PRKD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.83510336
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.73049180
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.73049180
4antigen processing and presentation of endogenous antigen (GO:0019883)6.42011732
5regulation of gamma-delta T cell differentiation (GO:0045586)5.77321131
6positive thymic T cell selection (GO:0045059)5.30096460
7regulation of gamma-delta T cell activation (GO:0046643)5.29996797
8negative T cell selection (GO:0043383)5.13001391
9negative thymic T cell selection (GO:0045060)4.91874477
10positive regulation by symbiont of host defense response (GO:0052509)4.87003645
11modulation by symbiont of host defense response (GO:0052031)4.87003645
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.87003645
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.87003645
14positive regulation by organism of defense response of other organism involved in symbiotic interact4.87003645
15modulation by symbiont of host immune response (GO:0052553)4.87003645
16positive T cell selection (GO:0043368)4.82284384
17response to interleukin-15 (GO:0070672)4.74502441
18* positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.65187545
19thymic T cell selection (GO:0045061)4.64089189
20detection of bacterium (GO:0016045)4.61354560
21T cell selection (GO:0045058)4.55610977
22detection of other organism (GO:0098543)4.53183747
23regulation of B cell receptor signaling pathway (GO:0050855)4.38299644
24B cell receptor signaling pathway (GO:0050853)4.31892063
25interferon-gamma production (GO:0032609)4.29448107
26cellular response to interleukin-15 (GO:0071350)4.26745922
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.21216726
28negative regulation of cell killing (GO:0031342)4.21216726
29T cell migration (GO:0072678)4.20233462
30leukocyte aggregation (GO:0070486)4.13531195
31regulation of B cell differentiation (GO:0045577)4.13091039
32positive regulation of B cell differentiation (GO:0045579)4.00454744
33macrophage activation involved in immune response (GO:0002281)3.99107439
34positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.97125201
35negative regulation of lymphocyte mediated immunity (GO:0002707)3.92013328
36regulation of interferon-beta biosynthetic process (GO:0045357)3.86649620
37regulation of interleukin-12 biosynthetic process (GO:0045075)3.85726258
38ribosomal small subunit assembly (GO:0000028)3.79835309
39T cell homeostasis (GO:0043029)3.75033527
40* antigen receptor-mediated signaling pathway (GO:0050851)3.74588565
41regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.68304065
42* T cell receptor signaling pathway (GO:0050852)3.67182432
43immunoglobulin mediated immune response (GO:0016064)3.65736788
44neutrophil activation involved in immune response (GO:0002283)3.65677635
45regulation of T cell tolerance induction (GO:0002664)3.62036450
46regulation of regulatory T cell differentiation (GO:0045589)3.56574100
47viral transcription (GO:0019083)3.55580060
48negative regulation of leukocyte mediated immunity (GO:0002704)3.54165595
49detection of external biotic stimulus (GO:0098581)3.53809301
50tolerance induction (GO:0002507)3.50130922
51T cell costimulation (GO:0031295)3.47481789
52lymphocyte costimulation (GO:0031294)3.46367635
53NIK/NF-kappaB signaling (GO:0038061)3.45752865
54antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.43626205
55antigen processing and presentation via MHC class Ib (GO:0002475)3.43052720
56negative regulation of T cell mediated immunity (GO:0002710)3.41908446
57definitive hemopoiesis (GO:0060216)3.41222052
58lymphocyte homeostasis (GO:0002260)3.38853262
59regulation of isotype switching to IgG isotypes (GO:0048302)3.36770140
60response to peptidoglycan (GO:0032494)3.33130291
61regulation of alpha-beta T cell proliferation (GO:0046640)3.32832156
62neutrophil activation (GO:0042119)3.32400053
63germinal center formation (GO:0002467)3.32148155
64negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.30883402
65negative regulation of phagocytosis (GO:0050765)3.29276648
66translational termination (GO:0006415)3.28290700
67positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.28093805
68response to muramyl dipeptide (GO:0032495)3.26248570
69positive regulation of tolerance induction (GO:0002645)3.26098583
70regulation of natural killer cell mediated immunity (GO:0002715)3.25042096
71regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.25042096
72response to host immune response (GO:0052572)3.24362483
73response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.24362483
74regulation of dendritic cell antigen processing and presentation (GO:0002604)3.24244947
75* regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.23760809
76respiratory burst (GO:0045730)3.22709988
