PRKRA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.64635645
2viral transcription (GO:0019083)6.23838330
3translational termination (GO:0006415)6.05236775
4ribosomal small subunit biogenesis (GO:0042274)5.99148238
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.56537366
6cotranslational protein targeting to membrane (GO:0006613)5.51300438
7ATP synthesis coupled proton transport (GO:0015986)5.44702499
8energy coupled proton transport, down electrochemical gradient (GO:0015985)5.44702499
9protein targeting to ER (GO:0045047)5.42525289
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.35446014
11translational elongation (GO:0006414)5.18962719
12protein localization to endoplasmic reticulum (GO:0070972)5.18054845
13establishment of protein localization to endoplasmic reticulum (GO:0072599)5.10945200
14pyrimidine nucleobase catabolic process (GO:0006208)5.06018578
15viral life cycle (GO:0019058)4.82191576
16cellular protein complex disassembly (GO:0043624)4.74894164
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.64544564
18maturation of SSU-rRNA (GO:0030490)4.61765527
19protein complex disassembly (GO:0043241)4.33655615
20cullin deneddylation (GO:0010388)4.23175260
21oxidative phosphorylation (GO:0006119)4.22447856
22macromolecular complex disassembly (GO:0032984)4.17613979
23respiratory chain complex IV assembly (GO:0008535)4.02508679
24translational initiation (GO:0006413)4.00191146
25deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.96837970
26DNA double-strand break processing (GO:0000729)3.95890184
27mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.93291700
28protein deneddylation (GO:0000338)3.87791565
29proteasome assembly (GO:0043248)3.86202370
30urogenital system development (GO:0001655)3.84529803
31respiratory electron transport chain (GO:0022904)3.80397377
32DNA deamination (GO:0045006)3.78096004
33fat-soluble vitamin biosynthetic process (GO:0042362)3.76854093
34chromatin remodeling at centromere (GO:0031055)3.75301318
35electron transport chain (GO:0022900)3.72339762
36establishment of protein localization to mitochondrial membrane (GO:0090151)3.65361213
37protein complex biogenesis (GO:0070271)3.61986864
38tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.61700820
39RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.61700820
40CENP-A containing nucleosome assembly (GO:0034080)3.61076842
41nucleobase catabolic process (GO:0046113)3.53215859
42translation (GO:0006412)3.50567883
43platelet dense granule organization (GO:0060155)3.48917367
442-deoxyribonucleotide biosynthetic process (GO:0009265)3.44451479
45deoxyribose phosphate biosynthetic process (GO:0046385)3.44451479
46protein targeting to membrane (GO:0006612)3.43142652
47NADH dehydrogenase complex assembly (GO:0010257)3.42294364
48mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.42294364
49mitochondrial respiratory chain complex I assembly (GO:0032981)3.42294364
50mitochondrial respiratory chain complex assembly (GO:0033108)3.39479404
51nuclear-transcribed mRNA catabolic process (GO:0000956)3.36932481
52establishment of integrated proviral latency (GO:0075713)3.32128120
53de novo posttranslational protein folding (GO:0051084)3.25598022
54DNA damage response, detection of DNA damage (GO:0042769)3.22621488
55deoxyribonucleotide biosynthetic process (GO:0009263)3.21565763
56histone exchange (GO:0043486)3.20971886
57chaperone-mediated protein transport (GO:0072321)3.18631227
58cytochrome complex assembly (GO:0017004)3.18172148
59histone H2A acetylation (GO:0043968)3.16655226
60telomere maintenance via semi-conservative replication (GO:0032201)3.13518886
61ribosomal large subunit biogenesis (GO:0042273)3.13306937
62pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.12785447
63mRNA catabolic process (GO:0006402)3.11863482
64DNA strand elongation involved in DNA replication (GO:0006271)3.11432110
65protein neddylation (GO:0045116)3.09165047
66replication fork processing (GO:0031297)3.09087489
67negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.06768505
68regulation of mitotic spindle checkpoint (GO:1903504)3.02496077
69regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.02496077
70de novo protein folding (GO:0006458)3.01922312
71DNA strand elongation (GO:0022616)2.99708739
72regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.98049045
73aerobic respiration (GO:0009060)2.97740387
74response to pheromone (GO:0019236)2.97197559
75spinal cord association neuron differentiation (GO:0021527)2.95523368
76ubiquinone metabolic process (GO:0006743)2.94495771
77kinetochore assembly (GO:0051382)2.93902381
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.92440632
79DNA catabolic process, exonucleolytic (GO:0000738)2.91731723
80kinetochore organization (GO:0051383)2.90961374
81protein-cofactor linkage (GO:0018065)2.89162306
82negative regulation of RNA splicing (GO:0033119)2.88822089
83cranial nerve morphogenesis (GO:0021602)2.86320544
84L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.85787897
85facial nerve structural organization (GO:0021612)2.85732829
86anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.84692749
87negative regulation of microtubule polymerization (GO:0031115)2.83041819
88RNA catabolic process (GO:0006401)2.81620840
89exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.79316294
90protein K11-linked ubiquitination (GO:0070979)2.78381541
91iron-sulfur cluster assembly (GO:0016226)2.78213009
92metallo-sulfur cluster assembly (GO:0031163)2.78213009
