PRKCG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.75255350
2locomotory exploration behavior (GO:0035641)6.72193081
3regulation of short-term neuronal synaptic plasticity (GO:0048172)6.63807686
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.35833781
5synaptic vesicle docking involved in exocytosis (GO:0016081)5.93475243
6synaptic vesicle exocytosis (GO:0016079)5.91156281
7glutamate secretion (GO:0014047)5.87130028
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.76591151
9vocalization behavior (GO:0071625)5.73619256
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.69069442
11ionotropic glutamate receptor signaling pathway (GO:0035235)5.58345546
12regulation of glutamate receptor signaling pathway (GO:1900449)5.37098662
13regulation of synaptic vesicle exocytosis (GO:2000300)5.30050423
14neuronal action potential propagation (GO:0019227)5.12276338
15synaptic transmission, glutamatergic (GO:0035249)4.99814534
16regulation of neuronal synaptic plasticity (GO:0048168)4.99549592
17exploration behavior (GO:0035640)4.93324426
18regulation of long-term neuronal synaptic plasticity (GO:0048169)4.91906426
19glutamate receptor signaling pathway (GO:0007215)4.81740271
20regulation of synaptic vesicle transport (GO:1902803)4.80781876
21protein localization to synapse (GO:0035418)4.75218598
22neurotransmitter secretion (GO:0007269)4.69520157
23long-term memory (GO:0007616)4.60948339
24regulation of synapse structural plasticity (GO:0051823)4.41157935
25neurotransmitter-gated ion channel clustering (GO:0072578)4.40394810
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.40229229
27neuron-neuron synaptic transmission (GO:0007270)4.39564295
28regulation of excitatory postsynaptic membrane potential (GO:0060079)4.36256303
29cellular potassium ion homeostasis (GO:0030007)4.27609784
30positive regulation of membrane potential (GO:0045838)4.23062047
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.21374306
32dendritic spine morphogenesis (GO:0060997)4.20139283
33regulation of synaptic plasticity (GO:0048167)4.12038827
34cell differentiation in hindbrain (GO:0021533)4.10743609
35regulation of postsynaptic membrane potential (GO:0060078)4.05954342
36positive regulation of synapse maturation (GO:0090129)4.05667425
37sodium ion export (GO:0071436)4.05631007
38gamma-aminobutyric acid transport (GO:0015812)4.01492912
39neuron cell-cell adhesion (GO:0007158)3.93312110
40layer formation in cerebral cortex (GO:0021819)3.91740162
41proline transport (GO:0015824)3.88386484
42cerebellar Purkinje cell layer development (GO:0021680)3.87309106
43potassium ion homeostasis (GO:0055075)3.86677310
44short-term memory (GO:0007614)3.85306684
45long-term synaptic potentiation (GO:0060291)3.83141795
46regulation of dendritic spine morphogenesis (GO:0061001)3.81454647
47cerebellar Purkinje cell differentiation (GO:0021702)3.81181422
48amino acid import (GO:0043090)3.76795329
49synaptic vesicle endocytosis (GO:0048488)3.76523064
50positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.75834731
51axon ensheathment in central nervous system (GO:0032291)3.71083379
52central nervous system myelination (GO:0022010)3.71083379
53cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.70311633
54activation of protein kinase A activity (GO:0034199)3.69370163
55neuromuscular process controlling balance (GO:0050885)3.67136650
56neurotransmitter transport (GO:0006836)3.67095104
57regulation of neurotransmitter secretion (GO:0046928)3.65097451
58regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.64026502
59negative regulation of dendrite morphogenesis (GO:0050774)3.59371306
60neuromuscular process controlling posture (GO:0050884)3.56729539
61G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.55022267
62cerebellar granule cell differentiation (GO:0021707)3.52227229
63gamma-aminobutyric acid signaling pathway (GO:0007214)3.51855269
64L-amino acid import (GO:0043092)3.50846277
65potassium ion import (GO:0010107)3.49479993
66cell communication by electrical coupling (GO:0010644)3.46891077
67acidic amino acid transport (GO:0015800)3.46681345
68regulation of neurotransmitter levels (GO:0001505)3.46070602
69dendritic spine organization (GO:0097061)3.45467749
70behavioral fear response (GO:0001662)3.44651829
71behavioral defense response (GO:0002209)3.44651829