77negative regulation of interleukin-12 production (GO:0032695)3.22085301
78lymph node development (GO:0048535)3.20177691
79mast cell activation (GO:0045576)3.19326394
80megakaryocyte development (GO:0035855)3.16100636
81cellular response to zinc ion (GO:0071294)3.14206626
82positive regulation of isotype switching (GO:0045830)3.13793626
83JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.11853892
84response to host (GO:0075136)3.11638627
85response to host defenses (GO:0052200)3.11638627
86response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.11638627
87negative regulation of erythrocyte differentiation (GO:0045647)3.11620308
88negative regulation of innate immune response (GO:0045824)3.10908056
89positive regulation of T cell mediated cytotoxicity (GO:0001916)3.10829258
90cellular extravasation (GO:0045123)3.10345618
91leukocyte migration involved in inflammatory response (GO:0002523)3.09885828
92regulation of T cell mediated cytotoxicity (GO:0001914)3.08390009
93* positive regulation of interleukin-2 production (GO:0032743)3.06313691
94detection of biotic stimulus (GO:0009595)3.05123669
95leukocyte homeostasis (GO:0001776)3.04898423
96positive regulation of granulocyte differentiation (GO:0030854)3.04698961
97regulation of response to interferon-gamma (GO:0060330)3.02040747
98granulocyte activation (GO:0036230)3.00765962
99T cell differentiation (GO:0030217)3.00677500
100regulation of type I interferon-mediated signaling pathway (GO:0060338)2.99925798
101regulation of interleukin-2 biosynthetic process (GO:0045076)2.99309066
102mast cell activation involved in immune response (GO:0002279)2.98944903
103mast cell degranulation (GO:0043303)2.98944903
104regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.98499368
105regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.95878132
106hepatocyte apoptotic process (GO:0097284)2.95239064
107negative regulation of alpha-beta T cell activation (GO:0046636)2.93698014
108regulation of tolerance induction (GO:0002643)2.92465638
109response to type I interferon (GO:0034340)2.92328990
110myeloid cell activation involved in immune response (GO:0002275)2.92035548
111mature B cell differentiation (GO:0002335)2.90977379
112leukocyte cell-cell adhesion (GO:0007159)2.89573494
113myeloid dendritic cell activation (GO:0001773)2.89224992
114regulation of antigen processing and presentation (GO:0002577)2.88239968
115negative regulation of interleukin-6 production (GO:0032715)2.86887983
116* regulation of T cell receptor signaling pathway (GO:0050856)2.86728296
117positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.86622074
118alpha-beta T cell activation (GO:0046631)2.86455225
119response to protozoan (GO:0001562)2.85567453
120regulation of mast cell degranulation (GO:0043304)2.84929657
121positive regulation of interferon-alpha production (GO:0032727)2.83378521
122type I interferon signaling pathway (GO:0060337)2.81672438
123cellular response to type I interferon (GO:0071357)2.81672438
124V(D)J recombination (GO:0033151)2.81525481
125* immune response-activating cell surface receptor signaling pathway (GO:0002429)2.79869544
126positive regulation of alpha-beta T cell proliferation (GO:0046641)2.79516360
127positive regulation of immunoglobulin production (GO:0002639)2.79442645
128positive regulation of Cdc42 GTPase activity (GO:0043089)2.78846532
129positive regulation of humoral immune response (GO:0002922)2.78148158
130B cell mediated immunity (GO:0019724)2.77772178
131defense response to protozoan (GO:0042832)2.77448376
132interferon-gamma secretion (GO:0072643)2.77361587
133Peyers patch development (GO:0048541)2.77235270
134mucosal-associated lymphoid tissue development (GO:0048537)2.77235270
135natural killer cell differentiation (GO:0001779)2.76809658
136B cell homeostasis (GO:0001782)2.75844355
137translational elongation (GO:0006414)2.75836053
138ribosomal small subunit biogenesis (GO:0042274)2.75159552
139positive regulation of antigen processing and presentation (GO:0002579)2.74262473
140negative regulation of T-helper cell differentiation (GO:0045623)2.72340027
141negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.72340027
142positive regulation of DNA recombination (GO:0045911)2.71387713
143activated T cell proliferation (GO:0050798)2.70125607
144natural killer cell activation (GO:0030101)2.70039815
145nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.68938913
146positive regulation of B cell activation (GO:0050871)2.67186526
147T cell proliferation (GO:0042098)2.65547467
148angiogenesis involved in wound healing (GO:0060055)2.65322335
149interferon-gamma-mediated signaling pathway (GO:0060333)2.64751458

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.41490935
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.00392341