93intraciliary transport (GO:0042073)2.77602543
94telomere maintenance via recombination (GO:0000722)2.77237593
95DNA ligation (GO:0006266)2.76165531
96synapsis (GO:0007129)2.76141325
97ubiquinone biosynthetic process (GO:0006744)2.76014711
98pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.75478578
99regulation of cellular amino acid metabolic process (GO:0006521)2.74519421
100G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.73990524
101negative regulation of ligase activity (GO:0051352)2.73852725
102negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.73852725
103DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.72781319
104positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.71250729
105resolution of meiotic recombination intermediates (GO:0000712)2.70240189
106endosome to pigment granule transport (GO:0043485)2.70012973
107endosome to melanosome transport (GO:0035646)2.70012973
108peptidyl-arginine omega-N-methylation (GO:0035247)2.70005925
109nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.69465438
110pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.67714215
111histone mRNA metabolic process (GO:0008334)2.67549514
112somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.67183060
113isotype switching (GO:0045190)2.67183060
114somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.67183060
115purine nucleoside triphosphate biosynthetic process (GO:0009145)2.67066317
116signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.66983140
117intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.66983140
118retinal ganglion cell axon guidance (GO:0031290)2.66124484
119pyrimidine nucleobase metabolic process (GO:0006206)2.66077376
120positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.65714465
121ATP biosynthetic process (GO:0006754)2.65149781
122regulation of mitochondrial translation (GO:0070129)2.64994806
123protein K6-linked ubiquitination (GO:0085020)2.63455633
124purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.62062976
125protein polyglutamylation (GO:0018095)2.61573509
126pseudouridine synthesis (GO:0001522)2.61212216
127regulation of double-strand break repair via homologous recombination (GO:0010569)2.61092693
128positive regulation of receptor biosynthetic process (GO:0010870)2.60662805
129positive regulation of mitochondrial fission (GO:0090141)2.60584919
130signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.58417885
131signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.58417885
132signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.58417885
133antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.58381305
134pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.58004090
135DNA replication-independent nucleosome organization (GO:0034724)2.57956567
136DNA replication-independent nucleosome assembly (GO:0006336)2.57956567
137mitotic metaphase plate congression (GO:0007080)2.57695066
138positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.57044794
139response to misfolded protein (GO:0051788)2.56763042
140termination of RNA polymerase III transcription (GO:0006386)2.56446867
141transcription elongation from RNA polymerase III promoter (GO:0006385)2.56446867
142aldehyde catabolic process (GO:0046185)2.56387349
143spindle checkpoint (GO:0031577)2.54959959
144centriole replication (GO:0007099)2.54370741
145RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.54093370
146negative regulation of DNA recombination (GO:0045910)2.53194474
147mitotic spindle checkpoint (GO:0071174)2.51130072
148somatic hypermutation of immunoglobulin genes (GO:0016446)2.50213102
149somatic diversification of immune receptors via somatic mutation (GO:0002566)2.50213102
150protein targeting to mitochondrion (GO:0006626)2.49194684
151negative regulation of mitotic sister chromatid separation (GO:2000816)2.47948478
152negative regulation of sister chromatid segregation (GO:0033046)2.47948478
153negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.47948478
154negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.47948478
155negative regulation of mitotic sister chromatid segregation (GO:0033048)2.47948478
156inner mitochondrial membrane organization (GO:0007007)2.45236807
157nucleotide-excision repair, DNA gap filling (GO:0006297)2.45126562
158metaphase plate congression (GO:0051310)2.44524926
159organelle disassembly (GO:1903008)2.44447539
160branched-chain amino acid catabolic process (GO:0009083)2.44033039
161protein localization to mitochondrion (GO:0070585)2.43552971
162regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.43146656
163maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.42809400
164positive regulation of ligase activity (GO:0051351)2.41388485
165negative regulation of DNA-dependent DNA replication (GO:2000104)2.40738155
166recombinational repair (GO:0000725)2.40522215
167negative regulation of chromosome segregation (GO:0051985)2.40187979
168base-excision repair, AP site formation (GO:0006285)2.40181336
169peptidyl-histidine modification (GO:0018202)2.39251177

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.44321138
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.34167052
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.09623104
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.03515017
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.89609056
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.72635926
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.57509051
8E2F7_22180533_ChIP-Seq_HELA_Human3.54453038
