PRKCI

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.85138217
2nuclear pore organization (GO:0006999)4.74468244
3regulation of gene silencing by RNA (GO:0060966)4.62809423
4regulation of posttranscriptional gene silencing (GO:0060147)4.62809423
5regulation of gene silencing by miRNA (GO:0060964)4.62809423
6paraxial mesoderm development (GO:0048339)4.61774432
7regulation of hippo signaling (GO:0035330)4.19712045
8hippo signaling (GO:0035329)4.11644615
9polarized epithelial cell differentiation (GO:0030859)4.03289318
10establishment of integrated proviral latency (GO:0075713)4.02866504
11hemidesmosome assembly (GO:0031581)4.01652232
12positive regulation of SMAD protein import into nucleus (GO:0060391)3.92928302
13pre-miRNA processing (GO:0031054)3.92386708
14heterochromatin organization (GO:0070828)3.78998004
15anterior/posterior axis specification, embryo (GO:0008595)3.76456802
16protein complex localization (GO:0031503)3.73316379
17regulation of SMAD protein import into nucleus (GO:0060390)3.56072755
18cellular protein complex localization (GO:0034629)3.48126417
19protein localization to chromosome, centromeric region (GO:0071459)3.44675961
20pore complex assembly (GO:0046931)3.41727279
21regulation of translational fidelity (GO:0006450)3.38038311
22histone H2A monoubiquitination (GO:0035518)3.28998875
23lung-associated mesenchyme development (GO:0060484)3.24853952
24notochord development (GO:0030903)3.19342549
25ribosome assembly (GO:0042255)3.16643143
26bundle of His cell to Purkinje myocyte communication (GO:0086069)3.15111530
27spindle assembly involved in mitosis (GO:0090307)3.14725861
28mitotic sister chromatid cohesion (GO:0007064)3.14482475
29regulation of translational termination (GO:0006449)3.10261677
30desmosome organization (GO:0002934)3.08364292
31epithelial cell-cell adhesion (GO:0090136)3.08164220
32intestinal epithelial cell development (GO:0060576)3.07981186
33DNA unwinding involved in DNA replication (GO:0006268)3.07768400
34protein localization to kinetochore (GO:0034501)3.07440584
35negative regulation of DNA repair (GO:0045738)3.05117504
36regulation of sister chromatid cohesion (GO:0007063)3.03537102
37* establishment of apical/basal cell polarity (GO:0035089)3.00401440
38planar cell polarity pathway involved in neural tube closure (GO:0090179)2.97087947
39mitotic nuclear envelope disassembly (GO:0007077)2.96277773
40sister chromatid segregation (GO:0000819)2.94318525
41metaphase plate congression (GO:0051310)2.94253154
42DNA replication-dependent nucleosome organization (GO:0034723)2.93763461
43DNA replication-dependent nucleosome assembly (GO:0006335)2.93763461
44glucocorticoid receptor signaling pathway (GO:0042921)2.92510901
45membrane disassembly (GO:0030397)2.91555620
46nuclear envelope disassembly (GO:0051081)2.91555620
47NLS-bearing protein import into nucleus (GO:0006607)2.87145956
48cytoskeletal anchoring at plasma membrane (GO:0007016)2.86089810
49trophectodermal cell differentiation (GO:0001829)2.85204200
50CENP-A containing nucleosome assembly (GO:0034080)2.84102576
51chromatin remodeling at centromere (GO:0031055)2.83799994
52regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.82822796
53embryonic foregut morphogenesis (GO:0048617)2.80879003
54regulation of RNA export from nucleus (GO:0046831)2.77999479
55microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.77980412
56cell-substrate junction assembly (GO:0007044)2.77497982
57regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.76380808
58negative regulation of histone methylation (GO:0031061)2.75304637
59adherens junction assembly (GO:0034333)2.74238033
60chromatin assembly (GO:0031497)2.72890083
61regulation of mitotic spindle organization (GO:0060236)2.72820328
62dorsal/ventral axis specification (GO:0009950)2.71913481
63DNA replication checkpoint (GO:0000076)2.71268442
64gap junction assembly (GO:0016264)2.70598149
65double-strand break repair via nonhomologous end joining (GO:0006303)2.70156606
66non-recombinational repair (GO:0000726)2.70156606
67ectodermal placode formation (GO:0060788)2.69775460
68formation of translation preinitiation complex (GO:0001731)2.69014650
69regulation of centriole replication (GO:0046599)2.68823469
70negative regulation of keratinocyte proliferation (GO:0010839)2.68048390
71mesodermal cell differentiation (GO:0048333)2.66177123
72regulation of transforming growth factor beta2 production (GO:0032909)2.64568686
73establishment of viral latency (GO:0019043)2.64489817
74regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.63615361
75regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.63158610
76interferon-gamma secretion (GO:0072643)2.62256255
77regulation of centrosome duplication (GO:0010824)2.59986655
78positive regulation of catenin import into nucleus (GO:0035413)2.59979410
79ATP-dependent chromatin remodeling (GO:0043044)2.59892281
80regulation of cell fate specification (GO:0042659)2.59402927
81regulation of spindle organization (GO:0090224)2.59026156
82regulation of chromosome segregation (GO:0051983)2.58865296
83mitotic sister chromatid segregation (GO:0000070)2.57531836
84peptidyl-lysine dimethylation (GO:0018027)2.57352648
