Rank | Gene Set | Z-score |
---|---|---|
1 | ribosomal small subunit assembly (GO:0000028) | 7.64635645 |
2 | viral transcription (GO:0019083) | 6.23838330 |
3 | translational termination (GO:0006415) | 6.05236775 |
4 | ribosomal small subunit biogenesis (GO:0042274) | 5.99148238 |
5 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 5.56537366 |
6 | cotranslational protein targeting to membrane (GO:0006613) | 5.51300438 |
7 | ATP synthesis coupled proton transport (GO:0015986) | 5.44702499 |
8 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.44702499 |
9 | protein targeting to ER (GO:0045047) | 5.42525289 |
10 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.35446014 |
11 | translational elongation (GO:0006414) | 5.18962719 |
12 | protein localization to endoplasmic reticulum (GO:0070972) | 5.18054845 |
13 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 5.10945200 |
14 | pyrimidine nucleobase catabolic process (GO:0006208) | 5.06018578 |
15 | viral life cycle (GO:0019058) | 4.82191576 |
16 | cellular protein complex disassembly (GO:0043624) | 4.74894164 |
17 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.64544564 |
18 | maturation of SSU-rRNA (GO:0030490) | 4.61765527 |
19 | protein complex disassembly (GO:0043241) | 4.33655615 |
20 | cullin deneddylation (GO:0010388) | 4.23175260 |
21 | oxidative phosphorylation (GO:0006119) | 4.22447856 |
22 | macromolecular complex disassembly (GO:0032984) | 4.17613979 |
23 | respiratory chain complex IV assembly (GO:0008535) | 4.02508679 |
24 | translational initiation (GO:0006413) | 4.00191146 |
25 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.96837970 |
26 | DNA double-strand break processing (GO:0000729) | 3.95890184 |
27 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.93291700 |
28 | protein deneddylation (GO:0000338) | 3.87791565 |
29 | proteasome assembly (GO:0043248) | 3.86202370 |
30 | urogenital system development (GO:0001655) | 3.84529803 |
31 | respiratory electron transport chain (GO:0022904) | 3.80397377 |
32 | DNA deamination (GO:0045006) | 3.78096004 |
33 | fat-soluble vitamin biosynthetic process (GO:0042362) | 3.76854093 |
34 | chromatin remodeling at centromere (GO:0031055) | 3.75301318 |
35 | electron transport chain (GO:0022900) | 3.72339762 |
36 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.65361213 |
37 | protein complex biogenesis (GO:0070271) | 3.61986864 |
38 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.61700820 |
39 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.61700820 |
40 | CENP-A containing nucleosome assembly (GO:0034080) | 3.61076842 |
41 | nucleobase catabolic process (GO:0046113) | 3.53215859 |
42 | translation (GO:0006412) | 3.50567883 |
43 | platelet dense granule organization (GO:0060155) | 3.48917367 |
44 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 3.44451479 |
45 | deoxyribose phosphate biosynthetic process (GO:0046385) | 3.44451479 |
46 | protein targeting to membrane (GO:0006612) | 3.43142652 |
47 | NADH dehydrogenase complex assembly (GO:0010257) | 3.42294364 |
48 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.42294364 |
49 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.42294364 |
50 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.39479404 |
51 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.36932481 |
52 | establishment of integrated proviral latency (GO:0075713) | 3.32128120 |
53 | de novo posttranslational protein folding (GO:0051084) | 3.25598022 |
54 | DNA damage response, detection of DNA damage (GO:0042769) | 3.22621488 |
55 | deoxyribonucleotide biosynthetic process (GO:0009263) | 3.21565763 |
56 | histone exchange (GO:0043486) | 3.20971886 |
57 | chaperone-mediated protein transport (GO:0072321) | 3.18631227 |
58 | cytochrome complex assembly (GO:0017004) | 3.18172148 |
59 | histone H2A acetylation (GO:0043968) | 3.16655226 |
60 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.13518886 |
61 | ribosomal large subunit biogenesis (GO:0042273) | 3.13306937 |
62 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.12785447 |
63 | mRNA catabolic process (GO:0006402) | 3.11863482 |
64 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.11432110 |
65 | protein neddylation (GO:0045116) | 3.09165047 |
66 | replication fork processing (GO:0031297) | 3.09087489 |
67 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.06768505 |
68 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.02496077 |
69 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.02496077 |
70 | de novo protein folding (GO:0006458) | 3.01922312 |
71 | DNA strand elongation (GO:0022616) | 2.99708739 |
72 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.98049045 |
73 | aerobic respiration (GO:0009060) | 2.97740387 |
74 | response to pheromone (GO:0019236) | 2.97197559 |
75 | spinal cord association neuron differentiation (GO:0021527) | 2.95523368 |
76 | ubiquinone metabolic process (GO:0006743) | 2.94495771 |
77 | kinetochore assembly (GO:0051382) | 2.93902381 |
78 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.92440632 |
79 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.91731723 |
80 | kinetochore organization (GO:0051383) | 2.90961374 |
81 | protein-cofactor linkage (GO:0018065) | 2.89162306 |
82 | negative regulation of RNA splicing (GO:0033119) | 2.88822089 |
83 | cranial nerve morphogenesis (GO:0021602) | 2.86320544 |
84 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.85787897 |
85 | facial nerve structural organization (GO:0021612) | 2.85732829 |
86 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.84692749 |
87 | negative regulation of microtubule polymerization (GO:0031115) | 2.83041819 |
88 | RNA catabolic process (GO:0006401) | 2.81620840 |
89 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.79316294 |
90 | protein K11-linked ubiquitination (GO:0070979) | 2.78381541 |
91 | iron-sulfur cluster assembly (GO:0016226) | 2.78213009 |
92 | metallo-sulfur cluster assembly (GO:0031163) | 2.78213009 |
93 | intraciliary transport (GO:0042073) | 2.77602543 |
94 | telomere maintenance via recombination (GO:0000722) | 2.77237593 |
95 | DNA ligation (GO:0006266) | 2.76165531 |
96 | synapsis (GO:0007129) | 2.76141325 |
97 | ubiquinone biosynthetic process (GO:0006744) | 2.76014711 |
98 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 2.75478578 |
