PRKCSH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the beta-subunit of glucosidase II, an N-linked glycan-processing enzyme in the endoplasmic reticulum. The encoded protein is an acidic phosphoprotein known to be a substrate for protein kinase C. Mutations in this gene have been associated with the autosomal dominant polycystic liver disease. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)4.31695416
2Golgi transport vesicle coating (GO:0048200)4.31695416
3negative regulation of fibrinolysis (GO:0051918)4.24893026
4negative regulation of erythrocyte differentiation (GO:0045647)4.21314414
54-hydroxyproline metabolic process (GO:0019471)4.02337835
6sulfur amino acid catabolic process (GO:0000098)4.00218652
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.96928453
8L-phenylalanine metabolic process (GO:0006558)3.96928453
9protein localization to endosome (GO:0036010)3.92555620
10folic acid-containing compound biosynthetic process (GO:0009396)3.90338816
11planar cell polarity pathway involved in neural tube closure (GO:0090179)3.85254130
12regulation of cholesterol homeostasis (GO:2000188)3.84798827
13glycine metabolic process (GO:0006544)3.75824135
14regulation of mammary gland epithelial cell proliferation (GO:0033599)3.74437545
15adherens junction assembly (GO:0034333)3.68996592
16lysine catabolic process (GO:0006554)3.66109731
17lysine metabolic process (GO:0006553)3.66109731
18L-phenylalanine catabolic process (GO:0006559)3.64842663
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.64842663
20retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.64661298
21alpha-linolenic acid metabolic process (GO:0036109)3.64644867
22mannose metabolic process (GO:0006013)3.64296007
23glyoxylate metabolic process (GO:0046487)3.61936588
24maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.59748688
25regulation of early endosome to late endosome transport (GO:2000641)3.56779042
26focal adhesion assembly (GO:0048041)3.56732817
27cell-substrate adherens junction assembly (GO:0007045)3.56732817
28protein carboxylation (GO:0018214)3.52624183
29peptidyl-glutamic acid carboxylation (GO:0017187)3.52624183
30regulation of translational fidelity (GO:0006450)3.49146793
31regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.47982158
32triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.44010721
33maternal placenta development (GO:0001893)3.42287535
34serine family amino acid biosynthetic process (GO:0009070)3.41011969
35activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.39863710
36cysteine metabolic process (GO:0006534)3.39208138
37pentose-phosphate shunt (GO:0006098)3.39181092
38activation of Rac GTPase activity (GO:0032863)3.38177360
39protein retention in ER lumen (GO:0006621)3.37424487
40regulation of fibrinolysis (GO:0051917)3.35087037
41positive regulation of nuclease activity (GO:0032075)3.34371139
42apoptotic process involved in morphogenesis (GO:0060561)3.32731380
43negative regulation of sterol transport (GO:0032372)3.32627758
44negative regulation of cholesterol transport (GO:0032375)3.32627758
45cell-substrate junction assembly (GO:0007044)3.26602317
46heterochromatin organization (GO:0070828)3.23051210
47barbed-end actin filament capping (GO:0051016)3.23000001
48urea cycle (GO:0000050)3.20921061
49urea metabolic process (GO:0019627)3.20921061
50cellular modified amino acid catabolic process (GO:0042219)3.20904023
51cytoskeletal anchoring at plasma membrane (GO:0007016)3.18750252
52serine family amino acid metabolic process (GO:0009069)3.17044886
53kynurenine metabolic process (GO:0070189)3.15285935
54glucose 6-phosphate metabolic process (GO:0051156)3.15005985
55NADPH regeneration (GO:0006740)3.14468482
56regulation of glucose import in response to insulin stimulus (GO:2001273)3.13678935
57tetrahydrofolate metabolic process (GO:0046653)3.13318626
58regulation of fatty acid beta-oxidation (GO:0031998)3.13017815
59serine family amino acid catabolic process (GO:0009071)3.10904929
60aromatic amino acid family catabolic process (GO:0009074)3.10216973
61semaphorin-plexin signaling pathway (GO:0071526)3.09496647
62spliceosomal tri-snRNP complex assembly (GO:0000244)3.07495575
63homocysteine metabolic process (GO:0050667)3.07480517
64high-density lipoprotein particle remodeling (GO:0034375)3.06323711
65L-serine metabolic process (GO:0006563)3.06310692
66regulation of protein activation cascade (GO:2000257)3.06070932
67proline biosynthetic process (GO:0006561)3.04837443
68regulation of nuclease activity (GO:0032069)3.04403721
69skin morphogenesis (GO:0043589)3.03947273
70endoplasmic reticulum unfolded protein response (GO:0030968)3.01829067
71complement activation, alternative pathway (GO:0006957)2.96361759
72positive regulation of triglyceride biosynthetic process (GO:0010867)2.96352203
73one-carbon metabolic process (GO:0006730)2.95158115
74positive regulation of histone deacetylation (GO:0031065)2.93669629
75regulation of complement activation (GO:0030449)2.92667929
763-UTR-mediated mRNA stabilization (GO:0070935)2.91950512
77positive regulation of blood vessel endothelial cell migration (GO:0043536)2.87802552
78apoptotic cell clearance (GO:0043277)2.87308233
79stress fiber assembly (GO:0043149)2.87110592
80nitrogen cycle metabolic process (GO:0071941)2.86950953
81regulation of extracellular matrix disassembly (GO:0010715)2.86805560
82cellular response to unfolded protein (GO:0034620)2.86448066
83reverse cholesterol transport (GO:0043691)2.85751853
84negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.85748953
85epoxygenase P450 pathway (GO:0019373)2.85467182
86regulation of NFAT protein import into nucleus (GO:0051532)2.85283870
87pinocytosis (GO:0006907)2.85030625
88embryonic process involved in female pregnancy (GO:0060136)2.84906687
