PRKCQ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.72386132
2myelination (GO:0042552)7.36767573
3ensheathment of neurons (GO:0007272)7.35373562
4axon ensheathment (GO:0008366)7.35373562
5long-chain fatty acid biosynthetic process (GO:0042759)6.50842325
6activated T cell proliferation (GO:0050798)6.41067881
7positive regulation of gamma-delta T cell activation (GO:0046645)6.28551522
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.84231463
9regulation of gamma-delta T cell differentiation (GO:0045586)5.80952939
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.78674884
11negative regulation of cell killing (GO:0031342)5.78674884
12negative T cell selection (GO:0043383)5.72881527
13negative regulation of neurotransmitter secretion (GO:0046929)5.60047861
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.48827303
15cholesterol biosynthetic process (GO:0006695)5.33416314
16actin-myosin filament sliding (GO:0033275)5.32977919
17muscle filament sliding (GO:0030049)5.32977919
18negative thymic T cell selection (GO:0045060)5.24292420
19positive T cell selection (GO:0043368)5.20208858
20oligodendrocyte differentiation (GO:0048709)5.10748731
21sarcoplasmic reticulum calcium ion transport (GO:0070296)5.07975957
22L-amino acid import (GO:0043092)5.05235646
23regulation of gamma-delta T cell activation (GO:0046643)5.05204294
24regulation of B cell receptor signaling pathway (GO:0050855)5.05165414
25glycerophospholipid catabolic process (GO:0046475)5.00400181
26regulation of collateral sprouting (GO:0048670)4.91855093
27positive thymic T cell selection (GO:0045059)4.91569414
28response to interleukin-15 (GO:0070672)4.82458449
29negative regulation of neurotransmitter transport (GO:0051589)4.74782757
30response to redox state (GO:0051775)4.68423065
31positive regulation of granulocyte differentiation (GO:0030854)4.64481316
32sterol biosynthetic process (GO:0016126)4.59573918
33regulation of skeletal muscle contraction (GO:0014819)4.53516691
34skeletal muscle contraction (GO:0003009)4.50213957
35eye photoreceptor cell differentiation (GO:0001754)4.48071370
36photoreceptor cell differentiation (GO:0046530)4.48071370
37creatine metabolic process (GO:0006600)4.46399901
38thymic T cell selection (GO:0045061)4.44305831
39cellular response to interleukin-15 (GO:0071350)4.42609260
40antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.42040451
41negative regulation of protein localization to cell surface (GO:2000009)4.39792489
42T cell selection (GO:0045058)4.37320970
43isoprenoid biosynthetic process (GO:0008299)4.33275872
44amino acid import (GO:0043090)4.32731633
45positive regulation of B cell differentiation (GO:0045579)4.27363494
46myelin maintenance (GO:0043217)4.19511397
47asymmetric protein localization (GO:0008105)4.19372480
48T cell migration (GO:0072678)4.14877781
49presynaptic membrane assembly (GO:0097105)4.14235945
50actin-mediated cell contraction (GO:0070252)4.14047628
51regulation of regulatory T cell differentiation (GO:0045589)4.11968761
52presynaptic membrane organization (GO:0097090)4.11595951
53cytidine metabolic process (GO:0046087)4.09260760
54cytidine catabolic process (GO:0006216)4.09260760
55cytidine deamination (GO:0009972)4.09260760
56regulation of relaxation of muscle (GO:1901077)4.08744990
57substantia nigra development (GO:0021762)4.08677988
58virion attachment to host cell (GO:0019062)4.07337442
59adhesion of symbiont to host cell (GO:0044650)4.07337442
60negative regulation of T cell mediated immunity (GO:0002710)4.05363066
61antigen processing and presentation of endogenous antigen (GO:0019883)4.01673864
62positive regulation of oligodendrocyte differentiation (GO:0048714)3.98815359
63* positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.94179286
64Peyers patch development (GO:0048541)3.91432052
65mucosal-associated lymphoid tissue development (GO:0048537)3.91432052
66neuron cell-cell adhesion (GO:0007158)3.88818718
67antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.87634477
68regulation of alpha-beta T cell proliferation (GO:0046640)3.85351363
69positive regulation of alpha-beta T cell proliferation (GO:0046641)3.82480470
70regulation of B cell differentiation (GO:0045577)3.80653859
71peripheral nervous system axon ensheathment (GO:0032292)3.79477730
72myelination in peripheral nervous system (GO:0022011)3.79477730
73negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.77715518
74astrocyte development (GO:0014002)3.77006139
75pyrimidine ribonucleoside catabolic process (GO:0046133)3.70704739
76response to methylmercury (GO:0051597)3.70669732
77histone H2B ubiquitination (GO:0033523)3.67954662
78apical protein localization (GO:0045176)3.67173188
79negative regulation of lymphocyte mediated immunity (GO:0002707)3.61928270
80establishment of mitochondrion localization (GO:0051654)3.59123700
81tolerance induction (GO:0002507)3.58756999
82transmission of nerve impulse (GO:0019226)3.58546051
83positive regulation of action potential (GO:0045760)3.56395142
84protein palmitoylation (GO:0018345)3.54602939
85long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.49103970
86regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.45503142
87regulation of natural killer cell mediated immunity (GO:0002715)3.45503142
88regulation of T cell tolerance induction (GO:0002664)3.45495806
89amyloid precursor protein metabolic process (GO:0042982)3.44570048
90interferon-gamma production (GO:0032609)3.43712477
91positive regulation of tolerance induction (GO:0002645)3.43213496
92glycosylceramide metabolic process (GO:0006677)3.42788921
93negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.42641547
94regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.41906851
95membrane tubulation (GO:0097320)3.37846281
96GPI anchor biosynthetic process (GO:0006506)3.34722565
97B cell receptor signaling pathway (GO:0050853)3.34082337
98negative regulation of erythrocyte differentiation (GO:0045647)3.32730415
99response to lipoprotein particle (GO:0055094)3.30610337
100positive regulation of natural killer cell mediated immunity (GO:0002717)3.29960147
101regulation of T cell mediated cytotoxicity (GO:0001914)3.26709421
102import into cell (GO:0098657)3.24680830
103* T cell receptor signaling pathway (GO:0050852)3.23901263
104cellular response to epinephrine stimulus (GO:0071872)3.23747117
105preassembly of GPI anchor in ER membrane (GO:0016254)3.22016929
106* antigen receptor-mediated signaling pathway (GO:0050851)3.21403588
107megakaryocyte development (GO:0035855)3.20683647
108long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.20157072
109GPI anchor metabolic process (GO:0006505)3.19759998
110regulation of leukocyte mediated cytotoxicity (GO:0001910)3.16906465
111positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.16571986
112peptidyl-tyrosine autophosphorylation (GO:0038083)3.16475966
113negative regulation of axonogenesis (GO:0050771)3.16471871
114regulation of granulocyte differentiation (GO:0030852)3.14870599
115* negative regulation of T cell apoptotic process (GO:0070233)3.11634927
116negative regulation of leukocyte mediated immunity (GO:0002704)3.11524977
117mast cell activation (GO:0045576)3.09115402
118regulation of tolerance induction (GO:0002643)3.08105356
119negative regulation of axon extension (GO:0030517)3.07699780
120negative regulation of execution phase of apoptosis (GO:1900118)3.07090815
121positive regulation of T cell mediated cytotoxicity (GO:0001916)3.05834899
122actin filament-based movement (GO:0030048)3.05382317
123cerebral cortex radially oriented cell migration (GO:0021799)3.02644974
124T cell homeostasis (GO:0043029)3.01940956
125microtubule polymerization or depolymerization (GO:0031109)2.98396331
126regulation of necroptotic process (GO:0060544)2.98307392
127interleukin-6-mediated signaling pathway (GO:0070102)2.97744506
128magnesium ion transport (GO:0015693)2.95546314
129Arp2/3 complex-mediated actin nucleation (GO:0034314)2.95513037
130negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.94937998
131negative regulation of T-helper cell differentiation (GO:0045623)2.94937998
132positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.94564026
133skeletal muscle adaptation (GO:0043501)2.94522524
134* regulation of interleukin-2 biosynthetic process (GO:0045076)2.94434103
135fatty-acyl-CoA biosynthetic process (GO:0046949)2.93536968
136regulation of T cell receptor signaling pathway (GO:0050856)2.93406510
137negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.92779459
138peripheral nervous system development (GO:0007422)2.92110847
139negative regulation of JUN kinase activity (GO:0043508)2.91456421
140axon development (GO:0061564)2.90802544
141leukocyte migration involved in inflammatory response (GO:0002523)2.90672404
142negative regulation of interleukin-10 production (GO:0032693)2.90179649
143negative regulation of myoblast differentiation (GO:0045662)2.89182467
144limb bud formation (GO:0060174)2.87192732
145ear development (GO:0043583)2.87070071
146negative regulation of necroptotic process (GO:0060546)2.86707535
147positive regulation of glial cell differentiation (GO:0045687)2.86290174
148positive regulation of neurological system process (GO:0031646)2.85754370
149response to epinephrine (GO:0071871)2.83712801
150adhesion of symbiont to host (GO:0044406)2.83633081
151Leydig cell differentiation (GO:0033327)2.82482851
152regulation of cell killing (GO:0031341)2.82138726
153response to hepatocyte growth factor (GO:0035728)2.81687478
154cellular response to hepatocyte growth factor stimulus (GO:0035729)2.81687478
155skeletal muscle tissue regeneration (GO:0043403)2.81198210
156alpha-beta T cell differentiation (GO:0046632)2.80058387
157positive regulation of cell killing (GO:0031343)2.79569335
158striated muscle contraction (GO:0006941)2.79150649
159glial cell development (GO:0021782)2.78924345
160mannosylation (GO:0097502)2.78632527
161positive regulation of actin filament depolymerization (GO:0030836)2.77954649
162enteric nervous system development (GO:0048484)2.77671546
163negative regulation of adaptive immune response (GO:0002820)2.77150936
164negative regulation of stress fiber assembly (GO:0051497)2.76835808
165natural killer cell differentiation (GO:0001779)2.76701481
166T cell differentiation (GO:0030217)2.75766489
167nucleotide transmembrane transport (GO:1901679)2.75520117
168regulation of somitogenesis (GO:0014807)2.73710510
169alpha-beta T cell activation (GO:0046631)2.73182880
170adult walking behavior (GO:0007628)2.71288190
171positive regulation of gliogenesis (GO:0014015)2.71274817
172fatty-acyl-CoA metabolic process (GO:0035337)2.70300089
173myofibril assembly (GO:0030239)2.69080555
174purine nucleotide salvage (GO:0032261)2.68658466
175positive regulation of calcium-mediated signaling (GO:0050850)2.68646922
176regulation of isotype switching to IgG isotypes (GO:0048302)2.68583043
177neural nucleus development (GO:0048857)2.67253013
178pyrimidine nucleoside catabolic process (GO:0046135)2.66923070
179glial cell differentiation (GO:0010001)2.66661827
180positive regulation of cellular amine metabolic process (GO:0033240)2.66226083
181neuron remodeling (GO:0016322)2.64248239
182lymphocyte homeostasis (GO:0002260)2.64082310
183organ growth (GO:0035265)2.63727549
184regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.62632814
185positive regulation of natural killer cell differentiation (GO:0032825)2.62238892
186amyloid precursor protein catabolic process (GO:0042987)2.61200609
187positive regulation of T cell differentiation in thymus (GO:0033089)2.60020929
188negative regulation of acute inflammatory response (GO:0002674)2.59538835
189leukocyte degranulation (GO:0043299)2.59433861
190leukocyte aggregation (GO:0070486)2.58560619
191ceramide biosynthetic process (GO:0046513)2.57237120
192peptidyl-cysteine modification (GO:0018198)2.57120909
193fusion of sperm to egg plasma membrane (GO:0007342)2.55364027
194protein neddylation (GO:0045116)2.55001574
195central nervous system myelination (GO:0022010)11.1144830
196axon ensheathment in central nervous system (GO:0032291)11.1144830

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.53455426
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.84782955
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.29815096
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.66840082
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.51759758
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.48872914
7* MYB_26560356_Chip-Seq_TH2_Human3.38749158
8GBX2_23144817_ChIP-Seq_PC3_Human3.38460467
9SCL_19346495_ChIP-Seq_HPC-7_Human2.99080580
10* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.97178542
11TAF15_26573619_Chip-Seq_HEK293_Human2.89956451
12SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.84135498
13* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.73127426
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.62331764
15* MAF_26560356_Chip-Seq_TH1_Human2.62018601
16* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.58024771
17* MYB_26560356_Chip-Seq_TH1_Human2.54416594
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.46583707
19* UTX_26944678_Chip-Seq_JUKART_Human2.45536559
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.44824359
21* GATA3_27048872_Chip-Seq_THYMUS_Human2.35435304
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.31890549
23* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.25616175
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.25307770