85negative regulation of chondrocyte differentiation (GO:0032331)2.54950696
86folic acid-containing compound biosynthetic process (GO:0009396)2.54881326
87DNA strand elongation involved in DNA replication (GO:0006271)2.54084237
88regulation of catenin import into nucleus (GO:0035412)2.53954660
89mitotic metaphase plate congression (GO:0007080)2.53388022
90endocardial cushion development (GO:0003197)2.53194278
91* establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.52617013
92gastrulation with mouth forming second (GO:0001702)2.52030850
93DNA topological change (GO:0006265)2.52022287
94* establishment or maintenance of monopolar cell polarity (GO:0061339)2.51536338
95* establishment of monopolar cell polarity (GO:0061162)2.51536338
96regulation of tight junction assembly (GO:2000810)2.50649630
97nodal signaling pathway (GO:0038092)2.50586049
98cell adhesion mediated by integrin (GO:0033627)2.49345575
99regulation of nucleobase-containing compound transport (GO:0032239)2.48924190
100histone exchange (GO:0043486)2.48587887
101protein localization to cell surface (GO:0034394)2.48074980
102cell fate commitment involved in formation of primary germ layer (GO:0060795)2.47779508
103L-serine metabolic process (GO:0006563)2.47715222
104DNA replication-independent nucleosome organization (GO:0034724)2.47587025
105DNA replication-independent nucleosome assembly (GO:0006336)2.47587025
106cytoplasmic mRNA processing body assembly (GO:0033962)2.46951952
107positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.46929675
108positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.46929675
109positive regulation of mitotic sister chromatid separation (GO:1901970)2.46929675
110mesenchyme development (GO:0060485)2.46233078
111DNA duplex unwinding (GO:0032508)2.46134360
112DNA geometric change (GO:0032392)2.45234938
113cell migration involved in sprouting angiogenesis (GO:0002042)2.44671512
114peptidyl-arginine omega-N-methylation (GO:0035247)2.44509617
115mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.44041857
116positive regulation of cell cycle G2/M phase transition (GO:1902751)2.43936004
117positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.43936004
118DNA strand elongation (GO:0022616)2.42825298
119peptidyl-arginine methylation (GO:0018216)2.42614357
120peptidyl-arginine N-methylation (GO:0035246)2.42614357
121regulation of histone H3-K9 methylation (GO:0051570)2.42588094
122regulation of centrosome cycle (GO:0046605)2.42212027
123branching involved in prostate gland morphogenesis (GO:0060442)2.41937093
124ectoderm development (GO:0007398)2.41889969
125spindle checkpoint (GO:0031577)2.41666415
126regulation of helicase activity (GO:0051095)2.41612505
127embryonic process involved in female pregnancy (GO:0060136)2.41608699
128wound healing, spreading of epidermal cells (GO:0035313)2.41456960
129establishment of chromosome localization (GO:0051303)2.41439030
130dosage compensation (GO:0007549)2.41316866
131positive regulation of chromosome segregation (GO:0051984)2.40925193
132mitotic chromosome condensation (GO:0007076)2.40510597
133embryonic camera-type eye development (GO:0031076)2.40398818
134RNA stabilization (GO:0043489)2.39279562
135nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.35627342
136mitotic cytokinesis (GO:0000281)2.34036681
137negative regulation of chromosome segregation (GO:0051985)2.33179378
138convergent extension (GO:0060026)2.32287774
139negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.31185602
140negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.31185602
141negative regulation of mitotic sister chromatid segregation (GO:0033048)2.31185602
142negative regulation of mitotic sister chromatid separation (GO:2000816)2.31185602
143negative regulation of sister chromatid segregation (GO:0033046)2.31185602
144negative regulation of fibroblast apoptotic process (GO:2000270)2.30026791
145DNA replication initiation (GO:0006270)2.29926917
146mitotic spindle checkpoint (GO:0071174)2.27688286
147histone H2B ubiquitination (GO:0033523)2.27131386
148protein export from nucleus (GO:0006611)2.25661898
149response to X-ray (GO:0010165)2.25489822
150regulation of DNA endoreduplication (GO:0032875)2.24420014
151G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.23872606
152regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.23508276

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.90079435
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.84799180
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.19276010
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.80258321
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.32588126
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.74295258
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.74295258
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.74295258
9NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.72405059
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.64358944
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.63556000
12ESR1_15608294_ChIP-ChIP_MCF-7_Human2.60849927
13* SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.59093198
