PRKD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to calcium-regulated kinases. Catalytic activity of this enzyme promotes its nuclear localization. This protein has been implicated in a variety of functions including negative regulation of human airway epithelial barrier formation, growth regulation of breast and prostate cancer cells, and vesicle trafficking. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gonadal mesoderm development (GO:0007506)8.27812702
2L-phenylalanine catabolic process (GO:0006559)7.29626073
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.29626073
4nuclear pore complex assembly (GO:0051292)7.26848552
5L-phenylalanine metabolic process (GO:0006558)6.83270308
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.83270308
7mitotic sister chromatid cohesion (GO:0007064)6.62941799
8aromatic amino acid family catabolic process (GO:0009074)6.56334457
9nuclear pore organization (GO:0006999)6.54307612
10indole-containing compound catabolic process (GO:0042436)5.90819769
11indolalkylamine catabolic process (GO:0046218)5.90819769
12tryptophan catabolic process (GO:0006569)5.90819769
13bile acid biosynthetic process (GO:0006699)5.84484744
14glyoxylate metabolic process (GO:0046487)5.73908941
15kynurenine metabolic process (GO:0070189)5.69510988
16alpha-linolenic acid metabolic process (GO:0036109)5.64975439
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.58574131
18tryptophan metabolic process (GO:0006568)5.56842899
19pore complex assembly (GO:0046931)5.47606608
20negative regulation of fibrinolysis (GO:0051918)5.45330272
21complement activation, alternative pathway (GO:0006957)5.43926983
22protein carboxylation (GO:0018214)5.43576652
23peptidyl-glutamic acid carboxylation (GO:0017187)5.43576652
24regulation of protein activation cascade (GO:2000257)5.33657826
25regulation of fibrinolysis (GO:0051917)5.26689694
26urea cycle (GO:0000050)5.23555241
27urea metabolic process (GO:0019627)5.23555241
28regulation of complement activation (GO:0030449)5.03348594
29cysteine metabolic process (GO:0006534)5.02687170
30high-density lipoprotein particle remodeling (GO:0034375)4.87987603
31bile acid metabolic process (GO:0008206)4.87532009
32sulfur amino acid catabolic process (GO:0000098)4.83794186
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.79778986
34sister chromatid segregation (GO:0000819)4.78617503
35nitrogen cycle metabolic process (GO:0071941)4.73631153
36monoubiquitinated protein deubiquitination (GO:0035520)4.66324719
37serine family amino acid catabolic process (GO:0009071)4.63727573
38homocysteine metabolic process (GO:0050667)4.63163168
39tyrosine metabolic process (GO:0006570)4.58911135
40aromatic amino acid family metabolic process (GO:0009072)4.58712389
41regulation of triglyceride catabolic process (GO:0010896)4.44687392
42mitotic sister chromatid segregation (GO:0000070)4.43616401
43DNA unwinding involved in DNA replication (GO:0006268)4.32581050
44reverse cholesterol transport (GO:0043691)4.30586905
45alpha-amino acid catabolic process (GO:1901606)4.27470824
46glycine metabolic process (GO:0006544)4.23260251
47lysine metabolic process (GO:0006553)4.22237008
48lysine catabolic process (GO:0006554)4.22237008
49plasma lipoprotein particle clearance (GO:0034381)4.22097446
50acylglycerol homeostasis (GO:0055090)4.20779594
51triglyceride homeostasis (GO:0070328)4.20779594
52negative regulation of sterol transport (GO:0032372)4.20055001
53negative regulation of cholesterol transport (GO:0032375)4.20055001
54cellular glucuronidation (GO:0052695)4.19249759
55imidazole-containing compound metabolic process (GO:0052803)4.18474177
56regulation of DNA endoreduplication (GO:0032875)4.15599635
57protein-lipid complex remodeling (GO:0034368)4.13722844
58macromolecular complex remodeling (GO:0034367)4.13722844
59plasma lipoprotein particle remodeling (GO:0034369)4.13722844
60mitotic chromosome condensation (GO:0007076)4.10362946
61ethanol oxidation (GO:0006069)4.10274840
62amino-acid betaine metabolic process (GO:0006577)4.07767700
63indolalkylamine metabolic process (GO:0006586)4.06870210
64serine family amino acid biosynthetic process (GO:0009070)4.06261639
65bile acid and bile salt transport (GO:0015721)4.05953898
66amine catabolic process (GO:0009310)4.05713166
67cellular biogenic amine catabolic process (GO:0042402)4.05713166
68regulation of cholesterol esterification (GO:0010872)4.03106231
69serine family amino acid metabolic process (GO:0009069)3.99444183
70melanin metabolic process (GO:0006582)3.97936083
71phospholipid efflux (GO:0033700)3.97210830
72coenzyme catabolic process (GO:0009109)3.95306112
73ribosome assembly (GO:0042255)3.94845336
74fibrinolysis (GO:0042730)3.94271925
75plasma lipoprotein particle assembly (GO:0034377)3.89182716
76cellular amino acid catabolic process (GO:0009063)3.87352353
77cholesterol efflux (GO:0033344)3.86540529
78melanin biosynthetic process (GO:0042438)3.85356215
79very-low-density lipoprotein particle assembly (GO:0034379)3.84824793
80mitotic nuclear envelope disassembly (GO:0007077)3.82475929
81benzene-containing compound metabolic process (GO:0042537)3.78953544
82positive regulation of fatty acid beta-oxidation (GO:0032000)3.78277038
83glutamate metabolic process (GO:0006536)3.76184563
84negative regulation of DNA repair (GO:0045738)3.67600011
85complement activation (GO:0006956)3.67193551
86cellular ketone body metabolic process (GO:0046950)3.67118912
87cellular modified amino acid catabolic process (GO:0042219)3.65541405
88complement activation, classical pathway (GO:0006958)3.64542652
89uronic acid metabolic process (GO:0006063)3.64476445
90glucuronate metabolic process (GO:0019585)3.64476445
91arginine metabolic process (GO:0006525)3.64429124
92sister chromatid cohesion (GO:0007062)3.63493586
93protein-lipid complex assembly (GO:0065005)3.62960330
94double-strand break repair via nonhomologous end joining (GO:0006303)3.62320047
95non-recombinational repair (GO:0000726)3.62320047
96dicarboxylic acid biosynthetic process (GO:0043650)3.62218550
97phospholipid homeostasis (GO:0055091)3.61882559
98membrane disassembly (GO:0030397)3.61085242
99nuclear envelope disassembly (GO:0051081)3.61085242
100aldehyde catabolic process (GO:0046185)3.60501133
101protein activation cascade (GO:0072376)3.60392508
102cytolysis (GO:0019835)3.59971473
103cholesterol homeostasis (GO:0042632)3.59736730
104regulation of sister chromatid cohesion (GO:0007063)3.59599297
105regulation of bile acid biosynthetic process (GO:0070857)3.59330129
106positive regulation of lipid catabolic process (GO:0050996)3.58536227
107blood coagulation, intrinsic pathway (GO:0007597)3.56038658
108sterol homeostasis (GO:0055092)3.53619943
109DNA duplex unwinding (GO:0032508)3.52601249
110acetyl-CoA metabolic process (GO:0006084)3.52600998
111DNA geometric change (GO:0032392)3.50314551