72neuromuscular synaptic transmission (GO:0007274)3.44342314
73G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.44110028
74regulation of vesicle fusion (GO:0031338)3.44059982
75positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.43764407
76regulation of synaptic transmission, glutamatergic (GO:0051966)3.42004549
77membrane depolarization (GO:0051899)3.41930437
78presynaptic membrane organization (GO:0097090)3.37978540
79regulation of neurotransmitter transport (GO:0051588)3.35140206
80positive regulation of neurotransmitter secretion (GO:0001956)3.34182963
81transmission of nerve impulse (GO:0019226)3.32601136
82long term synaptic depression (GO:0060292)3.32553970
83neurofilament cytoskeleton organization (GO:0060052)3.32326129
84negative regulation of synaptic transmission, GABAergic (GO:0032229)3.28565488
85adult walking behavior (GO:0007628)3.26311212
86membrane depolarization during action potential (GO:0086010)3.25938284
87regulation of synaptic transmission (GO:0050804)3.25144634
88regulation of ARF protein signal transduction (GO:0032012)3.24065225
89fear response (GO:0042596)3.22428052
90learning (GO:0007612)3.21527000
91positive regulation of dendritic spine morphogenesis (GO:0061003)3.18337023
92positive regulation of synaptic transmission (GO:0050806)3.18258923
93regulation of dendritic spine development (GO:0060998)3.17957497
94positive regulation of dendritic spine development (GO:0060999)3.17831484
95auditory behavior (GO:0031223)3.17423643
96positive regulation of neurotransmitter transport (GO:0051590)3.16932367
97behavioral response to cocaine (GO:0048148)3.16301179
98positive regulation of synaptic transmission, GABAergic (GO:0032230)3.14306418
99neuromuscular process (GO:0050905)3.13291737
100positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.12820960
101regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.12754362
102regulation of calcium ion-dependent exocytosis (GO:0017158)3.11849426
103neuron recognition (GO:0008038)3.11757141
104serotonin metabolic process (GO:0042428)3.11627484
105L-glutamate transport (GO:0015813)3.11524861
106regulation of synapse maturation (GO:0090128)3.10460206
107* synaptic transmission (GO:0007268)3.08349521
108prepulse inhibition (GO:0060134)3.06597896
109C4-dicarboxylate transport (GO:0015740)3.06573840
110regulation of voltage-gated calcium channel activity (GO:1901385)3.04746760
111cellular sodium ion homeostasis (GO:0006883)3.03515052
112vesicle transport along microtubule (GO:0047496)3.03068076
113axonal fasciculation (GO:0007413)3.02290868
114glycine transport (GO:0015816)3.02215354
115membrane hyperpolarization (GO:0060081)3.02022496
116establishment of synaptic vesicle localization (GO:0097480)3.01366842
117response to auditory stimulus (GO:0010996)3.00985777
118neuronal ion channel clustering (GO:0045161)3.00825136
119dendrite morphogenesis (GO:0048813)3.00094922
120postsynaptic membrane organization (GO:0001941)2.98708725
121intraspecies interaction between organisms (GO:0051703)2.97683529

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.41103581
2GBX2_23144817_ChIP-Seq_PC3_Human3.34585388
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.20274392
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.17052540
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.13563198
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.94817005
7REST_21632747_ChIP-Seq_MESCs_Mouse2.91992293
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.85513085
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.85513085
10DROSHA_22980978_ChIP-Seq_HELA_Human2.84686467
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.71400074
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.67222693
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.61607248
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.58093849
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.57299587
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49486776
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.42864272
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.39653231
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.37990607
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.29212717
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.29117501
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.27476173