89epithelial cell-cell adhesion (GO:0090136)2.83603954
90COPII vesicle coating (GO:0048208)2.83404986
91folic acid metabolic process (GO:0046655)2.82087844
92modulation by symbiont of host cellular process (GO:0044068)2.81907796
93plasma lipoprotein particle clearance (GO:0034381)2.79794198
94intracellular estrogen receptor signaling pathway (GO:0030520)2.79212899
95low-density lipoprotein particle clearance (GO:0034383)2.78862438
96negative regulation of lipid transport (GO:0032369)2.77973368
97regulation of histone H3-K27 methylation (GO:0061085)2.76794290
98regulation of plasminogen activation (GO:0010755)2.74967348
99response to laminar fluid shear stress (GO:0034616)2.74747270
100ER-nucleus signaling pathway (GO:0006984)2.74649195
101positive regulation of triglyceride metabolic process (GO:0090208)2.73671109
102negative regulation of fatty acid transport (GO:2000192)2.73649965
103bile acid biosynthetic process (GO:0006699)2.73255514
104cellular response to epidermal growth factor stimulus (GO:0071364)2.72389344
105positive regulation of fatty acid beta-oxidation (GO:0032000)2.72291836
106tricarboxylic acid metabolic process (GO:0072350)2.71998042
107mRNA stabilization (GO:0048255)2.71863949
108RNA stabilization (GO:0043489)2.71863949
109mitotic chromosome condensation (GO:0007076)2.70640610
110protein maturation by protein folding (GO:0022417)2.69851826
111modulation by virus of host process (GO:0019054)2.69265174
112basement membrane organization (GO:0071711)2.68752262
113indole-containing compound catabolic process (GO:0042436)2.68472737
114indolalkylamine catabolic process (GO:0046218)2.68472737
115tryptophan catabolic process (GO:0006569)2.68472737
116cellular response to topologically incorrect protein (GO:0035967)2.67982803
117negative regulation of cell size (GO:0045792)2.67933689
118positive regulation of Cdc42 GTPase activity (GO:0043089)2.67307908
119DNA unwinding involved in DNA replication (GO:0006268)2.67171631
120L-alpha-amino acid transmembrane transport (GO:1902475)2.66158519
121lipoprotein metabolic process (GO:0042157)2.65643799
122fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.65468862
123hemidesmosome assembly (GO:0031581)2.64608788
124valine metabolic process (GO:0006573)2.63511131
125epithelial cell differentiation involved in prostate gland development (GO:0060742)2.63087821
126peptidyl-proline hydroxylation (GO:0019511)2.63055141
1272-oxoglutarate metabolic process (GO:0006103)2.62694035
128modulation by virus of host morphology or physiology (GO:0019048)2.62553204
129protein-DNA complex disassembly (GO:0032986)2.57862776
130nucleosome disassembly (GO:0006337)2.57862776
131proline metabolic process (GO:0006560)2.56921452
132amino-acid betaine metabolic process (GO:0006577)2.56197776
133folic acid-containing compound metabolic process (GO:0006760)2.55408591
134tryptophan metabolic process (GO:0006568)2.55212978
135insulin-like growth factor receptor signaling pathway (GO:0048009)2.54370473
136positive regulation of fatty acid biosynthetic process (GO:0045723)2.53984618
137pteridine-containing compound biosynthetic process (GO:0042559)2.53983731
138regulation of nucleobase-containing compound transport (GO:0032239)2.52991337
139ethanol oxidation (GO:0006069)2.52983982
140regulation of hippo signaling (GO:0035330)2.52820909
141protein-lipid complex remodeling (GO:0034368)2.50513866
142macromolecular complex remodeling (GO:0034367)2.50513866
143plasma lipoprotein particle remodeling (GO:0034369)2.50513866
144glucocorticoid receptor signaling pathway (GO:0042921)2.50293178
145glucose catabolic process (GO:0006007)2.49689489
146branching involved in mammary gland duct morphogenesis (GO:0060444)2.48552720
147cell-cell junction maintenance (GO:0045217)2.46963140
148protein-lipid complex assembly (GO:0065005)2.46484339
149regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.46140670
150triglyceride homeostasis (GO:0070328)2.45827562
151acylglycerol homeostasis (GO:0055090)2.45827562
152alpha-amino acid catabolic process (GO:1901606)2.45603859
153negative regulation of fatty acid biosynthetic process (GO:0045717)2.45267715
154activation of MAPKKK activity (GO:0000185)2.45062117
155protein targeting to plasma membrane (GO:0072661)2.42724800
156positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.42687795
157membrane protein ectodomain proteolysis (GO:0006509)2.42152033
158UV protection (GO:0009650)2.40976467
159positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.40524759
160vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.39652898
161positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.39314603
162dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.38577309
163hyaluronan catabolic process (GO:0030214)2.38545609
164endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.38334852
165regulation of RNA export from nucleus (GO:0046831)2.37996898
166convergent extension (GO:0060026)2.36797959
167cortical actin cytoskeleton organization (GO:0030866)2.36622251
168peptidyl-arginine omega-N-methylation (GO:0035247)2.35001531
169Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.34257878
170regulation of chromatin binding (GO:0035561)2.32787007
171establishment of apical/basal cell polarity (GO:0035089)2.32765082
172negative regulation of viral release from host cell (GO:1902187)2.31483650
173atrioventricular valve morphogenesis (GO:0003181)2.31225229
174embryo implantation (GO:0007566)2.27128466
175protein hydroxylation (GO:0018126)2.26366823
176vesicle coating (GO:0006901)2.26069500
177desmosome organization (GO:0002934)2.25752378

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.51124698
2E2F7_22180533_ChIP-Seq_HELA_Human3.63575542
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.15327990