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.20028318
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.19226666
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.16955806
28OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.16217309
29ER_23166858_ChIP-Seq_MCF-7_Human2.09435802
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.08654884
31POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05661306
32* MAF_26560356_Chip-Seq_TH2_Human2.04941330
33AR_21572438_ChIP-Seq_LNCaP_Human2.04930718
34IRF8_21731497_ChIP-ChIP_J774_Mouse2.02303697
35MYC_22102868_ChIP-Seq_BL_Human2.00982778
36SPI1_23547873_ChIP-Seq_NB4_Human1.93674329
37LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.82252234
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81479099
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80078054
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.80015067
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.79705866
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.76809718
43SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74133232
44BP1_19119308_ChIP-ChIP_Hs578T_Human1.71316997
45JARID2_20064375_ChIP-Seq_MESCs_Mouse1.70639052
46RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.70583673
47GATA3_26560356_Chip-Seq_TH2_Human1.69003048
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67450191
49VDR_22108803_ChIP-Seq_LS180_Human1.67332371
50* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.64928158
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.64880757
52IRF8_27001747_Chip-Seq_BMDM_Mouse1.64031512
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.63517327
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.63105408
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.61435700
56* SPI1_23127762_ChIP-Seq_K562_Human1.60646169
57SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.59865792
58EZH2_27304074_Chip-Seq_ESCs_Mouse1.59617652
59FUS_26573619_Chip-Seq_HEK293_Human1.58303080
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.55748492
61VDR_21846776_ChIP-Seq_THP-1_Human1.54486062
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.50856934
63WT1_19549856_ChIP-ChIP_CCG9911_Human1.50526565
64* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50253239
65NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49229659
66CIITA_25753668_ChIP-Seq_RAJI_Human1.48666217
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47387765
68BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47345478
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45207572
70LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44486201
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43987428
72* SMAD3_21741376_ChIP-Seq_EPCs_Human1.43883374
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43556120
74TCF7_22412390_ChIP-Seq_EML_Mouse1.41395020
75* GATA1_19941827_ChIP-Seq_MEL_Mouse1.40234221
76* CMYC_18555785_Chip-Seq_ESCs_Mouse1.39924052
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39797757
78* NANOG_18555785_Chip-Seq_ESCs_Mouse1.39560170
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.39382657
80* VDR_24763502_ChIP-Seq_THP-1_Human1.37692649
81SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36766771
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.36434962
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35992221
84STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.35907733
85* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.35228351
86* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34854956
87SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.34838225
88RNF2_18974828_ChIP-Seq_MESCs_Mouse1.33915184
89EZH2_18974828_ChIP-Seq_MESCs_Mouse1.33915184
90EZH2_27294783_Chip-Seq_NPCs_Mouse1.33819427
91SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32504820
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32429084
93* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.31387040
94* EZH2_27294783_Chip-Seq_ESCs_Mouse1.30874135
95P300_19829295_ChIP-Seq_ESCs_Human1.30415211
96* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29855253
97GATA1_19941826_ChIP-Seq_K562_Human1.29409461
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.28972412
99* P300_18555785_Chip-Seq_ESCs_Mouse1.28374348
100GATA1_22025678_ChIP-Seq_K562_Human1.28129370
101EED_16625203_ChIP-ChIP_MESCs_Mouse1.27951856
102ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27843986
103GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27744637
104* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26352340
105TAL1_26923725_Chip-Seq_HPCs_Mouse1.26286911
106* RUNX_20019798_ChIP-Seq_JUKART_Human1.25765937
107* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25163808
108* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23728506
109RNF2_27304074_Chip-Seq_ESCs_Mouse1.23516140
110* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23031019
111* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.22743450
112* PRDM14_20953172_ChIP-Seq_ESCs_Human1.20345421
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20155895
114RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20010154
115CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.19668152
116* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18292800
117* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.18209384
118* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17909822
119* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.17748726
120GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17180177
121STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16782809
122FOXP3_21729870_ChIP-Seq_TREG_Human1.16512818
123VDR_23849224_ChIP-Seq_CD4+_Human1.16486790
124SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.15750772
125* P53_22387025_ChIP-Seq_ESCs_Mouse1.15525478
126SPI1_20517297_ChIP-Seq_HL60_Human1.15273615
127KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14146512
128PIAS1_25552417_ChIP-Seq_VCAP_Human1.14115396
129HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13991341
130SMAD_19615063_ChIP-ChIP_OVARY_Human1.13638630
131* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13219580
132* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13045886
133* E2F1_18555785_Chip-Seq_ESCs_Mouse1.11316657
134* KDM2B_26808549_Chip-Seq_DND41_Human1.11106464
135* STAT3_18555785_Chip-Seq_ESCs_Mouse1.10206305
136RNF2_27304074_Chip-Seq_NSC_Mouse1.10047450
137* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.09488195
138* STAT3_23295773_ChIP-Seq_U87_Human1.09485758
139NFE2_27457419_Chip-Seq_LIVER_Mouse1.09294952
140* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08775851
141NOTCH1_21737748_ChIP-Seq_TLL_Human1.08729698
142RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08231098
143PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07419552
144* KLF4_18555785_Chip-Seq_ESCs_Mouse1.06173934
145UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05766360
146* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.04636190
147SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04604621
148POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03615127
149TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03615127
150* SOX2_18555785_Chip-Seq_ESCs_Mouse1.03544844
151CRX_20693478_ChIP-Seq_RETINA_Mouse1.02832818
152MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02646140
153* GATA2_19941826_ChIP-Seq_K562_Human1.02621569
154* TCF4_23295773_ChIP-Seq_U87_Human1.02133115
155PU_27001747_Chip-Seq_BMDM_Mouse1.01659472
156* TBL1_22424771_ChIP-Seq_293T_Human1.01408698
157EWS_26573619_Chip-Seq_HEK293_Human1.01122875
158HTT_18923047_ChIP-ChIP_STHdh_Human1.00629581
159AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00182600
160* NMYC_18555785_Chip-Seq_ESCs_Mouse0.99740442
161CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99023233
162* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98467628
163IRF1_19129219_ChIP-ChIP_H3396_Human0.98434360
164* OCT4_18555785_Chip-Seq_ESCs_Mouse0.97872099
165GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97504904
166PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94053140
167* GATA3_26560356_Chip-Seq_TH1_Human0.93878198
168CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89896555
169RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89226722
170* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87029348
171* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86761101
172NCOR1_26117541_ChIP-Seq_K562_Human0.84827929
173CTCF_21964334_ChIP-Seq_BJAB-B_Human0.83123666
174SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82694326
175PU.1_20513432_ChIP-Seq_Bcells_Mouse0.82557708
176PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82137556
177TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81016988
178* VDR_24787735_ChIP-Seq_THP-1_Human0.80993035
179PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78780400
180NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.77240393
181CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77010152
182* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.76624165
183ETS1_22383799_ChIP-Seq_G1ME_Mouse0.75240759
184CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.75018061
185STAT1_20625510_ChIP-Seq_HELA_Human0.74941987
186CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73321239
187* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.73200998
188BCL6_27268052_Chip-Seq_Bcells_Human0.73131235

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination6.09687342
2MP0003646_muscle_fatigue4.89128191
3MP0003136_yellow_coat_color3.58270345
4MP0003880_abnormal_central_pattern3.48374245
5MP0003690_abnormal_glial_cell3.17357013
6MP0003950_abnormal_plasma_membrane3.11263115
7MP0001529_abnormal_vocalization3.03948595
8MP0004742_abnormal_vestibular_system2.94007585
9MP0001835_abnormal_antigen_presentation2.86232874
10MP0005171_absent_coat_pigmentation2.84519506
11MP0000749_muscle_degeneration2.76187238
12MP0004381_abnormal_hair_follicle2.67450879
13MP0004036_abnormal_muscle_relaxation2.64266986
14MP0004885_abnormal_endolymph2.61615505
15MP0001905_abnormal_dopamine_level2.61047527
16* MP0005464_abnormal_platelet_physiology2.54182300
17MP0004270_analgesia2.52465651
18MP0001800_abnormal_humoral_immune2.44346992
19MP0005410_abnormal_fertilization2.43049031
20MP0003436_decreased_susceptibility_to2.35098928
21MP0003724_increased_susceptibility_to2.33852360
22MP0002396_abnormal_hematopoietic_system2.32972527
23MP0003634_abnormal_glial_cell2.32290532
24MP0005451_abnormal_body_composition2.30709377
25MP0002272_abnormal_nervous_system2.29852591
26MP0004142_abnormal_muscle_tone2.28520241
27MP0005409_darkened_coat_color2.26480411
28MP0001485_abnormal_pinna_reflex2.25239183
29* MP0002398_abnormal_bone_marrow2.25090890
30MP0000703_abnormal_thymus_morphology2.22559157
31MP0000751_myopathy2.20467512
32* MP0002420_abnormal_adaptive_immunity2.18421384
33MP0001486_abnormal_startle_reflex2.16544312
34MP0000778_abnormal_nervous_system2.14875716
35* MP0001819_abnormal_immune_cell2.13920188
36MP0002106_abnormal_muscle_physiology2.12720020
37* MP0002723_abnormal_immune_serum2.12236143
38* MP0004130_abnormal_muscle_cell1.96977626
39MP0000383_abnormal_hair_follicle1.96515334
40MP0005423_abnormal_somatic_nervous1.94824966
41* MP0009333_abnormal_splenocyte_physiolog1.91934066
42* MP0000716_abnormal_immune_system1.87690477
43* MP0000689_abnormal_spleen_morphology1.87506698
44MP0003329_amyloid_beta_deposits1.87470827
45* MP0002722_abnormal_immune_system1.85841911
46* MP0005025_abnormal_response_to1.84881861
47MP0002452_abnormal_antigen_presenting1.83445335
48MP0000462_abnormal_digestive_system1.78573500
49MP0002064_seizures1.77947906
50MP0002332_abnormal_exercise_endurance1.76635690
51MP0009785_altered_susceptibility_to1.75857200
52MP0006082_CNS_inflammation1.73713632
53MP0000759_abnormal_skeletal_muscle1.73056134
54MP0004087_abnormal_muscle_fiber1.72170752
55MP0002229_neurodegeneration1.68407965
56MP0002148_abnormal_hypersensitivity_rea1.68126503
57MP0000465_gastrointestinal_hemorrhage1.64996009
58MP0001873_stomach_inflammation1.64505656
59MP0006036_abnormal_mitochondrial_physio1.64466452
60MP0003632_abnormal_nervous_system1.64115318
61MP0005369_muscle_phenotype1.62983899
62MP0002419_abnormal_innate_immunity1.61973536
63MP0010678_abnormal_skin_adnexa1.61790564
64MP0000566_synostosis1.61667427
65MP0003866_abnormal_defecation1.59992293
66MP0001851_eye_inflammation1.58692444
67MP0000685_abnormal_immune_system1.58069874
68* MP0002429_abnormal_blood_cell1.57653924
69MP0002405_respiratory_system_inflammati1.55866477
70MP0003656_abnormal_erythrocyte_physiolo1.54725729
71MP0003938_abnormal_ear_development1.53859638
72MP0003303_peritoneal_inflammation1.52636903
73MP0004084_abnormal_cardiac_muscle1.51370884
74MP0008057_abnormal_DNA_replication1.50604559
75MP0004145_abnormal_muscle_electrophysio1.45962325
76MP0010155_abnormal_intestine_physiology1.44613098
77MP0002166_altered_tumor_susceptibility1.43481094
78MP0005551_abnormal_eye_electrophysiolog1.43026713
79MP0002269_muscular_atrophy1.42628740
80MP0003763_abnormal_thymus_physiology1.36963549
81MP0002734_abnormal_mechanical_nocicepti1.36556870
82MP0005620_abnormal_muscle_contractility1.35813615
83MP0005330_cardiomyopathy1.33803912
84MP0005408_hypopigmentation1.31095014
85MP0001963_abnormal_hearing_physiology1.30242938
86MP0001299_abnormal_eye_distance/1.29322392
87MP0000955_abnormal_spinal_cord1.26863042
88* MP0002752_abnormal_somatic_nervous1.25210875
