PRKCZ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.92797922
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.72860724
3locomotory exploration behavior (GO:0035641)5.56699375
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.20174513
5* positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.14554710
6synaptic vesicle exocytosis (GO:0016079)5.07134378
7vocalization behavior (GO:0071625)4.93850544
8glutamate secretion (GO:0014047)4.86991729
9regulation of synaptic vesicle exocytosis (GO:2000300)4.81371021
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.70931090
11neuronal action potential propagation (GO:0019227)4.70535398
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.40945621
13amino acid import (GO:0043090)4.38306404
14regulation of glutamate receptor signaling pathway (GO:1900449)4.34180892
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.29248924
16regulation of neuronal synaptic plasticity (GO:0048168)4.27313218
17neurotransmitter secretion (GO:0007269)4.24735712
18protein localization to synapse (GO:0035418)4.24596044
19regulation of synaptic vesicle transport (GO:1902803)4.20193055
20regulation of synapse structural plasticity (GO:0051823)4.19530761
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.16350607
22neuron cell-cell adhesion (GO:0007158)4.10698897
23exploration behavior (GO:0035640)4.10465698
24cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.03877312
25synaptic transmission, glutamatergic (GO:0035249)4.03638370
26gamma-aminobutyric acid transport (GO:0015812)3.98130289
27regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.96369633
28layer formation in cerebral cortex (GO:0021819)3.95691857
29neuron-neuron synaptic transmission (GO:0007270)3.92055207
30dendritic spine morphogenesis (GO:0060997)3.91562034
31regulation of synapse maturation (GO:0090128)3.89248743
32regulation of ARF protein signal transduction (GO:0032012)3.88056296
33neurotransmitter-gated ion channel clustering (GO:0072578)3.87824461
34cytoskeletal anchoring at plasma membrane (GO:0007016)3.80110107
35transmission of nerve impulse (GO:0019226)3.80017985
36positive regulation of dendritic spine morphogenesis (GO:0061003)3.78872512
37glutamate receptor signaling pathway (GO:0007215)3.78844011
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.78222959
39postsynaptic membrane organization (GO:0001941)3.73579613
40cell communication by electrical coupling (GO:0010644)3.68703147
41axon ensheathment in central nervous system (GO:0032291)3.62519045
42central nervous system myelination (GO:0022010)3.62519045
43regulation of dendritic spine morphogenesis (GO:0061001)3.62503559
44cellular potassium ion homeostasis (GO:0030007)3.62025743
45negative regulation of dendrite morphogenesis (GO:0050774)3.61960743
46neuromuscular process controlling balance (GO:0050885)3.58468447
47cellular sodium ion homeostasis (GO:0006883)3.56470017
48* positive regulation of membrane potential (GO:0045838)3.55855197
49potassium ion homeostasis (GO:0055075)3.54882770
50neurotransmitter transport (GO:0006836)3.54605676
51neuromuscular process controlling posture (GO:0050884)3.49251812
52* regulation of excitatory postsynaptic membrane potential (GO:0060079)3.48195209
53* long-term memory (GO:0007616)3.47683098
54prepulse inhibition (GO:0060134)3.46861486
55glycine transport (GO:0015816)3.46518174
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.44570442
57neuronal ion channel clustering (GO:0045161)3.43036278
58* regulation of synaptic plasticity (GO:0048167)3.37805059
59regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.36720497
60acidic amino acid transport (GO:0015800)3.36576458
61potassium ion import (GO:0010107)3.35851093
62L-amino acid import (GO:0043092)3.34689862
63auditory behavior (GO:0031223)3.31392069
64sodium ion export (GO:0071436)3.30782796
65behavioral response to cocaine (GO:0048148)3.29819042
66positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.29501940
67positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.28952227
68adult walking behavior (GO:0007628)3.28865877
69cerebellar granule cell differentiation (GO:0021707)3.28473025
70regulation of neurotransmitter levels (GO:0001505)3.28445944
71regulation of neurotransmitter secretion (GO:0046928)3.28048710
72* regulation of postsynaptic membrane potential (GO:0060078)3.27405930
73regulation of voltage-gated calcium channel activity (GO:1901385)3.25702544
74negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.24420851
