PRKRIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein complex disassembly (GO:0043241)5.04303873
2histone H3-K4 trimethylation (GO:0080182)4.81225660
3proteasome assembly (GO:0043248)4.78384617
4negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.73303647
5macromolecular complex disassembly (GO:0032984)4.70977856
6transcription elongation from RNA polymerase III promoter (GO:0006385)4.69876890
7termination of RNA polymerase III transcription (GO:0006386)4.69876890
8chaperone-mediated protein transport (GO:0072321)4.66273689
9ribosomal small subunit biogenesis (GO:0042274)4.63369338
10maturation of SSU-rRNA (GO:0030490)4.41865945
11protein neddylation (GO:0045116)4.39438227
12histone H2B ubiquitination (GO:0033523)4.36410343
13DNA deamination (GO:0045006)4.30511874
147-methylguanosine mRNA capping (GO:0006370)4.21016180
157-methylguanosine RNA capping (GO:0009452)4.10352614
16RNA capping (GO:0036260)4.10352614
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.04159445
18histone H3-K4 methylation (GO:0051568)3.99899050
19ATP synthesis coupled proton transport (GO:0015986)3.97884436
20energy coupled proton transport, down electrochemical gradient (GO:0015985)3.97884436
21establishment of protein localization to mitochondrial membrane (GO:0090151)3.97788435
22ribosomal large subunit biogenesis (GO:0042273)3.95645238
23nuclear-transcribed mRNA catabolic process (GO:0000956)3.92001754
24protein targeting to membrane (GO:0006612)3.82448429
25regulation of retinoic acid receptor signaling pathway (GO:0048385)3.80329790
26negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.80033221
27mRNA catabolic process (GO:0006402)3.77242001
28transcription elongation from RNA polymerase I promoter (GO:0006362)3.75921560
29GDP-mannose metabolic process (GO:0019673)3.70230336
30poly(A)+ mRNA export from nucleus (GO:0016973)3.67622724
31GTP biosynthetic process (GO:0006183)3.67109575
32viral transcription (GO:0019083)3.65584438
33ribosomal small subunit assembly (GO:0000028)3.64062046
34positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.63488312
35regulation of mitochondrial translation (GO:0070129)3.60823493
36modulation by virus of host process (GO:0019054)3.57786748
37translational termination (GO:0006415)3.56357160
38mitochondrion transport along microtubule (GO:0047497)3.55422519
39establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.55422519
40mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.53908675
41ribonucleoprotein complex biogenesis (GO:0022613)3.53050158
42protein complex biogenesis (GO:0070271)3.52879853
43negative regulation of ligase activity (GO:0051352)3.51023771
44negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.51023771
45anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.50914042
46regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.49468920
47termination of RNA polymerase I transcription (GO:0006363)3.47819241
48DNA damage response, detection of DNA damage (GO:0042769)3.45640279
49deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.45274224
50microtubule depolymerization (GO:0007019)3.44359246
51RNA catabolic process (GO:0006401)3.43684248
52mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.41933656
53mitochondrial respiratory chain complex I assembly (GO:0032981)3.41933656
54NADH dehydrogenase complex assembly (GO:0010257)3.41933656
55regulation of cellular amino acid metabolic process (GO:0006521)3.40392422
56negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.38080138
57transcription-coupled nucleotide-excision repair (GO:0006283)3.37109330
58DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.36532794
59transcription from RNA polymerase I promoter (GO:0006360)3.36482106
60rRNA modification (GO:0000154)3.35306649
61guanosine-containing compound biosynthetic process (GO:1901070)3.34225604
62signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.33454742
63signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.33454742
64signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.33454742
65regulation of spindle checkpoint (GO:0090231)3.31497561
66cellular component biogenesis (GO:0044085)3.29323723
67protein targeting to mitochondrion (GO:0006626)3.28800863
68spliceosomal snRNP assembly (GO:0000387)3.28649608
69signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.28003146
70intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.28003146
71establishment of mitochondrion localization (GO:0051654)3.24843664
72signal transduction involved in DNA damage checkpoint (GO:0072422)3.24364198
73signal transduction involved in DNA integrity checkpoint (GO:0072401)3.24364198
74signal transduction involved in cell cycle checkpoint (GO:0072395)3.24226336
75establishment of protein localization to mitochondrion (GO:0072655)3.23077902
76kinetochore assembly (GO:0051382)3.22696262
77translation (GO:0006412)3.21367490
78cotranslational protein targeting to membrane (GO:0006613)3.20077101
79L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.19982015
80rRNA processing (GO:0006364)3.17234791
81SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.16419215
82positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.14158852
83UTP biosynthetic process (GO:0006228)3.14065526
84negative regulation of erythrocyte differentiation (GO:0045647)3.13560325
85cullin deneddylation (GO:0010388)3.13119674
86transcription elongation from RNA polymerase II promoter (GO:0006368)3.12273506
87mitochondrial respiratory chain complex assembly (GO:0033108)3.12025070
88translational initiation (GO:0006413)3.11899723
89protein targeting to ER (GO:0045047)3.11866202
90mitotic metaphase plate congression (GO:0007080)3.08577285
91rRNA metabolic process (GO:0016072)3.08308141
92nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.08294122
93antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.08019691
94cellular protein complex disassembly (GO:0043624)3.07226475
95transcription from mitochondrial promoter (GO:0006390)3.07066024
96long-chain fatty acid biosynthetic process (GO:0042759)3.07039301