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.28221695
4MYC_22102868_ChIP-Seq_BL_Human4.06395246
5E2F7_22180533_ChIP-Seq_HELA_Human3.80880505
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.59775653
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.34475871
8VDR_21846776_ChIP-Seq_THP-1_Human3.11961185
9FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.08708079
10SCL_19346495_ChIP-Seq_HPC-7_Human3.04135058
11* RUNX_20019798_ChIP-Seq_JUKART_Human3.01855392
12* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.94983283
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.83960777
14MAF_26560356_Chip-Seq_TH1_Human2.83294034
15* MYB_26560356_Chip-Seq_TH2_Human2.81012126
16* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.73964329
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.66290274
18* IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.61833236
19* UTX_26944678_Chip-Seq_JUKART_Human2.60761501
20* MYB_26560356_Chip-Seq_TH1_Human2.53676868
21* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.42461488
22TCF7_22412390_ChIP-Seq_EML_Mouse2.39789552
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.31391587
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.28469347
25* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.27211792
26IRF8_21731497_ChIP-ChIP_J774_Mouse2.26291826
27* VDR_24763502_ChIP-Seq_THP-1_Human2.15547156
28* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.15185337
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.09208773
30MYB_21317192_ChIP-Seq_ERMYB_Mouse2.07603365
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02361667
32* RUNX1_22412390_ChIP-Seq_EML_Mouse2.02273831
33NOTCH1_21737748_ChIP-Seq_TLL_Human2.02086092
34* SPI1_23547873_ChIP-Seq_NB4_Human2.01386407
35KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.96118418
36* IRF8_27001747_Chip-Seq_BMDM_Mouse1.94068640
37MAF_26560356_Chip-Seq_TH2_Human1.92152557
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.83469544
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.81532381
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.80302499
41* KDM2B_26808549_Chip-Seq_DND41_Human1.79056167
42FOXM1_23109430_ChIP-Seq_U2OS_Human1.78140441
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.76274751
44* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.75709189
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.75527351
46* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.73194673
47CIITA_25753668_ChIP-Seq_RAJI_Human1.71771928
48* ELK3_25401928_ChIP-Seq_HUVEC_Human1.68845113
49GATA3_27048872_Chip-Seq_THYMUS_Human1.66358324
50* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.64761163
51SPI1_23127762_ChIP-Seq_K562_Human1.63349143
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.52342650
53TP63_17297297_ChIP-ChIP_HaCaT_Human1.49381574
54* RACK7_27058665_Chip-Seq_MCF-7_Human1.48709554
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.45666452
56RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.44261713
57BCOR_27268052_Chip-Seq_Bcells_Human1.43801283
58P68_20966046_ChIP-Seq_HELA_Human1.40437973
59* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39240999
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37107786
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35146715
62NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32772648
63TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32183427
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32068407
65SA1_27219007_Chip-Seq_ERYTHROID_Human1.32005230
66ELF1_20517297_ChIP-Seq_JURKAT_Human1.31864055
67GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30044047
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29979608
69EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.24800686
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23830657
71PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22437600
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21918132
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17803821
74GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14541383
75PU_27001747_Chip-Seq_BMDM_Mouse1.14442298
76* KDM2B_26808549_Chip-Seq_JURKAT_Human1.14127193
77GATA1_22025678_ChIP-Seq_K562_Human1.12496293
78KDM2B_26808549_Chip-Seq_K562_Human1.11564348
79ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11373803
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11333277
81GATA1_19941827_ChIP-Seq_MEL_Mouse1.10117094
82* SMC4_20622854_ChIP-Seq_HELA_Human1.09710685
83NCOR1_26117541_ChIP-Seq_K562_Human1.09329498
84GATA2_21666600_ChIP-Seq_HMVEC_Human1.09129730
85SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.08124928
86* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07196827
87E2F1_20622854_ChIP-Seq_HELA_Human1.06562008