112opsonization (GO:0008228)3.49575634
113regulation of RNA export from nucleus (GO:0046831)3.48330231
114low-density lipoprotein particle remodeling (GO:0034374)3.47964076
115negative regulation of lipase activity (GO:0060192)3.47762842
116regulation of cholesterol homeostasis (GO:2000188)3.45984484
117midgut development (GO:0007494)3.45937862
118cofactor catabolic process (GO:0051187)3.37151020
119organic acid catabolic process (GO:0016054)3.34979569
120carboxylic acid catabolic process (GO:0046395)3.34979569
121positive regulation of lipoprotein lipase activity (GO:0051006)3.34774317
122positive regulation of triglyceride lipase activity (GO:0061365)3.34774317
123epoxygenase P450 pathway (GO:0019373)3.34375247
124negative regulation of fibroblast apoptotic process (GO:2000270)3.33831922
125very long-chain fatty acid metabolic process (GO:0000038)3.32965825
126plasma lipoprotein particle organization (GO:0071827)3.32526320
127protein localization to kinetochore (GO:0034501)3.30725523
128positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.28653150
129positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.28653150
130positive regulation of mitotic sister chromatid separation (GO:1901970)3.28653150
131regulation of mitotic spindle organization (GO:0060236)3.15117577
132definitive hemopoiesis (GO:0060216)3.14796488
133regulation of centriole replication (GO:0046599)3.13354207
134kinetochore organization (GO:0051383)3.10652892
135paraxial mesoderm development (GO:0048339)3.09662194
136pre-miRNA processing (GO:0031054)3.07900451
137protein localization to chromosome, centromeric region (GO:0071459)3.07378470
138meiotic chromosome segregation (GO:0045132)3.06581441
139DNA conformation change (GO:0071103)3.06217261
140positive regulation of chromosome segregation (GO:0051984)3.04959173
141secondary metabolite biosynthetic process (GO:0044550)3.03516625
142DNA topological change (GO:0006265)2.98276948
143DNA replication-dependent nucleosome assembly (GO:0006335)2.95966747
144DNA replication-dependent nucleosome organization (GO:0034723)2.95966747
145chromosome condensation (GO:0030261)2.92451980
146regulation of mitotic metaphase/anaphase transition (GO:0030071)2.91617255
147regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.91617255
148DNA strand elongation involved in DNA replication (GO:0006271)2.90939709
149regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.90223942
150mitotic G2/M transition checkpoint (GO:0044818)2.89530812
151spindle checkpoint (GO:0031577)2.88522161
152regulation of chromosome segregation (GO:0051983)2.88482841
153mitotic metaphase plate congression (GO:0007080)2.87772089
154regulation of sister chromatid segregation (GO:0033045)2.86757542
155regulation of mitotic sister chromatid separation (GO:0010965)2.86757542
156regulation of mitotic sister chromatid segregation (GO:0033047)2.86757542
157DNA replication initiation (GO:0006270)2.86057593
158negative regulation of chromosome segregation (GO:0051985)2.85882599
159mitotic spindle checkpoint (GO:0071174)2.80483116
160positive regulation of SMAD protein import into nucleus (GO:0060391)2.79623754
161DNA strand elongation (GO:0022616)2.77695168
162metaphase plate congression (GO:0051310)2.77552828
163regulation of centrosome duplication (GO:0010824)2.76264673
164negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.76030426
165negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.76030426
166negative regulation of mitotic sister chromatid segregation (GO:0033048)2.76030426
167negative regulation of mitotic sister chromatid separation (GO:2000816)2.76030426
168negative regulation of sister chromatid segregation (GO:0033046)2.76030426
169mitotic spindle assembly checkpoint (GO:0007094)2.74075688
170DNA packaging (GO:0006323)2.73097237
171embryonic viscerocranium morphogenesis (GO:0048703)2.71417956
172spindle assembly checkpoint (GO:0071173)2.71063512
173nuclear envelope organization (GO:0006998)2.71047695
174regulation of nucleobase-containing compound transport (GO:0032239)2.71019714
175regulation of spindle organization (GO:0090224)2.69474612
176regulation of histone H3-K9 methylation (GO:0051570)2.68404321
177melanocyte differentiation (GO:0030318)2.67266623
178establishment of chromosome localization (GO:0051303)2.65045519
179CENP-A containing nucleosome assembly (GO:0034080)2.63335769
180mitotic G2 DNA damage checkpoint (GO:0007095)2.62328918
181chondrocyte proliferation (GO:0035988)2.62143688
182chromosome segregation (GO:0007059)2.61142843
183segment specification (GO:0007379)2.60815204
184chromatin remodeling at centromere (GO:0031055)2.59799940
185mitotic recombination (GO:0006312)2.58837353
186regulation of centrosome cycle (GO:0046605)2.58771127
187somatic hypermutation of immunoglobulin genes (GO:0016446)2.56859589
188somatic diversification of immune receptors via somatic mutation (GO:0002566)2.56859589
189negative regulation of histone methylation (GO:0031061)2.56823068
190histone-serine phosphorylation (GO:0035404)2.56275425
191regulation of fibroblast apoptotic process (GO:2000269)2.55435010
192positive regulation of DNA-dependent DNA replication (GO:2000105)2.54804497
193mRNA transport (GO:0051028)2.54186811
194regulation of transforming growth factor beta2 production (GO:0032909)2.54127595
195nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.51832349
196genitalia morphogenesis (GO:0035112)2.50196880
197somatic recombination of immunoglobulin gene segments (GO:0016447)2.49251861
198negative regulation of DNA-dependent DNA replication (GO:2000104)2.49226799
199metanephric mesenchyme development (GO:0072075)2.48289826
200generation of neurons (GO:0048699)2.47635431

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.76563373
2RXR_22158963_ChIP-Seq_LIVER_Mouse7.61923796
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.69639148
4PPARA_22158963_ChIP-Seq_LIVER_Mouse6.55984735
5LXR_22158963_ChIP-Seq_LIVER_Mouse6.19526086
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.48281767
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.46731673
8E2F4_17652178_ChIP-ChIP_JURKAT_Human4.05418495
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.04751537
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.78214252
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.49878778
12KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.40494657
13EGR1_19374776_ChIP-ChIP_THP-1_Human3.01264931
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.45287894
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.43604731
16CLOCK_20551151_ChIP-Seq_293T_Human2.37016527
17ELK1_19687146_ChIP-ChIP_HELA_Human2.35000512
18FUS_26573619_Chip-Seq_HEK293_Human2.13044542
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.01242291
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.8836327
21RBPJ_22232070_ChIP-Seq_NCS_Mouse1.96780447
22* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.88977108
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84339313
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78813419
25FOXA2_19822575_ChIP-Seq_HepG2_Human1.77804940
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.77733691
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.75109963
28HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.73339433
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.71795017
30* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71010899
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.70509092
32GATA1_22025678_ChIP-Seq_K562_Human1.62881152
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60560480
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60481218
35PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.60349137
36EWS_26573619_Chip-Seq_HEK293_Human1.59238072
37IRF8_22096565_ChIP-ChIP_GC-B_Human1.57269622
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53218741
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52299943
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47150726
41TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.46517200
42HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.39633976
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.39377344
44MYC_22102868_ChIP-Seq_BL_Human1.39324859
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.37851491
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34885066
47STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.33655612
48MYC_19079543_ChIP-ChIP_MESCs_Mouse1.33306855
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.32607924
50CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.32264885
51HNF4A_19822575_ChIP-Seq_HepG2_Human1.30506172
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29524368
53TFEB_21752829_ChIP-Seq_HELA_Human1.28724825
54SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.28061390
55FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.26740172
56SALL4_18804426_ChIP-ChIP_XEN_Mouse1.24391234
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22377983
58BRD4_25478319_ChIP-Seq_HGPS_Human1.21524313
59HTT_18923047_ChIP-ChIP_STHdh_Human1.19478706
60CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18990410
61NELFA_20434984_ChIP-Seq_ESCs_Mouse1.18929230
62MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18877316
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17739008
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16721474
65Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16353178
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15496890
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12144752
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11057951
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.10933828
70TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10369642
71SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.10078047
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.09926202
73RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05902077
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.05038270
75CREB1_15753290_ChIP-ChIP_HEK293T_Human1.04981285
76PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.04857438
77SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04355043
78CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.03690294
79CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03285283
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01871150
81FOXO3_23340844_ChIP-Seq_DLD1_Human1.01186517
82AR_21909140_ChIP-Seq_LNCAP_Human1.00976036
83SOX17_20123909_ChIP-Seq_XEN_Mouse1.00414972
84EZH2_27294783_Chip-Seq_NPCs_Mouse0.99904360
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99074228
86KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.98988528
87FOXP3_21729870_ChIP-Seq_TREG_Human0.98740342
88POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98247414
89CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97905189
90NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97741649
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97741649
92RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97651039
93NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96462338
94* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95139335
95SCL_19346495_ChIP-Seq_HPC-7_Human0.94909741
96NANOG_16153702_ChIP-ChIP_HESCs_Human0.94419187
97CHD1_26751641_Chip-Seq_LNCaP_Human0.94313164
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93166204
99ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93156618
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92725826
101NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90816769
102STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.89904660
103PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89703781
104SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89165215
105RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.88025344
106IRF8_27001747_Chip-Seq_BMDM_Mouse0.87603408
107GATA4_25053715_ChIP-Seq_YYC3_Human0.87391125
108FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86942154
109MYB_26560356_Chip-Seq_TH2_Human0.86090225
110SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.85840085
111WT1_19549856_ChIP-ChIP_CCG9911_Human0.85830953
112DCP1A_22483619_ChIP-Seq_HELA_Human0.85784955
113SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.85681638
114NFIB_24661679_ChIP-Seq_LUNG_Mouse0.85258805
115NFE2_27457419_Chip-Seq_LIVER_Mouse0.84669981
116P300_19829295_ChIP-Seq_ESCs_Human0.84427573
117KDM5A_27292631_Chip-Seq_BREAST_Human0.83979921
118VDR_23849224_ChIP-Seq_CD4+_Human0.83787128
119BRD4_27068464_Chip-Seq_AML-cells_Mouse0.83652558
120SMAD3_21741376_ChIP-Seq_EPCs_Human0.83516324
121ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82816688
122PCGF2_27294783_Chip-Seq_NPCs_Mouse0.82807455
123PPAR_26484153_Chip-Seq_NCI-H1993_Human0.81091975
124TTF2_22483619_ChIP-Seq_HELA_Human0.80943191
125ERG_20887958_ChIP-Seq_HPC-7_Mouse0.80484495
126BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80063475
127THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78992154
128E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.78965674
129RXRA_24833708_ChIP-Seq_LIVER_Mouse0.78648130
130AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.78160896
131KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.77910250
132KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.77910250
133KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.77910250
134OCT4_21477851_ChIP-Seq_ESCs_Mouse0.76755575
135TBX3_20139965_ChIP-Seq_ESCs_Mouse0.76514454
136ESR1_20079471_ChIP-ChIP_T-47D_Human0.76458232
137DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.75921725
138TBX3_20139965_ChIP-Seq_MESCs_Mouse0.75304631
139PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.74633807
140TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.73850650
141ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.73833551
142FOXA1_25552417_ChIP-Seq_VCAP_Human0.72660324
143ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.72578032
144RUNX_20019798_ChIP-Seq_JUKART_Human0.71376794
145CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.69005149
146CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.68017214
147PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.67912671
148TRIM28_21343339_ChIP-Seq_HEK293_Human0.67617422
149FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.67361492
150TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.67124208
151FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.66270014
152FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.65119191
153GATA2_21666600_ChIP-Seq_HMVEC_Human0.64792768
154AUTS2_25519132_ChIP-Seq_293T-REX_Human0.64602681
155MYB_21317192_ChIP-Seq_ERMYB_Mouse0.62283350
156IRF8_21731497_ChIP-ChIP_J774_Mouse0.62135051
157IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.62074640
158SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.61714132
159CDX2_20551321_ChIP-Seq_CACO-2_Human0.60494250
160ESR1_21235772_ChIP-Seq_MCF-7_Human0.60285193
161ESR2_21235772_ChIP-Seq_MCF-7_Human0.60170766
162GATA1_19941826_ChIP-Seq_K562_Human0.59543909
163KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.58343398
164ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.57866928
165FOXM1_23109430_ChIP-Seq_U2OS_Human0.57338440
166EGR1_19032775_ChIP-ChIP_M12_Human0.55796436
167CEBPB_22108803_ChIP-Seq_LS180_Human0.55407530
168GATA2_19941826_ChIP-Seq_K562_Human0.54385796
169CJUN_26792858_Chip-Seq_BT549_Human0.54227160
170SALL1_21062744_ChIP-ChIP_HESCs_Human0.54190514
171FOXM1_26456572_ChIP-Seq_MCF-7_Human0.51330126
172GATA6_25053715_ChIP-Seq_YYC3_Human0.50941638
173VDR_24787735_ChIP-Seq_THP-1_Human0.50884248
174KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.50715944
175SOX2_20726797_ChIP-Seq_SW620_Human0.49308367
176SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.49100211
177RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.47805234
178TBX20_22328084_ChIP-Seq_HEART_Mouse0.47784451
179TBX20_22080862_ChIP-Seq_HEART_Mouse0.47784451
180FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.46723425
181PU_27001747_Chip-Seq_BMDM_Mouse0.45733250
182MYB_26560356_Chip-Seq_TH1_Human0.44697253

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.59618606
2MP0005360_urolithiasis6.85049052
3MP0005085_abnormal_gallbladder_physiolo5.72957609
4MP0005365_abnormal_bile_salt5.43504597
5MP0008057_abnormal_DNA_replication4.35427303
6MP0008875_abnormal_xenobiotic_pharmacok4.34976754
7MP0003252_abnormal_bile_duct3.92085523
8MP0005171_absent_coat_pigmentation3.70405054
9MP0003806_abnormal_nucleotide_metabolis3.69484732
10MP0010094_abnormal_chromosome_stability3.20084565
11MP0000569_abnormal_digit_pigmentation3.11151587
12MP0000372_irregular_coat_pigmentation3.10974035
13MP0010329_abnormal_lipoprotein_level3.10183174
14MP0000015_abnormal_ear_pigmentation2.95460143
15MP0002009_preneoplasia2.91359337
16MP0009840_abnormal_foam_cell2.81250573
17MP0002396_abnormal_hematopoietic_system2.81047951
18MP0003890_abnormal_embryonic-extraembry2.49728415
19MP0005083_abnormal_biliary_tract2.47890464
20MP0003111_abnormal_nucleus_morphology2.42419270
21MP0008007_abnormal_cellular_replicative2.38813856
22MP0010352_gastrointestinal_tract_polyps2.38038783
23MP0003077_abnormal_cell_cycle2.37617166
24MP0003136_yellow_coat_color2.27711585
25MP0001666_abnormal_nutrient_absorption2.25754827
26MP0005332_abnormal_amino_acid2.25396302
27MP0002877_abnormal_melanocyte_morpholog2.22375370
28MP0003191_abnormal_cellular_cholesterol2.15948068
29MP0003195_calcinosis2.13516205
30MP0005174_abnormal_tail_pigmentation2.12343713
31MP0000609_abnormal_liver_physiology2.01325894
32MP0002138_abnormal_hepatobiliary_system2.01034205
33MP0004957_abnormal_blastocyst_morpholog2.00035587
34MP0003705_abnormal_hypodermis_morpholog1.92385586
35MP0010368_abnormal_lymphatic_system1.85400142
36MP0010307_abnormal_tumor_latency1.81028602
37MP0003693_abnormal_embryo_hatching1.80129736
38MP0000371_diluted_coat_color1.79615795
39MP0002118_abnormal_lipid_homeostasis1.77529450
40MP0003868_abnormal_feces_composition1.74269275
41MP0005075_abnormal_melanosome_morpholog1.74003093
42MP0004808_abnormal_hematopoietic_stem1.70159550
43MP0004019_abnormal_vitamin_homeostasis1.59943068
44MP0010030_abnormal_orbit_morphology1.59782021
45MP0009697_abnormal_copulation1.59167232
46MP0003763_abnormal_thymus_physiology1.57081014
47MP0002095_abnormal_skin_pigmentation1.56840256
48MP0000350_abnormal_cell_proliferation1.56577743
49MP0005319_abnormal_enzyme/_coenzyme1.51402556
50MP0001730_embryonic_growth_arrest1.49225344
51MP0008058_abnormal_DNA_repair1.42959362
52MP0001672_abnormal_embryogenesis/_devel1.41221975
53MP0005380_embryogenesis_phenotype1.41221975
54MP0008932_abnormal_embryonic_tissue1.40886835
55MP0008438_abnormal_cutaneous_collagen1.37984731
56MP0003984_embryonic_growth_retardation1.34334510
57MP0002075_abnormal_coat/hair_pigmentati1.33089241
58MP0009053_abnormal_anal_canal1.32866158
59MP0002088_abnormal_embryonic_growth/wei1.31590708
60MP0003937_abnormal_limbs/digits/tail_de1.30399812
61MP0010234_abnormal_vibrissa_follicle1.29578404
62MP0005503_abnormal_tendon_morphology1.29569179
63MP0000428_abnormal_craniofacial_morphol1.28256046
64MP0002084_abnormal_developmental_patter1.28060541
65MP0005275_abnormal_skin_tensile1.27719004
66MP0000733_abnormal_muscle_development1.27068193
67MP0003011_delayed_dark_adaptation1.26842317
68MP0005408_hypopigmentation1.25426498
69MP0000598_abnormal_liver_morphology1.23905777
70MP0005584_abnormal_enzyme/coenzyme_acti1.23761857
71MP0001697_abnormal_embryo_size1.22313937
72MP0002086_abnormal_extraembryonic_tissu1.17982796
73MP0002085_abnormal_embryonic_tissue1.13786906
74MP0005451_abnormal_body_composition1.13475730
75MP0003385_abnormal_body_wall1.13180031
76MP0001764_abnormal_homeostasis1.11855737
77MP0005647_abnormal_sex_gland1.11084575
78MP0009763_increased_sensitivity_to1.10995184
79MP0001186_pigmentation_phenotype1.10104144
80MP0009384_cardiac_valve_regurgitation1.08864363
81MP0003935_abnormal_craniofacial_develop1.08830030
82MP0002938_white_spotting1.07676008
83MP0004084_abnormal_cardiac_muscle1.05711513
84MP0003755_abnormal_palate_morphology1.04524313
85MP0005409_darkened_coat_color1.04342020
86MP0005257_abnormal_intraocular_pressure1.02909611
87MP0001324_abnormal_eye_pigmentation1.02820897
88MP0009250_abnormal_appendicular_skeleto1.02608923
89MP0002080_prenatal_lethality1.00562600
90MP0003186_abnormal_redox_activity0.99691897
91MP0003567_abnormal_fetal_cardiomyocyte0.97997312
92MP0005197_abnormal_uvea_morphology0.97540102
93MP0009764_decreased_sensitivity_to0.97428151
