PRKDC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.11124629
2nuclear pore organization (GO:0006999)5.71400217
3mitotic sister chromatid cohesion (GO:0007064)5.22100337
4mitotic sister chromatid segregation (GO:0000070)5.10975617
5protein localization to kinetochore (GO:0034501)4.84105872
6pore complex assembly (GO:0046931)4.68246539
7pre-miRNA processing (GO:0031054)4.62329548
8DNA unwinding involved in DNA replication (GO:0006268)4.46513239
9regulation of RNA export from nucleus (GO:0046831)4.43771984
10regulation of histone H3-K9 methylation (GO:0051570)4.25113918
11mitotic chromosome condensation (GO:0007076)4.21789815
12protein localization to chromosome, centromeric region (GO:0071459)4.05661739
13regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.01898980
14regulation of DNA endoreduplication (GO:0032875)4.01024174
15DNA geometric change (GO:0032392)3.99935647
16DNA duplex unwinding (GO:0032508)3.97627279
17negative regulation of DNA repair (GO:0045738)3.95097420
18negative regulation of histone methylation (GO:0031061)3.93515427
19translesion synthesis (GO:0019985)3.90875547
20chromosome condensation (GO:0030261)3.87242502
21heterochromatin organization (GO:0070828)3.86200514
22dosage compensation (GO:0007549)3.86112786
23regulation of nucleobase-containing compound transport (GO:0032239)3.78615121
24mitotic nuclear envelope disassembly (GO:0007077)3.76918369
25mitotic metaphase plate congression (GO:0007080)3.69649789
26histone mRNA catabolic process (GO:0071044)3.66384873
27determination of adult lifespan (GO:0008340)3.60411751
28positive regulation of chromosome segregation (GO:0051984)3.58213610
29IMP biosynthetic process (GO:0006188)3.54384474
30membrane disassembly (GO:0030397)3.53716790
31nuclear envelope disassembly (GO:0051081)3.53716790
32positive regulation of gamma-delta T cell activation (GO:0046645)3.53156203
33DNA packaging (GO:0006323)3.50657037
34establishment of integrated proviral latency (GO:0075713)3.50328569
35protein complex localization (GO:0031503)3.42265488
36regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.41448440
37DNA replication initiation (GO:0006270)3.40224194
38kinetochore organization (GO:0051383)3.40059651
39metaphase plate congression (GO:0051310)3.37645490
40regulation of histone H3-K27 methylation (GO:0061085)3.37302238
41regulation of chromosome segregation (GO:0051983)3.34146264
42negative regulation of DNA-dependent DNA replication (GO:2000104)3.31806006
43regulation of helicase activity (GO:0051095)3.30255874
44sister chromatid segregation (GO:0000819)3.30064557
45meiotic chromosome segregation (GO:0045132)3.26479353
46cellular protein complex localization (GO:0034629)3.24666666
47positive regulation of cell cycle checkpoint (GO:1901978)3.24545588
48DNA replication-dependent nucleosome organization (GO:0034723)3.23147337
49DNA replication-dependent nucleosome assembly (GO:0006335)3.23147337
50folic acid-containing compound biosynthetic process (GO:0009396)3.22878552
51protein export from nucleus (GO:0006611)3.21087799
52positive regulation of histone H3-K4 methylation (GO:0051571)3.20457845
53DNA conformation change (GO:0071103)3.20391557
54antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.20150869
55* non-recombinational repair (GO:0000726)3.19746370
56* double-strand break repair via nonhomologous end joining (GO:0006303)3.19746370
57chromatin assembly (GO:0031497)3.18646696
58spliceosomal tri-snRNP complex assembly (GO:0000244)3.18268857
59maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.17353944
60postreplication repair (GO:0006301)3.17298777
61negative T cell selection (GO:0043383)3.17172048
62DNA strand renaturation (GO:0000733)3.14628275
63histone H3-K9 methylation (GO:0051567)3.14470582
64negative regulation of chromosome segregation (GO:0051985)3.14343540
65protein localization to chromosome (GO:0034502)3.13891257
66negative thymic T cell selection (GO:0045060)3.13271279
67mitotic recombination (GO:0006312)3.12567953
68histone H3-K4 methylation (GO:0051568)3.11947667
69histone H3-K4 trimethylation (GO:0080182)3.11680715
70nucleotide-excision repair, DNA gap filling (GO:0006297)3.10496922
71DNA strand elongation involved in DNA replication (GO:0006271)3.09448469
72negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.09146136
73negative regulation of translation, ncRNA-mediated (GO:0040033)3.09146136
74regulation of translation, ncRNA-mediated (GO:0045974)3.09146136
75sister chromatid cohesion (GO:0007062)3.07890904
76chromosome segregation (GO:0007059)3.07717959
77paraxial mesoderm development (GO:0048339)3.06585916
78formation of translation preinitiation complex (GO:0001731)3.06136467
79regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.06123806
80positive regulation of histone methylation (GO:0031062)3.05283807
81DNA strand elongation (GO:0022616)3.05007853
82regulation of DNA damage checkpoint (GO:2000001)3.03998206
83spindle checkpoint (GO:0031577)3.03914646
84regulation of sister chromatid segregation (GO:0033045)3.02487702
85regulation of mitotic sister chromatid separation (GO:0010965)3.02487702
86regulation of mitotic sister chromatid segregation (GO:0033047)3.02487702
87negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.02357341