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.28280132
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.09545638
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.81068305
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.80753332
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.77544885
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.73540465
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.72797150
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.66982663
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.63840956
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.58258783
19XRN2_22483619_ChIP-Seq_HELA_Human2.53606569
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.32203962
21E2F1_18555785_ChIP-Seq_MESCs_Mouse2.30212254
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.30166151
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.28887992
24DCP1A_22483619_ChIP-Seq_HELA_Human2.26305787
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.25767993
26ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.18236638
27POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16863502
28ETS1_20019798_ChIP-Seq_JURKAT_Human2.16785950
29MYC_19079543_ChIP-ChIP_MESCs_Mouse2.11921229
30TTF2_22483619_ChIP-Seq_HELA_Human2.08992391
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.05621893
32MYC_19030024_ChIP-ChIP_MESCs_Mouse2.03626066
33VDR_22108803_ChIP-Seq_LS180_Human2.03219650
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.01151989
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.99947055
36ELK1_19687146_ChIP-ChIP_HELA_Human1.99944581
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94165995
38CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.93654206
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.93147351
40GBX2_23144817_ChIP-Seq_PC3_Human1.85461934
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.79925395
42VDR_23849224_ChIP-Seq_CD4+_Human1.78592646
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.78089551
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.77616555
45KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.74629212
46TAF15_26573619_Chip-Seq_HEK293_Human1.73767071
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.73716700
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.73174841
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70230035
50FOXP3_21729870_ChIP-Seq_TREG_Human1.69060927
51GABP_19822575_ChIP-Seq_HepG2_Human1.66974096
52P300_19829295_ChIP-Seq_ESCs_Human1.65518201
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.64800991
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64704395
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63654180
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63508721
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.61517341
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.59171535
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.58573879
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53063025
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51890667
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49025396
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47507218
64CTCF_18555785_ChIP-Seq_MESCs_Mouse1.47276173
65CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.45259963
66IRF1_19129219_ChIP-ChIP_H3396_Human1.44660211
67IGF1R_20145208_ChIP-Seq_DFB_Human1.42323666
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40816057
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.39454438
70FOXM1_23109430_ChIP-Seq_U2OS_Human1.37072991
71KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36335732
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35830286
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35389922
74ELK1_22589737_ChIP-Seq_MCF10A_Human1.34504538
75MYC_18940864_ChIP-ChIP_HL60_Human1.34367800
76SOX2_18555785_ChIP-Seq_MESCs_Mouse1.34289664
77E2F4_17652178_ChIP-ChIP_JURKAT_Human1.33308882
78CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.31952176
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28250888
80DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27222602
81MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.26796936
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26000397
83* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25452202
84FUS_26573619_Chip-Seq_HEK293_Human1.25292459
85FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.24271981
86EZH2_27304074_Chip-Seq_ESCs_Mouse1.23553853
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22671457
88HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21923837
89EZH2_27294783_Chip-Seq_NPCs_Mouse1.21231310
90WT1_19549856_ChIP-ChIP_CCG9911_Human1.19667838
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18908499
92ER_23166858_ChIP-Seq_MCF-7_Human1.17959056
93MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.17947760
94TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.16515714
95KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15832750
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14732918
97EWS_26573619_Chip-Seq_HEK293_Human1.14460862
98SOX17_20123909_ChIP-Seq_XEN_Mouse1.13848019
99YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12640345
100CBP_20019798_ChIP-Seq_JUKART_Human1.12048466
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12048466
102SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11969572
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10987844
104PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.10787740
105NANOG_16153702_ChIP-ChIP_HESCs_Human1.10162245
106TP53_22573176_ChIP-Seq_HFKS_Human1.09911793
107RNF2_27304074_Chip-Seq_NSC_Mouse1.09319613
108FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.08839887
109RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08673888
110SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08420332
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06819219
112NFE2_27457419_Chip-Seq_LIVER_Mouse1.06280368
113TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04782674
114POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03591596
115TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01998077
116ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01785394
117UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01493044
118CIITA_25753668_ChIP-Seq_RAJI_Human1.01400241
119SOX2_16153702_ChIP-ChIP_HESCs_Human1.00879749
120NANOG_19829295_ChIP-Seq_ESCs_Human1.00166501
121SOX2_19829295_ChIP-Seq_ESCs_Human1.00166501
122CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.97891209
123SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96750381
124SMAD3_21741376_ChIP-Seq_EPCs_Human0.95798149
125CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94893186
126CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94684548
127EED_16625203_ChIP-ChIP_MESCs_Mouse0.94325091
128SMAD4_21799915_ChIP-Seq_A2780_Human0.94021878
129OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94002184
130AR_21909140_ChIP-Seq_LNCAP_Human0.93395864
131CRX_20693478_ChIP-Seq_RETINA_Mouse0.91686132
132ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91113915
133SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90547240
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89731991
135EZH2_22144423_ChIP-Seq_EOC_Human0.89245938
136E2F1_21310950_ChIP-Seq_MCF-7_Human0.89117925
137OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.88357579
138GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87972570
139BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87777511
140GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82301765
141MYCN_18555785_ChIP-Seq_MESCs_Mouse0.81325559
142SALL1_21062744_ChIP-ChIP_HESCs_Human0.80957206
143ZNF274_21170338_ChIP-Seq_K562_Hela0.79594475
144PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.77267198
145CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.76819970

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.27011060
2MP0003122_maternal_imprinting4.36623502
3MP0002938_white_spotting3.89692419
4MP0005083_abnormal_biliary_tract3.33034478
5MP0010030_abnormal_orbit_morphology3.10454945
6MP0003880_abnormal_central_pattern2.91402209
7MP0006054_spinal_hemorrhage2.79623842
8MP0002102_abnormal_ear_morphology2.46908822
9MP0000566_synostosis2.45345794
10MP0001529_abnormal_vocalization2.41572059
11MP0003942_abnormal_urinary_system2.36688667
12MP0009697_abnormal_copulation2.33900636
13MP0003121_genomic_imprinting2.32769016
14MP0004145_abnormal_muscle_electrophysio2.28307540
15MP0006276_abnormal_autonomic_nervous2.24494791
16MP0008877_abnormal_DNA_methylation2.18290103
17MP0000372_irregular_coat_pigmentation2.13465026
18MP0009053_abnormal_anal_canal2.11334984
19MP0003011_delayed_dark_adaptation2.08307718
20MP0010094_abnormal_chromosome_stability2.06552142
21MP0003123_paternal_imprinting2.06143547
22MP0008789_abnormal_olfactory_epithelium2.00951933
23MP0002837_dystrophic_cardiac_calcinosis1.99177488
24MP0005174_abnormal_tail_pigmentation1.98648141
25MP0000537_abnormal_urethra_morphology1.97095732
26MP0003315_abnormal_perineum_morphology1.92371456
27MP0002751_abnormal_autonomic_nervous1.74704413
28MP0000749_muscle_degeneration1.71899904
29MP0009046_muscle_twitch1.71619817
30MP0001293_anophthalmia1.70685951
31MP0002638_abnormal_pupillary_reflex1.67428601
32MP0008007_abnormal_cellular_replicative1.65485270
33MP0003646_muscle_fatigue1.65104662
34* MP0000049_abnormal_middle_ear1.64647696
35MP0003718_maternal_effect1.64642852
36MP0005379_endocrine/exocrine_gland_phen1.63988048
37MP0005423_abnormal_somatic_nervous1.63741345
38MP0003693_abnormal_embryo_hatching1.60986732
39MP0002282_abnormal_trachea_morphology1.54213506
40MP0008995_early_reproductive_senescence1.54089701
41MP0004215_abnormal_myocardial_fiber1.52909405
42MP0003385_abnormal_body_wall1.51997856
43MP0009384_cardiac_valve_regurgitation1.50220069
44MP0006072_abnormal_retinal_apoptosis1.49970559
45MP0005645_abnormal_hypothalamus_physiol1.48958306
46MP0005551_abnormal_eye_electrophysiolog1.46726602
47MP0005084_abnormal_gallbladder_morpholo1.45277798
48MP0001188_hyperpigmentation1.43548165
49MP0003567_abnormal_fetal_cardiomyocyte1.39521726
50MP0001485_abnormal_pinna_reflex1.36804874
51MP0000631_abnormal_neuroendocrine_gland1.36344873
52MP0004142_abnormal_muscle_tone1.32907233
53MP0005248_abnormal_Harderian_gland1.32907122
54MP0009250_abnormal_appendicular_skeleto1.32581994
55MP0003787_abnormal_imprinting1.31792205
56MP0001905_abnormal_dopamine_level1.30919865
57MP0000778_abnormal_nervous_system1.28665139
58MP0002163_abnormal_gland_morphology1.28549827
59MP0003937_abnormal_limbs/digits/tail_de1.27150275
60MP0002139_abnormal_hepatobiliary_system1.27149355
61MP0005187_abnormal_penis_morphology1.27089470
62MP0002132_abnormal_respiratory_system1.26788410
63MP0005408_hypopigmentation1.23868346
64MP0003136_yellow_coat_color1.23456377
65MP0002822_catalepsy1.22155512
66MP0005253_abnormal_eye_physiology1.21612888
67MP0002160_abnormal_reproductive_system1.21534265