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.05794608
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.86446135
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.82938855
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.55339084
8MYC_22102868_ChIP-Seq_BL_Human2.39259437
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.30902880
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.29380248
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.23121855
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.19274942
13CLOCK_20551151_ChIP-Seq_293T_Human2.17757732
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08442729
15MYC_18555785_ChIP-Seq_MESCs_Mouse1.98633793
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90379115
17CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.87349580
18VDR_21846776_ChIP-Seq_THP-1_Human1.85076902
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84860595
20ELK3_25401928_ChIP-Seq_HUVEC_Human1.77425150
21* LXR_22292898_ChIP-Seq_THP-1_Human1.73129168
22POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.71749825
23KDM2B_26808549_Chip-Seq_K562_Human1.70157975
24STAT3_1855785_ChIP-Seq_MESCs_Mouse1.67548866
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.65551315
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.60280343
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59920277
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.53899983
29RACK7_27058665_Chip-Seq_MCF-7_Human1.52659236
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49988054
31TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49640481
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.48965056
33ZNF263_19887448_ChIP-Seq_K562_Human1.47199348
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.46748806
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45774684
36ATF3_27146783_Chip-Seq_COLON_Human1.45568627
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.44426044
38VDR_24763502_ChIP-Seq_THP-1_Human1.44348432
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.42990441
40ESR1_15608294_ChIP-ChIP_MCF-7_Human1.42910952
41CTCF_27219007_Chip-Seq_ERYTHROID_Human1.42618346
42ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.41789357
43* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.41480562
44EGR1_23403033_ChIP-Seq_LIVER_Mouse1.39872118
45FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.39711568
46KDM2B_26808549_Chip-Seq_JURKAT_Human1.39258517
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37792020
48KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.36855626
49NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.35802915
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34434140
51AR_21909140_ChIP-Seq_LNCAP_Human1.34170411
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.34105984
53SA1_27219007_Chip-Seq_ERYTHROID_Human1.33935727
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32518431
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.32432916
56FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.32398150
57* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31713740
58TCF7_22412390_ChIP-Seq_EML_Mouse1.31032914
59TRIM28_21343339_ChIP-Seq_HEK293_Human1.30644276
60* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29831865
61KDM2B_26808549_Chip-Seq_DND41_Human1.27531930
62NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.27325721
63SMC4_20622854_ChIP-Seq_HELA_Human1.26540721
64MYC_18358816_ChIP-ChIP_MESCs_Mouse1.25867746
65XRN2_22483619_ChIP-Seq_HELA_Human1.25576692
66TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24673487
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21727470
68KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21075118
69ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20674291
70KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19653496
71* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.19467327
72SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.19116504
73* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17916512
74NELFA_20434984_ChIP-Seq_ESCs_Mouse1.17634514
75SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17054647
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16698552
77CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.15405657
78NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14688134
79SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14639304
80TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14587398
81P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13519565
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13082530
83RUNX1_22412390_ChIP-Seq_EML_Mouse1.12618464
84MAF_26560356_Chip-Seq_TH2_Human1.12590746
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12045834
86GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10916851
87TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.09897913
88TCF3_18692474_ChIP-Seq_MEFs_Mouse1.08619191
89UTX_26944678_Chip-Seq_JUKART_Human1.07928652
90SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07705334
91NCOR1_26117541_ChIP-Seq_K562_Human1.07603188
92KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07507055
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05527792
94TFEB_21752829_ChIP-Seq_HELA_Human1.05486901
95MAF_26560356_Chip-Seq_TH1_Human1.04266022
96DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03574275
97KDM5A_27292631_Chip-Seq_BREAST_Human1.03098003
98ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02777493
99ELF1_20517297_ChIP-Seq_JURKAT_Human1.02734108
100UBF1/2_26484160_Chip-Seq_HMECs_Human1.01677141
101P68_20966046_ChIP-Seq_HELA_Human1.01210359
102RUNX1_27514584_Chip-Seq_MCF-7_Human1.00813443
103SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00784801
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00413667
105* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.99364498
106* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99038806
107CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98724371
108BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97788249
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97478795
110PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97369187
111TP53_22127205_ChIP-Seq_IMR90_Human0.96813992
112THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96370984
113DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95263060
114GATA6_25053715_ChIP-Seq_YYC3_Human0.94122840
115SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94061107
116ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93110650
117TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92637613
118CREB1_26743006_Chip-Seq_LNCaP_Human0.92538352
119E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92379318
120CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92254336
121RARA_24833708_ChIP-Seq_LIVER_Mouse0.91958151
122* NANOG_18555785_ChIP-Seq_MESCs_Mouse0.91925675
123GABP_19822575_ChIP-Seq_HepG2_Human0.91781166
124* GATA1_19941827_ChIP-Seq_MEL_Mouse0.91732743
125ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90873182
126UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.90655332
127CHD1_26751641_Chip-Seq_LNCaP_Human0.90278495
128FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.89198546
129TET1_21451524_ChIP-Seq_MESCs_Mouse0.89038166
130* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.87423754
131* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87135116
132TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.87001654
133BCOR_27268052_Chip-Seq_Bcells_Human0.85854347
134ZFP281_27345836_Chip-Seq_ESCs_Mouse0.85850297

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.06346400
2MP0002139_abnormal_hepatobiliary_system3.89306519
3MP0005360_urolithiasis3.89190605
4MP0009840_abnormal_foam_cell2.98537622
5MP0005365_abnormal_bile_salt2.98261405
6MP0005451_abnormal_body_composition2.92819162
7MP0008438_abnormal_cutaneous_collagen2.91040515
8MP0005085_abnormal_gallbladder_physiolo2.80063324
9MP0003806_abnormal_nucleotide_metabolis2.79958857
10MP0010352_gastrointestinal_tract_polyps2.60162111
11MP0004858_abnormal_nervous_system2.44443901
12MP0003252_abnormal_bile_duct2.44194537
13MP0003566_abnormal_cell_adhesion1.96774795
14MP0005409_darkened_coat_color1.86164653
15MP0001348_abnormal_lacrimal_gland1.82563867
16MP0008875_abnormal_xenobiotic_pharmacok1.82011585
17MP0003300_gastrointestinal_ulcer1.81845080
18MP0004185_abnormal_adipocyte_glucose1.80780688
19MP0010329_abnormal_lipoprotein_level1.79434490
20MP0005023_abnormal_wound_healing1.78873369
21MP0008260_abnormal_autophagy1.77991828
22MP0003283_abnormal_digestive_organ1.71994548
23MP0006054_spinal_hemorrhage1.71171694
24MP0005083_abnormal_biliary_tract1.70632817
25MP0000678_abnormal_parathyroid_gland1.63159799
26MP0005076_abnormal_cell_differentiation1.61824762
27MP0002877_abnormal_melanocyte_morpholog1.59698128
28MP0003191_abnormal_cellular_cholesterol1.55434826
29MP0002796_impaired_skin_barrier1.54584572
30MP0003329_amyloid_beta_deposits1.52714354
31MP0004233_abnormal_muscle_weight1.45602315
32MP0000609_abnormal_liver_physiology1.44006588
33MP0001666_abnormal_nutrient_absorption1.41908152
34MP0004264_abnormal_extraembryonic_tissu1.41486170
35MP0005332_abnormal_amino_acid1.41113503
36MP0009053_abnormal_anal_canal1.40503637
37MP0010030_abnormal_orbit_morphology1.39326848
38MP0004272_abnormal_basement_membrane1.36468808
39MP0000003_abnormal_adipose_tissue1.35999193
40MP0005501_abnormal_skin_physiology1.35821189
41MP0005275_abnormal_skin_tensile1.35588614
42MP0003279_aneurysm1.35194504
43MP0005058_abnormal_lysosome_morphology1.30921007
44MP0010234_abnormal_vibrissa_follicle1.30632155
45MP0005319_abnormal_enzyme/_coenzyme1.28456677
46MP0001730_embryonic_growth_arrest1.26309511
47MP0004957_abnormal_blastocyst_morpholog1.26308673
48MP0001849_ear_inflammation1.25186414
49MP0002249_abnormal_larynx_morphology1.24294329
50MP0000598_abnormal_liver_morphology1.22508428
51MP0002396_abnormal_hematopoietic_system1.21586426
52MP0010307_abnormal_tumor_latency1.21355196
53MP0005375_adipose_tissue_phenotype1.16518567
54MP0009643_abnormal_urine_homeostasis1.15561469
55MP0004197_abnormal_fetal_growth/weight/1.12856824
56MP0004947_skin_inflammation1.11143334
57MP0001958_emphysema1.08971830
58MP0001915_intracranial_hemorrhage1.08326584
59MP0004808_abnormal_hematopoietic_stem1.07974803
60MP0005220_abnormal_exocrine_pancreas1.07106586
61MP0005621_abnormal_cell_physiology1.05885201
62MP0002086_abnormal_extraembryonic_tissu1.03912489
63MP0003693_abnormal_embryo_hatching1.03223289
64MP0004019_abnormal_vitamin_homeostasis1.01680990
65MP0000767_abnormal_smooth_muscle1.01564598
66MP0003119_abnormal_digestive_system1.00790060
67MP0003984_embryonic_growth_retardation0.99546417
68MP0002088_abnormal_embryonic_growth/wei0.99538077
69MP0003115_abnormal_respiratory_system0.98773224
70MP0001672_abnormal_embryogenesis/_devel0.98611019
71MP0005380_embryogenesis_phenotype0.98611019
72MP0002118_abnormal_lipid_homeostasis0.95566236
73MP0000566_synostosis0.94566471
74MP0002089_abnormal_postnatal_growth/wei0.93386196
75MP0009931_abnormal_skin_appearance0.92878457
76MP0009384_cardiac_valve_regurgitation0.92339622
77MP0009672_abnormal_birth_weight0.91658014
78MP0000858_altered_metastatic_potential0.91584344
79MP0009333_abnormal_splenocyte_physiolog0.91481512
80MP0000467_abnormal_esophagus_morphology0.90666267
81MP0000350_abnormal_cell_proliferation0.90421830
82MP0002080_prenatal_lethality0.89417505
83MP0000534_abnormal_ureter_morphology0.89237099
84MP0003111_abnormal_nucleus_morphology0.88857739
85MP0001697_abnormal_embryo_size0.88506461
86MP0000751_myopathy0.88024452
87MP0000733_abnormal_muscle_development0.87631672
88MP0000490_abnormal_crypts_of0.86812273
89MP0003091_abnormal_cell_migration0.86336220
90MP0001216_abnormal_epidermal_layer0.85630384
91MP0002084_abnormal_developmental_patter0.85253972
92MP0002060_abnormal_skin_morphology0.84571698
93MP0003195_calcinosis0.84519587
94MP0009278_abnormal_bone_marrow0.83893931
95MP0002998_abnormal_bone_remodeling0.83595501
96MP0010630_abnormal_cardiac_muscle0.83192140
97MP0005623_abnormal_meninges_morphology0.82239456
98MP0003077_abnormal_cell_cycle0.82122675
99MP0001243_abnormal_dermal_layer0.81676830
100MP0003123_paternal_imprinting0.81348201
101MP0008961_abnormal_basal_metabolism0.81126372
102MP0003942_abnormal_urinary_system0.81029924
103MP0000747_muscle_weakness0.80744499
104MP0002896_abnormal_bone_mineralization0.80132102
105MP0000537_abnormal_urethra_morphology0.79384475
106MP0002085_abnormal_embryonic_tissue0.79361748
107MP0003172_abnormal_lysosome_physiology0.78075169
108MP0002653_abnormal_ependyma_morphology0.78035525
109MP0000477_abnormal_intestine_morphology0.76974924
110MP0003453_abnormal_keratinocyte_physiol0.76205410
111MP0005503_abnormal_tendon_morphology0.75883783
112MP0002697_abnormal_eye_size0.74806717
113MP0000604_amyloidosis0.72887195
114MP0006138_congestive_heart_failure0.72554577
115MP0005257_abnormal_intraocular_pressure0.71560623
116MP0002111_abnormal_tail_morphology0.71235919
117MP0000428_abnormal_craniofacial_morphol0.71064536
118MP0002092_abnormal_eye_morphology0.70858491
119MP0005384_cellular_phenotype0.70688368
120MP0003634_abnormal_glial_cell0.70557223
121MP0000681_abnormal_thyroid_gland0.69853280
122MP0010368_abnormal_lymphatic_system0.68973791
123MP0000759_abnormal_skeletal_muscle0.68827227
124MP0002269_muscular_atrophy0.68740038
125MP0001614_abnormal_blood_vessel0.68283712
126MP0005508_abnormal_skeleton_morphology0.68082887
127MP0003186_abnormal_redox_activity0.68053185
128MP0004782_abnormal_surfactant_physiolog0.67982673
129MP0003385_abnormal_body_wall0.67838989
130MP0005390_skeleton_phenotype0.67824193
131MP0002925_abnormal_cardiovascular_devel0.67724601
132MP0000462_abnormal_digestive_system0.67462937
133MP0000579_abnormal_nail_morphology0.67073171
134MP0001661_extended_life_span0.67042984
135MP0001756_abnormal_urination0.66383669
136MP0005464_abnormal_platelet_physiology0.66383265
137MP0002135_abnormal_kidney_morphology0.66257524
138MP0005670_abnormal_white_adipose0.66088118
139MP0003303_peritoneal_inflammation0.65097613
140MP0002138_abnormal_hepatobiliary_system0.63549378
141MP0003436_decreased_susceptibility_to0.63258958
142MP0002970_abnormal_white_adipose0.61191258
143MP0005666_abnormal_adipose_tissue0.60974185
144MP0002019_abnormal_tumor_incidence0.60431527
145MP0002928_abnormal_bile_duct0.60345917
146MP0003868_abnormal_feces_composition0.60309941
147MP0002136_abnormal_kidney_physiology0.59540929

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.49201066
2Deep venous thrombosis (HP:0002625)4.30753977
3Abnormality of monocarboxylic acid metabolism (HP:0010996)3.90752785
4Xanthomatosis (HP:0000991)3.50297325
5Premature rupture of membranes (HP:0001788)3.49123958
6Intrahepatic cholestasis (HP:0001406)3.42152060
7Abnormality of aromatic amino acid family metabolism (HP:0004338)3.28505749
8Cerebral aneurysm (HP:0004944)3.13315591
9Hypobetalipoproteinemia (HP:0003563)3.11695336
10Peritonitis (HP:0002586)2.99304408
11Spastic diplegia (HP:0001264)2.96491428
12Hand muscle atrophy (HP:0009130)2.79736782
13Cervical subluxation (HP:0003308)2.77989925
14Distal upper limb amyotrophy (HP:0007149)2.71540462
15Upper limb amyotrophy (HP:0009129)2.71540462
16Abnormality of glutamine family amino acid metabolism (HP:0010902)2.71012482
17Disproportionate tall stature (HP:0001519)2.70608365
18Broad face (HP:0000283)2.67957223
19Bladder diverticulum (HP:0000015)2.61116200
20Abnormality of sulfur amino acid metabolism (HP:0004339)2.58941898
21Fragile skin (HP:0001030)2.58365816
22Abnormality of the intrinsic pathway (HP:0010989)2.57299047
23Abnormality of the common coagulation pathway (HP:0010990)2.56875900
24Shallow orbits (HP:0000586)2.55696229
25Complement deficiency (HP:0004431)2.53820790
26Distal lower limb amyotrophy (HP:0008944)2.52931925
27Insomnia (HP:0100785)2.47860689
28Hypoglycemic coma (HP:0001325)2.47192395
29Abnormal cartilage morphology (HP:0002763)2.45040367
30Ulnar bowing (HP:0003031)2.42593869
31Increased connective tissue (HP:0009025)2.40569515
32Hypolipoproteinemia (HP:0010981)2.38649402
33Obstructive sleep apnea (HP:0002870)2.37284202
34Ankle contracture (HP:0006466)2.37113400
35Lymphangioma (HP:0100764)2.36267949
36Asymmetry of the thorax (HP:0001555)2.34429041
37Centrally nucleated skeletal muscle fibers (HP:0003687)2.28856417
38Multiple enchondromatosis (HP:0005701)2.28466303
39Hyperammonemia (HP:0001987)2.27912007
40Hyperacusis (HP:0010780)2.24248789
41Long palpebral fissure (HP:0000637)2.23415349
42Spinal rigidity (HP:0003306)2.22366587
43Abnormality of complement system (HP:0005339)2.20741613
44Abnormal gallbladder physiology (HP:0012438)2.20387344
45Cholecystitis (HP:0001082)2.20387344
46Late onset (HP:0003584)2.19655919
47Abnormality of pyrimidine metabolism (HP:0004353)2.18031054
48Wormian bones (HP:0002645)2.17693412
49Mitral valve prolapse (HP:0001634)2.17515359
50Distal lower limb muscle weakness (HP:0009053)2.16586393
51Genu recurvatum (HP:0002816)2.14423131
52Myocardial infarction (HP:0001658)2.14029361
53Turricephaly (HP:0000262)2.13891865
54Ketosis (HP:0001946)2.12639032
55Pseudobulbar signs (HP:0002200)2.10951617
56J-shaped sella turcica (HP:0002680)2.09865315
57Mitral regurgitation (HP:0001653)2.09793998
58Bowel diverticulosis (HP:0005222)2.09087714
59Hypoalphalipoproteinemia (HP:0003233)2.07016623
60Blue sclerae (HP:0000592)2.06738115
61Hemorrhage of the eye (HP:0011885)2.05225799
62Abnormality of dentin (HP:0010299)2.04583798
63Abnormality of the Achilles tendon (HP:0005109)2.02607517
64Metaphyseal cupping (HP:0003021)2.01487411
65Hyperlipoproteinemia (HP:0010980)2.00641109
66Hyperglycinuria (HP:0003108)1.99982560
67Mucopolysacchariduria (HP:0008155)1.98579894
68Urinary glycosaminoglycan excretion (HP:0003541)1.98579894
69Aortic dissection (HP:0002647)1.98373479
70* Aneurysm (HP:0002617)1.98137520
71Reticulocytosis (HP:0001923)1.97632807
72Dilatation of the ascending aorta (HP:0005111)1.97563113
73Abnormality of the thoracic spine (HP:0100711)1.97318808
74Trismus (HP:0000211)1.97168676
75Rectal prolapse (HP:0002035)1.97008569
76Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.96880910
77Ectopia lentis (HP:0001083)1.96326126
78Cerebral inclusion bodies (HP:0100314)1.94075787
79Abnormality of the acetabulum (HP:0003170)1.93639448
80Premature skin wrinkling (HP:0100678)1.92484521
81Abnormality of the distal phalanges of the toes (HP:0010182)1.91664778
82Increased variability in muscle fiber diameter (HP:0003557)1.91037903
83Skin nodule (HP:0200036)1.90094804
84Hepatocellular carcinoma (HP:0001402)1.88822639
85Elbow flexion contracture (HP:0002987)1.88737164
86Short nail (HP:0001799)1.88716515
87Flat acetabular roof (HP:0003180)1.88588923
88Osteolytic defects of the hand bones (HP:0009699)1.88518768
89Osteolytic defects of the phalanges of the hand (HP:0009771)1.88518768
90Arterial tortuosity (HP:0005116)1.87978144
91Aortic aneurysm (HP:0004942)1.86902863
92Ketoacidosis (HP:0001993)1.86266680
93Renal duplication (HP:0000075)1.85720721
94Esophageal varix (HP:0002040)1.85129318
95Global brain atrophy (HP:0002283)1.84862845
96Nonimmune hydrops fetalis (HP:0001790)1.84781220
97Biconcave vertebral bodies (HP:0004586)1.84739148
98Vascular tortuosity (HP:0004948)1.84664111
99Thin bony cortex (HP:0002753)1.83896214
100Ankyloglossia (HP:0010296)1.83503502
101Ependymoma (HP:0002888)1.83145938
102Bowing of the arm (HP:0006488)1.82910755
103Bowed forearm bones (HP:0003956)1.82910755
104Hallux valgus (HP:0001822)1.82144659
105Abnormality of polysaccharide metabolism (HP:0011012)1.81318676
106Abnormality of glycosaminoglycan metabolism (HP:0004371)1.81318676
107Abnormality of mucopolysaccharide metabolism (HP:0011020)1.81318676
108Abnormality of the peritoneum (HP:0002585)1.80185639
109Thin ribs (HP:0000883)1.79862236
110Selective tooth agenesis (HP:0001592)1.79591618
111Abnormality of the distal phalanx of the thumb (HP:0009617)1.79334410
112Abnormality of nucleobase metabolism (HP:0010932)1.79306544
113Hydroxyprolinuria (HP:0003080)1.78976719
114Abnormality of proline metabolism (HP:0010907)1.78976719
115Hyperparathyroidism (HP:0000843)1.78854908
116Mildly elevated creatine phosphokinase (HP:0008180)1.78831688
117Renovascular hypertension (HP:0100817)1.78106573
118Deviation of the hallux (HP:0010051)1.78028289
119Abnormality of glycine metabolism (HP:0010895)1.78019264
120Abnormality of serine family amino acid metabolism (HP:0010894)1.78019264
121Advanced eruption of teeth (HP:0006288)1.77967621
122Epidermoid cyst (HP:0200040)1.77782491
123Prolonged partial thromboplastin time (HP:0003645)1.77105310
124Malnutrition (HP:0004395)1.76976532
125Abnormality of oral frenula (HP:0000190)1.76936999
126Lower limb amyotrophy (HP:0007210)1.76431397
127Abnormality of skeletal muscle fiber size (HP:0012084)1.74631122
128Abnormality of the lower motor neuron (HP:0002366)1.74324524
129Increased mean platelet volume (HP:0011877)1.73796607
130Joint laxity (HP:0001388)1.73156938
131Patellar dislocation (HP:0002999)1.72927012
132Achilles tendon contracture (HP:0001771)1.72612779
133Hyperinsulinemic hypoglycemia (HP:0000825)1.72300266
134Atrophic scars (HP:0001075)1.72094800
135Dysostosis multiplex (HP:0000943)1.71753857
136Stridor (HP:0010307)1.71357925
137Coxa vara (HP:0002812)1.71340519
138Polygenic inheritance (HP:0010982)1.70918605
139Segmental peripheral demyelination/remyelination (HP:0003481)1.70841616
140Long toe (HP:0010511)1.70602772
141Gout (HP:0001997)1.70562437
142Joint hemorrhage (HP:0005261)1.70430048
143Vertebral clefting (HP:0008428)1.69971431
144Natal tooth (HP:0000695)1.69224573
145Vertebral compression fractures (HP:0002953)1.69210333
146Abnormality of endocrine pancreas physiology (HP:0012093)1.69156599
147Abnormality of the pancreatic islet cells (HP:0006476)1.69156599
148Mitral stenosis (HP:0001718)1.68941660
149Abnormal ossification of hand bones (HP:0005921)1.68482070
150Spinal cord lesions (HP:0100561)1.68085232
151Syringomyelia (HP:0003396)1.68085232
152Generalized amyotrophy (HP:0003700)1.67751443
153Hyperextensible skin (HP:0000974)1.67518518
154Abnormality of aspartate family amino acid metabolism (HP:0010899)1.67510429
155Neurofibrillary tangles (HP:0002185)1.67261742
156Arnold-Chiari malformation (HP:0002308)1.67021876
157Cellulitis (HP:0100658)1.62821441
158Pointed chin (HP:0000307)1.62598670
159Elfin facies (HP:0004428)1.60649800
160Overriding aorta (HP:0002623)1.60077695
161Cupped ribs (HP:0000887)1.59786881
162Broad distal phalanx of finger (HP:0009836)1.59473165
163Abnormality of carpal bone ossification (HP:0006257)1.59460901
164Dislocated radial head (HP:0003083)1.59242158
165Nuclear cataract (HP:0100018)1.57330118
166Broad metatarsal (HP:0001783)1.56226650
167Thoracic kyphosis (HP:0002942)1.55751512
168Hypercortisolism (HP:0001578)1.54708229

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.72314153
2ERN14.33902937
3SMG13.91943862
4PKN23.79901607
5EEF2K3.52680168
6PRPF4B3.05237422
7MAP3K102.86198604
8SIK12.35260869
9IRAK32.27650298
10CDK122.19610021
11PDGFRA2.04083902
