PRKX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1activated T cell proliferation (GO:0050798)5.58598569
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.55034479
3negative T cell selection (GO:0043383)4.67552172
4positive regulation by symbiont of host defense response (GO:0052509)4.62567780
5modulation by symbiont of host defense response (GO:0052031)4.62567780
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.62567780
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.62567780
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.62567780
9modulation by symbiont of host immune response (GO:0052553)4.62567780
10response to interleukin-15 (GO:0070672)4.53613036
11negative thymic T cell selection (GO:0045060)4.43750424
12cellular response to interleukin-15 (GO:0071350)4.31900112
13response to peptidoglycan (GO:0032494)4.26581194
14regulation of B cell differentiation (GO:0045577)4.20575567
15positive regulation of gamma-delta T cell activation (GO:0046645)4.17008230
16regulation of isotype switching to IgG isotypes (GO:0048302)4.14410936
17neutrophil activation involved in immune response (GO:0002283)4.07505689
18regulation of translation, ncRNA-mediated (GO:0045974)4.00810099
19negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.00810099
20negative regulation of translation, ncRNA-mediated (GO:0040033)4.00810099
21positive T cell selection (GO:0043368)3.99224357
22negative regulation of T cell mediated immunity (GO:0002710)3.97994727
23positive regulation of interferon-alpha production (GO:0032727)3.87510694
24negative regulation of T-helper cell differentiation (GO:0045623)3.81389839
25negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.81389839
26neutrophil activation (GO:0042119)3.81101700
27granulocyte activation (GO:0036230)3.78804043
28regulation of interferon-alpha production (GO:0032647)3.73133837
29antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.72569531
30antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.72569531
31T cell selection (GO:0045058)3.71778595
32negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.70603945
33type I interferon signaling pathway (GO:0060337)3.70207399
34cellular response to type I interferon (GO:0071357)3.70207399
35response to muramyl dipeptide (GO:0032495)3.69640055
36regulation of interleukin-12 biosynthetic process (GO:0045075)3.69254565
37response to type I interferon (GO:0034340)3.66887608
38regulation of posttranscriptional gene silencing (GO:0060147)3.63331576
39regulation of gene silencing by miRNA (GO:0060964)3.63331576
40regulation of gene silencing by RNA (GO:0060966)3.63331576
41antigen processing and presentation of endogenous antigen (GO:0019883)3.61424765
42histone H3-K4 trimethylation (GO:0080182)3.51555799
43regulation of interferon-beta biosynthetic process (GO:0045357)3.47103797
44thymic T cell selection (GO:0045061)3.37252105
45positive thymic T cell selection (GO:0045059)3.36968335
46positive regulation of B cell differentiation (GO:0045579)3.36125402
47interferon-gamma-mediated signaling pathway (GO:0060333)3.35677001
48positive regulation of DNA recombination (GO:0045911)3.35562647
49monocyte chemotaxis (GO:0002548)3.35412834
50myeloid dendritic cell differentiation (GO:0043011)3.34776234
51mast cell degranulation (GO:0043303)3.32164143
52mast cell activation involved in immune response (GO:0002279)3.32164143
53response to host immune response (GO:0052572)3.30965872
54response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.30965872
55glucocorticoid biosynthetic process (GO:0006704)3.29241550
56myeloid dendritic cell activation (GO:0001773)3.27710961
57immunoglobulin mediated immune response (GO:0016064)3.26854040
58T cell homeostasis (GO:0043029)3.26125658
59pre-miRNA processing (GO:0031054)3.24939327
60cytoplasmic mRNA processing body assembly (GO:0033962)3.22651939
61negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.18963728
62negative regulation of cell killing (GO:0031342)3.18963728
63positive regulation of interferon-beta production (GO:0032728)3.18577121
64positive regulation of granulocyte differentiation (GO:0030854)3.17395874
65negative regulation of lymphocyte mediated immunity (GO:0002707)3.15826383
66negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.15327864
67positive regulation of interleukin-12 production (GO:0032735)3.14667967
68T cell migration (GO:0072678)3.14176008
69negative regulation of adaptive immune response (GO:0002820)3.13743824
70regulation of regulatory T cell differentiation (GO:0045589)3.12219246
71positive regulation of antigen processing and presentation (GO:0002579)3.12131686
72regulation of dendritic cell antigen processing and presentation (GO:0002604)3.10980877
73mast cell activation (GO:0045576)3.10423978
74B cell receptor signaling pathway (GO:0050853)3.08645521
75macrophage activation involved in immune response (GO:0002281)3.08373462
76regulation of chemokine biosynthetic process (GO:0045073)3.07824541
77NIK/NF-kappaB signaling (GO:0038061)3.07816338
78regulation of interleukin-2 biosynthetic process (GO:0045076)3.05747889
79alpha-beta T cell differentiation (GO:0046632)3.03787913
80regulation of isotype switching (GO:0045191)2.99823593
81positive regulation of T cell differentiation in thymus (GO:0033089)2.98843790
82regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.95581875
83alpha-beta T cell activation (GO:0046631)2.94780830
84T cell proliferation (GO:0042098)2.94484995
