PRKG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skeletal muscle contraction (GO:0003009)5.58409478
2response to muscle activity (GO:0014850)4.97822969
3cardiac myofibril assembly (GO:0055003)4.72388383
4chondrocyte development (GO:0002063)4.55774535
5melanin biosynthetic process (GO:0042438)4.49722798
6muscle filament sliding (GO:0030049)4.46601794
7actin-myosin filament sliding (GO:0033275)4.46601794
8myotube cell development (GO:0014904)4.37653015
9plasma membrane repair (GO:0001778)4.37313259
10skeletal muscle fiber development (GO:0048741)4.23772743
11response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.18844937
12melanin metabolic process (GO:0006582)4.16348587
13collagen fibril organization (GO:0030199)4.13462783
14actin-mediated cell contraction (GO:0070252)4.10157758
15muscle cell cellular homeostasis (GO:0046716)4.04979045
16response to inactivity (GO:0014854)4.04025415
17myofibril assembly (GO:0030239)4.01081336
18muscle fiber development (GO:0048747)4.00136509
19* muscle system process (GO:0003012)3.96442706
20cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.68610198
21negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.63292841
22neuron projection extension involved in neuron projection guidance (GO:1902284)3.62334879
23axon extension involved in axon guidance (GO:0048846)3.62334879
24negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.61266460
25negative regulation of protein localization to cell surface (GO:2000009)3.60531766
26skeletal muscle tissue development (GO:0007519)3.57931442
27secondary metabolite biosynthetic process (GO:0044550)3.53589114
28* relaxation of muscle (GO:0090075)3.52885059
29negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.51182536
30skeletal muscle adaptation (GO:0043501)3.48040605
31regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.46306387
32regulation of relaxation of muscle (GO:1901077)3.45858498
33positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.41936879
34sequestering of extracellular ligand from receptor (GO:0035581)3.40397514
35regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.40377392
36muscle cell fate commitment (GO:0042693)3.39933642
37sarcomere organization (GO:0045214)3.36682356
38striated muscle adaptation (GO:0014888)3.35902762
39regulation of transforming growth factor beta2 production (GO:0032909)3.33629776
40actin filament-based movement (GO:0030048)3.33340701
41notochord development (GO:0030903)3.31389119
42regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.30630394
43muscle hypertrophy (GO:0014896)3.30425610
44striated muscle cell development (GO:0055002)3.29207785
45muscle structure development (GO:0061061)3.28712741
46peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.27585136
47muscle organ development (GO:0007517)3.27481533
48skeletal muscle tissue regeneration (GO:0043403)3.22496415
49negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.21338366
50negative regulation of calcium ion transmembrane transport (GO:1903170)3.21338366
51positive regulation of vasculogenesis (GO:2001214)3.19439103
52regulation of cell communication by electrical coupling (GO:0010649)3.18822279
53insulin-like growth factor receptor signaling pathway (GO:0048009)3.15594708
54cardiac muscle contraction (GO:0060048)3.10555296
55adult heart development (GO:0007512)3.07873558
56chondrocyte proliferation (GO:0035988)3.07117532
57regulation of myoblast differentiation (GO:0045661)3.06584698
58positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.05542350
59paraxial mesoderm development (GO:0048339)3.05495470
60regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.05395317
61positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.03239132
62mesenchymal cell differentiation involved in kidney development (GO:0072161)3.03051070
63mesenchymal cell differentiation involved in renal system development (GO:2001012)3.03051070
64neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.02473629
65cartilage condensation (GO:0001502)3.02162785
66cell aggregation (GO:0098743)3.02162785
67positive regulation of myoblast differentiation (GO:0045663)2.99211026
68cardiac muscle adaptation (GO:0014887)2.98385039
69cardiac muscle hypertrophy in response to stress (GO:0014898)2.98385039
70muscle hypertrophy in response to stress (GO:0003299)2.98385039
71muscle cell development (GO:0055001)2.98026043
72regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.97963170
73negative regulation of potassium ion transmembrane transport (GO:1901380)2.96534499
74actomyosin structure organization (GO:0031032)2.89700579
75mesenchymal-epithelial cell signaling (GO:0060638)2.89275995
76regulation of actin filament-based movement (GO:1903115)2.86513591
77* regulation of muscle system process (GO:0090257)2.85466698
78regulation of calcium ion transmembrane transport (GO:1903169)2.85303197
79regulation of calcium ion transmembrane transporter activity (GO:1901019)2.85303197
80cardiac muscle tissue morphogenesis (GO:0055008)2.83533560
81relaxation of cardiac muscle (GO:0055119)2.82563294
82regulation of sarcomere organization (GO:0060297)2.81839728
83endocardial cushion development (GO:0003197)2.80809257
84regulation of skeletal muscle contraction (GO:0014819)2.80790339
85regulation of cardioblast differentiation (GO:0051890)2.80481773
86striated muscle atrophy (GO:0014891)2.78523933
87negative regulation of striated muscle cell apoptotic process (GO:0010664)2.78043356
88myoblast fusion (GO:0007520)2.76478673
89striated muscle contraction (GO:0006941)2.74990573
90muscle tissue development (GO:0060537)2.71505855
91cardiac muscle hypertrophy (GO:0003300)2.70934017
92striated muscle tissue development (GO:0014706)2.70124685
93cardiac muscle cell development (GO:0055013)2.69657117
94regulation of the force of heart contraction (GO:0002026)2.69335061
95response to caffeine (GO:0031000)2.69144008
96* regulation of muscle contraction (GO:0006937)2.68296471
97regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.66251186
98positive regulation of fibroblast migration (GO:0010763)2.65469560
99pericardium development (GO:0060039)2.64491723
100muscle tissue morphogenesis (GO:0060415)2.64465197
101nucleus localization (GO:0051647)2.63373968
102extracellular fibril organization (GO:0043206)2.63241609
103nerve growth factor signaling pathway (GO:0038180)2.62282770
104regulation of axon extension involved in axon guidance (GO:0048841)2.61955496
105establishment of nucleus localization (GO:0040023)2.61794748
106regulation of vasculogenesis (GO:2001212)2.60613361
107regulation of axon guidance (GO:1902667)2.60403106
108negative regulation of hormone biosynthetic process (GO:0032353)2.59617659
109negative regulation of hormone metabolic process (GO:0032351)2.59617659
110metanephric mesenchyme development (GO:0072075)2.58936614
111smooth muscle tissue development (GO:0048745)2.58562048
112keratan sulfate catabolic process (GO:0042340)2.57819046
113positive regulation of muscle hypertrophy (GO:0014742)2.56503083
114positive regulation of cardiac muscle hypertrophy (GO:0010613)2.56503083
115heart morphogenesis (GO:0003007)2.56420613
116striated muscle hypertrophy (GO:0014897)2.56050106
117regulation of membrane repolarization (GO:0060306)2.54885428
118muscle atrophy (GO:0014889)2.54876976
119muscle adaptation (GO:0043500)2.54692034
120cardiac cell development (GO:0055006)2.54473189
121ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.53997354
122membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.52747689
123cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.52148584
124regulation of skeletal muscle fiber development (GO:0048742)2.51748880
125atrial septum morphogenesis (GO:0060413)2.51435535
126peripheral nervous system axon ensheathment (GO:0032292)2.50903403
127myelination in peripheral nervous system (GO:0022011)2.50903403
128creatine metabolic process (GO:0006600)2.50510242
129planar cell polarity pathway involved in neural tube closure (GO:0090179)2.50250055
130cellular response to dexamethasone stimulus (GO:0071549)2.49929985
131positive regulation of cardiac muscle cell differentiation (GO:2000727)2.49529468
132protein heterotrimerization (GO:0070208)2.48527338
133replacement ossification (GO:0036075)2.47179906
134endochondral ossification (GO:0001958)2.47179906
135bone trabecula formation (GO:0060346)2.46898970
136chondroitin sulfate biosynthetic process (GO:0030206)2.46766051
137cartilage morphogenesis (GO:0060536)2.45557463
138endocardial cushion morphogenesis (GO:0003203)2.44308115
139positive regulation of extracellular matrix organization (GO:1903055)2.43612325
140regulation of potassium ion transmembrane transporter activity (GO:1901016)2.41372824
141hippo signaling (GO:0035329)2.41297684
142regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.41191609
143glomerular filtration (GO:0003094)2.40809224
144sarcoplasmic reticulum calcium ion transport (GO:0070296)2.40551514
145negative regulation of dendrite morphogenesis (GO:0050774)2.40019061
146axonal fasciculation (GO:0007413)2.38043115
147cell migration involved in heart development (GO:0060973)2.36858507
148regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.35926886
149regulation of smooth muscle cell differentiation (GO:0051150)2.35516615
150negative regulation of smooth muscle cell differentiation (GO:0051151)2.32226851
151regulation of striated muscle contraction (GO:0006942)2.31570293
152regulation of cardioblast proliferation (GO:0003264)2.31075320
153regulation of secondary heart field cardioblast proliferation (GO:0003266)2.31075320
154cartilage development (GO:0051216)2.30513763
155syncytium formation by plasma membrane fusion (GO:0000768)2.29384731
156syncytium formation (GO:0006949)2.27933511
157muscle contraction (GO:0006936)2.27508603
158negative regulation of fatty acid transport (GO:2000192)2.26925008
159regulation of cardiac muscle hypertrophy (GO:0010611)2.26673763
160kidney mesenchyme development (GO:0072074)2.26576107
161glomerular basement membrane development (GO:0032836)2.25991425

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.27252483
2RBPJ_22232070_ChIP-Seq_NCS_Mouse2.93342327
3TRIM28_21343339_ChIP-Seq_HEK293_Human2.84212538
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.71899494
5RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.64312965
6EP300_21415370_ChIP-Seq_HL-1_Mouse2.60420379
7* GBX2_23144817_ChIP-Seq_PC3_Human2.60271293
8* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.40709335
9CDX2_19796622_ChIP-Seq_MESCs_Mouse2.32916995
10VDR_22108803_ChIP-Seq_LS180_Human2.19323324
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06667144
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95606569
13* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.93813798
14* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.93813798
15IGF1R_20145208_ChIP-Seq_DFB_Human1.92619603
16* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.91126235
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.90923084
18WT1_19549856_ChIP-ChIP_CCG9911_Human1.90494160
19PIAS1_25552417_ChIP-Seq_VCAP_Human1.89741463
20* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.89624020
21* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.87679803
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.87678762
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.83472219
24ZNF274_21170338_ChIP-Seq_K562_Hela1.81581284
25* SMAD4_21799915_ChIP-Seq_A2780_Human1.80170544
26ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.79108142
27* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.78372672
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.74980758
29CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.73267552
30* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71125679
31* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.70922145
32TP53_16413492_ChIP-PET_HCT116_Human1.68490692
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.67517118
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67264756
35P300_19829295_ChIP-Seq_ESCs_Human1.66643344
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65649766
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.63853911
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.63680183
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.63237728
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62945819
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.62577576
42AR_21572438_ChIP-Seq_LNCaP_Human1.61765093
43* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.61416531
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.60748815
45* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58595035
46CJUN_26792858_Chip-Seq_BT549_Human1.58228610
47* RNF2_27304074_Chip-Seq_ESCs_Mouse1.56515564
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.56371763
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.56155863
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55540896
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54745575
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51833852
53FUS_26573619_Chip-Seq_HEK293_Human1.50709726
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48540098
55TAF15_26573619_Chip-Seq_HEK293_Human1.47863320
56TP53_18474530_ChIP-ChIP_U2OS_Human1.47694223
57* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.47335120
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47246454
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.42330000
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.41684799
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41381494
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40030200
63* STAT3_23295773_ChIP-Seq_U87_Human1.39222015
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39019891
65HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.37832909
66BCAT_22108803_ChIP-Seq_LS180_Human1.37779484
67* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.37657333
68TCF4_18268006_ChIP-ChIP_LS174T_Human1.36087315
69* AR_25329375_ChIP-Seq_VCAP_Human1.34906748
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.34227507
71ISL1_27105846_Chip-Seq_CPCs_Mouse1.33856987
72* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.30778005
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30231226
74MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.28014269
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27029560
76* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24892633
77* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24892633
78EZH2_27294783_Chip-Seq_ESCs_Mouse1.24320545
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22641653
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22641653
81* SOX2_21211035_ChIP-Seq_LN229_Gbm1.22560984
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22481031
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.20196016
84* GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20132314
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.19543569
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18740958
87RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18405213
88BRD4_25478319_ChIP-Seq_HGPS_Human1.17744468
89BP1_19119308_ChIP-ChIP_Hs578T_Human1.16958261
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16840830
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16810699
92WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16008749
93TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.13643995
94* TCF4_23295773_ChIP-Seq_U87_Human1.12768366
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11664749
96PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11470142
97* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11387701
98KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11165891
99CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10970603
100AHR_22903824_ChIP-Seq_MCF-7_Human1.10967174
101SMAD3_21741376_ChIP-Seq_HESCs_Human1.10934805
102* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10634233
103CRX_20693478_ChIP-Seq_RETINA_Mouse1.09970889
104LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08794388
105* AR_19668381_ChIP-Seq_PC3_Human1.08403804
106CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08240328
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07825869
108CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07605983
109* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06953291
110TBX20_22328084_ChIP-Seq_HEART_Mouse1.05942404
111TBX20_22080862_ChIP-Seq_HEART_Mouse1.05942404
112RXR_22108803_ChIP-Seq_LS180_Human1.05507829
113* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05398528
114* EWS_26573619_Chip-Seq_HEK293_Human1.05301248
115DROSHA_22980978_ChIP-Seq_HELA_Human1.05221102
116FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04665358
117NANOG_18555785_Chip-Seq_ESCs_Mouse1.04083437
118PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03765523
119SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03452418
120RUNX2_22187159_ChIP-Seq_PCA_Human1.03107994
121ER_23166858_ChIP-Seq_MCF-7_Human1.02444255

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology3.98534150
2MP0008438_abnormal_cutaneous_collagen3.10089045
3MP0000372_irregular_coat_pigmentation3.01426780
4MP0000751_myopathy3.01397990
5MP0005171_absent_coat_pigmentation2.99349936
6MP0000749_muscle_degeneration2.78231104
7MP0004145_abnormal_muscle_electrophysio2.72116930
8MP0003646_muscle_fatigue2.67477807
9* MP0004084_abnormal_cardiac_muscle2.53814278
10MP0000569_abnormal_digit_pigmentation2.31700992
11MP0002837_dystrophic_cardiac_calcinosis2.30810824
12MP0009250_abnormal_appendicular_skeleto2.29623072
13* MP0004036_abnormal_muscle_relaxation2.07500477
14MP0005623_abnormal_meninges_morphology2.03623531
15MP0009384_cardiac_valve_regurgitation2.02112485
16MP0000013_abnormal_adipose_tissue2.00378245
17MP0005275_abnormal_skin_tensile1.97391550
18MP0004130_abnormal_muscle_cell1.96904572
19MP0003122_maternal_imprinting1.95296018
20MP0001299_abnormal_eye_distance/1.92470812
21MP0003279_aneurysm1.92097578
22MP0004215_abnormal_myocardial_fiber1.90916773
23MP0002282_abnormal_trachea_morphology1.84613481
24MP0004484_altered_response_of1.82454177
25MP0004134_abnormal_chest_morphology1.78287352
26MP0009780_abnormal_chondrocyte_physiolo1.77470622
27MP0004272_abnormal_basement_membrane1.71961034
28MP0003385_abnormal_body_wall1.69930321
29MP0002108_abnormal_muscle_morphology1.68864177
30MP0004233_abnormal_muscle_weight1.67083769
31* MP0005620_abnormal_muscle_contractility1.63491759
32MP0004087_abnormal_muscle_fiber1.60478781
33MP0002332_abnormal_exercise_endurance1.60325203
34MP0006138_congestive_heart_failure1.60223944
35MP0008775_abnormal_heart_ventricle1.55164118
36* MP0002972_abnormal_cardiac_muscle1.55049314
37MP0005508_abnormal_skeleton_morphology1.49213708
38MP0010386_abnormal_urinary_bladder1.47814103
39MP0002106_abnormal_muscle_physiology1.43881980
40MP0001968_abnormal_touch/_nociception1.43249630
41MP0005369_muscle_phenotype1.41476692
42MP0000747_muscle_weakness1.39987804
43MP0000733_abnormal_muscle_development1.38424160
44MP0000534_abnormal_ureter_morphology1.37400863
45MP0005257_abnormal_intraocular_pressure1.36468029
46MP0003123_paternal_imprinting1.36127425
47MP0002127_abnormal_cardiovascular_syste1.36018436
48MP0000163_abnormal_cartilage_morphology1.35294583
49MP0002735_abnormal_chemical_nociception1.34380146
50MP0001661_extended_life_span1.32173022
51MP0000759_abnormal_skeletal_muscle1.31221274
52MP0003121_genomic_imprinting1.30524191
53MP0002877_abnormal_melanocyte_morpholog1.29905868
54MP0000762_abnormal_tongue_morphology1.27895001
55MP0003942_abnormal_urinary_system1.27723727
56MP0002115_abnormal_skeleton_extremities1.27656564
57MP0001958_emphysema1.27524666
58MP0004085_abnormal_heartbeat1.25060504
59MP0005330_cardiomyopathy1.21495882
60MP0003705_abnormal_hypodermis_morpholog1.19741343
61MP0002109_abnormal_limb_morphology1.19652508
62MP0005408_hypopigmentation1.19409547
63MP0002933_joint_inflammation1.18952696
64MP0001270_distended_abdomen1.18926920
65MP0001879_abnormal_lymphatic_vessel1.18298216
66MP0002736_abnormal_nociception_after1.17859323
67MP0004270_analgesia1.16838718
68MP0010630_abnormal_cardiac_muscle1.15417442
69MP0002896_abnormal_bone_mineralization1.13256767
70MP0003137_abnormal_impulse_conducting1.13242878
71MP0003828_pulmonary_edema1.12505079
72MP0002269_muscular_atrophy1.12470485
73MP0003755_abnormal_palate_morphology1.12364610
74MP0006054_spinal_hemorrhage1.11522497
75MP0008004_abnormal_stomach_pH1.08810701
76MP0003091_abnormal_cell_migration1.08258564
77MP0002113_abnormal_skeleton_development1.07246003
78MP0010030_abnormal_orbit_morphology1.06632236
79MP0004859_abnormal_synaptic_plasticity1.06014489
80MP0003937_abnormal_limbs/digits/tail_de1.05714380
81MP0010368_abnormal_lymphatic_system1.05427366
82MP0006276_abnormal_autonomic_nervous1.05357662
83MP0000049_abnormal_middle_ear1.02264582
84* MP0005385_cardiovascular_system_phenoty1.01203396
85* MP0001544_abnormal_cardiovascular_syste1.01203396
86MP0003935_abnormal_craniofacial_develop0.99089585
87MP0002295_abnormal_pulmonary_circulatio0.97247513
88MP0004510_myositis0.95807918
89MP0000767_abnormal_smooth_muscle0.95082421
90MP0003787_abnormal_imprinting0.92874513
91MP0002932_abnormal_joint_morphology0.92800129
92MP0002249_abnormal_larynx_morphology0.92435010
93MP0002114_abnormal_axial_skeleton0.91539001
94* MP0005595_abnormal_vascular_smooth0.91052752
95MP0000750_abnormal_muscle_regeneration0.90868189
96MP0003566_abnormal_cell_adhesion0.90435119
97MP0003950_abnormal_plasma_membrane0.90210512
98MP0005248_abnormal_Harderian_gland0.88343717
99* MP0000230_abnormal_systemic_arterial0.88209764
100MP0001542_abnormal_bone_strength0.87396401
101MP0002116_abnormal_craniofacial_bone0.86812094
102MP0003045_fibrosis0.84154659
103MP0002128_abnormal_blood_circulation0.83309899
104MP0002938_white_spotting0.82971009
105MP0002089_abnormal_postnatal_growth/wei0.82226182
106MP0002734_abnormal_mechanical_nocicepti0.82205776
107MP0005023_abnormal_wound_healing0.81295525
108MP0000003_abnormal_adipose_tissue0.80350007
109MP0000432_abnormal_head_morphology0.78561714
110MP0003941_abnormal_skin_development0.78246730
111MP0002184_abnormal_innervation0.77605476
112MP0000266_abnormal_heart_morphology0.76387680
113MP0000371_diluted_coat_color0.74340624
114MP0000462_abnormal_digestive_system0.73548454
115MP0002233_abnormal_nose_morphology0.72818738
116MP0003879_abnormal_hair_cell0.71566380
117MP0005187_abnormal_penis_morphology0.69984221
118MP0000428_abnormal_craniofacial_morphol0.62557622
119MP0005670_abnormal_white_adipose0.59978758
120MP0001849_ear_inflammation0.56984592
121MP0001614_abnormal_blood_vessel0.53076438
122MP0005266_abnormal_metabolism0.52040604
123MP0005165_increased_susceptibility_to0.51734298
124MP0002102_abnormal_ear_morphology0.48200569
125MP0002925_abnormal_cardiovascular_devel0.47818420
126MP0005388_respiratory_system_phenotype0.47568958
127MP0002133_abnormal_respiratory_system0.47568958
128MP0002160_abnormal_reproductive_system0.45815293
129MP0002971_abnormal_brown_adipose0.45807539

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)4.95849500
2Hypoplastic ischia (HP:0003175)4.94562979
3Abnormality of the ischium (HP:0003174)4.47557730
4Irregular epiphyses (HP:0010582)4.41057469
5Vitreoretinal degeneration (HP:0000655)4.18712084
6Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.05632103
7Calcaneovalgus deformity (HP:0001848)3.94687641
8Protrusio acetabuli (HP:0003179)3.86270289
9Neck muscle weakness (HP:0000467)3.84539067
10Cupped ribs (HP:0000887)3.76889691
11Rimmed vacuoles (HP:0003805)3.61004753
12Deformed tarsal bones (HP:0008119)3.53283975
13Limited hip movement (HP:0008800)3.53219042
14Type 1 muscle fiber predominance (HP:0003803)3.43703203
15Myopathic facies (HP:0002058)3.37972102
16Small epiphyses (HP:0010585)3.27049745
17Neonatal short-limb short stature (HP:0008921)3.19467187
18Subaortic stenosis (HP:0001682)3.16676572
19Abnormality of the left ventricular outflow tract (HP:0011103)3.16676572
20Hip contracture (HP:0003273)3.16143373
21Centrally nucleated skeletal muscle fibers (HP:0003687)3.07901358
22Bundle branch block (HP:0011710)3.07391944
23Abnormality of the calf musculature (HP:0001430)3.04876709
24Myoglobinuria (HP:0002913)3.01524041
25Flat capital femoral epiphysis (HP:0003370)2.99755481
26Metaphyseal dysplasia (HP:0100255)2.97233246
27Slender build (HP:0001533)2.95969609
28Abnormal finger flexion creases (HP:0006143)2.95449284
29Areflexia of lower limbs (HP:0002522)2.92916203
30Mild short stature (HP:0003502)2.91757038
31Premature rupture of membranes (HP:0001788)2.87891979
32Difficulty running (HP:0009046)2.86355839
33Aortic dissection (HP:0002647)2.71361092
34Myotonia (HP:0002486)2.70909962
35Osteoarthritis (HP:0002758)2.68628678
36Distal arthrogryposis (HP:0005684)2.68615403
37Rhabdomyolysis (HP:0003201)2.65959836
38Muscle fiber splitting (HP:0003555)2.65878213
39Asymmetry of the thorax (HP:0001555)2.65503036
40Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.64263989
41Abnormality of femoral epiphyses (HP:0006499)2.64263989
42Calf muscle hypertrophy (HP:0008981)2.61883664
43* Aortic aneurysm (HP:0004942)2.59266596
44Exercise-induced muscle cramps (HP:0003710)2.59119006
45Asymmetric septal hypertrophy (HP:0001670)2.58353122
46Vascular tortuosity (HP:0004948)2.55639329
47Sudden death (HP:0001699)2.55402479
48Abnormality of the pubic bones (HP:0003172)2.55370789
49Metaphyseal cupping (HP:0003021)2.53514813
50Malignant hyperthermia (HP:0002047)2.52905595
51Delayed epiphyseal ossification (HP:0002663)2.52227321
52Hyporeflexia of lower limbs (HP:0002600)2.52031599
53Exercise-induced myalgia (HP:0003738)2.49288085
54Flat acetabular roof (HP:0003180)2.47260957
55Muscle stiffness (HP:0003552)2.46808681
56Muscle hypertrophy of the lower extremities (HP:0008968)2.46094572
57Atrial fibrillation (HP:0005110)2.45519426
58Abnormality of the epiphysis of the femoral head (HP:0010574)2.41860768
59Mesomelia (HP:0003027)2.40109419
60Broad ribs (HP:0000885)2.39729012
61Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.39480788
62Dilated cardiomyopathy (HP:0001644)2.38408719
63Frequent falls (HP:0002359)2.38231645
64Abnormal tarsal ossification (HP:0008369)2.37979228
65Gowers sign (HP:0003391)2.37134461
66Generalized muscle weakness (HP:0003324)2.36458592
67Arterial tortuosity (HP:0005116)2.36422763
68Ventricular tachycardia (HP:0004756)2.36355911
69Muscle fiber inclusion bodies (HP:0100299)2.34483995
70Muscular dystrophy (HP:0003560)2.29150030
71Primary atrial arrhythmia (HP:0001692)2.28168469
72Waddling gait (HP:0002515)2.25143174
73Abnormal foot bone ossification (HP:0010675)2.24562264
74Absent frontal sinuses (HP:0002688)2.21860343
75Popliteal pterygium (HP:0009756)2.20811267
76Coxa vara (HP:0002812)2.20515537
77Fetal akinesia sequence (HP:0001989)2.18870718
78Abnormality of the shoulder girdle musculature (HP:0001435)2.17842193
79Abnormality of the femoral head (HP:0003368)2.16772799
80Fibular aplasia (HP:0002990)2.15667457
81Abnormality of the calcaneus (HP:0008364)2.14518633
82Nemaline bodies (HP:0003798)2.13693726
83Supraventricular tachycardia (HP:0004755)2.11966068
84Lumbar hyperlordosis (HP:0002938)2.11656522
85EMG: neuropathic changes (HP:0003445)2.11639888
86Ulnar deviation of the wrist (HP:0003049)2.11151326
87Supraventricular arrhythmia (HP:0005115)2.10074080
88Weak cry (HP:0001612)2.09379308
89Exostoses (HP:0100777)2.06785818
90Spondylolisthesis (HP:0003302)2.05528482
91Cervical subluxation (HP:0003308)2.05178397
92Abnormality of the vertebral endplates (HP:0005106)2.05108795
93Abnormality of dentin (HP:0010299)2.03948808
94Genu varum (HP:0002970)2.03736769
95Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.03512527
96Increased connective tissue (HP:0009025)2.00758080
97Ovoid vertebral bodies (HP:0003300)2.00450809
98Abnormality of the neuromuscular junction (HP:0003398)2.00019812
99Fatigable weakness (HP:0003473)2.00019812
100Spinal rigidity (HP:0003306)1.99784547
101Limb-girdle muscle atrophy (HP:0003797)1.98017286
102Scapular winging (HP:0003691)1.97680685
103EMG: myopathic abnormalities (HP:0003458)1.97357030
104Proximal amyotrophy (HP:0007126)1.96921220
105Short femoral neck (HP:0100864)1.96511458
106Mitral valve prolapse (HP:0001634)1.96268759
107Limb-girdle muscle weakness (HP:0003325)1.95313868
108Delayed closure of the anterior fontanelle (HP:0001476)1.94814765
109Broad long bones (HP:0005622)1.93788568
110Ankle contracture (HP:0006466)1.93616400
111Flattened epiphyses (HP:0003071)1.93390221
112Knee flexion contracture (HP:0006380)1.93132872
113Irregular vertebral endplates (HP:0003301)1.92651938
114Lipoatrophy (HP:0100578)1.90767055
115Bulbar palsy (HP:0001283)1.89881265
116Bell-shaped thorax (HP:0001591)1.89814357
117Abnormality of incisor morphology (HP:0011063)1.89654806
118Limited elbow extension (HP:0001377)1.89517829
119Broad phalanx (HP:0006009)1.89269751
120Breech presentation (HP:0001623)1.87882680
121Absent epiphyses (HP:0010577)1.87698193
122Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.87698193
123Bladder diverticulum (HP:0000015)1.87174152
124Broad metatarsal (HP:0001783)1.86507567
125Hepatoblastoma (HP:0002884)1.85761558
126Increased variability in muscle fiber diameter (HP:0003557)1.83423087
127Distal lower limb muscle weakness (HP:0009053)1.81595609
128Round ear (HP:0100830)1.81260756
129Micromelia (HP:0002983)1.80928760
130Wormian bones (HP:0002645)1.80846418
131Steppage gait (HP:0003376)1.80805847
132Mildly elevated creatine phosphokinase (HP:0008180)1.80592004
133Blue irides (HP:0000635)1.80327064
134Type 2 muscle fiber atrophy (HP:0003554)1.80020414
135Heart block (HP:0012722)1.79980562
136Platyspondyly (HP:0000926)1.79544986
137Respiratory insufficiency due to muscle weakness (HP:0002747)1.79408399
138Absent phalangeal crease (HP:0006109)1.77670723
139Spinal cord compression (HP:0002176)1.76628571
140Distal lower limb amyotrophy (HP:0008944)1.76392994
141Abnormal vertebral ossification (HP:0100569)1.74454563
142Abnormality of the phalanges of the 2nd finger (HP:0009541)1.72918333
143Abnormal atrioventricular conduction (HP:0005150)1.72614727
144Soft skin (HP:0000977)1.72604206
145Abnormality of skeletal muscle fiber size (HP:0012084)1.72362825
146Overgrowth (HP:0001548)1.71697210
147Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.71664667
148Fibular hypoplasia (HP:0003038)1.70651646
149Facial diplegia (HP:0001349)1.68702443
150Metatarsus adductus (HP:0001840)1.68386894
151Hyperkalemia (HP:0002153)1.66813717
152Ulnar deviation of finger (HP:0009465)1.62369199
153Abnormality of the musculature of the pelvis (HP:0001469)1.61709666
154Abnormality of the hip-girdle musculature (HP:0001445)1.61709666
155Aplasia of the musculature (HP:0100854)1.60602766
156Delayed gross motor development (HP:0002194)1.58409002
157Lower limb amyotrophy (HP:0007210)1.58253453

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.88951833
2PINK13.95278797
3LATS13.67901499
4STK243.09154044
5DDR23.08133117
6STK38L3.05541536
7EPHA32.81948612
8PIK3CA2.78006743
9LATS22.23740932
10TTN2.11326000
11DMPK2.03379305
12MYLK2.00360059
13STK31.78274573
14NTRK31.66775825
15KSR11.62880195
16ZAK1.56029783
17PLK21.55658717
18MST1R1.53054375
19PRKD31.52405304
20MAP3K41.47312471
21NUAK11.43427097
22PTK2B1.43392540
23PKN21.42406374
24MINK11.37223813
25MUSK1.35000449
26SIK31.29961710
27CDC42BPA1.19079794
28PHKG21.13511154
29PHKG11.13511154
30STK381.11821407
31NTRK11.10992584
32GRK51.08353289
33PBK1.06869079
34CDK81.05560393
35EPHB21.05432484
36TNIK1.04724523
37PAK31.03977744
38SGK31.03688352
39ROCK11.03550526
40LMTK21.03410764
41SGK21.03006459
42MELK0.99722553
43FER0.99367335
44SIK10.99176827
45TRPM70.99119584
46PDGFRA0.96932951
47TAF10.94421577
48KSR20.94289867
49PIK3CG0.94005129
50RET0.93023951
51CAMK2G0.91932379
52MAP2K40.89190463
53WNK10.85557011
54MAPK130.84290234
55MET0.84103751
56MAP2K70.83334850
57MAP3K100.82078068
58TIE10.80962786
59PAK60.80253396
60FGFR30.77957730
61FRK0.76423509
62MAPK70.74926931
63NEK90.74639830
64MAPKAPK30.73221486
65MAP3K70.72198484
66TAOK10.72190848
67MAP3K90.71705405
68FGFR10.68549618
69NEK60.68258598
70ERBB30.66627678
71MARK30.65857432
72MAPKAPK50.64695079
73EEF2K0.63582697
74MAP3K60.62368718
75SGK2230.61780120
76SGK4940.61780120
77NEK10.61464353
78MOS0.60853671
79CDK90.60569199
80RIPK10.59877831
81RAF10.59313763
82NLK0.58472428
83CAMK2B0.56539881
84VRK10.55720550
85CAMK2A0.54100229
86MARK10.53715531
87PNCK0.53649287
88EPHA40.53319148
89TRIB30.52876204
90MAPK120.52785698
91PAK20.52053185
92DAPK30.51924993
93PKN10.50958180
94BCR0.50533623
95PDK30.50529289
96PDK40.50529289
97MAPK40.49585977
98PRKCE0.48397632
99AKT20.48172103
100WNK40.48020028
101PTK20.47998229
102CASK0.47081864
103AKT30.45779572
104CAMKK20.45718049
105STK390.45298918
106MAP3K30.44799547
107CSNK1G10.44604454
108CAMK2D0.44386718
109PDGFRB0.44154048
110ILK0.42968818
111* PRKG10.42524057
112PDK10.42300690
113PRKAA10.41595298
114ARAF0.40808925
115CCNB10.40063128
116TGFBR10.39461412
117LIMK10.38802028
118MAP2K10.38793913
119IGF1R0.38688501
120PRKACA0.38049594
121PRKAA20.37121485
122SGK10.36862117
123CSNK1G20.36638289
124HIPK20.36018952
125ADRBK10.35967568
126MAP3K50.35326798
127PAK10.34824604
128ICK0.33767751
129CAMK10.33550161
130BMX0.31723461
131TGFBR20.31572428
132BMPR1B0.31372782
133CAMK40.29488611
134STK110.29322307
135RPS6KA30.29176853
136CSNK1G30.28672956
137PRKACB0.28248335
138PRKD10.27914497
139NEK20.27358153
140BRSK20.27183567
141PRKACG0.24458210
142ROCK20.24448444
143PLK40.21971628

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.79052040
2Dilated cardiomyopathy_Homo sapiens_hsa054142.75115187
3ECM-receptor interaction_Homo sapiens_hsa045122.73437949
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.62098569
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.07923724
6Focal adhesion_Homo sapiens_hsa045102.03721419
7Cardiac muscle contraction_Homo sapiens_hsa042602.01706732
8Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.84805413
9Nitrogen metabolism_Homo sapiens_hsa009101.77118129
10Protein digestion and absorption_Homo sapiens_hsa049741.71233816
11* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.66812546
12Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.64873208
13Oxytocin signaling pathway_Homo sapiens_hsa049211.61405354
14* Circadian entrainment_Homo sapiens_hsa047131.54938947
15Melanogenesis_Homo sapiens_hsa049161.54360235
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.48382810
17Long-term potentiation_Homo sapiens_hsa047201.40068705
18Renin secretion_Homo sapiens_hsa049241.37897586
19Calcium signaling pathway_Homo sapiens_hsa040201.37555367
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.35740196
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33839524
22* Vascular smooth muscle contraction_Homo sapiens_hsa042701.32574301
23TGF-beta signaling pathway_Homo sapiens_hsa043501.28197740
24Insulin secretion_Homo sapiens_hsa049111.25468373
25Nicotine addiction_Homo sapiens_hsa050331.24486697
26Hippo signaling pathway_Homo sapiens_hsa043901.22787229
27Proteoglycans in cancer_Homo sapiens_hsa052051.21800527
28Central carbon metabolism in cancer_Homo sapiens_hsa052301.20692363
29GnRH signaling pathway_Homo sapiens_hsa049121.20679383
30Axon guidance_Homo sapiens_hsa043601.20674977
31Amphetamine addiction_Homo sapiens_hsa050311.20599665
32* Olfactory transduction_Homo sapiens_hsa047401.16794484
33Cholinergic synapse_Homo sapiens_hsa047251.15509237
34Glioma_Homo sapiens_hsa052141.13987876
35Glucagon signaling pathway_Homo sapiens_hsa049221.13787402
36* Salivary secretion_Homo sapiens_hsa049701.13747081
37Dopaminergic synapse_Homo sapiens_hsa047281.13718495
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.13242396
39Adherens junction_Homo sapiens_hsa045201.13174283
40Wnt signaling pathway_Homo sapiens_hsa043101.12852486
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12537715
42cAMP signaling pathway_Homo sapiens_hsa040241.10196977
43Pancreatic secretion_Homo sapiens_hsa049721.08193147
44PI3K-Akt signaling pathway_Homo sapiens_hsa041511.05408975
45Glutamatergic synapse_Homo sapiens_hsa047241.05368267
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04375051
47* Long-term depression_Homo sapiens_hsa047301.03929659
48Dorso-ventral axis formation_Homo sapiens_hsa043201.03674220
49Taste transduction_Homo sapiens_hsa047421.01247558
50Basal cell carcinoma_Homo sapiens_hsa052171.00741092
51Ovarian steroidogenesis_Homo sapiens_hsa049130.99901246
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99265355
53Melanoma_Homo sapiens_hsa052180.98784151
54Serotonergic synapse_Homo sapiens_hsa047260.98123914
55Type II diabetes mellitus_Homo sapiens_hsa049300.97088018
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96165256
57Estrogen signaling pathway_Homo sapiens_hsa049150.95461481
58MicroRNAs in cancer_Homo sapiens_hsa052060.95323229
59* Platelet activation_Homo sapiens_hsa046110.94992394
60mTOR signaling pathway_Homo sapiens_hsa041500.94204284
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93586836
62* Gap junction_Homo sapiens_hsa045400.91482405
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90952065
64HIF-1 signaling pathway_Homo sapiens_hsa040660.90204473
65Arginine and proline metabolism_Homo sapiens_hsa003300.89678991
66Colorectal cancer_Homo sapiens_hsa052100.89275743
67Gastric acid secretion_Homo sapiens_hsa049710.88180500
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87563947
69Morphine addiction_Homo sapiens_hsa050320.87008523
70Circadian rhythm_Homo sapiens_hsa047100.84984718
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84877044
72Oocyte meiosis_Homo sapiens_hsa041140.84698564
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83006587
74Renal cell carcinoma_Homo sapiens_hsa052110.82453131
75Rap1 signaling pathway_Homo sapiens_hsa040150.82122176
76GABAergic synapse_Homo sapiens_hsa047270.80018287
77ErbB signaling pathway_Homo sapiens_hsa040120.79603476
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.79263636
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79188704
80Propanoate metabolism_Homo sapiens_hsa006400.78906676
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78835953
82VEGF signaling pathway_Homo sapiens_hsa043700.78827918
83Hedgehog signaling pathway_Homo sapiens_hsa043400.78331155
84MAPK signaling pathway_Homo sapiens_hsa040100.77430225
85* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77022274
86Tight junction_Homo sapiens_hsa045300.76744039
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75613370
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75598263
89Thyroid hormone synthesis_Homo sapiens_hsa049180.75521841
90Amoebiasis_Homo sapiens_hsa051460.75513795
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75312591
92Choline metabolism in cancer_Homo sapiens_hsa052310.74858808
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74832310
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.72315165
95Insulin signaling pathway_Homo sapiens_hsa049100.72079364
96Ras signaling pathway_Homo sapiens_hsa040140.71772166
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71626531
98Synaptic vesicle cycle_Homo sapiens_hsa047210.71564489
99Pancreatic cancer_Homo sapiens_hsa052120.70353967
100Pentose phosphate pathway_Homo sapiens_hsa000300.68827767
101Arginine biosynthesis_Homo sapiens_hsa002200.68676012
102Endometrial cancer_Homo sapiens_hsa052130.68222722
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68132989
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66597102
105Alzheimers disease_Homo sapiens_hsa050100.66182187
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65091872
107FoxO signaling pathway_Homo sapiens_hsa040680.62992549
108Insulin resistance_Homo sapiens_hsa049310.62729700
109Pathways in cancer_Homo sapiens_hsa052000.61832560
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60638416
111AMPK signaling pathway_Homo sapiens_hsa041520.60489731
112Cocaine addiction_Homo sapiens_hsa050300.58862066
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58241176
114Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56434982
115Carbon metabolism_Homo sapiens_hsa012000.53481246
116Small cell lung cancer_Homo sapiens_hsa052220.52941054
117Fatty acid degradation_Homo sapiens_hsa000710.52673696
118Starch and sucrose metabolism_Homo sapiens_hsa005000.52191252
119Parkinsons disease_Homo sapiens_hsa050120.44352510
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44187471
121Bile secretion_Homo sapiens_hsa049760.41239084
122Pyruvate metabolism_Homo sapiens_hsa006200.40685125
123Renin-angiotensin system_Homo sapiens_hsa046140.38233227
124ABC transporters_Homo sapiens_hsa020100.32572892

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