PRKCE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.18185420
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.15298090
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.90490200
4vocalization behavior (GO:0071625)5.50344786
5synaptic vesicle exocytosis (GO:0016079)5.48227857
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.45984316
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.38432444
8glutamate secretion (GO:0014047)5.35877696
9* locomotory exploration behavior (GO:0035641)5.25471722
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.11642157
11regulation of glutamate receptor signaling pathway (GO:1900449)5.10313009
12regulation of synaptic vesicle exocytosis (GO:2000300)5.00565741
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.83852192
14protein localization to synapse (GO:0035418)4.83839147
15regulation of neuronal synaptic plasticity (GO:0048168)4.67750417
16neuronal action potential propagation (GO:0019227)4.61018158
17regulation of long-term neuronal synaptic plasticity (GO:0048169)4.57387801
18regulation of synaptic vesicle transport (GO:1902803)4.50724322
19regulation of synapse structural plasticity (GO:0051823)4.39839643
20neuron cell-cell adhesion (GO:0007158)4.35369697
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.33506315
22neurotransmitter secretion (GO:0007269)4.32716460
23synaptic transmission, glutamatergic (GO:0035249)4.31372621
24cerebellar granule cell differentiation (GO:0021707)4.28933452
25* exploration behavior (GO:0035640)4.28123748
26glutamate receptor signaling pathway (GO:0007215)4.26830052
27neurotransmitter-gated ion channel clustering (GO:0072578)4.19056860
28dendritic spine morphogenesis (GO:0060997)4.11913947
29layer formation in cerebral cortex (GO:0021819)4.11403512
30negative regulation of dendrite morphogenesis (GO:0050774)4.07275905
31long-term memory (GO:0007616)4.05183932
32regulation of excitatory postsynaptic membrane potential (GO:0060079)4.00949715
33neuron-neuron synaptic transmission (GO:0007270)4.00766006
34amino acid import (GO:0043090)3.99994811
35positive regulation of membrane potential (GO:0045838)3.97295004
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.93084988
37proline transport (GO:0015824)3.82234271
38regulation of synaptic plasticity (GO:0048167)3.81376164
39potassium ion homeostasis (GO:0055075)3.79272600
40regulation of dendritic spine morphogenesis (GO:0061001)3.78515328
41cellular potassium ion homeostasis (GO:0030007)3.77970175
42gamma-aminobutyric acid transport (GO:0015812)3.77210637
43positive regulation of synapse maturation (GO:0090129)3.76362531
44regulation of postsynaptic membrane potential (GO:0060078)3.76036079
45potassium ion import (GO:0010107)3.72580748
46regulation of voltage-gated calcium channel activity (GO:1901385)3.64749655
47activation of protein kinase A activity (GO:0034199)3.56036253
48long-term synaptic potentiation (GO:0060291)3.55753217
49neuromuscular process controlling balance (GO:0050885)3.54351549
50sodium ion export (GO:0071436)3.50964820
51neurotransmitter transport (GO:0006836)3.46906752
52neuron recognition (GO:0008038)3.46726277
53cellular sodium ion homeostasis (GO:0006883)3.46651126
54positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.46350965
55regulation of neurotransmitter secretion (GO:0046928)3.41525908
56cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.40228240
57synaptic vesicle endocytosis (GO:0048488)3.40013680
58transmission of nerve impulse (GO:0019226)3.38280844
59regulation of synaptic transmission, glutamatergic (GO:0051966)3.36863497
60G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.34171026
61detection of calcium ion (GO:0005513)3.31075787
62regulation of vesicle fusion (GO:0031338)3.29033671
63regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.28240224
64innervation (GO:0060384)3.27471417
65gamma-aminobutyric acid signaling pathway (GO:0007214)3.27464721
66dendrite morphogenesis (GO:0048813)3.26336091
67membrane depolarization (GO:0051899)3.25412203
68negative regulation of synaptic transmission, GABAergic (GO:0032229)3.25193538
69cytoskeletal anchoring at plasma membrane (GO:0007016)3.24667880
70regulation of synapse maturation (GO:0090128)3.24553647
71regulation of neurotransmitter levels (GO:0001505)3.23632430