68MP0001986_abnormal_taste_sensitivity1.20698540
69MP0005646_abnormal_pituitary_gland1.18182709
70MP0004133_heterotaxia1.16790519
71MP0002272_abnormal_nervous_system1.14822607
72MP0000015_abnormal_ear_pigmentation1.13911410
73MP0002234_abnormal_pharynx_morphology1.13679306
74MP0002210_abnormal_sex_determination1.12984545
75MP0001929_abnormal_gametogenesis1.12712032
76MP0001879_abnormal_lymphatic_vessel1.12460332
77MP0006036_abnormal_mitochondrial_physio1.11734896
78MP0005499_abnormal_olfactory_system1.09867037
79MP0005394_taste/olfaction_phenotype1.09867037
80MP0002095_abnormal_skin_pigmentation1.09786190
81MP0002932_abnormal_joint_morphology1.09197022
82MP0001324_abnormal_eye_pigmentation1.09106494
83MP0006292_abnormal_olfactory_placode1.07502176
84MP0000534_abnormal_ureter_morphology1.07283031
85MP0003786_premature_aging1.05901799
86MP0003137_abnormal_impulse_conducting1.05295458
87MP0000569_abnormal_digit_pigmentation1.03599370
88MP0003111_abnormal_nucleus_morphology1.03219242
89MP0001486_abnormal_startle_reflex1.02621135
90MP0002736_abnormal_nociception_after1.00591717
91MP0001984_abnormal_olfaction0.98913893
92MP0000538_abnormal_urinary_bladder0.95580775
93MP0000653_abnormal_sex_gland0.95336479
94MP0005365_abnormal_bile_salt0.94571542
95MP0002249_abnormal_larynx_morphology0.92061187
96MP0004270_analgesia0.90523496
97MP0009745_abnormal_behavioral_response0.89980078
98MP0000647_abnormal_sebaceous_gland0.88859259
99MP0001145_abnormal_male_reproductive0.88247965
100MP0000462_abnormal_digestive_system0.87549534
101MP0003943_abnormal_hepatobiliary_system0.86525449
102MP0003698_abnormal_male_reproductive0.86454984
103MP0002752_abnormal_somatic_nervous0.86426190
104MP0002067_abnormal_sensory_capabilities0.86334937
105MP0005220_abnormal_exocrine_pancreas0.84156459
106MP0004233_abnormal_muscle_weight0.84078135
107MP0001299_abnormal_eye_distance/0.83615189
108MP0002184_abnormal_innervation0.83288949
109MP0002653_abnormal_ependyma_morphology0.83152695
110MP0004957_abnormal_blastocyst_morpholog0.82629459
111MP0006035_abnormal_mitochondrial_morpho0.82215102
112MP0003221_abnormal_cardiomyocyte_apopto0.81874354
113MP0000026_abnormal_inner_ear0.81816415
114MP0001286_abnormal_eye_development0.80689112
115MP0004924_abnormal_behavior0.79162113
116MP0005386_behavior/neurological_phenoty0.79162113
117MP0004808_abnormal_hematopoietic_stem0.78560871
118MP0003755_abnormal_palate_morphology0.78541215
119MP0008932_abnormal_embryonic_tissue0.78434525
120MP0005075_abnormal_melanosome_morpholog0.78272262
121MP0005197_abnormal_uvea_morphology0.75584268
122MP0002106_abnormal_muscle_physiology0.75224179
123MP0003183_abnormal_peptide_metabolism0.74491214
124MP0001764_abnormal_homeostasis0.74339129
125MP0005171_absent_coat_pigmentation0.74318611
126MP0005391_vision/eye_phenotype0.73263080
127MP0005195_abnormal_posterior_eye0.73191548
128MP0003119_abnormal_digestive_system0.72481762
129MP0005266_abnormal_metabolism0.72056693
130MP0002127_abnormal_cardiovascular_syste0.71331442
131* MP0002177_abnormal_outer_ear0.70589387
132MP0001968_abnormal_touch/_nociception0.70546358
133* MP0002233_abnormal_nose_morphology0.68729667
134MP0008058_abnormal_DNA_repair0.68535751
135MP0001727_abnormal_embryo_implantation0.68435977
136MP0004147_increased_porphyrin_level0.67788336
137MP0005377_hearing/vestibular/ear_phenot0.67457301
138MP0003878_abnormal_ear_physiology0.67457301
139MP0003959_abnormal_lean_body0.67130522
140MP0002557_abnormal_social/conspecific_i0.66229238
141MP0010386_abnormal_urinary_bladder0.64530465
142MP0003115_abnormal_respiratory_system0.63590955
143MP0003186_abnormal_redox_activity0.63394592
144MP0003077_abnormal_cell_cycle0.63131362
145MP0010368_abnormal_lymphatic_system0.61051208
146MP0000751_myopathy0.60746705
147MP0003890_abnormal_embryonic-extraembry0.58582811

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.61872208
2Mitochondrial inheritance (HP:0001427)4.35161739
3Abnormal number of erythroid precursors (HP:0012131)4.29507975
4Acute necrotizing encephalopathy (HP:0006965)4.15371768
5Increased hepatocellular lipid droplets (HP:0006565)4.06781814
6Lipid accumulation in hepatocytes (HP:0006561)3.99372228
7Increased CSF lactate (HP:0002490)3.89144135
8Abnormal mitochondria in muscle tissue (HP:0008316)3.84862017
9Hepatocellular necrosis (HP:0001404)3.83822218
10Reticulocytopenia (HP:0001896)3.75282680
11Hypothermia (HP:0002045)3.70629804
12Abnormality of the labia minora (HP:0012880)3.66266315
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.56094152
14Hepatic necrosis (HP:0002605)3.51979768
15Renal Fanconi syndrome (HP:0001994)3.50089768
16Colon cancer (HP:0003003)3.48158946
17Acute encephalopathy (HP:0006846)3.40129842
18Molar tooth sign on MRI (HP:0002419)3.38132539
19Abnormality of midbrain morphology (HP:0002418)3.38132539
20Progressive macrocephaly (HP:0004481)3.36242587
21Increased intramyocellular lipid droplets (HP:0012240)3.20675597
22Increased serum pyruvate (HP:0003542)3.18940520
23Abnormality of glycolysis (HP:0004366)3.18940520
24Hyperglycinemia (HP:0002154)3.05526647
25Increased muscle lipid content (HP:0009058)2.97958880
26Aplastic anemia (HP:0001915)2.97755524
27Pallor (HP:0000980)2.81248244
28Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.80449551
29Wide cranial sutures (HP:0010537)2.79555099
30Macrocytic anemia (HP:0001972)2.73869112
31Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.68112645
32Decreased activity of mitochondrial respiratory chain (HP:0008972)2.68112645
