_ChIP-Seq_HEK293_Human6.48063315
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.92508453
4RARG_19884340_ChIP-ChIP_MEFs_Mouse5.06845164
5* CLOCK_20551151_ChIP-Seq_293T_Human3.58105562
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.53337903
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.16124102
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.95320507
9* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.80955487
10RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.57818440
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.45225558
12* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.24960309
13CJUN_26792858_Chip-Seq_BT549_Human2.21257606
14HIF1A_21447827_ChIP-Seq_MCF-7_Human2.17503105
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.16689118
16ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.08727369
17CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.07542451
18POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.04839516
19EP300_21415370_ChIP-Seq_HL-1_Mouse2.01443180
20SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.96836316
21* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.90035661
22EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.89051045
23WT1_19549856_ChIP-ChIP_CCG9911_Human1.84018630
24GATA2_21666600_ChIP-Seq_HMVEC_Human1.78798314
25ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.78001149
26WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.76631042
27* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.76368933
28TP53_20018659_ChIP-ChIP_R1E_Mouse1.70719546
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.69959460
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.69345776
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68958408
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.68732970
33SMC1_22415368_ChIP-Seq_MEFs_Mouse1.67821837
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.67246450
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.58606648
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.58425917
37CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56577140
38CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.54492411
39* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.53579032
40* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.53579032
41* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.53267302
42* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.51031733
43* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.51031733
44* BRD4_25478319_ChIP-Seq_HGPS_Human1.49039795
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.47532139
46* SOX2_20726797_ChIP-Seq_SW620_Human1.47204613
47ESR1_21235772_ChIP-Seq_MCF-7_Human1.44843488
48JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.44605420
49* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.44057471
50* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.44057471
51* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43441172
52* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.42218656
53E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41529539
54PPAR_26484153_Chip-Seq_NCI-H1993_Human1.41315464
55NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.40044684
56SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.39435257
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39307866
58SRY_22984422_ChIP-ChIP_TESTIS_Rat1.38996119
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.38420299
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37281902
61MYC_18358816_ChIP-ChIP_MESCs_Mouse1.37192122
62* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.37123748
63* TBX20_22328084_ChIP-Seq_HEART_Mouse1.36869091
64* TBX20_22080862_ChIP-Seq_HEART_Mouse1.36869091
65* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.36080859
66ATF3_27146783_Chip-Seq_COLON_Human1.35659764
67JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34201232
68P63_26484246_Chip-Seq_KERATINOCYTES_Human1.33376276