97DNA-templated transcription, elongation (GO:0006354)3.05654422
98protein deneddylation (GO:0000338)3.02373607
99transcription initiation from RNA polymerase I promoter (GO:0006361)3.01774273
100positive regulation of ligase activity (GO:0051351)3.01579793
101ribosome biogenesis (GO:0042254)3.00768920
102translational elongation (GO:0006414)3.00071662
103intracellular estrogen receptor signaling pathway (GO:0030520)3.00026069
104regulation of chromatin binding (GO:0035561)2.97952671
105exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.97933036
106regulation of spindle organization (GO:0090224)2.97515997
107establishment of protein localization to endoplasmic reticulum (GO:0072599)2.97121483
108metallo-sulfur cluster assembly (GO:0031163)2.96042162
109iron-sulfur cluster assembly (GO:0016226)2.96042162
110negative regulation of RNA splicing (GO:0033119)2.95799829
111base-excision repair, AP site formation (GO:0006285)2.95131715
112histone H3-K9 modification (GO:0061647)2.94917784
113protein localization to endoplasmic reticulum (GO:0070972)2.93924764
114protein localization to mitochondrion (GO:0070585)2.92156016
115pyrimidine nucleotide catabolic process (GO:0006244)2.91042982
116positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.90737302
117spliceosomal complex assembly (GO:0000245)2.90406717
118respiratory electron transport chain (GO:0022904)2.90006340
119viral life cycle (GO:0019058)2.89430481
120histone H3-K9 methylation (GO:0051567)2.88910984
121kinetochore organization (GO:0051383)2.87975342
122cell migration in hindbrain (GO:0021535)2.87934840
123positive regulation of viral transcription (GO:0050434)2.87917128
124antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.86199429
125peptidyl-lysine trimethylation (GO:0018023)2.84515722
126peptidyl-histidine modification (GO:0018202)2.84482540
127negative regulation of telomere maintenance (GO:0032205)2.83515506
128electron transport chain (GO:0022900)2.83426583
129positive regulation of protein homodimerization activity (GO:0090073)2.82701075
130CENP-A containing nucleosome assembly (GO:0034080)2.81175594
131modulation by symbiont of host cellular process (GO:0044068)2.80872494
132negative regulation of DNA-templated transcription, elongation (GO:0032785)2.80730180
133microtubule polymerization or depolymerization (GO:0031109)2.79058418
134nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.77623847
135negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.77145718
136formation of translation preinitiation complex (GO:0001731)2.76447541
137negative regulation of glial cell proliferation (GO:0060253)2.76396545
138histone H3-K9 demethylation (GO:0033169)2.75817436
139positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.74589805
140establishment of protein localization to membrane (GO:0090150)2.74448751
141RNA splicing, via transesterification reactions (GO:0000375)2.74132013
142negative regulation of mRNA processing (GO:0050686)2.73335506
143sensory perception of taste (GO:0050909)2.71872044
144pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.71215260
145positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.70858982
146modulation by virus of host morphology or physiology (GO:0019048)2.64775328
147pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.64748661
148synaptonemal complex assembly (GO:0007130)2.63887728
149regulation of cell maturation (GO:1903429)2.63875080
150planar cell polarity pathway involved in neural tube closure (GO:0090179)2.63807142
151mRNA splicing, via spliceosome (GO:0000398)2.63725474
152RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.63725474
153ncRNA 3-end processing (GO:0043628)2.62547266
154termination of RNA polymerase II transcription (GO:0006369)2.60972077
155Arp2/3 complex-mediated actin nucleation (GO:0034314)2.60080533
156protein-DNA complex disassembly (GO:0032986)2.59076913
157nucleosome disassembly (GO:0006337)2.59076913
158regulation of histone H3-K4 methylation (GO:0051569)2.58476038
159centrosome localization (GO:0051642)2.56786390
160negative regulation of histone methylation (GO:0031061)2.56406564
161neuron fate determination (GO:0048664)2.54149324
162histone H4 deacetylation (GO:0070933)2.52264442
163epithelial cell fate commitment (GO:0072148)2.49655851
164regulation of cytokine production involved in inflammatory response (GO:1900015)2.49085240
165positive regulation of DNA-templated transcription, elongation (GO:0032786)2.48145878
166rRNA methylation (GO:0031167)2.47560546
167protein insertion into membrane (GO:0051205)2.46924803
168mitotic chromosome condensation (GO:0007076)2.45513773
169mRNA stabilization (GO:0048255)2.44599987
170RNA stabilization (GO:0043489)2.44599987
171protein kinase C signaling (GO:0070528)2.40956704
172regulation of NFAT protein import into nucleus (GO:0051532)2.40272780
173regulation of histone methylation (GO:0031060)2.40149952

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.88186156
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.29493546
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.16335048
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.09212771
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.02612248
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.90495529
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.88419317
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.53393239
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.36443398
10VDR_21846776_ChIP-Seq_THP-1_Human3.30398311
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.23468156
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.19550036
13CREB1_15753290_ChIP-ChIP_HEK293T_Human3.10129973
14MYC_22102868_ChIP-Seq_BL_Human2.89048042
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.81617858
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.77601561
17E2F7_22180533_ChIP-Seq_HELA_Human2.72128233
18TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.65880153
19* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.53135270
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.44317792
21VDR_23849224_ChIP-Seq_CD4+_Human2.43053424
22* LXR_22292898_ChIP-Seq_THP-1_Human2.39832047
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.36816413
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.29467265
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.19531466
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.15883926
27ELK1_19687146_ChIP-ChIP_HELA_Human2.08257969
28XRN2_22483619_ChIP-Seq_HELA_Human2.06131629
29DCP1A_22483619_ChIP-Seq_HELA_Human2.05675529
30YY1_21170310_ChIP-Seq_MESCs_Mouse2.02144590
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.99455780
32P68_20966046_ChIP-Seq_HELA_Human1.98804156
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.98777940
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.96443629
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.94453936
36* FOXP3_21729870_ChIP-Seq_TREG_Human1.92443143
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.91133067
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.89864549
39TTF2_22483619_ChIP-Seq_HELA_Human1.89798491
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.89412353
41KDM2B_26808549_Chip-Seq_DND41_Human1.87972789
42EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.86863497
43CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.85160716
44DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.81254463
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.79954651
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78918685
47MAF_26560356_Chip-Seq_TH2_Human1.78601142
48GABP_19822575_ChIP-Seq_HepG2_Human1.75460976
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.75189658
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75029031
51EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72444969
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70706251
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69220873
54ELF1_20517297_ChIP-Seq_JURKAT_Human1.65439584
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.65233765
56ELK3_25401928_ChIP-Seq_HUVEC_Human1.64561300
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64427656
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62147371
59TET1_21451524_ChIP-Seq_MESCs_Mouse1.61981611
60TCF7_22412390_ChIP-Seq_EML_Mouse1.59152698
61STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57483124
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55153989
63BCL6_27268052_Chip-Seq_Bcells_Human1.51112246
64ELK1_22589737_ChIP-Seq_MCF10A_Human1.50638740
65SA1_27219007_Chip-Seq_ERYTHROID_Human1.50057063
66RACK7_27058665_Chip-Seq_MCF-7_Human1.49565488
67VDR_24763502_ChIP-Seq_THP-1_Human1.47794221
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.46602853
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.45498558
70UTX_26944678_Chip-Seq_JUKART_Human1.44522351
71KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44111295
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43709781
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43410478
74MAF_26560356_Chip-Seq_TH1_Human1.41105834
75BCOR_27268052_Chip-Seq_Bcells_Human1.40105498
76* SMC4_20622854_ChIP-Seq_HELA_Human1.40046496
77CTCF_27219007_Chip-Seq_ERYTHROID_Human1.39872611
78MYCN_18555785_ChIP-Seq_MESCs_Mouse1.39595218
79* FOXP1_21924763_ChIP-Seq_HESCs_Human1.37256623
80* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37108909
81VDR_22108803_ChIP-Seq_LS180_Human1.36391849
82FOXM1_23109430_ChIP-Seq_U2OS_Human1.35677818
83* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35575840
84HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35506084
85MYC_18940864_ChIP-ChIP_HL60_Human1.34540799
86PHF8_20622854_ChIP-Seq_HELA_Human1.34037471
87SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32515362
88NOTCH1_21737748_ChIP-Seq_TLL_Human1.32505977
89DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.31832992
90E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.31819156
91NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31000357
92* E2F1_20622854_ChIP-Seq_HELA_Human1.29076416
93* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.28845508
94TP63_19390658_ChIP-ChIP_HaCaT_Human1.27863621
95* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.27669758
96CTCF_27219007_Chip-Seq_Bcells_Human1.27292650
97IRF1_19129219_ChIP-ChIP_H3396_Human1.27287601
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.26715898
99* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25707498
100ZNF263_19887448_ChIP-Seq_K562_Human1.25496456
101YY1_22570637_ChIP-Seq_MALME-3M_Human1.24435115
102* CTCF_26484167_Chip-Seq_Bcells_Mouse1.23743530
103NCOR1_26117541_ChIP-Seq_K562_Human1.23571987
104PU.1_20513432_ChIP-Seq_Bcells_Mouse1.23167483
105KDM2B_26808549_Chip-Seq_K562_Human1.22172453
106CREB1_26743006_Chip-Seq_LNCaP_Human1.20707712
107* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20702293
108CTCF_21964334_Chip-Seq_Bcells_Human1.18763180
109KDM2B_26808549_Chip-Seq_JURKAT_Human1.18591826
110ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18514937
111* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18329228
112UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17597037
113RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15567455
114SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13966680
115EZH2_22144423_ChIP-Seq_EOC_Human1.11767827
116RARB_24833708_ChIP-Seq_LIVER_Mouse1.10843887
117KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08944000
118MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.08731316
119CTCF_21964334_ChIP-Seq_BJAB-B_Human1.07769005
120SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06844431
121PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06057391
122PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03136956
123SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.01895494
124SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99633532
125* SOX2_16153702_ChIP-ChIP_HESCs_Human0.98485135
126CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95128027
127TAF15_26573619_Chip-Seq_HEK293_Human0.92537408
128FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91976560
129GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91117413
130FUS_26573619_Chip-Seq_HEK293_Human0.88960452
131ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87091057
132KAP1_22055183_ChIP-Seq_ESCs_Mouse0.86891216
133NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.85902171
134SOX17_20123909_ChIP-Seq_XEN_Mouse0.85805211
135FLI1_27457419_Chip-Seq_LIVER_Mouse0.85586222
136PCGF2_27294783_Chip-Seq_ESCs_Mouse0.84752607
137KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.83691100
138KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.83691100
139KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.83691100
140SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83316821
141* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.83229612
142BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83193368
143EWS_26573619_Chip-Seq_HEK293_Human0.82573380
144CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.82027474
145KDM5A_27292631_Chip-Seq_BREAST_Human0.79726633
146E2F1_21310950_ChIP-Seq_MCF-7_Human0.79612039
147FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.76261580
148RNF2_27304074_Chip-Seq_NSC_Mouse0.76027405
149CTCF_18555785_ChIP-Seq_MESCs_Mouse0.75998887
150ERG_20887958_ChIP-Seq_HPC-7_Mouse0.75628155
151CIITA_25753668_ChIP-Seq_RAJI_Human0.72789275
152CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.65991702
153E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.65704140
154CBX2_27304074_Chip-Seq_ESCs_Mouse0.64844284
155* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.64631462
156KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.63215671
157SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.63044702
158GATA1_26923725_Chip-Seq_HPCs_Mouse0.61962295

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.71669036
2MP0001529_abnormal_vocalization3.27565745
3MP0003787_abnormal_imprinting2.83303457
4MP0001188_hyperpigmentation2.70511553
5MP0006292_abnormal_olfactory_placode2.68360548
6MP0009379_abnormal_foot_pigmentation2.67853420
7MP0003718_maternal_effect2.67376011
8MP0009278_abnormal_bone_marrow2.64196920
9MP0003136_yellow_coat_color2.50770657
10MP0002102_abnormal_ear_morphology2.48601688
11MP0003880_abnormal_central_pattern2.47931604
12MP0003111_abnormal_nucleus_morphology2.31418970
13MP0008058_abnormal_DNA_repair2.29715347
14MP0008932_abnormal_embryonic_tissue2.28664496
15MP0002249_abnormal_larynx_morphology2.13422677
16MP0001502_abnormal_circadian_rhythm2.13380712
17MP0008995_early_reproductive_senescence2.12560963
18MP0008789_abnormal_olfactory_epithelium2.10855624
19MP0006276_abnormal_autonomic_nervous2.10528731
20MP0004957_abnormal_blastocyst_morpholog2.09973665
21MP0001905_abnormal_dopamine_level2.07622446
22MP0010094_abnormal_chromosome_stability2.01913674
23MP0000015_abnormal_ear_pigmentation1.97092382
24MP0008057_abnormal_DNA_replication1.94762653
25MP0001986_abnormal_taste_sensitivity1.91264495
26MP0003077_abnormal_cell_cycle1.80856381
27MP0008260_abnormal_autophagy1.80344330
28MP0008877_abnormal_DNA_methylation1.79380554
29MP0005409_darkened_coat_color1.77165868
30MP0005058_abnormal_lysosome_morphology1.76550974
31MP0002638_abnormal_pupillary_reflex1.69231128
32MP0005499_abnormal_olfactory_system1.65973854
33MP0005394_taste/olfaction_phenotype1.65973854
34MP0002160_abnormal_reproductive_system1.65045629
35MP0003786_premature_aging1.64654096
36MP0003315_abnormal_perineum_morphology1.58814317
37MP0004859_abnormal_synaptic_plasticity1.57687350
38MP0005171_absent_coat_pigmentation1.50237925
39MP0004381_abnormal_hair_follicle1.49530541
40MP0002277_abnormal_respiratory_mucosa1.49322707
41MP0002163_abnormal_gland_morphology1.47338095
42MP0002653_abnormal_ependyma_morphology1.39954398
43MP0004142_abnormal_muscle_tone1.38388778
44MP0003938_abnormal_ear_development1.37555901
45MP0005076_abnormal_cell_differentiation1.37421277
46MP0000372_irregular_coat_pigmentation1.36261463
47MP0002751_abnormal_autonomic_nervous1.34461989
48MP0003172_abnormal_lysosome_physiology1.33309402
49MP0001984_abnormal_olfaction1.30302963
50MP0002132_abnormal_respiratory_system1.29969999
51MP0002736_abnormal_nociception_after1.28093455
52MP0002938_white_spotting1.27888820
53MP0002735_abnormal_chemical_nociception1.27511996
54MP0000566_synostosis1.27191168
55MP0001968_abnormal_touch/_nociception1.26932811
56MP0000750_abnormal_muscle_regeneration1.25946813
57MP0000678_abnormal_parathyroid_gland1.25688253
58MP0003941_abnormal_skin_development1.19414440
59MP0002184_abnormal_innervation1.17920725
60MP0008007_abnormal_cellular_replicative1.17230263
61MP0002734_abnormal_mechanical_nocicepti1.16938781
62MP0001485_abnormal_pinna_reflex1.16049060
63MP0005451_abnormal_body_composition1.13048534
64MP0003183_abnormal_peptide_metabolism1.12457357
65MP0000778_abnormal_nervous_system1.12211354
66MP0005379_endocrine/exocrine_gland_phen1.11472877
67MP0005645_abnormal_hypothalamus_physiol1.11063253
68MP0000026_abnormal_inner_ear1.08624939
69MP0001727_abnormal_embryo_implantation1.08571538
70MP0002272_abnormal_nervous_system1.05456605
71MP0004742_abnormal_vestibular_system1.05090459
72MP0005389_reproductive_system_phenotype1.04881872
73MP0009333_abnormal_splenocyte_physiolog1.04339098
74MP0003303_peritoneal_inflammation1.03993194
75MP0003436_decreased_susceptibility_to1.03625639
76MP0003123_paternal_imprinting1.01567980
77MP0009046_muscle_twitch1.01436368
78MP0001346_abnormal_lacrimal_gland1.00836935
79MP0002752_abnormal_somatic_nervous0.99996030
80MP0005174_abnormal_tail_pigmentation0.99403641
81MP0003011_delayed_dark_adaptation0.99143372
82MP0003763_abnormal_thymus_physiology0.98205013
83MP0002210_abnormal_sex_determination0.98173219
84MP0003937_abnormal_limbs/digits/tail_de0.97882671
85MP0005410_abnormal_fertilization0.95715564
86MP0000490_abnormal_crypts_of0.94999778
87MP0004133_heterotaxia0.93041865
88MP0009672_abnormal_birth_weight0.92165463