85response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.94072133
86response to host (GO:0075136)2.94072133
87response to host defenses (GO:0052200)2.94072133
88positive regulation of mRNA catabolic process (GO:0061014)2.90764781
89regulation of alpha-beta T cell proliferation (GO:0046640)2.90540501
90regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.89631464
91regulation of natural killer cell mediated immunity (GO:0002715)2.89631464
92positive regulation of type 2 immune response (GO:0002830)2.89397881
93positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.89350709
94natural killer cell mediated cytotoxicity (GO:0042267)2.88786869
95natural killer cell mediated immunity (GO:0002228)2.88786869
96T cell differentiation (GO:0030217)2.88541857
97lymphocyte homeostasis (GO:0002260)2.88118474
98leukocyte aggregation (GO:0070486)2.88020878
99lipopolysaccharide-mediated signaling pathway (GO:0031663)2.87763241
100regulation of B cell receptor signaling pathway (GO:0050855)2.86839235
101positive regulation of cellular amide metabolic process (GO:0034250)2.83632637
102negative regulation of alpha-beta T cell differentiation (GO:0046639)2.83540691
103defense response to protozoan (GO:0042832)2.83113569
104regulation of gamma-delta T cell activation (GO:0046643)2.82126444
105regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.81178288
106regulation of T-helper 1 cell differentiation (GO:0045625)2.80509480
107positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.79443762
108negative regulation of alpha-beta T cell activation (GO:0046636)2.78897679
109positive regulation of alpha-beta T cell proliferation (GO:0046641)2.78031776
110B cell homeostasis (GO:0001782)2.77279074
111neural tube formation (GO:0001841)2.77261504
112positive regulation of chemokine biosynthetic process (GO:0045080)2.76503971
113myeloid cell activation involved in immune response (GO:0002275)2.75792867
114JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.73238400
115dendritic cell chemotaxis (GO:0002407)2.72643603
116microglial cell activation (GO:0001774)2.71962212
117positive regulation of immunoglobulin mediated immune response (GO:0002891)2.71823281
118positive regulation of B cell mediated immunity (GO:0002714)2.71823281
119interferon-gamma production (GO:0032609)2.70401768
120regulation of T cell tolerance induction (GO:0002664)2.70186454
121cellular response to interferon-beta (GO:0035458)2.68078995
122myeloid leukocyte activation (GO:0002274)2.67264283
123regulation of antigen processing and presentation (GO:0002577)2.66408054
124response to protozoan (GO:0001562)2.65576138
125positive regulation of interleukin-17 production (GO:0032740)2.65425616
126tolerance induction (GO:0002507)2.64852400
127positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.64179901
128substrate-dependent cell migration (GO:0006929)2.64048909
129membrane raft organization (GO:0031579)2.62687916
130regulation of mRNA catabolic process (GO:0061013)2.62524355
131dendritic cell differentiation (GO:0097028)2.61869786
132dendritic cell migration (GO:0036336)2.61678451
133negative regulation of viral genome replication (GO:0045071)2.61075194
134regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.61008987
135positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.61008987
136histone H3-K36 demethylation (GO:0070544)2.60704722
137regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.60251618
138positive regulation of interleukin-2 production (GO:0032743)2.60012763
139positive regulation of heat generation (GO:0031652)2.59604460
140regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.59515756
141negative regulation of interleukin-12 production (GO:0032695)2.59237068
142antigen receptor-mediated signaling pathway (GO:0050851)2.59212859
143positive regulation of immunoglobulin production (GO:0002639)2.58962998
144positive regulation of tolerance induction (GO:0002645)2.58684391
145positive regulation of interleukin-1 beta secretion (GO:0050718)2.58645223
146positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.58511569
147regulation of fever generation (GO:0031620)2.58401874
148macrophage activation (GO:0042116)2.57687614
149respiratory burst (GO:0045730)2.57270150
150cellular response to virus (GO:0098586)2.57133728
151positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.57034967
152response to interferon-beta (GO:0035456)2.56965044
153leukocyte cell-cell adhesion (GO:0007159)2.56899220
154regulation of tolerance induction (GO:0002643)2.56220442
155regulation of alpha-beta T cell activation (GO:0046634)2.56097151
156androgen biosynthetic process (GO:0006702)2.55875001
157Peyers patch development (GO:0048541)2.54932093
158mucosal-associated lymphoid tissue development (GO:0048537)2.54932093
159embryonic hemopoiesis (GO:0035162)2.54906141
160peptidyl-lysine trimethylation (GO:0018023)2.54688428
161regulation of RIG-I signaling pathway (GO:0039535)2.54677937
162positive regulation of B cell activation (GO:0050871)2.53991861
163establishment of endothelial barrier (GO:0061028)2.53813472
164negative regulation of lipid storage (GO:0010888)2.53709447
165regulation of interleukin-12 production (GO:0032655)2.53597828
166regulation of B cell activation (GO:0050864)2.52973094
167regulation of gamma-delta T cell differentiation (GO:0045586)2.51732648
168regulation of mononuclear cell migration (GO:0071675)2.51636158
169germinal center formation (GO:0002467)2.50736768
170T-helper 1 type immune response (GO:0042088)2.49995019