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.27202737
24* IKZF1_21737484_ChIP-ChIP_HCT116_Human2.20850915
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.17085009
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01490725
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90532636
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85290220
29AR_21572438_ChIP-Seq_LNCaP_Human1.71019288
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.68775359
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68598072
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59082982
33SMAD4_21799915_ChIP-Seq_A2780_Human1.57894674
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54747033
35RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.45302298
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43334472
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.42700424
38GATA1_26923725_Chip-Seq_HPCs_Mouse1.36418028
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.32643015
40ZNF274_21170338_ChIP-Seq_K562_Hela1.29570161
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27414933
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.26602957
43AR_19668381_ChIP-Seq_PC3_Human1.26150655
44SOX2_21211035_ChIP-Seq_LN229_Gbm1.26004311
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24268129
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23823484
47NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23253637
48ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22511466
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21832961
50WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21676967
51AR_25329375_ChIP-Seq_VCAP_Human1.21026675
52KDM2B_26808549_Chip-Seq_K562_Human1.20742699
53* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19414458
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18732406
55RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.17994015
56SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17833564
57ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17782896
58GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17478578
59WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16369498
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.16180382
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15098346
62P300_19829295_ChIP-Seq_ESCs_Human1.14522531
63STAT3_23295773_ChIP-Seq_U87_Human1.13708616
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12511175
65RING1B_27294783_Chip-Seq_NPCs_Mouse1.08619902
66RXR_22108803_ChIP-Seq_LS180_Human1.08312618
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08156483
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07553136
69TAF15_26573619_Chip-Seq_HEK293_Human1.07282169
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06999425
71P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06899869
72SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.05761362
73OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.05720167
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04352782
75TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03159463
76TP53_16413492_ChIP-PET_HCT116_Human1.02296319
77SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01663879
78CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00603702
79* TCF4_23295773_ChIP-Seq_U87_Human0.99700682
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99568186
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99568186
82YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99428119
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98553159
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98048874
85SMAD3_21741376_ChIP-Seq_HESCs_Human0.97949991
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97576782
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96874121
88TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96139052
89PIAS1_25552417_ChIP-Seq_VCAP_Human0.94418937
90CBX2_27304074_Chip-Seq_ESCs_Mouse0.94322908
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94038501
92SMAD3_21741376_ChIP-Seq_ESCs_Human0.93943957
93ARNT_22903824_ChIP-Seq_MCF-7_Human0.93283653
94NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93080380
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92602353
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92353243