89MP0002398_abnormal_bone_marrow0.91817302
90MP0001970_abnormal_pain_threshold0.91705143
91MP0002064_seizures0.90586492
92MP0009384_cardiac_valve_regurgitation0.89220291
93MP0005387_immune_system_phenotype0.88138523
94MP0001790_abnormal_immune_system0.88138523
95MP0000537_abnormal_urethra_morphology0.87853390
96MP0000703_abnormal_thymus_morphology0.87667421
97MP0001486_abnormal_startle_reflex0.86228021
98MP0000049_abnormal_middle_ear0.86100480
99MP0003942_abnormal_urinary_system0.85115541
100MP0002095_abnormal_skin_pigmentation0.85095654
101MP0005423_abnormal_somatic_nervous0.84991348
102MP0009745_abnormal_behavioral_response0.84405436
103MP0003121_genomic_imprinting0.84366945
104MP0004858_abnormal_nervous_system0.84098167
105MP0005501_abnormal_skin_physiology0.83571294
106MP0002089_abnormal_postnatal_growth/wei0.83221487
107MP0001730_embryonic_growth_arrest0.83203810
108MP0001963_abnormal_hearing_physiology0.81712209
109MP0006072_abnormal_retinal_apoptosis0.81695872
110MP0001542_abnormal_bone_strength0.81464809
111MP0001800_abnormal_humoral_immune0.81456833
112MP0000955_abnormal_spinal_cord0.81346624
113MP0010386_abnormal_urinary_bladder0.80667906
114MP0006036_abnormal_mitochondrial_physio0.79454495
115MP0001929_abnormal_gametogenesis0.79413619
116MP0002067_abnormal_sensory_capabilities0.78753440
117MP0003453_abnormal_keratinocyte_physiol0.77565729
118MP0002572_abnormal_emotion/affect_behav0.77135125
119MP0003698_abnormal_male_reproductive0.76911106
120MP0004270_analgesia0.76775533
121MP0000716_abnormal_immune_system0.76374234
122MP0000631_abnormal_neuroendocrine_gland0.75607714
123MP0001764_abnormal_homeostasis0.75580762
124MP0001849_ear_inflammation0.75463744
125MP0002177_abnormal_outer_ear0.75139355
126MP0002116_abnormal_craniofacial_bone0.75076901
127MP0002152_abnormal_brain_morphology0.74621165
128MP0010030_abnormal_orbit_morphology0.73835472
129MP0001145_abnormal_male_reproductive0.73669191
130MP0002080_prenatal_lethality0.73474944
131MP0002429_abnormal_blood_cell0.73343661
132MP0003699_abnormal_female_reproductive0.72901849
133MP0000689_abnormal_spleen_morphology0.72511006
134MP0000733_abnormal_muscle_development0.72443375
135MP0002882_abnormal_neuron_morphology0.72374031
136MP0004808_abnormal_hematopoietic_stem0.71582437
137MP0003861_abnormal_nervous_system0.71125041
138MP0002161_abnormal_fertility/fecundity0.71114093
139MP0002722_abnormal_immune_system0.70650463
140MP0000313_abnormal_cell_death0.70163971
141MP0003122_maternal_imprinting0.70025819
142MP0002557_abnormal_social/conspecific_i0.69932052
143MP0006035_abnormal_mitochondrial_morpho0.69832785
144MP0001697_abnormal_embryo_size0.69100846
145MP0005408_hypopigmentation0.68344460
146MP0000653_abnormal_sex_gland0.67902243
147MP0000358_abnormal_cell_content/0.67628794
148MP0005551_abnormal_eye_electrophysiolog0.67214746
149MP0000350_abnormal_cell_proliferation0.65821074

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.12862545
2Increased hepatocellular lipid droplets (HP:0006565)3.72755728
3Ulnar bowing (HP:0003031)3.68363840
4Mitochondrial inheritance (HP:0001427)3.65224513
5Intestinal fistula (HP:0100819)3.62355824
6Rib fusion (HP:0000902)3.57220854
7Abnormal mitochondria in muscle tissue (HP:0008316)3.46027242
8Turricephaly (HP:0000262)3.44961512
9Birth length less than 3rd percentile (HP:0003561)3.43836988
10Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.42391363
11Agammaglobulinemia (HP:0004432)3.40447244
12Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.36463191
133-Methylglutaconic aciduria (HP:0003535)3.31154001
14Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.30294749
15Progressive macrocephaly (HP:0004481)3.27154096
16Breast hypoplasia (HP:0003187)3.17922300
17Renal Fanconi syndrome (HP:0001994)3.16208678
18Parakeratosis (HP:0001036)3.11031863
19Abnormality of the aortic arch (HP:0012303)3.10624075
20Reticulocytopenia (HP:0001896)3.10111081
21Testicular atrophy (HP:0000029)3.07142529
22Cerebral hypomyelination (HP:0006808)3.02887517
23Increased CSF lactate (HP:0002490)3.02047530
24Chromosomal breakage induced by crosslinking agents (HP:0003221)2.97548751
25Acute encephalopathy (HP:0006846)2.95599143
26Supernumerary ribs (HP:0005815)2.90298891
27Lipid accumulation in hepatocytes (HP:0006561)2.87886432
28Abnormality of cells of the erythroid lineage (HP:0012130)2.87515238
29Truncus arteriosus (HP:0001660)2.80878297
30Hepatocellular necrosis (HP:0001404)2.80721488
31Partial duplication of thumb phalanx (HP:0009944)2.78336526
32Exertional dyspnea (HP:0002875)2.76589076
33Rectovaginal fistula (HP:0000143)2.74114291
34Rectal fistula (HP:0100590)2.74114291
35Macrocytic anemia (HP:0001972)2.72808315
36Facial hemangioma (HP:0000329)2.71371647
37Vaginal fistula (HP:0004320)2.70294792
38Supernumerary bones of the axial skeleton (HP:0009144)2.68530638
39Annular pancreas (HP:0001734)2.66146513
40Broad distal phalanx of finger (HP:0009836)2.65364383
41Patellar aplasia (HP:0006443)2.63370962
42Hyperacusis (HP:0010780)2.63077324
43Microvesicular hepatic steatosis (HP:0001414)2.61362262
44Chromsome breakage (HP:0040012)2.61307036
45Obstructive sleep apnea (HP:0002870)2.58453932
46Aplasia/Hypoplasia of the patella (HP:0006498)2.55193711
47Colitis (HP:0002583)2.54180347
48Meckel diverticulum (HP:0002245)2.52537756
49Cellulitis (HP:0100658)2.51772524
50Broad face (HP:0000283)2.48954780
51Adrenal hypoplasia (HP:0000835)2.48822823
52Hypertensive crisis (HP:0100735)2.45656438
53Abnormality of the ileum (HP:0001549)2.44337077
54Medial flaring of the eyebrow (HP:0010747)2.43175057
55Abnormal number of erythroid precursors (HP:0012131)2.41636852
56Abnormality of the preputium (HP:0100587)2.39361965
57Duplicated collecting system (HP:0000081)2.37222245
58Congenital ichthyosiform erythroderma (HP:0007431)2.36265701
59Abnormality of glycolysis (HP:0004366)2.34542398
60Increased serum pyruvate (HP:0003542)2.34542398
61Carpal bone hypoplasia (HP:0001498)2.34363540
62Triphalangeal thumb (HP:0001199)2.32122320
63Biconcave vertebral bodies (HP:0004586)2.30541223