99 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.74519421 |
100 | G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199 | 2.73990524 |
101 | negative regulation of ligase activity (GO:0051352) | 2.73852725 |
102 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.73852725 |
103 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.72781319 |
104 | positive regulation of hematopoietic progenitor cell differentiation (GO:1901534) | 2.71250729 |
105 | resolution of meiotic recombination intermediates (GO:0000712) | 2.70240189 |
106 | endosome to pigment granule transport (GO:0043485) | 2.70012973 |
107 | endosome to melanosome transport (GO:0035646) | 2.70012973 |
108 | peptidyl-arginine omega-N-methylation (GO:0035247) | 2.70005925 |
109 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.69465438 |
110 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 2.67714215 |
111 | histone mRNA metabolic process (GO:0008334) | 2.67549514 |
112 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 2.67183060 |
113 | isotype switching (GO:0045190) | 2.67183060 |
114 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.67183060 |
115 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.67066317 |
116 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.66983140 |
117 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.66983140 |
118 | retinal ganglion cell axon guidance (GO:0031290) | 2.66124484 |
119 | pyrimidine nucleobase metabolic process (GO:0006206) | 2.66077376 |
120 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.65714465 |
121 | ATP biosynthetic process (GO:0006754) | 2.65149781 |
122 | regulation of mitochondrial translation (GO:0070129) | 2.64994806 |
123 | protein K6-linked ubiquitination (GO:0085020) | 2.63455633 |
124 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.62062976 |
125 | protein polyglutamylation (GO:0018095) | 2.61573509 |
126 | pseudouridine synthesis (GO:0001522) | 2.61212216 |
127 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 2.61092693 |
128 | positive regulation of receptor biosynthetic process (GO:0010870) | 2.60662805 |
129 | positive regulation of mitochondrial fission (GO:0090141) | 2.60584919 |
130 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.58417885 |
131 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.58417885 |
132 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.58417885 |
133 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.58381305 |
134 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 2.58004090 |
135 | DNA replication-independent nucleosome organization (GO:0034724) | 2.57956567 |
136 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.57956567 |
137 | mitotic metaphase plate congression (GO:0007080) | 2.57695066 |
138 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.57044794 |
139 | response to misfolded protein (GO:0051788) | 2.56763042 |
140 | termination of RNA polymerase III transcription (GO:0006386) | 2.56446867 |
141 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.56446867 |
142 | aldehyde catabolic process (GO:0046185) | 2.56387349 |
143 | spindle checkpoint (GO:0031577) | 2.54959959 |
144 | centriole replication (GO:0007099) | 2.54370741 |
145 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 2.54093370 |
146 | negative regulation of DNA recombination (GO:0045910) | 2.53194474 |
147 | mitotic spindle checkpoint (GO:0071174) | 2.51130072 |
148 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 2.50213102 |
149 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 2.50213102 |
150 | protein targeting to mitochondrion (GO:0006626) | 2.49194684 |
151 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 2.47948478 |
152 | negative regulation of sister chromatid segregation (GO:0033046) | 2.47948478 |
153 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 2.47948478 |
154 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 2.47948478 |
155 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 2.47948478 |
156 | inner mitochondrial membrane organization (GO:0007007) | 2.45236807 |
157 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 2.45126562 |
158 | metaphase plate congression (GO:0051310) | 2.44524926 |
159 | organelle disassembly (GO:1903008) | 2.44447539 |
160 | branched-chain amino acid catabolic process (GO:0009083) | 2.44033039 |
161 | protein localization to mitochondrion (GO:0070585) | 2.43552971 |
162 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 2.43146656 |
163 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 2.42809400 |
164 | positive regulation of ligase activity (GO:0051351) | 2.41388485 |
165 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 2.40738155 |
166 | recombinational repair (GO:0000725) | 2.40522215 |
167 | negative regulation of chromosome segregation (GO:0051985) | 2.40187979 |
168 | base-excision repair, AP site formation (GO:0006285) | 2.40181336 |
169 | peptidyl-histidine modification (GO:0018202) | 2.39251177 |
Rank | Gene Set | Z-score |
---|---|---|
1 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 5.44321138 |
2 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 4.34167052 |
3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.09623104 |
4 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 4.03515017 |
5 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.89609056 |
6 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.72635926 |
7 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.57509051 |
8 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.54453038 |
9 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.28280132 |
10 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.09545638 |
11 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.81068305 |
12 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.80753332 |
13 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.77544885 |
14 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.73540465 |
15 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.72797150 |
16 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.66982663 |
17 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.63840956 |
18 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.58258783 |
19 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.53606569 |
20 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.32203962 |