33Chromosomal breakage induced by crosslinking agents (HP:0003221)2.64141660
34Nephronophthisis (HP:0000090)2.63615498
35Respiratory difficulties (HP:0002880)2.63384390
36Intestinal atresia (HP:0011100)2.60253920
37Gait imbalance (HP:0002141)2.59740114
38Exercise intolerance (HP:0003546)2.53018403
39Increased serum lactate (HP:0002151)2.52351048
40Exercise-induced muscle cramps (HP:0003710)2.47447376
41Chromsome breakage (HP:0040012)2.46325024
42Abnormal biliary tract physiology (HP:0012439)2.46170239
43Bile duct proliferation (HP:0001408)2.46170239
44Exertional dyspnea (HP:0002875)2.45975167
45Hypoplastic left heart (HP:0004383)2.45804767
46Thin bony cortex (HP:0002753)2.44848692
47True hermaphroditism (HP:0010459)2.44718863
48Severe visual impairment (HP:0001141)2.44684555
49Short middle phalanx of the 5th finger (HP:0004220)2.44267879
50Lactic acidosis (HP:0003128)2.44263472
51Cerebral edema (HP:0002181)2.42085774
52Supernumerary spleens (HP:0009799)2.39395117
53Meckel diverticulum (HP:0002245)2.37513398
54Retinal dysplasia (HP:0007973)2.36310966
55Renal cortical cysts (HP:0000803)2.35931104
56Abnormality of the ileum (HP:0001549)2.35809851
57Medial flaring of the eyebrow (HP:0010747)2.35651754
58Microvesicular hepatic steatosis (HP:0001414)2.33843265
59Nephrogenic diabetes insipidus (HP:0009806)2.31705516
60Aplasia/Hypoplasia of the uvula (HP:0010293)2.31396301
61Lissencephaly (HP:0001339)2.30521104
62Congenital primary aphakia (HP:0007707)2.26924592
63Bifid tongue (HP:0010297)2.26045360
64Rimmed vacuoles (HP:0003805)2.24541589
65Pheochromocytoma (HP:0002666)2.21869926
6611 pairs of ribs (HP:0000878)2.21389251
67Neoplasm of the adrenal gland (HP:0100631)2.17385762
68Cortical dysplasia (HP:0002539)2.16084116
69Short 4th metacarpal (HP:0010044)2.12773010
70Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.12773010
71Type I transferrin isoform profile (HP:0003642)2.11794328
72Neuroendocrine neoplasm (HP:0100634)2.10599096
73Abnormality of the renal medulla (HP:0100957)2.09840663
74Polyphagia (HP:0002591)2.08931883
75Aplasia/Hypoplasia of the sacrum (HP:0008517)2.08898569
76Methylmalonic acidemia (HP:0002912)2.07862422
77Glycosuria (HP:0003076)2.07416326
78Abnormality of urine glucose concentration (HP:0011016)2.07416326
79Abnormality of renal resorption (HP:0011038)2.07057080
80Type 2 muscle fiber atrophy (HP:0003554)2.06821924
81Muscle fiber inclusion bodies (HP:0100299)2.06735794
82Nemaline bodies (HP:0003798)2.06210019
83Volvulus (HP:0002580)2.05485956
84Hypoventilation (HP:0002791)2.02715077
85Abnormality of serine family amino acid metabolism (HP:0010894)2.02692379
86Abnormality of glycine metabolism (HP:0010895)2.02692379
87Mesangial abnormality (HP:0001966)2.01886085
883-Methylglutaconic aciduria (HP:0003535)2.01439831
89Optic nerve coloboma (HP:0000588)2.01082033
90Poor suck (HP:0002033)1.99173686
91Abnormality of the heme biosynthetic pathway (HP:0010472)1.98633117
92Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.97827217
93Abnormality of alanine metabolism (HP:0010916)1.97318764
94Hyperalaninemia (HP:0003348)1.97318764
95Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.97318764
96Abnormality of the renal cortex (HP:0011035)1.95933891
97Respiratory failure (HP:0002878)1.94873241
98Anencephaly (HP:0002323)1.94344116
99Enlarged epiphyses (HP:0010580)1.93256565
100Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.92759748
101Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.90926445
102Neoplasm of head and neck (HP:0012288)1.90456604
103Esophageal neoplasm (HP:0100751)1.90456604
104Biconcave vertebral bodies (HP:0004586)1.90297071
105Hyperglycinuria (HP:0003108)1.88948829
106Postaxial foot polydactyly (HP:0001830)1.88487686
107Abnormality of chromosome stability (HP:0003220)1.87940412
108Generalized aminoaciduria (HP:0002909)1.87833027
109Pancreatic cysts (HP:0001737)1.87612581
110Postaxial hand polydactyly (HP:0001162)1.86124335
111Chronic hepatic failure (HP:0100626)1.85279481
112Thrombocytosis (HP:0001894)1.83879691
113Sloping forehead (HP:0000340)1.81704683
114Optic nerve hypoplasia (HP:0000609)1.81385645
115Preaxial hand polydactyly (HP:0001177)1.80126833
116Gonadal dysgenesis (HP:0000133)1.79236482
117Cystic liver disease (HP:0006706)1.78993704
118Abnormality of serum amino acid levels (HP:0003112)1.78743563
119Depressed nasal ridge (HP:0000457)1.78103774
120Failure to thrive in infancy (HP:0001531)1.77907882
121Genital tract atresia (HP:0001827)1.76928918
122Abnormal lung lobation (HP:0002101)1.76918738
123Hypoplastic heart (HP:0001961)1.75925119
124Methylmalonic aciduria (HP:0012120)1.75873194
125Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74513455
126Abnormality of the 4th metacarpal (HP:0010012)1.73619910
127Vaginal atresia (HP:0000148)1.73093152
128Anophthalmia (HP:0000528)1.71425302
129Chorioretinal coloboma (HP:0000567)1.71399603
130Heterochromia iridis (HP:0001100)1.71097145
131Aplasia/Hypoplasia of the tongue (HP:0010295)1.71026960
132Optic disc pallor (HP:0000543)1.70753787
133Broad foot (HP:0001769)1.69789875
134Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.69660881
135Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.69389826
136Abnormal protein N-linked glycosylation (HP:0012347)1.69389826
137Abnormal protein glycosylation (HP:0012346)1.69389826
138Abnormal glycosylation (HP:0012345)1.69389826
139Short 5th finger (HP:0009237)1.69294489
140Duodenal stenosis (HP:0100867)1.69214651
141Small intestinal stenosis (HP:0012848)1.69214651
142Narrow forehead (HP:0000341)1.68842723