171positive regulation of natural killer cell mediated immunity (GO:0002717)2.49713837
172T cell activation involved in immune response (GO:0002286)2.49138541
173positive regulation of humoral immune response (GO:0002922)2.49076657
174positive regulation of isotype switching (GO:0045830)2.49008775
175positive regulation of macrophage differentiation (GO:0045651)2.48900878
176T cell activation (GO:0042110)2.48384219
177positive regulation of defense response to virus by host (GO:0002230)2.48209783
178negative regulation of nitric oxide biosynthetic process (GO:0045019)2.47295949

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.84749573
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.73467050
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.11413067
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.90013746
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.47312696
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.96961886
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.91708066
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.53056398
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.49362780
10TP63_17297297_ChIP-ChIP_HaCaT_Human3.36677141
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.36281198
12SMAD_19615063_ChIP-ChIP_OVARY_Human3.05250896
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.98357107
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.95108329
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.85053034
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.82708580
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.69603432
18MYC_22102868_ChIP-Seq_BL_Human2.63777375
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.61861509
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.41194907
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.37064068
22RUNX_20019798_ChIP-Seq_JUKART_Human2.34848589
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.28771339
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.20455753
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.04003576
26MYB_26560356_Chip-Seq_TH2_Human2.01575086
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.97534382
28GATA1_22025678_ChIP-Seq_K562_Human1.92118474
29VDR_24787735_ChIP-Seq_THP-1_Human1.87317079
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.76499309
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.72052285
32GATA2_21666600_ChIP-Seq_HMVEC_Human1.66348017
33KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.65269395
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.64043738
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.63042988
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.60131275
37CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.59403780
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.57906964
39PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.55071780
40SPI1_23547873_ChIP-Seq_NB4_Human1.53552539
41SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.45330076
42SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.45330076
43PU_27001747_Chip-Seq_BMDM_Mouse1.43960735
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41382457
45MYB_26560356_Chip-Seq_TH1_Human1.40329385
46MAF_26560356_Chip-Seq_TH1_Human1.39711488
47PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38449526
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38338930
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.36938786
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34397337
51TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31538412
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31538412
53KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.29073337
54KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.29073337
55KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.29073337
56RUNX1_22412390_ChIP-Seq_EML_Mouse1.28957995
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.28939134
58VDR_24763502_ChIP-Seq_THP-1_Human1.27846374
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26930110
60CJUN_26792858_Chip-Seq_BT549_Human1.26273144
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25833641
62AR_21572438_ChIP-Seq_LNCaP_Human1.25100661
63SPI1_23127762_ChIP-Seq_K562_Human1.21200805
64GATA3_27048872_Chip-Seq_THYMUS_Human1.20706336
65CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20506911
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20451836
67MAF_26560356_Chip-Seq_TH2_Human1.19539282
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18838892
69IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17788636
70WT1_19549856_ChIP-ChIP_CCG9911_Human1.16474490
71* EWS_26573619_Chip-Seq_HEK293_Human1.15974097
72TRIM28_21343339_ChIP-Seq_HEK293_Human1.15598200
73SCL_19346495_ChIP-Seq_HPC-7_Human1.15543325
74ZNF274_21170338_ChIP-Seq_K562_Hela1.12745383
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12386220
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12103078
77NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10819192
78SOX2_20726797_ChIP-Seq_SW620_Human1.09501343
79KDM2B_26808549_Chip-Seq_DND41_Human1.08603797
80ESR1_21235772_ChIP-Seq_MCF-7_Human1.08583091
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07485328
82CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06591364
83FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03989917
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03096930
85CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03082143
86GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02159652
87ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02069518
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01040647
89RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.99844353
90JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99050948
91MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98705537
92CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.98378406
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98365927
94SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97455515
95GATA3_26560356_Chip-Seq_TH2_Human0.96287399
96UTX_26944678_Chip-Seq_JUKART_Human0.95485872
97CIITA_25753668_ChIP-Seq_RAJI_Human0.93826173
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.93124261
99THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92926695
100VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92683694
101GATA3_26560356_Chip-Seq_TH1_Human0.92345895
102PRDM14_20953172_ChIP-Seq_ESCs_Human0.91375653
103FOXO3_23340844_ChIP-Seq_DLD1_Human0.90079586
104KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90060538
105RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.89987181
106TCF7_22412390_ChIP-Seq_EML_Mouse0.89556995
107RXR_22108803_ChIP-Seq_LS180_Human0.86553404
108KDM2B_26808549_Chip-Seq_JURKAT_Human0.85836563
109GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85526568
110JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85417583
111* EGR1_19032775_ChIP-ChIP_M12_Human0.83800302
112RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83097185
113E2F4_17652178_ChIP-ChIP_JURKAT_Human0.82664181
114VDR_22108803_ChIP-Seq_LS180_Human0.82618710
115CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.82023431
116PPAR_26484153_Chip-Seq_NCI-H1993_Human0.81708813
117SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.81682391
118BCAT_22108803_ChIP-Seq_LS180_Human0.81370059
119TP53_18474530_ChIP-ChIP_U2OS_Human0.80999013
120SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80748318
121TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.80370630
122NRF2_20460467_ChIP-Seq_MEFs_Mouse0.78273508
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.78273508
124KDM2B_26808549_Chip-Seq_SUP-B15_Human0.78250591
125HIF1A_21447827_ChIP-Seq_MCF-7_Human0.77770971
126BRD4_25478319_ChIP-Seq_HGPS_Human0.77732627
127OCT4_21477851_ChIP-Seq_ESCs_Mouse0.77470440
128KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.77129202
129POU5F1_16153702_ChIP-ChIP_HESCs_Human0.76891324
130CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76421253
131SOX9_24532713_ChIP-Seq_HFSC_Mouse0.76131663
132IRF1_19129219_ChIP-ChIP_H3396_Human0.75552963
133VDR_21846776_ChIP-Seq_THP-1_Human0.75465746
134CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.75386653
135* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.74985747
136TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.74790585
137E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.74098425
138ELK3_25401928_ChIP-Seq_HUVEC_Human0.73923969
139FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.73506769
140VDR_23849224_ChIP-Seq_CD4+_Human0.73341349
141MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.73037036
142TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72955106
143AHR_22903824_ChIP-Seq_MCF-7_Human0.72230320
144ER_23166858_ChIP-Seq_MCF-7_Human0.72094509
145CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.71516086
146TP63_23658742_ChIP-Seq_EP156T_Human0.70240273
147SMRT_27268052_Chip-Seq_Bcells_Human0.69478198
148ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.68529459
149LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.68297326
150GATA2_22383799_ChIP-Seq_G1ME_Mouse0.66509410

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.84635962
2MP0009785_altered_susceptibility_to3.39073893
3MP0008057_abnormal_DNA_replication3.20398497
4MP0008004_abnormal_stomach_pH3.03974846
5MP0006082_CNS_inflammation2.97205437
6MP0003436_decreased_susceptibility_to2.94041683
7MP0005387_immune_system_phenotype2.88816891
8MP0001790_abnormal_immune_system2.88816891
9MP0005671_abnormal_response_to2.86691922
10MP0005000_abnormal_immune_tolerance2.82143424
11MP0003724_increased_susceptibility_to2.81975470
12MP0002148_abnormal_hypersensitivity_rea2.80486905
13MP0000685_abnormal_immune_system2.72467481
14MP0002419_abnormal_innate_immunity2.56753385
15MP0002452_abnormal_antigen_presenting2.50960568
16MP0005025_abnormal_response_to2.46701570
17MP0001800_abnormal_humoral_immune2.45133097
18MP0003303_peritoneal_inflammation2.34240034
19MP0002723_abnormal_immune_serum2.32564264
20MP0004510_myositis2.28956782
21MP0003890_abnormal_embryonic-extraembry2.27834797
22MP0001819_abnormal_immune_cell2.23265172
23MP0002420_abnormal_adaptive_immunity2.20423666
24MP0004947_skin_inflammation2.15445594
25MP0001853_heart_inflammation2.13721191
26MP0003763_abnormal_thymus_physiology2.11179983
27MP0002405_respiratory_system_inflammati1.98635655
28MP0003828_pulmonary_edema1.95923622
29MP0008877_abnormal_DNA_methylation1.88615285
30MP0003448_altered_tumor_morphology1.84062419
31MP0010155_abnormal_intestine_physiology1.83431655
32MP0001533_abnormal_skeleton_physiology1.79960070
33MP0002006_tumorigenesis1.78969706
34MP0002166_altered_tumor_susceptibility1.71289778
35MP0003300_gastrointestinal_ulcer1.70314769
36MP0002277_abnormal_respiratory_mucosa1.68578262