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.57307045
15POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.54926449
16AR_21909140_ChIP-Seq_LNCAP_Human2.48894530
17SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.45271668
18ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.44121712
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.32893063
20SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.29638685
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.25890028
22* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.24464771
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.23817204
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.04169100
25ZNF263_19887448_ChIP-Seq_K562_Human2.04069218
26HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.02156504
27MYC_18555785_ChIP-Seq_MESCs_Mouse2.01023798
28PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.00320854
29* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.94686872
30SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.93295938
31* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.84710226
32NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.83362379
33* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.82540013
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.82356118
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.81365556
36HIF1A_21447827_ChIP-Seq_MCF-7_Human1.79273075
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.77014675
38NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.76082814
39CLOCK_20551151_ChIP-Seq_293T_Human1.74390106
40TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.65915393
41SOX2_18555785_ChIP-Seq_MESCs_Mouse1.62040808
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61653444
43ELK1_19687146_ChIP-ChIP_HELA_Human1.60695878
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.57293657
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53112274
46ZFP281_27345836_Chip-Seq_ESCs_Mouse1.52836853
47SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.52102434
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.51792274
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51753039
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50218988
51KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.48500836
52NANOG_16153702_ChIP-ChIP_HESCs_Human1.47956247
53SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.47888231
54SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.47888231
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.47012757
56FOXO3_23340844_ChIP-Seq_DLD1_Human1.45853979
57* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.44764731
58KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.41708385
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.40160036
60ATF3_27146783_Chip-Seq_COLON_Human1.40032525
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39307926
62TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.38346420
63* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.37880501
64NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36717897
65EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.36353486
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.36070826
67FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.34145813
68MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.32084656
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31521195
70POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.30534591
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30072725
72SOX17_20123909_ChIP-Seq_XEN_Mouse1.29308263
73SOX2_16153702_ChIP-ChIP_HESCs_Human1.29087205
74CHD1_26751641_Chip-Seq_LNCaP_Human1.29037983
75* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.27960926
76FUS_26573619_Chip-Seq_HEK293_Human1.26753041
77EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.26164143
78* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.24674393
79HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.24121025
80POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23619627
81BRD4_25478319_ChIP-Seq_HGPS_Human1.23278135
82KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.22674038
83NANOG_21062744_ChIP-ChIP_HESCs_Human1.22602932
84ESR2_21235772_ChIP-Seq_MCF-7_Human1.21477819
85* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.20560283
86TP63_19390658_ChIP-ChIP_HaCaT_Human1.19642230
87RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19627882
88RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18946470
89* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.18015536
90* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.16972511
91ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16634861
92KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16447542
93P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15303461
94MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15075793
95* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.14877573
96SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14686564
97DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14551251
98PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.13225781