89MP0009046_muscle_twitch1.24223215
90* MP0002882_abnormal_neuron_morphology1.24079501
91MP0009745_abnormal_behavioral_response1.22778830
92MP0003300_gastrointestinal_ulcer1.17339238
93MP0004484_altered_response_of1.16515086
94MP0001440_abnormal_grooming_behavior1.15558355
95MP0004808_abnormal_hematopoietic_stem1.15270362
96MP0008569_lethality_at_weaning1.15252549
97MP0002132_abnormal_respiratory_system1.14897899
98MP0001845_abnormal_inflammatory_respons1.14281744
99MP0002006_tumorigenesis1.12784907
100MP0004147_increased_porphyrin_level1.12297103
101MP0002009_preneoplasia1.11309142
102MP0004947_skin_inflammation1.10934356
103MP0003937_abnormal_limbs/digits/tail_de1.10584220
104MP0005266_abnormal_metabolism1.08124394
105MP0002066_abnormal_motor_capabilities/c1.08038843
106MP0005195_abnormal_posterior_eye1.07779593
107MP0002067_abnormal_sensory_capabilities1.06366652
108MP0000647_abnormal_sebaceous_gland1.04616424
109MP0000750_abnormal_muscle_regeneration1.04549921
110MP0004233_abnormal_muscle_weight1.04458170
111MP0005671_abnormal_response_to1.02152175
112MP0000747_muscle_weakness0.98739528
113MP0003221_abnormal_cardiomyocyte_apopto0.97968409
114MP0001970_abnormal_pain_threshold0.97659391
115MP0001545_abnormal_hematopoietic_system0.96859609
116MP0005397_hematopoietic_system_phenotyp0.96859609
117MP0002572_abnormal_emotion/affect_behav0.95177316
118MP0003828_pulmonary_edema0.94481935
119MP0004924_abnormal_behavior0.92574258
120MP0005386_behavior/neurological_phenoty0.92574258
121MP0003631_nervous_system_phenotype0.92223247
122* MP0003635_abnormal_synaptic_transmissio0.92133157
123MP0002127_abnormal_cardiovascular_syste0.92025594
124MP0005385_cardiovascular_system_phenoty0.91047066
125MP0001544_abnormal_cardiovascular_syste0.91047066
126MP0002972_abnormal_cardiac_muscle0.90815655
127MP0001533_abnormal_skeleton_physiology0.90741657
128MP0008469_abnormal_protein_level0.89430957
129MP0008260_abnormal_autophagy0.88952885
130MP0004510_myositis0.88208416
131MP0010630_abnormal_cardiac_muscle0.88134884
132MP0005623_abnormal_meninges_morphology0.88118441
133MP0000467_abnormal_esophagus_morphology0.86932342
134MP0002938_white_spotting0.86897871
135MP0000604_amyloidosis0.86653174
136MP0002736_abnormal_nociception_after0.86402203
137* MP0002019_abnormal_tumor_incidence0.86350148
138MP0003806_abnormal_nucleotide_metabolis0.86263583
139MP0005253_abnormal_eye_physiology0.85438506
140MP0002933_joint_inflammation0.85412478
141MP0000372_irregular_coat_pigmentation0.85402804
142MP0006035_abnormal_mitochondrial_morpho0.84569829
143MP0000026_abnormal_inner_ear0.83147448
144MP0002277_abnormal_respiratory_mucosa0.80285660
145MP0001968_abnormal_touch/_nociception0.80151803
146MP0001346_abnormal_lacrimal_gland0.79969008
147MP0004043_abnormal_pH_regulation0.79532922
148MP0005310_abnormal_salivary_gland0.79060818
149MP0000762_abnormal_tongue_morphology0.78955121
150MP0009250_abnormal_appendicular_skeleto0.78042580
151MP0004859_abnormal_synaptic_plasticity0.75553889
152MP0005083_abnormal_biliary_tract0.75493725
153MP0009278_abnormal_bone_marrow0.75135108
154MP0001727_abnormal_embryo_implantation0.74895891
155MP0003698_abnormal_male_reproductive0.74068913
156MP0002837_dystrophic_cardiac_calcinosis0.72218105
157MP0006072_abnormal_retinal_apoptosis0.70771645
158MP0002184_abnormal_innervation0.68778256
159MP0002152_abnormal_brain_morphology0.68614788
160MP0005387_immune_system_phenotype0.68329144
161MP0001790_abnormal_immune_system0.68329144
162MP0002733_abnormal_thermal_nociception0.67987197
163MP0000733_abnormal_muscle_development0.67680381
164MP0001340_abnormal_eyelid_morphology0.67373946
165MP0002735_abnormal_chemical_nociception0.66650837
166MP0001348_abnormal_lacrimal_gland0.66432705
167MP0001986_abnormal_taste_sensitivity0.65604606
168MP0002102_abnormal_ear_morphology0.65342221
169MP0005535_abnormal_body_temperature0.63255314
170MP0009763_increased_sensitivity_to0.63209328
171MP0003045_fibrosis0.61546156
172MP0005075_abnormal_melanosome_morpholog0.61258130
173* MP0005000_abnormal_immune_tolerance0.60811335
174* MP0004134_abnormal_chest_morphology0.60409244
175MP0009765_abnormal_xenobiotic_induced0.59657686
176MP0001853_heart_inflammation0.59569341
177MP0002063_abnormal_learning/memory/cond0.59215526
178MP0002133_abnormal_respiratory_system0.58355429
179MP0005388_respiratory_system_phenotype0.58355429
180MP0001663_abnormal_digestive_system0.57566049
181MP0009764_decreased_sensitivity_to0.57036999

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)8.59907160
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)8.21164208
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.79961495
4Degeneration of the lateral corticospinal tracts (HP:0002314)6.79961495
5Exercise-induced myalgia (HP:0003738)6.44586000
6Sensory axonal neuropathy (HP:0003390)5.77789391
7Type 1 muscle fiber predominance (HP:0003803)5.37885497
8Exercise-induced muscle cramps (HP:0003710)5.29654462
9Parakeratosis (HP:0001036)5.17553789
10Abnormality of the corticospinal tract (HP:0002492)5.07830321
11Neurofibrillary tangles (HP:0002185)5.06851615
12Peripheral hypomyelination (HP:0007182)4.85504500
13Muscle hypertrophy of the lower extremities (HP:0008968)4.35244210
14Distal arthrogryposis (HP:0005684)4.27293857
15Myopathic facies (HP:0002058)4.20205421
16Rhabdomyolysis (HP:0003201)4.16826123
17Centrally nucleated skeletal muscle fibers (HP:0003687)3.82043790
18Subaortic stenosis (HP:0001682)3.81286191
19Abnormality of the left ventricular outflow tract (HP:0011103)3.81286191
20Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.80507479
21Hypoplastic pelvis (HP:0008839)3.78772807
22EMG: myopathic abnormalities (HP:0003458)3.78146981
23Calf muscle hypertrophy (HP:0008981)3.72871910
24Myoglobinuria (HP:0002913)3.63315774
25Abnormal auditory evoked potentials (HP:0006958)3.62229092
26Cerebral hypomyelination (HP:0006808)3.50775146
27Elevated erythrocyte sedimentation rate (HP:0003565)3.45536723
28Neck muscle weakness (HP:0000467)3.39252118
29Abnormality of skeletal muscle fiber size (HP:0012084)3.38642806
30Spastic gait (HP:0002064)3.35859018
31Premature skin wrinkling (HP:0100678)3.35282594
32Autoimmune hemolytic anemia (HP:0001890)3.35101275
33Onion bulb formation (HP:0003383)3.30875772
34Rimmed vacuoles (HP:0003805)3.29078356
35Muscle stiffness (HP:0003552)3.26007309
36Abnormality of T cells (HP:0002843)3.24487912
37Prolonged bleeding time (HP:0003010)3.19905115
38Cerebral inclusion bodies (HP:0100314)3.19637648
39Akinesia (HP:0002304)3.19176423
40Abnormality of glycolysis (HP:0004366)3.18190733
41Increased serum pyruvate (HP:0003542)3.18190733
42Abnormal delayed hypersensitivity skin test (HP:0002963)3.12919465
43Ulnar deviation of the wrist (HP:0003049)3.12834145