88TP63_19390658_ChIP-ChIP_HaCaT_Human1.06488465
89CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05652067
90CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05218149
91E2F4_17652178_ChIP-ChIP_JURKAT_Human1.02982918
92EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02332991
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.00978537
94CTCF_21964334_ChIP-Seq_BJAB-B_Human1.00595411
95PHF8_20622854_ChIP-Seq_HELA_Human0.99900624
96FOXP3_21729870_ChIP-Seq_TREG_Human0.98048294
97TET1_21451524_ChIP-Seq_MESCs_Mouse0.97453104
98CTCF_26484167_Chip-Seq_Bcells_Mouse0.97245256
99SA1_27219007_Chip-Seq_Bcells_Human0.96458071
100GATA3_26560356_Chip-Seq_TH2_Human0.94505832
101PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94355555
102PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93905305
103KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93730099
104SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.93678301
105* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93443116
106EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91042279
107SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.90845354
108CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90051905
109NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89853345
110VDR_24787735_ChIP-Seq_THP-1_Human0.89726963
111CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89650285
112IKZF1_21737484_ChIP-ChIP_HCT116_Human0.89568100
113GATA1_19941826_ChIP-Seq_K562_Human0.84527757
114LXR_22292898_ChIP-Seq_THP-1_Human0.84387209
115STAT6_21828071_ChIP-Seq_BEAS2B_Human0.83576174
116SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81323478
117THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.80226944
118GATA2_19941826_ChIP-Seq_K562_Human0.79459561
119SMAD_19615063_ChIP-ChIP_OVARY_Human0.79129518
120* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.78970122
121VDR_23849224_ChIP-Seq_CD4+_Human0.78891221
122RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76182311
123* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72973653
124DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.71922040
125BCL6_27268052_Chip-Seq_Bcells_Human0.71750026
126CTCF_27219007_Chip-Seq_ERYTHROID_Human0.70936296
127STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.70254039

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.00346927
2MP0001835_abnormal_antigen_presentation3.80693411
3MP0000685_abnormal_immune_system3.48729649
4* MP0001800_abnormal_humoral_immune3.33265348
5MP0005671_abnormal_response_to3.28366325
6MP0001790_abnormal_immune_system3.26466625
7MP0005387_immune_system_phenotype3.26466625
8MP0002396_abnormal_hematopoietic_system2.91734444
9MP0002398_abnormal_bone_marrow2.70194244
10* MP0002452_abnormal_antigen_presenting2.69443677
11* MP0002420_abnormal_adaptive_immunity2.64329354
12MP0005000_abnormal_immune_tolerance2.63482273
13* MP0002723_abnormal_immune_serum2.59990427
14* MP0001819_abnormal_immune_cell2.59889765
15MP0009785_altered_susceptibility_to2.48287343
16MP0000716_abnormal_immune_system2.36446036
17MP0002166_altered_tumor_susceptibility2.35581156
18MP0004808_abnormal_hematopoietic_stem2.35167752
19MP0001873_stomach_inflammation2.32821238
20MP0003724_increased_susceptibility_to2.31060311
21MP0005025_abnormal_response_to2.27477923
22MP0010155_abnormal_intestine_physiology2.22173038
23MP0000689_abnormal_spleen_morphology2.20197467
24MP0003436_decreased_susceptibility_to2.19640047
25MP0000703_abnormal_thymus_morphology2.19210336
26MP0002722_abnormal_immune_system2.18361263
27MP0003303_peritoneal_inflammation2.16903107
28MP0003300_gastrointestinal_ulcer2.16485717
29MP0002405_respiratory_system_inflammati2.15531565
30MP0009333_abnormal_splenocyte_physiolog2.02984446
31MP0002429_abnormal_blood_cell2.00414113
32MP0009278_abnormal_bone_marrow1.97549386
33MP0005464_abnormal_platelet_physiology1.91545553
34MP0005451_abnormal_body_composition1.89556314
35MP0002148_abnormal_hypersensitivity_rea1.86751319
36MP0008260_abnormal_autophagy1.86066565
37MP0004510_myositis1.84111808
38MP0003866_abnormal_defecation1.82408157
39MP0000465_gastrointestinal_hemorrhage1.82392470
40MP0002419_abnormal_innate_immunity1.82334720
41MP0002006_tumorigenesis1.82185858
42MP0004947_skin_inflammation1.72722743
43MP0001853_heart_inflammation1.62891959
44MP0005397_hematopoietic_system_phenotyp1.61499749
45MP0001545_abnormal_hematopoietic_system1.61499749
46MP0001845_abnormal_inflammatory_respons1.59186659
47MP0001879_abnormal_lymphatic_vessel1.51482460
48MP0002933_joint_inflammation1.49463297
49MP0000490_abnormal_crypts_of1.45670455
50MP0003183_abnormal_peptide_metabolism1.45372144
51MP0006082_CNS_inflammation1.44222854
52MP0003172_abnormal_lysosome_physiology1.39085415
53MP0002277_abnormal_respiratory_mucosa1.33468513