69RACK7_27058665_Chip-Seq_MCF-7_Human1.32205110
70* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.30420717
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.30408788
72* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.30404227
73TET1_21451524_ChIP-Seq_MESCs_Mouse1.28344599
74ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.28153391
75KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25822352
76ZNF263_19887448_ChIP-Seq_K562_Human1.25724818
77TP53_18474530_ChIP-ChIP_U2OS_Human1.24941639
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.24631799
79* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24126680
80MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.23778286
81LXR_22292898_ChIP-Seq_THP-1_Human1.22317495
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20928301
83UBF1/2_26484160_Chip-Seq_HMECs_Human1.20358920
84JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19882628
85CTCF_18555785_ChIP-Seq_MESCs_Mouse1.19379555
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18722068
87PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.17180353
88SA1_22415368_ChIP-Seq_MEFs_Mouse1.16426911
89RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16116716
90P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15841874
91* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.15379729
92* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15317624
93* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14723811
94KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14281630
95* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.13326982
96NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13219437
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10641928
98SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09326932
99NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09096993
100TP53_23651856_ChIP-Seq_MEFs_Mouse1.08536254
101NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07821170
102TP53_22127205_ChIP-Seq_IMR90_Human1.07713508
103SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04318525
104NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.03491202
105* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.01336875
106THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00663213
107TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99480389
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98579916
109NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98491444
110SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98116880
111SRF_21415370_ChIP-Seq_HL-1_Mouse0.97676059
112OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97661121
113FOXO3_23340844_ChIP-Seq_DLD1_Human0.95511919
114TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94944116
115EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.94775188
116RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94444670
117CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94214714
118* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93581339
119SOX2_18692474_ChIP-Seq_MEFs_Mouse0.92933064
120SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92157720
121SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.92104213
122MYC_18555785_ChIP-Seq_MESCs_Mouse0.91934931
123EZH2_27304074_Chip-Seq_ESCs_Mouse0.91726081
124* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91225755
125* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90926991
126ELK1_22589737_ChIP-Seq_MCF10A_Human0.89400979
127CSB_26484114_Chip-Seq_FIBROBLAST_Human0.89125821
128DCP1A_22483619_ChIP-Seq_HELA_Human0.88842212
129STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88671340
130TCF3_18692474_ChIP-Seq_MEFs_Mouse0.87725202
131CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.87547857
132TP53_16413492_ChIP-PET_HCT116_Human0.87344707
133* EOMES_21245162_ChIP-Seq_HESCs_Human0.86502750
134ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86426236