75cell communication involved in cardiac conduction (GO:0086065)3.21395112
76neuron recognition (GO:0008038)3.19216602
77regulation of synaptic transmission, glutamatergic (GO:0051966)3.18090679
78establishment of synaptic vesicle localization (GO:0097480)3.16162887
79synaptic vesicle transport (GO:0048489)3.16162887
80positive regulation of synaptic transmission, GABAergic (GO:0032230)3.15269062
81gamma-aminobutyric acid signaling pathway (GO:0007214)3.14547188
82dicarboxylic acid transport (GO:0006835)3.14207338
83dendrite morphogenesis (GO:0048813)3.14070761
84regulation of neurotransmitter transport (GO:0051588)3.11800095
85activation of protein kinase A activity (GO:0034199)3.11634214
86presynaptic membrane organization (GO:0097090)3.11166951
87positive regulation of synapse maturation (GO:0090129)3.10631977
88positive regulation of neurotransmitter transport (GO:0051590)3.10438948
89presynaptic membrane assembly (GO:0097105)3.07736019
90regulation of vesicle fusion (GO:0031338)3.05136213
91synaptic vesicle endocytosis (GO:0048488)3.05118707
92G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.04920550
93* long-term synaptic potentiation (GO:0060291)3.04541272
94response to auditory stimulus (GO:0010996)3.03413652
95regulation of dendritic spine development (GO:0060998)3.03082195
96signal release (GO:0023061)3.02362392
97mating behavior (GO:0007617)3.02348896
98cerebellar Purkinje cell differentiation (GO:0021702)3.01785523
99negative regulation of synaptic transmission, GABAergic (GO:0032229)3.00364239
100neurotransmitter uptake (GO:0001504)2.99671200
101establishment of mitochondrion localization (GO:0051654)2.98768744
102proline transport (GO:0015824)2.98659662
103G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.96651284
104acid secretion (GO:0046717)2.96222097
105* membrane hyperpolarization (GO:0060081)2.95968827
106L-glutamate transport (GO:0015813)2.95836786
107neuromuscular process (GO:0050905)2.95260724
108dendritic spine organization (GO:0097061)2.93606530
109vesicle docking involved in exocytosis (GO:0006904)2.93053250
110calcium ion-dependent exocytosis (GO:0017156)2.92376177
111positive regulation of dendrite development (GO:1900006)2.92197605
112positive regulation of dendritic spine development (GO:0060999)2.91417696
113synaptic transmission, dopaminergic (GO:0001963)2.90661554
114* membrane depolarization (GO:0051899)2.90556014
115axonal fasciculation (GO:0007413)2.90175851
116regulation of exocytosis (GO:0017157)2.89963720
117learning (GO:0007612)2.89658740
118positive regulation of neurotransmitter secretion (GO:0001956)2.89314152
119chemosensory behavior (GO:0007635)2.87498899
120long term synaptic depression (GO:0060292)2.85531844
121membrane depolarization during action potential (GO:0086010)2.85052859
122synapse assembly (GO:0007416)2.82472604
123regulation of glutamate secretion (GO:0014048)2.81273322
124* regulation of synaptic transmission (GO:0050804)2.80666325
125cell migration in hindbrain (GO:0021535)2.80551178
126synaptic transmission (GO:0007268)2.80235583
127striatum development (GO:0021756)2.76820700
128positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.76626731
129mechanosensory behavior (GO:0007638)2.76000385

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.07474079
2GBX2_23144817_ChIP-Seq_PC3_Human3.15996422
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.05878539
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.02975492
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.92940287
6* RARB_27405468_Chip-Seq_BRAIN_Mouse2.86140119
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.80337682
8REST_21632747_ChIP-Seq_MESCs_Mouse2.72265911
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.70138840
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.70138840
11* DROSHA_22980978_ChIP-Seq_HELA_Human2.62648397
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60502854
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.59171944
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.58318216
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46741100
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40593871
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.38316176
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36559326
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.35182114
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.34479806
21* REST_18959480_ChIP-ChIP_MESCs_Mouse2.27864547
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.22549868