21 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.30212254 |
22 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.30166151 |
23 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.28887992 |
24 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.26305787 |
25 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.25767993 |
26 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 2.18236638 |
27 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.16863502 |
28 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.16785950 |
29 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.11921229 |
30 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.08992391 |
31 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.05621893 |
32 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.03626066 |
33 | VDR_22108803_ChIP-Seq_LS180_Human | 2.03219650 |
34 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.01151989 |
35 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.99947055 |
36 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.99944581 |
37 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.94165995 |
38 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.93654206 |
39 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.93147351 |
40 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.85461934 |
41 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.79925395 |
42 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.78592646 |
43 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.78089551 |
44 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.77616555 |
45 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.74629212 |
46 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.73767071 |
47 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.73716700 |
48 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.73174841 |
49 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.70230035 |
50 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.69060927 |
51 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.66974096 |
52 | P300_19829295_ChIP-Seq_ESCs_Human | 1.65518201 |
53 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.64800991 |
54 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.64704395 |
55 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.63654180 |
56 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.63508721 |
57 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.61517341 |
58 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.59171535 |
59 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.58573879 |
60 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.53063025 |
61 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.51890667 |
62 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.49025396 |
63 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.47507218 |
64 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.47276173 |
65 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.45259963 |
66 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.44660211 |
67 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.42323666 |
68 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.40816057 |
69 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.39454438 |
70 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.37072991 |
71 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.36335732 |
72 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.35830286 |
73 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.35389922 |
74 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.34504538 |
75 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.34367800 |
76 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.34289664 |
77 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.33308882 |
78 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.31952176 |
79 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.28250888 |
80 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.27222602 |
81 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.26796936 |
82 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.26000397 |
83 | * RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.25452202 |
84 | FUS_26573619_Chip-Seq_HEK293_Human | 1.25292459 |
85 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.24271981 |
86 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.23553853 |
87 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.22671457 |
88 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.21923837 |
89 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.21231310 |
90 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.19667838 |
91 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.18908499 |
92 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.17959056 |
93 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.17947760 |
94 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 1.16515714 |
95 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.15832750 |
96 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.14732918 |
97 | EWS_26573619_Chip-Seq_HEK293_Human | 1.14460862 |
98 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.13848019 |
99 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.12640345 |
100 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.12048466 |
101 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.12048466 |
102 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.11969572 |
103 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.10987844 |
104 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.10787740 |
105 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.10162245 |
106 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.09911793 |
107 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.09319613 |
108 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.08839887 |
109 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.08673888 |
110 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.08420332 |
111 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.06819219 |
112 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.06280368 |
113 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.04782674 |
114 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.03591596 |