37MP0003191_abnormal_cellular_cholesterol1.65150563
38MP0002396_abnormal_hematopoietic_system1.62803302
39MP0002877_abnormal_melanocyte_morpholog1.58799244
40MP0003045_fibrosis1.57005349
41MP0009333_abnormal_splenocyte_physiolog1.55422051
42MP0000716_abnormal_immune_system1.55197998
43MP0002254_reproductive_system_inflammat1.54400307
44MP0002398_abnormal_bone_marrow1.53292622
45MP0001845_abnormal_inflammatory_respons1.52605192
46MP0010352_gastrointestinal_tract_polyps1.48339231
47MP0000858_altered_metastatic_potential1.46939707
48MP0003787_abnormal_imprinting1.42642429
49MP0002998_abnormal_bone_remodeling1.41770082
50MP0000569_abnormal_digit_pigmentation1.41012766
51MP0005310_abnormal_salivary_gland1.40064704
52MP0005464_abnormal_platelet_physiology1.38564022
53MP0009278_abnormal_bone_marrow1.36880211
54MP0001986_abnormal_taste_sensitivity1.36449631
55MP0005075_abnormal_melanosome_morpholog1.34700923
56MP0001851_eye_inflammation1.32790860
57MP0009764_decreased_sensitivity_to1.31393218
58MP0000372_irregular_coat_pigmentation1.27235584
59MP0002138_abnormal_hepatobiliary_system1.22219516
60MP0001879_abnormal_lymphatic_vessel1.21670035
61MP0005164_abnormal_response_to1.21434618
62MP0000490_abnormal_crypts_of1.21018809
63MP0003453_abnormal_keratinocyte_physiol1.18884981
64MP0000343_altered_response_to1.17521688
65MP0002429_abnormal_blood_cell1.17260017
66MP0004782_abnormal_surfactant_physiolog1.17192535
67MP0004185_abnormal_adipocyte_glucose1.16022142
68MP0005397_hematopoietic_system_phenotyp1.15774407
69MP0001545_abnormal_hematopoietic_system1.15774407
70MP0003091_abnormal_cell_migration1.14496477
71MP0000689_abnormal_spleen_morphology1.13065015
72MP0000470_abnormal_stomach_morphology1.10693624
73MP0002722_abnormal_immune_system1.10256956
74MP0003011_delayed_dark_adaptation1.09819758
75MP0003950_abnormal_plasma_membrane1.08351745
76MP0003566_abnormal_cell_adhesion1.04960448
77MP0002933_joint_inflammation1.04438236
78MP0002332_abnormal_exercise_endurance1.03635087
79MP0008469_abnormal_protein_level1.03340719
80MP0001919_abnormal_reproductive_system1.01612777
81MP0005174_abnormal_tail_pigmentation1.01344850
82MP0001188_hyperpigmentation1.00174797
83MP0004808_abnormal_hematopoietic_stem0.99996433
84MP0001663_abnormal_digestive_system0.99706582
85MP0005390_skeleton_phenotype0.99080713
86MP0001542_abnormal_bone_strength0.98606721
87MP0004858_abnormal_nervous_system0.97957090
88MP0002653_abnormal_ependyma_morphology0.97128011
89MP0000015_abnormal_ear_pigmentation0.96346781
90MP0002163_abnormal_gland_morphology0.96024266
91MP0000703_abnormal_thymus_morphology0.94485906
92MP0001346_abnormal_lacrimal_gland0.94052172
93MP0000465_gastrointestinal_hemorrhage0.92445589
94MP0002009_preneoplasia0.92347727
95MP0003075_altered_response_to0.92082906
96MP0000383_abnormal_hair_follicle0.91147703
97MP0004883_abnormal_blood_vessel0.90988652
98MP0002132_abnormal_respiratory_system0.89315349
99MP0003183_abnormal_peptide_metabolism0.87397530
100MP0003941_abnormal_skin_development0.86287195
101MP0003705_abnormal_hypodermis_morpholog0.85250911
102MP0003866_abnormal_defecation0.84900383
103MP0004381_abnormal_hair_follicle0.84224438
104MP0000767_abnormal_smooth_muscle0.82780664
105MP0001873_stomach_inflammation0.82127319
106MP0002019_abnormal_tumor_incidence0.82046911
107MP0000627_abnormal_mammary_gland0.81893391
108MP0002736_abnormal_nociception_after0.81126917
109MP0005076_abnormal_cell_differentiation0.79527653
110MP0003690_abnormal_glial_cell0.77881709
111MP0001216_abnormal_epidermal_layer0.76882375
112MP0005257_abnormal_intraocular_pressure0.75898225
113MP0004742_abnormal_vestibular_system0.75478330
114MP0001191_abnormal_skin_condition0.71994939
115MP0005166_decreased_susceptibility_to0.71219664
116MP0003567_abnormal_fetal_cardiomyocyte0.71000376
117MP0003795_abnormal_bone_structure0.70575487
118MP0000249_abnormal_blood_vessel0.69174126
119MP0005171_absent_coat_pigmentation0.68957140
120MP0008058_abnormal_DNA_repair0.65737357
121MP0001881_abnormal_mammary_gland0.65360121
122MP0006292_abnormal_olfactory_placode0.65313960
123MP0005334_abnormal_fat_pad0.63116451
124MP0003943_abnormal_hepatobiliary_system0.60325537
125MP0009765_abnormal_xenobiotic_induced0.60051424
126MP0001727_abnormal_embryo_implantation0.59958983
127MP0003121_genomic_imprinting0.59175038
128MP0008007_abnormal_cellular_replicative0.59005851
129MP0003119_abnormal_digestive_system0.55346857
130MP0002088_abnormal_embryonic_growth/wei0.53475961
131MP0001119_abnormal_female_reproductive0.52912007
132MP0000427_abnormal_hair_cycle0.52329460
133MP0005499_abnormal_olfactory_system0.51759529
134MP0005394_taste/olfaction_phenotype0.51759529
135MP0005647_abnormal_sex_gland0.50042835

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.69868204
2Recurrent abscess formation (HP:0002722)5.09526328
3Myositis (HP:0100614)4.78222242
4Orchitis (HP:0100796)4.72333396
5Optic neuritis (HP:0100653)4.65318615
6Retrobulbar optic neuritis (HP:0100654)4.65318615
7Recurrent bacterial skin infections (HP:0005406)4.40986550
8Elevated erythrocyte sedimentation rate (HP:0003565)4.31835815
9Mediastinal lymphadenopathy (HP:0100721)3.97921997
10Abnormality of macrophages (HP:0004311)3.92112658
11Anomalous pulmonary venous return (HP:0010772)3.77583111
12Recurrent fungal infections (HP:0002841)3.64587354
13Prostate neoplasm (HP:0100787)3.52334593
14Large earlobe (HP:0009748)3.51261024
15Increased IgM level (HP:0003496)3.48134381
16Vasculitis (HP:0002633)3.45241805
17Pulmonary infiltrates (HP:0002113)3.36445766
