PRKXP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1activated T cell proliferation (GO:0050798)5.17674238
2negative thymic T cell selection (GO:0045060)4.64954507
3negative regulation of cAMP-mediated signaling (GO:0043951)4.64464808
4negative T cell selection (GO:0043383)4.47691133
5interferon-gamma production (GO:0032609)4.39043589
6positive regulation of gamma-delta T cell activation (GO:0046645)3.99075584
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.82368692
8negative regulation of T cell mediated immunity (GO:0002710)3.75509036
9histone mRNA catabolic process (GO:0071044)3.75123034
10histone H3-K4 trimethylation (GO:0080182)3.62865558
11dopamine biosynthetic process (GO:0042416)3.61974437
12negative regulation of cell killing (GO:0031342)3.46962548
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.46962548
14regulation of cilium movement (GO:0003352)3.40596518
15positive regulation of protein homooligomerization (GO:0032464)3.33994580
16regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.30270328
17positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.30270328
18indolalkylamine metabolic process (GO:0006586)3.28127677
19mRNA splice site selection (GO:0006376)3.26406178
20T cell selection (GO:0045058)3.24854158
21regulation of nuclear cell cycle DNA replication (GO:0033262)3.20537835
22regulation of MHC class I biosynthetic process (GO:0045343)3.20462559
23tolerance induction (GO:0002507)3.19929184
24positive regulation of CREB transcription factor activity (GO:0032793)3.18468599
25positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.18021936
26mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.18021936
27poly(A)+ mRNA export from nucleus (GO:0016973)3.17707607
28serotonin metabolic process (GO:0042428)3.16732052
29mitochondrion transport along microtubule (GO:0047497)3.16228065
30establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.16228065
31forebrain neuron differentiation (GO:0021879)3.15598764
32retinal rod cell development (GO:0046548)3.14675415
33positive T cell selection (GO:0043368)3.14604752
34regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.13231305
35positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.13231305
36thymic T cell selection (GO:0045061)3.09076074
37alkaloid metabolic process (GO:0009820)3.08304001
38establishment of mitochondrion localization (GO:0051654)3.07695695
39regulation of gamma-delta T cell differentiation (GO:0045586)3.07664951
40regulation of B cell receptor signaling pathway (GO:0050855)3.04511280
41negative regulation of mast cell activation (GO:0033004)3.03488277
42positive regulation of granulocyte differentiation (GO:0030854)3.02651053
43negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.01476564
44regulation of gamma-delta T cell activation (GO:0046643)2.97954013
45RNA destabilization (GO:0050779)2.94200812
46detection of light stimulus involved in visual perception (GO:0050908)2.91214999
47detection of light stimulus involved in sensory perception (GO:0050962)2.91214999
48negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.90444221
49negative regulation of translation, ncRNA-mediated (GO:0040033)2.90444221
50regulation of translation, ncRNA-mediated (GO:0045974)2.90444221
51RNA localization (GO:0006403)2.90087293
52regulation of alpha-beta T cell proliferation (GO:0046640)2.88374776
53monoubiquitinated protein deubiquitination (GO:0035520)2.87035706
54cilium or flagellum-dependent cell motility (GO:0001539)2.86881727
55negative regulation of telomere maintenance (GO:0032205)2.85705214
56behavioral response to nicotine (GO:0035095)2.85272958
57positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.84840195
58leukocyte aggregation (GO:0070486)2.84138544
59primary amino compound metabolic process (GO:1901160)2.83305059
60negative regulation of execution phase of apoptosis (GO:1900118)2.83158780
61histone deubiquitination (GO:0016578)2.81666702
62positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.77936572
63negative regulation of adaptive immune response (GO:0002820)2.77433988
64regulation of telomere maintenance (GO:0032204)2.75858962