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.11687437
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.11641902
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.10224144
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06068325
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.93177384
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.91187606
29AR_21572438_ChIP-Seq_LNCaP_Human1.87928186
30RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.84126802
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.83818350
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83615230
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.78613250
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.62497532
35LXR_22292898_ChIP-Seq_THP-1_Human1.61812957
36TAF15_26573619_Chip-Seq_HEK293_Human1.51036287
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50872908
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47892197
39* SMC4_20622854_ChIP-Seq_HELA_Human1.42140353
40* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41577050
41SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.41014766
42ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.40848836
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39873064
44ZFP281_27345836_Chip-Seq_ESCs_Mouse1.39370984
45DNAJC2_21179169_ChIP-ChIP_NT2_Human1.39103068
46* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.36002518
47SMAD4_21799915_ChIP-Seq_A2780_Human1.34740968
48CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28310820
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.28252862
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28074741
51P53_22127205_ChIP-Seq_FIBROBLAST_Human1.26136712
52* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24518986
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24400193
54* OCT4_19829295_ChIP-Seq_ESCs_Human1.21761769
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19914648
56* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19482519
57* SOX2_21211035_ChIP-Seq_LN229_Gbm1.19092061
58CREB1_26743006_Chip-Seq_LNCaP_Human1.18847498
59P68_20966046_ChIP-Seq_HELA_Human1.18356410
60* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17599663
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16715254
62ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.16582844
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.15138234
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14869850
65* KDM2B_26808549_Chip-Seq_K562_Human1.13906711
66STAT3_23295773_ChIP-Seq_U87_Human1.13552029
67SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12652250
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11959427
69* AR_19668381_ChIP-Seq_PC3_Human1.11922132
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09087582
71* RING1B_27294783_Chip-Seq_NPCs_Mouse1.08432436
72ZNF274_21170338_ChIP-Seq_K562_Hela1.07749788
73* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07628782
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07584916
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06941072
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06901196
77P300_19829295_ChIP-Seq_ESCs_Human1.04385047
78SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04119373
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02568096
80ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02098919
81WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02034592
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01568997
83PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01400444
84CBX2_27304074_Chip-Seq_ESCs_Mouse0.99839381
85* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99772324
86* CTCF_27219007_Chip-Seq_Bcells_Human0.99089174
87TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98438778
88ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98308822
89AR_25329375_ChIP-Seq_VCAP_Human0.97725888
90GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97653093
91* TET1_21490601_ChIP-Seq_MESCs_Mouse0.97560989
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97214475
93PIAS1_25552417_ChIP-Seq_VCAP_Human0.97176126
94UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97154745
95CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97079985
96BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96946419
97TCF4_23295773_ChIP-Seq_U87_Human0.96924226
98AHR_22903824_ChIP-Seq_MCF-7_Human0.95568632
99* TET1_21451524_ChIP-Seq_MESCs_Mouse0.94976505
100SMAD4_21741376_ChIP-Seq_HESCs_Human0.94418215
101SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94208671
102SMAD3_21741376_ChIP-Seq_HESCs_Human0.93352297
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93044451
104ARNT_22903824_ChIP-Seq_MCF-7_Human0.92685641
105CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91889005
106SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90668154
107SMAD3_21741376_ChIP-Seq_ESCs_Human0.88269859
108GATA1_26923725_Chip-Seq_HPCs_Mouse0.87782185
109KDM2B_26808549_Chip-Seq_DND41_Human0.87434693
110YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87183388
111SA1_27219007_Chip-Seq_ERYTHROID_Human0.86304967
112AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85943684
113RNF2_27304074_Chip-Seq_NSC_Mouse0.85447274
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85418272
115ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85043630
116PRDM14_20953172_ChIP-Seq_ESCs_Human0.84651175
117RACK7_27058665_Chip-Seq_MCF-7_Human0.84606508
118* SMAD4_21741376_ChIP-Seq_ESCs_Human0.84313668
119DPY_21335234_ChIP-Seq_ESCs_Mouse0.84225541
120RUNX2_22187159_ChIP-Seq_PCA_Human0.83072248
121NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.82908647
122* TP63_22573176_ChIP-Seq_HFKS_Human0.82907711
123NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82076046
124SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.81435333
125CTCF_20526341_ChIP-Seq_ESCs_Human0.81110613
126TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.80596864
127SMAD4_21741376_ChIP-Seq_EPCs_Human0.80560898
128* KLF4_19829295_ChIP-Seq_ESCs_Human0.80513659
129RUNX1_26923725_Chip-Seq_HPCs_Mouse0.80215325
130RXR_22108803_ChIP-Seq_LS180_Human0.79452921
131SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.78501563
132* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.78237880
133ESR1_21235772_ChIP-Seq_MCF-7_Human0.78209141
134OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.77739851
135* SA1_27219007_Chip-Seq_Bcells_Human0.77085721
136TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.75744654
137EGR1_19032775_ChIP-ChIP_M12_Human0.75564698
138TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.75479037
139NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.75435122
140PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.74328438
141CTCF_27219007_Chip-Seq_ERYTHROID_Human0.73094696

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.26815470
2MP0003880_abnormal_central_pattern4.57916272
3MP0003635_abnormal_synaptic_transmissio3.99246624
4MP0004270_analgesia3.98373591
5MP0002822_catalepsy3.94109206
6MP0009745_abnormal_behavioral_response3.36109442
7MP0002064_seizures3.22084259
8MP0009046_muscle_twitch3.19200022
9MP0002063_abnormal_learning/memory/cond3.17940734
10MP0005423_abnormal_somatic_nervous2.92949233
11MP0002272_abnormal_nervous_system2.83946234
12MP0001486_abnormal_startle_reflex2.76605587
13MP0001968_abnormal_touch/_nociception2.72847789
14MP0002572_abnormal_emotion/affect_behav2.67219794
15MP0002734_abnormal_mechanical_nocicepti2.66937063
16MP0003329_amyloid_beta_deposits2.27464907
17MP0001440_abnormal_grooming_behavior2.08496725
18MP0002736_abnormal_nociception_after2.06355026
19MP0001501_abnormal_sleep_pattern2.04031174
20MP0008569_lethality_at_weaning2.03069464
21MP0004885_abnormal_endolymph2.02237426
22MP0002735_abnormal_chemical_nociception1.99071915
23MP0002733_abnormal_thermal_nociception1.98781072
24MP0001970_abnormal_pain_threshold1.96174757
25MP0002067_abnormal_sensory_capabilities1.89857563
26MP0000920_abnormal_myelination1.83654796
27MP0000778_abnormal_nervous_system1.79482219
28MP0004924_abnormal_behavior1.77059669
29MP0005386_behavior/neurological_phenoty1.77059669
30MP0001529_abnormal_vocalization1.66642322
31MP0004811_abnormal_neuron_physiology1.66190298
32MP0009780_abnormal_chondrocyte_physiolo1.66005414
33MP0000955_abnormal_spinal_cord1.63692928
34MP0002557_abnormal_social/conspecific_i1.63275599
35MP0002184_abnormal_innervation1.63251453
36MP0004142_abnormal_muscle_tone1.57014666
37MP0004858_abnormal_nervous_system1.51538052
38MP0002066_abnormal_motor_capabilities/c1.50802146
39MP0002882_abnormal_neuron_morphology1.49068605
40MP0001984_abnormal_olfaction1.48803543
41MP0003123_paternal_imprinting1.48634148
42MP0002909_abnormal_adrenal_gland1.47935807
43MP0003879_abnormal_hair_cell1.47612922
44MP0001905_abnormal_dopamine_level1.44697348
45MP0003633_abnormal_nervous_system1.40919048
46MP0003690_abnormal_glial_cell1.40289816
47MP0005646_abnormal_pituitary_gland1.38817791
48MP0002229_neurodegeneration1.32386223