88histone H4-K16 acetylation (GO:0043984)3.00973691
89regulation of mitotic metaphase/anaphase transition (GO:0030071)3.00810517
90regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.00810517
91regulation of nuclear cell cycle DNA replication (GO:0033262)3.00802737
92peptidyl-lysine trimethylation (GO:0018023)3.00233745
93establishment of chromosome localization (GO:0051303)2.99473871
94ATP-dependent chromatin remodeling (GO:0043044)2.99269568
95mRNA transport (GO:0051028)2.99236973
96DNA ligation (GO:0006266)2.98566977
97chromatin assembly or disassembly (GO:0006333)2.98459442
98histone H4-K5 acetylation (GO:0043981)2.97646028
99histone H4-K8 acetylation (GO:0043982)2.97646028
100monoubiquitinated protein deubiquitination (GO:0035520)2.97622134
101chromatin remodeling at centromere (GO:0031055)2.96247095
102DNA replication checkpoint (GO:0000076)2.96115368
103negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.95601592
104negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.95601592
105negative regulation of mitotic sister chromatid segregation (GO:0033048)2.95601592
106negative regulation of mitotic sister chromatid separation (GO:2000816)2.95601592
107negative regulation of sister chromatid segregation (GO:0033046)2.95601592
108mitotic spindle checkpoint (GO:0071174)2.95253316
109DNA replication-independent nucleosome assembly (GO:0006336)2.94988975
110DNA replication-independent nucleosome organization (GO:0034724)2.94988975
111ribosome assembly (GO:0042255)2.94671956
112DNA synthesis involved in DNA repair (GO:0000731)2.94524536
113* telomere maintenance (GO:0000723)2.93565176
114regulation of histone methylation (GO:0031060)2.93249305
115IMP metabolic process (GO:0046040)2.92745321
116replication fork processing (GO:0031297)2.92519610
117* telomere organization (GO:0032200)2.92471188
118regulation of sister chromatid cohesion (GO:0007063)2.92088086
119replicative senescence (GO:0090399)2.91629886
120DNA topological change (GO:0006265)2.91188364
121mitotic spindle assembly checkpoint (GO:0007094)2.90372801
122regulation of protein polyubiquitination (GO:1902914)2.88847498
123positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.88752740
124positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.88752740
125positive regulation of mitotic sister chromatid separation (GO:1901970)2.88752740
126telomere maintenance via recombination (GO:0000722)2.88520636
127protein-DNA complex disassembly (GO:0032986)2.88165432
128nucleosome disassembly (GO:0006337)2.88165432
129CENP-A containing nucleosome assembly (GO:0034080)2.87862337
130regulation of spindle organization (GO:0090224)2.87209189
131regulation of mitotic spindle organization (GO:0060236)2.87023305
132regulation of centrosome duplication (GO:0010824)2.86727860
133spindle assembly checkpoint (GO:0071173)2.86306082
134regulation of centrosome cycle (GO:0046605)2.84833335
135mismatch repair (GO:0006298)2.83698797
136NLS-bearing protein import into nucleus (GO:0006607)2.83263612
137telomere maintenance via semi-conservative replication (GO:0032201)2.82124743
138negative regulation of DNA recombination (GO:0045910)2.81771668
139somatic hypermutation of immunoglobulin genes (GO:0016446)2.81175092
140somatic diversification of immune receptors via somatic mutation (GO:0002566)2.81175092
141DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.80831066
142regulation of centriole replication (GO:0046599)2.80445059
143histone H3-K9 modification (GO:0061647)2.79348644
144histone lysine methylation (GO:0034968)2.78373721
145histone H3-K36 demethylation (GO:0070544)2.76112809
146nuclear envelope organization (GO:0006998)2.75346991
147regulation of translational fidelity (GO:0006450)2.75003478

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.02831927
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.70290951
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.45736293
4* EGR1_19374776_ChIP-ChIP_THP-1_Human3.76858054
5KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.95549113
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.77135352
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.63812474
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.52445783
9MYC_22102868_ChIP-Seq_BL_Human2.49531296
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.42771863
11* E2F1_21310950_ChIP-Seq_MCF-7_Human2.37189296
12CIITA_25753668_ChIP-Seq_RAJI_Human2.21777501
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.13671850
14* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.04866377
15* E2F7_22180533_ChIP-Seq_HELA_Human11.8330273
16AR_21909140_ChIP-Seq_LNCAP_Human1.98863328
17IRF8_22096565_ChIP-ChIP_GC-B_Human1.89080523
18* MYC_18555785_ChIP-Seq_MESCs_Mouse1.84581155
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.80367012
20ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.78476026
21YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76670647
22NELFA_20434984_ChIP-Seq_ESCs_Mouse1.74930955
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.61375070
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.60080048
25GATA1_22025678_ChIP-Seq_K562_Human1.58710311
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.56437056
27THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55982576