94MP0009643_abnormal_urine_homeostasis0.96861755
95MP0002932_abnormal_joint_morphology0.96826463
96MP0003656_abnormal_erythrocyte_physiolo0.93514821
97MP0002177_abnormal_outer_ear0.93141665
98MP0000432_abnormal_head_morphology0.91513126
99MP0001299_abnormal_eye_distance/0.91370270
100MP0001286_abnormal_eye_development0.91114927
101MP0003690_abnormal_glial_cell0.90048957
102MP0002006_tumorigenesis0.88187295
103MP0002102_abnormal_ear_morphology0.88080407
104MP0008469_abnormal_protein_level0.87894818
105MP0003566_abnormal_cell_adhesion0.86899922
106MP0001661_extended_life_span0.85823720
107* MP0002109_abnormal_limb_morphology0.82745725
108MP0002925_abnormal_cardiovascular_devel0.81580591
109MP0004197_abnormal_fetal_growth/weight/0.81568665
110MP0005248_abnormal_Harderian_gland0.79455119
111MP0000313_abnormal_cell_death0.77696541
112MP0009765_abnormal_xenobiotic_induced0.77271783
113MP0003300_gastrointestinal_ulcer0.77240655
114MP0003786_premature_aging0.77010861
115MP0002233_abnormal_nose_morphology0.76005701
116* MP0002114_abnormal_axial_skeleton0.75410721
117MP0003724_increased_susceptibility_to0.74834277
118MP0002254_reproductive_system_inflammat0.74570648
119MP0004134_abnormal_chest_morphology0.74354029
120MP0003091_abnormal_cell_migration0.74182329
121MP0001879_abnormal_lymphatic_vessel0.73549170
122MP0005220_abnormal_exocrine_pancreas0.73491218
123MP0005076_abnormal_cell_differentiation0.72847530
124MP0005621_abnormal_cell_physiology0.69568720
125MP0000604_amyloidosis0.69551497
126MP0009703_decreased_birth_body0.68948892
127MP0001177_atelectasis0.68480724
128MP0002111_abnormal_tail_morphology0.67861035
129MP0000534_abnormal_ureter_morphology0.67557876
130MP0006082_CNS_inflammation0.67040748
131MP0001915_intracranial_hemorrhage0.66355230
132MP0002019_abnormal_tumor_incidence0.66325224
133MP0009642_abnormal_blood_homeostasis0.65279353
134MP0009333_abnormal_splenocyte_physiolog0.64915942
135MP0002928_abnormal_bile_duct0.64209536
136MP0002971_abnormal_brown_adipose0.62804413
137MP0003436_decreased_susceptibility_to0.62484852
138MP0001243_abnormal_dermal_layer0.62270188
139MP0002282_abnormal_trachea_morphology0.62146155
140MP0005464_abnormal_platelet_physiology0.62000998
141MP0004130_abnormal_muscle_cell0.61275047
142MP0005023_abnormal_wound_healing0.59522978
143MP0005376_homeostasis/metabolism_phenot0.57338595
144MP0000566_synostosis0.57283502
145MP0009672_abnormal_birth_weight0.57105793
146MP0005334_abnormal_fat_pad0.56366022
147MP0002060_abnormal_skin_morphology0.56327719
148MP0003453_abnormal_keratinocyte_physiol0.55885516
149MP0005666_abnormal_adipose_tissue0.55799481
150MP0002092_abnormal_eye_morphology0.54363900
151MP0000639_abnormal_adrenal_gland0.53780765
152MP0004272_abnormal_basement_membrane0.53464646
153MP0002128_abnormal_blood_circulation0.52671207
154MP0004381_abnormal_hair_follicle0.52646494
155MP0000767_abnormal_smooth_muscle0.52506877
156MP0010678_abnormal_skin_adnexa0.52392109
157MP0005670_abnormal_white_adipose0.52259170
158MP0000249_abnormal_blood_vessel0.51231227
159MP0005084_abnormal_gallbladder_morpholo0.49976491
160MP0006054_spinal_hemorrhage0.49255140
161MP0003279_aneurysm0.45738320
162MP0002249_abnormal_larynx_morphology0.45572185
163MP0002136_abnormal_kidney_physiology0.45365486
164MP0000920_abnormal_myelination0.45271896
165MP0002168_other_aberrant_phenotype0.45074987
166MP0003115_abnormal_respiratory_system0.43871294
167MP0002697_abnormal_eye_size0.42641462
168MP0009115_abnormal_fat_cell0.42532335
169MP0003943_abnormal_hepatobiliary_system0.42295324
170MP0004185_abnormal_adipocyte_glucose0.42167617
171MP0000383_abnormal_hair_follicle0.42167616
172MP0002166_altered_tumor_susceptibility0.42133394
173MP0005395_other_phenotype0.41717311
174MP0000685_abnormal_immune_system0.41608623
175MP0002419_abnormal_innate_immunity0.41562497
176MP0005636_abnormal_mineral_homeostasis0.41405392
177MP0003950_abnormal_plasma_membrane0.41105912
178MP0000377_abnormal_hair_follicle0.40580258
179MP0000427_abnormal_hair_cycle0.39305133
180MP0008873_increased_physiological_sensi0.38840776
181MP0001845_abnormal_inflammatory_respons0.37978680
182MP0004782_abnormal_surfactant_physiolog0.36770358

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.63325687
2Intrahepatic cholestasis (HP:0001406)7.41556036
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.80355880
4Prolonged partial thromboplastin time (HP:0003645)6.24794487
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.20857764
6Xanthomatosis (HP:0000991)5.92853441
7Hypobetalipoproteinemia (HP:0003563)5.92314798
8Complement deficiency (HP:0004431)5.60314354
9Hyperlipoproteinemia (HP:0010980)5.13038868
10Joint hemorrhage (HP:0005261)4.66225794
11Epidermoid cyst (HP:0200040)4.56536856
12Abnormality of the common coagulation pathway (HP:0010990)4.50238666
13Hypolipoproteinemia (HP:0010981)4.41926601
14Volvulus (HP:0002580)4.28903743
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.15415283
16Abnormality of complement system (HP:0005339)4.11754097
17Abnormality of methionine metabolism (HP:0010901)4.11010283
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.05971946
19Hyperammonemia (HP:0001987)4.02613093
20Fat malabsorption (HP:0002630)3.93472848
21Abnormality of aspartate family amino acid metabolism (HP:0010899)3.90628598
22Hypoalphalipoproteinemia (HP:0003233)3.85922449
23Abnormality of glutamine family amino acid metabolism (HP:0010902)3.71461966
24Abnormality of pyrimidine metabolism (HP:0004353)3.60946476
25Ketosis (HP:0001946)3.60259435
26Chromosomal breakage induced by crosslinking agents (HP:0003221)3.57536926
27Hyperglycinemia (HP:0002154)3.56699936
28Hypercholesterolemia (HP:0003124)3.53584365
29Abnormality of the intrinsic pathway (HP:0010989)3.47314646
30Chromsome breakage (HP:0040012)3.35306067
31Myocardial infarction (HP:0001658)3.33545957
32Abnormality of glycine metabolism (HP:0010895)3.30000961
33Abnormality of serine family amino acid metabolism (HP:0010894)3.30000961
34Hypoglycemic coma (HP:0001325)3.26605435
35Hepatocellular carcinoma (HP:0001402)3.20584011
36Conjugated hyperbilirubinemia (HP:0002908)3.20496440
37Increased nuchal translucency (HP:0010880)3.10963983
38Steatorrhea (HP:0002570)3.04686487
39Hyperglycinuria (HP:0003108)3.02333784
40Systemic lupus erythematosus (HP:0002725)2.99291839
41Hypochromic microcytic anemia (HP:0004840)2.99072905
42Abnormality of chromosome stability (HP:0003220)2.92525513
43Mitral stenosis (HP:0001718)2.87341782
44Hyperbilirubinemia (HP:0002904)2.82516259
45Syringomyelia (HP:0003396)2.81145501
46Spinal cord lesions (HP:0100561)2.81145501
47Spastic diplegia (HP:0001264)2.79945071
48Spontaneous abortion (HP:0005268)2.77578207
49Recurrent gram-negative bacterial infections (HP:0005420)2.76879804
50Deep philtrum (HP:0002002)2.75852582
51Premature rupture of membranes (HP:0001788)2.68301887