18Panhypogammaglobulinemia (HP:0003139)3.35143147
19Abnormality of the pulmonary veins (HP:0011718)3.24937341
20Autoimmune thrombocytopenia (HP:0001973)3.21010043
21Stomatitis (HP:0010280)3.15455019
22Stenosis of the external auditory canal (HP:0000402)3.04677048
23Chronic otitis media (HP:0000389)3.04415618
24Partial agenesis of the corpus callosum (HP:0001338)3.03703697
25Oligodactyly (hands) (HP:0001180)3.01152308
26Obstructive lung disease (HP:0006536)3.00682204
27Chronic obstructive pulmonary disease (HP:0006510)3.00682204
28Interstitial pulmonary disease (HP:0006530)3.00630578
29Recurrent viral infections (HP:0004429)2.94674530
30Abnormality of T cell number (HP:0011839)2.93936159
31Xerostomia (HP:0000217)2.90996857
32Recurrent skin infections (HP:0001581)2.87884482
33Stomach cancer (HP:0012126)2.86896921
34Recurrent gram-negative bacterial infections (HP:0005420)2.86401320
35Increased IgE level (HP:0003212)2.83121260
36T lymphocytopenia (HP:0005403)2.80753323
37Thick nail (HP:0001805)2.77790037
38Cupped ear (HP:0000378)2.77347627
39Chronic mucocutaneous candidiasis (HP:0002728)2.76187938
40Recurrent cutaneous fungal infections (HP:0011370)2.76187938
41Gingivitis (HP:0000230)2.72678986
42Leukocytosis (HP:0001974)2.68510565
43Abnormality of eosinophils (HP:0001879)2.67379619
44Hematochezia (HP:0002573)2.66703568
45Eosinophilia (HP:0001880)2.65478667
46Keratoconjunctivitis sicca (HP:0001097)2.64620293
47Hypergammaglobulinemia (HP:0010702)2.63602339
48Combined immunodeficiency (HP:0005387)2.63536689
49Diastasis recti (HP:0001540)2.62459298
50Cellulitis (HP:0100658)2.61110624
51Basal ganglia calcification (HP:0002135)2.59726944
52Volvulus (HP:0002580)2.54886991
53Recurrent bronchitis (HP:0002837)2.53607864
54Abnormality of T cell physiology (HP:0011840)2.53404616
55Keratoconjunctivitis (HP:0001096)2.49232088
56Hemoptysis (HP:0002105)2.46627449
57Anhidrosis (HP:0000970)2.46496077
58Oligodontia (HP:0000677)2.45849342
59Thyroiditis (HP:0100646)2.45253500
60Vacuolated lymphocytes (HP:0001922)2.44536648
61Persistence of primary teeth (HP:0006335)2.44032073
62Spontaneous hematomas (HP:0007420)2.43236934
63Meningitis (HP:0001287)2.42339452
64Pustule (HP:0200039)2.41694955
65Agammaglobulinemia (HP:0004432)2.40553009
66Genetic anticipation (HP:0003743)2.37632447
67Cheilitis (HP:0100825)2.34287141
68Osteomyelitis (HP:0002754)2.33499589
69Increased cerebral lipofuscin (HP:0011813)2.33223403
70Arterial thrombosis (HP:0004420)2.28595928
71Glomerulopathy (HP:0100820)2.28449561
72Abnormality of B cell number (HP:0010975)2.24963092
73Systemic lupus erythematosus (HP:0002725)2.24765066
74Verrucae (HP:0200043)2.22825384
75Papilloma (HP:0012740)2.22825384
76IgM deficiency (HP:0002850)2.22221300
77Parakeratosis (HP:0001036)2.20453961
78Abnormality of T cells (HP:0002843)2.18866577
79Abnormality of the pericardium (HP:0001697)2.18705535
80Abnormal pancreas size (HP:0012094)2.16395233
81Skin ulcer (HP:0200042)2.16014704
82Abnormality of the nasal mucosa (HP:0000433)2.15334310
83Increased neuronal autofluorescent lipopigment (HP:0002074)2.14706909
84Periodontitis (HP:0000704)2.14307166
85Abnormality of the prostate (HP:0008775)2.14202086
86Basal cell carcinoma (HP:0002671)2.14164766
87Lymphopenia (HP:0001888)2.13075728
88Submucous cleft hard palate (HP:0000176)2.10952282
89Nasal polyposis (HP:0100582)2.10269715
90Abnormality of cells of the lymphoid lineage (HP:0012140)2.07338375
91Anorexia (HP:0002039)2.07295373
92Recurrent pneumonia (HP:0006532)2.07125282
93Granulocytopenia (HP:0001913)2.06082670
94Osteolytic defects of the phalanges of the hand (HP:0009771)2.04982601
95Osteolytic defects of the hand bones (HP:0009699)2.04982601
96Alveolar cell carcinoma (HP:0006519)2.04312241
97Porencephaly (HP:0002132)2.04294182
98Severe combined immunodeficiency (HP:0004430)2.03571732
99B lymphocytopenia (HP:0010976)2.03365335
100Glucose intolerance (HP:0000833)2.01440100
101Tetraparesis (HP:0002273)1.98857698
102Abnormal delayed hypersensitivity skin test (HP:0002963)1.98113233
103Urticaria (HP:0001025)1.95508226
104Protruding tongue (HP:0010808)1.93437938
105Relative macrocephaly (HP:0004482)1.89072771
106Sepsis (HP:0100806)1.87043635
107Joint swelling (HP:0001386)1.86849785
108Acrocyanosis (HP:0001063)1.86658177
109Encephalitis (HP:0002383)1.85671785
110Segmental peripheral demyelination/remyelination (HP:0003481)1.85551852
111Gangrene (HP:0100758)1.85551313
112Asymmetry of the thorax (HP:0001555)1.84168858
113Abnormality of the columella (HP:0009929)1.82308163
114Reduced subcutaneous adipose tissue (HP:0003758)1.81891089
115Abnormality of the pleura (HP:0002103)1.81575012
116Arthralgia (HP:0002829)1.80944487
117Oligodactyly (HP:0012165)1.80944306
118Abnormality of the alveolar ridges (HP:0006477)1.80498748
119Neoplasm of the tracheobronchial system (HP:0100552)1.80361803
120Autoimmune hemolytic anemia (HP:0001890)1.79915822
121IgG deficiency (HP:0004315)1.76545523
122Clumsiness (HP:0002312)1.75438081
123Abnormality of the nasal septum (HP:0000419)1.75430826
124Recurrent lower respiratory tract infections (HP:0002783)1.75152297
125Increased density of long bones (HP:0006392)1.75116246
126Abnormality of the fingertips (HP:0001211)1.73864129
127Lymphoma (HP:0002665)1.73372234
128Chronic sinusitis (HP:0011109)1.73046479
129Lip pit (HP:0100267)1.72941628
130Hepatosplenomegaly (HP:0001433)1.72279231
131Hypoplasia of the thymus (HP:0000778)1.70126466
132Curly hair (HP:0002212)1.69857333