64Partial duplication of the phalanx of hand (HP:0009999)2.30516724
65Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.29644336
66Decreased activity of mitochondrial respiratory chain (HP:0008972)2.29644336
67Gait imbalance (HP:0002141)2.29548096
68Respiratory difficulties (HP:0002880)2.28397099
69Horseshoe kidney (HP:0000085)2.27702390
70Long palpebral fissure (HP:0000637)2.27630878
71Increased serum lactate (HP:0002151)2.25668925
72Optic nerve coloboma (HP:0000588)2.25370789
73Hyperthyroidism (HP:0000836)2.25097949
74Increased IgE level (HP:0003212)2.22917021
75Optic disc pallor (HP:0000543)2.22608589
76Abnormality of reticulocytes (HP:0004312)2.22593470
77Pallor (HP:0000980)2.22576685
78Abnormality of the fingertips (HP:0001211)2.22237805
79Congenital primary aphakia (HP:0007707)2.22187537
80Hypoplastic pelvis (HP:0008839)2.22180924
81Thoracic kyphosis (HP:0002942)2.22095061
82Absent radius (HP:0003974)2.20882553
83Squamous cell carcinoma (HP:0002860)2.20169734
84Aplasia/Hypoplasia involving the musculature (HP:0001460)2.19484204
85Exercise intolerance (HP:0003546)2.18312883
86Poikiloderma (HP:0001029)2.17470516
87Seborrheic dermatitis (HP:0001051)2.17413939
88Amniotic constriction ring (HP:0009775)2.17136003
89Abnormality of placental membranes (HP:0011409)2.17136003
90Panhypogammaglobulinemia (HP:0003139)2.16324365
91Nephrogenic diabetes insipidus (HP:0009806)2.16210543
92Progressive muscle weakness (HP:0003323)2.13433865
93Type I transferrin isoform profile (HP:0003642)2.11961084
94Aplasia/Hypoplasia of the sacrum (HP:0008517)2.11791453
95Proximal placement of thumb (HP:0009623)2.11030831
96Abnormality of the renal collecting system (HP:0004742)2.08641680
97Pointed chin (HP:0000307)2.08246628
98Increased intramyocellular lipid droplets (HP:0012240)2.08243257
99Aplasia involving forearm bones (HP:0009822)2.07970694
100Absent forearm bone (HP:0003953)2.07970694
101Vaginal atresia (HP:0000148)2.07416787
102Aplasia of the musculature (HP:0100854)2.06944429
103Aplasia/Hypoplasia of the uvula (HP:0010293)2.06299804
104Abnormality of the labia minora (HP:0012880)2.06261835
105Leukodystrophy (HP:0002415)2.06236158
106Vertebral arch anomaly (HP:0008438)2.01669609
107Hypoplasia of the radius (HP:0002984)2.01393742
108Overriding aorta (HP:0002623)2.01307670
109Absent thumb (HP:0009777)2.00408161
110Genital tract atresia (HP:0001827)2.00268881
111Abnormality of cochlea (HP:0000375)1.99845588
112Increased nuchal translucency (HP:0010880)1.99424497
113Impulsivity (HP:0100710)1.97166986
114Respiratory failure (HP:0002878)1.97026041
115Chronic obstructive pulmonary disease (HP:0006510)1.96873545
116Obstructive lung disease (HP:0006536)1.96873545
117Aplasia/hypoplasia of the uterus (HP:0008684)1.96589977
118Thin bony cortex (HP:0002753)1.96533762
119Myopathic facies (HP:0002058)1.96431888
120Hepatic necrosis (HP:0002605)1.94886635
121Abnormality of the thoracic spine (HP:0100711)1.94370980
122Septo-optic dysplasia (HP:0100842)1.93531877
123Abnormality of the septum pellucidum (HP:0007375)1.93188172
124Cleft eyelid (HP:0000625)1.91011309
125Severe visual impairment (HP:0001141)1.90945158
126Bony spicule pigmentary retinopathy (HP:0007737)1.90701586
127Atresia of the external auditory canal (HP:0000413)1.89528863
128Abnormality of renal resorption (HP:0011038)1.88704382
129Insomnia (HP:0100785)1.88685496
130Abnormal lung lobation (HP:0002101)1.88235631
131Truncal obesity (HP:0001956)1.87826198
132Bowing of the arm (HP:0006488)1.87540872
133Bowed forearm bones (HP:0003956)1.87540872
134Concave nail (HP:0001598)1.86986479
135Stenosis of the external auditory canal (HP:0000402)1.86271790
136Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85467355
137Abnormality of alanine metabolism (HP:0010916)1.85467355
138Hyperalaninemia (HP:0003348)1.85467355
139Abnormal hair whorl (HP:0010721)1.84688128
140Lactic acidosis (HP:0003128)1.83909022
141Increased muscle lipid content (HP:0009058)1.83888345
142Abnormal respiratory epithelium morphology (HP:0012253)1.83364036
143Abnormal respiratory motile cilium morphology (HP:0005938)1.83364036
144Atelectasis (HP:0100750)1.83297743
145Dry hair (HP:0011359)1.82923682
146Abnormal number of incisors (HP:0011064)1.82883859
147Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.81255812
148Poor coordination (HP:0002370)1.80845029
149Nasolacrimal duct obstruction (HP:0000579)1.79812608
150Rough bone trabeculation (HP:0100670)1.79434227
151Supernumerary spleens (HP:0009799)1.79420622
152Small intestinal stenosis (HP:0012848)1.79048820
153Duodenal stenosis (HP:0100867)1.79048820
154Morphological abnormality of the inner ear (HP:0011390)1.77035174
155Elfin facies (HP:0004428)1.76966152
156Aganglionic megacolon (HP:0002251)1.76630833
157Preauricular skin tag (HP:0000384)1.76025335
158High anterior hairline (HP:0009890)1.75938811
159Type 2 muscle fiber atrophy (HP:0003554)1.75723866
160Esotropia (HP:0000565)1.75594407
161Bowel incontinence (HP:0002607)1.75454968
162Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.74794906
163Hypoplasia of the capital femoral epiphysis (HP:0003090)1.74335106
164Patellar dislocation (HP:0002999)1.73997642
165Septate vagina (HP:0001153)1.73936575
166Mediastinal lymphadenopathy (HP:0100721)1.73530930
167Abnormality of small intestinal villus morphology (HP:0011472)1.73199942
168Villous atrophy (HP:0011473)1.73199942
169Eczematoid dermatitis (HP:0000976)1.72768785
170Pancreatic cysts (HP:0001737)1.72577186
171Cholecystitis (HP:0001082)1.70310220
172Abnormal gallbladder physiology (HP:0012438)1.70310220
173J-shaped sella turcica (HP:0002680)1.70180177
174Aplasia/Hypoplasia of the earlobes (HP:0009906)1.69949851
175Delusions (HP:0000746)1.69774065
176Cervical subluxation (HP:0003308)1.69313630
177Hemorrhage of the eye (HP:0011885)1.68489911
178Bell-shaped thorax (HP:0001591)1.68457679
179Hypoparathyroidism (HP:0000829)1.67833596
180Urethral obstruction (HP:0000796)1.66497629
181Deviation of the thumb (HP:0009603)1.65785940