135* SOX17_20123909_ChIP-Seq_XEN_Mouse0.85191866
136FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.83583180
137ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81735608
138RNF2_27304074_Chip-Seq_ESCs_Mouse0.81562813
139TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.81121007
140KDM2B_26808549_Chip-Seq_K562_Human0.81118903
141KLF5_25053715_ChIP-Seq_YYC3_Human0.80285184

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.12725256
2MP0005275_abnormal_skin_tensile4.62772865
3MP0003279_aneurysm4.02617866
4MP0005503_abnormal_tendon_morphology3.75399850
5MP0003705_abnormal_hypodermis_morpholog3.72413991
6MP0004272_abnormal_basement_membrane3.63927826
7MP0001958_emphysema3.12443402
8MP0010368_abnormal_lymphatic_system3.09385543
9MP0000013_abnormal_adipose_tissue2.71210539
10MP0001879_abnormal_lymphatic_vessel2.57098183
11MP0006054_spinal_hemorrhage2.55697666
12MP0009384_cardiac_valve_regurgitation2.32581901
13MP0003191_abnormal_cellular_cholesterol2.24558899
14MP0005670_abnormal_white_adipose2.15935473
15MP0003566_abnormal_cell_adhesion2.05449347
16MP0002060_abnormal_skin_morphology1.98668510
17MP0000751_myopathy1.96671427
18MP0005623_abnormal_meninges_morphology1.95044190
19MP0010030_abnormal_orbit_morphology1.94775016
20MP0001542_abnormal_bone_strength1.92962238
21MP0000750_abnormal_muscle_regeneration1.87949033
22MP0005508_abnormal_skeleton_morphology1.75447000
23MP0002295_abnormal_pulmonary_circulatio1.69519481
24MP0004510_myositis1.69227560
25MP0009840_abnormal_foam_cell1.69082247
26MP0005666_abnormal_adipose_tissue1.68956319
27MP0009250_abnormal_appendicular_skeleto1.59911251
28MP0005375_adipose_tissue_phenotype1.58841089
29MP0000749_muscle_degeneration1.58835947
30MP0004185_abnormal_adipocyte_glucose1.58829287
31MP0005058_abnormal_lysosome_morphology1.56231327
32MP0002837_dystrophic_cardiac_calcinosis1.54606163
33MP0000003_abnormal_adipose_tissue1.54494968
34MP0005023_abnormal_wound_healing1.50739095
35MP0004130_abnormal_muscle_cell1.47062860
36MP0009379_abnormal_foot_pigmentation1.46032962
37MP0003091_abnormal_cell_migration1.45672795
38MP0000767_abnormal_smooth_muscle1.43111741
39MP0004084_abnormal_cardiac_muscle1.43071186
40MP0005595_abnormal_vascular_smooth1.42333504
41MP0003828_pulmonary_edema1.34605186
42MP0003385_abnormal_body_wall1.33661370
43MP0002108_abnormal_muscle_morphology1.32757838
44MP0001243_abnormal_dermal_layer1.32246369
45MP0009780_abnormal_chondrocyte_physiolo1.29759359
46MP0003724_increased_susceptibility_to1.23845008
47MP0002896_abnormal_bone_mineralization1.22428219
48MP0008775_abnormal_heart_ventricle1.21182663
49MP0000858_altered_metastatic_potential1.16113631
50MP0006138_congestive_heart_failure1.14873149
51MP0005167_abnormal_blood-brain_barrier1.14612520
52MP0000343_altered_response_to1.14200018
53MP0005197_abnormal_uvea_morphology1.13307988
54MP0002254_reproductive_system_inflammat1.09417572
55MP0000163_abnormal_cartilage_morphology1.07465290
56MP0005257_abnormal_intraocular_pressure1.06805353
57MP0009053_abnormal_anal_canal1.06542304
58MP0005620_abnormal_muscle_contractility1.06485640
59MP0005330_cardiomyopathy1.03963959
60MP0000733_abnormal_muscle_development1.03174340
61MP0000759_abnormal_skeletal_muscle1.02943160
62MP0002332_abnormal_exercise_endurance1.02327086
63MP0004087_abnormal_muscle_fiber1.02317297
64MP0005390_skeleton_phenotype1.02179098
65MP0003123_paternal_imprinting1.01201307
66MP0002128_abnormal_blood_circulation1.00900722
67MP0004036_abnormal_muscle_relaxation0.99280051
68MP0003186_abnormal_redox_activity0.98820363
69MP0001299_abnormal_eye_distance/0.98775817
70MP0001544_abnormal_cardiovascular_syste0.97512596
71MP0005385_cardiovascular_system_phenoty0.97512596
72MP0002282_abnormal_trachea_morphology0.96448133
73MP0003950_abnormal_plasma_membrane0.96267045
74MP0001849_ear_inflammation0.94739749
75MP0002972_abnormal_cardiac_muscle0.94451795
76MP0005164_abnormal_response_to0.94160741
77MP0002115_abnormal_skeleton_extremities0.93407271