99MYC_19030024_ChIP-ChIP_MESCs_Mouse1.12405179
100CREB1_15753290_ChIP-ChIP_HEK293T_Human1.12324880
101* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12105039
102PKCTHETA_26484144_Chip-Seq_BREAST_Human1.11330283
103FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.09831573
104GATA6_25053715_ChIP-Seq_YYC3_Human1.08285165
105* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07731980
106CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07716047
107NANOG_16518401_ChIP-PET_MESCs_Mouse1.07274207
108* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.06560170
109MYC_18358816_ChIP-ChIP_MESCs_Mouse1.06495292
110POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06056728
111PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05988680
112FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04897328
113EWS_26573619_Chip-Seq_HEK293_Human1.04425825
114* ISL1_27105846_Chip-Seq_CPCs_Mouse1.04274044
115KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03978458
116ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03482072
117TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03460425
118* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.02922628
119TP53_16413492_ChIP-PET_HCT116_Human1.02804671
120* RUNX1_27514584_Chip-Seq_MCF-7_Human1.00920364
121TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.00002843
122TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99360140
123NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.99116385
124WT1_19549856_ChIP-ChIP_CCG9911_Human0.99056357
125CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98321212
126MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98250578
127TTF2_22483619_ChIP-Seq_HELA_Human0.98186606
128TBX3_20139965_ChIP-Seq_MESCs_Mouse0.97766546
129XRN2_22483619_ChIP-Seq_HELA_Human0.96472357
130HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95904968
131CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95533347
132MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92301757
133* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91294523
134TCF4_18268006_ChIP-ChIP_LS174T_Human0.89708256
135GATA1_26923725_Chip-Seq_HPCs_Mouse0.88009431
136* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.86282110
137RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.84478995

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.09632035
2MP0003705_abnormal_hypodermis_morpholog3.49913847
3MP0000537_abnormal_urethra_morphology3.24733721
4MP0010352_gastrointestinal_tract_polyps3.20322923
5MP0003941_abnormal_skin_development2.80846443
6MP0005623_abnormal_meninges_morphology2.64192606
7MP0005275_abnormal_skin_tensile2.43292220
8MP0009053_abnormal_anal_canal2.35633552
9MP0005076_abnormal_cell_differentiation2.24400997
10MP0010030_abnormal_orbit_morphology2.18432733
11MP0003123_paternal_imprinting2.18317444
12MP0003566_abnormal_cell_adhesion2.14097333
13MP0004272_abnormal_basement_membrane2.12918041
14MP0004957_abnormal_blastocyst_morpholog1.99621918
15MP0002796_impaired_skin_barrier1.91300822
16MP0008438_abnormal_cutaneous_collagen1.87145210
17MP0010678_abnormal_skin_adnexa1.82129974
18MP0005367_renal/urinary_system_phenotyp1.77393396
19MP0000516_abnormal_urinary_system1.77393396
20MP0002084_abnormal_developmental_patter1.76769776
21MP0009672_abnormal_birth_weight1.70332181
22MP0003283_abnormal_digestive_organ1.69998491
23MP0004197_abnormal_fetal_growth/weight/1.69333450
24MP0003119_abnormal_digestive_system1.68446728
25MP0000566_synostosis1.64136733
26MP0001849_ear_inflammation1.63407274
27MP0003937_abnormal_limbs/digits/tail_de1.62635586
28MP0009697_abnormal_copulation1.59930962
29MP0003890_abnormal_embryonic-extraembry1.58668228
30MP0001730_embryonic_growth_arrest1.56661238
31MP0002254_reproductive_system_inflammat1.55006774
32MP0003111_abnormal_nucleus_morphology1.52783851
33MP0002085_abnormal_embryonic_tissue1.52117761
34MP0002086_abnormal_extraembryonic_tissu1.47950460
35MP0002877_abnormal_melanocyte_morpholog1.45856993
36MP0000762_abnormal_tongue_morphology1.45671558
37MP0000350_abnormal_cell_proliferation1.44734717
38MP0003385_abnormal_body_wall1.43766841
39MP0004264_abnormal_extraembryonic_tissu1.43636833
40MP0005501_abnormal_skin_physiology1.42120739
41MP0003755_abnormal_palate_morphology1.39990299
42MP0003115_abnormal_respiratory_system1.39311038
43MP0002009_preneoplasia1.39146184
44MP0005380_embryogenesis_phenotype1.38647831
45MP0001672_abnormal_embryogenesis/_devel1.38647831
46MP0000534_abnormal_ureter_morphology1.38065177
47MP0003693_abnormal_embryo_hatching1.37359353
48MP0003077_abnormal_cell_cycle1.36499142
49MP0003121_genomic_imprinting1.36025775
50MP0010094_abnormal_chromosome_stability1.35724264
51MP0005248_abnormal_Harderian_gland1.35320601
52MP0010307_abnormal_tumor_latency1.34594652
53MP0005023_abnormal_wound_healing1.31602566
54MP0000383_abnormal_hair_follicle1.31276071
55MP0000428_abnormal_craniofacial_morphol1.30144911
56MP0008058_abnormal_DNA_repair1.29462917
57MP0003091_abnormal_cell_migration1.28070435
58MP0001188_hyperpigmentation1.27819701
59MP0001697_abnormal_embryo_size1.27214859
60MP0003984_embryonic_growth_retardation1.27006272