28TTF2_22483619_ChIP-Seq_HELA_Human1.51426751
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49557845
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.49179596
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49168685
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.49047362
33* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.48535262
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.48448628
35SCL_19346495_ChIP-Seq_HPC-7_Human1.46495982
36DCP1A_22483619_ChIP-Seq_HELA_Human1.44632302
37VDR_21846776_ChIP-Seq_THP-1_Human1.43571536
38MYB_26560356_Chip-Seq_TH1_Human1.43450338
39MYB_26560356_Chip-Seq_TH2_Human1.43435824
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40905471
41* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39267752
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38398816
43SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.37228019
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.34152819
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33001438
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32536656
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32026660
48VDR_23849224_ChIP-Seq_CD4+_Human1.31993953
49* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.31421676
50* FOXP3_21729870_ChIP-Seq_TREG_Human1.30588015
51RUNX_20019798_ChIP-Seq_JUKART_Human1.30324873
52* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30304434
53ZNF263_19887448_ChIP-Seq_K562_Human1.29794383
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28701058
55CHD1_26751641_Chip-Seq_LNCaP_Human1.28318890
56* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27722443
57* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.26591718
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.26344866
59TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.26190207
60CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.24045655
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24041316
62* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23513877
63KDM5A_27292631_Chip-Seq_BREAST_Human1.23371033
64TCF7_22412390_ChIP-Seq_EML_Mouse1.20774081
65CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18634942
66UTX_26944678_Chip-Seq_JUKART_Human1.18513517
67HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16284486
68MAF_26560356_Chip-Seq_TH1_Human1.14462253
69* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12709624
70ELK1_19687146_ChIP-ChIP_HELA_Human1.11919991
71KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11680124
72FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11412692
73TFEB_21752829_ChIP-Seq_HELA_Human1.11001814
74NANOG_21062744_ChIP-ChIP_HESCs_Human1.09548092
75* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08198334
76SOX17_20123909_ChIP-Seq_XEN_Mouse1.07513925
77ETS1_20019798_ChIP-Seq_JURKAT_Human1.07291095
78HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06923285
79STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06654595
80* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06510436
81PKCTHETA_26484144_Chip-Seq_BREAST_Human1.06466352
82ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.06125965
83* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05591449
84SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.05245562
85XRN2_22483619_ChIP-Seq_HELA_Human1.04668581
86CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04319388
87SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03329069
88MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03035367
89EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.03009736
90* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.02358184
91TP63_19390658_ChIP-ChIP_HaCaT_Human1.01674561
92EST1_17652178_ChIP-ChIP_JURKAT_Human0.99480710
93NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97093330
94SPI1_23547873_ChIP-Seq_NB4_Human0.96560951
95* GABP_19822575_ChIP-Seq_HepG2_Human0.96130322
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95521686
97JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.95206204
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94717476
99BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94504627
100WT1_19549856_ChIP-ChIP_CCG9911_Human0.93878195
101GATA3_27048872_Chip-Seq_THYMUS_Human0.92759561
102CLOCK_20551151_ChIP-Seq_293T_Human0.92525070
103RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92420579
104SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.91551338
105* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.90865360
106STAT4_19710469_ChIP-ChIP_TH1__Mouse0.89258189
107ELF1_17652178_ChIP-ChIP_JURKAT_Human0.89107950
108TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88213313
109RUNX1_22412390_ChIP-Seq_EML_Mouse0.88015405
110SPI1_23127762_ChIP-Seq_K562_Human0.87078314
111NOTCH1_21737748_ChIP-Seq_TLL_Human0.86970724
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86839350
113STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86138004
114ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86065206
115DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85812083
116MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.84889816
117SOX2_18555785_ChIP-Seq_MESCs_Mouse0.84715040
118CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.84419792
119TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.83909007
120CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.81499259
121KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.81425141
122E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.80189363
123KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.79233467
124FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.78884400
125NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.78796851
126SOX2_16153702_ChIP-ChIP_HESCs_Human0.78759249
127TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.78227940
128* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.78028555
129NANOG_16153702_ChIP-ChIP_HESCs_Human0.77376605
130POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.76308389
131SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.75740684
132P300_27058665_Chip-Seq_ZR-75-30cells_Human0.75709303
133SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.75628157
134EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.75188585
135DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.74920084
136KLF4_18555785_ChIP-Seq_MESCs_Mouse0.74390476
137PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.74022165
138TP63_17297297_ChIP-ChIP_HaCaT_Human0.72861333
139* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.70939770
140* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.70661603

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.16322735
2MP0000569_abnormal_digit_pigmentation4.99279894
3MP0010094_abnormal_chromosome_stability4.29319288
4MP0003111_abnormal_nucleus_morphology3.44409850
5MP0003077_abnormal_cell_cycle3.18038523
6MP0002396_abnormal_hematopoietic_system3.17924303
7MP0010307_abnormal_tumor_latency2.98149446
8MP0003693_abnormal_embryo_hatching2.87174727
9MP0008058_abnormal_DNA_repair2.81706210
10MP0008877_abnormal_DNA_methylation2.72392277
11MP0003705_abnormal_hypodermis_morpholog2.52068235
12MP0004957_abnormal_blastocyst_morpholog2.40809842
13* MP0003763_abnormal_thymus_physiology2.30798321
14MP0008007_abnormal_cellular_replicative2.29403931
15MP0005076_abnormal_cell_differentiation2.22873355
16* MP0002166_altered_tumor_susceptibility2.21023276
17MP0004808_abnormal_hematopoietic_stem2.14251296
18MP0003787_abnormal_imprinting1.99896945
19MP0000537_abnormal_urethra_morphology1.94040682
20MP0010234_abnormal_vibrissa_follicle1.89001978
21MP0000350_abnormal_cell_proliferation1.86962541
22MP0003941_abnormal_skin_development1.86021264
23* MP0000703_abnormal_thymus_morphology1.81907495
24MP0001730_embryonic_growth_arrest1.81749080
25MP0005174_abnormal_tail_pigmentation1.80329628
26* MP0002006_tumorigenesis1.80175080
27* MP0002398_abnormal_bone_marrow1.78771710
28MP0004233_abnormal_muscle_weight1.76427070
29MP0004185_abnormal_adipocyte_glucose1.72924671
30MP0003121_genomic_imprinting1.72166023
31MP0000371_diluted_coat_color1.69791397
32MP0002697_abnormal_eye_size1.67228920
33* MP0001800_abnormal_humoral_immune1.62326689
34* MP0010352_gastrointestinal_tract_polyps1.60627135
35MP0003890_abnormal_embryonic-extraembry1.57629772
36MP0003937_abnormal_limbs/digits/tail_de1.55944297
37MP0003183_abnormal_peptide_metabolism1.52858258
38MP0001672_abnormal_embryogenesis/_devel1.51396735
39MP0005380_embryogenesis_phenotype1.51396735
40MP0002084_abnormal_developmental_patter1.46754128
41MP0003984_embryonic_growth_retardation1.44480466
42MP0002088_abnormal_embryonic_growth/wei1.41979402
43* MP0002722_abnormal_immune_system1.40963065
44MP0002086_abnormal_extraembryonic_tissu1.39352700
45* MP0000689_abnormal_spleen_morphology1.36853636
46MP0004197_abnormal_fetal_growth/weight/1.36444971
47MP0000015_abnormal_ear_pigmentation1.36206443
48MP0001697_abnormal_embryo_size1.35933172
49MP0005623_abnormal_meninges_morphology1.32975569
50* MP0001835_abnormal_antigen_presentation1.31846258
51* MP0002019_abnormal_tumor_incidence1.31266945
52* MP0000716_abnormal_immune_system1.30585210
53MP0003123_paternal_imprinting1.30064261
54MP0003300_gastrointestinal_ulcer1.29875536
55MP0008932_abnormal_embryonic_tissue1.27394610
56MP0002085_abnormal_embryonic_tissue1.26535721
57* MP0002420_abnormal_adaptive_immunity1.26325108
58MP0002095_abnormal_skin_pigmentation1.26268480
59MP0002075_abnormal_coat/hair_pigmentati1.22306905
60* MP0001819_abnormal_immune_cell1.21974955
61MP0009703_decreased_birth_body1.21506058
62MP0002080_prenatal_lethality1.21251595
63MP0003786_premature_aging1.20940774
64* MP0002452_abnormal_antigen_presenting1.17939788
65* MP0002429_abnormal_blood_cell1.17084530
66* MP0005671_abnormal_response_to1.13486036
67MP0001293_anophthalmia1.12237125
68MP0003385_abnormal_body_wall1.11314036
69MP0001286_abnormal_eye_development1.10567827
70MP0000685_abnormal_immune_system1.10053080
71MP0010030_abnormal_orbit_morphology1.09886849
72* MP0000313_abnormal_cell_death1.09473232
73MP0001346_abnormal_lacrimal_gland1.09033005
74MP0009278_abnormal_bone_marrow1.09018647
75MP0005397_hematopoietic_system_phenotyp1.08528164
76MP0001545_abnormal_hematopoietic_system1.08528164
77MP0004272_abnormal_basement_membrane1.06617842
78* MP0002723_abnormal_immune_serum1.05706745
79* MP0001873_stomach_inflammation1.03538711