115 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.01998077 |
116 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.01785394 |
117 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.01493044 |
118 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.01400241 |
119 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.00879749 |
120 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.00166501 |
121 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.00166501 |
122 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.97891209 |
123 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.96750381 |
124 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.95798149 |
125 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.94893186 |
126 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.94684548 |
127 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 0.94325091 |
128 | SMAD4_21799915_ChIP-Seq_A2780_Human | 0.94021878 |
129 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.94002184 |
130 | AR_21909140_ChIP-Seq_LNCAP_Human | 0.93395864 |
131 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.91686132 |
132 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.91113915 |
133 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 0.90547240 |
134 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.89731991 |
135 | EZH2_22144423_ChIP-Seq_EOC_Human | 0.89245938 |
136 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.89117925 |
137 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 0.88357579 |
138 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.87972570 |
139 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.87777511 |
140 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.82301765 |
141 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.81325559 |
142 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.80957206 |
143 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.79594475 |
144 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.77267198 |
145 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.76819970 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0009379_abnormal_foot_pigmentation | 5.27011060 |
2 | MP0003122_maternal_imprinting | 4.36623502 |
3 | MP0002938_white_spotting | 3.89692419 |
4 | MP0005083_abnormal_biliary_tract | 3.33034478 |
5 | MP0010030_abnormal_orbit_morphology | 3.10454945 |
6 | MP0003880_abnormal_central_pattern | 2.91402209 |
7 | MP0006054_spinal_hemorrhage | 2.79623842 |
8 | MP0002102_abnormal_ear_morphology | 2.46908822 |
9 | MP0000566_synostosis | 2.45345794 |
10 | MP0001529_abnormal_vocalization | 2.41572059 |
11 | MP0003942_abnormal_urinary_system | 2.36688667 |
12 | MP0009697_abnormal_copulation | 2.33900636 |
13 | MP0003121_genomic_imprinting | 2.32769016 |
14 | MP0004145_abnormal_muscle_electrophysio | 2.28307540 |
15 | MP0006276_abnormal_autonomic_nervous | 2.24494791 |
16 | MP0008877_abnormal_DNA_methylation | 2.18290103 |
17 | MP0000372_irregular_coat_pigmentation | 2.13465026 |
18 | MP0009053_abnormal_anal_canal | 2.11334984 |
19 | MP0003011_delayed_dark_adaptation | 2.08307718 |
20 | MP0010094_abnormal_chromosome_stability | 2.06552142 |
21 | MP0003123_paternal_imprinting | 2.06143547 |
22 | MP0008789_abnormal_olfactory_epithelium | 2.00951933 |
23 | MP0002837_dystrophic_cardiac_calcinosis | 1.99177488 |
24 | MP0005174_abnormal_tail_pigmentation | 1.98648141 |
25 | MP0000537_abnormal_urethra_morphology | 1.97095732 |
26 | MP0003315_abnormal_perineum_morphology | 1.92371456 |
27 | MP0002751_abnormal_autonomic_nervous | 1.74704413 |
28 | MP0000749_muscle_degeneration | 1.71899904 |
29 | MP0009046_muscle_twitch | 1.71619817 |
30 | MP0001293_anophthalmia | 1.70685951 |
31 | MP0002638_abnormal_pupillary_reflex | 1.67428601 |
32 | MP0008007_abnormal_cellular_replicative | 1.65485270 |
33 | MP0003646_muscle_fatigue | 1.65104662 |
34 | * MP0000049_abnormal_middle_ear | 1.64647696 |
35 | MP0003718_maternal_effect | 1.64642852 |
36 | MP0005379_endocrine/exocrine_gland_phen | 1.63988048 |
37 | MP0005423_abnormal_somatic_nervous | 1.63741345 |
38 | MP0003693_abnormal_embryo_hatching | 1.60986732 |
39 | MP0002282_abnormal_trachea_morphology | 1.54213506 |
40 | MP0008995_early_reproductive_senescence | 1.54089701 |
41 | MP0004215_abnormal_myocardial_fiber | 1.52909405 |
42 | MP0003385_abnormal_body_wall | 1.51997856 |
43 | MP0009384_cardiac_valve_regurgitation | 1.50220069 |
44 | MP0006072_abnormal_retinal_apoptosis | 1.49970559 |
45 | MP0005645_abnormal_hypothalamus_physiol | 1.48958306 |
46 | MP0005551_abnormal_eye_electrophysiolog | 1.46726602 |
47 | MP0005084_abnormal_gallbladder_morpholo | 1.45277798 |
48 | MP0001188_hyperpigmentation | 1.43548165 |
49 | MP0003567_abnormal_fetal_cardiomyocyte | 1.39521726 |
50 | MP0001485_abnormal_pinna_reflex | 1.36804874 |
51 | MP0000631_abnormal_neuroendocrine_gland | 1.36344873 |
52 | MP0004142_abnormal_muscle_tone | 1.32907233 |
53 | MP0005248_abnormal_Harderian_gland | 1.32907122 |
54 | MP0009250_abnormal_appendicular_skeleto | 1.32581994 |
55 | MP0003787_abnormal_imprinting | 1.31792205 |
56 | MP0001905_abnormal_dopamine_level | 1.30919865 |
57 | MP0000778_abnormal_nervous_system | 1.28665139 |
58 | MP0002163_abnormal_gland_morphology | 1.28549827 |
59 | MP0003937_abnormal_limbs/digits/tail_de | 1.27150275 |
60 | MP0002139_abnormal_hepatobiliary_system | 1.27149355 |
61 | MP0005187_abnormal_penis_morphology | 1.27089470 |
62 | MP0002132_abnormal_respiratory_system | 1.26788410 |
63 | MP0005408_hypopigmentation | 1.23868346 |
64 | MP0003136_yellow_coat_color | 1.23456377 |
65 | MP0002822_catalepsy | 1.22155512 |
66 | MP0005253_abnormal_eye_physiology | 1.21612888 |
67 | MP0002160_abnormal_reproductive_system | 1.21534265 |
68 | MP0001986_abnormal_taste_sensitivity | 1.20698540 |
69 | MP0005646_abnormal_pituitary_gland | 1.18182709 |
70 | MP0004133_heterotaxia | 1.16790519 |
71 | MP0002272_abnormal_nervous_system | 1.14822607 |
72 | MP0000015_abnormal_ear_pigmentation | 1.13911410 |
73 | MP0002234_abnormal_pharynx_morphology | 1.13679306 |
74 | MP0002210_abnormal_sex_determination | 1.12984545 |
75 | MP0001929_abnormal_gametogenesis | 1.12712032 |
76 | MP0001879_abnormal_lymphatic_vessel | 1.12460332 |
77 | MP0006036_abnormal_mitochondrial_physio | 1.11734896 |
78 | MP0005499_abnormal_olfactory_system | 1.09867037 |