97SMAD4_21741376_ChIP-Seq_HESCs_Human0.92172491
98ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91344598
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90814555
100TET1_21490601_ChIP-Seq_MESCs_Mouse0.90456856
101SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90150919
102PRDM14_20953172_ChIP-Seq_ESCs_Human0.89842652
103SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87909020
104OCT4_19829295_ChIP-Seq_ESCs_Human0.87397289
105AHR_22903824_ChIP-Seq_MCF-7_Human0.86703638
106TP53_20018659_ChIP-ChIP_R1E_Mouse0.86104300
107DPY_21335234_ChIP-Seq_ESCs_Mouse0.84635824
108TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84379653
109RUNX2_22187159_ChIP-Seq_PCA_Human0.84041298
110TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83925171
111FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.83403606
112SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.82520826
113CTCF_27219007_Chip-Seq_Bcells_Human0.81967908
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81838763
115SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81796776
116RNF2_27304074_Chip-Seq_NSC_Mouse0.80210978
117IGF1R_20145208_ChIP-Seq_DFB_Human0.80173400
118RUNX1_26923725_Chip-Seq_HPCs_Mouse0.79395131
119LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78747940
120KLF4_19829295_ChIP-Seq_ESCs_Human0.78678849
121PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.77430900
122PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.74919733

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity8.11208383
2MP0003880_abnormal_central_pattern4.68485377
3MP0003635_abnormal_synaptic_transmissio4.59138683
4MP0004270_analgesia3.86545765
5MP0009745_abnormal_behavioral_response3.64968780
6MP0002063_abnormal_learning/memory/cond3.63708543
7MP0002064_seizures3.46974424
8MP0009046_muscle_twitch3.46752186
9MP0002572_abnormal_emotion/affect_behav2.97754620
10MP0001968_abnormal_touch/_nociception2.90940708
11MP0002272_abnormal_nervous_system2.78046133
12MP0001486_abnormal_startle_reflex2.61174011
13MP0002822_catalepsy2.60493173
14MP0002734_abnormal_mechanical_nocicepti2.55973606
15MP0005423_abnormal_somatic_nervous2.50983130
16MP0001501_abnormal_sleep_pattern2.42306587
17MP0008569_lethality_at_weaning2.32549130
18MP0002736_abnormal_nociception_after2.26375000
19MP0002735_abnormal_chemical_nociception2.21797443
20MP0001440_abnormal_grooming_behavior2.17546998
21MP0002067_abnormal_sensory_capabilities1.94776504
22MP0009780_abnormal_chondrocyte_physiolo1.92447818
23MP0001970_abnormal_pain_threshold1.86938137
24MP0004811_abnormal_neuron_physiology1.84402887
25MP0004858_abnormal_nervous_system1.83775115
26MP0003879_abnormal_hair_cell1.79798876
27MP0002733_abnormal_thermal_nociception1.79081404
28MP0003123_paternal_imprinting1.76371868
29MP0002184_abnormal_innervation1.70518694
30MP0002557_abnormal_social/conspecific_i1.69845337
31MP0003329_amyloid_beta_deposits1.69241838
32MP0002909_abnormal_adrenal_gland1.63209976
33MP0003787_abnormal_imprinting1.63149934
34MP0005386_behavior/neurological_phenoty1.62740723
35MP0004924_abnormal_behavior1.62740723
36MP0005646_abnormal_pituitary_gland1.60227249
37MP0000778_abnormal_nervous_system1.51667357
38MP0003633_abnormal_nervous_system1.49695264
39MP0004885_abnormal_endolymph1.47682032
40MP0000955_abnormal_spinal_cord1.46306892
41MP0002066_abnormal_motor_capabilities/c1.46020263
42MP0001984_abnormal_olfaction1.35925450
43MP0002882_abnormal_neuron_morphology1.34554455
44MP0002638_abnormal_pupillary_reflex1.27224348
45MP0003631_nervous_system_phenotype1.25962067
46MP0003075_altered_response_to1.25937270
47MP0008877_abnormal_DNA_methylation1.24932927
48MP0008872_abnormal_physiological_respon1.17064784
49MP0004142_abnormal_muscle_tone1.14665967
50MP0001502_abnormal_circadian_rhythm1.12210155
51MP0002152_abnormal_brain_morphology1.07914216
52MP0005645_abnormal_hypothalamus_physiol1.06305306
53MP0004145_abnormal_muscle_electrophysio1.04734093
54MP0001905_abnormal_dopamine_level1.04459910
55MP0008874_decreased_physiological_sensi1.02906549
56MP0000751_myopathy1.00475642
57MP0002069_abnormal_eating/drinking_beha0.96117600
58MP0004510_myositis0.94909368
59MP0005167_abnormal_blood-brain_barrier0.94114246
60MP0001177_atelectasis0.93888743
61MP0003121_genomic_imprinting0.93886132
62MP0003690_abnormal_glial_cell0.92228153