49MP0003631_nervous_system_phenotype1.28558505
50MP0004742_abnormal_vestibular_system1.27640920
51MP0004043_abnormal_pH_regulation1.25647791
52MP0000566_synostosis1.24800140
53MP0005551_abnormal_eye_electrophysiolog1.23292177
54MP0003634_abnormal_glial_cell1.19489618
55MP0003632_abnormal_nervous_system1.12667531
56MP0001502_abnormal_circadian_rhythm1.10635356
57MP0006276_abnormal_autonomic_nervous1.10052118
58MP0002152_abnormal_brain_morphology1.09397000
59MP0008872_abnormal_physiological_respon1.08323160
60MP0001346_abnormal_lacrimal_gland1.04734220
61MP0000604_amyloidosis1.04286337
62MP0001177_atelectasis1.03176058
63MP0001485_abnormal_pinna_reflex1.02643862
64MP0000579_abnormal_nail_morphology1.01344857
65MP0005645_abnormal_hypothalamus_physiol1.00687035
66MP0008874_decreased_physiological_sensi0.97150895
67MP0002069_abnormal_eating/drinking_beha0.97038155
68MP0002249_abnormal_larynx_morphology0.96756154
69MP0008877_abnormal_DNA_methylation0.93316531
70MP0003075_altered_response_to0.92248922
71MP0003787_abnormal_imprinting0.91258372
72MP0001348_abnormal_lacrimal_gland0.90976745
73MP0004145_abnormal_muscle_electrophysio0.89800145
74MP0001963_abnormal_hearing_physiology0.89680528
75MP0002752_abnormal_somatic_nervous0.86686893
76MP0002090_abnormal_vision0.80821203
77MP0005535_abnormal_body_temperature0.79050017
78MP0000013_abnormal_adipose_tissue0.77302289
79MP0005409_darkened_coat_color0.76656056
80MP0003283_abnormal_digestive_organ0.75336158
81MP0001188_hyperpigmentation0.75081415
82MP0004085_abnormal_heartbeat0.74219399
83MP0003121_genomic_imprinting0.71820579
84MP0000678_abnormal_parathyroid_gland0.71729502
85MP0001986_abnormal_taste_sensitivity0.69376994
86MP0001664_abnormal_digestion0.67342028
87MP0005167_abnormal_blood-brain_barrier0.67083474
88MP0000751_myopathy0.66688071
89MP0005499_abnormal_olfactory_system0.64894499
90MP0005394_taste/olfaction_phenotype0.64894499
91MP0003698_abnormal_male_reproductive0.64081761
92MP0003137_abnormal_impulse_conducting0.63775852
93MP0002089_abnormal_postnatal_growth/wei0.63374457
94MP0003878_abnormal_ear_physiology0.62721539
95MP0005377_hearing/vestibular/ear_phenot0.62721539
96MP0000747_muscle_weakness0.60634568
97MP0000631_abnormal_neuroendocrine_gland0.60131719
98MP0003938_abnormal_ear_development0.59495225
99MP0008260_abnormal_autophagy0.59229695
100MP0003183_abnormal_peptide_metabolism0.59066282
101MP0003122_maternal_imprinting0.58109742
102MP0005410_abnormal_fertilization0.57156099
103MP0008961_abnormal_basal_metabolism0.56626147
104MP0004147_increased_porphyrin_level0.54790229
105MP0001299_abnormal_eye_distance/0.54748824
106MP0010769_abnormal_survival0.53526661
107MP0001943_abnormal_respiration0.52380170
108MP0001765_abnormal_ion_homeostasis0.52268337
109MP0003861_abnormal_nervous_system0.51441718
110MP0005623_abnormal_meninges_morphology0.50935841
111MP0003956_abnormal_body_size0.50848280
112MP0002082_postnatal_lethality0.50716354
113MP0010770_preweaning_lethality0.50716354
114MP0010768_mortality/aging0.49986704
115MP0010386_abnormal_urinary_bladder0.49740628
116MP0010234_abnormal_vibrissa_follicle0.49316891
117MP0002653_abnormal_ependyma_morphology0.48968476
118MP0006072_abnormal_retinal_apoptosis0.47366965

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.66581294
2Focal motor seizures (HP:0011153)6.89154410
3Focal seizures (HP:0007359)5.26577448
4Visual hallucinations (HP:0002367)4.62428913
5Action tremor (HP:0002345)4.31109822
6Atonic seizures (HP:0010819)4.18521076
7Epileptic encephalopathy (HP:0200134)4.15217293
8Ankle clonus (HP:0011448)4.10089720
9Supranuclear gaze palsy (HP:0000605)3.94126132
10Progressive cerebellar ataxia (HP:0002073)3.88571313
11Dysmetria (HP:0001310)3.67015452
12Neurofibrillary tangles (HP:0002185)3.63847720
13Absence seizures (HP:0002121)3.61332095
14Febrile seizures (HP:0002373)3.57124857
15Intention tremor (HP:0002080)3.52174219
16Spastic gait (HP:0002064)3.49308022
17Generalized tonic-clonic seizures (HP:0002069)3.45404956
18Dialeptic seizures (HP:0011146)3.42646904
19Broad-based gait (HP:0002136)3.42413833
20Scanning speech (HP:0002168)3.35808242
21Dysdiadochokinesis (HP:0002075)3.34376635
22Gaze-evoked nystagmus (HP:0000640)3.32205550
23Impaired vibration sensation in the lower limbs (HP:0002166)3.21224449
24Abnormality of the corticospinal tract (HP:0002492)3.18740440
25Poor eye contact (HP:0000817)3.14911513
26Obstructive sleep apnea (HP:0002870)3.12265161
27Cerebral inclusion bodies (HP:0100314)3.09517130
28Anxiety (HP:0000739)3.04294127