79 | MP0005394_taste/olfaction_phenotype | 1.09867037 |
80 | MP0002095_abnormal_skin_pigmentation | 1.09786190 |
81 | MP0002932_abnormal_joint_morphology | 1.09197022 |
82 | MP0001324_abnormal_eye_pigmentation | 1.09106494 |
83 | MP0006292_abnormal_olfactory_placode | 1.07502176 |
84 | MP0000534_abnormal_ureter_morphology | 1.07283031 |
85 | MP0003786_premature_aging | 1.05901799 |
86 | MP0003137_abnormal_impulse_conducting | 1.05295458 |
87 | MP0000569_abnormal_digit_pigmentation | 1.03599370 |
88 | MP0003111_abnormal_nucleus_morphology | 1.03219242 |
89 | MP0001486_abnormal_startle_reflex | 1.02621135 |
90 | MP0002736_abnormal_nociception_after | 1.00591717 |
91 | MP0001984_abnormal_olfaction | 0.98913893 |
92 | MP0000538_abnormal_urinary_bladder | 0.95580775 |
93 | MP0000653_abnormal_sex_gland | 0.95336479 |
94 | MP0005365_abnormal_bile_salt | 0.94571542 |
95 | MP0002249_abnormal_larynx_morphology | 0.92061187 |
96 | MP0004270_analgesia | 0.90523496 |
97 | MP0009745_abnormal_behavioral_response | 0.89980078 |
98 | MP0000647_abnormal_sebaceous_gland | 0.88859259 |
99 | MP0001145_abnormal_male_reproductive | 0.88247965 |
100 | MP0000462_abnormal_digestive_system | 0.87549534 |
101 | MP0003943_abnormal_hepatobiliary_system | 0.86525449 |
102 | MP0003698_abnormal_male_reproductive | 0.86454984 |
103 | MP0002752_abnormal_somatic_nervous | 0.86426190 |
104 | MP0002067_abnormal_sensory_capabilities | 0.86334937 |
105 | MP0005220_abnormal_exocrine_pancreas | 0.84156459 |
106 | MP0004233_abnormal_muscle_weight | 0.84078135 |
107 | MP0001299_abnormal_eye_distance/ | 0.83615189 |
108 | MP0002184_abnormal_innervation | 0.83288949 |
109 | MP0002653_abnormal_ependyma_morphology | 0.83152695 |
110 | MP0004957_abnormal_blastocyst_morpholog | 0.82629459 |
111 | MP0006035_abnormal_mitochondrial_morpho | 0.82215102 |
112 | MP0003221_abnormal_cardiomyocyte_apopto | 0.81874354 |
113 | MP0000026_abnormal_inner_ear | 0.81816415 |
114 | MP0001286_abnormal_eye_development | 0.80689112 |
115 | MP0004924_abnormal_behavior | 0.79162113 |
116 | MP0005386_behavior/neurological_phenoty | 0.79162113 |
117 | MP0004808_abnormal_hematopoietic_stem | 0.78560871 |
118 | MP0003755_abnormal_palate_morphology | 0.78541215 |
119 | MP0008932_abnormal_embryonic_tissue | 0.78434525 |
120 | MP0005075_abnormal_melanosome_morpholog | 0.78272262 |
121 | MP0005197_abnormal_uvea_morphology | 0.75584268 |
122 | MP0002106_abnormal_muscle_physiology | 0.75224179 |
123 | MP0003183_abnormal_peptide_metabolism | 0.74491214 |
124 | MP0001764_abnormal_homeostasis | 0.74339129 |
125 | MP0005171_absent_coat_pigmentation | 0.74318611 |
126 | MP0005391_vision/eye_phenotype | 0.73263080 |
127 | MP0005195_abnormal_posterior_eye | 0.73191548 |
128 | MP0003119_abnormal_digestive_system | 0.72481762 |
129 | MP0005266_abnormal_metabolism | 0.72056693 |
130 | MP0002127_abnormal_cardiovascular_syste | 0.71331442 |
131 | * MP0002177_abnormal_outer_ear | 0.70589387 |
132 | MP0001968_abnormal_touch/_nociception | 0.70546358 |
133 | * MP0002233_abnormal_nose_morphology | 0.68729667 |
134 | MP0008058_abnormal_DNA_repair | 0.68535751 |
135 | MP0001727_abnormal_embryo_implantation | 0.68435977 |
136 | MP0004147_increased_porphyrin_level | 0.67788336 |
137 | MP0005377_hearing/vestibular/ear_phenot | 0.67457301 |
138 | MP0003878_abnormal_ear_physiology | 0.67457301 |
139 | MP0003959_abnormal_lean_body | 0.67130522 |
140 | MP0002557_abnormal_social/conspecific_i | 0.66229238 |
141 | MP0010386_abnormal_urinary_bladder | 0.64530465 |
142 | MP0003115_abnormal_respiratory_system | 0.63590955 |
143 | MP0003186_abnormal_redox_activity | 0.63394592 |
144 | MP0003077_abnormal_cell_cycle | 0.63131362 |
145 | MP0010368_abnormal_lymphatic_system | 0.61051208 |
146 | MP0000751_myopathy | 0.60746705 |
147 | MP0003890_abnormal_embryonic-extraembry | 0.58582811 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.61872208 |
2 | Mitochondrial inheritance (HP:0001427) | 4.35161739 |
3 | Abnormal number of erythroid precursors (HP:0012131) | 4.29507975 |
4 | Acute necrotizing encephalopathy (HP:0006965) | 4.15371768 |
5 | Increased hepatocellular lipid droplets (HP:0006565) | 4.06781814 |
6 | Lipid accumulation in hepatocytes (HP:0006561) | 3.99372228 |
7 | Increased CSF lactate (HP:0002490) | 3.89144135 |
8 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.84862017 |
9 | Hepatocellular necrosis (HP:0001404) | 3.83822218 |
10 | Reticulocytopenia (HP:0001896) | 3.75282680 |
11 | Hypothermia (HP:0002045) | 3.70629804 |
12 | Abnormality of the labia minora (HP:0012880) | 3.66266315 |
13 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.56094152 |
14 | Hepatic necrosis (HP:0002605) | 3.51979768 |
15 | Renal Fanconi syndrome (HP:0001994) | 3.50089768 |
16 | Colon cancer (HP:0003003) | 3.48158946 |
17 | Acute encephalopathy (HP:0006846) | 3.40129842 |
18 | Molar tooth sign on MRI (HP:0002419) | 3.38132539 |
19 | Abnormality of midbrain morphology (HP:0002418) | 3.38132539 |
20 | Progressive macrocephaly (HP:0004481) | 3.36242587 |
21 | Increased intramyocellular lipid droplets (HP:0012240) | 3.20675597 |
22 | Increased serum pyruvate (HP:0003542) | 3.18940520 |
23 | Abnormality of glycolysis (HP:0004366) | 3.18940520 |
24 | Hyperglycinemia (HP:0002154) | 3.05526647 |
25 | Increased muscle lipid content (HP:0009058) | 2.97958880 |
26 | Aplastic anemia (HP:0001915) | 2.97755524 |
27 | Pallor (HP:0000980) | 2.81248244 |
28 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.80449551 |
29 | Wide cranial sutures (HP:0010537) | 2.79555099 |
30 | Macrocytic anemia (HP:0001972) | 2.73869112 |
31 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.68112645 |
32 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.68112645 |
33 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.64141660 |
34 | Nephronophthisis (HP:0000090) | 2.63615498 |
35 | Respiratory difficulties (HP:0002880) | 2.63384390 |
36 | Intestinal atresia (HP:0011100) | 2.60253920 |
37 | Gait imbalance (HP:0002141) | 2.59740114 |
38 | Exercise intolerance (HP:0003546) | 2.53018403 |
39 | Increased serum lactate (HP:0002151) | 2.52351048 |
40 | Exercise-induced muscle cramps (HP:0003710) | 2.47447376 |
41 | Chromsome breakage (HP:0040012) | 2.46325024 |
42 | Abnormal biliary tract physiology (HP:0012439) | 2.46170239 |
43 | Bile duct proliferation (HP:0001408) | 2.46170239 |
