PRKCH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. Mutations in this gene are associated with susceptibility to cerebral infarction. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.24856309
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.49712107
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.49712107
4regulation of gamma-delta T cell differentiation (GO:0045586)6.40418029
5negative T cell selection (GO:0043383)6.37983296
6positive thymic T cell selection (GO:0045059)6.14134524
7negative thymic T cell selection (GO:0045060)6.13465808
8regulation of gamma-delta T cell activation (GO:0046643)5.82340745
9positive T cell selection (GO:0043368)5.65240647
10thymic T cell selection (GO:0045061)5.49163100
11response to interleukin-15 (GO:0070672)5.44079222
12antigen processing and presentation of endogenous antigen (GO:0019883)5.40115174
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.32853056
14negative regulation of cell killing (GO:0031342)5.32853056
15interferon-gamma production (GO:0032609)5.25479809
16* positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.20946682
17T cell selection (GO:0045058)5.08456840
18cellular response to interleukin-15 (GO:0071350)4.81703935
19regulation of isotype switching to IgG isotypes (GO:0048302)4.80910306
20regulation of interleukin-12 biosynthetic process (GO:0045075)4.59761070
21positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.55085524
22regulation of T cell tolerance induction (GO:0002664)4.53703294
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.51117250
24T cell migration (GO:0072678)4.33067047
25T cell receptor signaling pathway (GO:0050852)4.32602728
26tolerance induction (GO:0002507)4.27759862
27leukocyte aggregation (GO:0070486)4.26467559
28regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.24910926
29positive regulation of granulocyte differentiation (GO:0030854)4.16295785
30T cell costimulation (GO:0031295)4.04810391
31regulation of regulatory T cell differentiation (GO:0045589)3.99572022
32lymphocyte costimulation (GO:0031294)3.98642738
33negative regulation of lymphocyte mediated immunity (GO:0002707)3.96647342
34positive regulation of tolerance induction (GO:0002645)3.93748689
35antigen receptor-mediated signaling pathway (GO:0050851)3.78450945
36positive regulation of isotype switching (GO:0045830)3.60818908
37antigen processing and presentation via MHC class Ib (GO:0002475)3.58945924
38JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.57898998
39negative regulation of leukocyte mediated immunity (GO:0002704)3.57812497
40activated T cell proliferation (GO:0050798)3.57407266
41regulation of T cell receptor signaling pathway (GO:0050856)3.57027431
42endothelial tube morphogenesis (GO:0061154)3.56200380
43morphogenesis of an endothelium (GO:0003159)3.56200380
44regulation of T cell mediated cytotoxicity (GO:0001914)3.55645140
45negative regulation of interleukin-12 production (GO:0032695)3.53433434
46regulation of alpha-beta T cell proliferation (GO:0046640)3.52271923
47regulation of natural killer cell mediated immunity (GO:0002715)3.51580187
48regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.51580187
49regulation of response to interferon-gamma (GO:0060330)3.50964615
50regulation of interleukin-2 biosynthetic process (GO:0045076)3.48505393
51T cell homeostasis (GO:0043029)3.47913978
52regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.46221134
53* regulation of B cell receptor signaling pathway (GO:0050855)3.44101320
54positive regulation of T cell mediated cytotoxicity (GO:0001916)3.42412132
55* regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.39962226
56positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.39900947
57positive regulation of interleukin-2 production (GO:0032743)3.38982200
58positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.37832461
59positive regulation of natural killer cell mediated immunity (GO:0002717)3.37832461
60regulation of tolerance induction (GO:0002643)3.36882019
61positive regulation of humoral immune response (GO:0002922)3.34450871
62positive regulation of immunoglobulin mediated immune response (GO:0002891)3.33810512
63positive regulation of B cell mediated immunity (GO:0002714)3.33810512
64mast cell activation (GO:0045576)3.32728075
65regulation of type I interferon-mediated signaling pathway (GO:0060338)3.29716929
66leukocyte cell-cell adhesion (GO:0007159)3.28229666
67negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.23590038