65olfactory bulb development (GO:0021772)2.75357016
66negative regulation of lymphocyte mediated immunity (GO:0002707)2.74257933
67positive regulation of mRNA catabolic process (GO:0061014)2.73861452
68Peyers patch development (GO:0048541)2.73646232
69mucosal-associated lymphoid tissue development (GO:0048537)2.73646232
70central nervous system projection neuron axonogenesis (GO:0021952)2.67926070
71response to interleukin-15 (GO:0070672)2.67384006
72nonmotile primary cilium assembly (GO:0035058)2.67327657
73positive thymic T cell selection (GO:0045059)2.64929659
74pyrimidine nucleobase catabolic process (GO:0006208)2.62329879
75cellular response to interleukin-15 (GO:0071350)2.60305427
76natural killer cell differentiation (GO:0001779)2.58436876
77adaptation of signaling pathway (GO:0023058)2.57831286
78T cell migration (GO:0072678)2.57392543
79protein targeting to Golgi (GO:0000042)2.56478406
80establishment of protein localization to Golgi (GO:0072600)2.55944355
81positive regulation of alpha-beta T cell proliferation (GO:0046641)2.55128653
82negative regulation of transcription regulatory region DNA binding (GO:2000678)2.54482496
83protein polyglutamylation (GO:0018095)2.53728197
84embryonic hemopoiesis (GO:0035162)2.52931459
85histone H3-K9 methylation (GO:0051567)2.52837258
86peptidyl-lysine trimethylation (GO:0018023)2.50735656
87rRNA catabolic process (GO:0016075)2.48713915
88histone H3-K9 modification (GO:0061647)2.48005087
89DNA deamination (GO:0045006)2.46946015
90regulation of T-helper 1 type immune response (GO:0002825)2.46785938
91negative regulation of alpha-beta T cell activation (GO:0046636)2.45017477
92mitochondrion distribution (GO:0048311)2.44683148
93regulation of isotype switching to IgG isotypes (GO:0048302)2.44681093
94auditory receptor cell differentiation (GO:0042491)2.43950082
95phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.43652196
96neuron cell-cell adhesion (GO:0007158)2.41454786
97negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.40124467
98regulation of mRNA catabolic process (GO:0061013)2.39387426
99regulation of action potential (GO:0098900)2.39000553
100negative regulation of systemic arterial blood pressure (GO:0003085)2.36964309

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.04347479
2ZNF274_21170338_ChIP-Seq_K562_Hela3.99692408
3NOTCH1_21737748_ChIP-Seq_TLL_Human3.71451742
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.13467330
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.08987298
6VDR_22108803_ChIP-Seq_LS180_Human2.72225035
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.53903553
8EZH2_22144423_ChIP-Seq_EOC_Human2.53185176
9IGF1R_20145208_ChIP-Seq_DFB_Human2.16957934
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.02265337
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.01440399
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.95861968
13CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91620056
14RUNX_20019798_ChIP-Seq_JUKART_Human1.84455551
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.83394649
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.75159250
17CIITA_25753668_ChIP-Seq_RAJI_Human1.73495462
18ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71730939
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69707881
20SCL_19346495_ChIP-Seq_HPC-7_Human1.63288794
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.62578756
22TAF15_26573619_Chip-Seq_HEK293_Human1.61500529
23GBX2_23144817_ChIP-Seq_PC3_Human1.59148058
24FUS_26573619_Chip-Seq_HEK293_Human1.58142403
25GATA3_26560356_Chip-Seq_TH2_Human1.53667651
26VDR_23849224_ChIP-Seq_CD4+_Human1.53571169
27VDR_24787735_ChIP-Seq_THP-1_Human1.52704958
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50821595
29TP63_19390658_ChIP-ChIP_HaCaT_Human1.50295238
30STAT3_23295773_ChIP-Seq_U87_Human1.47676198
31MYB_26560356_Chip-Seq_TH2_Human1.47670590
32BCAT_22108803_ChIP-Seq_LS180_Human1.46872963
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46708376
34TP53_22573176_ChIP-Seq_HFKS_Human1.45691776
35EWS_26573619_Chip-Seq_HEK293_Human1.44393475
36ER_23166858_ChIP-Seq_MCF-7_Human1.42224114
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41798761