80MP0003935_abnormal_craniofacial_develop1.00965771
81MP0003315_abnormal_perineum_morphology1.00033076
82MP0005409_darkened_coat_color0.99339585
83* MP0000490_abnormal_crypts_of0.99322706
84MP0000432_abnormal_head_morphology0.98621291
85MP0001299_abnormal_eye_distance/0.98402699
86MP0001849_ear_inflammation0.98161557
87MP0002210_abnormal_sex_determination0.96432393
88MP0002111_abnormal_tail_morphology0.95830296
89MP0009672_abnormal_birth_weight0.95506541
90MP0003943_abnormal_hepatobiliary_system0.95401439
91MP0005621_abnormal_cell_physiology0.95144777
92MP0000579_abnormal_nail_morphology0.95049941
93MP0003115_abnormal_respiratory_system0.94235623
94* MP0001929_abnormal_gametogenesis0.91739643
95MP0000427_abnormal_hair_cycle0.91059408
96MP0000733_abnormal_muscle_development0.90689371
97MP0003861_abnormal_nervous_system0.90074403
98* MP0001145_abnormal_male_reproductive0.89153153
99MP0000383_abnormal_hair_follicle0.88888108
100MP0005387_immune_system_phenotype0.87006102
101MP0001790_abnormal_immune_system0.87006102
102MP0003942_abnormal_urinary_system0.86229076
103MP0005075_abnormal_melanosome_morpholog0.85890463
104MP0005187_abnormal_penis_morphology0.85637736
105MP0001186_pigmentation_phenotype0.85379428
106MP0003567_abnormal_fetal_cardiomyocyte0.84783232
107MP0003718_maternal_effect0.83980483
108MP0004264_abnormal_extraembryonic_tissu0.83184767
109MP0003172_abnormal_lysosome_physiology0.83100510
110MP0002060_abnormal_skin_morphology0.82535772
111MP0008961_abnormal_basal_metabolism0.81271917
112MP0003221_abnormal_cardiomyocyte_apopto0.80426144
113MP0005501_abnormal_skin_physiology0.78972354
114* MP0005384_cellular_phenotype0.78558598
115MP0009053_abnormal_anal_canal0.78229159
116MP0000003_abnormal_adipose_tissue0.77923945
117MP0003045_fibrosis0.76750164
118MP0010678_abnormal_skin_adnexa0.75993041
119MP0002233_abnormal_nose_morphology0.75218388
120MP0010630_abnormal_cardiac_muscle0.75051856
121MP0000566_synostosis0.74995347
122MP0005451_abnormal_body_composition0.74770224
123MP0000762_abnormal_tongue_morphology0.74259864
124MP0002092_abnormal_eye_morphology0.73247483
125MP0003755_abnormal_palate_morphology0.72541328
126MP0002114_abnormal_axial_skeleton0.72054146
127MP0002081_perinatal_lethality0.71661823
128MP0000377_abnormal_hair_follicle0.71169356
129MP0000627_abnormal_mammary_gland0.70236915
130MP0003950_abnormal_plasma_membrane0.70080157
131* MP0000653_abnormal_sex_gland0.69273370
132MP0000428_abnormal_craniofacial_morphol0.69159886
133MP0002796_impaired_skin_barrier0.68367667
134* MP0005000_abnormal_immune_tolerance0.68121546
135* MP0002009_preneoplasia0.68043567
136MP0001853_heart_inflammation0.67660630
137MP0003566_abnormal_cell_adhesion0.67504559
138MP0002928_abnormal_bile_duct0.67094226
139MP0002925_abnormal_cardiovascular_devel0.66908206
140MP0008770_decreased_survivor_rate0.66845801
141MP0008995_early_reproductive_senescence0.66836163
142MP0006054_spinal_hemorrhage0.66092742
143MP0002877_abnormal_melanocyte_morpholog0.65837634
144MP0003453_abnormal_keratinocyte_physiol0.65199210
145MP0003091_abnormal_cell_migration0.65076241
146MP0008438_abnormal_cutaneous_collagen0.64431518
147MP0003119_abnormal_digestive_system0.64144322
148MP0002269_muscular_atrophy0.63595498
149* MP0002405_respiratory_system_inflammati0.63572131
150* MP0000358_abnormal_cell_content/0.63095304
151MP0001915_intracranial_hemorrhage0.62806047
152MP0009333_abnormal_splenocyte_physiolog0.60656300

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.48559811
2Abnormality of the fingertips (HP:0001211)4.34981866
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.21248377
4Volvulus (HP:0002580)4.17492856
5Abnormality of chromosome stability (HP:0003220)3.58586017
6Ectopic kidney (HP:0000086)3.46442192
7Ependymoma (HP:0002888)3.39532386
8Prominent nose (HP:0000448)3.21141507
9T lymphocytopenia (HP:0005403)3.16978803
10Astrocytoma (HP:0009592)3.07579814
11Abnormality of the astrocytes (HP:0100707)3.07579814
12Medulloblastoma (HP:0002885)3.05569451
13Abnormality of T cell number (HP:0011839)2.93072555
14Macroorchidism (HP:0000053)2.91299588
15Abnormality of DNA repair (HP:0003254)2.88292793
16Nephroblastoma (Wilms tumor) (HP:0002667)2.84124529
17Glioma (HP:0009733)2.81777770
18Selective tooth agenesis (HP:0001592)2.81385373
19Anal stenosis (HP:0002025)2.76274344
20Long eyelashes (HP:0000527)2.74527305
21Neoplasm of the oral cavity (HP:0100649)2.70405315
22Cortical dysplasia (HP:0002539)2.68661258
23Heterotopia (HP:0002282)2.68016300
24Aplasia/Hypoplasia of the uvula (HP:0010293)2.65431831
25Embryonal renal neoplasm (HP:0011794)2.65172125
26Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.60630598
27Short 4th metacarpal (HP:0010044)2.60630598
28Increased nuchal translucency (HP:0010880)2.51993117
29High anterior hairline (HP:0009890)2.49740316
30Rhabdomyosarcoma (HP:0002859)2.48943412
31Missing ribs (HP:0000921)2.45408032
32Truncal obesity (HP:0001956)2.44676092
33Obsessive-compulsive behavior (HP:0000722)2.43415830
34Ankyloglossia (HP:0010296)2.37303717
35Recurrent viral infections (HP:0004429)2.36675167
36Narrow palate (HP:0000189)2.36626856
37Birth length less than 3rd percentile (HP:0003561)2.35920559
38Urethral obstruction (HP:0000796)2.35290902
39Basal cell carcinoma (HP:0002671)2.34271180