68positive regulation of alpha-beta T cell proliferation (GO:0046641)3.23193006
69Peyers patch development (GO:0048541)3.21161672
70mucosal-associated lymphoid tissue development (GO:0048537)3.21161672
71negative regulation of T cell mediated immunity (GO:0002710)3.20368191
72response to type I interferon (GO:0034340)3.20239848
73negative regulation of erythrocyte differentiation (GO:0045647)3.18596198
74T cell differentiation (GO:0030217)3.18105430
75regulation of isotype switching (GO:0045191)3.16197031
76positive regulation of B cell differentiation (GO:0045579)3.15081911
77type I interferon signaling pathway (GO:0060337)3.13453544
78cellular response to type I interferon (GO:0071357)3.13453544
79myeloid dendritic cell activation (GO:0001773)3.10746798
80tyrosine phosphorylation of STAT protein (GO:0007260)3.09945845
81regulation of alpha-beta T cell activation (GO:0046634)3.09521945
82alpha-beta T cell activation (GO:0046631)3.07274857
83negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.07103068
84modulation by symbiont of host defense response (GO:0052031)3.07089800
85modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.07089800
86modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.07089800
87positive regulation by organism of defense response of other organism involved in symbiotic interact3.07089800
88modulation by symbiont of host immune response (GO:0052553)3.07089800
89positive regulation by symbiont of host defense response (GO:0052509)3.07089800
90NIK/NF-kappaB signaling (GO:0038061)3.05485253
91detection of other organism (GO:0098543)3.05223740
92regulation of leukocyte mediated cytotoxicity (GO:0001910)3.04406903
93regulation of immunoglobulin mediated immune response (GO:0002889)3.04253183
94lymphocyte homeostasis (GO:0002260)3.03129557
95regulation of B cell differentiation (GO:0045577)3.02909789
96negative regulation of T-helper cell differentiation (GO:0045623)3.02717309
97negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.02717309
98positive regulation of DNA recombination (GO:0045911)3.02317340
99natural killer cell activation (GO:0030101)3.00560653
100detection of bacterium (GO:0016045)3.00224264
101regulation of B cell mediated immunity (GO:0002712)2.98867695
102CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.95288606
103T-helper cell differentiation (GO:0042093)2.95288606
104B cell receptor signaling pathway (GO:0050853)2.95243516
105alpha-beta T cell differentiation (GO:0046632)2.94130171
106regulation of granulocyte differentiation (GO:0030852)2.93447774
107lymphocyte migration (GO:0072676)2.93341571
108positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.92936294
109T cell activation (GO:0042110)2.92801389
110negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.92353051
111Arp2/3 complex-mediated actin nucleation (GO:0034314)2.91309821
112positive regulation of alpha-beta T cell activation (GO:0046635)2.90379521
113angiogenesis involved in wound healing (GO:0060055)2.90209235
114myeloid dendritic cell differentiation (GO:0043011)2.89292722
115regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.89073343
116interferon-gamma-mediated signaling pathway (GO:0060333)2.88307906
117natural killer cell differentiation (GO:0001779)2.87925852
118regulation of interleukin-2 production (GO:0032663)2.86491331
119negative regulation of adaptive immune response (GO:0002820)2.85872592
120T cell proliferation (GO:0042098)2.85805886
121cellular extravasation (GO:0045123)2.85283638
122regulation of cell killing (GO:0031341)2.84380379
123negative regulation of innate immune response (GO:0045824)2.83143189
124macrophage activation involved in immune response (GO:0002281)2.82329639
125positive regulation of lamellipodium assembly (GO:0010592)2.81685088
126lymph node development (GO:0048535)2.81235806
127neutrophil activation involved in immune response (GO:0002283)2.81177156
128immune response-activating cell surface receptor signaling pathway (GO:0002429)2.75642790
129leukocyte tethering or rolling (GO:0050901)2.75518595
130regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.74652636
131hepatocyte apoptotic process (GO:0097284)2.72671524
132positive regulation of cell killing (GO:0031343)2.70713343

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.89805207
2* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.64982689
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.90366790
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.70697629
5MYC_22102868_ChIP-Seq_BL_Human3.50890016
6* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.48009156
7* RUNX_20019798_ChIP-Seq_JUKART_Human3.31400412
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.23228076
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.21484658
10* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.16450719
11E2F7_22180533_ChIP-Seq_HELA_Human3.14444924
12EGR1_19374776_ChIP-ChIP_THP-1_Human3.12491886
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.12033940
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.11691444
15STAT4_19710469_ChIP-ChIP_TH1__Mouse3.04389779
16* MYB_26560356_Chip-Seq_TH2_Human2.99400187
17MAF_26560356_Chip-Seq_TH1_Human2.88026120
18SCL_19346495_ChIP-Seq_HPC-7_Human2.61816730
19MYB_26560356_Chip-Seq_TH1_Human2.55064674
20UTX_26944678_Chip-Seq_JUKART_Human2.52961533
21VDR_21846776_ChIP-Seq_THP-1_Human2.39111587
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.35612421
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.28546806
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.28366378
25* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.27193046
26* TCF7_22412390_ChIP-Seq_EML_Mouse2.26783896
27* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.26199530
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20217337
29NOTCH1_21737748_ChIP-Seq_TLL_Human2.13082268
30IRF8_27001747_Chip-Seq_BMDM_Mouse2.04080280
31KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.03233347
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.96821464
33* RUNX1_22412390_ChIP-Seq_EML_Mouse1.92488405
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.90807844
35MAF_26560356_Chip-Seq_TH2_Human1.87094948
36KDM2B_26808549_Chip-Seq_DND41_Human1.85897748
37GATA3_27048872_Chip-Seq_THYMUS_Human1.85644910
38SPI1_23547873_ChIP-Seq_NB4_Human1.82923125
39* VDR_24763502_ChIP-Seq_THP-1_Human1.81699630
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.80998672
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.78107872
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.77450869
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.75293430
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.70337594
45* SPI1_23127762_ChIP-Seq_K562_Human1.66513042
46* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.63944513
47TP63_17297297_ChIP-ChIP_HaCaT_Human1.54462978
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47915762
49* VDR_24787735_ChIP-Seq_THP-1_Human1.47731035
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40144466
51NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.39998512
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38979796
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34998303
54KDM2B_26808549_Chip-Seq_JURKAT_Human1.31849746
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.30887052
56TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30607149
57RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.28000581
58* PU_27001747_Chip-Seq_BMDM_Mouse1.27792255
59GATA2_21666600_ChIP-Seq_HMVEC_Human1.26582040
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26428628
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.21680905
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16676204
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16509132
64* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16424173
65FOXM1_23109430_ChIP-Seq_U2OS_Human1.15605427
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12535178
67EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07361970
68SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07165996
69GATA3_26560356_Chip-Seq_TH2_Human1.06406432
70* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06080522
71VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03177613
72CIITA_25753668_ChIP-Seq_RAJI_Human1.03043639
73CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01286771
74GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00588648
75ELF1_17652178_ChIP-ChIP_JURKAT_Human1.00156409
76* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00002008
77GATA1_22025678_ChIP-Seq_K562_Human0.99557233
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97521651
79GATA1_19941827_ChIP-Seq_MEL_Mouse0.96233667
80* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95929935
81NCOR1_26117541_ChIP-Seq_K562_Human0.95893560
82GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94820225
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94611862
84CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93879368
85GATA1_19941826_ChIP-Seq_K562_Human0.93391362