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.41766759
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.41309418
40WDR5_24793694_ChIP-Seq_LNCAP_Human1.39974758
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.39699451
42MYB_26560356_Chip-Seq_TH1_Human1.37275163
43GATA3_27048872_Chip-Seq_THYMUS_Human1.34548816
44AR_21572438_ChIP-Seq_LNCaP_Human1.31788556
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31552820
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.31097091
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.31035790
48IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30509725
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.30056373
50PRDM14_20953172_ChIP-Seq_ESCs_Human1.25264307
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.23449823
52RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.21729627
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20481213
54TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20481213
55REST_21632747_ChIP-Seq_MESCs_Mouse1.17669299
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17480938
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17298777
58GATA3_26560356_Chip-Seq_TH1_Human1.16152677
59TCF4_23295773_ChIP-Seq_U87_Human1.16094193
60REST_18959480_ChIP-ChIP_MESCs_Mouse1.15645517
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15323891
62GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14999657
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13940795
64P300_19829295_ChIP-Seq_ESCs_Human1.13719504
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13560101
66FLI1_21867929_ChIP-Seq_TH2_Mouse1.12134035
67FOXP3_21729870_ChIP-Seq_TREG_Human1.07726577
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07569601
69DROSHA_22980978_ChIP-Seq_HELA_Human1.05257482
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04738847
71TCF4_22108803_ChIP-Seq_LS180_Human1.04413257
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04271979
73CBP_20019798_ChIP-Seq_JUKART_Human1.04271979
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02687586
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01882607
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00290392
77MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00262128
78P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99701115
79PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99335447
80SMAD4_21799915_ChIP-Seq_A2780_Human0.99029312
81SMAD_19615063_ChIP-ChIP_OVARY_Human0.98441060
82NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98067546
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97848875
84NCOR_22424771_ChIP-Seq_293T_Human0.97530011
85RUNX2_22187159_ChIP-Seq_PCA_Human0.97064585
86RXR_22108803_ChIP-Seq_LS180_Human0.95791574
87HOXB7_26014856_ChIP-Seq_BT474_Human0.95257434
88CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94682799
89NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93660064
90FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93578458
91OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93039397
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92572994
93ELK4_26923725_Chip-Seq_MESODERM_Mouse0.92521878
94YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91599749
95ELK1_19687146_ChIP-ChIP_HELA_Human0.91033099
96RBPJ_22232070_ChIP-Seq_NCS_Mouse0.90580865
97MAF_26560356_Chip-Seq_TH2_Human0.90470387
98TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.88753296
99UTX_26944678_Chip-Seq_JUKART_Human0.88094024
100IRF8_21731497_ChIP-ChIP_J774_Mouse0.88011988

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.77754358
2MP0005360_urolithiasis3.07007502
3MP0005075_abnormal_melanosome_morpholog2.64726487
4MP0008877_abnormal_DNA_methylation2.63105168
5MP0003763_abnormal_thymus_physiology2.58009305
6MP0005671_abnormal_response_to2.54278193
7MP0004885_abnormal_endolymph2.39045481
8MP0004381_abnormal_hair_follicle2.37847559
9MP0001968_abnormal_touch/_nociception2.27240472
10MP0005423_abnormal_somatic_nervous2.23694129
11MP0001986_abnormal_taste_sensitivity2.22916646
12MP0003880_abnormal_central_pattern2.11159303
13MP0000015_abnormal_ear_pigmentation2.05391831