52Esophageal varix (HP:0002040)2.68063542
53Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.66686870
54Heterotopia (HP:0002282)2.65497143
55Abnormality of nucleobase metabolism (HP:0010932)2.63503370
56Skin nodule (HP:0200036)2.62966789
57Abnormality of fatty-acid metabolism (HP:0004359)2.62401783
58Ankyloglossia (HP:0010296)2.60178670
59Delayed CNS myelination (HP:0002188)2.59917916
60Gingival bleeding (HP:0000225)2.59285946
61Vascular calcification (HP:0004934)2.56972058
62Abnormality of serum amino acid levels (HP:0003112)2.52688009
63Cardiovascular calcification (HP:0011915)2.48414046
64White forelock (HP:0002211)2.47102334
65Glomerulonephritis (HP:0000099)2.46847348
66Transitional cell carcinoma of the bladder (HP:0006740)2.46283731
67Embryonal renal neoplasm (HP:0011794)2.46044702
68Aplasia/Hypoplasia of the uvula (HP:0010293)2.45538356
69Hypopigmentation of the fundus (HP:0007894)2.45538207
70Bladder neoplasm (HP:0009725)2.41882909
71Bladder carcinoma (HP:0002862)2.41882909
72Acanthocytosis (HP:0001927)2.37047835
73Abnormality of oral frenula (HP:0000190)2.36003334
74Cutaneous melanoma (HP:0012056)2.34760791
75Patchy hypopigmentation of hair (HP:0011365)2.33214863
76Asymmetry of the thorax (HP:0001555)2.32636664
77Hypoplasia of the fovea (HP:0007750)2.31683532
78Aplasia/Hypoplasia of the fovea (HP:0008060)2.31683532
79Thrombophlebitis (HP:0004418)2.31211472
80Abnormal auditory evoked potentials (HP:0006958)2.30911571
81Thickened helices (HP:0000391)2.29834201
82Abnormality of the preputium (HP:0100587)2.29562239
83Hemorrhage of the eye (HP:0011885)2.28518476
84Albinism (HP:0001022)2.26923204
85Curly hair (HP:0002212)2.26645215
86Nephroblastoma (Wilms tumor) (HP:0002667)2.26643208
87Meckel diverticulum (HP:0002245)2.25818238
88Uterine leiomyosarcoma (HP:0002891)2.25568725
89Leiomyosarcoma (HP:0100243)2.25568725
90Enlarged kidneys (HP:0000105)2.25048038
91Overlapping toe (HP:0001845)2.23106834
92Short middle phalanx of the 5th finger (HP:0004220)2.22207223
93Abnormality of the ileum (HP:0001549)2.17319578
94Deviation of the thumb (HP:0009603)2.17302000
95Freckling (HP:0001480)2.16995689
96Ketoacidosis (HP:0001993)2.15546463
97Pulmonary embolism (HP:0002204)2.15506919
98Abnormality of purine metabolism (HP:0004352)2.14781817
99Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.14274083
100Ectopic kidney (HP:0000086)2.12841006
101Myelodysplasia (HP:0002863)2.12135206
102Blue irides (HP:0000635)2.11396229
103Proximal placement of thumb (HP:0009623)2.10237820
104Gastrointestinal carcinoma (HP:0002672)2.09504741
105Malignant gastrointestinal tract tumors (HP:0006749)2.09504741
106Increased mean platelet volume (HP:0011877)2.03350879
107Metabolic acidosis (HP:0001942)2.03266314
108Aortic dissection (HP:0002647)2.02650912
109Duodenal stenosis (HP:0100867)2.02190147
110Small intestinal stenosis (HP:0012848)2.02190147
111Cafe-au-lait spot (HP:0000957)2.01186049
112Amyloidosis (HP:0011034)2.01181444
113Rhabdomyosarcoma (HP:0002859)2.00851142
114Hypoglycemic seizures (HP:0002173)2.00096960
115Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.97438450
116Abnormal cartilage morphology (HP:0002763)1.97248389
117Aplasia/Hypoplasia of the macula (HP:0008059)1.97205778
118Abnormality of iron homeostasis (HP:0011031)1.93750687
119Menorrhagia (HP:0000132)1.93611769
120Low anterior hairline (HP:0000294)1.92248122
121Sandal gap (HP:0001852)1.92065957
122Abnormality of dicarboxylic acid metabolism (HP:0010995)1.90925160
123Dicarboxylic aciduria (HP:0003215)1.90925160
124Opisthotonus (HP:0002179)1.89925204
125Large earlobe (HP:0009748)1.89007616
126Arteriovenous malformation (HP:0100026)1.88663968
127Clubbing of toes (HP:0100760)1.88590464
128Abnormal lung lobation (HP:0002101)1.87586135
129Abnormal gallbladder morphology (HP:0012437)1.86778470
130Submucous cleft hard palate (HP:0000176)1.86534442
131Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.86416024
132Pseudobulbar signs (HP:0002200)1.85619288
133Abnormality of the fovea (HP:0000493)1.85145350
134Nephritis (HP:0000123)1.85088756
135Abnormal platelet volume (HP:0011876)1.84075686
136Conjunctival telangiectasia (HP:0000524)1.83354863
137Calcaneovalgus deformity (HP:0001848)1.83277421
138Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.82546578
139Peritonitis (HP:0002586)1.82022514
140Abnormality of the epiphyses of the hand (HP:0005924)1.81343224
141Abnormality of the calcaneus (HP:0008364)1.80930147
142Abnormal enzyme/coenzyme activity (HP:0012379)1.80360148
143Acute myeloid leukemia (HP:0004808)1.79901525
144Synophrys (HP:0000664)1.79649156
145Mitral valve prolapse (HP:0001634)1.79599634
146Anal stenosis (HP:0002025)1.79431284
147Abnormality of chromosome segregation (HP:0002916)1.79329959
148Hypophosphatemic rickets (HP:0004912)1.79161311
149Absent radius (HP:0003974)1.78497350
150Abnormality of the duodenum (HP:0002246)1.78473029
151Long eyelashes (HP:0000527)1.77729005
152Abnormal foot bone ossification (HP:0010675)1.77554512
153Rickets (HP:0002748)1.76965699
154Bifid tongue (HP:0010297)1.76814543
155Abnormality of transition element cation homeostasis (HP:0011030)1.75915106
156Prominent nose (HP:0000448)1.75589226
157Cholelithiasis (HP:0001081)1.75500328
158Pancreatitis (HP:0001733)1.75213296
159Osteolytic defects of the phalanges of the hand (HP:0009771)1.75139396
160Osteolytic defects of the hand bones (HP:0009699)1.75139396
161Aplasia/Hypoplasia affecting the retina (HP:0008061)1.75079053
162Basal cell carcinoma (HP:0002671)1.73387685
163Arterial tortuosity (HP:0005116)1.73159872
164Blepharitis (HP:0000498)1.72672692
165Cystic hygroma (HP:0000476)1.71755612
166Spontaneous hematomas (HP:0007420)1.71404540
167Deep palmar crease (HP:0006191)1.70643931
168Abnormality of the carotid arteries (HP:0005344)1.70423727
169Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.69081988
170Abnormality of incisor morphology (HP:0011063)1.68976187
171Delayed closure of the anterior fontanelle (HP:0001476)1.68116086
172Radioulnar synostosis (HP:0002974)1.68026415
173Elevated hepatic transaminases (HP:0002910)1.67306321
174Neoplasm of the small intestine (HP:0100833)1.66132563
175Irritability (HP:0000737)1.65446640
176Ocular albinism (HP:0001107)1.65413217
177Lethargy (HP:0001254)1.65351752
178Elevated alkaline phosphatase (HP:0003155)1.65054966
179Ectopia lentis (HP:0001083)1.64936755
180Abnormality of the fetal cardiovascular system (HP:0010948)1.64407054
181Abnormal umbilical cord blood vessels (HP:0011403)1.64407054
182Single umbilical artery (HP:0001195)1.64407054
183Abnormality of the vasculature of the conjunctiva (HP:0008054)1.63747137
184Cubitus valgus (HP:0002967)1.62508335
185Abnormality of the lumbar spine (HP:0100712)1.62468205
186Rhizomelia (HP:0008905)1.61373613
187Sensorimotor neuropathy (HP:0007141)1.61217733
188Stroke (HP:0001297)1.61060117