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.91916722
87NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90590397
88LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90456441
89CLOCK_20551151_ChIP-Seq_293T_Human0.88604944
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88226917
91CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88163721
92FOXO3_23340844_ChIP-Seq_DLD1_Human0.86581717
93SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.86443646
94HIF1A_21447827_ChIP-Seq_MCF-7_Human0.84974653
95CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.84219772
96SMRT_27268052_Chip-Seq_Bcells_Human0.83942639
97* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.83531639
98THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.81678751
99RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81387230
100ERG_20887958_ChIP-Seq_HPC-7_Mouse0.81002524
101Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80488246
102PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79862803
103GATA2_19941826_ChIP-Seq_K562_Human0.79660692
104GATA3_26560356_Chip-Seq_TH1_Human0.79261702
105CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78336221
106LXR_22292898_ChIP-Seq_THP-1_Human0.78087604
107TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.77101190
108PU.1_20513432_ChIP-Seq_Bcells_Mouse0.75703286
109FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.75264791
110FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.72562817
111GATA1_19941827_ChIP-Seq_MEL86_Mouse0.71716195
112SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.71508478
113GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70945351
114E2F4_17652178_ChIP-ChIP_JURKAT_Human0.70244588
115TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.69559093
116RACK7_27058665_Chip-Seq_MCF-7_Human0.69257928
117KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.69002981
118PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.68403117

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.37471528
2MP0005671_abnormal_response_to3.58898244
3MP0001835_abnormal_antigen_presentation3.14851779
4MP0000685_abnormal_immune_system3.13097731
5MP0003300_gastrointestinal_ulcer3.08517448
6MP0003724_increased_susceptibility_to2.97474432
7MP0002166_altered_tumor_susceptibility2.94426039
8MP0001800_abnormal_humoral_immune2.79898014
9MP0002396_abnormal_hematopoietic_system2.57418359
10MP0001873_stomach_inflammation2.50995381
11MP0005000_abnormal_immune_tolerance2.50567563
12MP0003436_decreased_susceptibility_to2.48573924
13MP0009785_altered_susceptibility_to2.48097201
14MP0001790_abnormal_immune_system2.47131728
15MP0005387_immune_system_phenotype2.47131728
16MP0002420_abnormal_adaptive_immunity2.46323328
17MP0002723_abnormal_immune_serum2.45908494
18MP0002398_abnormal_bone_marrow2.44484566
19MP0001819_abnormal_immune_cell2.43422619
20MP0002452_abnormal_antigen_presenting2.36635896
21MP0003303_peritoneal_inflammation2.32728649
22MP0002006_tumorigenesis2.32608581
23MP0005025_abnormal_response_to2.28493528
24MP0002405_respiratory_system_inflammati2.26639112
25MP0009333_abnormal_splenocyte_physiolog2.25290015
26MP0004947_skin_inflammation2.24259640
27MP0000703_abnormal_thymus_morphology2.21114741
28MP0010155_abnormal_intestine_physiology2.14439244
29MP0000716_abnormal_immune_system2.09914770
30MP0000465_gastrointestinal_hemorrhage2.04198228
31MP0002722_abnormal_immune_system2.02236207
32MP0004808_abnormal_hematopoietic_stem2.00825338
33MP0006082_CNS_inflammation1.98598322
34MP0004510_myositis1.98347279
35MP0000689_abnormal_spleen_morphology1.97312038
36MP0003866_abnormal_defecation1.95498483
37MP0010368_abnormal_lymphatic_system1.88756395
38MP0005464_abnormal_platelet_physiology1.85966109
39MP0002419_abnormal_innate_immunity1.82068537
40MP0002429_abnormal_blood_cell1.76457056
41MP0002148_abnormal_hypersensitivity_rea1.75000121
42MP0009278_abnormal_bone_marrow1.68922335
43MP0001853_heart_inflammation1.67928480
44MP0001851_eye_inflammation1.65080299
45MP0001879_abnormal_lymphatic_vessel1.64610901
46MP0002933_joint_inflammation1.63540277
47MP0001545_abnormal_hematopoietic_system1.56326617
48MP0005397_hematopoietic_system_phenotyp1.56326617
49MP0001845_abnormal_inflammatory_respons1.55343466
50MP0003448_altered_tumor_morphology1.36931528
51MP0006054_spinal_hemorrhage1.35151953
52MP0005167_abnormal_blood-brain_barrier1.28586470
53MP0001533_abnormal_skeleton_physiology1.28436152
54MP0010234_abnormal_vibrissa_follicle1.25431495
55MP0000858_altered_metastatic_potential1.22121888