44Panhypogammaglobulinemia (HP:0003139)3.09598170
45Round ear (HP:0100830)3.06300766
46Myositis (HP:0100614)3.05678824
47Difficulty running (HP:0009046)3.02553063
48Retinal dysplasia (HP:0007973)2.99027254
49Small epiphyses (HP:0010585)2.92708049
50Alacrima (HP:0000522)2.90017040
51Absent septum pellucidum (HP:0001331)2.88275787
52Eczematoid dermatitis (HP:0000976)2.84366683
53Adrenal hypoplasia (HP:0000835)2.82548412
54Supranuclear gaze palsy (HP:0000605)2.79719999
55Anteriorly placed anus (HP:0001545)2.76855986
56Severe combined immunodeficiency (HP:0004430)2.76776997
57Areflexia of lower limbs (HP:0002522)2.76333438
58Partial agenesis of the corpus callosum (HP:0001338)2.73228100
59Encephalitis (HP:0002383)2.72497807
60White forelock (HP:0002211)2.71512444
61Slow saccadic eye movements (HP:0000514)2.70212562
62Dysmetria (HP:0001310)2.69347150
63Intention tremor (HP:0002080)2.68468254
64Decreased lacrimation (HP:0000633)2.65580174
65Recurrent fungal infections (HP:0002841)2.64437069
66Anomalous pulmonary venous return (HP:0010772)2.63347888
67Abnormality of the septum pellucidum (HP:0007375)2.62665214
68Patchy hypopigmentation of hair (HP:0011365)2.62613139
69Congenital ichthyosiform erythroderma (HP:0007431)2.60424623
70Chin dimple (HP:0010751)2.59157116
71Hypomagnesemia (HP:0002917)2.59118733
72Chest pain (HP:0100749)2.55922182
73Spastic paraparesis (HP:0002313)2.53912938
74Increased variability in muscle fiber diameter (HP:0003557)2.53089047
75Optic neuritis (HP:0100653)2.52348584
76Retrobulbar optic neuritis (HP:0100654)2.52348584
77Granulocytopenia (HP:0001913)2.51653648
78Morphological abnormality of the inner ear (HP:0011390)2.47226987
79Cupped ear (HP:0000378)2.46821647
80Frequent falls (HP:0002359)2.45690573
81Barrel-shaped chest (HP:0001552)2.44351948
82Eosinophilia (HP:0001880)2.43587192
83Malignant hyperthermia (HP:0002047)2.43291622
84Renal Fanconi syndrome (HP:0001994)2.42319961
85Stridor (HP:0010307)2.40993934
86Absent phalangeal crease (HP:0006109)2.40011298
87Leukodystrophy (HP:0002415)2.38340989
88Abnormality of the calf musculature (HP:0001430)2.38319204
89T lymphocytopenia (HP:0005403)2.37752621
90Orchitis (HP:0100796)2.37264105
91Generalized muscle weakness (HP:0003324)2.37109476
92Recurrent viral infections (HP:0004429)2.36394141
93EMG: neuropathic changes (HP:0003445)2.35881565
94Epistaxis (HP:0000421)2.32852116
95Calcaneovalgus deformity (HP:0001848)2.32625057
96Scanning speech (HP:0002168)2.32541265
97Termporal pattern (HP:0011008)2.32262549
98Insidious onset (HP:0003587)2.32262549
99Leukocytosis (HP:0001974)2.32031950
100Abnormality of T cell physiology (HP:0011840)2.30409940
101Meningitis (HP:0001287)2.30176352
102Humeroradial synostosis (HP:0003041)2.28622501
103Synostosis involving the elbow (HP:0003938)2.28622501
104Recurrent bacterial skin infections (HP:0005406)2.28318033
105Asymmetric septal hypertrophy (HP:0001670)2.27380866
106IgG deficiency (HP:0004315)2.27168896
107Cerebral hemorrhage (HP:0001342)2.26661558
108Segmental peripheral demyelination/remyelination (HP:0003481)2.25754736
109IgM deficiency (HP:0002850)2.24866674
110Hypoplasia of the iris (HP:0007676)2.24146199
111Gastrointestinal infarctions (HP:0005244)2.23251433
112Autoamputation (HP:0001218)2.22326440
113Abnormality of the pulmonary veins (HP:0011718)2.22104601
114Increased intramyocellular lipid droplets (HP:0012240)2.21394516
115Stomatitis (HP:0010280)2.21203507
116Hepatosplenomegaly (HP:0001433)2.20805653
117Spontaneous hematomas (HP:0007420)2.20218770
118Split foot (HP:0001839)2.18923792
119Abnormality of T cell number (HP:0011839)2.18487844
120Recurrent abscess formation (HP:0002722)2.18193241
121Thickened helices (HP:0000391)2.17963551
122Pustule (HP:0200039)2.16433585
123Atonic seizures (HP:0010819)2.15203056
124Combined immunodeficiency (HP:0005387)2.13951224
125Myotonia (HP:0002486)2.13561086
1263-Methylglutaconic aciduria (HP:0003535)2.12159121
127Sudden death (HP:0001699)2.11412546
128Increased IgM level (HP:0003496)2.11408061
129Increased circulating renin level (HP:0000848)2.10364560
130Petechiae (HP:0000967)2.08947253
131Progressive muscle weakness (HP:0003323)2.07462648
132Increased muscle lipid content (HP:0009058)2.05542912
133Abnormal finger flexion creases (HP:0006143)2.05458613
134Chronic mucocutaneous candidiasis (HP:0002728)2.05430904
135Recurrent cutaneous fungal infections (HP:0011370)2.05430904
136CNS hypomyelination (HP:0003429)2.03691163
137Inflammation of the large intestine (HP:0002037)2.02777235
138Weak cry (HP:0001612)2.02429275
139Obstructive lung disease (HP:0006536)2.01607339
140Chronic obstructive pulmonary disease (HP:0006510)2.01607339
141Deformed tarsal bones (HP:0008119)2.01586695
142Hyperkalemia (HP:0002153)2.01405756
143Bulbar palsy (HP:0001283)1.99925681
144Increased connective tissue (HP:0009025)1.98687574
145Gastrointestinal inflammation (HP:0004386)1.98272015
146Facial diplegia (HP:0001349)1.97648523
147Gastrointestinal stroma tumor (HP:0100723)1.96203823
148Distal lower limb muscle weakness (HP:0009053)1.95169899
149Fatigue (HP:0012378)1.94498608
150Septo-optic dysplasia (HP:0100842)1.93549599
151Keratoconjunctivitis sicca (HP:0001097)1.92385919
152Muscle fiber splitting (HP:0003555)1.92362622
153Nemaline bodies (HP:0003798)1.91333093
154Gingival bleeding (HP:0000225)1.90617317
155Abnormal large intestine physiology (HP:0012700)1.87097750
156Dynein arm defect of respiratory motile cilia (HP:0012255)1.84729627
157Absent/shortened dynein arms (HP:0200106)1.84729627
158Esophageal atresia (HP:0002032)1.83847435
159Abnormality of B cell number (HP:0010975)1.82995474
160Paralysis (HP:0003470)1.82739674
161Type II lissencephaly (HP:0007260)1.81967505
162Bowel incontinence (HP:0002607)1.81870531
163Keratoconjunctivitis (HP:0001096)1.80746174
164Vasculitis (HP:0002633)1.79951586
165Abnormality of macrophages (HP:0004311)1.79205669
166Abolished electroretinogram (ERG) (HP:0000550)1.79109053
167Hyporeflexia of lower limbs (HP:0002600)1.78379531
168Arterial thrombosis (HP:0004420)1.77981447
169Epiphyseal dysplasia (HP:0002656)1.77786867
170Abnormal platelet volume (HP:0011876)1.77636473
171Metabolic alkalosis (HP:0200114)1.76841358
172Meningocele (HP:0002435)1.76740925
173Abnormality of the phalanges of the 2nd finger (HP:0009541)1.76315345
174Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.75747563
175Asplenia (HP:0001746)1.75563444
176Erythroderma (HP:0001019)1.74482623
177Generalized myoclonic seizures (HP:0002123)1.74080220
178Gowers sign (HP:0003391)1.73576806
179Duplicated collecting system (HP:0000081)1.73473351
180Seborrheic dermatitis (HP:0001051)1.72803030
181Relative macrocephaly (HP:0004482)1.72233804
182Increased hepatocellular lipid droplets (HP:0006565)1.71686420
183Conical tooth (HP:0000698)1.70089554
184Hypokalemic alkalosis (HP:0001949)1.67966700
185Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.67766236
186Myelomeningocele (HP:0002475)1.66806337
187Steppage gait (HP:0003376)1.66752768
188Widely spaced teeth (HP:0000687)1.65306729
189Stomach cancer (HP:0012126)1.64861598
190Lower limb muscle weakness (HP:0007340)1.63787268
191Abnormality of eosinophils (HP:0001879)1.62222429
192Clumsiness (HP:0002312)1.59774893
193Irregular epiphyses (HP:0010582)1.59506331

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.18634290
2OXSR14.13159142
3EPHB13.95160304
4TNIK3.59024167
5TTN3.12502667
6PIK3CG2.81586665
7TYRO32.65003772
8MAP2K32.62499848
9PKN12.55520028
10TAOK32.50291347
11BCR2.33082316
12PBK2.25339611
13WNK42.24986261
14ZAP702.21026517
15RIPK42.19142858
16NEK62.17292850
17BTK2.09647395
18ICK1.94850622
19TEC1.94730416
20CDK191.94534611
21SYK1.89395909
22MST41.86622920
23KDR1.79259820
24CSNK1G31.78224960
25MET1.74810244
26GRK61.70407399
27WNK11.70210458
28CSNK1A1L1.68491422
29MAPKAPK51.66214199
30TNK21.65413856
31FES1.64659687
32FGFR21.63914727
33CLK11.59988939
34CSNK1G11.58218781
35FGR1.56329330
36PNCK1.53842824
37MAPK121.53341167
38LIMK11.49971696
39TXK1.45290372
40BCKDK1.45144426
41UHMK11.35369252
42TYK21.33933792
43TESK21.32109509
44PRPF4B1.31006148
45ROCK21.29659545
46HCK1.28674472
47CSNK1G21.28549636
48MUSK1.24173128
49PAK61.22080501
50PDGFRB1.20767702
51ITK1.20356594
52CSK1.18549300
53MAP3K71.18128420
54IRAK21.17329976
55CASK1.13963139
56MAP3K111.10010186
57MAP2K61.04618983
58CAMK2B1.03830486
59DYRK20.99189350
60JAK10.95960613
61NLK0.91825380
62MARK20.89940629
63PINK10.89437577
64TBK10.88406679
65IRAK10.88286044
66PASK0.88008433
67CAMKK20.87514834
68SCYL20.86342870
69PIM10.86221626
70CAMK2D0.85509110
71MAPK110.79105060
72BLK0.77800679
73NTRK10.77416397
74JAK20.73161422
75* PRKCQ0.71068558
76IRAK40.71054660
77SGK2230.70426800
78SGK4940.70426800
79PAK30.69233595
80MAP4K10.68889263
81FGFR30.67726442
82MAP3K140.67205401
83MAP3K10.66642020
84TRPM70.66629065
85* LCK0.66576839
86MAPK130.64634009
87ERBB40.63846702
88IKBKB0.62623644
89FYN0.61104789
90CAMK2G0.60593335
91ADRBK20.60354031
92PDK10.59728088
93BMPR1B0.59228658
94OBSCN0.59175378
95RPS6KA50.58530623
96PHKG10.57160413
97PHKG20.57160413
98MAPK70.56422871
99CAMK2A0.56221481
100MARK30.55745798
101CSNK1D0.50172520
102KIT0.49929701
103CDK140.49344482
104MAPK150.48721684
105TAOK20.47481816
106PRKCH0.47206348
107CDK50.46670236
108SGK20.45249823
109HIPK20.45062508
110MARK10.44924074
111SIK30.44874371
112INSR0.44675610
113RAF10.44583535
114NME10.42054244
115EPHA40.41829454
116PDPK10.41567175
117NUAK10.41434511
118PRKG10.41303020
119SGK30.41293358
120CDK40.41123219
121MAP3K30.40998641
122CDK30.40931228
123CSNK1A10.40741125
124IKBKE0.40712979
125MAP2K40.39868926
126PRKD10.39809044
127MELK0.39778266
128CDK150.39690641
129CDK11A0.39541896
130DYRK1B0.38876216
131MAP3K130.38285022
132STK100.36361482
133MAPKAPK30.35724332
134CAMK1G0.35342712
135GSK3A0.35224402
136BRD40.34803921
137CDK180.34467834
138STK160.34171618
139RPS6KA40.34115347
140LYN0.33170874
141CSF1R0.33028439
142CAMK40.32848272
143VRK20.32260385
144DYRK1A0.32232007
145PRKCE0.32026527
146MKNK10.30128965
147CAMKK10.29712934
148MAP3K100.29669064
149PRKD20.29187832
150PTK2B0.28055514
151PIK3CA0.27463325
152MAPK40.27438478
153JAK30.27111263
154RPS6KC10.26926148
155RPS6KL10.26926148
156MAP3K50.26511907
157RPS6KB20.25505938
158GRK70.25432585
159RPS6KA60.25185312
160MAPK30.24938925
161PRKAA20.24359181
162STK110.23854905
163RPS6KB10.21521450
164CAMK10.20942935
165SGK10.18032955
166CDK120.17990194
167RPS6KA10.17435648
168LRRK20.17059272

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.68743145
2Steroid biosynthesis_Homo sapiens_hsa001005.26836025
3Fatty acid elongation_Homo sapiens_hsa000624.08976705
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.66682580
5Ether lipid metabolism_Homo sapiens_hsa005653.62018565
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.06153542
7Sphingolipid metabolism_Homo sapiens_hsa006002.25841891
8Vitamin B6 metabolism_Homo sapiens_hsa007502.19434920
9* Measles_Homo sapiens_hsa051622.12479579
10Antigen processing and presentation_Homo sapiens_hsa046122.01493902
11Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.98573679
12Axon guidance_Homo sapiens_hsa043601.87490547
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.85333202
14Protein export_Homo sapiens_hsa030601.83892203
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.81979872
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.75442637
17Linoleic acid metabolism_Homo sapiens_hsa005911.72386125
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.71910777
19Osteoclast differentiation_Homo sapiens_hsa043801.71594518
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.69761527
21Oxidative phosphorylation_Homo sapiens_hsa001901.68304214
22Acute myeloid leukemia_Homo sapiens_hsa052211.65425586
23* NF-kappa B signaling pathway_Homo sapiens_hsa040641.62578084
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.60939239
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.57242116
26Type I diabetes mellitus_Homo sapiens_hsa049401.55484798
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.51139995
28Primary immunodeficiency_Homo sapiens_hsa053401.47629744
29Autoimmune thyroid disease_Homo sapiens_hsa053201.46245346
30Leishmaniasis_Homo sapiens_hsa051401.44126449
31Renal cell carcinoma_Homo sapiens_hsa052111.35491956
32Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.33744532
33Non-small cell lung cancer_Homo sapiens_hsa052231.33056595
34* T cell receptor signaling pathway_Homo sapiens_hsa046601.31620223
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.24230807
36Herpes simplex infection_Homo sapiens_hsa051681.23802345
37Circadian rhythm_Homo sapiens_hsa047101.23768475
38Histidine metabolism_Homo sapiens_hsa003401.21961269
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.16532770
40Sphingolipid signaling pathway_Homo sapiens_hsa040711.12093649
41Basal transcription factors_Homo sapiens_hsa030221.10948455
42Dilated cardiomyopathy_Homo sapiens_hsa054141.07101687
43Calcium signaling pathway_Homo sapiens_hsa040201.03757846
44Oxytocin signaling pathway_Homo sapiens_hsa049211.03359015
45Sulfur metabolism_Homo sapiens_hsa009201.03267985
46Glutamatergic synapse_Homo sapiens_hsa047241.03164859
47Alzheimers disease_Homo sapiens_hsa050101.02207443
48Serotonergic synapse_Homo sapiens_hsa047261.01869881
49Butanoate metabolism_Homo sapiens_hsa006500.99681595
50Insulin signaling pathway_Homo sapiens_hsa049100.98869380
51Parkinsons disease_Homo sapiens_hsa050120.96423281
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.96384556
53Graft-versus-host disease_Homo sapiens_hsa053320.96316866
54Rheumatoid arthritis_Homo sapiens_hsa053230.95810758
55VEGF signaling pathway_Homo sapiens_hsa043700.93025342
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90723112
57Glucagon signaling pathway_Homo sapiens_hsa049220.90183732
58Choline metabolism in cancer_Homo sapiens_hsa052310.89077775
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89036790
60FoxO signaling pathway_Homo sapiens_hsa040680.88658291
61Viral carcinogenesis_Homo sapiens_hsa052030.87623608
62Arachidonic acid metabolism_Homo sapiens_hsa005900.87018019
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86513980
64* Insulin resistance_Homo sapiens_hsa049310.85880521
65Malaria_Homo sapiens_hsa051440.84431622
66Long-term depression_Homo sapiens_hsa047300.83764114
67Long-term potentiation_Homo sapiens_hsa047200.82778625
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80937110
69RNA polymerase_Homo sapiens_hsa030200.80927011
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80689518
71Pancreatic cancer_Homo sapiens_hsa052120.80618411
72Epstein-Barr virus infection_Homo sapiens_hsa051690.78985946
73Tuberculosis_Homo sapiens_hsa051520.78637691
74Allograft rejection_Homo sapiens_hsa053300.78004252
75TNF signaling pathway_Homo sapiens_hsa046680.77663405
76HTLV-I infection_Homo sapiens_hsa051660.77431351
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76300351
78Legionellosis_Homo sapiens_hsa051340.76270196
79Arginine and proline metabolism_Homo sapiens_hsa003300.75525880
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75180435
81Ras signaling pathway_Homo sapiens_hsa040140.74230183
82* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73464701
83Nitrogen metabolism_Homo sapiens_hsa009100.72781377
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71666424
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.71268785
86Shigellosis_Homo sapiens_hsa051310.71244554
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70106575
88Hepatitis B_Homo sapiens_hsa051610.68818998
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68014796
90Influenza A_Homo sapiens_hsa051640.66955164
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66763997
92Inositol phosphate metabolism_Homo sapiens_hsa005620.65520197
93Renin secretion_Homo sapiens_hsa049240.64646123
94Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64286983
95Non-homologous end-joining_Homo sapiens_hsa034500.63366885
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63319446
97Chronic myeloid leukemia_Homo sapiens_hsa052200.62461306
98Endocytosis_Homo sapiens_hsa041440.60835474
99Ovarian steroidogenesis_Homo sapiens_hsa049130.60748310
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56886632
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56304778
102Olfactory transduction_Homo sapiens_hsa047400.56035926
103Ribosome_Homo sapiens_hsa030100.55626054
104Prolactin signaling pathway_Homo sapiens_hsa049170.55525035
105Huntingtons disease_Homo sapiens_hsa050160.54501248
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54396530
107Phototransduction_Homo sapiens_hsa047440.53311941
108Pentose phosphate pathway_Homo sapiens_hsa000300.53159076
109Apoptosis_Homo sapiens_hsa042100.52522222
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51692142
111ErbB signaling pathway_Homo sapiens_hsa040120.51375537
112Chemokine signaling pathway_Homo sapiens_hsa040620.51341924
113Collecting duct acid secretion_Homo sapiens_hsa049660.51313137
114Purine metabolism_Homo sapiens_hsa002300.50433918
115* Tight junction_Homo sapiens_hsa045300.50410310
116Cardiac muscle contraction_Homo sapiens_hsa042600.50312181
117Hematopoietic cell lineage_Homo sapiens_hsa046400.49842632
118Thyroid cancer_Homo sapiens_hsa052160.48818651
119Asthma_Homo sapiens_hsa053100.48355829
120Toxoplasmosis_Homo sapiens_hsa051450.47755762
121Cholinergic synapse_Homo sapiens_hsa047250.47330145
122* Adipocytokine signaling pathway_Homo sapiens_hsa049200.47103123
123Intestinal immune network for IgA production_Homo sapiens_hsa046720.46888625
124Regulation of autophagy_Homo sapiens_hsa041400.46641063
125Dorso-ventral axis formation_Homo sapiens_hsa043200.45731290
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44544538
127GABAergic synapse_Homo sapiens_hsa047270.44542842
128B cell receptor signaling pathway_Homo sapiens_hsa046620.44213380
129Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44091806
130ECM-receptor interaction_Homo sapiens_hsa045120.43216699
131Colorectal cancer_Homo sapiens_hsa052100.42719640
132Hedgehog signaling pathway_Homo sapiens_hsa043400.42109227
133Steroid hormone biosynthesis_Homo sapiens_hsa001400.41852764
134Morphine addiction_Homo sapiens_hsa050320.41307502
135RNA degradation_Homo sapiens_hsa030180.41067642
136Fatty acid metabolism_Homo sapiens_hsa012120.40747905
137Prostate cancer_Homo sapiens_hsa052150.39426977
138Proteasome_Homo sapiens_hsa030500.38969280
139Neurotrophin signaling pathway_Homo sapiens_hsa047220.38491250
140Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38087266
141Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37290310
142Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37228539
143Glutathione metabolism_Homo sapiens_hsa004800.37036928
144Salmonella infection_Homo sapiens_hsa051320.36609893
145Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35130689
146mTOR signaling pathway_Homo sapiens_hsa041500.34699013
147Leukocyte transendothelial migration_Homo sapiens_hsa046700.34232092
148Staphylococcus aureus infection_Homo sapiens_hsa051500.34221501
149Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33181390
150* Vascular smooth muscle contraction_Homo sapiens_hsa042700.32656083
151Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.31931136
152Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31462954
153Endometrial cancer_Homo sapiens_hsa052130.30799597
154MAPK signaling pathway_Homo sapiens_hsa040100.30403648
155Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30065663
156Metabolic pathways_Homo sapiens_hsa011000.29227816
157Viral myocarditis_Homo sapiens_hsa054160.28984366
158Platelet activation_Homo sapiens_hsa046110.27698845
159Vibrio cholerae infection_Homo sapiens_hsa051100.25585550
160Prion diseases_Homo sapiens_hsa050200.25443775
161PI3K-Akt signaling pathway_Homo sapiens_hsa041510.23312476
162Lysosome_Homo sapiens_hsa041420.21607613
163Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20929855
164Hepatitis C_Homo sapiens_hsa051600.20891185
165Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.20369735
166Fatty acid biosynthesis_Homo sapiens_hsa000610.20297355
167Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20095696
168Salivary secretion_Homo sapiens_hsa049700.19850173

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