14MP0001800_abnormal_humoral_immune2.01333147
15MP0008057_abnormal_DNA_replication1.96076152
16MP0000372_irregular_coat_pigmentation1.88323273
17MP0002102_abnormal_ear_morphology1.82813602
18MP0005310_abnormal_salivary_gland1.81825398
19MP0003646_muscle_fatigue1.69487582
20MP0009046_muscle_twitch1.68721433
21MP0002638_abnormal_pupillary_reflex1.65742604
22MP0002876_abnormal_thyroid_physiology1.65708302
23MP0002095_abnormal_skin_pigmentation1.62823641
24MP0006292_abnormal_olfactory_placode1.62244287
25MP0003787_abnormal_imprinting1.56312498
26MP0004142_abnormal_muscle_tone1.55522262
27MP0005551_abnormal_eye_electrophysiolog1.53705092
28MP0001790_abnormal_immune_system1.52039871
29MP0005387_immune_system_phenotype1.52039871
30MP0001835_abnormal_antigen_presentation1.50885549
31MP0004742_abnormal_vestibular_system1.49862305
32MP0002822_catalepsy1.48638674
33MP0000778_abnormal_nervous_system1.47423866
34MP0002723_abnormal_immune_serum1.43358025
35MP0004043_abnormal_pH_regulation1.37575621
36MP0002736_abnormal_nociception_after1.37109224
37MP0002420_abnormal_adaptive_immunity1.34483551
38MP0008961_abnormal_basal_metabolism1.34008814
39MP0000631_abnormal_neuroendocrine_gland1.33387221
40MP0001819_abnormal_immune_cell1.32239524
41MP0006276_abnormal_autonomic_nervous1.30097299
42MP0003724_increased_susceptibility_to1.29341168
43MP0009745_abnormal_behavioral_response1.26896089
44MP0003172_abnormal_lysosome_physiology1.26179758
45MP0003136_yellow_coat_color1.25273459
46MP0002398_abnormal_bone_marrow1.25241468
47MP0002452_abnormal_antigen_presenting1.25091659
48MP0005000_abnormal_immune_tolerance1.24688977
49MP0002064_seizures1.22716637
50MP0000703_abnormal_thymus_morphology1.21897685
51MP0000685_abnormal_immune_system1.21142351
52MP0009278_abnormal_bone_marrow1.15153533
53MP0000689_abnormal_spleen_morphology1.14163585
54MP0002405_respiratory_system_inflammati1.13779220
55MP0001486_abnormal_startle_reflex1.09871178
56MP0000716_abnormal_immune_system1.09070472
57MP0000427_abnormal_hair_cycle1.07428082
58MP0008995_early_reproductive_senescence1.06354357
59MP0008058_abnormal_DNA_repair1.06055119
60MP0001984_abnormal_olfaction1.05942052
61MP0002751_abnormal_autonomic_nervous1.05747232
62MP0000371_diluted_coat_color1.05480657
63MP0005386_behavior/neurological_phenoty1.03657251
64MP0004924_abnormal_behavior1.03657251
65MP0002138_abnormal_hepatobiliary_system1.02848816
66MP0002928_abnormal_bile_duct1.01883052
67MP0002063_abnormal_learning/memory/cond1.01683560
68MP0003635_abnormal_synaptic_transmissio1.01544892
69MP0003436_decreased_susceptibility_to1.01049045
70MP0002067_abnormal_sensory_capabilities0.99103532
71MP0002272_abnormal_nervous_system0.99055469
72MP0001905_abnormal_dopamine_level0.96549213
73MP0002234_abnormal_pharynx_morphology0.95857056
74MP0002557_abnormal_social/conspecific_i0.94936284
75MP0006082_CNS_inflammation0.94563872
76MP0003866_abnormal_defecation0.93632218
77MP0001529_abnormal_vocalization0.93304469
78MP0002722_abnormal_immune_system0.92239952
79MP0005253_abnormal_eye_physiology0.91172171
80MP0005174_abnormal_tail_pigmentation0.90949785
81MP0002572_abnormal_emotion/affect_behav0.89184723
82MP0005645_abnormal_hypothalamus_physiol0.87269716
83MP0003938_abnormal_ear_development0.85093708
84MP0003121_genomic_imprinting0.84685575
85MP0000613_abnormal_salivary_gland0.83830984
86MP0002163_abnormal_gland_morphology0.80835159
87MP0005367_renal/urinary_system_phenotyp0.80820567
88MP0000516_abnormal_urinary_system0.80820567
89MP0005025_abnormal_response_to0.76882877
90MP0001348_abnormal_lacrimal_gland0.76302344
91MP0000538_abnormal_urinary_bladder0.76199442
92MP0002419_abnormal_innate_immunity0.75891074
93MP0005499_abnormal_olfactory_system0.74400273
94MP0005394_taste/olfaction_phenotype0.74400273
95MP0003698_abnormal_male_reproductive0.73020284
96MP0002429_abnormal_blood_cell0.70971702
97MP0008789_abnormal_olfactory_epithelium0.70611287
98MP0004811_abnormal_neuron_physiology0.70257518
99MP0001501_abnormal_sleep_pattern0.70066978
100MP0001502_abnormal_circadian_rhythm0.70024394

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the lower motor neuron (HP:0002366)4.04073260