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K96.03146491
2BUB14.24227256
3STK163.27866530
4SIK13.00542636
5SRPK12.83629780
6TLK12.82936609
7TRIB32.78715191
8NME22.73992164
9VRK22.66881146
10SMG12.65430840
11MAPK152.62042639
12SIK22.55587436
13PLK42.39673860
14CASK2.26652116
15NME12.26252967
16WEE12.10162525
17SIK32.08003971
18EIF2AK11.98265404
19ARAF1.97595511
20PIM21.96162028
21MKNK21.93737056
22MAP3K101.93477977
23BRAF1.91456174
24CDK121.88481949
25TAF11.87428874
26BCR1.87324554
27IRAK31.83145504
28VRK11.81592193
29ZAK1.80344259
30AKT31.77959875
31MAP4K11.75773780
32NTRK21.74894046
33TSSK61.65868425
34MAP3K121.62848512
35ERN11.62165326
36PNCK1.60345045
37MKNK11.59965615
38TYRO31.58510305
39MAP2K31.58454891
40MAP3K111.58166965
41PLK31.49078025
42DYRK21.48638371
43PRKD21.47907115
44TESK21.46436913
45EIF2AK31.45990714
46CCNB11.41097355
47MST41.36775794
48DYRK1B1.32934784
49MAP3K131.30312454
50BRSK21.29321583
51TTK1.27199680
52PLK11.25247095
53MAPK131.24715957
54MARK11.22159025
55GRK51.19205107
56LIMK11.18375317
57AURKA1.17239633
58IRAK41.13748574
59MARK21.13465415
60PBK1.12562945
61PRPF4B1.11010662
62KSR21.10397578
63LRRK21.05737425
64IRAK21.03912929
65EIF2AK21.01774174
66EPHA21.01337658
67MAPKAPK51.00119296
68BMPR1B0.99379837
69EEF2K0.97929780
70RPS6KA50.96020148
71IRAK10.94237925
72ADRBK20.92727741
73ICK0.92597334
74PLK20.91419440
75DYRK30.89771301
76BMPR20.89300895
77CDK90.88882417
78CHEK20.88431280
79TBK10.87509376
80GRK60.87177258
81PRKCI0.87081555
82STK390.82514469
83YES10.80246258
84DDR20.79831342
85GRK70.79532210
86RPS6KC10.78270998
87RPS6KL10.78270998
88UHMK10.76304884
89CDK80.75337804
90TAOK10.75197860
91NEK60.75187225
92CSNK1G30.74545997
93TNK20.74528009
94MAP2K70.74241532
95MAPK120.73909429
96AURKB0.73420630
97STK38L0.73068070
98CDK40.73061250
99CDK11A0.68615498
100OXSR10.68544342
101CAMK2B0.66864794
102MTOR0.66290701
103RIPK10.65316712
104TYK20.65073105
105BRSK10.64606898
106RPS6KB20.60870561
107RPS6KA60.60843536
108TNIK0.59450197
109CSNK2A10.59130214
110PASK0.59053687
111BMX0.58171085
112CDC42BPA0.58138052
113CDC70.58098800
114CDK20.57738172
115CSNK1G10.57623937
116TXK0.57618550
117PKN10.57365011
118PAK10.56250984
119ACVR1B0.56212532
120MAP3K10.54303208
121RAF10.53041499
122PRKD30.52529959
123RPS6KA20.52177318
124CSNK2A20.51509729
125CDK190.51271720
126TAOK20.50555567
127CDK150.50433617
128GRK10.49768346
129RPS6KA10.49163856
130MAPK40.49154831
131BLK0.47601849
132KSR10.46683175
133ABL20.46646209
134NEK20.46615267
135MAP3K30.44779277
136PKN20.44657726
137DAPK30.44480510
138IKBKE0.43784728
139EPHB20.42866228
140MUSK0.42751043
141CSNK1A1L0.42578834
142MAP3K140.41651379
143FGR0.41461710
144MAPK80.41240541
145CHUK0.41166954
146CHEK10.38838943
147RIPK40.38684166
148CDK180.38599538
149CAMK2G0.38194917
150STK40.37040755
151IKBKB0.36447636
152ADRBK10.36407831
153BTK0.35090597
154ATR0.34077191
155CDK140.33573968
156STK240.33361516
157CDK70.32702508
158CLK10.31392844
159DYRK1A0.30097236
160CAMK2A0.30091578
161CDK30.29704033
162CSNK1A10.29271390

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.39608941
2RNA polymerase_Homo sapiens_hsa030204.13619946
3Ribosome_Homo sapiens_hsa030104.07549127
4Oxidative phosphorylation_Homo sapiens_hsa001903.44843477
5Parkinsons disease_Homo sapiens_hsa050122.83017639
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.82890743
7Spliceosome_Homo sapiens_hsa030402.46777176
8Notch signaling pathway_Homo sapiens_hsa043302.43139609
9Homologous recombination_Homo sapiens_hsa034402.38839831
10Huntingtons disease_Homo sapiens_hsa050162.32896195
11Protein export_Homo sapiens_hsa030602.32254730
12Nucleotide excision repair_Homo sapiens_hsa034202.25147060
13Basal transcription factors_Homo sapiens_hsa030222.25093079
14DNA replication_Homo sapiens_hsa030302.23275231
15Pyrimidine metabolism_Homo sapiens_hsa002402.20360619
16Mismatch repair_Homo sapiens_hsa034302.18547729
17Fanconi anemia pathway_Homo sapiens_hsa034602.18321492
18Alzheimers disease_Homo sapiens_hsa050102.08003586
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.92809297
20RNA transport_Homo sapiens_hsa030131.90872995
21Fructose and mannose metabolism_Homo sapiens_hsa000511.78982431
22B cell receptor signaling pathway_Homo sapiens_hsa046621.76196029
23Vitamin B6 metabolism_Homo sapiens_hsa007501.60485632
24Base excision repair_Homo sapiens_hsa034101.59978021
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.58006233
26Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.56585184
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.56390925
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.53286456
29Collecting duct acid secretion_Homo sapiens_hsa049661.43809166
30Purine metabolism_Homo sapiens_hsa002301.36033642
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35450165
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.32722603
33Basal cell carcinoma_Homo sapiens_hsa052171.30960771
34RNA degradation_Homo sapiens_hsa030181.30955342
35Phototransduction_Homo sapiens_hsa047441.30779138
36Cell cycle_Homo sapiens_hsa041101.28645236
37Steroid biosynthesis_Homo sapiens_hsa001001.28066913
38Acute myeloid leukemia_Homo sapiens_hsa052211.24392203
39mRNA surveillance pathway_Homo sapiens_hsa030151.09464305
40Epstein-Barr virus infection_Homo sapiens_hsa051691.01469375
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99051467
42SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98997733
43Sphingolipid metabolism_Homo sapiens_hsa006000.98906994
44VEGF signaling pathway_Homo sapiens_hsa043700.98163699
45Ether lipid metabolism_Homo sapiens_hsa005650.97085712
46Non-small cell lung cancer_Homo sapiens_hsa052230.95475312
47Arachidonic acid metabolism_Homo sapiens_hsa005900.93857851
48Cardiac muscle contraction_Homo sapiens_hsa042600.93737988
49Rheumatoid arthritis_Homo sapiens_hsa053230.93478266
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91782899
51Regulation of autophagy_Homo sapiens_hsa041400.86301948
52Graft-versus-host disease_Homo sapiens_hsa053320.85484131
53HTLV-I infection_Homo sapiens_hsa051660.85198534