56MP0010352_gastrointestinal_tract_polyps1.21421280
57MP0003828_pulmonary_edema1.18547132
58MP0000490_abnormal_crypts_of1.17705152
59MP0005451_abnormal_body_composition1.16023508
60MP0004381_abnormal_hair_follicle1.14584400
61MP0005310_abnormal_salivary_gland1.10428976
62MP0002138_abnormal_hepatobiliary_system1.05934012
63MP0008469_abnormal_protein_level1.04507617
64MP0002998_abnormal_bone_remodeling1.02756820
65MP0002277_abnormal_respiratory_mucosa1.00592438
66MP0008260_abnormal_autophagy1.00304312
67MP0004883_abnormal_blood_vessel0.97941075
68MP0008961_abnormal_basal_metabolism0.97170600
69MP0003566_abnormal_cell_adhesion0.96699517
70* MP0002019_abnormal_tumor_incidence0.87630713
71MP0000343_altered_response_to0.86848477
72MP0000249_abnormal_blood_vessel0.85030983
73MP0003172_abnormal_lysosome_physiology0.84776105
74MP0002009_preneoplasia0.83809781
75MP0004130_abnormal_muscle_cell0.83465274
76MP0003191_abnormal_cellular_cholesterol0.82516907
77MP0003183_abnormal_peptide_metabolism0.81152257
78MP0003453_abnormal_keratinocyte_physiol0.80434632
79MP0008057_abnormal_DNA_replication0.79318184
80MP0005076_abnormal_cell_differentiation0.79048762
81MP0008004_abnormal_stomach_pH0.72583628
82MP0005075_abnormal_melanosome_morpholog0.72533820
83MP0000569_abnormal_digit_pigmentation0.70367326
84MP0003091_abnormal_cell_migration0.70190326
85MP0003045_fibrosis0.69727697
86MP0002693_abnormal_pancreas_physiology0.69046332
87MP0009763_increased_sensitivity_to0.68457077
88MP0005164_abnormal_response_to0.68444584
89* MP0001216_abnormal_epidermal_layer0.66438547
90MP0002132_abnormal_respiratory_system0.65737789
91MP0003279_aneurysm0.65456765
92MP0002332_abnormal_exercise_endurance0.65275561
93MP0003690_abnormal_glial_cell0.65034755
94MP0009764_decreased_sensitivity_to0.64844271
95* MP0005023_abnormal_wound_healing0.62866037
96MP0000015_abnormal_ear_pigmentation0.62606912
97MP0005174_abnormal_tail_pigmentation0.62475656
98MP0003943_abnormal_hepatobiliary_system0.62423407
99MP0003795_abnormal_bone_structure0.58432027
100MP0000477_abnormal_intestine_morphology0.57036955
101MP0005166_decreased_susceptibility_to0.56944529
102* MP0001191_abnormal_skin_condition0.56838559
103MP0001663_abnormal_digestive_system0.56451926
104MP0010307_abnormal_tumor_latency0.55964725
105MP0000383_abnormal_hair_follicle0.53875149
106MP0000767_abnormal_smooth_muscle0.52637632
107MP0004185_abnormal_adipocyte_glucose0.52462096
108MP0009931_abnormal_skin_appearance0.52451584
109MP0001243_abnormal_dermal_layer0.52341884
110MP0002796_impaired_skin_barrier0.52143681
111MP0000609_abnormal_liver_physiology0.51915933
112MP0005390_skeleton_phenotype0.51357093
113MP0002086_abnormal_extraembryonic_tissu0.50712352
114MP0002128_abnormal_blood_circulation0.50516182
115MP0009115_abnormal_fat_cell0.50471770
116MP0009765_abnormal_xenobiotic_induced0.50425471
117MP0004484_altered_response_of0.49707510
118MP0001765_abnormal_ion_homeostasis0.49116855
119MP0001348_abnormal_lacrimal_gland0.47511770
120MP0000604_amyloidosis0.47306109
121MP0002136_abnormal_kidney_physiology0.45631100
122MP0003075_altered_response_to0.43580495
123MP0003656_abnormal_erythrocyte_physiolo0.42683112
124MP0002168_other_aberrant_phenotype0.41780320

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.76637360
2Abnormality of T cell number (HP:0011839)5.55394483
3Elevated erythrocyte sedimentation rate (HP:0003565)5.45157309
4Abnormality of the nasal mucosa (HP:0000433)4.48433849
5Abnormality of T cells (HP:0002843)4.42186662
6Myositis (HP:0100614)4.39259449
7Recurrent fungal infections (HP:0002841)4.36107367
8Recurrent bronchitis (HP:0002837)4.20936140
9Spontaneous hematomas (HP:0007420)4.18803319
10Recurrent viral infections (HP:0004429)4.14749575
11IgM deficiency (HP:0002850)4.09096725
12Stomatitis (HP:0010280)4.08866701
13Chronic otitis media (HP:0000389)4.07291077
14Severe combined immunodeficiency (HP:0004430)4.03323590
15Eczematoid dermatitis (HP:0000976)4.02868939
16Nasal polyposis (HP:0100582)4.01999281
17Panhypogammaglobulinemia (HP:0003139)3.89985057
18Recurrent cutaneous fungal infections (HP:0011370)3.72738803
19Chronic mucocutaneous candidiasis (HP:0002728)3.72738803
20Combined immunodeficiency (HP:0005387)3.68958296
21Autoimmune hemolytic anemia (HP:0001890)3.56883954
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.54730422
23Abnormality of macrophages (HP:0004311)3.46580465
24Abnormality of the fingertips (HP:0001211)3.34614050
25Increased IgE level (HP:0003212)3.33069631
26Orchitis (HP:0100796)3.32420283