143Poor coordination (HP:0002370)1.68576352
144Abnormality of the duodenum (HP:0002246)1.67860734
145Abnormality of the phalanges of the 5th finger (HP:0004213)1.67624785
146Hyperphosphaturia (HP:0003109)1.67388081
147Poor head control (HP:0002421)1.66925963
148Sclerocornea (HP:0000647)1.66867726
149Pancreatic fibrosis (HP:0100732)1.66363471
150Muscle hypertrophy of the lower extremities (HP:0008968)1.65748697
151Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.65421702
152Hypoplasia of the pons (HP:0012110)1.65290859
153Amniotic constriction ring (HP:0009775)1.65173166
154Abnormality of placental membranes (HP:0011409)1.65173166
155Widely patent fontanelles and sutures (HP:0004492)1.64832539
156Degeneration of anterior horn cells (HP:0002398)1.64451717
157Abnormality of the anterior horn cell (HP:0006802)1.64451717
158Cerebral palsy (HP:0100021)1.64283397

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.93105738
2NEK13.13950321
3TRIM283.00861561
4BMPR1B2.93655621
5MARK12.82608764
6TGFBR12.77001648
7SIK32.56262378
8PASK2.49595067
9ARAF2.49243507
10VRK12.47563571
11DYRK22.46897387
12BCR2.46348446
13EPHB22.29615325
14ERBB32.25522228
15ZAK2.23761399
16PIM22.22428666
17MAPK132.22156491
18OBSCN2.16521931
19PLK42.14525378
20MKNK11.93492585
21BCKDK1.92300326
22MAP3K121.91814037
23TTK1.89289718
24KSR11.88678395
25MAP4K21.82132256
26CDK81.80645036
27BRAF1.80535199
28LIMK11.78548048
29NME21.77405486
30WEE11.77290912
31WNK31.71787542
32LMTK21.70102204
33GRK11.63639940
34TNIK1.56133828
35PBK1.55088119
36MAP3K41.54353792
37SRPK11.46103443
38EIF2AK31.42907999
39EPHA41.42266766
40UHMK11.41822741
41DYRK31.36031373
42PINK11.35842643
43VRK21.33787138
44MST41.29177440
45CASK1.27509137
46NUAK11.22589163
47PLK11.21016219
48PNCK1.20587946
49CSNK1G31.18756205
50TESK11.18381032
51PLK21.17774046
52YES11.17185241
53MINK11.16899731
54MUSK1.16886757
55EIF2AK21.14461797
56MAP2K61.14117719
57MATK1.11068193
58PDK21.10882687
59FRK1.08726094
60TAOK21.06487249
61ACVR1B1.06399003
62ADRBK11.03880555
63BRSK21.02910661
64NEK21.01471733
65MYLK1.00243568
66CDC70.99665753
67ADRBK20.96663903
68CCNB10.96076740
69MAP2K70.94360795
70KIT0.94072643
71STK390.88411453
72RPS6KA40.87725923
73RPS6KB20.86418323
74ATR0.82001319
75NTRK20.81588673
76TESK20.80652032
77INSRR0.77083015
78NME10.76516749
79PLK30.74938013
80ILK0.74720312
81OXSR10.74175638
82WNK40.74107547
83CDK70.73828846
84RAF10.73558096
85FLT30.73549319
86TIE10.73506683
87BUB10.73152367
88PAK40.69401268
89EIF2AK10.68956144
90CSNK1G20.68144623
91ERBB20.68092831
92TSSK60.67354759
93PKN10.66989097
94CDK190.66860753
95STK240.66662217
96PHKG20.66221063
97PHKG10.66221063
98STK38L0.65811210
99AURKA0.64484854
100CSNK1G10.64032749
101TGFBR20.63867017
102CSNK2A10.63672527
103LRRK20.63538693
104RPS6KA50.63478507
105CDK180.63065963
106PAK30.57675104
107PRKCG0.57488414
108PRKCE0.56776386
109STK30.55904413
110MAPK40.55259575
111ATM0.54887790
112CDK140.54125313
113CHEK20.53260480
114MAPKAPK50.52267833
115BRSK10.51809031
116PRKG20.49561724
117KDR0.48865441
118RPS6KB10.48295748
119CDK150.47276008
120CAMK2A0.46225086
121CDK11A0.45478592
122SCYL20.45180631
123RPS6KA20.42134538
124DAPK10.41362535
125CSNK1E0.40932346
126MAP2K10.39639376
127ABL20.39530423
128IRAK20.39189861
129RPS6KL10.38984526
130RPS6KC10.38984526
131PTK60.38436973
132CSNK2A20.38046132
133DYRK1A0.37868418
134CSNK1A1L0.36267765
135FGFR10.36027956
136CSNK1A10.34878232
137NLK0.34800954
138PAK20.34463850
139PRKACB0.31998003
140ERBB40.31205033
141AURKB0.30858371
142ERN10.29909412
143GRK70.29872032
144MKNK20.29837381

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.08042444
2Oxidative phosphorylation_Homo sapiens_hsa001903.57620333
3Parkinsons disease_Homo sapiens_hsa050123.53528346
4Proteasome_Homo sapiens_hsa030503.26291937
5DNA replication_Homo sapiens_hsa030303.13296801
6Mismatch repair_Homo sapiens_hsa034302.61692606
7Protein export_Homo sapiens_hsa030602.59256803
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.51508397
9Huntingtons disease_Homo sapiens_hsa050162.36306163
10Alzheimers disease_Homo sapiens_hsa050102.31449051
11Pyrimidine metabolism_Homo sapiens_hsa002402.14569336
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.08027750
13Fanconi anemia pathway_Homo sapiens_hsa034602.03094962
14RNA polymerase_Homo sapiens_hsa030201.95458674
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.91796911
16One carbon pool by folate_Homo sapiens_hsa006701.85632942
17Nucleotide excision repair_Homo sapiens_hsa034201.83851355
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.81783290
19Spliceosome_Homo sapiens_hsa030401.79735228
20Steroid biosynthesis_Homo sapiens_hsa001001.74699846
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.72886609
22Sulfur metabolism_Homo sapiens_hsa009201.68747534
23Base excision repair_Homo sapiens_hsa034101.67399869
24Pyruvate metabolism_Homo sapiens_hsa006201.60840540
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.47711566
26Propanoate metabolism_Homo sapiens_hsa006401.41663927
27Homologous recombination_Homo sapiens_hsa034401.39413940
28Phototransduction_Homo sapiens_hsa047441.37214299
29Fatty acid degradation_Homo sapiens_hsa000711.35429275
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33974945
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.30395318
32N-Glycan biosynthesis_Homo sapiens_hsa005101.23276323
33Cardiac muscle contraction_Homo sapiens_hsa042601.21365217
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.18417270
35Regulation of autophagy_Homo sapiens_hsa041401.16932648