72postsynaptic membrane organization (GO:0001941)3.23564994
73cell communication by electrical coupling (GO:0010644)3.22741421
74auditory behavior (GO:0031223)3.20102383
75membrane depolarization during action potential (GO:0086010)3.19988993
76regulation of dendritic spine development (GO:0060998)3.19840628
77dendritic spine organization (GO:0097061)3.19350781
78axonal fasciculation (GO:0007413)3.19261862
79positive regulation of neurotransmitter secretion (GO:0001956)3.18063258
80behavioral defense response (GO:0002209)3.17147922
81behavioral fear response (GO:0001662)3.17147922
82vesicle transport along microtubule (GO:0047496)3.14929254
83cerebellar Purkinje cell differentiation (GO:0021702)3.14499545
84regulation of neurotransmitter transport (GO:0051588)3.13295564
85positive regulation of dendritic spine development (GO:0060999)3.11362365
86positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.09732403
87regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.08995401
88learning (GO:0007612)3.08563580
89axon ensheathment in central nervous system (GO:0032291)3.07884822
90central nervous system myelination (GO:0022010)3.07884822
91G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.07555159
92positive regulation of neurotransmitter transport (GO:0051590)3.07470702
93presynaptic membrane assembly (GO:0097105)3.07420277
94positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.05397194
95regulation of ARF protein signal transduction (GO:0032012)3.04601063
96chemosensory behavior (GO:0007635)3.04332415
97response to auditory stimulus (GO:0010996)3.04273430
98positive regulation of dendritic spine morphogenesis (GO:0061003)3.03979862
99neuromuscular process controlling posture (GO:0050884)3.03609591
100neuronal ion channel clustering (GO:0045161)3.03238062
101* regulation of synaptic transmission (GO:0050804)3.02608499
102membrane hyperpolarization (GO:0060081)2.99672720
103prepulse inhibition (GO:0060134)2.99314760
104neuromuscular process (GO:0050905)2.98617723
105long term synaptic depression (GO:0060292)2.97389035
106vesicle docking involved in exocytosis (GO:0006904)2.97251807
107response to histamine (GO:0034776)2.97230182
108negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.97194711
109fear response (GO:0042596)2.97163187
110L-amino acid import (GO:0043092)2.95815923
111synaptic transmission (GO:0007268)2.95221272
112regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.94899816
113glycine transport (GO:0015816)2.93816925
114acidic amino acid transport (GO:0015800)2.93254378
115* positive regulation of synaptic transmission (GO:0050806)2.93132259
116cell communication involved in cardiac conduction (GO:0086065)2.92527519
117neurotransmitter uptake (GO:0001504)2.88157223
118regulation of exocytosis (GO:0017157)2.87750540
119signal release (GO:0023061)2.83648176
120vesicle docking (GO:0048278)2.75528729
121cell differentiation in hindbrain (GO:0021533)2.75240969
122neuromuscular synaptic transmission (GO:0007274)2.72410394
123serotonin metabolic process (GO:0042428)2.69472596
124positive regulation of exocytosis (GO:0045921)2.64594753
125regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.64068881

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.11537923
2GBX2_23144817_ChIP-Seq_PC3_Human3.41686708
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.16316544
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11600451
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.09086646
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.76784413
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.75257851
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.75257851
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.74904966
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.65100329
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.63136866
12DROSHA_22980978_ChIP-Seq_HELA_Human2.62103959
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.58242521
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.55485759
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52118059
16* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46296761
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.44329193
18* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.25442475