44 | Exertional dyspnea (HP:0002875) | 2.45975167 |
45 | Hypoplastic left heart (HP:0004383) | 2.45804767 |
46 | Thin bony cortex (HP:0002753) | 2.44848692 |
47 | True hermaphroditism (HP:0010459) | 2.44718863 |
48 | Severe visual impairment (HP:0001141) | 2.44684555 |
49 | Short middle phalanx of the 5th finger (HP:0004220) | 2.44267879 |
50 | Lactic acidosis (HP:0003128) | 2.44263472 |
51 | Cerebral edema (HP:0002181) | 2.42085774 |
52 | Supernumerary spleens (HP:0009799) | 2.39395117 |
53 | Meckel diverticulum (HP:0002245) | 2.37513398 |
54 | Retinal dysplasia (HP:0007973) | 2.36310966 |
55 | Renal cortical cysts (HP:0000803) | 2.35931104 |
56 | Abnormality of the ileum (HP:0001549) | 2.35809851 |
57 | Medial flaring of the eyebrow (HP:0010747) | 2.35651754 |
58 | Microvesicular hepatic steatosis (HP:0001414) | 2.33843265 |
59 | Nephrogenic diabetes insipidus (HP:0009806) | 2.31705516 |
60 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.31396301 |
61 | Lissencephaly (HP:0001339) | 2.30521104 |
62 | Congenital primary aphakia (HP:0007707) | 2.26924592 |
63 | Bifid tongue (HP:0010297) | 2.26045360 |
64 | Rimmed vacuoles (HP:0003805) | 2.24541589 |
65 | Pheochromocytoma (HP:0002666) | 2.21869926 |
66 | 11 pairs of ribs (HP:0000878) | 2.21389251 |
67 | Neoplasm of the adrenal gland (HP:0100631) | 2.17385762 |
68 | Cortical dysplasia (HP:0002539) | 2.16084116 |
69 | Short 4th metacarpal (HP:0010044) | 2.12773010 |
70 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.12773010 |
71 | Type I transferrin isoform profile (HP:0003642) | 2.11794328 |
72 | Neuroendocrine neoplasm (HP:0100634) | 2.10599096 |
73 | Abnormality of the renal medulla (HP:0100957) | 2.09840663 |
74 | Polyphagia (HP:0002591) | 2.08931883 |
75 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.08898569 |
76 | Methylmalonic acidemia (HP:0002912) | 2.07862422 |
77 | Glycosuria (HP:0003076) | 2.07416326 |
78 | Abnormality of urine glucose concentration (HP:0011016) | 2.07416326 |
79 | Abnormality of renal resorption (HP:0011038) | 2.07057080 |
80 | Type 2 muscle fiber atrophy (HP:0003554) | 2.06821924 |
81 | Muscle fiber inclusion bodies (HP:0100299) | 2.06735794 |
82 | Nemaline bodies (HP:0003798) | 2.06210019 |
83 | Volvulus (HP:0002580) | 2.05485956 |
84 | Hypoventilation (HP:0002791) | 2.02715077 |
85 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.02692379 |
86 | Abnormality of glycine metabolism (HP:0010895) | 2.02692379 |
87 | Mesangial abnormality (HP:0001966) | 2.01886085 |
88 | 3-Methylglutaconic aciduria (HP:0003535) | 2.01439831 |
89 | Optic nerve coloboma (HP:0000588) | 2.01082033 |
90 | Poor suck (HP:0002033) | 1.99173686 |
91 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 1.98633117 |
92 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 1.97827217 |
93 | Abnormality of alanine metabolism (HP:0010916) | 1.97318764 |
94 | Hyperalaninemia (HP:0003348) | 1.97318764 |
95 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.97318764 |
96 | Abnormality of the renal cortex (HP:0011035) | 1.95933891 |
97 | Respiratory failure (HP:0002878) | 1.94873241 |
98 | Anencephaly (HP:0002323) | 1.94344116 |
99 | Enlarged epiphyses (HP:0010580) | 1.93256565 |
100 | Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161) | 1.92759748 |
101 | Abnormality of the middle phalanx of the 5th finger (HP:0004219) | 1.90926445 |
102 | Neoplasm of head and neck (HP:0012288) | 1.90456604 |
103 | Esophageal neoplasm (HP:0100751) | 1.90456604 |
104 | Biconcave vertebral bodies (HP:0004586) | 1.90297071 |
105 | Hyperglycinuria (HP:0003108) | 1.88948829 |
106 | Postaxial foot polydactyly (HP:0001830) | 1.88487686 |
107 | Abnormality of chromosome stability (HP:0003220) | 1.87940412 |
108 | Generalized aminoaciduria (HP:0002909) | 1.87833027 |
109 | Pancreatic cysts (HP:0001737) | 1.87612581 |
110 | Postaxial hand polydactyly (HP:0001162) | 1.86124335 |
111 | Chronic hepatic failure (HP:0100626) | 1.85279481 |
112 | Thrombocytosis (HP:0001894) | 1.83879691 |
113 | Sloping forehead (HP:0000340) | 1.81704683 |
114 | Optic nerve hypoplasia (HP:0000609) | 1.81385645 |
115 | Preaxial hand polydactyly (HP:0001177) | 1.80126833 |
116 | Gonadal dysgenesis (HP:0000133) | 1.79236482 |
117 | Cystic liver disease (HP:0006706) | 1.78993704 |
118 | Abnormality of serum amino acid levels (HP:0003112) | 1.78743563 |
119 | Depressed nasal ridge (HP:0000457) | 1.78103774 |
120 | Failure to thrive in infancy (HP:0001531) | 1.77907882 |
121 | Genital tract atresia (HP:0001827) | 1.76928918 |
122 | Abnormal lung lobation (HP:0002101) | 1.76918738 |
123 | Hypoplastic heart (HP:0001961) | 1.75925119 |
124 | Methylmalonic aciduria (HP:0012120) | 1.75873194 |
125 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.74513455 |
126 | Abnormality of the 4th metacarpal (HP:0010012) | 1.73619910 |
127 | Vaginal atresia (HP:0000148) | 1.73093152 |
128 | Anophthalmia (HP:0000528) | 1.71425302 |
129 | Chorioretinal coloboma (HP:0000567) | 1.71399603 |
130 | Heterochromia iridis (HP:0001100) | 1.71097145 |
131 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.71026960 |
132 | Optic disc pallor (HP:0000543) | 1.70753787 |
133 | Broad foot (HP:0001769) | 1.69789875 |
134 | Aplasia/Hypoplasia of the 5th finger (HP:0006262) | 1.69660881 |
135 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.69389826 |
136 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.69389826 |
137 | Abnormal protein glycosylation (HP:0012346) | 1.69389826 |
138 | Abnormal glycosylation (HP:0012345) | 1.69389826 |
139 | Short 5th finger (HP:0009237) | 1.69294489 |
140 | Duodenal stenosis (HP:0100867) | 1.69214651 |
141 | Small intestinal stenosis (HP:0012848) | 1.69214651 |
142 | Narrow forehead (HP:0000341) | 1.68842723 |
143 | Poor coordination (HP:0002370) | 1.68576352 |
144 | Abnormality of the duodenum (HP:0002246) | 1.67860734 |
145 | Abnormality of the phalanges of the 5th finger (HP:0004213) | 1.67624785 |
146 | Hyperphosphaturia (HP:0003109) | 1.67388081 |
147 | Poor head control (HP:0002421) | 1.66925963 |
148 | Sclerocornea (HP:0000647) | 1.66867726 |
149 | Pancreatic fibrosis (HP:0100732) | 1.66363471 |
150 | Muscle hypertrophy of the lower extremities (HP:0008968) | 1.65748697 |
151 | Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376) | 1.65421702 |
152 | Hypoplasia of the pons (HP:0012110) | 1.65290859 |