27IgG deficiency (HP:0004315)3.24965057
28Inflammation of the large intestine (HP:0002037)3.24450822
29Gastrointestinal inflammation (HP:0004386)3.21404869
30Retrobulbar optic neuritis (HP:0100654)3.21349450
31Optic neuritis (HP:0100653)3.21349450
32Abnormality of T cell physiology (HP:0011840)3.18615485
33Thyroiditis (HP:0100646)3.15135834
34B lymphocytopenia (HP:0010976)3.13971938
35Abnormality of B cell number (HP:0010975)3.13971938
36Pustule (HP:0200039)3.12177071
37Hemoptysis (HP:0002105)3.10995415
38Chronic diarrhea (HP:0002028)3.09538787
39Autoimmune thrombocytopenia (HP:0001973)3.06128173
40Hematochezia (HP:0002573)3.05285066
41Thrombocytosis (HP:0001894)2.93725710
42Eosinophilia (HP:0001880)2.88730021
43Abnormality of eosinophils (HP:0001879)2.87578410
44Arterial thrombosis (HP:0004420)2.87099023
45Leukocytosis (HP:0001974)2.86900262
46Prolonged bleeding time (HP:0003010)2.83573907
47Meningitis (HP:0001287)2.82634856
48Lymphopenia (HP:0001888)2.82337879
49Abnormality of cells of the lymphoid lineage (HP:0012140)2.74056491
50Recurrent abscess formation (HP:0002722)2.72336442
51Vasculitis (HP:0002633)2.71756494
52Colitis (HP:0002583)2.70949466
53Increased density of long bones (HP:0006392)2.65722553
54IgA deficiency (HP:0002720)2.65660824
55Papilloma (HP:0012740)2.59087180
56Verrucae (HP:0200043)2.59087180
57Epistaxis (HP:0000421)2.54599785
58Granulocytopenia (HP:0001913)2.53926536
59Pulmonary embolism (HP:0002204)2.51911720
60Agammaglobulinemia (HP:0004432)2.49061393
61Joint swelling (HP:0001386)2.47513889
62Keratoconjunctivitis sicca (HP:0001097)2.45636759
63Recurrent skin infections (HP:0001581)2.44399122
64Chest pain (HP:0100749)2.43741488
65Recurrent gram-negative bacterial infections (HP:0005420)2.42823652
66Cellulitis (HP:0100658)2.40645765
67Acute hepatic failure (HP:0006554)2.39298010
68Anorexia (HP:0002039)2.39160265
69Pulmonary infiltrates (HP:0002113)2.37495844
70Gingivitis (HP:0000230)2.35862949
71Mediastinal lymphadenopathy (HP:0100721)2.35229927
72Papilledema (HP:0001085)2.31414982
73Bronchitis (HP:0012387)2.29890638
74Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.29869460
75Polycythemia (HP:0001901)2.28529868
76Interstitial pulmonary disease (HP:0006530)2.26738713
77Hypergammaglobulinemia (HP:0010702)2.24244082
78Persistence of primary teeth (HP:0006335)2.23582764
79Slow saccadic eye movements (HP:0000514)2.22655657
80Encephalitis (HP:0002383)2.21491419
81Lymphoma (HP:0002665)2.18914399
82Keratoconjunctivitis (HP:0001096)2.17555702
83Chronic sinusitis (HP:0011109)2.16191056
84Abnormal platelet function (HP:0011869)2.16131999
85Impaired platelet aggregation (HP:0003540)2.16131999
86Recurrent bacterial skin infections (HP:0005406)2.12964707
87Abnormality of the pleura (HP:0002103)2.12491940
88Urticaria (HP:0001025)2.11451235
89Stomach cancer (HP:0012126)2.10504607
90Abnormal platelet volume (HP:0011876)2.09273941
91Keratitis (HP:0000491)2.08863588
92Hypoproteinemia (HP:0003075)2.08612722
93Gastrointestinal infarctions (HP:0005244)2.07839957
94Chronic obstructive pulmonary disease (HP:0006510)2.06157619
95Obstructive lung disease (HP:0006536)2.06157619
96Basal cell carcinoma (HP:0002671)2.05779890
97Bicuspid aortic valve (HP:0001647)2.05334437
98Fatigue (HP:0012378)2.00809599
99Hypoplasia of the thymus (HP:0000778)1.99573543
100Hypochromic anemia (HP:0001931)1.97939844
101Reduced subcutaneous adipose tissue (HP:0003758)1.97721964
102Increased IgM level (HP:0003496)1.96196394
103Skin ulcer (HP:0200042)1.95002697
104Gangrene (HP:0100758)1.94370411
105Esophageal varix (HP:0002040)1.92555137
106Cheilitis (HP:0100825)1.92286396
107Neoplasm of the tracheobronchial system (HP:0100552)1.91865521
108Polyneuropathy (HP:0001271)1.90980516
109Glomerulopathy (HP:0100820)1.90456604
110Gingival bleeding (HP:0000225)1.90248199
111Alveolar cell carcinoma (HP:0006519)1.88505022
112Vertigo (HP:0002321)1.87907041
113Aortic aneurysm (HP:0004942)1.87754228
114Microcytic anemia (HP:0001935)1.87416585
115Abnormality of the prostate (HP:0008775)1.86729580
116Viral hepatitis (HP:0006562)1.86413046
117Periodontitis (HP:0000704)1.85744761
118Hemiplegia (HP:0002301)1.85049144
119Cutis marmorata (HP:0000965)1.84335810
120Abnormality of the endocardium (HP:0004306)1.84157735
121Sepsis (HP:0100806)1.82820472
122Petechiae (HP:0000967)1.81478826
123Aplasia/Hypoplasia of the thymus (HP:0010515)1.81418317
124Increased CSF protein (HP:0002922)1.80706685
125Osteomyelitis (HP:0002754)1.79882759

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.97170249