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.24406318
20* REST_18959480_ChIP-ChIP_MESCs_Mouse2.24059583
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.22978645
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.21168754
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.11227907
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.06926829
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94012712
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88654121
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.87239420
28AR_21572438_ChIP-Seq_LNCaP_Human1.87120877
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.85882510
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77856850
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64240706
32SMAD4_21799915_ChIP-Seq_A2780_Human1.63365171
33* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60817292
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58406307
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.51817746
36TAF15_26573619_Chip-Seq_HEK293_Human1.50028809
37* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.44526691
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.39866279
39NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38694328
40* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34397661
41ZNF274_21170338_ChIP-Seq_K562_Hela1.33666389
42* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31504412
43* SOX2_21211035_ChIP-Seq_LN229_Gbm1.30575550
44* RING1B_27294783_Chip-Seq_ESCs_Mouse1.30405249
45RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29581141
46P300_19829295_ChIP-Seq_ESCs_Human1.28191208
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27527005
48DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27458886
49AR_25329375_ChIP-Seq_VCAP_Human1.24559862
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23592879
51* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22333245
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.22243728
53* SMAD3_21741376_ChIP-Seq_EPCs_Human1.22197778
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.21937489
55* AR_19668381_ChIP-Seq_PC3_Human1.21563075
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20543195
57* STAT3_23295773_ChIP-Seq_U87_Human1.20375630
58* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14230163
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13357316
60KDM2B_26808549_Chip-Seq_K562_Human1.13003042
61* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12046197
62TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10737056
63* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10614711
64* RING1B_27294783_Chip-Seq_NPCs_Mouse1.10610767
65* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10459445
66* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09380323
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.08473368
68* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07570614
69* GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07316157
70ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06840726
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.06357537
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05526241
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.05455265
74* TCF4_23295773_ChIP-Seq_U87_Human1.04311677
75* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04260301
76* EP300_21415370_ChIP-Seq_HL-1_Mouse1.03833432
77* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02486325
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02120123
79* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01493470
80AHR_22903824_ChIP-Seq_MCF-7_Human1.01190154
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00879686
82SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00789193
83PRDM14_20953172_ChIP-Seq_ESCs_Human0.99637908
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99506954
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98855959
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98385308
87MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98118097
88SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97669765
89* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97307372
90BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97195457