153 | Amniotic constriction ring (HP:0009775) | 1.65173166 |
154 | Abnormality of placental membranes (HP:0011409) | 1.65173166 |
155 | Widely patent fontanelles and sutures (HP:0004492) | 1.64832539 |
156 | Degeneration of anterior horn cells (HP:0002398) | 1.64451717 |
157 | Abnormality of the anterior horn cell (HP:0006802) | 1.64451717 |
158 | Cerebral palsy (HP:0100021) | 1.64283397 |
Rank | Gene Set | Z-score |
---|---|---|
1 | STK16 | 3.93105738 |
2 | NEK1 | 3.13950321 |
3 | TRIM28 | 3.00861561 |
4 | BMPR1B | 2.93655621 |
5 | MARK1 | 2.82608764 |
6 | TGFBR1 | 2.77001648 |
7 | SIK3 | 2.56262378 |
8 | PASK | 2.49595067 |
9 | ARAF | 2.49243507 |
10 | VRK1 | 2.47563571 |
11 | DYRK2 | 2.46897387 |
12 | BCR | 2.46348446 |
13 | EPHB2 | 2.29615325 |
14 | ERBB3 | 2.25522228 |
15 | ZAK | 2.23761399 |
16 | PIM2 | 2.22428666 |
17 | MAPK13 | 2.22156491 |
18 | OBSCN | 2.16521931 |
19 | PLK4 | 2.14525378 |
20 | MKNK1 | 1.93492585 |
21 | BCKDK | 1.92300326 |
22 | MAP3K12 | 1.91814037 |
23 | TTK | 1.89289718 |
24 | KSR1 | 1.88678395 |
25 | MAP4K2 | 1.82132256 |
26 | CDK8 | 1.80645036 |
27 | BRAF | 1.80535199 |
28 | LIMK1 | 1.78548048 |
29 | NME2 | 1.77405486 |
30 | WEE1 | 1.77290912 |
31 | WNK3 | 1.71787542 |
32 | LMTK2 | 1.70102204 |
33 | GRK1 | 1.63639940 |
34 | TNIK | 1.56133828 |
35 | PBK | 1.55088119 |
36 | MAP3K4 | 1.54353792 |
37 | SRPK1 | 1.46103443 |
38 | EIF2AK3 | 1.42907999 |
39 | EPHA4 | 1.42266766 |
40 | UHMK1 | 1.41822741 |
41 | DYRK3 | 1.36031373 |
42 | PINK1 | 1.35842643 |
43 | VRK2 | 1.33787138 |
44 | MST4 | 1.29177440 |
45 | CASK | 1.27509137 |
46 | NUAK1 | 1.22589163 |
47 | PLK1 | 1.21016219 |
48 | PNCK | 1.20587946 |
49 | CSNK1G3 | 1.18756205 |
50 | TESK1 | 1.18381032 |
51 | PLK2 | 1.17774046 |
52 | YES1 | 1.17185241 |
53 | MINK1 | 1.16899731 |
54 | MUSK | 1.16886757 |
55 | EIF2AK2 | 1.14461797 |
56 | MAP2K6 | 1.14117719 |
57 | MATK | 1.11068193 |
58 | PDK2 | 1.10882687 |
59 | FRK | 1.08726094 |
60 | TAOK2 | 1.06487249 |
61 | ACVR1B | 1.06399003 |
62 | ADRBK1 | 1.03880555 |
63 | BRSK2 | 1.02910661 |
64 | NEK2 | 1.01471733 |
65 | MYLK | 1.00243568 |
66 | CDC7 | 0.99665753 |
67 | ADRBK2 | 0.96663903 |
68 | CCNB1 | 0.96076740 |
69 | MAP2K7 | 0.94360795 |
70 | KIT | 0.94072643 |
71 | STK39 | 0.88411453 |
72 | RPS6KA4 | 0.87725923 |
73 | RPS6KB2 | 0.86418323 |
74 | ATR | 0.82001319 |
75 | NTRK2 | 0.81588673 |
76 | TESK2 | 0.80652032 |
77 | INSRR | 0.77083015 |
78 | NME1 | 0.76516749 |
79 | PLK3 | 0.74938013 |
80 | ILK | 0.74720312 |
81 | OXSR1 | 0.74175638 |
82 | WNK4 | 0.74107547 |
83 | CDK7 | 0.73828846 |
84 | RAF1 | 0.73558096 |
85 | FLT3 | 0.73549319 |
86 | TIE1 | 0.73506683 |
87 | BUB1 | 0.73152367 |
88 | PAK4 | 0.69401268 |
89 | EIF2AK1 | 0.68956144 |
90 | CSNK1G2 | 0.68144623 |
91 | ERBB2 | 0.68092831 |
92 | TSSK6 | 0.67354759 |
93 | PKN1 | 0.66989097 |
94 | CDK19 | 0.66860753 |
95 | STK24 | 0.66662217 |
96 | PHKG2 | 0.66221063 |
97 | PHKG1 | 0.66221063 |
98 | STK38L | 0.65811210 |
99 | AURKA | 0.64484854 |
100 | CSNK1G1 | 0.64032749 |
101 | TGFBR2 | 0.63867017 |
102 | CSNK2A1 | 0.63672527 |
103 | LRRK2 | 0.63538693 |
104 | RPS6KA5 | 0.63478507 |
105 | CDK18 | 0.63065963 |
106 | PAK3 | 0.57675104 |
107 | PRKCG | 0.57488414 |
108 | PRKCE | 0.56776386 |
109 | STK3 | 0.55904413 |
110 | MAPK4 | 0.55259575 |
111 | ATM | 0.54887790 |
112 | CDK14 | 0.54125313 |
113 | CHEK2 | 0.53260480 |
114 | MAPKAPK5 | 0.52267833 |
115 | BRSK1 | 0.51809031 |
116 | PRKG2 | 0.49561724 |
117 | KDR | 0.48865441 |
118 | RPS6KB1 | 0.48295748 |
119 | CDK15 | 0.47276008 |
120 | CAMK2A | 0.46225086 |
121 | CDK11A | 0.45478592 |
122 | SCYL2 | 0.45180631 |
123 | RPS6KA2 | 0.42134538 |
124 | DAPK1 | 0.41362535 |
125 | CSNK1E | 0.40932346 |
126 | MAP2K1 | 0.39639376 |
127 | ABL2 | 0.39530423 |
128 | IRAK2 | 0.39189861 |
129 | RPS6KL1 | 0.38984526 |
130 | RPS6KC1 | 0.38984526 |
131 | PTK6 | 0.38436973 |
132 | CSNK2A2 | 0.38046132 |
133 | DYRK1A | 0.37868418 |
134 | CSNK1A1L | 0.36267765 |
135 | FGFR1 | 0.36027956 |
136 | CSNK1A1 | 0.34878232 |
137 | NLK | 0.34800954 |
138 | PAK2 | 0.34463850 |
139 | PRKACB | 0.31998003 |
140 | ERBB4 | 0.31205033 |
141 | AURKB | 0.30858371 |
142 | ERN1 | 0.29909412 |
143 | GRK7 | 0.29872032 |
144 | MKNK2 | 0.29837381 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Ribosome_Homo sapiens_hsa03010 | 5.08042444 |
2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.57620333 |
3 | Parkinsons disease_Homo sapiens_hsa05012 | 3.53528346 |
4 | Proteasome_Homo sapiens_hsa03050 | 3.26291937 |
5 | DNA replication_Homo sapiens_hsa03030 | 3.13296801 |
6 | Mismatch repair_Homo sapiens_hsa03430 | 2.61692606 |
7 | Protein export_Homo sapiens_hsa03060 | 2.59256803 |
8 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.51508397 |
9 | Huntingtons disease_Homo sapiens_hsa05016 | 2.36306163 |
10 | Alzheimers disease_Homo sapiens_hsa05010 | 2.31449051 |
11 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.14569336 |
12 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 2.08027750 |
13 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.03094962 |
14 | RNA polymerase_Homo sapiens_hsa03020 | 1.95458674 |
15 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.91796911 |
16 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.85632942 |
17 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.83851355 |
18 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.81783290 |
19 | Spliceosome_Homo sapiens_hsa03040 | 1.79735228 |
20 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.74699846 |
21 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.72886609 |
22 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.68747534 |
23 | Base excision repair_Homo sapiens_hsa03410 | 1.67399869 |
24 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.60840540 |
25 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.47711566 |
26 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.41663927 |
27 | Homologous recombination_Homo sapiens_hsa03440 | 1.39413940 |
28 | Phototransduction_Homo sapiens_hsa04744 | 1.37214299 |
29 | Fatty acid degradation_Homo sapiens_hsa00071 | 1.35429275 |
30 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.33974945 |
31 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.30395318 |
32 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 1.23276323 |
33 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.21365217 |