133Abnormal hair whorl (HP:0010721)1.69048962
134Truncal obesity (HP:0001956)1.68750966
135Hypoplastic nipples (HP:0002557)1.68087419
136IgA deficiency (HP:0002720)1.65636888
137Thrombocytosis (HP:0001894)1.65220933
138Ureteral duplication (HP:0000073)1.63035234
139Split foot (HP:0001839)1.61581177
140Skull defect (HP:0001362)1.60726422
141Colon cancer (HP:0003003)1.60028322
142Amaurosis fugax (HP:0100576)1.59686322
143Progressive inability to walk (HP:0002505)1.58605070
144Inflammation of the large intestine (HP:0002037)1.58059302
145Acute myeloid leukemia (HP:0004808)1.57709468
146Widely spaced teeth (HP:0000687)1.55850779
147Clubbing of toes (HP:0100760)1.55850007
148Labial hypoplasia (HP:0000066)1.54815658

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.16325943
2PRPF4B3.60927999
3TXK3.24361208
4EPHA33.07649073
5TYK23.04821698
6TBK12.90846661
7IRAK42.71492951
8FES2.59613497
9IKBKE2.55932649
10JAK32.49983745
11MST42.49778747
12MAP4K12.43177014
13IKBKB2.39262876
14EPHB12.34336364
15PIM22.29093683
16JAK12.19914429
17FGFR42.08412509
18FGFR32.03110389
19RIPK41.98685656
20IRAK31.97502908
21TGFBR21.95387212
22WNK31.87731670
23SIK31.85102235
24NLK1.78601117
25BLK1.73812778
26CHUK1.72378931
27FRK1.64318286
28STK101.54796742
29NEK91.48716820
30IRAK11.48141064
31CDK41.39728176
32GRK71.38893163
33PASK1.36926203
34KIT1.35679848
35CSK1.35348333
36ITK1.31268917
37TNIK1.30712067
38BMPR21.29848053
39CASK1.26699362
40BMPR1B1.24793771
41ACVR1B1.24515365
42ZAP701.20831990
43HCK1.19114255
44MKNK21.17112486
45MKNK11.12445478
46LCK1.10391413
47PBK1.09910248
48YES11.09446586
49NUAK11.09090268
50SYK1.09033123
51TEC1.08350553
52MAPKAPK31.08144769
53STK241.05804026
54CAMK1D1.05563818
55MARK31.04773027
56TGFBR11.03702953
57BTK1.03229419
58PIM11.02708904
59MATK0.97781912
60TRPM70.96679014
61ERN10.96341385
62BRD40.93937653
63TYRO30.93331503
64TIE10.86862817
65MST1R0.86222366
66CDK120.85741904
67MAP3K30.83645458
68ERBB30.83225615
69HIPK20.82689421
70TAOK20.81625276
71MELK0.79559087
72STK110.79521831
73CAMK1G0.79195662
74MAPK70.77290675
75JAK20.76666375
76EPHA20.74202401
77CAMK40.69155296
78LYN0.68763741
79ADRBK20.66549773
80MAPKAPK20.66179381
81ABL10.66109893
82MAP3K130.65350361
83GRK60.64103728
84MAP3K50.63594884
85PRKCQ0.63541805
86EIF2AK20.62227455
87SGK2230.62088163
88SGK4940.62088163
89OXSR10.61957078
90MAP3K120.61119886
91CSF1R0.60298850
92MAP3K10.57427976
93TAF10.56573633
94FGR0.54539731
95ZAK0.53552831
96TNK20.52978269
97CHEK20.51271921
98MAP3K70.49555294
99NEK20.49037385
100ATR0.48781026
101SIK20.48653817
102PRKCD0.48280236
103STK40.47442483
104TAOK30.46858845
105FGFR20.46371293
106INSRR0.46088435
107RPS6KA60.45879497
108SGK20.45680981
109PDK10.45563750
110EEF2K0.45352910
111EGFR0.44967167
112PDGFRB0.44459545
113DYRK1B0.44422736
114EPHB20.43357644
115PRKCH0.43011021
116RPS6KA50.42393226
117STK30.41764237
118CLK10.41705781
119IRAK20.40780886
120LRRK20.40127731
121RPS6KA40.39672614
122TLK10.39306109
123MARK20.39008502
124MAP3K100.38946442
125MAPK30.38830115
126MAP2K20.38642047
127SGK30.38455974
128RPS6KA20.38423826
129MAP2K30.38356248
130BMX0.37572730
131BCR0.36608766
132DYRK30.36488397
133CDK60.34635497
134TESK10.34239251
135NME20.34212970
136RPS6KL10.32906931
137RPS6KC10.32906931
138CDK90.32522015
139DYRK20.32401151
140DMPK0.31789302

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053322.92018548
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.51668288
3Leishmaniasis_Homo sapiens_hsa051402.48858076
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.31523564
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.22117273
6Allograft rejection_Homo sapiens_hsa053302.16707498
7Measles_Homo sapiens_hsa051622.16334015
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.05732693
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.04184680
10Osteoclast differentiation_Homo sapiens_hsa043802.00502618
11NOD-like receptor signaling pathway_Homo sapiens_hsa046211.99215824
12TNF signaling pathway_Homo sapiens_hsa046681.87415563
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.81929037
14Pertussis_Homo sapiens_hsa051331.79041882
15Malaria_Homo sapiens_hsa051441.75845689
16Toxoplasmosis_Homo sapiens_hsa051451.75328105
17Rheumatoid arthritis_Homo sapiens_hsa053231.71871306
18Influenza A_Homo sapiens_hsa051641.71198112
19Legionellosis_Homo sapiens_hsa051341.68377614
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.60832683
21Autoimmune thyroid disease_Homo sapiens_hsa053201.60814344
22Primary immunodeficiency_Homo sapiens_hsa053401.60456243
23Viral myocarditis_Homo sapiens_hsa054161.57851820
24Tuberculosis_Homo sapiens_hsa051521.57095253
25Hematopoietic cell lineage_Homo sapiens_hsa046401.56124304
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.55148579
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.51336726
28Apoptosis_Homo sapiens_hsa042101.49464880
29Salmonella infection_Homo sapiens_hsa051321.49377005
30B cell receptor signaling pathway_Homo sapiens_hsa046621.46873006
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.44371236
32T cell receptor signaling pathway_Homo sapiens_hsa046601.42637126
33Herpes simplex infection_Homo sapiens_hsa051681.42255431
34Antigen processing and presentation_Homo sapiens_hsa046121.36827159
35Chemokine signaling pathway_Homo sapiens_hsa040621.35338459
36Hepatitis B_Homo sapiens_hsa051611.32214548
37African trypanosomiasis_Homo sapiens_hsa051431.31331346
38Shigellosis_Homo sapiens_hsa051311.30723454