36Folate biosynthesis_Homo sapiens_hsa007901.13776844
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.13131675
38Vitamin B6 metabolism_Homo sapiens_hsa007501.12753879
39Fatty acid metabolism_Homo sapiens_hsa012121.12356813
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.11488830
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10172795
42Fatty acid elongation_Homo sapiens_hsa000621.09685758
43Oocyte meiosis_Homo sapiens_hsa041141.06336689
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05105297
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04838493
46Galactose metabolism_Homo sapiens_hsa000521.04219018
47Purine metabolism_Homo sapiens_hsa002301.02843542
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01927030
49Carbon metabolism_Homo sapiens_hsa012001.00336224
50Sulfur relay system_Homo sapiens_hsa041221.00278555
51RNA degradation_Homo sapiens_hsa030180.98321468
52Butanoate metabolism_Homo sapiens_hsa006500.96530659
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.96292315
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96044470
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94412966
56Peroxisome_Homo sapiens_hsa041460.92205438
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92073282
58Chemical carcinogenesis_Homo sapiens_hsa052040.88073353
59Basal transcription factors_Homo sapiens_hsa030220.87054792
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85878494
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84070477
62Glutathione metabolism_Homo sapiens_hsa004800.82889263
63Metabolic pathways_Homo sapiens_hsa011000.81889037
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81310755
65RNA transport_Homo sapiens_hsa030130.80897629
66Arginine and proline metabolism_Homo sapiens_hsa003300.79949387
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77347406
68Nicotine addiction_Homo sapiens_hsa050330.76204822
69Nitrogen metabolism_Homo sapiens_hsa009100.75830486
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.74737442
71Cell cycle_Homo sapiens_hsa041100.73203892
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71437269
73Tyrosine metabolism_Homo sapiens_hsa003500.71069102
74Caffeine metabolism_Homo sapiens_hsa002320.69414675
75Biosynthesis of amino acids_Homo sapiens_hsa012300.68431225
76Basal cell carcinoma_Homo sapiens_hsa052170.63661270
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62508206
78Vibrio cholerae infection_Homo sapiens_hsa051100.60704164
79Retinol metabolism_Homo sapiens_hsa008300.60609640
80p53 signaling pathway_Homo sapiens_hsa041150.59964177
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58994307
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56917888
83Tryptophan metabolism_Homo sapiens_hsa003800.55554169
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.54550278
85Taste transduction_Homo sapiens_hsa047420.53564905
86Olfactory transduction_Homo sapiens_hsa047400.50416169
87Linoleic acid metabolism_Homo sapiens_hsa005910.49724520
88mRNA surveillance pathway_Homo sapiens_hsa030150.49707719
89Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48968460
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48533532
91Phenylalanine metabolism_Homo sapiens_hsa003600.48046558
92Starch and sucrose metabolism_Homo sapiens_hsa005000.47721647
93Selenocompound metabolism_Homo sapiens_hsa004500.47379705
94Circadian rhythm_Homo sapiens_hsa047100.46988598
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45538920
96Hedgehog signaling pathway_Homo sapiens_hsa043400.45334763
97Collecting duct acid secretion_Homo sapiens_hsa049660.44948128
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44898937
99Alcoholism_Homo sapiens_hsa050340.43067847
100Non-homologous end-joining_Homo sapiens_hsa034500.42935585
101Legionellosis_Homo sapiens_hsa051340.42775471
102Thyroid cancer_Homo sapiens_hsa052160.42652305
103beta-Alanine metabolism_Homo sapiens_hsa004100.41180192
104Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39912736
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39621458
106GABAergic synapse_Homo sapiens_hsa047270.37823870
107Histidine metabolism_Homo sapiens_hsa003400.35957389
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.35937957
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35797695
110Fat digestion and absorption_Homo sapiens_hsa049750.35571691
111Ether lipid metabolism_Homo sapiens_hsa005650.34274502
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33136700
113Systemic lupus erythematosus_Homo sapiens_hsa053220.31593692
114Hippo signaling pathway_Homo sapiens_hsa043900.31049108
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.30795229
116Phagosome_Homo sapiens_hsa041450.29907705
117Dopaminergic synapse_Homo sapiens_hsa047280.28556908
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28138414
119TGF-beta signaling pathway_Homo sapiens_hsa043500.26879880
120Colorectal cancer_Homo sapiens_hsa052100.24147771
121Wnt signaling pathway_Homo sapiens_hsa043100.22937049
122Bladder cancer_Homo sapiens_hsa052190.22544894
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21812971
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.21196462
125Arachidonic acid metabolism_Homo sapiens_hsa005900.21010438
126Epstein-Barr virus infection_Homo sapiens_hsa051690.19100037
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18062543
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.15913623
129PPAR signaling pathway_Homo sapiens_hsa033200.15641564

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