2Medial flaring of the eyebrow (HP:0010747)3.89461186
3Congenital stationary night blindness (HP:0007642)3.89360048
4Hypothermia (HP:0002045)3.50388375
5Abnormality of the labia minora (HP:0012880)3.46115900
6Stomatitis (HP:0010280)3.45021472
7Amyotrophic lateral sclerosis (HP:0007354)3.31162003
8Type II lissencephaly (HP:0007260)2.96476052
9Panhypogammaglobulinemia (HP:0003139)2.96035325
10Abnormal delayed hypersensitivity skin test (HP:0002963)2.94234542
11Limb dystonia (HP:0002451)2.93255364
12Generalized hypopigmentation of hair (HP:0011358)2.84650849
13Lissencephaly (HP:0001339)2.81670701
14Fair hair (HP:0002286)2.80306708
15Hyperventilation (HP:0002883)2.78201039
16Renal cortical cysts (HP:0000803)2.73191231
17Optic neuritis (HP:0100653)2.64717285
18Retrobulbar optic neuritis (HP:0100654)2.64717285
19Protruding tongue (HP:0010808)2.63154807
20Limb hypertonia (HP:0002509)2.60230580
21Pachygyria (HP:0001302)2.60039481
22Gaze-evoked nystagmus (HP:0000640)2.58561167
23Abnormal pupillary function (HP:0007686)2.55352547
24Volvulus (HP:0002580)2.50670102
25Abnormality of the renal cortex (HP:0011035)2.50560480
26Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.49639731
27Gait imbalance (HP:0002141)2.44163879
28Nephrogenic diabetes insipidus (HP:0009806)2.41255358
29Congenital primary aphakia (HP:0007707)2.37299781
30Abnormal hair whorl (HP:0010721)2.30931738
31Recurrent cutaneous fungal infections (HP:0011370)2.29530950
32Chronic mucocutaneous candidiasis (HP:0002728)2.29530950
33Recurrent fungal infections (HP:0002841)2.29441260
34Decreased central vision (HP:0007663)2.29002331
35Myositis (HP:0100614)2.27640876
36Cerebellar dysplasia (HP:0007033)2.25949950
37IgG deficiency (HP:0004315)2.24340755
38Impaired proprioception (HP:0010831)2.22690110
39Progressive inability to walk (HP:0002505)2.21342506
40Focal motor seizures (HP:0011153)2.21097295
41Oligodactyly (hands) (HP:0001180)2.19352894
42Retinal dysplasia (HP:0007973)2.18591640
43Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.17934056
44Short 1st metacarpal (HP:0010034)2.17934056
45Nephronophthisis (HP:0000090)2.14651298
46Pancreatic cysts (HP:0001737)2.12691024
47True hermaphroditism (HP:0010459)2.12130249
48Orchitis (HP:0100796)2.06806792
49Hypoplastic iliac wings (HP:0002866)2.04588656
50Abnormality of T cells (HP:0002843)2.04465687
51Pustule (HP:0200039)2.03958482
52Upper motor neuron abnormality (HP:0002127)2.03192728
53Abnormality of the renal medulla (HP:0100957)2.02921909
54Abnormality of the pubic bones (HP:0003172)2.02807016
55Absent speech (HP:0001344)2.02401294
56Broad-based gait (HP:0002136)1.99439104
57Pancreatic fibrosis (HP:0100732)1.97237633
58Abnormality of T cell physiology (HP:0011840)1.97179601
59Abnormality of the metopic suture (HP:0005556)1.97032347
60Poor coordination (HP:0002370)1.94983539
61Tented upper lip vermilion (HP:0010804)1.93586317
62Abnormality of lateral ventricle (HP:0030047)1.92740816
63Inability to walk (HP:0002540)1.91358599
64Rib fusion (HP:0000902)1.90788422
65Clumsiness (HP:0002312)1.90412521
66Abnormal rod and cone electroretinograms (HP:0008323)1.88562520
67Gastrointestinal infarctions (HP:0005244)1.88356823
68Stomach cancer (HP:0012126)1.86000758
69Shawl scrotum (HP:0000049)1.85093263
70Prominent nasal bridge (HP:0000426)1.82881443
71Abnormality of the 1st metacarpal (HP:0010009)1.82523673
72Abnormality of T cell number (HP:0011839)1.81853650
73Abnormality of the anterior horn cell (HP:0006802)1.81088942
74Degeneration of anterior horn cells (HP:0002398)1.81088942
75Vaginal atresia (HP:0000148)1.80370459
76Widely spaced teeth (HP:0000687)1.79564166
77Abnormality of macular pigmentation (HP:0008002)1.78502336
78Hip dysplasia (HP:0001385)1.77248145
79Genital tract atresia (HP:0001827)1.77071551
80Optic nerve hypoplasia (HP:0000609)1.76166423
81Severe combined immunodeficiency (HP:0004430)1.75959253
82Ocular albinism (HP:0001107)1.75589299
83Truncal obesity (HP:0001956)1.75150743
84Abnormality of eosinophils (HP:0001879)1.74391342
85Severe muscular hypotonia (HP:0006829)1.73786932
86Postaxial hand polydactyly (HP:0001162)1.73621932