78MP0002933_joint_inflammation0.91473380
79MP0008004_abnormal_stomach_pH0.90881406
80MP0003075_altered_response_to0.90571988
81MP0003329_amyloid_beta_deposits0.90499747
82MP0001614_abnormal_blood_vessel0.88892910
83MP0004215_abnormal_myocardial_fiber0.88837633
84MP0009115_abnormal_fat_cell0.87968055
85MP0000049_abnormal_middle_ear0.87943548
86MP0003942_abnormal_urinary_system0.87519502
87MP0004858_abnormal_nervous_system0.86980493
88MP0003045_fibrosis0.86111556
89MP0000249_abnormal_blood_vessel0.84997579
90MP0008260_abnormal_autophagy0.84669328
91MP0002796_impaired_skin_barrier0.84029383
92MP0005388_respiratory_system_phenotype0.82673036
93MP0002133_abnormal_respiratory_system0.82673036
94MP0002998_abnormal_bone_remodeling0.81581145
95MP0003941_abnormal_skin_development0.80190369
96MP0000747_muscle_weakness0.79101954
97MP0000762_abnormal_tongue_morphology0.77330682
98MP0001533_abnormal_skeleton_physiology0.76857314
99MP0005165_increased_susceptibility_to0.75915022
100MP0002249_abnormal_larynx_morphology0.75005728
101MP0004134_abnormal_chest_morphology0.74458585
102MP0010771_integument_phenotype0.74362776
103MP0002113_abnormal_skeleton_development0.73942375
104MP0002971_abnormal_brown_adipose0.72310359
105MP0001853_heart_inflammation0.71948028
106MP0005360_urolithiasis0.71732770
107MP0005193_abnormal_anterior_eye0.71631785
108MP0010630_abnormal_cardiac_muscle0.71593601
109MP0002177_abnormal_outer_ear0.71403659
110MP0005369_muscle_phenotype0.70816563
111MP0002089_abnormal_postnatal_growth/wei0.70667278
112MP0000534_abnormal_ureter_morphology0.70370753
113MP0002877_abnormal_melanocyte_morpholog0.69803750
114MP0001915_intracranial_hemorrhage0.68301108
115MP0004233_abnormal_muscle_weight0.67796195
116MP0002932_abnormal_joint_morphology0.67590483
117MP0004883_abnormal_blood_vessel0.67092821
118MP0002925_abnormal_cardiovascular_devel0.63376380
119MP0002168_other_aberrant_phenotype0.62958175
120MP0003795_abnormal_bone_structure0.62939324
121MP0000428_abnormal_craniofacial_morphol0.62684928
122MP0003115_abnormal_respiratory_system0.61903835
123MP0005501_abnormal_skin_physiology0.61597285
124MP0001175_abnormal_lung_morphology0.61106178
125MP0005171_absent_coat_pigmentation0.60368603
126MP0002106_abnormal_muscle_physiology0.53557835
127MP0003315_abnormal_perineum_morphology0.53323969
128MP0003453_abnormal_keratinocyte_physiol0.51172946

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)8.17191722
2Premature rupture of membranes (HP:0001788)7.72213814
3Aortic dissection (HP:0002647)5.18443140
4Atrophic scars (HP:0001075)4.65743004
5Soft skin (HP:0000977)4.62053790
6Aortic aneurysm (HP:0004942)4.59516796
7Ankle contracture (HP:0006466)4.40378020
8Cerebral aneurysm (HP:0004944)4.36884337
9Broad metatarsal (HP:0001783)4.30566175
10Fragile skin (HP:0001030)4.08620373
11Spinal rigidity (HP:0003306)4.08603375
12Increased connective tissue (HP:0009025)4.01461963
13Type 1 muscle fiber predominance (HP:0003803)3.92149147
14Vertebral compression fractures (HP:0002953)3.91598923
15Shallow orbits (HP:0000586)3.86650207
16Follicular hyperkeratosis (HP:0007502)3.80248814
17Biconcave vertebral bodies (HP:0004586)3.75615450
18Neonatal short-limb short stature (HP:0008921)3.74619107
19Peritonitis (HP:0002586)3.71000686
20Abnormality of dentin (HP:0010299)3.69816442
21Dilatation of the ascending aorta (HP:0005111)3.59676807
22Reduced subcutaneous adipose tissue (HP:0003758)3.53510975
23Increased variability in muscle fiber diameter (HP:0003557)3.38365602
24Bladder diverticulum (HP:0000015)3.34830602
25Wormian bones (HP:0002645)3.19923791
26Glucose intolerance (HP:0000833)3.05499682
27Blue sclerae (HP:0000592)3.03218695
28Abnormality of skeletal muscle fiber size (HP:0012084)3.01189315
29Joint stiffness (HP:0001387)2.97424764
30Mitral valve prolapse (HP:0001634)2.87659190
31Mildly elevated creatine phosphokinase (HP:0008180)2.80452635
32Distal upper limb amyotrophy (HP:0007149)2.76332827
33Upper limb amyotrophy (HP:0009129)2.76332827
34Vascular tortuosity (HP:0004948)2.75554399
35Short nail (HP:0001799)2.74733223
36Overgrowth (HP:0001548)2.71561312
37Distal lower limb amyotrophy (HP:0008944)2.71208074
38Hyperextensible skin (HP:0000974)2.70751957
39Cervical subluxation (HP:0003308)2.70688072
40Nonimmune hydrops fetalis (HP:0001790)2.67749559
41Entropion (HP:0000621)2.67606657
42Natal tooth (HP:0000695)2.65381212
43Cardiovascular calcification (HP:0011915)2.63424485
44Genu recurvatum (HP:0002816)2.63380769
45Acanthosis nigricans (HP:0000956)2.60607470
46Amyloidosis (HP:0011034)2.60573359
47Abnormal delivery (HP:0001787)2.60196285
48Hand muscle atrophy (HP:0009130)2.58693388
49Slender build (HP:0001533)2.52771185
50Aneurysm (HP:0002617)2.44944379
51Aplasia involving bones of the upper limbs (HP:0009823)2.43379629
52Aplasia of the phalanges of the hand (HP:0009802)2.43379629
53Aplasia involving bones of the extremities (HP:0009825)2.43379629
54Wrist flexion contracture (HP:0001239)2.41632799
55Arterial tortuosity (HP:0005116)2.39857829
56Upper limb muscle weakness (HP:0003484)2.38885209
57Muscle fiber splitting (HP:0003555)2.36445597
58Mitral regurgitation (HP:0001653)2.35056430
59Limb-girdle muscle atrophy (HP:0003797)2.33896593
60Venous abnormality (HP:0002624)2.33674000
61Abnormality of the distal phalanges of the toes (HP:0010182)2.33052296
62Scapular winging (HP:0003691)2.32754938
63Abnormality of the Achilles tendon (HP:0005109)2.32593857
64Elbow flexion contracture (HP:0002987)2.29430873
65Right ventricular cardiomyopathy (HP:0011663)2.27173322
66Abnormality of the acetabulum (HP:0003170)2.23835014
67Wide anterior fontanel (HP:0000260)2.22100713
68Vascular calcification (HP:0004934)2.20556749
69Abnormality of the umbilical cord (HP:0010881)2.19876001
70Short hallux (HP:0010109)2.19752516
71Round ear (HP:0100830)2.19153328
72Generalized amyotrophy (HP:0003700)2.16197170
73Rough bone trabeculation (HP:0100670)2.16113398
74Axonal loss (HP:0003447)2.15315365
75Infantile muscular hypotonia (HP:0008947)2.13922055
76Joint laxity (HP:0001388)2.11992315
77Spondylolisthesis (HP:0003302)2.10525785
78Difficulty climbing stairs (HP:0003551)2.09260909
79Calcaneovalgus deformity (HP:0001848)2.09211148
80Myocardial infarction (HP:0001658)2.08888364
81Osteolytic defects of the phalanges of the hand (HP:0009771)2.07619564
82Osteolytic defects of the hand bones (HP:0009699)2.07619564
83Venous insufficiency (HP:0005293)2.06562644
84Hyporeflexia of lower limbs (HP:0002600)2.06138675
85Short clavicles (HP:0000894)2.04097442
86Ectopia lentis (HP:0001083)2.02698881
87Coxa vara (HP:0002812)2.02672724
88Aplasia/Hypoplasia of the hallux (HP:0008362)2.02281478
89Abnormal glucose tolerance (HP:0001952)2.01260902
90Bowel diverticulosis (HP:0005222)1.98870444
91Insulin resistance (HP:0000855)1.98721279
92Deformed tarsal bones (HP:0008119)1.97474224
93Thin skin (HP:0000963)1.96545149
94Distal lower limb muscle weakness (HP:0009053)1.96173158
95Lipoatrophy (HP:0100578)1.96100334
96Limb-girdle muscle weakness (HP:0003325)1.94446587
97Adrenal hypoplasia (HP:0000835)1.93710697
98Beaking of vertebral bodies (HP:0004568)1.92512823
99Aortic valve stenosis (HP:0001650)1.92180700
100Achilles tendon contracture (HP:0001771)1.92088553
101Lower limb amyotrophy (HP:0007210)1.91955038
102Trismus (HP:0000211)1.91509738
103Buphthalmos (HP:0000557)1.89076742
104Deviation of the hallux (HP:0010051)1.88484744
105Breech presentation (HP:0001623)1.88465806
106Radial bowing (HP:0002986)1.87766472
107Microglossia (HP:0000171)1.87715611
108Delayed gross motor development (HP:0002194)1.86309369
109Mesangial abnormality (HP:0001966)1.85857303
110Aortic regurgitation (HP:0001659)1.84986187
111Hypoalphalipoproteinemia (HP:0003233)1.84061872
112Protruding ear (HP:0000411)1.82419052
113Neck muscle weakness (HP:0000467)1.81717298
114Aplasia/Hypoplasia of the clavicles (HP:0006710)1.80954086
115Congenital, generalized hypertrichosis (HP:0004540)1.80899620
116Camptodactyly of toe (HP:0001836)1.79532169
117Delayed cranial suture closure (HP:0000270)1.79358492
118Abnormality of skull ossification (HP:0002703)1.79238096
119Osteopenia (HP:0000938)1.76730642
120Coronal craniosynostosis (HP:0004440)1.76204660
121Flat capital femoral epiphysis (HP:0003370)1.74924036
122Bradycardia (HP:0001662)1.74272603
123Long toe (HP:0010511)1.74093665
124Osteoarthritis (HP:0002758)1.73269817
125Hallux valgus (HP:0001822)1.72751303
126Decreased skull ossification (HP:0004331)1.72130737
127Hydroureter (HP:0000072)1.71784939
128Fragile nails (HP:0001808)1.71730736
129Knee flexion contracture (HP:0006380)1.71645731
130Decreased subcutaneous fat (HP:0001002)1.71075835
131Abnormal hemoglobin (HP:0011902)1.68539554
132Abnormality of the calf musculature (HP:0001430)1.67813225
133Increased density of long bones (HP:0006392)1.67525312
134Bowing of the arm (HP:0006488)1.67320729
135Bowed forearm bones (HP:0003956)1.67320729
136Pulmonary artery stenosis (HP:0004415)1.66935423
137Ulnar bowing (HP:0003031)1.66855260
138Hypoventilation (HP:0002791)1.65879746
139Gastrointestinal dysmotility (HP:0002579)1.65119453
140Abnormality of the peritoneum (HP:0002585)1.64743353
141Myotonia (HP:0002486)1.64599553
142Mesomelia (HP:0003027)1.64091579

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.72615475
2TIE13.55523345
3VRK23.33738386
4TTN3.13964617
5MYLK3.09577450
6DDR23.00470280
7KDR2.97219403
8EPHA22.88469306
9LATS22.86564627
10ERN12.82370442
11EPHB22.60019147
12NME22.54111237
13TGFBR22.38510390
14FER2.18126450
15PDGFRA2.17459986
16PTK2B2.14072674
17LIMK12.12970501
18TESK12.04242285
19PKN21.99174466
20DMPK1.92369713
21LMTK21.87360230
22PAK21.85547031
23RIPK11.72258855
24TGFBR11.65844406
25ILK1.64496124
26SIK11.63588829
27PIK3CA1.53725942
28MAPKAPK31.51798786
29MOS1.50559006
30IRAK31.50085025
31PIM21.40958311
32BUB11.39937289
33LRRK21.36656103
34PIK3CG1.35335004
35ERBB41.28987166
36RPS6KA41.28547708
37NEK91.26936349
38MAP3K121.24550058
39LATS11.22674109
40TESK21.22465438
41PRKG21.21404202
42TRPM71.18194779
43MET1.12854662
44PTK21.08809071
45MAP3K111.05993346
46MAP3K31.04582824
47CAMK1D1.04452721
48MAP2K11.03407901
49EPHA31.02046791
50DAPK11.01634918
51ROCK11.01063291
52STK161.00409864
53PAK40.99834144
54STK100.99674662
55DAPK30.97029241
56PRKD30.93589961
57MAP2K30.93347144
58GRK70.93261768
59PHKG10.92879514
60PHKG20.92879514
61BRAF0.92149251
62BMX0.92021899
63GRK50.91944304
64PTK60.90984843
65MAP2K70.90126789
66PRKD10.84129140
67BCKDK0.83289449
68MST1R0.77851763
69MAP3K60.76425831
70PAK30.73949356
71PRPF4B0.72257757
72FGFR10.72150989
73ROCK20.71070682
74TBK10.68493705
75PDK20.67624291
76RET0.65648086
77PAK10.65179517
78PDK40.64790267
79PDK30.64790267
80SMG10.64367848
81AURKA0.63226855
82NEK10.62457133
83CAMKK20.62265990
84MAPK120.61943723
85STK380.61492633
86ICK0.61492202
87HIPK20.60618789
88GSK3A0.60364518
89ARAF0.58259952
90EPHB10.57942228
91MAPKAPK50.57373197
92PRKD20.55979130
93ADRBK10.52806771
94VRK10.51044674
95PDGFRB0.48040243
96CDC42BPA0.46852185
97FRK0.45840006
98CAMK2G0.45360979
99ABL20.45328739
100FLT30.42632472
101CSNK1G30.42310553
102CSNK1A1L0.42079152
103MAP3K80.41607142
104SRC0.41388226
105TAOK10.40247311
106STK38L0.39672294
107EEF2K0.39122619
108BRSK10.38012586
109INSR0.37376577
110SCYL20.37359102
111NTRK10.36583425
112PRKAA20.36383555
113IGF1R0.34047216
114MUSK0.33888456
115OBSCN0.33298617
116JAK30.33227905
117CAMK10.32895593
118CDK80.32867867
119CDK11A0.32806929
120CDK140.32660963
121CAMK1G0.32609853
122FGFR20.32197592
123CDK150.32062723
124FGFR30.31884522
125KIT0.31269462
126CDK180.29752095
127MAPKAPK20.29642281
128CDK70.29182161
129PAK60.29042493
130TAOK20.28227272
131MAP3K10.27910931
132RAF10.26646218
133PRKCH0.25770101
134AURKB0.23290932
135PRKCI0.22589508
136PRKCE0.22548251
137MINK10.22451367
138RPS6KA20.22000935
139MTOR0.21948975

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.13436911
2Proteasome_Homo sapiens_hsa030503.61023206
3Focal adhesion_Homo sapiens_hsa045103.02191671
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.75145141
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.72202376
6Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.68669562
7Dilated cardiomyopathy_Homo sapiens_hsa054142.37833703
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.36531893
9Folate biosynthesis_Homo sapiens_hsa007902.29833295
10Protein digestion and absorption_Homo sapiens_hsa049742.28819786
11AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.27890826
12Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.16503266
13Proteoglycans in cancer_Homo sapiens_hsa052052.13027324
14Galactose metabolism_Homo sapiens_hsa000522.11198552
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.10051863
16Glutathione metabolism_Homo sapiens_hsa004801.99041883
17Malaria_Homo sapiens_hsa051441.97818195
18Pentose phosphate pathway_Homo sapiens_hsa000301.90115155
19Other glycan degradation_Homo sapiens_hsa005111.86476100
20Amoebiasis_Homo sapiens_hsa051461.83989244
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.83591450
22Fatty acid elongation_Homo sapiens_hsa000621.81734627
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.79696985
24TGF-beta signaling pathway_Homo sapiens_hsa043501.65582718
25PPAR signaling pathway_Homo sapiens_hsa033201.63704865
26Bladder cancer_Homo sapiens_hsa052191.62177269
27PI3K-Akt signaling pathway_Homo sapiens_hsa041511.59883510
28Vibrio cholerae infection_Homo sapiens_hsa051101.55379012
29Biosynthesis of amino acids_Homo sapiens_hsa012301.54626826
30Ribosome_Homo sapiens_hsa030101.51690273
31Fatty acid biosynthesis_Homo sapiens_hsa000611.51380366
32Small cell lung cancer_Homo sapiens_hsa052221.49206075
33Fructose and mannose metabolism_Homo sapiens_hsa000511.46434227
34Adherens junction_Homo sapiens_hsa045201.45177084
35Oxidative phosphorylation_Homo sapiens_hsa001901.41117141
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.39508919
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.37047215
38Pyrimidine metabolism_Homo sapiens_hsa002401.34972230
39Platelet activation_Homo sapiens_hsa046111.33896087
40Huntingtons disease_Homo sapiens_hsa050161.32105312
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.31481867
42Hippo signaling pathway_Homo sapiens_hsa043901.31122253
43Vascular smooth muscle contraction_Homo sapiens_hsa042701.30406248
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.29884717
45Basal cell carcinoma_Homo sapiens_hsa052171.29481221
46Melanoma_Homo sapiens_hsa052181.26967575
47Sulfur metabolism_Homo sapiens_hsa009201.25452680
48DNA replication_Homo sapiens_hsa030301.23800758
49Adipocytokine signaling pathway_Homo sapiens_hsa049201.22118211
50Lysosome_Homo sapiens_hsa041421.20460438
51Tight junction_Homo sapiens_hsa045301.18386436
52Rap1 signaling pathway_Homo sapiens_hsa040151.17795654
53Regulation of actin cytoskeleton_Homo sapiens_hsa048101.10510068
54HIF-1 signaling pathway_Homo sapiens_hsa040661.05513937
55Nucleotide excision repair_Homo sapiens_hsa034201.02795344
56Shigellosis_Homo sapiens_hsa051311.01283653
57RNA polymerase_Homo sapiens_hsa030201.01244251
58Viral myocarditis_Homo sapiens_hsa054161.00062399
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98320602
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97245970
61Cardiac muscle contraction_Homo sapiens_hsa042600.95972343
62Pathways in cancer_Homo sapiens_hsa052000.95948239
63Gap junction_Homo sapiens_hsa045400.95138372
64Complement and coagulation cascades_Homo sapiens_hsa046100.95017255
65Base excision repair_Homo sapiens_hsa034100.94567633
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.94447719
67Hedgehog signaling pathway_Homo sapiens_hsa043400.94447014
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.93850108
69AMPK signaling pathway_Homo sapiens_hsa041520.92849353
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.90942622
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88470181
72Arachidonic acid metabolism_Homo sapiens_hsa005900.87651998
73Salivary secretion_Homo sapiens_hsa049700.87223798
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85924605
75Chronic myeloid leukemia_Homo sapiens_hsa052200.85070598
76Fatty acid metabolism_Homo sapiens_hsa012120.84568895
77Propanoate metabolism_Homo sapiens_hsa006400.83954650
78Melanogenesis_Homo sapiens_hsa049160.83875823
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83352401
80Thyroid cancer_Homo sapiens_hsa052160.79872586
81Toxoplasmosis_Homo sapiens_hsa051450.77740084
82VEGF signaling pathway_Homo sapiens_hsa043700.77397949
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77175108
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77059254
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74626838
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73764906
87Insulin signaling pathway_Homo sapiens_hsa049100.71979199
88Ras signaling pathway_Homo sapiens_hsa040140.71943746
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71075622
90MicroRNAs in cancer_Homo sapiens_hsa052060.68754338
91Prion diseases_Homo sapiens_hsa050200.68558186
92Insulin resistance_Homo sapiens_hsa049310.68210628
93Caffeine metabolism_Homo sapiens_hsa002320.67504991
94Glioma_Homo sapiens_hsa052140.66457879
95Sulfur relay system_Homo sapiens_hsa041220.65268392
96Wnt signaling pathway_Homo sapiens_hsa043100.65264792
97Fatty acid degradation_Homo sapiens_hsa000710.64997550
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64771952
99HTLV-I infection_Homo sapiens_hsa051660.62956662
100Renin secretion_Homo sapiens_hsa049240.62805639
101Pertussis_Homo sapiens_hsa051330.61256691
102TNF signaling pathway_Homo sapiens_hsa046680.61106764
103Tyrosine metabolism_Homo sapiens_hsa003500.60647897
104Parkinsons disease_Homo sapiens_hsa050120.60469510
105Pancreatic cancer_Homo sapiens_hsa052120.59539029
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59003409
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58149753
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57571369
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.57369378
110Nitrogen metabolism_Homo sapiens_hsa009100.56634379
111Phenylalanine metabolism_Homo sapiens_hsa003600.56563249
112Oxytocin signaling pathway_Homo sapiens_hsa049210.53905597
113Endocytosis_Homo sapiens_hsa041440.53181718
114Renal cell carcinoma_Homo sapiens_hsa052110.51770901
115Mismatch repair_Homo sapiens_hsa034300.51139912
116Salmonella infection_Homo sapiens_hsa051320.51110515
117Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50285505
118Estrogen signaling pathway_Homo sapiens_hsa049150.49609683
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49591028
120Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48404141
121Axon guidance_Homo sapiens_hsa043600.48018536
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.47797958
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47514747
124Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47474524
125p53 signaling pathway_Homo sapiens_hsa041150.46970030
126GnRH signaling pathway_Homo sapiens_hsa049120.46940508
127Phagosome_Homo sapiens_hsa041450.46279758
128Alzheimers disease_Homo sapiens_hsa050100.45183838
129Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44769905
130Thyroid hormone synthesis_Homo sapiens_hsa049180.43754621
131Carbon metabolism_Homo sapiens_hsa012000.41833334
132Pyruvate metabolism_Homo sapiens_hsa006200.40990471
133Glycerolipid metabolism_Homo sapiens_hsa005610.40817818
134Apoptosis_Homo sapiens_hsa042100.40651616
135Purine metabolism_Homo sapiens_hsa002300.40551215
136Prostate cancer_Homo sapiens_hsa052150.40392249
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39765984
138N-Glycan biosynthesis_Homo sapiens_hsa005100.39319232
139Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.37867609
140Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37534819
141Metabolic pathways_Homo sapiens_hsa011000.36386950

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