91SMAD3_21741376_ChIP-Seq_HESCs_Human0.97114258
92* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96150597
93SMAD4_21741376_ChIP-Seq_HESCs_Human0.95831996
94SMAD3_21741376_ChIP-Seq_ESCs_Human0.95375918
95IGF1R_20145208_ChIP-Seq_DFB_Human0.93981506
96GATA2_21666600_ChIP-Seq_HMVEC_Human0.93543587
97BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93007355
98* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91646037
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91580844
100TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91046210
101PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90772331
102* RUNX2_22187159_ChIP-Seq_PCA_Human0.90299759
103RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89452144
104RNF2_27304074_Chip-Seq_NSC_Mouse0.87980150
105KDM2B_26808549_Chip-Seq_REH_Human0.87334461
106* FOXA2_19822575_ChIP-Seq_HepG2_Human0.87147768
107ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86467135
108TET1_21490601_ChIP-Seq_MESCs_Mouse0.85093354
109CTCF_27219007_Chip-Seq_Bcells_Human0.84407061
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84120475
111* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83729054
112* TP53_16413492_ChIP-PET_HCT116_Human0.83585519
113* RXR_22108803_ChIP-Seq_LS180_Human0.83542511
114* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.82633609
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82577049
116* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.82477209
117LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81492746
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.80703745
119NANOG_18555785_Chip-Seq_ESCs_Mouse0.80244713
120EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.79122480
121TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.78972717

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.28295294
2MP0003880_abnormal_central_pattern4.78395341
3MP0003635_abnormal_synaptic_transmissio4.31170157
4MP0004270_analgesia4.00803509
5MP0002063_abnormal_learning/memory/cond3.46198337
6* MP0009745_abnormal_behavioral_response3.42653231
7MP0002064_seizures3.21377062
8MP0001968_abnormal_touch/_nociception3.17943198
9MP0009046_muscle_twitch2.95174900
10MP0002822_catalepsy2.85779852
11MP0002572_abnormal_emotion/affect_behav2.81259654
12MP0002734_abnormal_mechanical_nocicepti2.69390107
13MP0002272_abnormal_nervous_system2.63246820
14MP0005423_abnormal_somatic_nervous2.62302013
15MP0002735_abnormal_chemical_nociception2.57288012
16MP0001486_abnormal_startle_reflex2.53871448
17MP0002736_abnormal_nociception_after2.47229293
18MP0009780_abnormal_chondrocyte_physiolo2.32174421
19MP0001501_abnormal_sleep_pattern2.20560020
20MP0001440_abnormal_grooming_behavior2.13238854
21MP0002733_abnormal_thermal_nociception2.08058937
22MP0001970_abnormal_pain_threshold2.02020581
23MP0008569_lethality_at_weaning1.97433648
24MP0003329_amyloid_beta_deposits1.90722776
25MP0004858_abnormal_nervous_system1.90424732
26* MP0002067_abnormal_sensory_capabilities1.88850607
27MP0002909_abnormal_adrenal_gland1.81961919
28MP0004811_abnormal_neuron_physiology1.81569411
29MP0002184_abnormal_innervation1.74085767
30MP0000778_abnormal_nervous_system1.70657047
31MP0004924_abnormal_behavior1.68401719
32MP0005386_behavior/neurological_phenoty1.68401719
33MP0002557_abnormal_social/conspecific_i1.67164756
34MP0003879_abnormal_hair_cell1.61701074
35MP0005646_abnormal_pituitary_gland1.58993268
36MP0000955_abnormal_spinal_cord1.54061285
37MP0004885_abnormal_endolymph1.51422498
38MP0003633_abnormal_nervous_system1.44676835
39MP0001348_abnormal_lacrimal_gland1.42650679
40* MP0002066_abnormal_motor_capabilities/c1.40798677
41MP0006276_abnormal_autonomic_nervous1.39583442
42MP0002882_abnormal_neuron_morphology1.39085767
43MP0001986_abnormal_taste_sensitivity1.35380939
44MP0001984_abnormal_olfaction1.34073424
45MP0003787_abnormal_imprinting1.29770573
46MP0003631_nervous_system_phenotype1.19699556
47MP0005645_abnormal_hypothalamus_physiol1.17578861
48MP0001502_abnormal_circadian_rhythm1.16492090
49MP0001905_abnormal_dopamine_level1.15857870
50MP0003045_fibrosis1.09946448
51MP0003123_paternal_imprinting1.08827884
52MP0004142_abnormal_muscle_tone1.08109489
53MP0002152_abnormal_brain_morphology1.05610951
54MP0003075_altered_response_to1.05247217
55MP0000751_myopathy1.03873904