87Iris hypopigmentation (HP:0007730)1.72552951
88Keratoconjunctivitis (HP:0001096)1.72516411
89Excessive salivation (HP:0003781)1.72281558
90Bony spicule pigmentary retinopathy (HP:0007737)1.71907134
91Oculomotor apraxia (HP:0000657)1.71400611
92Drooling (HP:0002307)1.71323050
93Severe visual impairment (HP:0001141)1.71183180
94Gastroesophageal reflux (HP:0002020)1.70884452
95Short foot (HP:0001773)1.70360874
96T lymphocytopenia (HP:0005403)1.70008881
97Abnormality of incisor morphology (HP:0011063)1.68865157
98Intellectual disability, progressive (HP:0006887)1.68797880
99Progressive cerebellar ataxia (HP:0002073)1.67849703
100Atonic seizures (HP:0010819)1.67716169

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.62068126
2TAOK33.26161793
3PINK13.05669942
4MAP4K12.89002379
5SIK22.39681796
6TXK2.21860413
7MARK12.21551208
8MAP3K42.05816361
9MAPK131.86768744
10MARK31.85243601
11WNK31.78830395
12FES1.77367438
13CASK1.76721905
14CDK61.62918418
15TNK21.61181747
16NTRK21.59911083
17ADRBK21.50810393
18IRAK41.50252007
19WNK41.43508491
20IRAK11.42254706
21SIK31.37606123
22GRK11.34128107
23ITK1.32812681
24CDK41.31622567
25PAK31.31334768
26BCR1.31191306
27WNK11.30001500
28ZAK1.27273014
29BRD41.25988539
30NTRK31.25888318
31SYK1.24046614
32YES11.19491706
33MAP2K71.18918821
34BLK1.15300981
35IKBKE1.10771494
36MUSK1.09693681
37FRK1.08384208
38EIF2AK11.06701984
39TYRO31.04691633
40TYK21.00121133
41CDK30.99403720
42PNCK0.98078396
43NEK60.97787002
44JAK30.97394905
45FGFR30.96200423
46PRKD20.95973268
47BTK0.91858306
48GRK60.91088347
49RPS6KA40.90213011
50NEK90.88826581
51IKBKB0.87003255
52FGR0.85486175
53BMPR1B0.85045175
54RIPK40.84812864
55SGK20.82990274
56DYRK30.80395621
57JAK10.78585757
58MAP3K140.78551333
59HCK0.78415815
60KSR10.77687045
61PRKCQ0.76294627
62DYRK20.73748023
63NLK0.71499573
64MAP2K20.70932136
65CSNK1G10.69853852
66LYN0.69643373
67TEC0.67949074
68PIM10.67771735
69CHUK0.65305467
70FGFR40.64172467
71MAP3K70.63180880
72PASK0.63013277
73JAK20.61593892
74LCK0.61547022
75PLK20.61368017
76PRKD30.60436756
77DYRK1A0.60325892
78PRKCH0.59594352
79DYRK1B0.59269042
80CAMKK20.56002459
81CSNK1G20.53274060
82SGK4940.51222715
83SGK2230.51222715
84CSF1R0.50982834
85CSNK1G30.50014343
86CSNK1A1L0.49263192
87FGFR20.47358610
88CAMK40.46704860
89PRPF4B0.45276998
90ATR0.44456328
91EIF2AK30.43669144
92MAPK90.43585412
93STK110.42877020
94PDK20.41881610
95PRKCZ0.40563084
96INSRR0.39695709
97IRAK20.37760246
98RPS6KA50.37303750
99ERBB20.36972226
100ABL10.36572290

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.72394935
2Basal transcription factors_Homo sapiens_hsa030222.91133053
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.51505946
4Phototransduction_Homo sapiens_hsa047442.48890712
5T cell receptor signaling pathway_Homo sapiens_hsa046602.21302890
6Dorso-ventral axis formation_Homo sapiens_hsa043202.14651683
7Nicotine addiction_Homo sapiens_hsa050332.05072995
8B cell receptor signaling pathway_Homo sapiens_hsa046621.73440834
9Cocaine addiction_Homo sapiens_hsa050301.71201530
10Morphine addiction_Homo sapiens_hsa050321.70841145
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.68019239
12Olfactory transduction_Homo sapiens_hsa047401.61638797
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.60910999
14RNA degradation_Homo sapiens_hsa030181.58872737
15Amphetamine addiction_Homo sapiens_hsa050311.55796811
16Measles_Homo sapiens_hsa051621.52482633
17Regulation of autophagy_Homo sapiens_hsa041401.46182389
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.39894132
19Linoleic acid metabolism_Homo sapiens_hsa005911.39297739
20RNA polymerase_Homo sapiens_hsa030201.38615151
21Lysine degradation_Homo sapiens_hsa003101.37321267
22Steroid biosynthesis_Homo sapiens_hsa001001.36808916
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.36036607
24Ether lipid metabolism_Homo sapiens_hsa005651.32364746
25Taste transduction_Homo sapiens_hsa047421.28518306
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.27381340
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26641547
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.26221217
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.25553995