54MP0002132_abnormal_respiratory_system1.25910374
55MP0005174_abnormal_tail_pigmentation1.22204168
56MP0005310_abnormal_salivary_gland1.20829218
57MP0003828_pulmonary_edema1.18910721
58MP0010368_abnormal_lymphatic_system1.18302433
59MP0006054_spinal_hemorrhage1.16067701
60MP0000858_altered_metastatic_potential1.13732354
61MP0002019_abnormal_tumor_incidence1.10930629
62MP0000678_abnormal_parathyroid_gland1.09146923
63MP0001851_eye_inflammation1.08718780
64MP0005075_abnormal_melanosome_morpholog1.07411442
65MP0001533_abnormal_skeleton_physiology1.01506396
66MP0008469_abnormal_protein_level0.97982964
67MP0004264_abnormal_extraembryonic_tissu0.92520877
68MP0010352_gastrointestinal_tract_polyps0.91829767
69MP0002138_abnormal_hepatobiliary_system0.91414457
70MP0003448_altered_tumor_morphology0.91189911
71MP0004883_abnormal_blood_vessel0.88197113
72MP0008961_abnormal_basal_metabolism0.86094710
73MP0003566_abnormal_cell_adhesion0.85493246
74MP0003077_abnormal_cell_cycle0.84484146
75MP0005023_abnormal_wound_healing0.83233897
76MP0003279_aneurysm0.80621293
77MP0005390_skeleton_phenotype0.78409514
78MP0003943_abnormal_hepatobiliary_system0.78302999
79MP0004381_abnormal_hair_follicle0.75330049
80MP0003705_abnormal_hypodermis_morpholog0.74933118
81MP0010094_abnormal_chromosome_stability0.74463289
82MP0002095_abnormal_skin_pigmentation0.73913787
83MP0001849_ear_inflammation0.71936328
84MP0008057_abnormal_DNA_replication0.70746927
85MP0004858_abnormal_nervous_system0.70164292
86MP0002653_abnormal_ependyma_morphology0.70007740
87MP0000249_abnormal_blood_vessel0.69967621
88MP0009840_abnormal_foam_cell0.69558201
89MP0001986_abnormal_taste_sensitivity0.69152690
90MP0000477_abnormal_intestine_morphology0.68265839
91MP0008007_abnormal_cellular_replicative0.67856294
92MP0000767_abnormal_smooth_muscle0.67743065
93MP0005381_digestive/alimentary_phenotyp0.67340645
94MP0002796_impaired_skin_barrier0.66789430
95MP0009764_decreased_sensitivity_to0.66693138
96MP0002998_abnormal_bone_remodeling0.66131798
97MP0003091_abnormal_cell_migration0.65773466
98MP0005164_abnormal_response_to0.65149948
99MP0001663_abnormal_digestive_system0.64772805
100MP0001348_abnormal_lacrimal_gland0.64264080
101MP0005058_abnormal_lysosome_morphology0.64240455
102MP0002928_abnormal_bile_duct0.64198019
103MP0002009_preneoplasia0.63281112
104MP0003693_abnormal_embryo_hatching0.63149614
105MP0002254_reproductive_system_inflammat0.62483912
106MP0009763_increased_sensitivity_to0.61886121
107MP0005377_hearing/vestibular/ear_phenot0.60666783
108MP0003878_abnormal_ear_physiology0.60666783
109MP0000470_abnormal_stomach_morphology0.59964524
110MP0002136_abnormal_kidney_physiology0.58851222
111MP0005166_decreased_susceptibility_to0.58356242
112MP0005409_darkened_coat_color0.57918089
113MP0003045_fibrosis0.56435973
114MP0004185_abnormal_adipocyte_glucose0.56259552
115MP0000343_altered_response_to0.56110483
116MP0000313_abnormal_cell_death0.55801495
117MP0005076_abnormal_cell_differentiation0.55669964
118MP0010630_abnormal_cardiac_muscle0.53435203
119MP0003191_abnormal_cellular_cholesterol0.51925161
120MP0000015_abnormal_ear_pigmentation0.51898579
121MP0009931_abnormal_skin_appearance0.50894740
122MP0008058_abnormal_DNA_repair0.50827514
123MP0003453_abnormal_keratinocyte_physiol0.49376215
124MP0001191_abnormal_skin_condition0.49280889
125MP0005670_abnormal_white_adipose0.48770822
126MP0009765_abnormal_xenobiotic_induced0.47292382
127MP0002128_abnormal_blood_circulation0.46874220

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)5.33397651
2Panhypogammaglobulinemia (HP:0003139)5.23690138
3Recurrent bronchitis (HP:0002837)4.95946103
4T lymphocytopenia (HP:0005403)4.92532318
5Chronic otitis media (HP:0000389)4.83729480
6Recurrent viral infections (HP:0004429)4.76392185
7IgM deficiency (HP:0002850)4.73927893
8Abnormality of T cell number (HP:0011839)4.69246563
9Abnormal delayed hypersensitivity skin test (HP:0002963)4.58285297
10Recurrent fungal infections (HP:0002841)4.26643132
11Abnormality of macrophages (HP:0004311)4.25880852
12Abnormality of B cell number (HP:0010975)4.15879430
13B lymphocytopenia (HP:0010976)4.15879430
14Abnormality of T cells (HP:0002843)4.06862212
15Abnormality of the fingertips (HP:0001211)3.99700094
16Cellulitis (HP:0100658)3.96448092
17Inflammation of the large intestine (HP:0002037)3.95044974
18Abnormality of the nasal mucosa (HP:0000433)3.92426575
19Nasal polyposis (HP:0100582)3.91339926
20Gastrointestinal infarctions (HP:0005244)3.89843279
21Gastrointestinal inflammation (HP:0004386)3.87042859
22Meningitis (HP:0001287)3.81215166
23Recurrent gram-negative bacterial infections (HP:0005420)3.81099288
24Colitis (HP:0002583)3.71825916
25Severe combined immunodeficiency (HP:0004430)3.65395806
26Spontaneous hematomas (HP:0007420)3.61852988
27Thyroiditis (HP:0100646)3.60950006
28Recurrent cutaneous fungal infections (HP:0011370)3.60719825
29Chronic mucocutaneous candidiasis (HP:0002728)3.60719825
30Elevated erythrocyte sedimentation rate (HP:0003565)3.58126553
31Verrucae (HP:0200043)3.58106397
32Papilloma (HP:0012740)3.58106397
33Lymphopenia (HP:0001888)3.46379209
34Gastrointestinal stroma tumor (HP:0100723)3.45859124
35Combined immunodeficiency (HP:0005387)3.43326951
36Prolonged bleeding time (HP:0003010)3.38990532
37Abnormality of cells of the lymphoid lineage (HP:0012140)3.32612044
38Hypochromic anemia (HP:0001931)3.28276106
39Chronic sinusitis (HP:0011109)3.26388573
40Recurrent sinusitis (HP:0011108)3.18019089
41Eczematoid dermatitis (HP:0000976)3.17645870
42Gingivitis (HP:0000230)3.16923507
43Abnormality of T cell physiology (HP:0011840)3.16382189
44IgG deficiency (HP:0004315)3.15778364
45Recurrent abscess formation (HP:0002722)3.07063291
46Eosinophilia (HP:0001880)3.05812443
47Myositis (HP:0100614)3.05195932
48Urticaria (HP:0001025)3.03521426
49Pustule (HP:0200039)3.01414670
50Thrombocytosis (HP:0001894)2.99546565
51Keratoconjunctivitis sicca (HP:0001097)2.97039729
52Vasculitis (HP:0002633)2.94556141
53Autoimmune thrombocytopenia (HP:0001973)2.89389100
54Emphysema (HP:0002097)2.87886896
55Abnormality of eosinophils (HP:0001879)2.87502890
56Bronchitis (HP:0012387)2.85291214
57Hypochromic microcytic anemia (HP:0004840)2.84878495
58Increased IgE level (HP:0003212)2.81230643
59Granulocytopenia (HP:0001913)2.78168642
60Stomatitis (HP:0010280)2.74146935
61Keratoconjunctivitis (HP:0001096)2.72986338
62Increased IgM level (HP:0003496)2.65808607
63Chronic diarrhea (HP:0002028)2.60841755
64IgA deficiency (HP:0002720)2.56152589
65Lymphoma (HP:0002665)2.55074408
66Recurrent skin infections (HP:0001581)2.55061787
67Recurrent bacterial skin infections (HP:0005406)2.51174833
68Leukocytosis (HP:0001974)2.48883043
69Epistaxis (HP:0000421)2.48235669
70Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.46359235
71Encephalitis (HP:0002383)2.44520290
72Petechiae (HP:0000967)2.42965357
73Reticulocytopenia (HP:0001896)2.42096924
74Hypoplasia of the thymus (HP:0000778)2.41890644
75Mediastinal lymphadenopathy (HP:0100721)2.41328489
76Chronic obstructive pulmonary disease (HP:0006510)2.35962536
77Obstructive lung disease (HP:0006536)2.35962536
78Hypergammaglobulinemia (HP:0010702)2.34834027
79Premature loss of primary teeth (HP:0006323)2.33313990
80Basal cell carcinoma (HP:0002671)2.33209593
81Osteomyelitis (HP:0002754)2.29471111
82Sepsis (HP:0100806)2.28558879
83Abnormal platelet volume (HP:0011876)2.26135927
84Autoimmune hemolytic anemia (HP:0001890)2.25641626
85Hemoptysis (HP:0002105)2.24279778
86Pulmonary embolism (HP:0002204)2.23490187
87Impaired platelet aggregation (HP:0003540)2.22918771
88Abnormal platelet function (HP:0011869)2.22918771
89Anorexia (HP:0002039)2.19426986
90Abnormality of the pleura (HP:0002103)2.18312679
91Peritonitis (HP:0002586)2.15996800
92Skin ulcer (HP:0200042)2.15868336
93Chest pain (HP:0100749)2.15400276
94Hypoproteinemia (HP:0003075)2.15183303
95Episodic fever (HP:0001954)2.13202353
96Recurrent otitis media (HP:0000403)2.11167471
97Microcytic anemia (HP:0001935)2.11024789
98Abnormality of the peritoneum (HP:0002585)2.08466180
99Interstitial pulmonary disease (HP:0006530)2.06059993
100Abnormality of cells of the erythroid lineage (HP:0012130)2.04842068
101Poikiloderma (HP:0001029)2.02438095
102Gingival bleeding (HP:0000225)2.00291395
103Recurrent lower respiratory tract infections (HP:0002783)1.99932274
104Increased density of long bones (HP:0006392)1.95402308
105Abnormal number of erythroid precursors (HP:0012131)1.93497652
106Pulmonary infiltrates (HP:0002113)1.93281838
107Malnutrition (HP:0004395)1.92987318
108Skin rash (HP:0000988)1.91112738
109Polygenic inheritance (HP:0010982)1.89570963
110Hematochezia (HP:0002573)1.88958952
111Hemorrhage of the eye (HP:0011885)1.88505559
112Restrictive lung disease (HP:0002091)1.88475853
113Viral hepatitis (HP:0006562)1.88469678
114Hypertensive crisis (HP:0100735)1.86649935
115Arterial thrombosis (HP:0004420)1.86425110
116Recurrent pneumonia (HP:0006532)1.85452618
117Orchitis (HP:0100796)1.85335794
118Obstructive sleep apnea (HP:0002870)1.85176751
119Gangrene (HP:0100758)1.84957240
120Entropion (HP:0000621)1.84543949
121Optic neuritis (HP:0100653)1.84271241
122Retrobulbar optic neuritis (HP:0100654)1.84271241
123Seborrheic dermatitis (HP:0001051)1.83070526
124Segmental peripheral demyelination/remyelination (HP:0003481)1.82901758
125Acne (HP:0001061)1.82581042
126Abnormality of the pericardium (HP:0001697)1.80653793
127Leukopenia (HP:0001882)1.80482126
128Easy fatigability (HP:0003388)1.79505948
129Acute lymphatic leukemia (HP:0006721)1.77692284
130Bronchiectasis (HP:0002110)1.77571384
131Joint swelling (HP:0001386)1.76462443

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.88281317
2TXK3.14049874
3MAP3K102.81526872
4EEF2K2.77348232
5PRPF4B2.69560839
6JAK32.53814169
7STK102.39599012
8ZAP702.31224480
9TYK22.20569561
10BTK2.19592556
11GRK62.17110492
12SMG12.08354609
13IKBKE2.07461161
14ITK2.05401151
15KDR2.00374520
16KIT1.98585944
17BLK1.86232553
18FGFR41.85911071
19TEC1.84449606
20MAP3K141.78198613
21TIE11.75192207
22NLK1.74567531
23TGFBR21.70332510
24SYK1.68188947
25ERN11.63865570
26CSF1R1.58023718
27JAK11.56801649
28MAP2K31.55751449
29LRRK21.54897456
30TBK11.47242916
31LCK1.43199722
32FGFR31.40937661
33IRAK41.40314332
34HCK1.38050290
35PKN21.32829103
36CSK1.31213925
37FLT31.30594825
38RPS6KA41.29490824
39MAP3K131.27435708
40CLK11.24778504
41TGFBR11.23191429
42TRIB31.22816696
43MAP3K111.22595175
44NME21.21877352
45SIK21.21749942
46IKBKB1.21093997
47CDK121.14386888
48PIM11.13711824
49EPHB11.10421177
50CDC42BPA1.06473412
51MAP3K11.05350259
52MARK31.04062987
53TESK21.03098877
54FGR0.98387568
55CHUK0.95805190
56LYN0.95028893
57FES0.92422466
58MAP3K70.88403954
59RPS6KB20.86113245
60TNK20.84671421
61CDK40.84248091
62MAP2K20.83755070
63MST40.83429437
64KSR20.83044090
65IRAK20.80157971
66PTK60.77734032
67IRAK30.77678870
68PRKCQ0.76214465
69STK40.76044662
70CDK90.75910538
71HIPK20.73947583
72TTN0.73608759
73ICK0.68910385
74NEK20.68731212
75PDPK10.68523013
76SIK30.68057726
77JAK20.67844631
78TAOK20.64523792
79EPHA30.63673393
80BRD40.63199868
81PTK2B0.62608490
82TAOK30.61017789
83* PRKD20.59170626
84SIK10.56774165
85YES10.56027192
86BMX0.54840399
87PASK0.54250321
88MAPK120.51608853
89MAPK70.51561618
90STK240.51529827
91STK110.50864055
92MAPK40.48028082
93RPS6KA20.46850212
94MATK0.44872068
95RIPK40.44674516
96MAPK110.44603335
97TRPM70.44006125
98MARK20.43119768
99FYN0.41887564
100DYRK1B0.41636759
101PDGFRB0.41067946
102RPS6KA60.40499449
103CDK60.38664983
104CDK190.38064780
105MAPKAPK20.37612908
106PDK10.37352224
107PIK3CG0.37306986
108STK380.37175645
109MAP3K80.35919562
110PRKG20.35089966
111CAMKK10.34727996
112ALK0.33779864
113TAOK10.33751255
114DMPK0.33713425
115IRAK10.33475766
116MAP3K60.33012940
117RIPK10.32668490
118ABL10.32266419
119MAPK30.31861315
120MELK0.30861218
121RPS6KC10.30116643
122RPS6KL10.30116643
123RPS6KA50.28747560
124SGK30.28482297
125MAP3K30.27731837
126GRK10.25000346
127CAMK1D0.23686871
128MAP2K60.23629840

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.31198609
2B cell receptor signaling pathway_Homo sapiens_hsa046623.02743841
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.62976700
4T cell receptor signaling pathway_Homo sapiens_hsa046602.61068570
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.55942237
6Hematopoietic cell lineage_Homo sapiens_hsa046402.36395841
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.36082632
8Measles_Homo sapiens_hsa051622.35041688
9Leishmaniasis_Homo sapiens_hsa051402.10901706
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.08909131
11Osteoclast differentiation_Homo sapiens_hsa043802.07792363
12Antigen processing and presentation_Homo sapiens_hsa046121.97971307
13Ribosome_Homo sapiens_hsa030101.91723451
14Jak-STAT signaling pathway_Homo sapiens_hsa046301.78994111
15Acute myeloid leukemia_Homo sapiens_hsa052211.74634227
16Type I diabetes mellitus_Homo sapiens_hsa049401.68674153
17Herpes simplex infection_Homo sapiens_hsa051681.68383652
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.61224516
19Leukocyte transendothelial migration_Homo sapiens_hsa046701.58204766
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.53707190
21Allograft rejection_Homo sapiens_hsa053301.52901255
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.50796564
23Toxoplasmosis_Homo sapiens_hsa051451.46684088
24Chronic myeloid leukemia_Homo sapiens_hsa052201.39180255
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.39019623
26Viral myocarditis_Homo sapiens_hsa054161.37938312
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37741594
28Platelet activation_Homo sapiens_hsa046111.36827049
29Hepatitis B_Homo sapiens_hsa051611.31069585
30Chemokine signaling pathway_Homo sapiens_hsa040621.30668676
31Influenza A_Homo sapiens_hsa051641.25465899
32Non-homologous end-joining_Homo sapiens_hsa034501.22098004
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.19971897
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.19744112
35TNF signaling pathway_Homo sapiens_hsa046681.18332025
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16572481
37Graft-versus-host disease_Homo sapiens_hsa053321.15458048
38HTLV-I infection_Homo sapiens_hsa051661.15213806
39DNA replication_Homo sapiens_hsa030301.12677665
40Shigellosis_Homo sapiens_hsa051311.12259205
41Apoptosis_Homo sapiens_hsa042101.11629507
42Base excision repair_Homo sapiens_hsa034101.10926766
43Malaria_Homo sapiens_hsa051441.10217502
44Pancreatic cancer_Homo sapiens_hsa052121.08939378
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.07181465
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01035699
47Notch signaling pathway_Homo sapiens_hsa043300.99864697
48Small cell lung cancer_Homo sapiens_hsa052220.98259119
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97406058
50Prolactin signaling pathway_Homo sapiens_hsa049170.97078527
51Epstein-Barr virus infection_Homo sapiens_hsa051690.94347647
52Non-small cell lung cancer_Homo sapiens_hsa052230.91381116
53Other glycan degradation_Homo sapiens_hsa005110.91248152
54Hepatitis C_Homo sapiens_hsa051600.88969792
55Autoimmune thyroid disease_Homo sapiens_hsa053200.88894837
56VEGF signaling pathway_Homo sapiens_hsa043700.83559338
57Spliceosome_Homo sapiens_hsa030400.83166056
58Choline metabolism in cancer_Homo sapiens_hsa052310.82983411
59Mismatch repair_Homo sapiens_hsa034300.81623519
60Colorectal cancer_Homo sapiens_hsa052100.81425014
61Viral carcinogenesis_Homo sapiens_hsa052030.80862861
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80584001
63Tuberculosis_Homo sapiens_hsa051520.80528779
64Legionellosis_Homo sapiens_hsa051340.78722450
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.77031362
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.76193008
67Pertussis_Homo sapiens_hsa051330.75992750
68Phagosome_Homo sapiens_hsa041450.72428081
69p53 signaling pathway_Homo sapiens_hsa041150.70386680
70Endocytosis_Homo sapiens_hsa041440.69931693
71FoxO signaling pathway_Homo sapiens_hsa040680.69797519
72Asthma_Homo sapiens_hsa053100.68045641
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67894101
74Homologous recombination_Homo sapiens_hsa034400.65937790
75Caffeine metabolism_Homo sapiens_hsa002320.65051666
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63227642
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.62674943
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.62547533
79Salmonella infection_Homo sapiens_hsa051320.60720126
80MicroRNAs in cancer_Homo sapiens_hsa052060.59315359
81Insulin resistance_Homo sapiens_hsa049310.59220075
82Dorso-ventral axis formation_Homo sapiens_hsa043200.58507702
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57520631
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.57306074
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57186995
86GnRH signaling pathway_Homo sapiens_hsa049120.55671894
87ErbB signaling pathway_Homo sapiens_hsa040120.54020762
88Prostate cancer_Homo sapiens_hsa052150.53393449
89Pathways in cancer_Homo sapiens_hsa052000.52449945
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52441920
91Lysine degradation_Homo sapiens_hsa003100.52270843
92Rheumatoid arthritis_Homo sapiens_hsa053230.51069523
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50499869
94Staphylococcus aureus infection_Homo sapiens_hsa051500.50235176
95Fanconi anemia pathway_Homo sapiens_hsa034600.49462020
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48525191
97Endometrial cancer_Homo sapiens_hsa052130.46673488
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46639603
99African trypanosomiasis_Homo sapiens_hsa051430.45712540
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45626784
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45401839
102Bladder cancer_Homo sapiens_hsa052190.45310580
103Insulin signaling pathway_Homo sapiens_hsa049100.45042644
104Proteoglycans in cancer_Homo sapiens_hsa052050.44747781
105MAPK signaling pathway_Homo sapiens_hsa040100.43639505
106HIF-1 signaling pathway_Homo sapiens_hsa040660.43391861
107RNA degradation_Homo sapiens_hsa030180.43124231
108Cell cycle_Homo sapiens_hsa041100.43022673
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42868207
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41471085
111Focal adhesion_Homo sapiens_hsa045100.41417133
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39282384
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38912127
114Thyroid cancer_Homo sapiens_hsa052160.38738149
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37711145
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36506727
117Type II diabetes mellitus_Homo sapiens_hsa049300.36192410
118* Rap1 signaling pathway_Homo sapiens_hsa040150.35965917
119Renal cell carcinoma_Homo sapiens_hsa052110.35685826
120Regulation of autophagy_Homo sapiens_hsa041400.35214843
121Adherens junction_Homo sapiens_hsa045200.33276953
122Inositol phosphate metabolism_Homo sapiens_hsa005620.32835230
123mRNA surveillance pathway_Homo sapiens_hsa030150.32391523
124mTOR signaling pathway_Homo sapiens_hsa041500.31699911

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