61MP0002088_abnormal_embryonic_growth/wei1.26834251
62MP0003935_abnormal_craniofacial_develop1.25510200
63MP0000432_abnormal_head_morphology1.25201845
64MP0002060_abnormal_skin_morphology1.24103554
65MP0003942_abnormal_urinary_system1.23893415
66MP0000467_abnormal_esophagus_morphology1.23889552
67MP0001293_anophthalmia1.23502833
68MP0002111_abnormal_tail_morphology1.23116780
69MP0003453_abnormal_keratinocyte_physiol1.19871415
70MP0004133_heterotaxia1.18875665
71* MP0002697_abnormal_eye_size1.18300596
72MP0002653_abnormal_ependyma_morphology1.17818064
73MP0002282_abnormal_trachea_morphology1.16628856
74MP0005187_abnormal_penis_morphology1.15813237
75MP0000733_abnormal_muscle_development1.15405656
76MP0003567_abnormal_fetal_cardiomyocyte1.14616334
77MP0003950_abnormal_plasma_membrane1.13873674
78MP0008932_abnormal_embryonic_tissue1.12637200
79MP0002092_abnormal_eye_morphology1.09780959
80MP0000579_abnormal_nail_morphology1.08876575
81MP0002098_abnormal_vibrissa_morphology1.07875719
82MP0002233_abnormal_nose_morphology1.06625989
83MP0001177_atelectasis1.06260596
84MP0009384_cardiac_valve_regurgitation1.05601056
85MP0001299_abnormal_eye_distance/1.03310285
86MP0001286_abnormal_eye_development1.02567805
87MP0003718_maternal_effect1.01713510
88MP0005257_abnormal_intraocular_pressure1.00661550
89MP0005503_abnormal_tendon_morphology1.00483028
90* MP0002080_prenatal_lethality0.99865561
91MP0000377_abnormal_hair_follicle0.98451985
92MP0000627_abnormal_mammary_gland0.98286121
93MP0005508_abnormal_skeleton_morphology0.95198990
94MP0000647_abnormal_sebaceous_gland0.94668813
95MP0009703_decreased_birth_body0.94515566
96MP0002925_abnormal_cardiovascular_devel0.93820790
97MP0004233_abnormal_muscle_weight0.93264817
98MP0001216_abnormal_epidermal_layer0.92572999
99MP0002932_abnormal_joint_morphology0.91814187
100MP0000462_abnormal_digestive_system0.91211748
101MP0002234_abnormal_pharynx_morphology0.90820986
102MP0008007_abnormal_cellular_replicative0.90428718
103MP0000427_abnormal_hair_cycle0.90219324
104MP0002249_abnormal_larynx_morphology0.88851936
105* MP0003861_abnormal_nervous_system0.88723429
106MP0001958_emphysema0.88307852
107MP0008057_abnormal_DNA_replication0.88111393
108MP0002896_abnormal_bone_mineralization0.87318568
109MP0003936_abnormal_reproductive_system0.87061265
110MP0010771_integument_phenotype0.85800398
111MP0003315_abnormal_perineum_morphology0.85718046
112MP0006054_spinal_hemorrhage0.85429969
113MP0005409_darkened_coat_color0.84311260
114MP0004782_abnormal_surfactant_physiolog0.82529067
115MP0001915_intracranial_hemorrhage0.82117806
116MP0009250_abnormal_appendicular_skeleto0.81593471
117MP0002081_perinatal_lethality0.78456318
118MP0001340_abnormal_eyelid_morphology0.75951909
119MP0009780_abnormal_chondrocyte_physiolo0.72530272

Predicted human phenotypes

RankGene SetZ-score
1Shallow orbits (HP:0000586)3.29928874
2Ependymoma (HP:0002888)2.95288947
3Ankle contracture (HP:0006466)2.92413160
4Abnormality of the astrocytes (HP:0100707)2.86059580
5Astrocytoma (HP:0009592)2.86059580
6Atrophic scars (HP:0001075)2.85096700
7Protrusio acetabuli (HP:0003179)2.83112919
8Colon cancer (HP:0003003)2.76521602
9Selective tooth agenesis (HP:0001592)2.71226950
10Biliary tract neoplasm (HP:0100574)2.68382135
11Cortical dysplasia (HP:0002539)2.65885757
12Abnormality of the labia minora (HP:0012880)2.59879937
13Short humerus (HP:0005792)2.48528370
14Insidious onset (HP:0003587)2.46923895
15Termporal pattern (HP:0011008)2.46923895
16Milia (HP:0001056)2.45406210
17Nephroblastoma (Wilms tumor) (HP:0002667)2.39925167
18Deviation of the thumb (HP:0009603)2.39756118
19Short 4th metacarpal (HP:0010044)2.39012364
20Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.39012364
21Chromosomal breakage induced by crosslinking agents (HP:0003221)2.38339990
22Chromsome breakage (HP:0040012)2.34711776
23Embryonal renal neoplasm (HP:0011794)2.34504971
24Ankyloglossia (HP:0010296)2.33535554
25Esophageal atresia (HP:0002032)2.32908571
26Right ventricular cardiomyopathy (HP:0011663)2.32437260
27Papillary thyroid carcinoma (HP:0002895)2.31474330
28Aplasia/hypoplasia of the humerus (HP:0006507)2.31459388
29Premature rupture of membranes (HP:0001788)2.30884249
30Missing ribs (HP:0000921)2.30393954
31Cerebral aneurysm (HP:0004944)2.29876315
32Rectal prolapse (HP:0002035)2.28675868
33Glioma (HP:0009733)2.24000459
34Gastrointestinal carcinoma (HP:0002672)2.22371296
35Malignant gastrointestinal tract tumors (HP:0006749)2.22371296
36Shawl scrotum (HP:0000049)2.21105334
37Proximal placement of thumb (HP:0009623)2.19061315
38Facial cleft (HP:0002006)2.11728780
39Broad thumb (HP:0011304)2.08140925
40Deep philtrum (HP:0002002)2.07658843
41Fused cervical vertebrae (HP:0002949)2.03437560
42Subacute progressive viral hepatitis (HP:0006572)2.02637912
43Pterygium (HP:0001059)2.01568131
44Vertebral arch anomaly (HP:0008438)2.01416347
45Hypoplastic labia majora (HP:0000059)1.98646250
46Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.97588846
47Short 1st metacarpal (HP:0010034)1.97588846
48Ulnar bowing (HP:0003031)1.97546440
49Abnormality of oral frenula (HP:0000190)1.96869706
50Genu recurvatum (HP:0002816)1.96674311