34 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.18417270 |
35 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.16932648 |
36 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.13776844 |
37 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.13131675 |
38 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.12753879 |
39 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.12356813 |
40 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.11488830 |
41 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.10172795 |
42 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.09685758 |
43 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.06336689 |
44 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.05105297 |
45 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.04838493 |
46 | Galactose metabolism_Homo sapiens_hsa00052 | 1.04219018 |
47 | Purine metabolism_Homo sapiens_hsa00230 | 1.02843542 |
48 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.01927030 |
49 | Carbon metabolism_Homo sapiens_hsa01200 | 1.00336224 |
50 | Sulfur relay system_Homo sapiens_hsa04122 | 1.00278555 |
51 | RNA degradation_Homo sapiens_hsa03018 | 0.98321468 |
52 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.96530659 |
53 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.96292315 |
54 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.96044470 |
55 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.94412966 |
56 | Peroxisome_Homo sapiens_hsa04146 | 0.92205438 |
57 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.92073282 |
58 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.88073353 |
59 | Basal transcription factors_Homo sapiens_hsa03022 | 0.87054792 |
60 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.85878494 |
61 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.84070477 |
62 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.82889263 |
63 | Metabolic pathways_Homo sapiens_hsa01100 | 0.81889037 |
64 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.81310755 |
65 | RNA transport_Homo sapiens_hsa03013 | 0.80897629 |
66 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.79949387 |
67 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.77347406 |
68 | Nicotine addiction_Homo sapiens_hsa05033 | 0.76204822 |
69 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.75830486 |
70 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.74737442 |
71 | Cell cycle_Homo sapiens_hsa04110 | 0.73203892 |
72 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.71437269 |
73 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.71069102 |
74 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.69414675 |
75 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.68431225 |
76 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.63661270 |
77 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.62508206 |
78 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.60704164 |
79 | Retinol metabolism_Homo sapiens_hsa00830 | 0.60609640 |
80 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.59964177 |
81 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.58994307 |
82 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.56917888 |
83 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.55554169 |
84 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.54550278 |
85 | Taste transduction_Homo sapiens_hsa04742 | 0.53564905 |
86 | Olfactory transduction_Homo sapiens_hsa04740 | 0.50416169 |
87 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.49724520 |
88 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.49707719 |
89 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.48968460 |
90 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.48533532 |
91 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.48046558 |
92 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.47721647 |
93 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.47379705 |
94 | Circadian rhythm_Homo sapiens_hsa04710 | 0.46988598 |
95 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.45538920 |
96 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.45334763 |
97 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.44948128 |
98 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.44898937 |
99 | Alcoholism_Homo sapiens_hsa05034 | 0.43067847 |
100 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.42935585 |
101 | Legionellosis_Homo sapiens_hsa05134 | 0.42775471 |
102 | Thyroid cancer_Homo sapiens_hsa05216 | 0.42652305 |
103 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.41180192 |
104 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.39912736 |
105 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.39621458 |
106 | GABAergic synapse_Homo sapiens_hsa04727 | 0.37823870 |
107 | Histidine metabolism_Homo sapiens_hsa00340 | 0.35957389 |
108 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.35937957 |
109 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.35797695 |
110 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.35571691 |
111 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.34274502 |
112 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.33136700 |
113 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.31593692 |
114 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.31049108 |
115 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.30795229 |
116 | Phagosome_Homo sapiens_hsa04145 | 0.29907705 |
117 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.28556908 |
118 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.28138414 |
119 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.26879880 |
120 | Colorectal cancer_Homo sapiens_hsa05210 | 0.24147771 |
121 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.22937049 |
122 | Bladder cancer_Homo sapiens_hsa05219 | 0.22544894 |
123 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.21812971 |
124 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.21196462 |
125 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.21010438 |
126 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.19100037 |
127 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.18062543 |
128 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.15913623 |
129 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.15641564 |