189Poikilocytosis (HP:0004447)1.60241022
190Facial hemangioma (HP:0000329)1.59428583
191Neonatal onset (HP:0003623)1.59390079
192Abnormality of proline metabolism (HP:0010907)1.58834967
193Hydroxyprolinuria (HP:0003080)1.58834967
194Megalencephaly (HP:0001355)1.58482406
195Back pain (HP:0003418)1.58478777
196Lymphangioma (HP:0100764)1.57793189
197Malnutrition (HP:0004395)1.56857354
198Abnormality of the gallbladder (HP:0005264)1.55585204
199Neoplasm of the liver (HP:0002896)1.55285501

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK13.81934450
2BCKDK3.66815283
3FGFR43.36154785
4BRSK23.34426371
5EIF2AK33.16170046
6WEE13.06053921
7MKNK22.90457378
8FGFR22.71390796
9LATS12.60107715
10PKN22.54941221
11ERN12.50509067
12MAP3K102.25735292
13ERBB42.23249940
14TRIB32.18077549
15TGFBR22.17154509
16NEK92.12961244
17ACVR1B2.11891366
18CDC72.02974708
19TTK2.00901412
20EPHB11.87772387
21PTK61.85005672
22AKT31.81397650
23ERBB31.76237292
24PNCK1.74865332
25PDK21.74644245
26TAF11.73116485
27PLK41.72313042
28KDR1.70673139
29FLT31.70073881
30MET1.67026362
31CDK31.66394929
32STK31.50794276
33SRPK11.48693482
34CDK61.48502328
35CSF1R1.47515725
36INSRR1.41625199
37CAMK1D1.41490082
38BUB11.40845722
39TSSK61.39728657
40MAPK111.37922432
41TIE11.36036114
42PLK31.35559421
43TAOK31.34345234
44IRAK21.33299284
45STK101.31679577
46BMPR1B1.26437462
47MAP4K11.26033467
48TYK21.24140587
49NUAK11.22647164
50BRSK11.21270271
51PIK3CG1.20758742
52STK38L1.20652543
53PASK1.16822918
54EIF2AK11.14976053
55MAP3K141.14285575
56ICK1.12922705
57FGFR31.12714385
58CDK121.11502270
59CSK1.10597090
60NEK11.08868049
61PBK1.07364144
62KIT1.06202801
63ITK1.02627094
64CSNK1G11.01330255
65MAP2K31.01154263
66ATR1.00727731
67MAP3K70.98888049
68CAMK1G0.98790513
69JAK10.98638943
70CSNK1A1L0.98159646
71ERBB20.96911188
72PDGFRA0.96089115
73MST1R0.94894033
74STK40.93657606
75TBK10.92923711
76CDK70.92369593
77FGFR10.91359639
78PRKAA20.90927212
79ATM0.90858539
80CHEK10.90120453
81SCYL20.89546079
82FRK0.89005639
83BLK0.87492548
84PRPF4B0.87075113
85LRRK20.86918481
86CHEK20.86909853
87TEC0.86098821
88CDK40.84572224
89STK390.84442624
90PKN10.84295378
91YES10.84114333
92GSK3A0.83919097
93CAMKK20.83738755
94DYRK1B0.83449986
95EPHA30.82669022
96JAK20.82016321
97MARK30.80829215
98TTN0.80186465
99PDGFRB0.75345888
100PLK10.74129665
101MTOR0.72730828
102NEK20.72569957
103TGFBR10.70946031
104MELK0.69448830
105CSNK1G30.68513705
106BTK0.66777806
107PRKCQ0.66321652
108MAPK40.65927479
109AURKB0.64355584
110WNK10.63674940
111MAP3K130.62764786
112RPS6KB20.62725661
113RIPK10.61756064
114PAK20.60815315
115CHUK0.59825230
116BMX0.54948967
117BMPR20.54624631
118CDK80.54242710
119ABL20.53891332
120IGF1R0.53678465
121TRIM280.51938962
122NLK0.51443504
123CLK10.51074213
124RAF10.51003871
125GRK60.50998187
126MAPK70.50540542
127IKBKE0.50278279
128ZAK0.48543256
129JAK30.48533248
130CDK10.47787228
131PTK20.46823379
132BRAF0.46341493
133ZAP700.46219126
134SGK30.45757475
135CDK20.44866951
136EGFR0.44634810
137ABL10.44595356
138DDR20.44511414
139RPS6KA40.44275057
140PIM10.43797019
141EEF2K0.43741661
142BRD40.43564151
143MAP3K80.42673544
144RPS6KB10.42556395
145SGK20.42292268
146IRAK10.41650005
147MKNK10.41571149
148EPHB20.40216827
149PLK20.39659964
150LATS20.38236650
151INSR0.37743555
152IRAK30.36968196
153TRPM70.35890930
154PRKDC0.35219303
155EIF2AK20.33903998
156IKBKB0.33534855
157GRK10.33227696

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.58948524
2Nitrogen metabolism_Homo sapiens_hsa009103.84749759
3Non-homologous end-joining_Homo sapiens_hsa034503.83506082
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.29686470
5Complement and coagulation cascades_Homo sapiens_hsa046102.99233653
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.84912119
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.84777987
8Arginine biosynthesis_Homo sapiens_hsa002202.83395208
9Cell cycle_Homo sapiens_hsa041102.81109702
10DNA replication_Homo sapiens_hsa030302.69827069
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.62437662
12Tryptophan metabolism_Homo sapiens_hsa003802.60078002
13Mismatch repair_Homo sapiens_hsa034302.58840274
14Fatty acid degradation_Homo sapiens_hsa000712.41576718
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.40131150
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.38009807
17Fanconi anemia pathway_Homo sapiens_hsa034602.33617141
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.31242903
19RNA transport_Homo sapiens_hsa030132.27202174
20Pentose and glucuronate interconversions_Homo sapiens_hsa000402.15685660
21Staphylococcus aureus infection_Homo sapiens_hsa051502.10114207
22Steroid hormone biosynthesis_Homo sapiens_hsa001402.02935819
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.01635121
24Peroxisome_Homo sapiens_hsa041462.01251196
25Butanoate metabolism_Homo sapiens_hsa006501.96499559
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.96307564
27Histidine metabolism_Homo sapiens_hsa003401.91608948
28Caffeine metabolism_Homo sapiens_hsa002321.90800473
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88812260
30PPAR signaling pathway_Homo sapiens_hsa033201.88270282
31N-Glycan biosynthesis_Homo sapiens_hsa005101.83834623
32Fatty acid metabolism_Homo sapiens_hsa012121.83372459
33Propanoate metabolism_Homo sapiens_hsa006401.82260854
34Chemical carcinogenesis_Homo sapiens_hsa052041.82045530
35Retinol metabolism_Homo sapiens_hsa008301.81524881
36mRNA surveillance pathway_Homo sapiens_hsa030151.80834163
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.76643286
38Chronic myeloid leukemia_Homo sapiens_hsa052201.73305295
39Selenocompound metabolism_Homo sapiens_hsa004501.68519980
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66957372
41Homologous recombination_Homo sapiens_hsa034401.66404184
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.65638282
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.65264919
44Nucleotide excision repair_Homo sapiens_hsa034201.63309780
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.61429983
46RNA degradation_Homo sapiens_hsa030181.61339541
47Steroid biosynthesis_Homo sapiens_hsa001001.60224617
48Colorectal cancer_Homo sapiens_hsa052101.59912907
49Non-small cell lung cancer_Homo sapiens_hsa052231.59893171
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58757046
51Fatty acid elongation_Homo sapiens_hsa000621.55286164
52beta-Alanine metabolism_Homo sapiens_hsa004101.54618547
53Thyroid cancer_Homo sapiens_hsa052161.50782017
54Pancreatic cancer_Homo sapiens_hsa052121.44644391
55Spliceosome_Homo sapiens_hsa030401.42450969
56Basal transcription factors_Homo sapiens_hsa030221.37526405
57p53 signaling pathway_Homo sapiens_hsa041151.36773490
58Bile secretion_Homo sapiens_hsa049761.33002681
59Tyrosine metabolism_Homo sapiens_hsa003501.28264377
60Phenylalanine metabolism_Homo sapiens_hsa003601.27730968
61Melanoma_Homo sapiens_hsa052181.23088208