12EPHA22.02863009
13PTK61.93007198
14BCKDK1.87160142
15DDR21.76691044
16PAK41.71254393
17RPS6KA41.68189347
18RIPK11.67178313
19SCYL21.64802959
20FGFR41.64029098
21PASK1.61573742
22LRRK21.61118688
23TTN1.60660086
24BMX1.58368684
25FLT31.56674924
26NTRK11.55047444
27NEK11.39754694
28STK101.37038390
29PTK21.36738672
30RPS6KB21.34341628
31TESK21.31076108
32NEK21.29953538
33MAP3K131.29382957
34MTOR1.26404686
35ICK1.25092304
36TAOK21.21002888
37MET1.17219499
38TESK11.14364695
39CDK61.13837078
40PAK21.10272531
41CDK41.06757118
42LATS11.05445801
43MAP2K31.03455252
44MAP3K81.03430020
45KSR21.00466121
46MAP3K111.00362563
47GRK60.98186611
48LATS20.98093162
49ALK0.95694305
50CDC42BPA0.94483934
51SIK20.93844972
52LMTK20.93602649
53PRKD30.92650276
54MARK20.92530426
55ARAF0.92396105
56MAP4K10.89390446
57CDK70.88995075
58KDR0.88657732
59MAPKAPK30.88304541
60CDC70.87489241
61RPS6KA20.87453784
62DYRK1B0.85353680
63PDPK10.80590019
64TYK20.80203315
65TTK0.78730650
66MAP3K10.76964680
67BUB10.76071550
68MAP2K20.75006850
69MAPK110.74043381
70TGFBR10.73692156
71FGFR10.71045596
72ZAP700.70695282
73RPS6KL10.69699646
74RPS6KC10.69699646
75MAP3K30.68175291
76TAOK30.66791614
77TBK10.66129028
78EPHB10.65241731
79NME20.64605432
80RIPK40.63627183
81HIPK20.63218832
82BRAF0.62600454
83PDGFRB0.61819050
84SIK30.60199171
85TYRO30.57445257
86MAP3K60.54695971
87IRAK20.53670660
88ILK0.53426323
89TGFBR20.53059511
90CDK90.52660195
91MAP3K140.52269652
92TAOK10.52055666
93BRD40.51399873
94MOS0.51086345
95PAK10.49975607
96AURKB0.49432787
97PIM20.47551487
98RET0.46657135
99IRAK40.46646998
100ERBB20.46014479
101CSF1R0.45868222
102PRKD20.45510813
103JAK30.45477642
104RPS6KA60.45461872
105AKT20.45111260
106CLK10.44986198
107CAMK1G0.44960562
108JAK20.44805374
109CHEK10.44627387
110PRKCI0.44513831
111CHUK0.43582676
112CAMK1D0.43558160
113VRK20.41148602
114CSK0.40648457
115PIM10.40374426
116WEE10.39838079
117ABL20.38399118
118MAP3K70.38209493
119FGFR30.38161180
120ATR0.37730249
121PRKG20.37191267
122MAPKAPK20.36637626
123PLK10.36187733
124MST1R0.36010842
125PRKCH0.35731300
126MAP3K90.35236258
127RPS6KA10.35177349
128STK30.35134553
129GSK3A0.34997780
130EPHB20.34864116
131PDK10.34746453
132AURKA0.34740165
133STK380.34674364
134FER0.34289433
135CDK20.34168534
136CDK11A0.33232131
137BTK0.33227156
138CAMKK10.32277965
139EGFR0.31672004

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.81315889
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.77778948
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.74802840
4Nitrogen metabolism_Homo sapiens_hsa009102.70630737
5Selenocompound metabolism_Homo sapiens_hsa004502.56650831
6Arginine biosynthesis_Homo sapiens_hsa002202.31639147
7One carbon pool by folate_Homo sapiens_hsa006702.23348883
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.22685838
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.14784526
10Acute myeloid leukemia_Homo sapiens_hsa052212.06484791
11Tryptophan metabolism_Homo sapiens_hsa003802.04962788
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.04123903
13Biosynthesis of amino acids_Homo sapiens_hsa012301.97076804
14Complement and coagulation cascades_Homo sapiens_hsa046101.90263210
15Fatty acid degradation_Homo sapiens_hsa000711.87825566
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.81161091
17Non-small cell lung cancer_Homo sapiens_hsa052231.73761595
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.60684925
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58752604
20Drug metabolism - other enzymes_Homo sapiens_hsa009831.56455748
21Carbon metabolism_Homo sapiens_hsa012001.56364564
22VEGF signaling pathway_Homo sapiens_hsa043701.55288056
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.54418877
24Pancreatic cancer_Homo sapiens_hsa052121.53790709
25Endometrial cancer_Homo sapiens_hsa052131.49455735
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.48045785
27Sulfur relay system_Homo sapiens_hsa041221.44629998
28Lysine degradation_Homo sapiens_hsa003101.43411706
29* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.39080062
30PPAR signaling pathway_Homo sapiens_hsa033201.34220725
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.33777852
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.33071980
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.32583560
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.29755166
35Galactose metabolism_Homo sapiens_hsa000521.29534051
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.29248057
37Folate biosynthesis_Homo sapiens_hsa007901.27673518
38Fatty acid metabolism_Homo sapiens_hsa012121.27133930
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.27113851
40Bladder cancer_Homo sapiens_hsa052191.25369115
41Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.24695853
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.24616298
43B cell receptor signaling pathway_Homo sapiens_hsa046621.23552548
44Thyroid hormone signaling pathway_Homo sapiens_hsa049191.22500157
45Neurotrophin signaling pathway_Homo sapiens_hsa047221.22276730
46Glioma_Homo sapiens_hsa052141.21953932
47Fat digestion and absorption_Homo sapiens_hsa049751.20760715
48Pentose phosphate pathway_Homo sapiens_hsa000301.20566770
49Renal cell carcinoma_Homo sapiens_hsa052111.20078765
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18967553
51Bile secretion_Homo sapiens_hsa049761.17685104
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17320338
53ErbB signaling pathway_Homo sapiens_hsa040121.13643499
54Starch and sucrose metabolism_Homo sapiens_hsa005001.13329189
55Insulin signaling pathway_Homo sapiens_hsa049101.12975185
56Pyruvate metabolism_Homo sapiens_hsa006201.12143320
57Caffeine metabolism_Homo sapiens_hsa002321.11498017
58Prostate cancer_Homo sapiens_hsa052151.10690734