63MP0006276_abnormal_autonomic_nervous0.90055594
64MP0003632_abnormal_nervous_system0.89856352
65MP0003122_maternal_imprinting0.87996193
66MP0004484_altered_response_of0.84801303
67MP0001986_abnormal_taste_sensitivity0.84559105
68MP0001529_abnormal_vocalization0.84237880
69MP0004215_abnormal_myocardial_fiber0.84039430
70MP0002229_neurodegeneration0.83698844
71MP0003283_abnormal_digestive_organ0.83111731
72MP0005535_abnormal_body_temperature0.81414698
73MP0004085_abnormal_heartbeat0.80471285
74MP0000569_abnormal_digit_pigmentation0.80438607
75MP0000920_abnormal_myelination0.79236566
76MP0008961_abnormal_basal_metabolism0.77894277
77MP0004742_abnormal_vestibular_system0.77076883
78MP0001963_abnormal_hearing_physiology0.76815916
79MP0000604_amyloidosis0.73781797
80MP0000566_synostosis0.73440853
81MP0003634_abnormal_glial_cell0.71282382
82MP0001188_hyperpigmentation0.71222129
83MP0001346_abnormal_lacrimal_gland0.70734157
84MP0006292_abnormal_olfactory_placode0.69865585
85MP0000013_abnormal_adipose_tissue0.69644762
86MP0005410_abnormal_fertilization0.69337752
87MP0004147_increased_porphyrin_level0.69080278
88MP0004043_abnormal_pH_regulation0.67693715
89MP0010386_abnormal_urinary_bladder0.67182656
90MP0005623_abnormal_meninges_morphology0.65648821
91MP0003861_abnormal_nervous_system0.65472036
92MP0005551_abnormal_eye_electrophysiolog0.64875908
93MP0002090_abnormal_vision0.64207035
94MP0005394_taste/olfaction_phenotype0.64180044
95MP0005499_abnormal_olfactory_system0.64180044
96MP0004233_abnormal_muscle_weight0.62657647
97MP0003646_muscle_fatigue0.62598929
98MP0000026_abnormal_inner_ear0.61356802
99MP0003137_abnormal_impulse_conducting0.61164630
100MP0001485_abnormal_pinna_reflex0.59517327
101MP0010234_abnormal_vibrissa_follicle0.58783980
102MP0002653_abnormal_ependyma_morphology0.58452343
103MP0001664_abnormal_digestion0.57691757
104MP0001348_abnormal_lacrimal_gland0.57227509
105MP0002752_abnormal_somatic_nervous0.54247216
106MP0010769_abnormal_survival0.53919154
107MP0003172_abnormal_lysosome_physiology0.52930324
108MP0006035_abnormal_mitochondrial_morpho0.52677709
109MP0005166_decreased_susceptibility_to0.52404205
110MP0002089_abnormal_postnatal_growth/wei0.51581502
111MP0000631_abnormal_neuroendocrine_gland0.50843887
112MP0001299_abnormal_eye_distance/0.50782540
113MP0003956_abnormal_body_size0.50745978
114MP0010768_mortality/aging0.50616485
115MP0010770_preweaning_lethality0.48799874
116MP0002082_postnatal_lethality0.48799874
117MP0001943_abnormal_respiration0.48258632
118MP0003938_abnormal_ear_development0.47235932
119MP0009379_abnormal_foot_pigmentation0.45364122

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.82977691
2* Myokymia (HP:0002411)7.01896734
3Focal seizures (HP:0007359)6.45071790
4Visual hallucinations (HP:0002367)5.86781771
5Epileptic encephalopathy (HP:0200134)5.34039113
6Action tremor (HP:0002345)4.98585452
7Febrile seizures (HP:0002373)4.87134393
8Atonic seizures (HP:0010819)4.86805617
9Absence seizures (HP:0002121)4.45714463
10Gaze-evoked nystagmus (HP:0000640)4.34823771
11* Progressive cerebellar ataxia (HP:0002073)4.22360542
12Generalized tonic-clonic seizures (HP:0002069)4.16874614
13Dialeptic seizures (HP:0011146)4.09630723
14Broad-based gait (HP:0002136)3.91934976
15Dysdiadochokinesis (HP:0002075)3.86881809
16Limb dystonia (HP:0002451)3.85882686
17Poor eye contact (HP:0000817)3.70516768
18Abnormality of the lower motor neuron (HP:0002366)3.50856515
19Impaired smooth pursuit (HP:0007772)3.47909130
20Postural instability (HP:0002172)3.44000543
21* Dysmetria (HP:0001310)3.42436441
22Abnormal social behavior (HP:0012433)3.31592150
23Impaired social interactions (HP:0000735)3.31592150
24Genetic anticipation (HP:0003743)3.31182160
25Dysmetric saccades (HP:0000641)3.29380140
26Supranuclear gaze palsy (HP:0000605)3.24406218
27Ankle clonus (HP:0011448)3.21433970
28Anxiety (HP:0000739)3.18438923
29Truncal ataxia (HP:0002078)3.18243471
30Urinary bladder sphincter dysfunction (HP:0002839)3.15433082
31Annular pancreas (HP:0001734)3.15026692
32Scanning speech (HP:0002168)3.13843705
33Hemiplegia (HP:0002301)3.11947367
34Abnormal eating behavior (HP:0100738)3.11917169
35Abnormality of ocular smooth pursuit (HP:0000617)3.09064201
36* Depression (HP:0000716)3.08868873
37Hyperventilation (HP:0002883)3.07999657
38Intention tremor (HP:0002080)3.06216973
39Ventricular fibrillation (HP:0001663)3.04359180
40Cerebral hypomyelination (HP:0006808)3.01233744
41Amblyopia (HP:0000646)3.01140808
42Papilledema (HP:0001085)2.90548305
43Mutism (HP:0002300)2.88176854
44Torticollis (HP:0000473)2.84524182
45Stereotypic behavior (HP:0000733)2.80889791
46Degeneration of the lateral corticospinal tracts (HP:0002314)2.80833540
47Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.80833540
48* Impaired vibration sensation in the lower limbs (HP:0002166)2.78464169
49Abnormality of binocular vision (HP:0011514)2.73499798
50Diplopia (HP:0000651)2.73499798
51Bundle branch block (HP:0011710)2.67607269
52Bradykinesia (HP:0002067)2.66101089
53Hemiparesis (HP:0001269)2.63754672
54Urinary urgency (HP:0000012)2.60485775
55Status epilepticus (HP:0002133)2.59308235
56Sleep apnea (HP:0010535)2.57995119
57Epileptiform EEG discharges (HP:0011182)2.54016687
58Megalencephaly (HP:0001355)2.52622031
59Drooling (HP:0002307)2.51800949
60Excessive salivation (HP:0003781)2.51800949
61Spastic gait (HP:0002064)2.48360814
62Pointed chin (HP:0000307)2.42015265
63Akinesia (HP:0002304)2.36198748
64Polyphagia (HP:0002591)2.32875086
65Craniofacial dystonia (HP:0012179)2.31869151
66Apathy (HP:0000741)2.30443154
67Absent speech (HP:0001344)2.29330694
68EEG with generalized epileptiform discharges (HP:0011198)2.28154436
69Fetal akinesia sequence (HP:0001989)2.28144849
70Progressive inability to walk (HP:0002505)2.26802459
71* Focal dystonia (HP:0004373)2.25902496
72Abnormality of saccadic eye movements (HP:0000570)2.24859743
73Obstructive sleep apnea (HP:0002870)2.22819513
74Morphological abnormality of the pyramidal tract (HP:0002062)2.22269203
75Lower limb asymmetry (HP:0100559)2.19146544
76Generalized myoclonic seizures (HP:0002123)2.18911262
77Hypsarrhythmia (HP:0002521)2.17867280
78Peripheral hypomyelination (HP:0007182)2.15198486
79* Impaired vibratory sensation (HP:0002495)2.13782356
80Diminished motivation (HP:0000745)2.09234970
81* Incomplete penetrance (HP:0003829)2.07207598
82Tetraplegia (HP:0002445)2.05417010
83Choreoathetosis (HP:0001266)2.02532293
84Spinal canal stenosis (HP:0003416)1.99646953
85CNS hypomyelination (HP:0003429)1.98443657
86* Gait ataxia (HP:0002066)1.96513764
87Limb ataxia (HP:0002070)1.96277758
88Rigidity (HP:0002063)1.92558988
89Abnormal EKG (HP:0003115)1.91689800
90Lower limb muscle weakness (HP:0007340)1.90094165
91Abnormality of the periventricular white matter (HP:0002518)1.88652460
92Cerebral inclusion bodies (HP:0100314)1.87339356
93Delusions (HP:0000746)1.87332001
94Abnormality of the corticospinal tract (HP:0002492)1.85649439
95Inability to walk (HP:0002540)1.84920574
96Horizontal nystagmus (HP:0000666)1.84748066
97Psychosis (HP:0000709)1.83854468
98Neurofibrillary tangles (HP:0002185)1.83461141
99Neuronal loss in central nervous system (HP:0002529)1.82263364
100Spastic tetraplegia (HP:0002510)1.81524142
101Insidious onset (HP:0003587)1.81311373
102Termporal pattern (HP:0011008)1.81311373
103Clonus (HP:0002169)1.80406344
104Insomnia (HP:0100785)1.80373998
105Agitation (HP:0000713)1.80043710
106Resting tremor (HP:0002322)1.75500613
107Aplasia of the phalanges of the hand (HP:0009802)1.75137480
108Aplasia involving bones of the extremities (HP:0009825)1.75137480
109Aplasia involving bones of the upper limbs (HP:0009823)1.75137480
110Blue irides (HP:0000635)1.73874373
111Intellectual disability, profound (HP:0002187)1.72430667
112Ankyloglossia (HP:0010296)1.72195277
113Amyotrophic lateral sclerosis (HP:0007354)1.71590617
114Abnormality of salivation (HP:0100755)1.68955864
115Spastic tetraparesis (HP:0001285)1.68032861
116Rapidly progressive (HP:0003678)1.67267755
117Increased circulating renin level (HP:0000848)1.67228239
118Unsteady gait (HP:0002317)1.67066816
119Postural tremor (HP:0002174)1.65889370
120* Dysarthria (HP:0001260)1.65172341
121Hand muscle atrophy (HP:0009130)1.63463276
122Lower limb amyotrophy (HP:0007210)1.63276529

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.80277531
2EPHA44.47859802
3MAP3K93.70157848
4DAPK22.86450648
5MAP3K42.81509097
6MINK12.68808938
7PAK62.56167497
8PRKD32.54898394
9CAMKK12.33655110
10MAP2K72.32086468
11KSR22.24741789
12RIPK42.09847656
13DAPK12.09578642
14MAP3K121.98364739
15CDK191.97777218
16PRPF4B1.93749441
17MARK11.88380135
18MAP2K41.87110421
19NTRK21.75839210
20KSR11.75228647
21STK381.70021200
22CDK51.60822665
23CAMKK21.54408775
24PLK21.44746300
25NTRK11.44204104
26ARAF1.41161158
27MAP3K131.38385804
28TNIK1.33114544
29CAMK11.30759592
30GRK51.28543534
31FES1.23264981
32TYRO31.21901582
33MAP3K21.17935487
34CASK1.16904831
35* PRKCG1.15630603
36SIK21.12075930
37TAOK11.10752642
38PTK2B1.09103573
39CDK181.07953810
40UHMK11.06956057
41CDK151.05436994
42CAMK2A1.01389506
43CAMK2B1.00367235
44MAPK130.99180682
45SGK2230.98399069
46SGK4940.98399069
47PRKCH0.98282994
48CDK140.95686929
49STK110.95578654
50MAP3K110.94714792
51PNCK0.94652718
52ALK0.93622785
53RAF10.93573812
54CDK11A0.93042214
55PINK10.90265010
56OXSR10.89956984
57SGK20.89469842
58SGK30.84201037
59LIMK10.81141248
60PDPK10.79105220
61RIPK10.78845328
62BMPR20.75804074
63SGK10.72042669
64CAMK40.71229030
65PAK30.71011228
66NEK10.70856639
67TESK10.69407556
68RET0.67813989
69* PDK10.67793207
70LATS20.66799354
71DYRK1A0.66131840
72SIK30.65026100
73NEK60.64046086
74MAP3K70.63179161
75LMTK20.61509765
76MAP3K10.61052776
77TNK20.57690914
78NME10.57443152
79MARK20.55534227
80PKN10.54928457
81BRSK10.53635128
82CSNK1G30.53574878
83RPS6KA30.52436070
84PHKG20.51277491
85PHKG10.51277491
86PRKG20.51085822
87FGFR20.50489219
88PRKG10.50185383
89CAMK2G0.50088445
90CSNK1A1L0.47459851
91DAPK30.47306188
92CDC42BPA0.45156009
93MAPK120.44871010
94DMPK0.44005725
95CAMK2D0.43729696
96FYN0.43698401
97MAPK100.43517584
98AKT30.42854734
99FER0.42089573
100WNK10.41670249
101PRKCZ0.40574905
102ROCK20.40214990
103CCNB10.39936120
104CSNK1E0.38513518
105MAP2K10.38506639
106PRKACA0.35943118
107PRKCE0.34495598
108CAMK1G0.33251512
109CSNK1A10.32428922
110CSNK1D0.32199775
111CSNK1G20.32108024
112WNK40.31951806
113TAOK20.31762778
114BRAF0.31351899
115ERBB20.31285046
116CSNK1G10.30375168
117PRKCB0.30293261
118PRKCA0.30215226
119MAPK80.29333745
120CAMK1D0.29130401

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.91375314
2Synaptic vesicle cycle_Homo sapiens_hsa047213.40282932
3* Long-term potentiation_Homo sapiens_hsa047203.01868338
4Olfactory transduction_Homo sapiens_hsa047402.91834812
5* Circadian entrainment_Homo sapiens_hsa047132.90685654
6* Glutamatergic synapse_Homo sapiens_hsa047242.82679810
7* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.69443050
8* GABAergic synapse_Homo sapiens_hsa047272.57465170
9* Amphetamine addiction_Homo sapiens_hsa050312.56927090
10* Morphine addiction_Homo sapiens_hsa050322.42455813
11* Salivary secretion_Homo sapiens_hsa049702.29084670
12* Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.14026732
13* Dopaminergic synapse_Homo sapiens_hsa047282.08415690
14* Insulin secretion_Homo sapiens_hsa049112.03042877
15* Gastric acid secretion_Homo sapiens_hsa049712.00585945
16* Aldosterone synthesis and secretion_Homo sapiens_hsa049251.98844991
17* Cholinergic synapse_Homo sapiens_hsa047251.89533355
18Taste transduction_Homo sapiens_hsa047421.79593994
19* Long-term depression_Homo sapiens_hsa047301.77442558
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.74772695
21* Oxytocin signaling pathway_Homo sapiens_hsa049211.71622683
22* Calcium signaling pathway_Homo sapiens_hsa040201.70712688
23Renin secretion_Homo sapiens_hsa049241.59828641
24GnRH signaling pathway_Homo sapiens_hsa049121.58162775
25Cocaine addiction_Homo sapiens_hsa050301.47545594
26* Serotonergic synapse_Homo sapiens_hsa047261.38060908
27Vitamin B6 metabolism_Homo sapiens_hsa007501.37197468
28cAMP signaling pathway_Homo sapiens_hsa040241.37137607
29Nitrogen metabolism_Homo sapiens_hsa009101.34953994
30* Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34016599
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.33702011
32Collecting duct acid secretion_Homo sapiens_hsa049661.32828969
33Type II diabetes mellitus_Homo sapiens_hsa049301.31723193
34* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28306969
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25256090
36* Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23460552
37* Gap junction_Homo sapiens_hsa045401.22704228
38Estrogen signaling pathway_Homo sapiens_hsa049151.20372263
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.17965980
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12598755
41* Glioma_Homo sapiens_hsa052141.08612476
42Oocyte meiosis_Homo sapiens_hsa041141.00675713
43Alzheimers disease_Homo sapiens_hsa050100.97834896
44Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.96523632
45* Melanogenesis_Homo sapiens_hsa049160.96397135
46* ErbB signaling pathway_Homo sapiens_hsa040120.94255823
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93178166
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.90938250
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89462232
50* Pancreatic secretion_Homo sapiens_hsa049720.89150804
51Axon guidance_Homo sapiens_hsa043600.88715181
52* Vascular smooth muscle contraction_Homo sapiens_hsa042700.88551661
53Cardiac muscle contraction_Homo sapiens_hsa042600.84791520
54Oxidative phosphorylation_Homo sapiens_hsa001900.81621457
55Vibrio cholerae infection_Homo sapiens_hsa051100.79074608
56Dorso-ventral axis formation_Homo sapiens_hsa043200.77393219
57* Thyroid hormone synthesis_Homo sapiens_hsa049180.76571902
58Dilated cardiomyopathy_Homo sapiens_hsa054140.74591712
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72388178
60Parkinsons disease_Homo sapiens_hsa050120.70591756
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70055532
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69900837
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68446694
64* MAPK signaling pathway_Homo sapiens_hsa040100.67445181
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.65921595
66* Choline metabolism in cancer_Homo sapiens_hsa052310.64510569
67Glucagon signaling pathway_Homo sapiens_hsa049220.63271108
68Inositol phosphate metabolism_Homo sapiens_hsa005620.61222105
69Bile secretion_Homo sapiens_hsa049760.58622946
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.58173088
71* VEGF signaling pathway_Homo sapiens_hsa043700.56670384
72* Rap1 signaling pathway_Homo sapiens_hsa040150.56333872
73Endocytosis_Homo sapiens_hsa041440.54515396
74* Ras signaling pathway_Homo sapiens_hsa040140.52884259
75* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51314337
76Type I diabetes mellitus_Homo sapiens_hsa049400.50097248
77Huntingtons disease_Homo sapiens_hsa050160.47484935
78Circadian rhythm_Homo sapiens_hsa047100.46890448
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46532826
80Fatty acid biosynthesis_Homo sapiens_hsa000610.45789256
81* Sphingolipid signaling pathway_Homo sapiens_hsa040710.44807351
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44314326
83Phototransduction_Homo sapiens_hsa047440.41578366
84Chemokine signaling pathway_Homo sapiens_hsa040620.40698584
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40336471
86* mTOR signaling pathway_Homo sapiens_hsa041500.39562050
87Alcoholism_Homo sapiens_hsa050340.39443628
88Arginine and proline metabolism_Homo sapiens_hsa003300.38639628
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38119026
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37830775
91Prion diseases_Homo sapiens_hsa050200.37320525
92Endometrial cancer_Homo sapiens_hsa052130.35784854
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33675007
94Ovarian steroidogenesis_Homo sapiens_hsa049130.32753992
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32596896
96Insulin signaling pathway_Homo sapiens_hsa049100.32422318
97Arginine biosynthesis_Homo sapiens_hsa002200.31508621
98Mineral absorption_Homo sapiens_hsa049780.31350991
99* Wnt signaling pathway_Homo sapiens_hsa043100.31142212
100Renal cell carcinoma_Homo sapiens_hsa052110.30654788
101* Non-small cell lung cancer_Homo sapiens_hsa052230.29578183
102* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28920065
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28822126
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28459576
105Hippo signaling pathway_Homo sapiens_hsa043900.28041426
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.27150207
107Platelet activation_Homo sapiens_hsa046110.27035730
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26401595
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.25850423
110Regulation of autophagy_Homo sapiens_hsa041400.25784328
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.25493709
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25330326
113* Tight junction_Homo sapiens_hsa045300.13348903
114Folate biosynthesis_Homo sapiens_hsa007900.11907994

Most similar genes based on co-expression Upload to Enrichr

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