54Toll-like receptor signaling pathway_Homo sapiens_hsa046200.85048327
55Nicotine addiction_Homo sapiens_hsa050330.84970281
56Linoleic acid metabolism_Homo sapiens_hsa005910.84559937
57Inositol phosphate metabolism_Homo sapiens_hsa005620.84486559
58Bladder cancer_Homo sapiens_hsa052190.84199380
59Non-homologous end-joining_Homo sapiens_hsa034500.84041174
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.83917647
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81485074
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81460574
63Prion diseases_Homo sapiens_hsa050200.79883537
64Serotonergic synapse_Homo sapiens_hsa047260.79346934
65Pentose phosphate pathway_Homo sapiens_hsa000300.78370184
66p53 signaling pathway_Homo sapiens_hsa041150.77510835
67Colorectal cancer_Homo sapiens_hsa052100.76680275
68Endometrial cancer_Homo sapiens_hsa052130.75170053
69Allograft rejection_Homo sapiens_hsa053300.74937093
70Chronic myeloid leukemia_Homo sapiens_hsa052200.74588716
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71148385
72One carbon pool by folate_Homo sapiens_hsa006700.70782942
73Lysine degradation_Homo sapiens_hsa003100.70495592
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69695210
75Vibrio cholerae infection_Homo sapiens_hsa051100.69571529
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67859539
77Synaptic vesicle cycle_Homo sapiens_hsa047210.67833336
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67441652
79Biosynthesis of amino acids_Homo sapiens_hsa012300.67107635
80mTOR signaling pathway_Homo sapiens_hsa041500.66450769
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65045191
82Hepatitis B_Homo sapiens_hsa051610.64415138
83Oocyte meiosis_Homo sapiens_hsa041140.63944358
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62753354
85Wnt signaling pathway_Homo sapiens_hsa043100.62083975
86HIF-1 signaling pathway_Homo sapiens_hsa040660.60927898
87Renal cell carcinoma_Homo sapiens_hsa052110.60198988
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57914829
89Influenza A_Homo sapiens_hsa051640.57672079
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57655622
91Autoimmune thyroid disease_Homo sapiens_hsa053200.57008150
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56090340
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.55850198
94Hepatitis C_Homo sapiens_hsa051600.55850123
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55359330
96Osteoclast differentiation_Homo sapiens_hsa043800.55249595
97Systemic lupus erythematosus_Homo sapiens_hsa053220.54349193
98ErbB signaling pathway_Homo sapiens_hsa040120.54334518
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.54274230
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54095153
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53315018
102Prostate cancer_Homo sapiens_hsa052150.53132471
103Alcoholism_Homo sapiens_hsa050340.52829030
104Thyroid cancer_Homo sapiens_hsa052160.51857617
105Asthma_Homo sapiens_hsa053100.51092660
106Pancreatic cancer_Homo sapiens_hsa052120.49404094
107Shigellosis_Homo sapiens_hsa051310.48874988
108Fatty acid elongation_Homo sapiens_hsa000620.48663129
109Phagosome_Homo sapiens_hsa041450.48195261
110Leishmaniasis_Homo sapiens_hsa051400.47990309
111Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47557770
112Metabolic pathways_Homo sapiens_hsa011000.46845228
113Melanogenesis_Homo sapiens_hsa049160.46655475
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46477358
115Apoptosis_Homo sapiens_hsa042100.45783574
116Taste transduction_Homo sapiens_hsa047420.45336322
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43768889
118Prolactin signaling pathway_Homo sapiens_hsa049170.42956244
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42318473
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.41764667
121Type I diabetes mellitus_Homo sapiens_hsa049400.39839256
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38516811
123MAPK signaling pathway_Homo sapiens_hsa040100.38034746
124Other glycan degradation_Homo sapiens_hsa005110.37078587
125Endocytosis_Homo sapiens_hsa041440.36179497
126Primary immunodeficiency_Homo sapiens_hsa053400.34902396
127Morphine addiction_Homo sapiens_hsa050320.33979502
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.33413729
129Glutamatergic synapse_Homo sapiens_hsa047240.33279869
130Small cell lung cancer_Homo sapiens_hsa052220.32866006
131Folate biosynthesis_Homo sapiens_hsa007900.30919280
132NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29212094
133NF-kappa B signaling pathway_Homo sapiens_hsa040640.26541611
134Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25838643
135Glutathione metabolism_Homo sapiens_hsa004800.25811024
136GABAergic synapse_Homo sapiens_hsa047270.24140127
137Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23517888
138Axon guidance_Homo sapiens_hsa043600.23491850
139Hedgehog signaling pathway_Homo sapiens_hsa043400.23112436
140Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21809096
141Dopaminergic synapse_Homo sapiens_hsa047280.21555761
142Hematopoietic cell lineage_Homo sapiens_hsa046400.21125928
143Long-term depression_Homo sapiens_hsa047300.19406388
144Viral carcinogenesis_Homo sapiens_hsa052030.18810084
145Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.17548799
146Glycerophospholipid metabolism_Homo sapiens_hsa005640.17067324
147Olfactory transduction_Homo sapiens_hsa047400.16885820
148African trypanosomiasis_Homo sapiens_hsa051430.16778068
149Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.16333425
150Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.14834931
151Herpes simplex infection_Homo sapiens_hsa051680.14001402
152Sulfur relay system_Homo sapiens_hsa041220.12474597
153Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.12357177
154Ras signaling pathway_Homo sapiens_hsa040140.11810525
155Arginine and proline metabolism_Homo sapiens_hsa003300.11462818
156Amphetamine addiction_Homo sapiens_hsa050310.09236010

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