29Depression (HP:0000716)3.04238284
30Impaired social interactions (HP:0000735)2.99031112
31Abnormal social behavior (HP:0012433)2.99031112
32Urinary bladder sphincter dysfunction (HP:0002839)2.97286046
33Abnormal eating behavior (HP:0100738)2.97059779
34Torticollis (HP:0000473)2.96856130
35Urinary urgency (HP:0000012)2.94224745
36Postural instability (HP:0002172)2.92718839
37Hyperventilation (HP:0002883)2.88963460
38Tetraplegia (HP:0002445)2.82975543
39Degeneration of the lateral corticospinal tracts (HP:0002314)2.77531221
40Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.77531221
41Mutism (HP:0002300)2.74766877
42Focal dystonia (HP:0004373)2.73756712
43Truncal ataxia (HP:0002078)2.72341260
44Megalencephaly (HP:0001355)2.60934325
45Termporal pattern (HP:0011008)2.58352246
46Insidious onset (HP:0003587)2.58352246
47Sleep apnea (HP:0010535)2.54262761
48Craniofacial dystonia (HP:0012179)2.53968267
49Apathy (HP:0000741)2.53668050
50Pheochromocytoma (HP:0002666)2.52251629
51Clonus (HP:0002169)2.48022615
52Progressive inability to walk (HP:0002505)2.47219824
53Peripheral hypomyelination (HP:0007182)2.45546990
54Bronchomalacia (HP:0002780)2.42235333
55Ventricular fibrillation (HP:0001663)2.41741852
56Lower limb muscle weakness (HP:0007340)2.41286984
57Abnormality of the lower motor neuron (HP:0002366)2.37005639
58Limb dystonia (HP:0002451)2.35565224
59Hand muscle atrophy (HP:0009130)2.35391808
60Annular pancreas (HP:0001734)2.33799142
61Hemiparesis (HP:0001269)2.33650311
62Fetal akinesia sequence (HP:0001989)2.33206603
63Onion bulb formation (HP:0003383)2.32071685
64Diminished motivation (HP:0000745)2.28767219
65Impaired smooth pursuit (HP:0007772)2.28207258
66Rapidly progressive (HP:0003678)2.27358929
67Amblyopia (HP:0000646)2.26960208
68Status epilepticus (HP:0002133)2.26674936
69Bradykinesia (HP:0002067)2.26352671
70Stereotypic behavior (HP:0000733)2.25459988
71Cerebral hypomyelination (HP:0006808)2.25182527
72Upper limb amyotrophy (HP:0009129)2.24622489
73Distal upper limb amyotrophy (HP:0007149)2.24622489
74Papilledema (HP:0001085)2.23468827
75Impaired vibratory sensation (HP:0002495)2.23443182
76Increased circulating renin level (HP:0000848)2.23360343
77Generalized myoclonic seizures (HP:0002123)2.23310984
78Akinesia (HP:0002304)2.22476878
79Abnormality of binocular vision (HP:0011514)2.21995199
80Diplopia (HP:0000651)2.21995199
81Drooling (HP:0002307)2.21328942
82Excessive salivation (HP:0003781)2.21328942
83Genetic anticipation (HP:0003743)2.18805024
84Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.18508431
85Spastic tetraparesis (HP:0001285)2.13820769
86Epileptiform EEG discharges (HP:0011182)2.12979033
87Abnormality of saccadic eye movements (HP:0000570)2.12350034
88Sensory axonal neuropathy (HP:0003390)2.11538355
89EEG with generalized epileptiform discharges (HP:0011198)2.10334677
90Neuroendocrine neoplasm (HP:0100634)2.10024139
91Hemiplegia (HP:0002301)2.08382953
92CNS hypomyelination (HP:0003429)2.07287709
93Hypsarrhythmia (HP:0002521)2.05781433
94Resting tremor (HP:0002322)2.05491922
95Dysmetric saccades (HP:0000641)2.05277086
96Neuronal loss in central nervous system (HP:0002529)2.05015373
97Lower limb amyotrophy (HP:0007210)2.02673353
98Abnormality of ocular smooth pursuit (HP:0000617)2.01982368
99Choreoathetosis (HP:0001266)2.01882805
100Rigidity (HP:0002063)2.01588029
101Delusions (HP:0000746)1.99406457
102Amyotrophic lateral sclerosis (HP:0007354)1.98887452
103Bundle branch block (HP:0011710)1.96739064
104Split foot (HP:0001839)1.96292137
105Absent speech (HP:0001344)1.95999375
106Gait ataxia (HP:0002066)1.94384115
107Polyphagia (HP:0002591)1.94157114
108Incomplete penetrance (HP:0003829)1.89797953
109Lower limb asymmetry (HP:0100559)1.89760201
110Metabolic alkalosis (HP:0200114)1.88134400
111Morphological abnormality of the pyramidal tract (HP:0002062)1.87588010
112Hammertoe (HP:0001765)1.84708720
113Distal sensory impairment (HP:0002936)1.84214524
114Aplasia involving bones of the upper limbs (HP:0009823)1.82523382
115Aplasia of the phalanges of the hand (HP:0009802)1.82523382
116Aplasia involving bones of the extremities (HP:0009825)1.82523382
117Blue irides (HP:0000635)1.80314487
118Insomnia (HP:0100785)1.78562432
119Psychosis (HP:0000709)1.77411755
120Decreased motor nerve conduction velocity (HP:0003431)1.76906102
121Thickened helices (HP:0000391)1.76462937
122Specific learning disability (HP:0001328)1.74829964
123Postural tremor (HP:0002174)1.74511537
124Inability to walk (HP:0002540)1.74237643