59Chemical carcinogenesis_Homo sapiens_hsa052041.05455432
60Peroxisome_Homo sapiens_hsa041461.04562984
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01917005
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00991962
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98753344
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.97810526
65Arginine and proline metabolism_Homo sapiens_hsa003300.97517551
66Fructose and mannose metabolism_Homo sapiens_hsa000510.96514381
67Butanoate metabolism_Homo sapiens_hsa006500.96273952
68Staphylococcus aureus infection_Homo sapiens_hsa051500.95598569
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.94540597
70DNA replication_Homo sapiens_hsa030300.93854145
71Hepatitis B_Homo sapiens_hsa051610.93648772
72Phenylalanine metabolism_Homo sapiens_hsa003600.91770082
73Estrogen signaling pathway_Homo sapiens_hsa049150.90744405
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.90564046
75Apoptosis_Homo sapiens_hsa042100.90358105
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88558010
77beta-Alanine metabolism_Homo sapiens_hsa004100.87470138
78Colorectal cancer_Homo sapiens_hsa052100.87437833
79Hepatitis C_Homo sapiens_hsa051600.87336997
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86037031
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.85900815
82Shigellosis_Homo sapiens_hsa051310.84902396
83Sulfur metabolism_Homo sapiens_hsa009200.84333828
84Histidine metabolism_Homo sapiens_hsa003400.83865545
85GnRH signaling pathway_Homo sapiens_hsa049120.83271046
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.83076635
87HTLV-I infection_Homo sapiens_hsa051660.80728377
88Small cell lung cancer_Homo sapiens_hsa052220.80638517
89Propanoate metabolism_Homo sapiens_hsa006400.80066515
90Prolactin signaling pathway_Homo sapiens_hsa049170.79243999
91Endocytosis_Homo sapiens_hsa041440.78886882
92Chronic myeloid leukemia_Homo sapiens_hsa052200.78523195
93Vibrio cholerae infection_Homo sapiens_hsa051100.77479561
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76690581
95Choline metabolism in cancer_Homo sapiens_hsa052310.76416455
96ECM-receptor interaction_Homo sapiens_hsa045120.73765794
97HIF-1 signaling pathway_Homo sapiens_hsa040660.73429581
98N-Glycan biosynthesis_Homo sapiens_hsa005100.73325386
99Osteoclast differentiation_Homo sapiens_hsa043800.72710236
100Toxoplasmosis_Homo sapiens_hsa051450.72336634
101Steroid hormone biosynthesis_Homo sapiens_hsa001400.71945452
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71178071
103Influenza A_Homo sapiens_hsa051640.69934163
104Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68412526
105Glutathione metabolism_Homo sapiens_hsa004800.68389711
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68033283
107mRNA surveillance pathway_Homo sapiens_hsa030150.67139589
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66565072
109Insulin resistance_Homo sapiens_hsa049310.65770937
110Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65636106
111Retinol metabolism_Homo sapiens_hsa008300.64571250
112ABC transporters_Homo sapiens_hsa020100.64107151
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.64062523
114Inositol phosphate metabolism_Homo sapiens_hsa005620.62553471
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61579180
116Proteoglycans in cancer_Homo sapiens_hsa052050.61217480
117Tyrosine metabolism_Homo sapiens_hsa003500.60462562
118RNA transport_Homo sapiens_hsa030130.59854713
119TNF signaling pathway_Homo sapiens_hsa046680.59797480
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59238323
121Pathways in cancer_Homo sapiens_hsa052000.59222064
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58573870
123Base excision repair_Homo sapiens_hsa034100.58353257
124Prion diseases_Homo sapiens_hsa050200.57974720
125Salmonella infection_Homo sapiens_hsa051320.57772422
126Vitamin digestion and absorption_Homo sapiens_hsa049770.57442441
127Spliceosome_Homo sapiens_hsa030400.57055845
128Mismatch repair_Homo sapiens_hsa034300.56629341
129Melanogenesis_Homo sapiens_hsa049160.55788796
130Focal adhesion_Homo sapiens_hsa045100.55719302
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55574427
132Other glycan degradation_Homo sapiens_hsa005110.54716934
133Lysosome_Homo sapiens_hsa041420.54170597
134Notch signaling pathway_Homo sapiens_hsa043300.53358461
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53295170
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53026614
137Protein digestion and absorption_Homo sapiens_hsa049740.51545157
138T cell receptor signaling pathway_Homo sapiens_hsa046600.50787820
139Thyroid cancer_Homo sapiens_hsa052160.50764436
140Melanoma_Homo sapiens_hsa052180.50450822
141Adherens junction_Homo sapiens_hsa045200.50075978
142p53 signaling pathway_Homo sapiens_hsa041150.48860100
143Amoebiasis_Homo sapiens_hsa051460.47617711
144Leishmaniasis_Homo sapiens_hsa051400.47499017
145Rap1 signaling pathway_Homo sapiens_hsa040150.46401011
146Herpes simplex infection_Homo sapiens_hsa051680.45092123
147mTOR signaling pathway_Homo sapiens_hsa041500.44144553
148Hippo signaling pathway_Homo sapiens_hsa043900.43108292
149MicroRNAs in cancer_Homo sapiens_hsa052060.42565217
150Viral carcinogenesis_Homo sapiens_hsa052030.40334557
151Adipocytokine signaling pathway_Homo sapiens_hsa049200.39067134
152AMPK signaling pathway_Homo sapiens_hsa041520.38337377
153Basal cell carcinoma_Homo sapiens_hsa052170.38331007
154Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37562063
155Antigen processing and presentation_Homo sapiens_hsa046120.35768724
156Legionellosis_Homo sapiens_hsa051340.35319430
157Cell cycle_Homo sapiens_hsa041100.35056125
158Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34224629

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