51High anterior hairline (HP:0009890)1.94590982
52Neoplasm of the oral cavity (HP:0100649)1.94000460
53Bronchomalacia (HP:0002780)1.93711422
54Absent eyelashes (HP:0000561)1.92927155
55Fragile nails (HP:0001808)1.91856883
56Curly hair (HP:0002212)1.90057978
57Coronal craniosynostosis (HP:0004440)1.88912635
58Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.87614830
59Abnormality of the distal phalanx of the thumb (HP:0009617)1.87090761
60Advanced eruption of teeth (HP:0006288)1.86530562
61Abnormality of the nasal septum (HP:0000419)1.85999707
62Spastic diplegia (HP:0001264)1.85341350
63Abnormal lung lobation (HP:0002101)1.84101854
64Overriding aorta (HP:0002623)1.83924931
65Absent eyebrow (HP:0002223)1.83876049
66Wrist flexion contracture (HP:0001239)1.83691026
67Hepatoblastoma (HP:0002884)1.83161501
68Mitral valve prolapse (HP:0001634)1.82183439
69Medulloblastoma (HP:0002885)1.82155168
70Pili torti (HP:0003777)1.81769393
71Arnold-Chiari malformation (HP:0002308)1.81703966
72Natal tooth (HP:0000695)1.81605051
73Abnormality of the 4th metacarpal (HP:0010012)1.80826060
74Abnormality of nail color (HP:0100643)1.79178754
75Woolly hair (HP:0002224)1.78680565
76Radial bowing (HP:0002986)1.77382737
77Uterine neoplasm (HP:0010784)1.76985047
78Abnormality of the labia majora (HP:0012881)1.76722207
79Abnormality of the salivary glands (HP:0010286)1.74951573
80Syringomyelia (HP:0003396)1.74870850
81Spinal cord lesions (HP:0100561)1.74870850
82Myelomeningocele (HP:0002475)1.73832416
83Arterial tortuosity (HP:0005116)1.73638481
84Aortic aneurysm (HP:0004942)1.73447704
85Abnormality of the proximal phalanges of the hand (HP:0009834)1.71705484
86Synostosis of carpal bones (HP:0005048)1.70083237
87Asymmetry of the thorax (HP:0001555)1.69514820
88Abnormality of the calcaneus (HP:0008364)1.69060337
89Leiomyosarcoma (HP:0100243)1.68531639
90Uterine leiomyosarcoma (HP:0002891)1.68531639
91Rhabdomyosarcoma (HP:0002859)1.67781550
92Abnormality of the 1st metacarpal (HP:0010009)1.67060362
93Stenosis of the external auditory canal (HP:0000402)1.65268598
94Dilatation of the ascending aorta (HP:0005111)1.64486671
95Thyroid carcinoma (HP:0002890)1.64421808
96Broad phalanges of the hand (HP:0009768)1.64038346
97Urethral obstruction (HP:0000796)1.63284862
98Renal duplication (HP:0000075)1.62746274
99Absent radius (HP:0003974)1.62653095
100Abnormality of the 2nd finger (HP:0004100)1.62624227
101Aplasia/Hypoplasia of the sternum (HP:0006714)1.62467832
102Bowel diverticulosis (HP:0005222)1.62313190
103Onycholysis (HP:0001806)1.61502876
104Deviation of the hallux (HP:0010051)1.61267267
105Short phalanx of the thumb (HP:0009660)1.60897978
106Fibroma (HP:0010614)1.60645562
107Fragile skin (HP:0001030)1.59808973
108Cutaneous syndactyly (HP:0012725)1.59157907
109Broad finger (HP:0001500)1.59042857
110Bifid tongue (HP:0010297)1.58576322
111Abnormality of chromosome stability (HP:0003220)1.58487784
112Supernumerary ribs (HP:0005815)1.58246897
113Hyperacusis (HP:0010780)1.58134365
114Increased connective tissue (HP:0009025)1.58084805
115Sandal gap (HP:0001852)1.58004823
116Increased nuchal translucency (HP:0010880)1.57075225
117Fibrous tissue neoplasm (HP:0012316)1.56873594
118Acute myeloid leukemia (HP:0004808)1.56667831
119Gastrointestinal atresia (HP:0002589)1.56623483
120Cervical subluxation (HP:0003308)1.56345542
121Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.56068090
122Heterotopia (HP:0002282)1.56067173
123Volvulus (HP:0002580)1.56032359
124Broad long bones (HP:0005622)1.55953030
125Aplasia involving forearm bones (HP:0009822)1.55583419
126Absent forearm bone (HP:0003953)1.55583419
127Neoplasm of striated muscle (HP:0009728)1.55097377
128Hand muscle atrophy (HP:0009130)1.54602542
129Breast carcinoma (HP:0003002)1.54565372
130Abnormal biliary tract morphology (HP:0012440)1.54477830
131Omphalocele (HP:0001539)1.54330808
132Transitional cell carcinoma of the bladder (HP:0006740)1.54274882
133Buphthalmos (HP:0000557)1.54077500
134Abnormality of the antihelix (HP:0009738)1.53945179
135Choanal stenosis (HP:0000452)1.53943745
136Cutaneous finger syndactyly (HP:0010554)1.53842626
137Neoplasm of the small intestine (HP:0100833)1.53447100
138Broad phalanx (HP:0006009)1.52803228
139Aplasia involving bones of the upper limbs (HP:0009823)1.52656164
140Aplasia of the phalanges of the hand (HP:0009802)1.52656164
141Aplasia involving bones of the extremities (HP:0009825)1.52656164
142Birth length less than 3rd percentile (HP:0003561)1.52473144
143Upper limb amyotrophy (HP:0009129)1.52116496
144Distal upper limb amyotrophy (HP:0007149)1.52116496
145Short hallux (HP:0010109)1.51641794
146Meckel diverticulum (HP:0002245)1.51554200
147Hallux valgus (HP:0001822)1.51129456
148Hypoplastic toenails (HP:0001800)1.50323583
149Abnormality of the lacrimal duct (HP:0011481)1.50216260
150Duplication of thumb phalanx (HP:0009942)1.50158242
151Abnormality of the septum pellucidum (HP:0007375)1.49500170
152Vascular tortuosity (HP:0004948)1.48909982
153Partial agenesis of the corpus callosum (HP:0001338)1.48812031
154Diastasis recti (HP:0001540)1.47204850
155Shoulder girdle muscle weakness (HP:0003547)1.46616315
156Overgrowth (HP:0001548)1.46331073
157Short middle phalanx of the 5th finger (HP:0004220)1.45665736
158Microglossia (HP:0000171)1.45434013
159Multiple enchondromatosis (HP:0005701)1.44798652
160Bladder carcinoma (HP:0002862)1.44262901
161Bladder neoplasm (HP:0009725)1.44262901

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.39741372
2LATS14.26897070
3CDK123.44813926
4LATS22.71015363
5PBK2.48933774
6EEF2K2.13585862
7CDC72.13287255
8RPS6KB22.12702518
9TTN1.99171597
10TTK1.93958901
11DDR21.91916675
12MKNK21.90092408
13PDGFRA1.89201322
14FER1.88895414
15STK38L1.85567509
16PKN21.84529408
17NEK11.79790650
18BUB11.71439734
19TAF11.69803665
20WEE11.65651298
21EIF2AK31.65313978
22STK31.58568371
23MET1.57880484
24SCYL21.55927333
25EIF2AK11.54339082
26TRIB31.48684591
27CASK1.47382166
28EPHB21.46081158
29NEK21.38283776
30CDK61.35240136
31PTK21.32836347
32MAP3K21.32779268
33FGFR11.29995479
34PAK41.29859258
35AKT31.29776809
36PAK21.29675413
37RIPK11.26743904
38PLK41.25820060
39STK241.24723762
40MAP3K91.22856667
41TNIK1.22055050
42MTOR1.21896497
43ALK1.20245469
44KSR21.19593254
45BMX1.19124453
46FRK1.15982640
47KSR11.14448702
48MAP3K81.14370120
49LRRK21.14038867
50BRD41.08773421
51FGFR21.07899339
52PTK61.07192196
53PLK31.06199134
54PNCK1.03513640
55STK101.01282226
56CDK70.97849350
57YES10.96486753
58BRSK10.91436815
59MAP3K120.90643515
60AURKB0.89821907
61PLK10.89645929
62TYRO30.88669511
63EIF2AK20.86742705
64TGFBR10.86179608
65PRKCI0.85536494
66CAMK1D0.85500747
67TRIM280.85178193
68MAP3K100.82959317
69ZAK0.81578648
70MST40.81559420
71TSSK60.81376576
72MELK0.80386541
73CHEK20.78565977
74CHEK10.78334636
75STK390.77986771
76PDGFRB0.77336284
77ERBB40.77200408
78PAK30.74981770
79FLT30.74864801
80STK380.74348632
81CSNK1E0.72624120
82MST1R0.72610390
83CDK40.72136790
84MAPKAPK30.70307876
85BRSK20.69556988
86DMPK0.68559732
87ICK0.67042694
88ATM0.64839209
89RPS6KA40.64241960
90CDK20.63452999
91PRKD30.63399163
92CSNK1D0.62806371
93SMG10.62327653
94RET0.62214864
95TESK10.62084034
96ATR0.61112579
97DYRK30.59890790
98BRAF0.58651890
99PASK0.58265860
100AURKA0.58089460
101BCR0.58078094
102MAP3K30.57642301
103MAP2K10.57360446
104ERBB30.56641965
105PAK60.56034564
106LMTK20.53970340
107AKT20.52068234
108ERBB20.50420314
109MKNK10.50075298
110CDK10.48115904
111ACVR1B0.48114520
112MAP3K40.47631119
113SIK10.47159239
114PRKDC0.46508121
115PLK20.44984105
116STK40.43589115
117CDK180.40543556
118CAMK1G0.39554496
119SRPK10.39280026
120WNK10.37036192
121ROCK10.36909978
122CDK150.35466252
123NTRK10.35077192
124CLK10.34515746
125NEK60.34367172
126CSNK1G10.34338890
127MAPK140.34051756
128LIMK10.33658390
129DYRK20.33124344
130WNK30.32933284
131CDK90.32641948

Predicted pathways (KEGG)

RankGene SetZ-score
1Adherens junction_Homo sapiens_hsa045202.68193668
2* Hippo signaling pathway_Homo sapiens_hsa043902.67884121
3Basal cell carcinoma_Homo sapiens_hsa052172.30066291
4ECM-receptor interaction_Homo sapiens_hsa045122.20976913
5Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.15439804
6RNA transport_Homo sapiens_hsa030132.07359151
7TGF-beta signaling pathway_Homo sapiens_hsa043502.05555157
8Bladder cancer_Homo sapiens_hsa052191.98788374
9MicroRNAs in cancer_Homo sapiens_hsa052061.96321570
10* Tight junction_Homo sapiens_hsa045301.94571879
11Cell cycle_Homo sapiens_hsa041101.93131181
12Proteoglycans in cancer_Homo sapiens_hsa052051.92019306
13Small cell lung cancer_Homo sapiens_hsa052221.86411419
14Hedgehog signaling pathway_Homo sapiens_hsa043401.83482826
15Focal adhesion_Homo sapiens_hsa045101.81569426
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.75627992
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.72089286
18One carbon pool by folate_Homo sapiens_hsa006701.61980748
19mRNA surveillance pathway_Homo sapiens_hsa030151.56544325
20Thyroid cancer_Homo sapiens_hsa052161.56511415
21p53 signaling pathway_Homo sapiens_hsa041151.49318301
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.47966525
23Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.47678672
24Endometrial cancer_Homo sapiens_hsa052131.47460501
25Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.46161853
26Oocyte meiosis_Homo sapiens_hsa041141.45124775
27Mismatch repair_Homo sapiens_hsa034301.39279765
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.38917785
29Wnt signaling pathway_Homo sapiens_hsa043101.37673295
30Basal transcription factors_Homo sapiens_hsa030221.36282168
31mTOR signaling pathway_Homo sapiens_hsa041501.36239501
32Colorectal cancer_Homo sapiens_hsa052101.35659214
33Melanoma_Homo sapiens_hsa052181.28615224
34Dorso-ventral axis formation_Homo sapiens_hsa043201.28078532
35Glioma_Homo sapiens_hsa052141.26537153
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.26043734
37Biosynthesis of amino acids_Homo sapiens_hsa012301.22500649
38Chronic myeloid leukemia_Homo sapiens_hsa052201.22450022
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22071351
40Spliceosome_Homo sapiens_hsa030401.19504381
41Nitrogen metabolism_Homo sapiens_hsa009101.19264392
42Steroid biosynthesis_Homo sapiens_hsa001001.19119086
43Amoebiasis_Homo sapiens_hsa051461.18949549
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.18917656