125Dementia (HP:0000726)1.72188489

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.61391530
2NTRK33.65089233
3MAP3K93.60405932
4MARK12.90329721
5DAPK22.60625215
6MAP3K42.43227141
7KSR22.39541368
8PAK62.37982426
9MINK12.31507955
10RIPK12.22482898
11OXSR12.17430565
12NTRK12.04398146
13PRKD32.01254215
14CDK191.92160088
15STK391.90074731
16NTRK21.81946564
17MAP2K71.79726181
18CAMKK11.78612664
19PRPF4B1.75435170
20TNIK1.63584631
21ARAF1.60827344
22CDK51.59145153
23TYRO31.57387117
24TESK11.45627512
25MAP2K41.45121147
26UHMK11.42677810
27MAP3K21.40237185
28CASK1.38483992
29KSR11.38254009
30SGK2231.31851652
31SGK4941.31851652
32PNCK1.29354329
33CAMKK21.28977325
34RIPK41.22389117
35STK381.17658083
36CAMK2B1.13007651
37GRK51.12013110
38PRKCG1.11241641
39DAPK11.11074675
40MAP3K121.10676962
41MAP3K131.09973138
42WNK41.09457208
43PINK11.07835943
44MAPK131.05971162
45WNK11.05510760
46TAOK11.05224140
47FES1.02310055
48CDK151.02197257
49CDK181.01206427
50CDK141.00730192
51CAMK2A0.96437523
52STK110.95479709
53PHKG10.95398131
54PHKG20.95398131
55MAP3K110.94807073
56NEK60.94246754
57PLK20.92202664
58CDK11A0.89668204
59PKN10.87208696
60PRKCH0.87127236
61BRSK10.86322937
62PAK30.85773678
63BCR0.84799333
64CSNK1G20.84629437
65CAMK10.83789370
66MARK20.82163874
67FGFR20.79438034
68SIK20.78763397
69CAMK2G0.78109886
70TRIB30.76298011
71CAMK2D0.75512803
72RAF10.75425383
73RET0.73142654
74ALK0.72772604
75MAPKAPK50.70091305
76ICK0.68525901
77WNK30.64198363
78LMTK20.63608118
79SGK10.63480719
80ROCK20.61586827
81EPHA20.60223526
82DYRK1A0.59590333
83LIMK10.57779301
84SGK30.57702656
85SGK20.57677622
86MAP3K10.57392591
87PTK2B0.56833915
88* PDPK10.55523009
89FGR0.55354265
90DAPK30.54419042
91FYN0.52081414
92PRKG20.50956973
93CSNK1G30.50250834
94MAPK120.49904856
95PRKCE0.48679411
96* PDK10.47505312
97RPS6KA30.47477132
98CAMK1G0.44946025
99BMPR20.44385817
100CSNK1A1L0.43728771
101MAPK100.43558780
102TNK20.43299467
103MAP2K10.42796988
104EEF2K0.42563876
105* PRKCZ0.41288020
106CDC42BPA0.39738047
107MST1R0.38849615
108BRAF0.38291436
109CAMK40.37491406
110LATS20.37039556
111MAPK80.35005050
112NME10.34650867
113ERBB20.33409846
114DYRK1B0.33196924
115IRAK20.32342304
116RPS6KA20.30902080
117SRC0.29792764

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.35314135
2Nicotine addiction_Homo sapiens_hsa050333.28711042
3Olfactory transduction_Homo sapiens_hsa047402.81004938
4GABAergic synapse_Homo sapiens_hsa047272.74378348
5Glutamatergic synapse_Homo sapiens_hsa047242.59290260
6Circadian entrainment_Homo sapiens_hsa047132.54476837
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.53043209
8Morphine addiction_Homo sapiens_hsa050322.48264885
9Long-term potentiation_Homo sapiens_hsa047202.41858837
10Amphetamine addiction_Homo sapiens_hsa050312.28451152
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.22365295
12Dopaminergic synapse_Homo sapiens_hsa047282.10623102
13Salivary secretion_Homo sapiens_hsa049702.08247525
14Nitrogen metabolism_Homo sapiens_hsa009101.97385919
15Cholinergic synapse_Homo sapiens_hsa047251.89432824
16Gastric acid secretion_Homo sapiens_hsa049711.86656049
17Insulin secretion_Homo sapiens_hsa049111.84902375
18Long-term depression_Homo sapiens_hsa047301.70255719
19Cocaine addiction_Homo sapiens_hsa050301.69398795
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.66181427
21Taste transduction_Homo sapiens_hsa047421.63856828
22Serotonergic synapse_Homo sapiens_hsa047261.57146132
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55775544
24Collecting duct acid secretion_Homo sapiens_hsa049661.48703059
25Oxytocin signaling pathway_Homo sapiens_hsa049211.47818097
26Renin secretion_Homo sapiens_hsa049241.47685250
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.47080186
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.44371126
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.38689873
30Calcium signaling pathway_Homo sapiens_hsa040201.37162053
31Gap junction_Homo sapiens_hsa045401.33874204
32GnRH signaling pathway_Homo sapiens_hsa049121.30462642
33Phototransduction_Homo sapiens_hsa047441.22277109
34Axon guidance_Homo sapiens_hsa043601.21592992
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21457183
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18224781
37cAMP signaling pathway_Homo sapiens_hsa040241.16702788
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14246446
39ErbB signaling pathway_Homo sapiens_hsa040121.01392716
40Fatty acid biosynthesis_Homo sapiens_hsa000611.01342040
41Histidine metabolism_Homo sapiens_hsa003400.97127869