2TXK4.69049611
3JAK33.43664847
4FGFR43.09713378
5KDR3.04176110
6ZAP702.73116404
7ITK2.64266211
8IKBKE2.58520448
9RIPK42.58322801
10TYK22.57029995
11STK102.56677367
12TGFBR22.41496151
13TIE12.39106184
14EEF2K2.36096752
15PRPF4B2.32278305
16FGFR32.32097831
17MAP3K101.91000127
18TBK11.89598482
19MAP3K141.87588885
20JAK11.85472210
21PKN21.85281872
22TGFBR11.75271210
23TEC1.73226593
24KIT1.70921498
25CAMKK21.69492283
26NLK1.69224370
27LCK1.65121036
28GRK61.53200677
29CSK1.49672745
30HCK1.44430278
31TRIB31.38177816
32LRRK21.37487889
33BTK1.34378918
34FES1.28957090
35MAP2K31.23877967
36SYK1.22594945
37MAP3K131.15352194
38IKBKB1.14264928
39PIK3CG1.13616607
40EPHB11.09197202
41CAMKK11.08501636
42SIK31.08285249
43BLK1.07925969
44JAK21.06567948
45MARK31.04171390
46RPS6KA41.01569178
47PTK61.01228048
48MST40.96296403
49RIPK10.95555727
50BMPR20.95194276
51NME20.92754884
52PIM10.91381470
53MAP3K70.89041535
54IRAK10.88411228
55FRK0.88193296
56TTN0.87899303
57CHUK0.86776517
58FGR0.84081055
59ERN10.82654636
60CLK10.81433477
61PRKCQ0.80552449
62CSF1R0.78069546
63SIK20.76228163
64CDK120.74527479
65MAP3K30.73075910
66EPHA30.72331934
67IRAK40.70494507
68TAOK10.65708291
69TESK20.64998441
70MAP2K60.64349721
71LYN0.63983637
72CDK40.63582225
73CDK60.63385514
74DMPK0.62838138
75PDGFRB0.61960135
76SGK20.60255613
77FLT30.59393409
78SGK30.55212318
79PTK2B0.54035380
80MAPK120.53758426
81STK380.52368018
82YES10.49962880
83HIPK20.49786825
84CDK90.49602841
85ALK0.49441689
86TNK20.48871236
87RPS6KB20.48498633
88GRK70.48447638
89TYRO30.48124300
90FGFR20.47552872
91* PDK10.47275685
92MAP3K110.47216310
93MAPK110.46113108
94EGFR0.43424550
95STK40.43101587
96NEK60.42522903
97MARK20.40836951
98SMG10.39755088
99MAPK70.39587966
100MAP3K80.39322045
101IGF1R0.37709885
102TSSK60.37395681
103STK110.36091598
104WNK10.35894178
105MAPK40.35386046
106CDC42BPA0.34752383
107MAP3K20.33794723
108NEK20.33043699
109TAOK20.32191957
110FGFR10.32054195
111CAMK40.31872116
112RPS6KC10.28242926
113FYN0.28223365
114TRPM70.28188056
115RET0.27930509
116RPS6KA50.27838319
117MAPKAPK20.27164267
118INSR0.27131002
119MAP3K10.27107472
120BRD40.26976690
121TAOK30.25509052
122RPS6KA60.25337786
123PRKD20.24718603
124PASK0.23923470
125MAPK30.22223035
126MELK0.21904357
127PRKD10.21793486
128MAPKAPK30.21767328

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.43393220
2T cell receptor signaling pathway_Homo sapiens_hsa046603.19816779
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.01687609
4Measles_Homo sapiens_hsa051622.65303311
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.61304224
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.50335685
7Osteoclast differentiation_Homo sapiens_hsa043802.25061684
8Antigen processing and presentation_Homo sapiens_hsa046122.19839053
9Leishmaniasis_Homo sapiens_hsa051402.18471034
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.12078319
11B cell receptor signaling pathway_Homo sapiens_hsa046622.01983824
12Graft-versus-host disease_Homo sapiens_hsa053322.00876099
13Allograft rejection_Homo sapiens_hsa053301.99628708
14Jak-STAT signaling pathway_Homo sapiens_hsa046301.90966749
15Hematopoietic cell lineage_Homo sapiens_hsa046401.88920344
16Leukocyte transendothelial migration_Homo sapiens_hsa046701.71667276
17Viral myocarditis_Homo sapiens_hsa054161.71048694
18Toxoplasmosis_Homo sapiens_hsa051451.68536146
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.64797806
20Acute myeloid leukemia_Homo sapiens_hsa052211.58055547
21Herpes simplex infection_Homo sapiens_hsa051681.52182759
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.40987567
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.40091414
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39380711
25Hepatitis B_Homo sapiens_hsa051611.39265061
26TNF signaling pathway_Homo sapiens_hsa046681.39007572
27Chronic myeloid leukemia_Homo sapiens_hsa052201.37548705
28Autoimmune thyroid disease_Homo sapiens_hsa053201.36266726
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.36131611
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.34710648
31Chemokine signaling pathway_Homo sapiens_hsa040621.32225756
32Malaria_Homo sapiens_hsa051441.30534284
33Shigellosis_Homo sapiens_hsa051311.29951301
34Platelet activation_Homo sapiens_hsa046111.26308361
35Influenza A_Homo sapiens_hsa051641.25451070
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.24478452
37Pancreatic cancer_Homo sapiens_hsa052121.23749341
38HTLV-I infection_Homo sapiens_hsa051661.21931797
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17733242
40Apoptosis_Homo sapiens_hsa042101.15474934
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.15177093
42Staphylococcus aureus infection_Homo sapiens_hsa051501.13749215
43Prolactin signaling pathway_Homo sapiens_hsa049171.05355521
44Legionellosis_Homo sapiens_hsa051341.05128860
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04689880
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04104837
47VEGF signaling pathway_Homo sapiens_hsa043700.99348401
48Hepatitis C_Homo sapiens_hsa051600.98845162
49Small cell lung cancer_Homo sapiens_hsa052220.97469918
50Viral carcinogenesis_Homo sapiens_hsa052030.95138788
51Colorectal cancer_Homo sapiens_hsa052100.93974666
52Pertussis_Homo sapiens_hsa051330.93922613
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92381531
54Tuberculosis_Homo sapiens_hsa051520.92362750
55Notch signaling pathway_Homo sapiens_hsa043300.87380231
56Asthma_Homo sapiens_hsa053100.85180116
57Epstein-Barr virus infection_Homo sapiens_hsa051690.85169489
58Salmonella infection_Homo sapiens_hsa051320.83148536
59Ribosome_Homo sapiens_hsa030100.82794011
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.80371351
61Non-small cell lung cancer_Homo sapiens_hsa052230.79908015
62Type I diabetes mellitus_Homo sapiens_hsa049400.79559413
63Caffeine metabolism_Homo sapiens_hsa002320.77995459
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77324883
65Thyroid cancer_Homo sapiens_hsa052160.67822337
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65107030
67HIF-1 signaling pathway_Homo sapiens_hsa040660.64944095
68Rap1 signaling pathway_Homo sapiens_hsa040150.62072643
69Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62071169
70Insulin resistance_Homo sapiens_hsa049310.60992622
71Adherens junction_Homo sapiens_hsa045200.60784812
72Choline metabolism in cancer_Homo sapiens_hsa052310.60504639
73Endocytosis_Homo sapiens_hsa041440.59699772
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59134850
75* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57533424
76Focal adhesion_Homo sapiens_hsa045100.57061503
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56205241
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.54795237
79Renal cell carcinoma_Homo sapiens_hsa052110.54589099
80Rheumatoid arthritis_Homo sapiens_hsa053230.52768025
81Other glycan degradation_Homo sapiens_hsa005110.52262998
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51400298
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.51170185
84MicroRNAs in cancer_Homo sapiens_hsa052060.51025652
85FoxO signaling pathway_Homo sapiens_hsa040680.50784678
86Proteoglycans in cancer_Homo sapiens_hsa052050.49606111
87African trypanosomiasis_Homo sapiens_hsa051430.49278447
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48656159
89Endometrial cancer_Homo sapiens_hsa052130.48185506
90Pathways in cancer_Homo sapiens_hsa052000.48044460
91mTOR signaling pathway_Homo sapiens_hsa041500.47784514
92Regulation of autophagy_Homo sapiens_hsa041400.47552531
93MAPK signaling pathway_Homo sapiens_hsa040100.45899643
94Prostate cancer_Homo sapiens_hsa052150.45625553
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45331572
96Dorso-ventral axis formation_Homo sapiens_hsa043200.43701662
97p53 signaling pathway_Homo sapiens_hsa041150.43125061
98Inositol phosphate metabolism_Homo sapiens_hsa005620.39747750
99Non-homologous end-joining_Homo sapiens_hsa034500.39299549
100ErbB signaling pathway_Homo sapiens_hsa040120.39250704
101Type II diabetes mellitus_Homo sapiens_hsa049300.39117391
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38592279
103Phagosome_Homo sapiens_hsa041450.34936025
104Amoebiasis_Homo sapiens_hsa051460.34647996
105GnRH signaling pathway_Homo sapiens_hsa049120.34291581
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33183937
107Glioma_Homo sapiens_hsa052140.33103542
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.32946980
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31135117
110Spliceosome_Homo sapiens_hsa030400.29839014
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29548771
112ABC transporters_Homo sapiens_hsa020100.29525831
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.29228452
114Ras signaling pathway_Homo sapiens_hsa040140.28527789
115Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26985861
116Circadian rhythm_Homo sapiens_hsa047100.26652564
117DNA replication_Homo sapiens_hsa030300.24763199

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