45Pathways in cancer_Homo sapiens_hsa052001.18582054
46Central carbon metabolism in cancer_Homo sapiens_hsa052301.18507677
47Melanogenesis_Homo sapiens_hsa049161.17338707
48Viral carcinogenesis_Homo sapiens_hsa052031.14855585
49Prostate cancer_Homo sapiens_hsa052151.13315745
50Regulation of actin cytoskeleton_Homo sapiens_hsa048101.13134040
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.11117890
52Renal cell carcinoma_Homo sapiens_hsa052111.08975649
53Estrogen signaling pathway_Homo sapiens_hsa049151.08300250
54Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05388589
55Axon guidance_Homo sapiens_hsa043601.05086696
56Vitamin B6 metabolism_Homo sapiens_hsa007501.02994728
57Pyruvate metabolism_Homo sapiens_hsa006201.02133802
58Base excision repair_Homo sapiens_hsa034101.01307269
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00905941
60HTLV-I infection_Homo sapiens_hsa051660.99187704
61ErbB signaling pathway_Homo sapiens_hsa040120.98430933
62DNA replication_Homo sapiens_hsa030300.96822418
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95570707
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94892067
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94401952
66* Rap1 signaling pathway_Homo sapiens_hsa040150.93641245
67Pancreatic cancer_Homo sapiens_hsa052120.91686503
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.89035360
69Homologous recombination_Homo sapiens_hsa034400.88553557
70PI3K-Akt signaling pathway_Homo sapiens_hsa041510.88174204
71Nucleotide excision repair_Homo sapiens_hsa034200.87951540
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87733711
73Non-small cell lung cancer_Homo sapiens_hsa052230.87182206
74Systemic lupus erythematosus_Homo sapiens_hsa053220.86592569
75Protein digestion and absorption_Homo sapiens_hsa049740.83528991
76Protein export_Homo sapiens_hsa030600.82391175
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82170631
78Gap junction_Homo sapiens_hsa045400.81726666
79Notch signaling pathway_Homo sapiens_hsa043300.80822862
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80302274
81Alcoholism_Homo sapiens_hsa050340.78537599
82Long-term potentiation_Homo sapiens_hsa047200.76007161
83Carbon metabolism_Homo sapiens_hsa012000.75325514
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72495692
85VEGF signaling pathway_Homo sapiens_hsa043700.71760039
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71591758
87GnRH signaling pathway_Homo sapiens_hsa049120.70707842
88RNA degradation_Homo sapiens_hsa030180.68077259
89FoxO signaling pathway_Homo sapiens_hsa040680.68060736
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66790926
91Proteasome_Homo sapiens_hsa030500.66344735
92AMPK signaling pathway_Homo sapiens_hsa041520.66177053
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.64851494
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64440453
95RNA polymerase_Homo sapiens_hsa030200.61204993
96Lysine degradation_Homo sapiens_hsa003100.60808293
97N-Glycan biosynthesis_Homo sapiens_hsa005100.60704599
98Pentose phosphate pathway_Homo sapiens_hsa000300.59286443
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57041200
100Propanoate metabolism_Homo sapiens_hsa006400.56586488
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56476592
102Dilated cardiomyopathy_Homo sapiens_hsa054140.56281602
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56145394
104Fatty acid biosynthesis_Homo sapiens_hsa000610.55174943
105HIF-1 signaling pathway_Homo sapiens_hsa040660.55091912
106Fanconi anemia pathway_Homo sapiens_hsa034600.53543767
107Thyroid hormone synthesis_Homo sapiens_hsa049180.53488449
108Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52567561
109Choline metabolism in cancer_Homo sapiens_hsa052310.51616173
110Pyrimidine metabolism_Homo sapiens_hsa002400.50371666
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49009943
112Ras signaling pathway_Homo sapiens_hsa040140.47596289
113Mineral absorption_Homo sapiens_hsa049780.45758313
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45361319
115Long-term depression_Homo sapiens_hsa047300.44924303
116Non-homologous end-joining_Homo sapiens_hsa034500.44684623
117Renin-angiotensin system_Homo sapiens_hsa046140.43709662
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42669175
119Inositol phosphate metabolism_Homo sapiens_hsa005620.41612706
120* Insulin signaling pathway_Homo sapiens_hsa049100.40999665
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.40678316
122Sulfur metabolism_Homo sapiens_hsa009200.40559445
123Acute myeloid leukemia_Homo sapiens_hsa052210.40552042
124Oxytocin signaling pathway_Homo sapiens_hsa049210.40168012
125MAPK signaling pathway_Homo sapiens_hsa040100.39471360
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39429338
127Circadian rhythm_Homo sapiens_hsa047100.39344858
128Selenocompound metabolism_Homo sapiens_hsa004500.39285486
129Cyanoamino acid metabolism_Homo sapiens_hsa004600.39123095
130Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37861059
131Purine metabolism_Homo sapiens_hsa002300.36824334
132Glucagon signaling pathway_Homo sapiens_hsa049220.35855085

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