40IgM deficiency (HP:0002850)2.33885914
41Abnormality of the carotid arteries (HP:0005344)2.32637119
42Trigonocephaly (HP:0000243)2.30386893
43Proximal placement of thumb (HP:0009623)2.30163147
44Papillary thyroid carcinoma (HP:0002895)2.29730455
45Cafe-au-lait spot (HP:0000957)2.29029500
46Hypoplasia of the thymus (HP:0000778)2.27188836
47Acute myeloid leukemia (HP:0004808)2.25980673
48Agnosia (HP:0010524)2.24249603
49Deviation of the thumb (HP:0009603)2.23118014
50Lymphoma (HP:0002665)2.22290145
51Abnormality of the preputium (HP:0100587)2.22022823
52Neoplasm of striated muscle (HP:0009728)2.21825682
53Colon cancer (HP:0003003)2.21627893
54Meckel diverticulum (HP:0002245)2.20862439
55Myelodysplasia (HP:0002863)2.17939563
56Abnormality of the calcaneus (HP:0008364)2.15015645
57Relative macrocephaly (HP:0004482)2.14448945
58Termporal pattern (HP:0011008)2.14304899
59Insidious onset (HP:0003587)2.14304899
60Abnormality of the ileum (HP:0001549)2.13519179
61High pitched voice (HP:0001620)2.12548578
62IgA deficiency (HP:0002720)2.11423071
63Abnormality of T cells (HP:0002843)2.11402960
64Low anterior hairline (HP:0000294)2.10883882
65Cellular immunodeficiency (HP:0005374)2.10730694
66Lymphopenia (HP:0001888)2.09436341
67Dysmetric saccades (HP:0000641)2.07653775
68Duplicated collecting system (HP:0000081)2.07451938
69Absent radius (HP:0003974)2.07093717
70Asymmetry of the thorax (HP:0001555)2.06646740
71Abnormality of cells of the lymphoid lineage (HP:0012140)2.04056671
72Clubbing of toes (HP:0100760)2.03721043
73Leukopenia (HP:0001882)2.03206834
74Abnormality of oral frenula (HP:0000190)2.01655477
75Impulsivity (HP:0100710)1.99917948
76Recurrent bronchitis (HP:0002837)1.98907647
77Abnormality of the distal phalanx of the thumb (HP:0009617)1.97195195
78Sandal gap (HP:0001852)1.92720984
79Insomnia (HP:0100785)1.92090301
80Duplication of thumb phalanx (HP:0009942)1.91891707
81Abnormality of chromosome segregation (HP:0002916)1.91804799
82Deep philtrum (HP:0002002)1.91656460
83Poikiloderma (HP:0001029)1.90832426
84Ulnar bowing (HP:0003031)1.90463247
85Abnormality of the nasal septum (HP:0000419)1.90033264
86Rib fusion (HP:0000902)1.89858307
87Bone marrow hypocellularity (HP:0005528)1.89602613
88Biliary tract neoplasm (HP:0100574)1.88681763
89Abnormal number of incisors (HP:0011064)1.88225670
90Acute lymphatic leukemia (HP:0006721)1.87673811
91Absent forearm bone (HP:0003953)1.87594296
92Aplasia involving forearm bones (HP:0009822)1.87594296
93Sloping forehead (HP:0000340)1.87137736
94Choanal atresia (HP:0000453)1.87017487
95Thyroiditis (HP:0100646)1.86994535
96Abnormality of the labia minora (HP:0012880)1.86335957
97Amaurosis fugax (HP:0100576)1.86283515
9811 pairs of ribs (HP:0000878)1.86133934
99Duodenal stenosis (HP:0100867)1.85903870
100Small intestinal stenosis (HP:0012848)1.85903870
101Cutis marmorata (HP:0000965)1.82000733
102Renovascular hypertension (HP:0100817)1.81944172
103Premature graying of hair (HP:0002216)1.81052238
104Aqueductal stenosis (HP:0002410)1.80025518
105Progressive external ophthalmoplegia (HP:0000590)1.79650921
106Absent frontal sinuses (HP:0002688)1.78922124
107Hyperacusis (HP:0010780)1.78910408
108Cerebral aneurysm (HP:0004944)1.77883147
109Overriding aorta (HP:0002623)1.77454330
110Multiple enchondromatosis (HP:0005701)1.76476607
111Malignant gastrointestinal tract tumors (HP:0006749)1.76385148
112Gastrointestinal carcinoma (HP:0002672)1.76385148
113Abnormality of cochlea (HP:0000375)1.75928070
114Microvesicular hepatic steatosis (HP:0001414)1.75298772
115Abnormality of the renal collecting system (HP:0004742)1.74838048
116Embryonal neoplasm (HP:0002898)1.73621674
117Chronic diarrhea (HP:0002028)1.73481918
118Elfin facies (HP:0004428)1.72853016
119Resting tremor (HP:0002322)1.72425376
120Sparse lateral eyebrow (HP:0005338)1.71914023
121Limited elbow extension (HP:0001377)1.71478839
122Recurrent fungal infections (HP:0002841)1.70955736
123Hypopigmentation of the fundus (HP:0007894)1.70468922
124Overlapping toe (HP:0001845)1.70367259
125Spinal cord lesions (HP:0100561)1.70115053
126Syringomyelia (HP:0003396)1.70115053
127Arteriovenous malformation (HP:0100026)1.69508476
128B lymphocytopenia (HP:0010976)1.69375305
129Abnormality of B cell number (HP:0010975)1.69375305
130Skull defect (HP:0001362)1.69109930
131Skin tags (HP:0010609)1.69092105
132Vertebral arch anomaly (HP:0008438)1.68804265
133Atresia of the external auditory canal (HP:0000413)1.68330000
134Subacute progressive viral hepatitis (HP:0006572)1.67973685
135Abnormal lung lobation (HP:0002101)1.67369483
136Absent thumb (HP:0009777)1.67305599
137Freckling (HP:0001480)1.66764627
138Abnormality of the duodenum (HP:0002246)1.66753815
139Renal duplication (HP:0000075)1.66584884
140Partial agenesis of the corpus callosum (HP:0001338)1.66512966
141Leiomyosarcoma (HP:0100243)1.66489893
142Uterine leiomyosarcoma (HP:0002891)1.66489893
143Facial cleft (HP:0002006)1.66341874
144Spastic diplegia (HP:0001264)1.64958117
145Abnormal foot bone ossification (HP:0010675)1.63922094
146Aplasia/Hypoplasia of the sternum (HP:0006714)1.62163541
147Reticulocytopenia (HP:0001896)1.61580575
148Abnormality of the phalanges of the hallux (HP:0010057)1.61354591
149Progressive muscle weakness (HP:0003323)1.60531645