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22916950
63Sulfur metabolism_Homo sapiens_hsa009201.20478995
64Lysine degradation_Homo sapiens_hsa003101.18878646
65Starch and sucrose metabolism_Homo sapiens_hsa005001.17505553
66ABC transporters_Homo sapiens_hsa020101.17015364
67Base excision repair_Homo sapiens_hsa034101.15903095
68Protein export_Homo sapiens_hsa030601.15579903
69Cysteine and methionine metabolism_Homo sapiens_hsa002701.13946814
70Wnt signaling pathway_Homo sapiens_hsa043101.13181378
71Hepatitis B_Homo sapiens_hsa051611.11788974
72Glioma_Homo sapiens_hsa052141.09048985
73Folate biosynthesis_Homo sapiens_hsa007901.08000994
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.06746081
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06148355
76Bladder cancer_Homo sapiens_hsa052191.06069601
77Adherens junction_Homo sapiens_hsa045201.05709019
78Pyruvate metabolism_Homo sapiens_hsa006201.04475856
79FoxO signaling pathway_Homo sapiens_hsa040681.04457839
80Endometrial cancer_Homo sapiens_hsa052131.04319701
81Hippo signaling pathway_Homo sapiens_hsa043901.04212294
82Biosynthesis of amino acids_Homo sapiens_hsa012300.99258827
83One carbon pool by folate_Homo sapiens_hsa006700.98460015
84Hedgehog signaling pathway_Homo sapiens_hsa043400.98080631
85Fat digestion and absorption_Homo sapiens_hsa049750.96550381
86Inositol phosphate metabolism_Homo sapiens_hsa005620.95844456
87Viral carcinogenesis_Homo sapiens_hsa052030.94908664
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94141660
89HTLV-I infection_Homo sapiens_hsa051660.94066549
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93866108
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89815996
92Arginine and proline metabolism_Homo sapiens_hsa003300.88222593
93Pathways in cancer_Homo sapiens_hsa052000.87543136
94Vitamin digestion and absorption_Homo sapiens_hsa049770.85752898
95Renal cell carcinoma_Homo sapiens_hsa052110.84925125
96mTOR signaling pathway_Homo sapiens_hsa041500.84820633
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84787894
98B cell receptor signaling pathway_Homo sapiens_hsa046620.84548602
99Acute myeloid leukemia_Homo sapiens_hsa052210.83889004
100Carbon metabolism_Homo sapiens_hsa012000.83534807
101Oocyte meiosis_Homo sapiens_hsa041140.83058615
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79875562
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78507640
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77423261
105Measles_Homo sapiens_hsa051620.77322307
106Vitamin B6 metabolism_Homo sapiens_hsa007500.75943518
107Melanogenesis_Homo sapiens_hsa049160.74745004
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69878794
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65863416
110Cyanoamino acid metabolism_Homo sapiens_hsa004600.63355768
111Herpes simplex infection_Homo sapiens_hsa051680.62287626
112Circadian rhythm_Homo sapiens_hsa047100.61763545
113Sulfur relay system_Homo sapiens_hsa041220.60118253
114Dorso-ventral axis formation_Homo sapiens_hsa043200.60045511
115Purine metabolism_Homo sapiens_hsa002300.58447054
116Pyrimidine metabolism_Homo sapiens_hsa002400.57613732
117Glutathione metabolism_Homo sapiens_hsa004800.57384816
118T cell receptor signaling pathway_Homo sapiens_hsa046600.56680604
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55711122
120Epstein-Barr virus infection_Homo sapiens_hsa051690.54028524
121Prolactin signaling pathway_Homo sapiens_hsa049170.52847741
122Glycerolipid metabolism_Homo sapiens_hsa005610.52694279
123Fatty acid biosynthesis_Homo sapiens_hsa000610.52514119
124ErbB signaling pathway_Homo sapiens_hsa040120.52276154
125Maturity onset diabetes of the young_Homo sapiens_hsa049500.51665726
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.50554359
127Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50497819
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47623755
129Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47068779
130Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45451170
131Apoptosis_Homo sapiens_hsa042100.45132154
132Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44383846
133Insulin signaling pathway_Homo sapiens_hsa049100.42309142
134HIF-1 signaling pathway_Homo sapiens_hsa040660.39851372
135Toxoplasmosis_Homo sapiens_hsa051450.39589864
136Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39186911
137Pentose phosphate pathway_Homo sapiens_hsa000300.37994109
138Insulin resistance_Homo sapiens_hsa049310.36697954
139cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33891479
140Prion diseases_Homo sapiens_hsa050200.33623768
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.33479425
142Influenza A_Homo sapiens_hsa051640.33409027
143Systemic lupus erythematosus_Homo sapiens_hsa053220.31212248
144Metabolic pathways_Homo sapiens_hsa011000.28745452
145Adipocytokine signaling pathway_Homo sapiens_hsa049200.27859430
146Legionellosis_Homo sapiens_hsa051340.27030529
147Choline metabolism in cancer_Homo sapiens_hsa052310.26493460
148RNA polymerase_Homo sapiens_hsa030200.26170328
149Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.13326692
150Malaria_Homo sapiens_hsa051440.10813650
151AMPK signaling pathway_Homo sapiens_hsa041520.10777249
152alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.09070427
153ECM-receptor interaction_Homo sapiens_hsa045120.09050619
154NF-kappa B signaling pathway_Homo sapiens_hsa040640.06262216
155Linoleic acid metabolism_Homo sapiens_hsa005910.05923058
156Small cell lung cancer_Homo sapiens_hsa052220.05014590
157Amoebiasis_Homo sapiens_hsa051460.03834282
158Galactose metabolism_Homo sapiens_hsa00052-0.1010613
159Toll-like receptor signaling pathway_Homo sapiens_hsa04620-0.1009679
160Notch signaling pathway_Homo sapiens_hsa04330-0.0952208
161Glucagon signaling pathway_Homo sapiens_hsa04922-0.0929250
162PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0862854
163Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.0848989
164MicroRNAs in cancer_Homo sapiens_hsa05206-0.0833533
165Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.0830809
166Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.0794669
167Proteoglycans in cancer_Homo sapiens_hsa05205-0.0761273
168TGF-beta signaling pathway_Homo sapiens_hsa04350-0.0717988
169Focal adhesion_Homo sapiens_hsa04510-0.0705621
170RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0699467
171Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.0694223
172Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0684374
173Prostate cancer_Homo sapiens_hsa05215-0.0591759
174Basal cell carcinoma_Homo sapiens_hsa05217-0.0338118
175Pertussis_Homo sapiens_hsa05133-0.0306923
176Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0285161
177Hepatitis C_Homo sapiens_hsa05160-0.0028170

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