56MP0001529_abnormal_vocalization1.03132794
57MP0008872_abnormal_physiological_respon1.00430415
58MP0008874_decreased_physiological_sensi1.00183113
59MP0001188_hyperpigmentation0.99574652
60MP0002638_abnormal_pupillary_reflex0.98609287
61MP0002229_neurodegeneration0.95157127
62MP0004145_abnormal_muscle_electrophysio0.94451997
63MP0001177_atelectasis0.91123424
64MP0005535_abnormal_body_temperature0.90853223
65MP0000569_abnormal_digit_pigmentation0.90520967
66* MP0002069_abnormal_eating/drinking_beha0.90385036
67MP0004085_abnormal_heartbeat0.89757298
68MP0000013_abnormal_adipose_tissue0.88978584
69MP0003690_abnormal_glial_cell0.88755264
70MP0008961_abnormal_basal_metabolism0.86910665
71MP0000604_amyloidosis0.86431844
72MP0000920_abnormal_myelination0.86404854
73MP0003122_maternal_imprinting0.86343232
74MP0004510_myositis0.86001278
75MP0003634_abnormal_glial_cell0.82701895
76MP0002837_dystrophic_cardiac_calcinosis0.81298153
77MP0004742_abnormal_vestibular_system0.80308739
78MP0003632_abnormal_nervous_system0.79613807
79MP0005551_abnormal_eye_electrophysiolog0.79601282
80MP0004215_abnormal_myocardial_fiber0.77541781
81MP0004484_altered_response_of0.77498258
82MP0010386_abnormal_urinary_bladder0.76837837
83MP0001963_abnormal_hearing_physiology0.76610516
84MP0004147_increased_porphyrin_level0.74462866
85MP0002090_abnormal_vision0.72011242
86MP0003283_abnormal_digestive_organ0.70302298
87MP0005409_darkened_coat_color0.69548469
88MP0005167_abnormal_blood-brain_barrier0.68000297
89MP0010234_abnormal_vibrissa_follicle0.67974119
90MP0004043_abnormal_pH_regulation0.66867816
91MP0002752_abnormal_somatic_nervous0.65907078
92MP0003137_abnormal_impulse_conducting0.64497801
93MP0001664_abnormal_digestion0.63719260
94MP0000015_abnormal_ear_pigmentation0.62590802
95MP0004130_abnormal_muscle_cell0.61409869
96MP0004233_abnormal_muscle_weight0.61156994
97MP0003172_abnormal_lysosome_physiology0.60085058
98MP0001346_abnormal_lacrimal_gland0.60055137
99MP0000631_abnormal_neuroendocrine_gland0.59691358
100MP0001485_abnormal_pinna_reflex0.57694566
101MP0005394_taste/olfaction_phenotype0.56404014
102MP0005499_abnormal_olfactory_system0.56404014
103MP0000639_abnormal_adrenal_gland0.55665755
104MP0002876_abnormal_thyroid_physiology0.53889662
105MP0002332_abnormal_exercise_endurance0.53330141
106MP0010769_abnormal_survival0.49836716
107MP0001943_abnormal_respiration0.49445926
108MP0002082_postnatal_lethality0.49279742
109MP0010770_preweaning_lethality0.49279742
110MP0005623_abnormal_meninges_morphology0.49098937
111MP0010768_mortality/aging0.48823433
112* MP0003956_abnormal_body_size0.48472808
113MP0001299_abnormal_eye_distance/0.46719499
114MP0001765_abnormal_ion_homeostasis0.46546335
115MP0003183_abnormal_peptide_metabolism0.46431895
116MP0001944_abnormal_pancreas_morphology0.43693172
117MP0003091_abnormal_cell_migration0.42938404
118MP0005166_decreased_susceptibility_to0.42837239
119MP0003303_peritoneal_inflammation0.41614246

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.94505080
2Myokymia (HP:0002411)7.67945076
3Focal seizures (HP:0007359)5.92732176
4Visual hallucinations (HP:0002367)5.35561982
5Epileptic encephalopathy (HP:0200134)4.90759669
6Atonic seizures (HP:0010819)4.59086250
7Febrile seizures (HP:0002373)4.42075354
8Progressive cerebellar ataxia (HP:0002073)4.41842624
9Action tremor (HP:0002345)4.39124039
10Absence seizures (HP:0002121)4.15773560
11Dialeptic seizures (HP:0011146)3.89279608
12Generalized tonic-clonic seizures (HP:0002069)3.88209236
13Supranuclear gaze palsy (HP:0000605)3.66618259
14Broad-based gait (HP:0002136)3.58656446
15Poor eye contact (HP:0000817)3.56912921
16Impaired vibration sensation in the lower limbs (HP:0002166)3.54581324
17Ankle clonus (HP:0011448)3.46643658
18Gaze-evoked nystagmus (HP:0000640)3.44124183
19Depression (HP:0000716)3.40279469
20Papilledema (HP:0001085)3.31492390
21Hyperventilation (HP:0002883)3.27490141
22Dysmetria (HP:0001310)3.26965380
23Impaired social interactions (HP:0000735)3.23062826
24Abnormal social behavior (HP:0012433)3.23062826
25Dysdiadochokinesis (HP:0002075)3.22872569
26Anxiety (HP:0000739)3.16084766
27Urinary bladder sphincter dysfunction (HP:0002839)3.13316797
28Truncal ataxia (HP:0002078)3.05504775
29Amblyopia (HP:0000646)3.03915303
30Postural instability (HP:0002172)3.02641386
31Abnormality of the lower motor neuron (HP:0002366)3.00093123
32Mutism (HP:0002300)2.98936857
33Abnormal eating behavior (HP:0100738)2.95376060
34Tetraplegia (HP:0002445)2.80006986
35Urinary urgency (HP:0000012)2.77335592
36Torticollis (HP:0000473)2.77193619
37Genetic anticipation (HP:0003743)2.75913521
38Excessive salivation (HP:0003781)2.68578429
39Drooling (HP:0002307)2.68578429
40Impaired smooth pursuit (HP:0007772)2.68353791
41Spastic gait (HP:0002064)2.68218313
42Scanning speech (HP:0002168)2.67698296
43Focal dystonia (HP:0004373)2.66056889
44Intention tremor (HP:0002080)2.65681469
45Stereotypic behavior (HP:0000733)2.62433155
46Neurofibrillary tangles (HP:0002185)2.61808239
47Progressive inability to walk (HP:0002505)2.61657207
48Akinesia (HP:0002304)2.61180756
49Cerebral inclusion bodies (HP:0100314)2.61075939
50Insidious onset (HP:0003587)2.59220259
51Termporal pattern (HP:0011008)2.59220259
52Bradykinesia (HP:0002067)2.54184219
53Epileptiform EEG discharges (HP:0011182)2.53357849
54Hemiparesis (HP:0001269)2.49794193
55Abnormality of binocular vision (HP:0011514)2.49611481
56Diplopia (HP:0000651)2.49611481
57Megalencephaly (HP:0001355)2.48966015
58Ventricular fibrillation (HP:0001663)2.48294260
59Annular pancreas (HP:0001734)2.47066238
60Dysmetric saccades (HP:0000641)2.43988832
61Impaired vibratory sensation (HP:0002495)2.42640244
62EEG with generalized epileptiform discharges (HP:0011198)2.40129849
63Pheochromocytoma (HP:0002666)2.39415106
64Hemiplegia (HP:0002301)2.37223393
65Cerebral hypomyelination (HP:0006808)2.35919245
66Abnormality of ocular smooth pursuit (HP:0000617)2.33929568
67Abnormality of the corticospinal tract (HP:0002492)2.32279836
68Craniofacial dystonia (HP:0012179)2.30949599
69Hypsarrhythmia (HP:0002521)2.29694649
70Absent speech (HP:0001344)2.25827650
71Ocular albinism (HP:0001107)2.23377991
72Status epilepticus (HP:0002133)2.20801865
73Lower limb muscle weakness (HP:0007340)2.19468476
74Obstructive sleep apnea (HP:0002870)2.17929308
75Fetal akinesia sequence (HP:0001989)2.13843448
76Bundle branch block (HP:0011710)2.13581774
77Generalized myoclonic seizures (HP:0002123)2.09822386
78Iris hypopigmentation (HP:0007730)2.08237314
79Inability to walk (HP:0002540)2.07052616
80Pointed chin (HP:0000307)2.05137055
81Neuroendocrine neoplasm (HP:0100634)2.01978790
82Incomplete penetrance (HP:0003829)2.01090230
83Spastic tetraparesis (HP:0001285)1.99992457
84Amyotrophic lateral sclerosis (HP:0007354)1.99267173
85Increased circulating renin level (HP:0000848)1.98583592
86Agitation (HP:0000713)1.98461185
87Gait ataxia (HP:0002066)1.97913375
88Limb dystonia (HP:0002451)1.97248096
89Diminished motivation (HP:0000745)1.94833982
90Lower limb asymmetry (HP:0100559)1.94485422
91Polyphagia (HP:0002591)1.92249519
92Insomnia (HP:0100785)1.91584023
93Sleep apnea (HP:0010535)1.91097149
94Rapidly progressive (HP:0003678)1.90327651
95Peripheral hypomyelination (HP:0007182)1.90185279
96Clonus (HP:0002169)1.89517484
97Abnormal EKG (HP:0003115)1.88197158
98Blue irides (HP:0000635)1.87610275
99Resting tremor (HP:0002322)1.87448350
100Postural tremor (HP:0002174)1.85347972
101Rigidity (HP:0002063)1.84810427
102Choreoathetosis (HP:0001266)1.83947814
103Psychosis (HP:0000709)1.83574144
104Inappropriate behavior (HP:0000719)1.82237698
105Abnormality of salivation (HP:0100755)1.81957354
106Delusions (HP:0000746)1.81636373
107Neuronal loss in central nervous system (HP:0002529)1.81004005
108Abnormality of saccadic eye movements (HP:0000570)1.80569944
109Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.79389930
110Lower limb amyotrophy (HP:0007210)1.77841389
111Ankyloglossia (HP:0010296)1.76377461
112Apathy (HP:0000741)1.76122428
113Slow saccadic eye movements (HP:0000514)1.75741522
114Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.74808351
115Degeneration of the lateral corticospinal tracts (HP:0002314)1.74808351
116Thickened helices (HP:0000391)1.74139188
117Heart block (HP:0012722)1.68990588
118Spinal canal stenosis (HP:0003416)1.68285309
119Limb ataxia (HP:0002070)1.68254877
120Slow progression (HP:0003677)1.67550803

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.67887432
2EPHA44.53083634
3MAP3K93.95589129
4MARK12.93164133
5MAP3K42.74865388
6MINK12.73711490
7DAPK22.61093736
8KSR22.48320252
9PRKD32.31431178
10MAP2K72.24400070
11PAK62.24026027
12RIPK42.02811439
13CAMKK11.98595966
14NTRK11.87414864
15NTRK21.81449137
16MAP2K41.81005022
17MAP3K121.77100708
18KSR11.69116430
19DAPK11.64709119
20CASK1.62680177
21CDK51.59913456
22ARAF1.55484776
23PRPF4B1.54231662
24MAP3K21.45190607
25MAP3K131.40911548
26GRK51.39388167
27CDK191.36927838
28PLK21.33095639
29STK381.30934134
30TNIK1.29533060
31FES1.28898340
32MAPK131.23938683
33SIK21.22857940
34PRKCG1.21225530
35PNCK1.12003983
36CAMKK21.09501077
37PHKG21.07255328
38PHKG11.07255328
39CAMK11.06413653
40UHMK11.02925365
41TYRO31.02780218
42CAMK2A0.99370778
43PTK2B0.97386392
44TAOK10.97364694
45SGK4940.95777153
46SGK2230.95777153
47RAF10.95548201
48RET0.91878853
49CDK180.89619994
50STK110.89387494
51PRKCH0.89200126
52LATS20.88594702
53CDK150.88151707
54CAMK2B0.87839297
55CDK140.87730413
56LMTK20.83075434
57SGK20.81852434
58OXSR10.76988531
59SGK30.76811184
60CDK11A0.76785500
61PAK30.76461644
62BMPR20.72891898
63MAP3K10.72695910
64MARK20.72474381
65PINK10.71623084
66SGK10.69586768
67AKT30.69548491
68ALK0.68978792
69DYRK1A0.64416669
70FRK0.63455292
71* PDK10.60811184
72MAP3K70.59401251
73JAK10.58423687
74FGFR20.57906747
75CSNK1G20.56357859
76CAMK1G0.53197807
77MOS0.52360574
78PRKCZ0.51421057
79MAP2K10.51129087
80ROCK20.50928827
81NME10.50569591
82CAMK40.50537622
83DMPK0.49688812
84RPS6KA30.49408755
85PKN10.49014311
86CAMK2D0.48653080
87FER0.47822519
88* PDPK10.47787268
89FYN0.47435092
90TNK20.44534906
91RIPK10.44160967
92EEF2K0.43261011
93NEK60.42946627
94CAMK2G0.42290079
95CDC42BPA0.41395124
96MAPK100.40609503
97WNK10.40390075
98SCYL20.39786796
99ROCK10.39736954
100DAPK30.38172444
101FGR0.38055798
102MAPK120.37311883
103CCNB10.36090983
104RPS6KA20.35504271
105JAK20.35141029
106MAPK70.34472570
107PDK20.33598595
108IRAK20.32856124
109NEK10.32270907
110PRKG10.32112558
111MAP2K60.31231381
112MAP3K60.30820546
113BRAF0.30479947
114* PRKCE0.30428647
115PRKCB0.29948009
116BRSK10.29773335
117STK390.29522971
118PRKAA10.28218303

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.45062886
2Synaptic vesicle cycle_Homo sapiens_hsa047213.16441373
3Long-term potentiation_Homo sapiens_hsa047202.83489375
4Olfactory transduction_Homo sapiens_hsa047402.80394104
5Circadian entrainment_Homo sapiens_hsa047132.76875703
6Glutamatergic synapse_Homo sapiens_hsa047242.62386153
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.61606358
8GABAergic synapse_Homo sapiens_hsa047272.57022897
9Amphetamine addiction_Homo sapiens_hsa050312.50785324
10Morphine addiction_Homo sapiens_hsa050322.42923497
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.31237728
12Salivary secretion_Homo sapiens_hsa049702.22767008
13Dopaminergic synapse_Homo sapiens_hsa047282.17202890
14Insulin secretion_Homo sapiens_hsa049112.07656252
15Cholinergic synapse_Homo sapiens_hsa047251.97606073
16Gastric acid secretion_Homo sapiens_hsa049711.94479294
17* Aldosterone synthesis and secretion_Homo sapiens_hsa049251.83410180
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72748260
19Long-term depression_Homo sapiens_hsa047301.71524169
20Oxytocin signaling pathway_Homo sapiens_hsa049211.69356689
21Renin secretion_Homo sapiens_hsa049241.69254553
22Taste transduction_Homo sapiens_hsa047421.63992322
23Calcium signaling pathway_Homo sapiens_hsa040201.62791490
24Serotonergic synapse_Homo sapiens_hsa047261.55630407
25Cocaine addiction_Homo sapiens_hsa050301.53681400
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.52840463
27GnRH signaling pathway_Homo sapiens_hsa049121.50740727
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.42151512
29Gap junction_Homo sapiens_hsa045401.34873659
30cAMP signaling pathway_Homo sapiens_hsa040241.29612686
31Collecting duct acid secretion_Homo sapiens_hsa049661.26531377
32Glioma_Homo sapiens_hsa052141.26067970
33* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24280169
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20887257
35Nitrogen metabolism_Homo sapiens_hsa009101.18156218
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17192183
37Estrogen signaling pathway_Homo sapiens_hsa049151.16597918
38ErbB signaling pathway_Homo sapiens_hsa040121.08633870
39Axon guidance_Homo sapiens_hsa043601.07504609
40* Type II diabetes mellitus_Homo sapiens_hsa049301.06622415
41Melanogenesis_Homo sapiens_hsa049161.05855198
42* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04268427
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00227499
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91543372
45Vitamin B6 metabolism_Homo sapiens_hsa007500.90928304
46Pancreatic secretion_Homo sapiens_hsa049720.90038696
47Phospholipase D signaling pathway_Homo sapiens_hsa040720.89536783
48* Vascular smooth muscle contraction_Homo sapiens_hsa042700.89536199
49Cardiac muscle contraction_Homo sapiens_hsa042600.89440185
50Dorso-ventral axis formation_Homo sapiens_hsa043200.89326422
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88680912
52Oocyte meiosis_Homo sapiens_hsa041140.84496195
53Thyroid hormone synthesis_Homo sapiens_hsa049180.81603822
54Vibrio cholerae infection_Homo sapiens_hsa051100.81243542
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80736150
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80656077
57Choline metabolism in cancer_Homo sapiens_hsa052310.78714937
58VEGF signaling pathway_Homo sapiens_hsa043700.75251744
59Dilated cardiomyopathy_Homo sapiens_hsa054140.72371733
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71520264
61MAPK signaling pathway_Homo sapiens_hsa040100.70903738
62Phototransduction_Homo sapiens_hsa047440.70628395
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.70226617
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69754563
65Glucagon signaling pathway_Homo sapiens_hsa049220.65145733
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63912464
67Ras signaling pathway_Homo sapiens_hsa040140.60459553
68Rap1 signaling pathway_Homo sapiens_hsa040150.59186390
69mTOR signaling pathway_Homo sapiens_hsa041500.57601898
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56208596
71Endocytosis_Homo sapiens_hsa041440.53487110
72Non-small cell lung cancer_Homo sapiens_hsa052230.51693168
73Bile secretion_Homo sapiens_hsa049760.50983853
74Inositol phosphate metabolism_Homo sapiens_hsa005620.50898072
75Fatty acid biosynthesis_Homo sapiens_hsa000610.49912395
76* Sphingolipid signaling pathway_Homo sapiens_hsa040710.49795859
77B cell receptor signaling pathway_Homo sapiens_hsa046620.47143671
78African trypanosomiasis_Homo sapiens_hsa051430.46057786
79Endometrial cancer_Homo sapiens_hsa052130.44846702
80Prion diseases_Homo sapiens_hsa050200.44204273
81Renal cell carcinoma_Homo sapiens_hsa052110.43916580
82Type I diabetes mellitus_Homo sapiens_hsa049400.42999509
83Insulin signaling pathway_Homo sapiens_hsa049100.42467218
84Alcoholism_Homo sapiens_hsa050340.42317488
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41921592
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40921741
87Circadian rhythm_Homo sapiens_hsa047100.40640293
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40044516
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39416545
90Wnt signaling pathway_Homo sapiens_hsa043100.38542825
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38307822
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37563960
93Chemokine signaling pathway_Homo sapiens_hsa040620.36183730
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36059279
95ABC transporters_Homo sapiens_hsa020100.34330993
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33494312
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32824785
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32521621
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31966271
100* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.30725402
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30430119
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30354862
103Mineral absorption_Homo sapiens_hsa049780.30196307
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29870682
105* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29615589
106Arginine biosynthesis_Homo sapiens_hsa002200.28976368
107Ovarian steroidogenesis_Homo sapiens_hsa049130.28456074
108Alzheimers disease_Homo sapiens_hsa050100.27796694
109HIF-1 signaling pathway_Homo sapiens_hsa040660.27477287
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.27438898
111Platelet activation_Homo sapiens_hsa046110.26737812
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.26041503

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