150Septate vagina (HP:0001153)1.58448554

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.61032573
2CDC74.35849446
3BRD43.13778812
4BUB12.60434371
5MAP4K12.59712797
6SMG12.52523665
7CAMK1D2.47402645
8NEK22.24522823
9PBK2.18657930
10* ATR2.15639002
11ICK2.10793443
12SCYL22.01085747
13EEF2K1.88898352
14CAMK1G1.86362688
15PLK41.73037988
16EIF2AK11.72545204
17MST1R1.71800548
18TRIB31.71514355
19FGFR31.69247916
20WEE11.61397973
21TAF11.59360118
22STK101.58281569
23PASK1.55722393
24TYK21.53940857
25MAP3K101.51457330
26SRPK11.49918647
27TTK1.49526125
28ACVR1B1.47684703
29STK41.47475584
30CDK41.40531230
31CHEK11.39827097
32ITK1.38924078
33ZAK1.34751975
34PDGFRA1.31824359
35CDK91.31373850
36* ATM1.29807641
37DYRK31.28907954
38TXK1.27489683
39PIM11.26976755
40JAK31.26108474
41CDK61.24861359
42FGFR21.23584763
43MET1.22902025
44CDK71.20104647
45LATS21.16187349
46CHEK21.14833507
47TLK11.14202738
48FLT31.13618348
49CSF1R1.12362732
50PKN21.11627339
51MELK1.10313903
52MTOR1.09798724
53BRSK11.03749328
54FRK1.03344735
55JAK11.03295927
56PLK11.03070800
57GRK61.02822668
58* AURKB1.00455459
59CLK10.95637504
60STK30.95133031
61LATS10.94927210
62CDK20.94122410
63CDK80.92997917
64TSSK60.92306627
65RPS6KB20.86817796
66RIPK10.86203938
67TEC0.83142087
68ALK0.82947294
69RPS6KA40.79883339
70TTN0.79197584
71BTK0.79062198
72FGFR10.78750766
73CDK10.77767931
74LCK0.75916791
75FGFR40.75182679
76NEK10.74180407
77HCK0.71660224
78AURKA0.71527462
79IKBKE0.71393935
80MARK30.70184868
81EIF2AK20.70173141
82MKNK10.69785460
83NUAK10.68638469
84* PRKDC0.68319202
85ERBB40.68034122
86MAPK140.67516418
87MAP3K80.67028665
88SGK30.66280685
89PAK40.64753103
90CHUK0.64072202
91TESK20.64049684
92KIT0.63696625
93SGK20.62651701
94PLK30.62577637
95HIPK20.61971579
96MAP3K140.61940648
97PDGFRB0.61849372
98MKNK20.59569411
99* CSNK1D0.57403799
100PTK60.57347927
101PAK20.56035491
102NEK90.55161125
103BRSK20.54955180
104RPS6KB10.52872202
105CSNK1E0.51150327
106BRAF0.50027890
107AKT10.49272612
108SYK0.48865836
109TNK20.48566729
110MAPK100.48216012
111GSK3B0.47575087
112MAPK10.46822424
113NEK60.46747082
114ZAP700.46622188
115KSR20.46246974
116PNCK0.45554241
117IRAK30.44854502
118JAK20.44758910
119AKT20.42741999
120RAF10.42204951
121TRPM70.41607159
122KSR10.41369131
123EIF2AK30.41123027
124PTK20.40943591
125AKT30.40898498
126RPS6KA50.40779169
127CDK30.39224592
128CSK0.38345534
129VRK10.36534837
130MAPK110.36154969
131YES10.35667171
132STK38L0.35347107
133CSNK2A20.34481051
134WNK10.31726968
135NTRK10.31275523
136CDK150.28339769
137BMX0.28191222
138CDK180.27620334
139MAP3K90.27352873
140NME20.27044480

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.59113711
2Mismatch repair_Homo sapiens_hsa034303.20784594
3Fanconi anemia pathway_Homo sapiens_hsa034602.65917636
4* Cell cycle_Homo sapiens_hsa041102.63186809
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.32631722
6Homologous recombination_Homo sapiens_hsa034402.27985267
7Primary immunodeficiency_Homo sapiens_hsa053402.26676980
8RNA transport_Homo sapiens_hsa030132.24853904
9Base excision repair_Homo sapiens_hsa034102.20042690
10Systemic lupus erythematosus_Homo sapiens_hsa053222.13220650
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.13195864
12One carbon pool by folate_Homo sapiens_hsa006702.06565549
13* Non-homologous end-joining_Homo sapiens_hsa034502.06000198
14Spliceosome_Homo sapiens_hsa030401.89593536
15mRNA surveillance pathway_Homo sapiens_hsa030151.89127458
16Nucleotide excision repair_Homo sapiens_hsa034201.73954981
17Lysine degradation_Homo sapiens_hsa003101.71716112
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.54709428
19Viral carcinogenesis_Homo sapiens_hsa052031.53352568
20p53 signaling pathway_Homo sapiens_hsa041151.53262775
21RNA degradation_Homo sapiens_hsa030181.50028151
22Biosynthesis of amino acids_Homo sapiens_hsa012301.47873539
23Herpes simplex infection_Homo sapiens_hsa051681.47484059
24T cell receptor signaling pathway_Homo sapiens_hsa046601.41869955
25Antigen processing and presentation_Homo sapiens_hsa046121.40674407
26B cell receptor signaling pathway_Homo sapiens_hsa046621.39513257
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.29973145
28Transcriptional misregulation in cancer_Homo sapiens_hsa052021.28135868
29MicroRNAs in cancer_Homo sapiens_hsa052061.24329826
30HTLV-I infection_Homo sapiens_hsa051661.23090450
31Measles_Homo sapiens_hsa051621.22054210
32Small cell lung cancer_Homo sapiens_hsa052221.22027705
33Chronic myeloid leukemia_Homo sapiens_hsa052201.17148553
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16488194
35Thyroid hormone signaling pathway_Homo sapiens_hsa049191.15196338
36mTOR signaling pathway_Homo sapiens_hsa041501.14839881
37Colorectal cancer_Homo sapiens_hsa052101.13766726
38Notch signaling pathway_Homo sapiens_hsa043301.10721343
39Hematopoietic cell lineage_Homo sapiens_hsa046401.06136608
40Epstein-Barr virus infection_Homo sapiens_hsa051691.05673881
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.04759199
42Bladder cancer_Homo sapiens_hsa052191.01392226
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.01289984
44Alcoholism_Homo sapiens_hsa050341.01286827
45Selenocompound metabolism_Homo sapiens_hsa004500.98588269