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.24483768
31Herpes simplex infection_Homo sapiens_hsa051681.21714946
32Acute myeloid leukemia_Homo sapiens_hsa052211.18344683
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17074366
34Autoimmune thyroid disease_Homo sapiens_hsa053201.17032984
35Chemokine signaling pathway_Homo sapiens_hsa040621.13903174
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09903344
37Circadian rhythm_Homo sapiens_hsa047101.07935382
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03705402
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03411640
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02859080
41Allograft rejection_Homo sapiens_hsa053301.01460029
42Tryptophan metabolism_Homo sapiens_hsa003801.01248464
43Butanoate metabolism_Homo sapiens_hsa006501.00832528
44GABAergic synapse_Homo sapiens_hsa047271.00773976
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.00495307
46Protein export_Homo sapiens_hsa030601.00436906
47Osteoclast differentiation_Homo sapiens_hsa043800.98913320
48Graft-versus-host disease_Homo sapiens_hsa053320.91613211
49Prolactin signaling pathway_Homo sapiens_hsa049170.89255273
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89046555
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.88258289
52TNF signaling pathway_Homo sapiens_hsa046680.85209740
53Caffeine metabolism_Homo sapiens_hsa002320.84909620
54ABC transporters_Homo sapiens_hsa020100.84408453
55Epstein-Barr virus infection_Homo sapiens_hsa051690.82929646
56FoxO signaling pathway_Homo sapiens_hsa040680.82691652
57Dopaminergic synapse_Homo sapiens_hsa047280.81449060
58mRNA surveillance pathway_Homo sapiens_hsa030150.80292651
59Hepatitis B_Homo sapiens_hsa051610.79750605
60Circadian entrainment_Homo sapiens_hsa047130.75389475
61Influenza A_Homo sapiens_hsa051640.72546361
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72089170
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69765296
64Type II diabetes mellitus_Homo sapiens_hsa049300.68310070
65Choline metabolism in cancer_Homo sapiens_hsa052310.67357138
66Spliceosome_Homo sapiens_hsa030400.66967758
67Glutamatergic synapse_Homo sapiens_hsa047240.66869466
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65064063
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64114216
70Cholinergic synapse_Homo sapiens_hsa047250.64113246
71Glycerolipid metabolism_Homo sapiens_hsa005610.62840392
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.61990174
73Apoptosis_Homo sapiens_hsa042100.58286793
74MAPK signaling pathway_Homo sapiens_hsa040100.57716419
75Hedgehog signaling pathway_Homo sapiens_hsa043400.56547215
76Salivary secretion_Homo sapiens_hsa049700.54955668
77Inositol phosphate metabolism_Homo sapiens_hsa005620.54638408
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54389538
79Type I diabetes mellitus_Homo sapiens_hsa049400.54185901
80Tuberculosis_Homo sapiens_hsa051520.53348218
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51287804
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50501628
83Ras signaling pathway_Homo sapiens_hsa040140.49903601
84Histidine metabolism_Homo sapiens_hsa003400.49479883
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48906998
86Phenylalanine metabolism_Homo sapiens_hsa003600.48424803
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47324887
88Estrogen signaling pathway_Homo sapiens_hsa049150.47119434
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46656973
90Leishmaniasis_Homo sapiens_hsa051400.45649995
91Selenocompound metabolism_Homo sapiens_hsa004500.43931508
92Asthma_Homo sapiens_hsa053100.43631105
93Renal cell carcinoma_Homo sapiens_hsa052110.43206946
94Non-small cell lung cancer_Homo sapiens_hsa052230.43127211
95Oxytocin signaling pathway_Homo sapiens_hsa049210.43014949
96Fanconi anemia pathway_Homo sapiens_hsa034600.41678381
97Hematopoietic cell lineage_Homo sapiens_hsa046400.41299767
98Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.41229982
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40219497
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37929880

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