42Estrogen signaling pathway_Homo sapiens_hsa049150.96255653
43Arginine and proline metabolism_Homo sapiens_hsa003300.94734963
44Vibrio cholerae infection_Homo sapiens_hsa051100.94556230
45Phospholipase D signaling pathway_Homo sapiens_hsa040720.93524858
46Cardiac muscle contraction_Homo sapiens_hsa042600.92247311
47Pancreatic secretion_Homo sapiens_hsa049720.91661146
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.90791959
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90323806
50Glioma_Homo sapiens_hsa052140.89184407
51Butanoate metabolism_Homo sapiens_hsa006500.88053599
52Melanogenesis_Homo sapiens_hsa049160.86746732
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86053648
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85937952
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85273516
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84370418
57Bile secretion_Homo sapiens_hsa049760.82025347
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80128377
59* Type II diabetes mellitus_Homo sapiens_hsa049300.78711512
60Dorso-ventral axis formation_Homo sapiens_hsa043200.78103282
61Thyroid hormone synthesis_Homo sapiens_hsa049180.76669452
62Choline metabolism in cancer_Homo sapiens_hsa052310.76610199
63Oocyte meiosis_Homo sapiens_hsa041140.72360753
64Phenylalanine metabolism_Homo sapiens_hsa003600.71876232
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.71703875
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69867581
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67109377
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66046439
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64575580
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64447333
71* Endocytosis_Homo sapiens_hsa041440.62077199
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60696836
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.56365653
74MAPK signaling pathway_Homo sapiens_hsa040100.55838335
75Ras signaling pathway_Homo sapiens_hsa040140.54249360
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54129533
77Renal cell carcinoma_Homo sapiens_hsa052110.53291027
78Arginine biosynthesis_Homo sapiens_hsa002200.52617141
79Inositol phosphate metabolism_Homo sapiens_hsa005620.52592319
80* Sphingolipid signaling pathway_Homo sapiens_hsa040710.50613739
81VEGF signaling pathway_Homo sapiens_hsa043700.50113555
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48771339
83Alcoholism_Homo sapiens_hsa050340.47440992
84AMPK signaling pathway_Homo sapiens_hsa041520.46366146
85Ether lipid metabolism_Homo sapiens_hsa005650.45308726
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44493150
87Dilated cardiomyopathy_Homo sapiens_hsa054140.43863265
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42708782
89Mineral absorption_Homo sapiens_hsa049780.42385217
90Alzheimers disease_Homo sapiens_hsa050100.41663535
91Prion diseases_Homo sapiens_hsa050200.41443004
92* Rap1 signaling pathway_Homo sapiens_hsa040150.39980260
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38695783
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37986057
95Ovarian steroidogenesis_Homo sapiens_hsa049130.37218066
96Vitamin B6 metabolism_Homo sapiens_hsa007500.36314635
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.36016916
98Wnt signaling pathway_Homo sapiens_hsa043100.35900365
99* Tight junction_Homo sapiens_hsa045300.35823756
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34845540
101* Insulin signaling pathway_Homo sapiens_hsa049100.34142884
102beta-Alanine metabolism_Homo sapiens_hsa004100.34047568
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33121764
104Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31832008
105Glucagon signaling pathway_Homo sapiens_hsa049220.30775345
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30185000
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29959750
108Non-small cell lung cancer_Homo sapiens_hsa052230.29203849
109Biosynthesis of amino acids_Homo sapiens_hsa012300.28988836
110mTOR signaling pathway_Homo sapiens_hsa041500.28826915
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28401550
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27518959
113Circadian rhythm_Homo sapiens_hsa047100.27422507
114Glycerolipid metabolism_Homo sapiens_hsa005610.27408912
115Endometrial cancer_Homo sapiens_hsa052130.24847187
116Protein digestion and absorption_Homo sapiens_hsa049740.24742586

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »