PRKG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein plays a role in the regulation of fluid balance in the intestine. A similar protein in mouse is thought to regulate differentiation and proliferation of cells in the colon. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cartilage development involved in endochondral bone morphogenesis (GO:0060351)8.37044699
2drinking behavior (GO:0042756)8.36542600
3cartilage condensation (GO:0001502)7.38073864
4cell aggregation (GO:0098743)7.38073864
5negative regulation of digestive system process (GO:0060457)6.63396827
6chondrocyte development (GO:0002063)6.58953152
7limb bud formation (GO:0060174)5.98291434
8chondrocyte proliferation (GO:0035988)5.93554856
9notochord development (GO:0030903)5.90298536
10aggressive behavior (GO:0002118)5.80420600
11definitive hemopoiesis (GO:0060216)5.72338803
12positive regulation of vascular permeability (GO:0043117)5.70173735
13collagen fibril organization (GO:0030199)5.65660920
14negative regulation of appetite (GO:0032099)5.45071066
15negative regulation of response to food (GO:0032096)5.45071066
16embryonic skeletal joint morphogenesis (GO:0060272)5.37158388
17sphingomyelin metabolic process (GO:0006684)5.16950556
18keratan sulfate catabolic process (GO:0042340)5.15228959
19hormone catabolic process (GO:0042447)5.13447405
20negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)4.98265147
21positive regulation of extracellular matrix organization (GO:1903055)4.87146880
22regulation of metalloenzyme activity (GO:0048552)4.75630197
23cartilage development (GO:0051216)4.46333838
24regulation of appetite (GO:0032098)4.35486118
25photoreceptor cell maintenance (GO:0045494)4.33284263
26keratan sulfate biosynthetic process (GO:0018146)4.33256997
27nucleotide-sugar biosynthetic process (GO:0009226)4.28136018
28positive regulation of vasculogenesis (GO:2001214)4.28134817
29chondroitin sulfate biosynthetic process (GO:0030206)4.26491319
30peptide catabolic process (GO:0043171)4.23939099
31facial nerve structural organization (GO:0021612)4.17520672
32thrombin receptor signaling pathway (GO:0070493)4.11906491
33proteoglycan metabolic process (GO:0006029)4.02592340
34negative regulation of necrotic cell death (GO:0060547)4.00011535
35endothelium development (GO:0003158)3.99989830
36negative regulation of cell size (GO:0045792)3.97999907
37regulation of female receptivity (GO:0045924)3.97173831
38response to pheromone (GO:0019236)3.95608655
39oligosaccharide catabolic process (GO:0009313)3.94026747
40interkinetic nuclear migration (GO:0022027)3.91708346
41carnitine transmembrane transport (GO:1902603)3.89866859
42regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.88037365
43grooming behavior (GO:0007625)3.81169723
44positive regulation of chondrocyte differentiation (GO:0032332)3.78970600
45epithelial cell differentiation involved in kidney development (GO:0035850)3.76222532
46amino-acid betaine transport (GO:0015838)3.75609146
47carnitine transport (GO:0015879)3.75609146
48regulation of Golgi to plasma membrane protein transport (GO:0042996)3.70110920
49seminiferous tubule development (GO:0072520)3.68195469
50positive regulation of cartilage development (GO:0061036)3.66269317
51dermatan sulfate biosynthetic process (GO:0030208)3.64501265
52regulation of feeding behavior (GO:0060259)3.59451133
53regulation of endocrine process (GO:0044060)3.57720368
54cellular response to exogenous dsRNA (GO:0071360)3.55359660
55chondrocyte differentiation (GO:0002062)3.54529973
56collagen catabolic process (GO:0030574)3.52966206
57response to BMP (GO:0071772)3.50160965
58cellular response to BMP stimulus (GO:0071773)3.50160965
59multicellular organismal catabolic process (GO:0044243)3.49023583
60dermatan sulfate metabolic process (GO:0030205)3.48579904
61cGMP biosynthetic process (GO:0006182)3.47402457
62endochondral ossification (GO:0001958)3.46288241
63replacement ossification (GO:0036075)3.46288241
64cellular response to ATP (GO:0071318)3.45492210
65skeletal system development (GO:0001501)3.45490879
66protein retention in ER lumen (GO:0006621)3.45328890
67regulation of male gonad development (GO:2000018)3.45069596
68female mating behavior (GO:0060180)3.43467104
69collagen metabolic process (GO:0032963)3.43453854
70ribosomal small subunit assembly (GO:0000028)3.42109240
71response to nitrosative stress (GO:0051409)3.41774423
72forebrain morphogenesis (GO:0048853)3.40023505
73positive regulation of B cell differentiation (GO:0045579)3.39381084
74nucleotide-sugar metabolic process (GO:0009225)3.38901457
75keratan sulfate metabolic process (GO:0042339)3.36240734
76coenzyme catabolic process (GO:0009109)3.35593060
77multicellular organismal macromolecule metabolic process (GO:0044259)3.32681163
78UDP-N-acetylglucosamine metabolic process (GO:0006047)3.31530678
79regulation of response to food (GO:0032095)3.31521222
80detection of light stimulus involved in visual perception (GO:0050908)3.29555738
81detection of light stimulus involved in sensory perception (GO:0050962)3.29555738
82aldehyde catabolic process (GO:0046185)3.25657736
83positive regulation of male gonad development (GO:2000020)3.24139672
84base-excision repair, AP site formation (GO:0006285)3.22245613
85aminoglycan biosynthetic process (GO:0006023)3.22136835
86glycosaminoglycan biosynthetic process (GO:0006024)3.21870765
87determination of adult lifespan (GO:0008340)3.21404809
88multicellular organismal metabolic process (GO:0044236)3.20428263
89myelin assembly (GO:0032288)3.19293833
90iron ion import (GO:0097286)3.19133641
91regulation of digestive system process (GO:0044058)3.16735700
92pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.16152431
93response to gravity (GO:0009629)3.14890355
94xenobiotic catabolic process (GO:0042178)3.12995698
95regulation of vasculogenesis (GO:2001212)3.11892200
96maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.11659118
97neural crest cell development (GO:0014032)3.11199034
98mannose metabolic process (GO:0006013)3.09903600
99positive regulation of calcium ion import (GO:0090280)3.09385441
100regulation of guanylate cyclase activity (GO:0031282)3.08224655
101behavioral response to ethanol (GO:0048149)3.08051246
102short-term memory (GO:0007614)3.05366121
103thyroid gland development (GO:0030878)3.04480740
104regulation of chondrocyte differentiation (GO:0032330)3.04080619
105mesodermal cell differentiation (GO:0048333)3.03943836
106regulation of meiosis I (GO:0060631)3.02783878
107protein heterotetramerization (GO:0051290)3.02588394
108cellular anion homeostasis (GO:0030002)3.02099255
109regulation of integrin-mediated signaling pathway (GO:2001044)2.98695395
110N-glycan processing (GO:0006491)2.97897137
111quaternary ammonium group transport (GO:0015697)2.96838960
112endodermal cell differentiation (GO:0035987)2.93246607
113sequestering of extracellular ligand from receptor (GO:0035581)2.92622208
114cofactor catabolic process (GO:0051187)2.91811071
115negative regulation of keratinocyte proliferation (GO:0010839)2.91608232
116phosphate ion homeostasis (GO:0055062)2.88563091
117trivalent inorganic anion homeostasis (GO:0072506)2.88563091
118endothelial cell morphogenesis (GO:0001886)2.88189840
119mesenchymal-epithelial cell signaling (GO:0060638)2.86664605
120regulation of glucocorticoid secretion (GO:2000849)2.85809813
121spermatid nucleus differentiation (GO:0007289)2.83512635
122omega-hydroxylase P450 pathway (GO:0097267)2.82192388
123heart valve formation (GO:0003188)2.81670856
124peptidyl-histidine modification (GO:0018202)2.81277078
125cranial nerve structural organization (GO:0021604)2.80247133
126positive regulation of guanylate cyclase activity (GO:0031284)2.80171955
127activation of protein kinase A activity (GO:0034199)2.79554295
128negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.79066345
129detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.75271194
130cartilage morphogenesis (GO:0060536)2.75058650
131regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.74514496
132positive regulation of interleukin-17 production (GO:0032740)2.74436985
133regulation of interleukin-8 secretion (GO:2000482)2.74233666
134positive regulation of megakaryocyte differentiation (GO:0045654)2.73802315
135RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.73039311
136extracellular matrix disassembly (GO:0022617)2.72931441
137epithelial to mesenchymal transition (GO:0001837)2.72688501
138regulation of necrotic cell death (GO:0010939)2.72513096
139adenosine metabolic process (GO:0046085)2.70938816
140regulation of cartilage development (GO:0061035)2.70862776
141ether lipid metabolic process (GO:0046485)2.69586599
142regulation of cGMP biosynthetic process (GO:0030826)2.69001516
143negative regulation of chondrocyte differentiation (GO:0032331)2.67487626
144angiotensin maturation (GO:0002003)2.67363767
145embryonic skeletal system morphogenesis (GO:0048704)2.65842293
146cellular glucuronidation (GO:0052695)2.65333009
147regulation of extracellular matrix disassembly (GO:0010715)2.64757036
148regulation of rhodopsin mediated signaling pathway (GO:0022400)2.63787457
149negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.63613225
150purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.63187788
1513-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.63187788
152connective tissue development (GO:0061448)2.63073191
153negative regulation of T cell differentiation in thymus (GO:0033085)2.62815967
154protein polyglutamylation (GO:0018095)2.61104030
155maternal behavior (GO:0042711)2.60747739
156regulation of B cell differentiation (GO:0045577)2.59957900
157regulation of steroid hormone secretion (GO:2000831)2.59938384
158maintenance of gastrointestinal epithelium (GO:0030277)2.59540358
159sulfation (GO:0051923)2.59505668
160peptidyl-proline hydroxylation (GO:0019511)2.58314945
161neural tube formation (GO:0001841)2.58259219
162ribosomal large subunit biogenesis (GO:0042273)2.57225426
163rhodopsin mediated signaling pathway (GO:0016056)2.56806198
164response to pain (GO:0048265)2.55250400
165regulation of mesenchymal cell apoptotic process (GO:2001053)2.54301512
166carnitine shuttle (GO:0006853)2.53189192
167GPI anchor metabolic process (GO:0006505)2.52968205
168extracellular matrix organization (GO:0030198)2.52686916
169regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.52084161
170megakaryocyte development (GO:0035855)2.51926606
171parental behavior (GO:0060746)2.51708673
172glucuronate metabolic process (GO:0019585)2.51186588
173uronic acid metabolic process (GO:0006063)2.51186588
174extracellular structure organization (GO:0043062)2.51084908
175regulation of transmission of nerve impulse (GO:0051969)2.51068307
176estrogen biosynthetic process (GO:0006703)2.50645380
177positive regulation of cGMP biosynthetic process (GO:0030828)2.49679137
178positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.49525805
179positive regulation of protein autophosphorylation (GO:0031954)2.49001379
180regulation of cellular senescence (GO:2000772)2.47752884
181middle ear morphogenesis (GO:0042474)2.47425883
182negative regulation of response to extracellular stimulus (GO:0032105)2.47354395
183negative regulation of response to nutrient levels (GO:0032108)2.47354395
184phosphatidylinositol acyl-chain remodeling (GO:0036149)2.46989930
185regulation of bone mineralization (GO:0030500)2.46716658
186nerve growth factor signaling pathway (GO:0038180)2.46675322
187negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.46286621
188negative regulation of neurotransmitter secretion (GO:0046929)2.46183563
189chondroitin sulfate metabolic process (GO:0030204)2.45523415
190mesenchymal cell development (GO:0014031)2.44945544
191signal peptide processing (GO:0006465)2.44653290
192hepatocyte differentiation (GO:0070365)2.44331012
193regulation of vitamin metabolic process (GO:0030656)2.43040850
194phospholipid scrambling (GO:0017121)2.41940892
195negative regulation of smooth muscle cell differentiation (GO:0051151)2.41531595
196mesenchymal cell differentiation (GO:0048762)2.40107083

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.10687857
2IGF1R_20145208_ChIP-Seq_DFB_Human4.43671048
3SMAD_19615063_ChIP-ChIP_OVARY_Human4.38542228
4VDR_22108803_ChIP-Seq_LS180_Human4.01127095
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.88094701
6SCL_19346495_ChIP-Seq_HPC-7_Human3.27370889
7CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.85700561
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.80281680
9ZNF274_21170338_ChIP-Seq_K562_Hela2.73455501
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.70554063
11TAF15_26573619_Chip-Seq_HEK293_Human2.39150158
12CDX2_20551321_ChIP-Seq_CACO-2_Human2.29657649
13AR_21572438_ChIP-Seq_LNCaP_Human2.23968445
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.21968983
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.19903334
16CJUN_26792858_Chip-Seq_BT549_Human2.16820642
17* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.16718247
18GBX2_23144817_ChIP-Seq_PC3_Human2.13754802
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.09415732
20SUZ12_27294783_Chip-Seq_NPCs_Mouse2.09225335
21SOX2_20726797_ChIP-Seq_SW620_Human2.07663174
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.06068208
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.98911845
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.97099006
25TP53_18474530_ChIP-ChIP_U2OS_Human1.96377613
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.94827902
27NFE2_27457419_Chip-Seq_LIVER_Mouse1.94629323
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.91415058
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.90666838
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87801096
31WT1_19549856_ChIP-ChIP_CCG9911_Human1.86418840
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.84578237
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.79387345
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.79249789
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.75189856
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73823561
37EZH2_27294783_Chip-Seq_NPCs_Mouse1.73436478
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.71333713
39NRF2_20460467_ChIP-Seq_MEFs_Mouse1.70839796
40NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.70839796
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68559024
42IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.66423392
43CBP_20019798_ChIP-Seq_JUKART_Human1.66423392
44FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.63323030
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.62198720
46ELK1_22589737_ChIP-Seq_MCF10A_Human1.61991819
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61564662
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61462574
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59023774
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58886620
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.57784262
52BRD4_25478319_ChIP-Seq_HGPS_Human1.57554420
53* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55756874
54P53_22387025_ChIP-Seq_ESCs_Mouse1.55001133
55ER_23166858_ChIP-Seq_MCF-7_Human1.54558294
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54533518
57* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.54362737
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51939278
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.51106190
60SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.50660862
61SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.50660862
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50428048
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48230328
64* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.46175217
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.46082721
66* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.45431083
67EZH2_27304074_Chip-Seq_ESCs_Mouse1.43281177
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.41579802
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41120572
70SMAD4_21799915_ChIP-Seq_A2780_Human1.39015335
71SUZ12_18555785_Chip-Seq_ESCs_Mouse1.38387887
72ESR1_21235772_ChIP-Seq_MCF-7_Human1.37598761
73AR_20517297_ChIP-Seq_VCAP_Human1.37148805
74CDX2_22108803_ChIP-Seq_LS180_Human1.37074604
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37011736
76TCF4_18268006_ChIP-ChIP_LS174T_Human1.36755253
77STAT3_18555785_Chip-Seq_ESCs_Mouse1.36565100
78SOX2_19829295_ChIP-Seq_ESCs_Human1.36217984
79NANOG_19829295_ChIP-Seq_ESCs_Human1.36217984
80ELK1_19687146_ChIP-ChIP_HELA_Human1.34382484
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.33791482
82FUS_26573619_Chip-Seq_HEK293_Human1.33550029
83* E2F1_18555785_Chip-Seq_ESCs_Mouse1.32888024
84FLI1_21867929_ChIP-Seq_TH2_Mouse1.32578249
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31957763
86JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30598717
87TAL1_26923725_Chip-Seq_HPCs_Mouse1.30554658
88PIAS1_25552417_ChIP-Seq_VCAP_Human1.29786990
89* NANOG_18555785_Chip-Seq_ESCs_Mouse1.28727383
90* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.27743791
91FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27592031
92FOXA1_25329375_ChIP-Seq_VCAP_Human1.27592031
93P300_18555785_Chip-Seq_ESCs_Mouse1.26908288
94* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25207720
95RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24880173
96JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24432362
97CMYC_18555785_Chip-Seq_ESCs_Mouse1.24382870
98HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24150370
99* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.23224412
100NMYC_18555785_Chip-Seq_ESCs_Mouse1.22614571
101SALL1_21062744_ChIP-ChIP_HESCs_Human1.22180575
102STAT3_23295773_ChIP-Seq_U87_Human1.20811496
103* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20528857
104TP53_22573176_ChIP-Seq_HFKS_Human1.20332303
105NCOR_22424771_ChIP-Seq_293T_Human1.20312183
106EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.20259486
107CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19789441
108* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18385832
109P300_19829295_ChIP-Seq_ESCs_Human1.18102166
110GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16577059
111FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.16294310
112AUTS2_25519132_ChIP-Seq_293T-REX_Human1.16264708
113SOX2_18555785_Chip-Seq_ESCs_Mouse1.16245786
114EWS_26573619_Chip-Seq_HEK293_Human1.16106694
115MYC_18940864_ChIP-ChIP_HL60_Human1.15841955
116PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.15723794
117CRX_20693478_ChIP-Seq_RETINA_Mouse1.15715987
118SA1_22415368_ChIP-Seq_MEFs_Mouse1.15652030
119* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14821513
120SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14812684
121GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14398177
122IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14367570
123ERG_20517297_ChIP-Seq_VCAP_Human1.14090119
124FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13736310
125FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.13618376
126GATA1_22025678_ChIP-Seq_K562_Human1.13237919
127* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11719487
128TCF4_23295773_ChIP-Seq_U87_Human1.11591096
129TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.10886147
130VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09812802
131RNF2_27304074_Chip-Seq_NSC_Mouse1.09592940
132* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09321685
133* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09321685
134NANOG_20526341_ChIP-Seq_ESCs_Human1.09125122
135ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.08559664
136MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08146138
137BCAT_22108803_ChIP-Seq_LS180_Human1.07802076
138EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07597204
139TP63_19390658_ChIP-ChIP_HaCaT_Human1.06801465
140SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06543828
141* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.06485416
142AR_25329375_ChIP-Seq_VCAP_Human1.06327467
143TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05362150
144ESRRB_18555785_Chip-Seq_ESCs_Mouse1.05307121
145CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04629736
146SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04613467
147TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04019639
148OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03933067
149MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03841474
150TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03183320
151PU1_27457419_Chip-Seq_LIVER_Mouse1.02678053
152STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02469022
153* JUN_21703547_ChIP-Seq_K562_Human1.02418227
154ZFX_18555785_Chip-Seq_ESCs_Mouse1.02135670
155VDR_24787735_ChIP-Seq_THP-1_Human1.01684735
156ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00758033
157GATA3_21878914_ChIP-Seq_MCF-7_Human1.00674632
158PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00476519
159NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99343152
160ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98809067
161RUNX2_22187159_ChIP-Seq_PCA_Human0.98365289
162IKZF1_21737484_ChIP-ChIP_HCT116_Human0.98338141
163SMAD3_21741376_ChIP-Seq_EPCs_Human0.97774614
164KLF4_18555785_Chip-Seq_ESCs_Mouse0.97710402
165ELF5_23300383_ChIP-Seq_T47D_Human0.96779596

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system4.89561796
2MP0005503_abnormal_tendon_morphology4.68180980
3MP0004134_abnormal_chest_morphology4.51541774
4MP0002933_joint_inflammation4.06972800
5MP0009250_abnormal_appendicular_skeleto3.89830536
6MP0002282_abnormal_trachea_morphology3.73349930
7MP0000013_abnormal_adipose_tissue3.18037597
8* MP0000163_abnormal_cartilage_morphology3.07517890
9MP0000678_abnormal_parathyroid_gland3.03821873
10MP0005360_urolithiasis3.03559432
11MP0001188_hyperpigmentation2.94753738
12MP0002089_abnormal_postnatal_growth/wei2.72613156
13MP0001542_abnormal_bone_strength2.71538492
14MP0003183_abnormal_peptide_metabolism2.71464174
15MP0009697_abnormal_copulation2.62431690
16MP0008438_abnormal_cutaneous_collagen2.53028393
17* MP0002115_abnormal_skeleton_extremities2.49536503
18MP0005085_abnormal_gallbladder_physiolo2.42645095
19MP0000049_abnormal_middle_ear2.33394962
20* MP0002113_abnormal_skeleton_development2.29275702
21MP0003646_muscle_fatigue2.28691635
22MP0009384_cardiac_valve_regurgitation2.26642939
23MP0005508_abnormal_skeleton_morphology2.24965977
24MP0001299_abnormal_eye_distance/2.22923340
25MP0003718_maternal_effect2.22257744
26MP0002896_abnormal_bone_mineralization2.20534425
27MP0002163_abnormal_gland_morphology2.19886266
28MP0005670_abnormal_white_adipose2.15787226
29MP0000762_abnormal_tongue_morphology2.07837415
30MP0009379_abnormal_foot_pigmentation2.07269102
31MP0005551_abnormal_eye_electrophysiolog2.06595122
32MP0005645_abnormal_hypothalamus_physiol2.05680351
33MP0002234_abnormal_pharynx_morphology2.04174285
34MP0005390_skeleton_phenotype2.02355506
35MP0008004_abnormal_stomach_pH1.98026091
36MP0002877_abnormal_melanocyte_morpholog1.95174678
37MP0001968_abnormal_touch/_nociception1.94832827
38MP0010030_abnormal_orbit_morphology1.93650622
39MP0002138_abnormal_hepatobiliary_system1.90555213
40* MP0002109_abnormal_limb_morphology1.89246256
41MP0005464_abnormal_platelet_physiology1.85875338
42MP0005397_hematopoietic_system_phenotyp1.84788819
43MP0001545_abnormal_hematopoietic_system1.84788819
44* MP0001664_abnormal_digestion1.83365576
45MP0000383_abnormal_hair_follicle1.81806779
46MP0004043_abnormal_pH_regulation1.81099079
47MP0003279_aneurysm1.80208657
48MP0004147_increased_porphyrin_level1.79833906
49MP0001533_abnormal_skeleton_physiology1.74180888
50MP0003283_abnormal_digestive_organ1.72690190
51MP0003755_abnormal_palate_morphology1.70143794
52MP0001270_distended_abdomen1.70079562
53MP0000681_abnormal_thyroid_gland1.65170284
54MP0003795_abnormal_bone_structure1.61019589
55MP0002233_abnormal_nose_morphology1.58701118
56MP0000230_abnormal_systemic_arterial1.58010299
57MP0003656_abnormal_erythrocyte_physiolo1.57508198
58MP0002249_abnormal_larynx_morphology1.56976321
59MP0003385_abnormal_body_wall1.52110094
60MP0001666_abnormal_nutrient_absorption1.51974003
61MP0001663_abnormal_digestive_system1.51543063
62MP0003252_abnormal_bile_duct1.51386997
63MP0009278_abnormal_bone_marrow1.48543111
64MP0005275_abnormal_skin_tensile1.45892143
65MP0006072_abnormal_retinal_apoptosis1.45303921
66MP0009780_abnormal_chondrocyte_physiolo1.44267215
67MP0005084_abnormal_gallbladder_morpholo1.43884624
68MP0001764_abnormal_homeostasis1.42840237
69MP0004272_abnormal_basement_membrane1.42044930
70MP0001501_abnormal_sleep_pattern1.41229593
71MP0000432_abnormal_head_morphology1.39058478
72MP0008872_abnormal_physiological_respon1.38106625
73MP0003937_abnormal_limbs/digits/tail_de1.37844848
74* MP0002116_abnormal_craniofacial_bone1.35821017
75MP0005332_abnormal_amino_acid1.32897591
76MP0003091_abnormal_cell_migration1.32238077
77MP0001765_abnormal_ion_homeostasis1.30256294
78MP0005381_digestive/alimentary_phenotyp1.30159312
79MP0000749_muscle_degeneration1.29739789
80MP0004215_abnormal_myocardial_fiber1.23890491
81MP0005023_abnormal_wound_healing1.23252054
82MP0002653_abnormal_ependyma_morphology1.22796154
83MP0009643_abnormal_urine_homeostasis1.22348308
84MP0000372_irregular_coat_pigmentation1.21528010
85MP0001529_abnormal_vocalization1.21486641
86MP0003941_abnormal_skin_development1.20095633
87MP0005636_abnormal_mineral_homeostasis1.19718635
88MP0002998_abnormal_bone_remodeling1.19491776
89MP0006276_abnormal_autonomic_nervous1.19120701
90MP0000566_synostosis1.17802564
91MP0003136_yellow_coat_color1.17733546
92MP0010386_abnormal_urinary_bladder1.17368826
93MP0005253_abnormal_eye_physiology1.15393641
94MP0001905_abnormal_dopamine_level1.14526190
95MP0001986_abnormal_taste_sensitivity1.14396155
96MP0002932_abnormal_joint_morphology1.14192567
97MP0005623_abnormal_meninges_morphology1.13079200
98MP0004484_altered_response_of1.12028955
99MP0002139_abnormal_hepatobiliary_system1.11623197
100MP0005410_abnormal_fertilization1.11126836
101MP0002733_abnormal_thermal_nociception1.09621376
102MP0008875_abnormal_xenobiotic_pharmacok1.08851459
103MP0003950_abnormal_plasma_membrane1.08054885
104MP0002735_abnormal_chemical_nociception1.07225216
105MP0004264_abnormal_extraembryonic_tissu1.05023320
106MP0001958_emphysema1.04919097
107MP0001486_abnormal_startle_reflex1.04028477
108MP0000462_abnormal_digestive_system1.03709976
109MP0003567_abnormal_fetal_cardiomyocyte1.03584944
110MP0002177_abnormal_outer_ear1.02400133
111* MP0002114_abnormal_axial_skeleton1.01797831
112MP0003806_abnormal_nucleotide_metabolis0.99731595
113MP0003942_abnormal_urinary_system0.99352034
114MP0002111_abnormal_tail_morphology0.98926235
115MP0005535_abnormal_body_temperature0.97161854
116MP0002060_abnormal_skin_morphology0.96521154
117MP0002108_abnormal_muscle_morphology0.95998234
118MP0004782_abnormal_surfactant_physiolog0.94575304
119MP0001835_abnormal_antigen_presentation0.94055168
120MP0005409_darkened_coat_color0.93066887
121MP0000751_myopathy0.92338473
122MP0005367_renal/urinary_system_phenotyp0.91754658
123MP0000516_abnormal_urinary_system0.91754658
124MP0010678_abnormal_skin_adnexa0.91366162
125MP0005171_absent_coat_pigmentation0.90907108
126MP0008007_abnormal_cellular_replicative0.90632859
127MP0000428_abnormal_craniofacial_morphol0.90369518
128MP0001873_stomach_inflammation0.89900889
129MP0002736_abnormal_nociception_after0.89401759
130MP0002160_abnormal_reproductive_system0.88636487
131MP0005075_abnormal_melanosome_morpholog0.88389312
132MP0003935_abnormal_craniofacial_develop0.88002079
133MP0000015_abnormal_ear_pigmentation0.86362764
134MP0005174_abnormal_tail_pigmentation0.85691006
135MP0002136_abnormal_kidney_physiology0.85666427
136MP0008775_abnormal_heart_ventricle0.85333705
137MP0000465_gastrointestinal_hemorrhage0.84359967
138MP0001984_abnormal_olfaction0.83614844
139MP0005164_abnormal_response_to0.83334260
140MP0006292_abnormal_olfactory_placode0.81353485
141MP0002572_abnormal_emotion/affect_behav0.79583831
142MP0006054_spinal_hemorrhage0.79349862
143MP0002876_abnormal_thyroid_physiology0.79177380
144MP0010155_abnormal_intestine_physiology0.78824002
145MP0003195_calcinosis0.78095554
146MP0002837_dystrophic_cardiac_calcinosis0.77739688
147MP0002822_catalepsy0.77561701
148MP0003123_paternal_imprinting0.76541546
149MP0002971_abnormal_brown_adipose0.76234882
150MP0000490_abnormal_crypts_of0.74459878
151MP0005448_abnormal_energy_balance0.74433723
152MP0001963_abnormal_hearing_physiology0.74424511
153MP0005334_abnormal_fat_pad0.73082114
154MP0002148_abnormal_hypersensitivity_rea0.73005866
155MP0001879_abnormal_lymphatic_vessel0.72998381
156MP0005379_endocrine/exocrine_gland_phen0.72961648
157MP0003436_decreased_susceptibility_to0.72879814
158MP0002132_abnormal_respiratory_system0.71967884
159MP0005646_abnormal_pituitary_gland0.71852533
160MP0002751_abnormal_autonomic_nervous0.71581648
161MP0001177_atelectasis0.71572261
162MP0004019_abnormal_vitamin_homeostasis0.71406825
163MP0005365_abnormal_bile_salt0.71152628
164MP0000538_abnormal_urinary_bladder0.71074873
165MP0002102_abnormal_ear_morphology0.70755966
166MP0003880_abnormal_central_pattern0.69446390
167MP0000604_amyloidosis0.69359868
168MP0003943_abnormal_hepatobiliary_system0.68379759
169MP0003705_abnormal_hypodermis_morpholog0.68233084
170MP0000689_abnormal_spleen_morphology0.66696965
171MP0005666_abnormal_adipose_tissue0.66651605
172MP0001286_abnormal_eye_development0.66109284
173MP0003303_peritoneal_inflammation0.66043187
174MP0004808_abnormal_hematopoietic_stem0.65914651
175MP0000767_abnormal_smooth_muscle0.64915464
176MP0001243_abnormal_dermal_layer0.64773868
177MP0009333_abnormal_splenocyte_physiolog0.64542530
178MP0001919_abnormal_reproductive_system0.64384095
179MP0003724_increased_susceptibility_to0.64080500
180MP0001348_abnormal_lacrimal_gland0.62310987
181MP0001970_abnormal_pain_threshold0.61776263
182MP0004924_abnormal_behavior0.61094035
183MP0005386_behavior/neurological_phenoty0.61094035
184MP0000026_abnormal_inner_ear0.60709147

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)8.37839062
2Irregular epiphyses (HP:0010582)8.37443837
3Vitreoretinal degeneration (HP:0000655)6.99974083
4Cupped ribs (HP:0000887)6.03812976
5Hypoplastic ischia (HP:0003175)5.36375318
6Small epiphyses (HP:0010585)5.27900646
7Abnormal tarsal ossification (HP:0008369)5.25815391
8Flat capital femoral epiphysis (HP:0003370)5.11708876
9Failure to thrive in infancy (HP:0001531)5.05549601
10Generalized aminoaciduria (HP:0002909)5.03027379
11Neonatal short-limb short stature (HP:0008921)4.89015086
12Delayed epiphyseal ossification (HP:0002663)4.73567654
13Genu varum (HP:0002970)4.71189643
14Abnormality of the ischium (HP:0003174)4.68824984
15Flat acetabular roof (HP:0003180)4.63731054
16Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.48909851
17Hypophosphatemic rickets (HP:0004912)4.31454930
18Abnormality of macular pigmentation (HP:0008002)4.30570589
19Renal Fanconi syndrome (HP:0001994)4.23208687
20Absent rod-and cone-mediated responses on ERG (HP:0007688)4.19105767
21Abnormality of the costochondral junction (HP:0000919)4.14291688
22Decreased central vision (HP:0007663)4.13356823
23Acute lymphatic leukemia (HP:0006721)3.97598254
24Abnormal foot bone ossification (HP:0010675)3.96843186
25Mild short stature (HP:0003502)3.95882184
26Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.87465700
27Abnormality of femoral epiphyses (HP:0006499)3.87465700
28Flattened epiphyses (HP:0003071)3.80576706
29Central scotoma (HP:0000603)3.78485802
30Metaphyseal dysplasia (HP:0100255)3.77333092
31Short femoral neck (HP:0100864)3.76804613
32Abolished electroretinogram (ERG) (HP:0000550)3.66151029
33Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.60312268
34Stomach cancer (HP:0012126)3.60127655
35Abnormality of the vertebral endplates (HP:0005106)3.57998278
36Metaphyseal cupping (HP:0003021)3.55358162
37Abnormality of the epiphysis of the femoral head (HP:0010574)3.48290048
38Arthropathy (HP:0003040)3.45113059
39Abnormal drinking behavior (HP:0030082)3.44569033
40Polydipsia (HP:0001959)3.44569033
41Dyschromatopsia (HP:0007641)3.41052385
42Osteoarthritis (HP:0002758)3.39124594
43Male infertility (HP:0003251)3.35920064
44Cervical subluxation (HP:0003308)3.34367226
45Abnormal rod and cone electroretinograms (HP:0008323)3.32817961
46Beaking of vertebral bodies (HP:0004568)3.29831535
47Abnormality of the femoral head (HP:0003368)3.29577730
48Abnormality of urine glucose concentration (HP:0011016)3.27599736
49Glycosuria (HP:0003076)3.27599736
50Irregular vertebral endplates (HP:0003301)3.25851868
51Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.25428995
52Absent epiphyses (HP:0010577)3.25428995
53Abnormality of incisor morphology (HP:0011063)3.24657471
54Abnormality of the phalanges of the 2nd finger (HP:0009541)3.23873718
55Tetany (HP:0001281)3.19027978
56Abnormality of the proximal phalanges of the hand (HP:0009834)3.16530117
57Metaphyseal irregularity (HP:0003025)3.12750349
58Abnormality of the vitamin B12 metabolism (HP:0004341)3.07016342
59Attenuation of retinal blood vessels (HP:0007843)3.03966540
60Coxa vara (HP:0002812)3.02785702
61Abnormal vertebral ossification (HP:0100569)2.97386862
62Abnormality of carpal bone ossification (HP:0006257)2.95204989
63Stillbirth (HP:0003826)2.94259230
64Abnormality of vitamin B metabolism (HP:0004340)2.91508482
65Spinal cord compression (HP:0002176)2.91230856
66Panhypogammaglobulinemia (HP:0003139)2.89876087
67Absent frontal sinuses (HP:0002688)2.87286071
68Aplasia/hypoplasia of the femur (HP:0005613)2.81632605
69Congenital stationary night blindness (HP:0007642)2.77718328
70Platyspondyly (HP:0000926)2.73641866
71Abnormality of glutamine family amino acid metabolism (HP:0010902)2.72088488
72Abnormality of fatty-acid metabolism (HP:0004359)2.68785222
73Medial flaring of the eyebrow (HP:0010747)2.68463591
74Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.63956090
75Abnormality of B cell number (HP:0010975)2.60431454
76Recurrent corneal erosions (HP:0000495)2.60036068
77Abnormality of the 2nd finger (HP:0004100)2.59209164
78Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.58227958
79Abnormality of the pubic bones (HP:0003172)2.57433114
80Cone-rod dystrophy (HP:0000548)2.56835194
81Thoracolumbar scoliosis (HP:0002944)2.56148366
82Abnormality of renal resorption (HP:0011038)2.54452598
83Abnormality of the phalanges of the 5th finger (HP:0004213)2.50049304
84Enlarged epiphyses (HP:0010580)2.49673768
85Limited hip movement (HP:0008800)2.49068617
86Barrel-shaped chest (HP:0001552)2.48239240
87Decreased electroretinogram (ERG) amplitude (HP:0000654)2.45958663
88Limited elbow extension (HP:0001377)2.44604037
89Mesomelia (HP:0003027)2.41515327
90Renal cortical cysts (HP:0000803)2.39814358
91Ovoid vertebral bodies (HP:0003300)2.39472463
92Thin ribs (HP:0000883)2.38457675
93Waddling gait (HP:0002515)2.37586758
94Methylmalonic acidemia (HP:0002912)2.36986800
95Hypoplastic ilia (HP:0000946)2.35263970
96Hypoglycemic seizures (HP:0002173)2.34416181
97Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32911939
98Abnormality of alanine metabolism (HP:0010916)2.32911939
99Hyperalaninemia (HP:0003348)2.32911939
100Hyperglycinuria (HP:0003108)2.32543598
101Congenital primary aphakia (HP:0007707)2.32450389
102Abnormality of the frontal sinuses (HP:0002687)2.29139429
103Protuberant abdomen (HP:0001538)2.28135287
104Reduced antithrombin III activity (HP:0001976)2.26507207
105Polyuria (HP:0000103)2.26359036
106Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.26304394
107Scotoma (HP:0000575)2.25521597
108Gait imbalance (HP:0002141)2.25437520
109Congenital hepatic fibrosis (HP:0002612)2.25256973
110Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.24802686
111Hypoplasia of the odontoid process (HP:0003311)2.23577330
112Hip contracture (HP:0003273)2.23568932
113Long clavicles (HP:0000890)2.23518934
114Abnormality of glycine metabolism (HP:0010895)2.23060468
115Abnormality of serine family amino acid metabolism (HP:0010894)2.23060468
116Lumbar hyperlordosis (HP:0002938)2.22911466
117Decreased circulating renin level (HP:0003351)2.22759239
118Abnormal hand bone ossification (HP:0010660)2.22346702
119Abnormal ossification of hand bones (HP:0005921)2.20594070
120Vertebral clefting (HP:0008428)2.18671250
121Nephrogenic diabetes insipidus (HP:0009806)2.18338920
122Portal hypertension (HP:0001409)2.17526774
123Fibular hypoplasia (HP:0003038)2.17435674
124Absent/shortened dynein arms (HP:0200106)2.16870187
125Dynein arm defect of respiratory motile cilia (HP:0012255)2.16870187
126Abnormal delayed hypersensitivity skin test (HP:0002963)2.16683224
127Nonprogressive disorder (HP:0003680)2.15760364
128Short middle phalanx of finger (HP:0005819)2.15431291
129Abnormality of the prostate (HP:0008775)2.14532391
130Abnormal urine output (HP:0012590)2.14426879
131Chronic otitis media (HP:0000389)2.13912738
132Glossoptosis (HP:0000162)2.13591916
133Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.12376389
134Vertebral hypoplasia (HP:0008417)2.12376389
135Elevated erythrocyte sedimentation rate (HP:0003565)2.11690260
136Radial bowing (HP:0002986)2.10565030
137Exostoses (HP:0100777)2.10398282
138Ileus (HP:0002595)2.10223091
139Micromelia (HP:0002983)2.10092274
140Colon cancer (HP:0003003)2.07830653
141Abnormality of potassium homeostasis (HP:0011042)2.07827481
142Hyperphosphatemia (HP:0002905)2.07742676
143Abnormality of sulfur amino acid metabolism (HP:0004339)2.06020378
144Hypokalemia (HP:0002900)2.05845209
145Premature rupture of membranes (HP:0001788)2.05662874
146Abnormality of proline metabolism (HP:0010907)2.04685580
147Hydroxyprolinuria (HP:0003080)2.04685580
148Syringomyelia (HP:0003396)2.04083650
149Spinal cord lesions (HP:0100561)2.04083650
150Hypoplastic pelvis (HP:0008839)2.02142407
151Macular degeneration (HP:0000608)2.01000867
152Disproportionate short-trunk short stature (HP:0003521)2.00937650
153Type I diabetes mellitus (HP:0100651)2.00770341
154Abnormality of the acetabulum (HP:0003170)1.98687494
155Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.97831126
156Abnormal protein N-linked glycosylation (HP:0012347)1.97831126
157Abnormal protein glycosylation (HP:0012346)1.97831126
158Abnormal glycosylation (HP:0012345)1.97831126
159Abnormality of the vitreous humor (HP:0004327)1.97812719
160Abnormality of the lumbar spine (HP:0100712)1.97331390
161Tracheomalacia (HP:0002779)1.95997362
162Methylmalonic aciduria (HP:0012120)1.95749575
163Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.95336371
164Constricted visual fields (HP:0001133)1.94572689
165Carpal bone hypoplasia (HP:0001498)1.93622108
166Agammaglobulinemia (HP:0004432)1.92990916
167Flared metaphyses (HP:0003015)1.92606278
168Abnormality of the hepatic vasculature (HP:0006707)1.91670148
169Delayed puberty (HP:0000823)1.89795208
170Abnormality of the odontoid process (HP:0003310)1.89662881
171Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.86479487
172Hyperglycinemia (HP:0002154)1.85790434
173Metabolic acidosis (HP:0001942)1.85776277
174Confusion (HP:0001289)1.85621503
175Decreased skull ossification (HP:0004331)1.85260353
176Facial diplegia (HP:0001349)1.85156167
177Hypoplastic iliac wings (HP:0002866)1.84689427
178Aplasia/Hypoplasia of the scapulae (HP:0006713)1.83485201
179Hypoplastic scapulae (HP:0000882)1.83485201
180Atrioventricular block (HP:0001678)1.83469630
181Pigmentary retinal degeneration (HP:0001146)1.83282385
182Abnormality of the renal cortex (HP:0011035)1.82841539
183Ketosis (HP:0001946)1.82760556
184Abnormality of vitamin metabolism (HP:0100508)1.81975818
185Alveolar cell carcinoma (HP:0006519)1.80473680
186Chorioretinal atrophy (HP:0000533)1.79313933
187Abnormality of renal excretion (HP:0011036)1.79011761
188Broad phalanx (HP:0006009)1.78972230
189Abnormality of the middle phalanges of the hand (HP:0009833)1.77869306
190Nephronophthisis (HP:0000090)1.77208050
191Genital tract atresia (HP:0001827)1.76533606
192Hyperkalemia (HP:0002153)1.75415316
193Thyroid-stimulating hormone excess (HP:0002925)1.75069899
194Asplenia (HP:0001746)1.74022367
195Symptomatic seizures (HP:0011145)1.73945849
196Pancreatic cysts (HP:0001737)1.73943574
197Chronic diarrhea (HP:0002028)1.73935607
198Abnormality of calcium-phosphate metabolism (HP:0100530)1.72909712
199Spontaneous abortion (HP:0005268)1.70078099

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FLT34.91354762
2MUSK4.85945562
3DDR24.80201273
4CASK3.75587086
5TAOK33.69572577
6MKNK23.26890520
7MST42.91507134
8MKNK12.83744391
9SCYL22.77233774
10BCKDK2.75159180
11MAP3K32.74035196
12MAP4K22.69976121
13NME22.68397492
14STK38L2.65479535
15DAPK22.51579297
16ERBB32.49551229
17LMTK22.44019576
18PINK12.36852326
19STK242.35591441
20MAP3K62.31478052
21NUAK12.26447181
22PIM22.21571815
23TRPM72.19579928
24NME12.03375803
25CSF1R2.00387224
26SRPK11.87282821
27EIF2AK31.81719473
28MAP2K61.79958338
29* PRKG21.76417301
30MAP4K11.71465700
31IKBKE1.70276656
32TNIK1.65334737
33EIF2AK11.57832056
34FRK1.51957225
35ACVR1B1.50537905
36ZAK1.46610932
37PIK3CA1.42059780
38CDK81.38833085
39ZAP701.31669723
40LATS11.29802199
41NEK61.29672471
42EPHA21.26972881
43CAMKK21.20975149
44ITK1.16780167
45EIF2AK21.16238734
46BMPR1B1.14296548
47PLK21.13140137
48MAP2K41.11440710
49PRKCQ1.08422059
50RPS6KB21.08136767
51MAP3K41.07257742
52SYK1.05674748
53MAP3K141.05300527
54STK31.02389598
55WNK31.01225243
56INSRR0.99691413
57EPHB20.99463126
58YES10.99417602
59STK160.96714381
60ROCK10.93913156
61MAP3K120.93461628
62NEK90.93012290
63DYRK1B0.91574213
64PBK0.90187470
65BLK0.87720958
66MAP3K70.85520113
67TXK0.81844502
68RPS6KA60.81534555
69NLK0.81084636
70BTK0.79370067
71DAPK10.79223180
72MAP3K50.79158839
73RPS6KA40.77723315
74MOS0.77668020
75TIE10.77550554
76TLK10.77429119
77WNK40.73836954
78BRSK20.73411732
79FES0.73078744
80RPS6KL10.72765748
81RPS6KC10.72765748
82OXSR10.72738926
83MAPKAPK50.72682540
84MST1R0.72662240
85LIMK10.71013430
86BMPR20.70671288
87IRAK30.66485261
88IKBKB0.66203059
89MAP2K70.65456111
90ADRBK20.65024217
91TAF10.62226204
92PRPF4B0.61558963
93STK390.60932842
94KDR0.60295647
95PRKCH0.60013990
96MATK0.59249060
97SIK30.56801610
98MAP3K110.55997473
99VRK20.55849360
100CDK30.54003676
101TAOK20.53734674
102TESK10.53634234
103LCK0.52958623
104MAP3K10.52707443
105TGFBR10.52450273
106TEC0.52226206
107DAPK30.51868817
108MYLK0.48660844
109PAK20.47659343
110PRKD20.47348543
111TNK20.46804481
112IRAK40.46484710
113MAP2K30.45323888
114HCK0.44955314
115VRK10.44574624
116PIM10.44384296
117GRK10.44324446
118FER0.42653105
119ADRBK10.42272279
120DYRK1A0.41879243
121AKT30.41800374
122CDK190.41474850
123CCNB10.41437793
124CSNK1G30.41436280
125CSNK1G20.40956145
126PRKG10.39856632
127PIK3CG0.39313626
128PRKCA0.38372901
129TBK10.38372473
130PLK40.38244735
131GRK70.36420698
132NEK20.35427333
133LYN0.34443608
134IGF1R0.33762810
135GRK50.33591248
136PRKCE0.33513483
137CDK90.31864745
138CHUK0.29536811
139MAPK40.28466518
140CDK70.27463967
141CAMK2D0.26831070
142ERBB40.25407897
143TGFBR20.25273810
144JAK30.25150923
145ILK0.24535492
146CAMKK10.24226565
147AURKB0.24101623
148KIT0.23864392
149MAPK70.23272487
150CSNK2A10.23142619
151MAPK130.23134480
152RPS6KB10.22802941
153MET0.22602317
154PRKCI0.20766203
155ABL10.20461756
156CSNK1G10.19725716

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.23406395
2ECM-receptor interaction_Homo sapiens_hsa045124.11869405
3Protein digestion and absorption_Homo sapiens_hsa049743.46991325
4Linoleic acid metabolism_Homo sapiens_hsa005912.96313053
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.75035350
6Sphingolipid metabolism_Homo sapiens_hsa006002.72463717
7Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.51709418
8Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.41928528
9Fat digestion and absorption_Homo sapiens_hsa049752.36627027
10Ether lipid metabolism_Homo sapiens_hsa005652.24684594
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.23117186
12Phototransduction_Homo sapiens_hsa047442.10147095
13Chemical carcinogenesis_Homo sapiens_hsa052042.09677518
14Protein export_Homo sapiens_hsa030602.06978831
15Steroid hormone biosynthesis_Homo sapiens_hsa001401.99084725
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.97518541
17Asthma_Homo sapiens_hsa053101.96788150
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.96586997
19Malaria_Homo sapiens_hsa051441.94918777
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.93623199
21Retinol metabolism_Homo sapiens_hsa008301.91550260
22Propanoate metabolism_Homo sapiens_hsa006401.90397513
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.82015274
24Focal adhesion_Homo sapiens_hsa045101.80900395
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.77552958
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.71947971
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.70902560
28Caffeine metabolism_Homo sapiens_hsa002321.70139587
29Vitamin B6 metabolism_Homo sapiens_hsa007501.69584307
30Carbohydrate digestion and absorption_Homo sapiens_hsa049731.68734099
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.67575115
32Mineral absorption_Homo sapiens_hsa049781.58197951
33* Olfactory transduction_Homo sapiens_hsa047401.47016968
34Butanoate metabolism_Homo sapiens_hsa006501.46573018
35Peroxisome_Homo sapiens_hsa041461.45696922
36* Salivary secretion_Homo sapiens_hsa049701.43607381
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41664162
38Ribosome_Homo sapiens_hsa030101.39658019
39Arachidonic acid metabolism_Homo sapiens_hsa005901.38102067
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.36012961
41Taste transduction_Homo sapiens_hsa047421.35950892
42Other glycan degradation_Homo sapiens_hsa005111.35333948
43Glycerophospholipid metabolism_Homo sapiens_hsa005641.35295804
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.35126739
45PI3K-Akt signaling pathway_Homo sapiens_hsa041511.33898274
46Sulfur metabolism_Homo sapiens_hsa009201.29271671
47Vitamin digestion and absorption_Homo sapiens_hsa049771.27024088
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.23955503
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.23165719
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.21449664
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19306880
52TGF-beta signaling pathway_Homo sapiens_hsa043501.19266688
53* Renin secretion_Homo sapiens_hsa049241.15289583
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13578098
55Starch and sucrose metabolism_Homo sapiens_hsa005001.11596265
56Renin-angiotensin system_Homo sapiens_hsa046141.11289903
57N-Glycan biosynthesis_Homo sapiens_hsa005101.08681145
58Tryptophan metabolism_Homo sapiens_hsa003801.08508343
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06619224
60Histidine metabolism_Homo sapiens_hsa003401.06416134
61Galactose metabolism_Homo sapiens_hsa000521.03255181
62Folate biosynthesis_Homo sapiens_hsa007901.02785166
63Autoimmune thyroid disease_Homo sapiens_hsa053201.00849100
64Hematopoietic cell lineage_Homo sapiens_hsa046400.99823808
65Basal transcription factors_Homo sapiens_hsa030220.98974149
66Type I diabetes mellitus_Homo sapiens_hsa049400.97620237
67Pancreatic secretion_Homo sapiens_hsa049720.97360348
68RNA polymerase_Homo sapiens_hsa030200.97156463
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.96117654
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94192018
71Primary immunodeficiency_Homo sapiens_hsa053400.92908261
72Thyroid cancer_Homo sapiens_hsa052160.91498365
73Glycerolipid metabolism_Homo sapiens_hsa005610.90521791
74Purine metabolism_Homo sapiens_hsa002300.89556950
75Ovarian steroidogenesis_Homo sapiens_hsa049130.88341691
76Nicotine addiction_Homo sapiens_hsa050330.87688147
77ABC transporters_Homo sapiens_hsa020100.86411211
78Steroid biosynthesis_Homo sapiens_hsa001000.86119710
79Proteoglycans in cancer_Homo sapiens_hsa052050.85408304
80Shigellosis_Homo sapiens_hsa051310.84999985
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80856624
82Dorso-ventral axis formation_Homo sapiens_hsa043200.80351189
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79570721
84Vibrio cholerae infection_Homo sapiens_hsa051100.78723043
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77273506
86Phagosome_Homo sapiens_hsa041450.76797557
87One carbon pool by folate_Homo sapiens_hsa006700.76639519
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74646132
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.74483576
90Pyrimidine metabolism_Homo sapiens_hsa002400.74369683
91p53 signaling pathway_Homo sapiens_hsa041150.72045277
92Salmonella infection_Homo sapiens_hsa051320.70982831
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70847739
94TNF signaling pathway_Homo sapiens_hsa046680.70749120
95Melanoma_Homo sapiens_hsa052180.69913238
96Bladder cancer_Homo sapiens_hsa052190.69683143
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69388145
98Hepatitis B_Homo sapiens_hsa051610.68910061
99Selenocompound metabolism_Homo sapiens_hsa004500.68063905
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67338981
101* Long-term depression_Homo sapiens_hsa047300.67084362
102RNA degradation_Homo sapiens_hsa030180.66074151
103Hippo signaling pathway_Homo sapiens_hsa043900.64747904
104Fatty acid elongation_Homo sapiens_hsa000620.63971502
105Apoptosis_Homo sapiens_hsa042100.63858429
106Fatty acid degradation_Homo sapiens_hsa000710.63482661
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63073410
108NF-kappa B signaling pathway_Homo sapiens_hsa040640.62027328
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61719060
110* Circadian entrainment_Homo sapiens_hsa047130.61311293
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.60608059
112MicroRNAs in cancer_Homo sapiens_hsa052060.59950659
113Small cell lung cancer_Homo sapiens_hsa052220.59856620
114Wnt signaling pathway_Homo sapiens_hsa043100.59434882
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59330880
116African trypanosomiasis_Homo sapiens_hsa051430.57742326
117Nitrogen metabolism_Homo sapiens_hsa009100.57731425
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.56518770
119Proteasome_Homo sapiens_hsa030500.55505314
120Metabolic pathways_Homo sapiens_hsa011000.54813626
121Allograft rejection_Homo sapiens_hsa053300.54557007
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53751446
123Cell cycle_Homo sapiens_hsa041100.53216850
124Nucleotide excision repair_Homo sapiens_hsa034200.52828654
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51971308
126Fanconi anemia pathway_Homo sapiens_hsa034600.51721217
127Prostate cancer_Homo sapiens_hsa052150.49961937
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.48109024
129Legionellosis_Homo sapiens_hsa051340.46847844
130Cocaine addiction_Homo sapiens_hsa050300.46762963
131Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46383817
132Measles_Homo sapiens_hsa051620.45948328
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45764726
134Leishmaniasis_Homo sapiens_hsa051400.45137461
135Jak-STAT signaling pathway_Homo sapiens_hsa046300.43767537
136Basal cell carcinoma_Homo sapiens_hsa052170.43217909
137* Platelet activation_Homo sapiens_hsa046110.43206742
138Rheumatoid arthritis_Homo sapiens_hsa053230.42491596
139Bile secretion_Homo sapiens_hsa049760.42258790
140Adherens junction_Homo sapiens_hsa045200.42156430
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41723441
142Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40936315
143Base excision repair_Homo sapiens_hsa034100.40677487
144Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40139726
145Oxytocin signaling pathway_Homo sapiens_hsa049210.40133159
146Glutamatergic synapse_Homo sapiens_hsa047240.39138115
147Serotonergic synapse_Homo sapiens_hsa047260.38919366
148Tyrosine metabolism_Homo sapiens_hsa003500.37945840
149PPAR signaling pathway_Homo sapiens_hsa033200.37550884
150Insulin secretion_Homo sapiens_hsa049110.37192901
151Antigen processing and presentation_Homo sapiens_hsa046120.36700627
152Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35569596
153HTLV-I infection_Homo sapiens_hsa051660.35244280
154Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35124282
155Pathways in cancer_Homo sapiens_hsa052000.33794208
156Dilated cardiomyopathy_Homo sapiens_hsa054140.33050194
157Leukocyte transendothelial migration_Homo sapiens_hsa046700.33005587
158Toll-like receptor signaling pathway_Homo sapiens_hsa046200.31790222
159Calcium signaling pathway_Homo sapiens_hsa040200.31683904
160Hedgehog signaling pathway_Homo sapiens_hsa043400.31338472
161Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31056686
162Graft-versus-host disease_Homo sapiens_hsa053320.29695769
163Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.28777913
164Homologous recombination_Homo sapiens_hsa034400.28748778
165Glutathione metabolism_Homo sapiens_hsa004800.28712296

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