39Hepatitis C_Homo sapiens_hsa051601.26307286
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26033631
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.24907234
42Asthma_Homo sapiens_hsa053101.19567352
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.18926204
44Type I diabetes mellitus_Homo sapiens_hsa049401.17751929
45RNA degradation_Homo sapiens_hsa030181.13663121
46Ovarian steroidogenesis_Homo sapiens_hsa049131.11970895
47Phagosome_Homo sapiens_hsa041451.11735214
48Steroid biosynthesis_Homo sapiens_hsa001001.11191666
49Staphylococcus aureus infection_Homo sapiens_hsa051501.11095935
50Prolactin signaling pathway_Homo sapiens_hsa049171.09698165
51Leukocyte transendothelial migration_Homo sapiens_hsa046701.09302605
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08677323
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05449201
54Acute myeloid leukemia_Homo sapiens_hsa052211.01478960
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99436286
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98956303
57Non-homologous end-joining_Homo sapiens_hsa034500.94176379
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93525896
59Small cell lung cancer_Homo sapiens_hsa052220.92319352
60Chronic myeloid leukemia_Homo sapiens_hsa052200.92258975
61Pancreatic cancer_Homo sapiens_hsa052120.91717776
62Lysosome_Homo sapiens_hsa041420.91533209
63Choline metabolism in cancer_Homo sapiens_hsa052310.89285286
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85609868
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84284852
66Basal transcription factors_Homo sapiens_hsa030220.84020639
67Amoebiasis_Homo sapiens_hsa051460.82655404
68mRNA surveillance pathway_Homo sapiens_hsa030150.81088616
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.80214566
70Spliceosome_Homo sapiens_hsa030400.79857704
71Epstein-Barr virus infection_Homo sapiens_hsa051690.78913836
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77192661
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76532015
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75382405
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.74911519
76HTLV-I infection_Homo sapiens_hsa051660.72693401
77Phototransduction_Homo sapiens_hsa047440.71481798
78Adherens junction_Homo sapiens_hsa045200.71319968
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69909349
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69737380
81FoxO signaling pathway_Homo sapiens_hsa040680.66390716
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.65851626
83Platelet activation_Homo sapiens_hsa046110.64336420
84MicroRNAs in cancer_Homo sapiens_hsa052060.64143044
85Proteoglycans in cancer_Homo sapiens_hsa052050.63495853
86Inositol phosphate metabolism_Homo sapiens_hsa005620.63404356
87Lysine degradation_Homo sapiens_hsa003100.63306769
88Prostate cancer_Homo sapiens_hsa052150.63238108
89Ether lipid metabolism_Homo sapiens_hsa005650.61144951
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60535305
91Fanconi anemia pathway_Homo sapiens_hsa034600.59865160
92VEGF signaling pathway_Homo sapiens_hsa043700.58676317
93Colorectal cancer_Homo sapiens_hsa052100.58350933
94Vitamin digestion and absorption_Homo sapiens_hsa049770.57760475
95Sphingolipid metabolism_Homo sapiens_hsa006000.56565117
96Other glycan degradation_Homo sapiens_hsa005110.55939008
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54716605
98Viral carcinogenesis_Homo sapiens_hsa052030.54580418
99Thyroid cancer_Homo sapiens_hsa052160.54377150
100Notch signaling pathway_Homo sapiens_hsa043300.53810175
101MAPK signaling pathway_Homo sapiens_hsa040100.53495943
102Focal adhesion_Homo sapiens_hsa045100.52882083
103Renal cell carcinoma_Homo sapiens_hsa052110.51818741
104Endocytosis_Homo sapiens_hsa041440.49751851
105Endometrial cancer_Homo sapiens_hsa052130.49694361
106Pathways in cancer_Homo sapiens_hsa052000.48779443
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46243145
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46106876
109p53 signaling pathway_Homo sapiens_hsa041150.45680154
110Melanoma_Homo sapiens_hsa052180.45070090
111Homologous recombination_Homo sapiens_hsa034400.44454869
112Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43746012
113RNA transport_Homo sapiens_hsa030130.43326972
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43288080
115Ras signaling pathway_Homo sapiens_hsa040140.43192127
116Mineral absorption_Homo sapiens_hsa049780.43150446
117Linoleic acid metabolism_Homo sapiens_hsa005910.42928254
118mTOR signaling pathway_Homo sapiens_hsa041500.42625105
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42018408
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.41918327
121HIF-1 signaling pathway_Homo sapiens_hsa040660.41181638
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.40967353
123Rap1 signaling pathway_Homo sapiens_hsa040150.39574691
124Dorso-ventral axis formation_Homo sapiens_hsa043200.38834553
125Type II diabetes mellitus_Homo sapiens_hsa049300.38028189
126PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37916682
127ErbB signaling pathway_Homo sapiens_hsa040120.37909423
128Olfactory transduction_Homo sapiens_hsa047400.36779194
129Non-small cell lung cancer_Homo sapiens_hsa052230.32243130
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31853195
131Insulin resistance_Homo sapiens_hsa049310.29272223
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29068910

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