46Hepatitis B_Homo sapiens_hsa051610.98171298
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98032590
48Vitamin B6 metabolism_Homo sapiens_hsa007500.96356307
49Hippo signaling pathway_Homo sapiens_hsa043900.96208054
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.93173761
51Basal transcription factors_Homo sapiens_hsa030220.91678738
52RNA polymerase_Homo sapiens_hsa030200.91546149
53Pentose phosphate pathway_Homo sapiens_hsa000300.91178533
54Inositol phosphate metabolism_Homo sapiens_hsa005620.90589825
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88168713
56Pancreatic cancer_Homo sapiens_hsa052120.87803990
57Intestinal immune network for IgA production_Homo sapiens_hsa046720.87337509
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86961665
59Non-small cell lung cancer_Homo sapiens_hsa052230.85282449
60Carbon metabolism_Homo sapiens_hsa012000.84738230
61Osteoclast differentiation_Homo sapiens_hsa043800.82105676
62Pyrimidine metabolism_Homo sapiens_hsa002400.79370518
63Oocyte meiosis_Homo sapiens_hsa041140.79144100
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78483089
65Apoptosis_Homo sapiens_hsa042100.78156568
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76427134
67Influenza A_Homo sapiens_hsa051640.75931493
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74519956
69Type II diabetes mellitus_Homo sapiens_hsa049300.73196320
70Pyruvate metabolism_Homo sapiens_hsa006200.73016095
71Viral myocarditis_Homo sapiens_hsa054160.72780683
72Prostate cancer_Homo sapiens_hsa052150.70920341
73ErbB signaling pathway_Homo sapiens_hsa040120.69051950
74Fatty acid biosynthesis_Homo sapiens_hsa000610.68984158
75Melanoma_Homo sapiens_hsa052180.68941365
76FoxO signaling pathway_Homo sapiens_hsa040680.68885898
77Renal cell carcinoma_Homo sapiens_hsa052110.68196899
78Dorso-ventral axis formation_Homo sapiens_hsa043200.68106116
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.67978190
80Adherens junction_Homo sapiens_hsa045200.67897497
81Acute myeloid leukemia_Homo sapiens_hsa052210.67496104
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67389361
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.63890416
84Leishmaniasis_Homo sapiens_hsa051400.63003600
85N-Glycan biosynthesis_Homo sapiens_hsa005100.60971096
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60633568
87Toxoplasmosis_Homo sapiens_hsa051450.59678925
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59505854
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59315236
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58038561
91Pathways in cancer_Homo sapiens_hsa052000.57770076
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.56829770
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56564000
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56314693
95Focal adhesion_Homo sapiens_hsa045100.56050881
96Endometrial cancer_Homo sapiens_hsa052130.54986411
97Hedgehog signaling pathway_Homo sapiens_hsa043400.54918394
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53335916
99Insulin resistance_Homo sapiens_hsa049310.53198685
100Insulin signaling pathway_Homo sapiens_hsa049100.52771484
101Tight junction_Homo sapiens_hsa045300.51589037
102Proteoglycans in cancer_Homo sapiens_hsa052050.50799880
103ECM-receptor interaction_Homo sapiens_hsa045120.50301615
104AMPK signaling pathway_Homo sapiens_hsa041520.50177872
105Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50174973
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49980553
107Platelet activation_Homo sapiens_hsa046110.49903566
108Basal cell carcinoma_Homo sapiens_hsa052170.49668128
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.49392413
110Thyroid cancer_Homo sapiens_hsa052160.48790446
111TGF-beta signaling pathway_Homo sapiens_hsa043500.46389237
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45596482
113Chemokine signaling pathway_Homo sapiens_hsa040620.45167616
114Purine metabolism_Homo sapiens_hsa002300.44288059
115TNF signaling pathway_Homo sapiens_hsa046680.42904669
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41599545
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40621932
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40042174
119Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39976878
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38761097
121Wnt signaling pathway_Homo sapiens_hsa043100.38638601
122Choline metabolism in cancer_Homo sapiens_hsa052310.37788593
123Glioma_Homo sapiens_hsa052140.37402078
124ABC transporters_Homo sapiens_hsa020100.36159055
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34482411
126Glucagon signaling pathway_Homo sapiens_hsa049220.34215089
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34143928
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31624059
129Steroid biosynthesis_Homo sapiens_hsa001000.31623557
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31310267
131HIF-1 signaling pathway_Homo sapiens_hsa040660.30462223
132Melanogenesis_Homo sapiens_hsa049160.30290243
133Thyroid hormone synthesis_Homo sapiens_hsa049180.28134769
134Arginine biosynthesis_Homo sapiens_hsa002200.27738343
135Estrogen signaling pathway_Homo sapiens_hsa049150.26058986

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